Federico Gueli 🏳️ @siamosolocani Twitter profile | Pikagi

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Federico Gueli 🏳️

@siamosolocani

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Brother of dogs struggling for peace while seeking variants RT =not endorsment! Background pic by Maya Levin

Joined March 2022

Don't wanna be here? Send us removal request.

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@siamosolocani

Federico Gueli 🏳️

1 year

Volevo ringraziare @LuciaScopelliti per l'articolo su @Adnkronos perche' sono riuscito a raccontare nella mia lingua la storia di un gruppo di persone di valore che in maniera disinteressata e collaborativa hanno cercato di dare una mano,in fondo,a tutti

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Covid. Da Cerberus a Kraken, quei cittadini diventati cacciatori di varianti

Setacciano sequenze come gli scienziati e gomito a gomito con alcuni di loro. L'italiano Gueli: 'I nickname dati alle nuove versioni di Sars-CoV-2? E' per informare le persone in modo semplice, non...

www.adnkronos.com

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@siamosolocani

Federico Gueli 🏳️

2 years

While BA.5.2 lost the world but took China and while XBB.1.5 is fastly arising there are many countries with unique variants dominating/leading there: 1 Philippines BA.2.3.20 2 New Zealand CH.1.1 3 Russia CL.1 4 Australia XBF BR.2.1 5 India XBB 6 South Korea BN.1.3 7 Japan BF.5

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Federico Gueli 🏳️

1 year

I have to say that with or without BA.2.86 we have already FLip lineages coming and i dont see sufficient focus on them beyond the great work of @yunlong_cao Look at their doubling time. Again look at their doubling time I would not to see then excuses like no one warned us.

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Federico Gueli 🏳️

2 years

CK.2.1.1 is coming from nowhere, fast. it is a BA.5.2.24 (Orf1b:1050N+S:444N) +E:V62F + Orf1a:V710I + Orf1a:G3578D+ S:460K + S:255F another one in the game @SolidEvidence @EricTopol @K_G_Andersen @CorneliusRoemer @Rajeev_The_King @PeacockFlu @firefoxx66 @TRyanGregory >Myth

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Federico Gueli 🏳️

11 months

JN.1 full gas : Now its advantage over the baseline is 100% so it is a BA.5 event more than a XBB.1.5 in terms of growth advantage. A new era is likely beginning. The first competitor is XTC.1 with 70% over bsl then BA.2.86 sublineages & fastest Flip JG.3/JD.1.1.1 ~50% over bsl

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Federico Gueli 🏳️

2 years

Appello ai #nonni : fino alla circolazione di Delta siete stati morti che camminano (mortalita' over 65 da 1/100 a 1/5 ). Migliaia di bambini,adolescenti e giovani hanno sofferto molto le restrizioni che vi han salvato la vita. Il modello #Meloni era Bolsonaro Putin Trump1/

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Federico Gueli 🏳️

1 year

The fastest now are EG.5.1 and FL.1.5.1 but be aware that a new generation of variant is coming , the first we will see will be HK.3 a Eris descendant carrying the FLip mutations L455F/F456L . Newbies to watch: HV.1 (452R-456L) HW.1.1 (XBC.1.6.3 +S:460H) GW.5 (455-456-478-554)

@EmMicucci

Emanuela Micucci

1 year

#Covid Tra le nuove #varianti circolanti occhi puntati anche su FL.1.5.1 Già sequenziata in tantissimi viaggiatori da Europa occidentale, Italia compresa, negli aeroporti americani. Per il cacciatore di varianti italiano #Gueli è più veloce di EG.5.1 @siamosolocani

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Federico Gueli 🏳️

8 months

@EylonALevy @WHO As occupying power in Gaza it is your duty to provide it.

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@siamosolocani

Federico Gueli 🏳️

1 year

Super short variant update: Hk.3 is coming and will give birth to a wave , being faster than it JG.3 and BA.2.86 will come just after it ( in a Fornax+Eris like scenario) or with it if JN.1 will confirm its advantage FL.15.1.1 (FLip+475V) appears to be very fast but small so >?

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@siamosolocani

Federico Gueli 🏳️

2 years

What XBC.1.6? It is a Deltacron (recombinant with the Spike and most of orf1ab from Omicron the rest from Delta) Why are we talking of it? It managed to reach 30% of samples in second half of March in South Australia. South Australia is experimenting a sudden wave. part 1

@Mike_Honey_

Mike Honey

2 years

Here's the latest variant picture for South Australia. Growth of the new "Deltacron" XBC.1.6 variant has continued, reaching 30%. It seems likely this is driving the surge in cases and the reported impacts on hospitals and the ambulance service.

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Federico Gueli 🏳️

2 years

Back from Mars. Now BA.2.75 advantage is "just" 206% @mildanalyst @RajlabN @r_karyakarte @PeacockFlu @CorneliusRoemer cc prof @TWenseleers probably now you could rerun your analysis there are sufficient BA.5 samples from India to an affordable one.

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Federico Gueli 🏳️

1 year

Verdict on #Okinawa outbreak is out. It wasnt EG.5.1 driving cases there. But Arcturus as in India earlier in March. Notable XBB.1.16 got a S:E748Q interesting mutation in many samples there. XBB.1.16 is around 40-50% of the 200 samples collected in Okinawa in July. EG.5.1 at 2%

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Federico Gueli 🏳️

2 years

Little update on variants circulating in China. First a big thanks to all scientists in ML China and in other countries doing the sequencing lab. Second thx to other variant hunters as Silcn, who working alone without any support found the main two variants circulating there 1/

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@siamosolocani

Federico Gueli 🏳️

2 years

4/ Non date un voto a @matteosalvinimi e @GiorgiaMeloni , fosse stato per le loro idee chiaramente dichiarate alle urne potevate non arrivarci. Questo almeno lo dovete ai giovani che vi hanno protetto: Non rovinate il loro futuro votando a destra.

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Federico Gueli 🏳️

1 year

Exclusively a fear of mine: The coming double punch right left from Flip and BA.2.86 over an already high baseline I hope to be just too alarmist .

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@siamosolocani

Federico Gueli 🏳️

2 years

Lil variant update: The fight now is BA.2.75 vs BA.5.2+Orf1b:1050N BA.5.2.1 +S:1020S BA.5.2.1+ N:33F BA.4 +S:346 mutated BA.5 +S:346 mutated BA.2.38.2 BA.2.38+S:478R/1264L BA.2.75 'd win easily against BA.5 but not vs the ones mentioned above.

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Federico Gueli 🏳️

10 months

New update on Growth advantages by @BenjMurrell . It explains what we are seeing worldwide confirming the early models by @JPWeiland and @Asinickle1 and the chart #Collection42 maintained by @wolfeagle1989 using @ChaoranChen_ 's @GenSpectrum tool!

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@siamosolocani

Federico Gueli 🏳️

10 months

Ht @nzm8qs Singapore cases break 2023 high recorded during XBB.1+486P wave. Cases near doubled in comparison to that time. Hospitalizations following the same path

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Federico Gueli 🏳️

10 months

JN.1 is an outlier without it we should have been watching a fight between evovlved flips and Pirolas. No fight here, JN.1 has won. thx @wolfeagle1989 for updating #collection42 via @ChaoranChen_ precious tool

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Federico Gueli 🏳️

2 years

XBB.1.16 is showing big jump in Prevalence at least in four countries: MH, India Gujarat, India Brunei India (travellers to Singapore). It could be the next thing, i think it will.

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@siamosolocani

Federico Gueli 🏳️

2 years

Briefly. variant update: BA.2.75 is acquiring new spike mutations and with them it will likely become dominant. Unclear if BH.1&BJ.1 could compete or not. The baseline (i mean for that most transmissible among the most sequenced lineages) is still BA.5.2 + Orf1b:1050N. 1/

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Federico Gueli 🏳️

2 years

Evolution goes fast in India. Here a new proposal whilr we have already two designated (BA.2.75 and BH.1 ) and one more proposed all with multiple spike mutations (N=8,>8)

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BA.2.10.1 sublineage with S:V83A, 144del, H146Q, Q183E, V213E, G339H, R346T, L368I, V445P, G446S,...

Proposal for a sublineage of BA.2.10 Earliest sequence: 2022-07-02 Countries detected: India (9 seq, all from West Bengal) Mutations in addition to BA.2.10: S:V83A, H146Q, Q183E, V213E, G339H, R346...

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@siamosolocani

Federico Gueli 🏳️

1 year

I want to share the best example of variant tracking i have ever seen from the start of the pandemic : it is about EG.5.1 + #FLip lineages: an anonymous github user @NkRMnZr tracked everything popping up with that combo (455F/456L) for 50 days. He spotted around 50 sublineages

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@siamosolocani

Federico Gueli 🏳️

2 months

This is not correct. Xdv.1 is not a deltacron and has the jn.1 spike with 456L plus just some mutations inherited from xbb outside the spike as orf1b:G662S, Orf9b:I5T, Orf1a:K47R

@COVID19_disease

SARS‑CoV‑2 (COVID-19)

@COVID19_disease

2 months

⚠️ BREAKING 🇨🇳 China Faces New COVID-19 Surge with Recombinant Variant XDV.1 Recent reports from China reveal a concerning resurgence of COVID-19 driven by a new recombinant variant, XDV.1, which combines Delta and Omicron strains.

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Federico Gueli 🏳️

4 months

Variant update: KP.3.1.1 (spotted first by @Asinickle1 ) seems to have a pace not matched by anything else, it is still mostly a Spanish lineage with a prevalence there in the second half of May around 10%, but Spain is also experiencing a surge in cases.

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@siamosolocani

Federico Gueli 🏳️

2 years

Now it is official we have a new dominant variant it is BA.5.2* that last weeks was over 50% of global samples . It reaches the hall of shame with B.1*, B.1.1*, ( then B.1.177 missed that goal) B.1.1.7*, B.1.617.2*, BA.1*, BA.2* and BA.5*.

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Federico Gueli 🏳️

1 year

Very important information on BA.2.86 from Austria. No under the radar spread there. Cc @PeacockFlu @lon @JosetteSchoenma @TRyanGregory Please spread to groups i m blocked again.

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Federico Gueli 🏳️

7 months

Variant update: we are likely entering quite fastly in a new JN.1 era that will likely be dominated by lineages carrying up to 5 spike mutations (as of today) from JN.1 , mainly carrying at least a combo of the highly convergent trio of Spike mutations 346T 456L 572I ,

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@siamosolocani

Federico Gueli 🏳️

1 year

Variant update: JN.1 ahead of everything. Then JG.3, GW.5.1.1 Hk.3 sublineages, some Hk.3-like and HV.1.1 then JD.1.1* , Flip recombinants (XCR,XCT,XCM,XCY), Flip475V, HV.1 and BA.2.86. outsiders FL.1.5.2/XDA/HN.5/GY.8+Flip Mayority of the rest will go further back soon.

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Federico Gueli 🏳️

1 year

EG.5.1.7 ( S:K278N ) is coming up very fast. Excellent early spot by @CorneliusRoemer (as HV.1 ) It could be someway enhancing ACE.2 binding according to @jbloom_lab new mutational scanning:

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Federico Gueli 🏳️

2 years

Brand new donuts of the variant night bakery: BU.1 and BW.1 (both ""BQ.1like"") BV.1 the fastest lineage on earth without escape mutations at 346/444/460 XBB Mix BJ.1/Centaurus BA.2.83 a zombie directly from the original BA.2 grave. BL.1.1 with D614S thx @CorneliusRoemer

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Federico Gueli 🏳️

1 year

Great work by @CorneliusRoemer in designating a lot of new lineages tonite. also new sublineages of XBB.1.16 (.2 and FU.s), more 478Rers and 456Lers

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Federico Gueli 🏳️

1 year

Lineages to watch: BA.2.86*, Flip HK.3 JG.3 Flip+452R DV.7.1 HV.1 (452+456) Recomb Flip: XCH XCL XCM Flip+478: JF.1 GW.5 GW.5.1.1 Mix mutations: GA.4.1, GS.4.1, JE.1 , FL.1.5.2, XBB.1.16.24 , XBB.1.16.15, GL.1* , GJ.1.2 With 484K: EG.6.1.1 FL.30 No 486P: FW.1.1 CK.1.1.1 JH*

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Federico Gueli 🏳️

3 months

Likely this week we have already a new dominant lineage worlwide it is KP.3* . It joins the club of dominant lineages B.1 B.1.1 Alpha Delta BA.1 BA.2 Ba.5 BA.5.2 BA.5.3, BA.5.3.1,BE.1*, XBB.1.5 , XBB.1.9* XBB.1.9.2*, EG.5.1, BA.2.86, BA.2.86.1 JN.1* JN.1.11* JN.1.11.1*

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Federico Gueli 🏳️

2 years

Thanks to indian scientists like @r_karyakarte today we had a big upload of XBB.1.16 sequences from India. ( Brunei labs too) My prevalence very roughly estimated from gisaid uploads talks about something going from 2% between jan10-feb10 to 35-40% between feb11 to mar10

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Federico Gueli 🏳️

1 year

Late night in Europe but variant community is not asleep! A lot of designation made by the awesome @CorneliusRoemer , he does alone half of the global work on variants! @redbull you should sponsor him for life! A lot of new things around got designated tonight: 3d >>>

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Federico Gueli 🏳️

2 years

Minutes after this tweet a big upload of samples from Shandong changed things! we have a new lineage circualting in China, i have already proposed it at teh beginning of January, now i've updated the original issue: It is ,again , a BA.5.2 sublineage!

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BA.5.2 + orf1b:1050N sublineage with Orf1a:T3284I,then orf1a:R207C, orf1a:S2488F and Orf1b:P1727L...

EDITED I will competely rewrite this issue after the mass upload of sequences from Shandong last night. Initially i proposed it separately in #1565 but then i realize thast this has the same root o...

@siamosolocani

Federico Gueli 🏳️

2 years

Big upload from China today: 648 sequences from many new provinces as Heilongjiang, Jilin, Jiangxi or from undersampled provinces as Anhui, Hunan, Tjanin, Sichuan No new lineage! 358> BA.5.2.48 245>BF.7.14 36>BA.5.2.49 7>BA.5.1.32 2>others cc @dfocosi

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Federico Gueli 🏳️

1 year

EG.5.1 is spreading around the globe and it will be protagonist in the next weeks. Worth mentioning It has been discovered independently by @CorneliusRoemer who designated it with just a dozen of samples and hours later by @AlexJohnsonLi3 , one of the new variant spotters

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@siamosolocani

Federico Gueli 🏳️

1 year

New sample from Michigan found by @agamedilab and @OliasDave . Bad news it is one only lineage not two. it has all the mutations Israelian sample had and also one from Danish ones. So this could mean no prolonged circulation somewhere.

@LongDesertTrain

Ryan Hisner

@LongDesertTrain

1 year

There's a ton of uncertainty about exactly what effect the ≥30 mutations in the new BA.2 lineage have, but @jbloom_lab , with his deep mutational scanning data, probably has a better idea than anyone about the likely effects of many of the mutations. 🧵 1/2

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@siamosolocani

Federico Gueli 🏳️

2 years

A kudos to @CorneliusRoemer for discovering and designating XBB.1.5 when it was just 3 sequences setting a new record for discovering dominant variant after the B.1.1.529 discovery by @PeacockFlu when it was 4. then BA.2.75 when it was 5 seqs by Silcn then BQ.1 when it was 6

@SystemsVirology

The Sato Lab (Kei Sato)

@SystemsVirology

2 years

@EricTopol @yunlong_cao @biorxivpreprint Not really from us, unfortunately. As you know XBB.1.5 is XBB+S:S486P. The COVID predictor, @yunlong_cao , shows the data in his fantastic paper and explains it in his thread below:

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@siamosolocani

Federico Gueli 🏳️

1 year

2 months ahead of things. it is not me. it is a community of person working for everyone.

@siamosolocani

Federico Gueli 🏳️

1 year

@wanderer_jasnah @alchemytoday And everyone please take a look at HK.3 (EG.5.1.1.3) it got the 455-456 combo and in my view it will fly.

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Federico Gueli 🏳️

2 years

Lost in Omicron Centauri? BA.2.75.1 :S:D574V Ba 2.75.2: S:346T S:486S BA.2.75.3: orf1b:V1706I BA.2.75.4:S:L452R BA.2.75.5: S:K356T BL.1 is BA.2.75.1.1 with S:346T

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Federico Gueli 🏳️

1 year

I am saying it another time: The fastest Flip are coming quickly and unluckily they are not alone but with Pirola too. Ok they very likely should not be more severe but big numbers bring big troubles. I overstress it for sure, but unsure it has been understood well Take a vaccine

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@siamosolocani

Federico Gueli 🏳️

8 months

Variant update: JN.1 evolution currently and mainly via 346X 456L and 572I , the underdog to watch from Brazil could be JN.1.23 (444r+453F) from Brazil designated today and spotted by @LongDesertTrain . Outside JN.1 , recombinants of BA.2.86 with its spike are doing quite well

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@siamosolocani

Federico Gueli 🏳️

2 years

For public and scientists getting lost in new Omicrons we have now released a very easy collection on @GenSpectrum (thx @ChaoranChen_ ) to track the fastest designated lineages. This is possible just thx to nextclade team and @CorneliusRoemer vs BA.5*

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Federico Gueli 🏳️

10 months

JN.1 leading strongly. JG.3.2 went down as its advantage was mostly by canadian clusters sequenced from long term care home. XDD climbing the chart likely to reach close JN.1, behing just a couple of HK.3 able to keep HALF the growth advantage of JN.1. BA.2.86ers are over flip.

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Federico Gueli 🏳️

11 months

Local media of my town @laprovinciadico covered well my path to the variant community, I am especially happy cause i was able to credit Pango, Usher, Nextclade, CovSpectrum and Gensplore, without them our whole work would be impossible! And same x @CorneliusRoemer & @PeacockFlu !

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Federico Gueli 🏳️

2 years

@TWenseleers I would like to thank people in the lab in India doing the sequencing. I know that is 1 AM there and still someone is preparing the files to upload to Gisaid. It is not a game of variants. It is hard work dome for we all. thx @r_karyakarte and colleagues.

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Federico Gueli 🏳️

1 year

Even if we know still little of BA.2.86 I think we as variant community had done everything we could to track timely things, uniquely thx to great tools as Usher, Pango, Nextclade, Covspectrum and Sequences uploaded to Gisaid by lab scientists.

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Federico Gueli 🏳️

11 months

We have a clear break now among variants with JN.1 with a solid advantage over the first competitor JG.3 that has a moderate advantage over HK.3 ( the next leader lineage) [don't credit the lineages within the two lineages they are biased by clusters]

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Federico Gueli 🏳️

1 year

Flip lineages now close to 80% in Singapore. It is just one month ahead of the rest of the world.

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Federico Gueli 🏳️

2 years

Huge work by @CorneliusRoemer in designating new sublineages last night. And new data arrived from Gisaid to Covspectrum so the new updated situation last 50days is the following: we are in a recombinant era. New entry XAY.1.1.1 and as predicted XBL rising.

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Federico Gueli 🏳️

2 years

Now it is quite everything designated in India : BJ.1 BH.1 BA.2.10.4 BA.2.76.1 BA.2.75. These are fruits of evolution vs immunity. We now will see 'em outside india: Prof. @TWenseleers , maybe, if needed, in the next weeks will tell us about their growth on global scenario.

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@siamosolocani

Federico Gueli 🏳️

6 months

@haaretzcom It is a shame and a war crime, not frustrating. I think israel officers won't be able to travel outside Israel for the rest of their lives: jurisdiction is universal

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Federico Gueli 🏳️

2 years

Another XBB.1*486P thing coming from Africa ,it has high prevalence in Cote d' Ivoire and it has been sampled in or from multiple african countries : it seems already going fast in France going from 0,1 to >1% (cc @SimonLoriereLab ) spotted by Hynn Spylor

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Potential XBB.1 sublineage with ORF1ab:L469F (C1670T), S:D215H (G22205C) and S:F486P(T23018C)...

Defining mutations: XBB.1>ORF8: G8* (G27915T)> ORF1ab: L469F (C1670T)> S:D215H (G22205C)> S:F486P (T23018C) GISAID query: C1670T, G22205C, T23018C Earliest seq: 2023-01-05 (Belgium, EPI...

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Federico Gueli 🏳️

2 years

Here my last update on #collection24 fro a while then i will take a break. Landscape is now dominated by recombinants : XBB.1.5,XBB.1.9.1,XBB.1.9.2, XBL as leaders will dominate the world outcompeting diversity outside them: just CM.8.1.1 some CH.1.1 and some BQ.1* wont die

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Federico Gueli 🏳️

6 months

Great work by @BenjMurrell out now with the new growth advantages of all the circulating variants: Perfectly matching the early warning (and tracking) of variant community especially @xz_keg @CorneliusRoemer @JosetteSchoenma @AlexJohnsonLi3 ..cont

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Federico Gueli 🏳️

2 years

First lineage designated after it was forced to emerge by Molnupiravir use BF.5.3 thanks @LongDesertTrain for spotting and tracking it

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BF.5 Sublineage with >20 private mutations, possible molnupiravir origin, Japan (22 seq, Jan 27) ·...

Description Sub-lineage of: BF.5 Earliest sequence: 2022-10-24 — EPI_ISL_15673587 Most recent sequence: 2022-12-23 — EPI_ISL_16374103 Countries circulating: Japan (All), 14 from Mie Prefecture, 1 f...

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Federico Gueli 🏳️

1 year

EG.5.1 likely this week or the next will be dominant globally (>50% of seqs in one week) it will join B.1 B.1.1 Alpha Delta BA.1 BA.2 BA.5 BA.5.2 BQ.1 (Cerberus) XBB (Gryphon) XBB.1 (Hyppogryphon) XBB.1.5 (Kraken) and XBB.1.9* (Hyperion,who is leading since Sept 23)

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Federico Gueli 🏳️

1 year

While suisse wastewaters report the presence of BA.2.86 in multiple locations , genomes uploaded to Gisaid in September tell us that there Flip lineages already reached 30% of sequences-

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Federico Gueli 🏳️

1 year

Flip doing Flip

@BiobotAnalytics

Biobot Analytics

@BiobotAnalytics

1 year

A benefit of sequencing SARS-CoV-2 in #wastewater is observing how the virus changes. Our data shows that a combo of new mutations, called FLip because they involve two L to F amino acid mutations, are increasing in the US. #WBE #populationhealth

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Federico Gueli 🏳️

9 months

JN.1 Saltation spotted by the @SuperTY1995 (thank you!) With four RBD mutations: 456V, 468N, 477D, 489F. Just a singlet.

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JN.1.1 (BA.2.86.1.1.1) 16-nuc saltation seq with S:G261A, S:D264A rev, S:F456V, S:I468N, S:S477N-...

Defining mutations: JN.1.1>C11747T>C9142T>saltation branch nuc and AA mutations: ORF1a: C4069T, C4999T, A11951T (ORF1a:N3896Y), G11954T (ORF1a:D3897Y) ORF1b: C19951A (ORF1b:P2162T) S: G223...

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Federico Gueli 🏳️

9 months

We may have found a main non BA.2.86 follower for JN.1 spike family (JN.1/XDD/XDK). It is GE.1.2.1 from Acrux/XBB.2.3 family. After him some HV.1/JG.3/HK.3.2/HK.24 descendants could make it through this wave. Underdogs KH.1 (Acrux) , HN.4.1.1 (Fornax) , FY.5.1.1(Bellatrix), XDA

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Federico Gueli 🏳️

10 months

JN.1 was tracked since it was one sequence only, spotted by @OliasDave . But once again i have to thank @CorneliusRoemer that is man then drove us right on the shoulders of the virus. Starting tracking a variant before a designation when it is 1-20sh sequences is the key .

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Federico Gueli 🏳️

2 years

We have FK.1 . One to watch. ORF1a:L3829F, S:D215G, S:Q613H, M:S212G on CH.1.1.17 backbone

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Federico Gueli 🏳️

1 year

@JenniferNuzzo "People on internet " are the same ones which seek variants and find them , then flag them to health authority nicknaming months before they are moved to VUM or VOI. Pls Stop this duality with people doing the job on the field. Nicknames are just to make things communicable

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Federico Gueli 🏳️

1 year

XCH,XCL,XCM all FLip recombinants coming up fastly to watch closely. I am not sure if around it is completely understood that FLips are coming at double speed than the actual dominant lineages. The only one there with them is BA.2.86 and a couple of XBB.1.16 sublineages

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Federico Gueli 🏳️

2 years

BQ.1.1 now has been overtook in the lead by BA.2.3.20 ( @LongDesertTrain spotted it very early from really 3-4 seqs), XBB is roaring behind these two. @firefoxx66 @EricTopol @SolidEvidence @yunlong_cao @macroliter @Mike_Honey_ @T_Brautigan @r_karyakarte

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covSPECTRUM is an interactive platform aiming to help scientists investigate and identify variants of SARS-CoV-2.

cov-spectrum.org

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Federico Gueli 🏳️

2 years

After B.1 , B.1.1 , Alpha, Delta, BA.1, BA.2, Ba.5, BA.5.2 we have now an ninth lineage that managed to get dominance globally (=over 50% of global samples in a week) . It is BQ.1* aka BA.5.3.1.1.1.1.1* With the chinese wave and the sudden raise of XBB.1.5 likely it is no more!

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Federico Gueli 🏳️

2 years

3/ In particolare la moria avvenuta in altri paesi x Delta qua e' stata ben attuttita da una campagna vaccinale aggressiva e da misure estreme come il #greenpass .

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Federico Gueli 🏳️

2 years

Mentre tutti parlano di possibili varianti dalla Cina, ne abbiamo una tutta nostra o quasi in Umbria sequenziata dai nostri scienziati sul campo Un recombinante tra BQ.1.1 e Ba.2.75 un Cerbertaurus si potrebbe dire. Scoperta da @nzm8qs

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Federico Gueli 🏳️

1 year

What i am seeing thx to the huge tracking workload by NKrMnZr with FLip and EG.5.1 family is unprecedented. We count more 60 independent emergence of this combo on EG.5.1 backbone. Lets say 80% of them are artifact, to say: still something unprecedented. And mainly from China

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Federico Gueli 🏳️

1 year

@mvankerkhove Why not? the system is working now. You named the stadium , we are naming the players, everyone understands what is going on. And if Maradona will be back you may will rename the stadium and we will throw our nicknames

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Federico Gueli 🏳️

2 years

Great catch and super well written proposal by @LongDesertTrain but good things end here. It is another heavily mutated 2nd generation BA.2 variant ( the 2nd found just today). This one has S:478 reverted to T (as WT)

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BA.2 Sublineage with 13 mostly convergent spike mutations (India, 7 seq, 3 regions on Sept 15) ·...

Description Sub-lineage of: BA.2 Earliest sequence: 2022-7-23, India, Rajasthan (Jodhpur) — EPI_ISL_14775115 Most recent sequence: 2022-8-5, India, Maharashtra (Pune) — EPI_ISL_14568402 Countries c...

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Federico Gueli 🏳️

2 years

The game is restricted to 5 or 6 sublineages. XBB.1.9.1, XBB.1.9.2 and its son EG.1 , XBL and maybe EK.1 son of XBB.1.5 (likely there are other sublineage of XBB.1.5 which can compete) Behind them BQ.1.1+mutations around 248 and last fast CH.1.1ers but too far to count.

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Federico Gueli 🏳️

8 months

Now JN.1.23 in just three days landed to.Australia found by @LongDesertTrain , Canada found by @Asinickle1 California(2) by @RajlabN . It is clearly expanding week by week lets see if it has an advantage versus the already evolved to 346X/456X/572I JN.1 variants circulating

@siamosolocani

Federico Gueli 🏳️

8 months

Variant update: JN.1 evolution currently and mainly via 346X 456L and 572I , the underdog to watch from Brazil could be JN.1.23 (444r+453F) from Brazil designated today and spotted by @LongDesertTrain . Outside JN.1 , recombinants of BA.2.86 with its spike are doing quite well

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Federico Gueli 🏳️

1 year

They are all there. As predicted in the tweet below. Look at XBB.1.5.42 (445S) or EG.5 (F456L) or XBB.1.31 (453F+478R) how they are coming fast from the bottom to the top. But the fastest as @LongDesertTrain said multiple times could be really XBB.2.3.2

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@siamosolocani

Federico Gueli 🏳️

1 year

Beyond XBB.1.16 and sublineages two eyes on : XBB.2.3 +478X (R,N,Q) XBB.2.3.2 EG.5 (XBB.1.9.2+456L) XBB.1.31 XBB.1.5.42+445S XBB.1.33

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Federico Gueli 🏳️

2 years

What is happening with variants? brief expl. 1-BA.5.2* is no longer the dominant lineage 2-Orf1b:1050N failed to rise to dominance down under 20% 3 S:346mutated is around 30% of samples actually 4 S:460K is around 10% rising but still far behind 346T 5 S:444 is around 6,5%

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Federico Gueli 🏳️

1 year

Everyone when attacking scientists should think before to scientists as @theosanderson @PeacockFlu Chris Ruis doing their job without fear retaliation from a giant company as @Merck And let me say the first and without any institution backing him was @LongDesertTrain

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Federico Gueli 🏳️

2 years

E questa non e' Delta,di conseguenza senza un ricorso ad ossigeno massivo. Fossi un minimizzatore o un deniers mi sentirei un pochino male per le sciocchezze dette.

@whyyoutouzhele

李老师不是你老师

@whyyoutouzhele

2 years

网友投稿 12月25日的北京朝阳医院

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Federico Gueli 🏳️

2 years

2/ dove gli over 65 sono morti come mosche in nome del potere personale di questo o quel #Presidente e dei gruppi di interesse che li supportano.

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Federico Gueli 🏳️

2 years

Variant swarm (or soup) is in China too. @EricTopol @yunlong_cao Mass upload from Shangai.

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Federico Gueli 🏳️

10 months

While JN.1 is having an impact it is right to remember that it was spotted first from one sequence onl7 by @OliasDave an english computer/Data scientist that is part of the variant community and who provided several tools to spotters. Another unchanted human being serving humans!

@JPWeiland

JWeiland

10 months

December 4th Update: As predicted, a huge jump in numbers this week. 40% ⬆️ over last week. Pirola ⬆️⬆️. 🔸850,000 new infections/day 🔸1 in every 390 new people were infected today 🔸1 in every 39 people currently infected

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Federico Gueli 🏳️

1 year

S:403K is completely dominant in South Africa in August: 44/68 samples carry that mutation in the RBD . And it is not from one lineage only but from 4! They are Ba.2.86,XBB.1.41 , XBB.1.5.53/JB and XBB.1.28 . XBB.1.41 has the lead there with over 20% followed by JB* and BA.2.86

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Federico Gueli 🏳️

10 months

Last week we had a new globally dominant lineage: it is BA.2.86* aka Pirola, It comes after B.1, B.1.1, Alpha, Delta, BA.1, BA.2, BA.5 , BA.5.2, BQ.1*, XBB*, XBB.1*, XBB.1.5*, XBB.1.9*, XBB.1.9.2*, EG.5.1*. Likely this week or the next one it will be reached by JN.1.

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Federico Gueli 🏳️

2 years

Probably the first challenge that new italian premier @GiorgiaMeloni will front it will be a wave driven by BQ.1* a new 2nd generation BA.5 based variant that seems very very fast and able to start a wave globally. Irony, it has been discovered by an italian, me, as she likes.

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Federico Gueli 🏳️

1 year

With this paper, if further confirmed by other scientists, the expression "scariants" should be buried for ever. BA.5.48 BA.5.49 BF.7.14 have been estimated to spread with Reff over 3.0 much superior to the original Wuhan strain

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Swift and extensive Omicron outbreak in China after sudden exit from ‘zero-COVID’ policy

Nature Communications - China ended its ‘zero-COVID’ policy in late 2022, but the public health impacts of the rapid removal of restrictions are not known. Here, the authors use...

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Federico Gueli 🏳️

2 years

Everyone should praise @CorneliusRoemer work: 1-Being behind nextclade developed the fastest tool to scan sequences, 2-helping to enhance @GenSpectrum with thousands of proposals and using it to the max to describe epi situations as below. 3-doing designations on @PangoNetwork

@CorneliusRoemer

Cornelius Roemer

@CorneliusRoemer

2 years

Most immune escape, rarest at this point: Mid-level escape but more common (left screenshot, for US): Least escape but most common (right screenshot, for US): All enabled by the amazing @GenSpectrum

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Federico Gueli 🏳️

2 years

This is UK #Collection24 a clear picture of real speed of variants. After 3-4 months of magma with a lot of lineages competing now the situation seems clearer: First tier :XBB.1.5 jump then: XBF jump third CH.1.1 jump few fastest variant soup BA.2.75s +BQs + CM.8.1 BE.9

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Federico Gueli 🏳️

2 years

8 Singapore XBB.1* 9 Hong Kong CH.1.1 this to say that nothing is certain, be dubious always never stop searching.

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Federico Gueli 🏳️

5 months

This is crazy. Please retweet showing support to scientist who are working for all of us before it will be late.

@SolidEvidence

Marc Johnson

5 months

We developed an assay for testing for H5N1 from wastewater over a year ago. (I wasn't expecting it in milk, but I figured it was going to poke up somewhere.) However, I was just on a call with the CDC and they are advising us NOT to use it. I need a drink.

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Federico Gueli 🏳️

2 years

Hard to forecast what will be the next future of the pandemic in terms of variants. two mutations S:F486P and maybe S:K356T will consolidate in the next months Fastest in my chart CH.1.1 XBF XBB BQ.1.1 and BN.1 sons. And a big eye on deltacrons XAYs/XBCs

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Federico Gueli 🏳️

2 years

Collection24 now automatized by the great @wolfeagle1989 : XBB.1.16 seems coming from mars we will see if true and why, as i suggested from the start XBB.1.9.2/EG.1 are slighty faster than XBB.1.9.1 while we see two new BQ.1.1 knocking on the leading pack back: ES.1 and Bq.1.1.71

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Federico Gueli 🏳️

9 months

This tweet went in the ongoing history of this pandemic

@LongDesertTrain

Ryan Hisner

@LongDesertTrain

1 year

Two more sequences of this 2nd-generation BA.2 lineage just showed up in Denmark. This is the real deal. There are slight differences between the three sequences, but they are nearly identical. Below is my preliminary summary of the mutations it has on top of BA.2. 1/2

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Federico Gueli 🏳️

2 years

Now we know what came back to Wuhan after 3 years of evolution. It has been BA.5.2.48, mainly, to drive the wave there. big upload from hubei tonight over 500 sequences @dfocosi

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Federico Gueli 🏳️

2 years

King of the Amazons just designated BE.9. It is a fast fast fast BQ.1 like ( but UNRELATED) emerging and spreading in Amazonas: thx to "Rede Genômica Fiocruz" @GrafTiago & AL Check how fast it is: selecting for Brazil last 2m

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covSPECTRUM is an interactive platform aiming to help scientists investigate and identify variants of SARS-CoV-2.

cov-spectrum.org

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Federico Gueli 🏳️

1 year

S:R403K "Ricky" could be the next mutation ? Early signs of that could be : complete dominance in South Africa, near dead lineage coming back carrying it, Fast lineages accelerating. Stay tuned

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Federico Gueli 🏳️

2 years

@yunlong_cao @JPWeiland @LongDesertTrain @EricTopol Just to add a thing: XBB.1.5 was discovered when it was just 3 sequences by @CorneliusRoemer

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Federico Gueli 🏳️

2 years

Another big XBB.1.16 upload from Gujarat today. and 3 more samples from Usa 2 from England 1 each from Canada and Austria. @MoritzGerstung @TWenseleers @EllingUlrich @SolidEvidence @PeacockFlu @trvrb @yunlong_cao

@siamosolocani

Federico Gueli 🏳️

2 years

Thanks to indian scientists like @r_karyakarte today we had a big upload of XBB.1.16 sequences from India. ( Brunei labs too) My prevalence very roughly estimated from gisaid uploads talks about something going from 2% between jan10-feb10 to 35-40% between feb11 to mar10

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Federico Gueli 🏳️

10 months

Looking at samples collected in the last two weeks from travellers arriving to american airports JN.1 is already over 20%, While looking at Gisaid sequences it is approaching to 20% in the same period. there is no sample older than 23 November: now it is likely is much higher

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