Raj Rajnarayanan @RajlabN Twitter profile

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Raj Rajnarayanan

4 hours

#COVID19 #VariantDashboard - #USA |10/03/24 #SARSCoV2 #Lineages #30DAYTRENDS KP.3.1.1 (34.6%) KP.2.3 (9.2%) XEC (3.7%)🆙 LB.1.7 (3.5%) KP.1.1.3 (2.4%) KP.3.3 (2.3%) LB.1 (2.2%) MC.13 (2%) KP.2.2 (1.9%) MC.16 (1.9%) 1/n

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Raj Rajnarayanan

@RajlabN

2 years

Let's make the messaging crystal clear Assign new names for BA.2.12.1 & BA.4/5 lineages Will be a big boost to crisis communication now! @WHO @CDCgov

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Raj Rajnarayanan

@RajlabN

1 year

#SARSCoV2 Updates Meet #Arcturus 's kids and grand-kids XBB.1.16 (Signature: S:E180V, S:478R) XBB.1.16.1 (S:T547I) FU.1 | Alias of XBB.1.16.1.1 (T3802C) FU.2 | Alias of XBB.1.16.1.2 (C8692T) XBB.1.16.2 (ORF3a:V13L, ORF1a:P926H) XBB.1.16.3 (A2893C)

Raj Rajnarayanan

@RajlabN

1 year

Two new #SARSCoV2 lineages are going viral in social media even without any nicknames— “FU.1 and FU.2” (XBB.1.16* sub-lineages)

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Raj Rajnarayanan

@RajlabN

1 year

I would wear a high quality #mask in a crowed airport. WHY? 1. @CDCgov #COVID19 positivity rate in airports seem to be hovering around 20% (much higher than baseline community positivity rates reported) H/T @TaylorLorenz

Taylor Lorenz

@TaylorLorenz

1 year

I feel so bad for the boomers at home being subjected to this. Never seen a group of people more triggered over something so innocuous

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Raj Rajnarayanan

@RajlabN

10 months

#Holiday #travel #BusyAirports

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Raj Rajnarayanan

@RajlabN

6 months

H5N1 Update | Avian Flu Clade 2.3.4.4b Looked at the newly uploaded Human Sequence (ID: 19027114) from Texas - PB2 contains 👀E627K 👀 in addition to the mutations found in the dairy cattle and wild bird sequences uploaded earlier (used #Fluserver for mutational analysis)

Raj Rajnarayanan

@RajlabN

6 months

Avian Flu Clade 2.3.4.4b update Looked at newly uploaded sequences (GISAID) from Dairy Cattle and birds from Texas Dairy Cows, Blackbirds and Common Grackle have similar mutation pattern Likely source? 1/n

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Raj Rajnarayanan

@RajlabN

1 year

250K “reported” covid cases this week Guess how many missed/unreported cases?

BNO News

@BNOFeed

1 year

This week, more than 250,000 new COVID cases were reported in the U.S., the highest since February

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Raj Rajnarayanan

@RajlabN

1 year

The BA.1 effect It's astonishing how easily people dismiss a peak with a million weekly infections by comparing it to the highest point during the BA.1 variant, despite having robust testing and reporting in place.

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Raj Rajnarayanan

@RajlabN

2 years

Greater than Titan! Seems like BA.2.75 has the potential to outcompete BA.5*/BA.4* and other circulating BA.2 lineages Early days but growth advantage will be clear in a couple of weeks.

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Raj Rajnarayanan

@RajlabN

1 year

#SARSCoV2 #EarlyAnalysis #BA2 Spike mutational profile of newly designated BA.2.86 (BA.X) spotted by @shay_fleishon and @LongDesertTrain BA.2.86 vs XBB.1.5 (This season's vaccine antigen selected by @US_FDA / @CDCgov ) Closely monitored by #VariantHunters and more recently @WHO

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Raj Rajnarayanan

@RajlabN

7 months

It’s would be prudent to update COVID-19 vaccine antigen The fear of “not many will take it” should not take this tool away from “many who will take it” or “needs it” It’s Public Health not popular Health!

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Raj Rajnarayanan

@RajlabN

3 years

New #PANGO designations - BA.2.* BA.2.4Alias of B.1.1.529.2.4, #Singapore lineage BA.2.5Alias of B.1.1.529.2.5, lineage in #Portugal and other countries BA.2.6Alias of B.1.1.529.2.6, lineage in #France and other countries BA.2.7Alias of B.1.1.529.2.7, #USA lineage

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Raj Rajnarayanan

@RajlabN

2 years

Yes, we are watching XBB.1.16 closely Seems to be picking additional mutations already

Maria Van Kerkhove

@mvankerkhove

2 years

. @WHO : New #Omicron Subvariant XBB.1.16 Is ‘One to Watch’ | Health News | U.S. News

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Raj Rajnarayanan

@RajlabN

1 year

"The Great Decoupling" of reported #COVID19 cases from severe outcomes, such as #hospitalizations and #deaths enabled swift end to pandemic regulations. However, it leaves behind several suffering from long COVID, affecting individuals regardless of infection severity....

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Raj Rajnarayanan

@RajlabN

5 months

If public health experts learned anything from the COVID-19 pandemic, it’s that if you keep saying “everything is mild” then “the common people tend not to pay attention at all.”

How the bird flu outbreak is worsening

Recent testing has revealed H5N1 outbreaks are more widespread then previously thought, yet we aren't testing enough

www.salon.com

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Raj Rajnarayanan

@RajlabN

10 months

👀Increase in newly reported #COVID19 Hospitalizations, as JN.1* overtakes all the circulating lineages in #NewYork Source: | @HealthNYGov @nycHealthy | * #SARSCoV2 lineage BA.2.86.1.1; #Pirola group

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Raj Rajnarayanan

@RajlabN

1 year

XBB, the “first major highly immune-evasive” group of COVID variants, “will sweep through China,” but the wave will be “largely invisible” owing to low rates of testing and reporting H/T @ErinMPrater @WellatFortune

China is bracing for a massive new wave of COVID cases. What this means for the rest of the world

Cases of Omicron variant XBB are mounting in China, forming a new wave expected to crest around 65 million cases weekly by the end of June. While COVID remains a global threat, it’s time to “go back...

fortune.com

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Raj Rajnarayanan

@RajlabN

1 year

BA.2.86 Updates 7th BA.2.86 ( #Pirola ) sequence from #Virginia (via @CDCgov Traveler Based Genomic Surveillance Program) Traveler from #Japan ; Asymptomatic Collection date 8/10/23 H/T @OliasDave

Dave McNally

@OliasDave

1 year

We now have a 7th BA.2.86, sampled in the USA on August 10th, so these weekly counts are now:- 2023-07-24 1 of 7659 2023-07-31 3 of 4995 2023-08-07 3 of 1120 2023-08-14 0 of 36

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Raj Rajnarayanan

@RajlabN

1 year

#WasteWater #SARSCoV2 content is trending up again in #USA Closely watching for EG.5.1*, XBB.1.16* signals Source: @BiobotAnalytics 1/n

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Raj Rajnarayanan

@RajlabN

1 year

@GISAID Thanks to all the countries that are still supporting #SARSCoV2 testing and rapidly submitting sequences to public databases like @GISAID #SouthKorea , #USA , #Canada , #China , #Australia , #Singapore , #Austria , #UK , #Spain & #Japan have submitted a lion's share of sequences 🙏

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Raj Rajnarayanan

@RajlabN

2 years

BA.1*, BA.5* and BA.2.75* - Mutational Portfolio

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Raj Rajnarayanan

@RajlabN

2 years

#Omicron family swells to 600+ sublineages! Currently, we are watching "Omicron" BQ*s grand/great grand kids Expected to outcompete other Omicrons in circulation including Omicron.BA5* Recombinants XB* will look to tip the needle in this Family Feud!

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Raj Rajnarayanan

@RajlabN

2 years

XBB.1.16* should definitely be designated as a #VOI by @WHO Growth advantage over current lineages ✅ Spread in multiple-countries ✅ Epidemiological ✅ Clinical: Unknown Add to this #SARSCoV2 Testing ⬇️and Global genomic surveillance ⬇️

Raj Rajnarayanan

@RajlabN

2 years

Tracking XBB.1.16* ( #Arcturus ) over time - Globally Total Sequences: 474 Spotted in #India #USA #Brunei #Singapore #UK #Australia #Japan #NewZealand #Canada #Germany #Denmark #SouthKorea #Malaysia #Ireland #Italy #Austria #China Tracker: 03/22/2023

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Raj Rajnarayanan

@RajlabN

1 year

Thank you Dr. @PeterHotez ! Your constant engagement and attempts to educate people with science and fact-based information is amazing!

Prof Peter Hotez MD PhD

@PeterHotez

1 year

Joe, you have my cell, my email, I’m always willing to speak with you

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Raj Rajnarayanan

@RajlabN

11 months

BA.2.86* (including JN.1) is now being classified by @WHO as a Variant of Interest ( #VOI )

Maria Van Kerkhove

@mvankerkhove

11 months

Update on @WHO classification of #SARSCoV2 BA.2.86 and sublineages (incl JN.1) as a variant of interest (previously listed as VUM) Risk Evaluation from WHO & TAG-VE available here: From our main SARS-CoV-2 variant tracking page:

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Raj Rajnarayanan

@RajlabN

1 month

What the XEC! Recombinant #SARSCoV2 lineage #XEC (recombinant of KS.1.1/KP.3.3) has the potential to outcompete other circulating lineages in #USA (and other countries) More data is needed to provide a reliable growth advantage estimates

Raj Rajnarayanan

@RajlabN

1 month

@GISAID Tracking #SARSCoV2 lineage XEC (recombinant of KS.1.1/KP.3.3) - #30DayTrends 5/n

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Raj Rajnarayanan

@RajlabN

2 years

#NewYork 's XBB.1.5 wave👀 #MaskUp NY! Source:

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Raj Rajnarayanan

@RajlabN

1 year

BA.2.86 #Pirola updates 1. Lot of new sequences uploaded today 2. BA.2.86 with Orf1a:K1973R mutation is now designated as BA.2.86.1 3. SGTF has enable faster screening and upload of seqs 4. Some seqs could be from a single cluster 5. Total seqs: 72

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Raj Rajnarayanan

@RajlabN

1 year

Agree w/ @EricTopol 100% New COVID Booster (XBB.1.5) is only a few spike mutations away from the top circulating SARSCoV2 lineages and should be effective in preventing severe COVID and hospitalizations especially in senior and vulnerable populations (comorbid conditions)

Eric Topol

@EricTopol

1 year

The EG.5.1 #SARSCoV2 variant is gaining in the US and in many places globally. Here's the spike protein cf XBB.1.5 with only 2 new mutations (F456L and Q52H). The new Covid boosters, directed vs XBB.1.5, are closely aligned, should be v effective vs severe Covid, and are overdue

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Raj Rajnarayanan

@RajlabN

1 year

Clear uptick of #COVID19 #Hospitalizations in #NewYork 👀 EG.5.1* ( #Eris )is the top circulating #SARSCoV2 lineage in NY #WasteWater signals ( #Biobot / @CDCgov ) are increasing in #NorthEast #USA region 1/n

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Raj Rajnarayanan

@RajlabN

1 year

BA.2.86 uploaded from #England (London)

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Raj Rajnarayanan

@RajlabN

2 years

BA.2.75* is poised to outcompete other circulating omicron lineages. It would be prudent to check VE of the bivalent vaccines against BA.2.75* Even if its takes additional time to generate few good bridging/supplemental studies or short trial.. its worth the wait.

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Raj Rajnarayanan

@RajlabN

5 months

#H5N1 #LessonLearned - Domestic and Farm cats! Common theme among H5N1 clade 2.3.4.4b infected Cats: - Present multiple symptoms almost immediately - Neurologic, Respiratory, rapid decline leading to death (or compassionate euthanasia) - Pick PB2 mammalian adaptations 1/n

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Raj Rajnarayanan

@RajlabN

1 year

“A lot of people think ‘endemic’ means end,” but it actually means that it’s transitioned to become a permanent threat" - @asosin H/T @DohenyKathleen @WebMD

Kathleen Doheny

@DohenyKathleen

1 year

What happens after May 11? #PHE #COVID19 #pandemic @RajlabN @asosin

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Raj Rajnarayanan

@RajlabN

6 months

#H5N1 updates A person* in the United States has tested positive for highly pathogenic avian influenza (HPAI) A(H5N1) virus (“H5N1 bird flu”), as reported by Texas and confirmed by CDC. *contact w/ sick cows reported

CDC Newsroom

Press releases, advisories, telebriefings, transcripts and archives.

www.cdc.gov

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Raj Rajnarayanan

@RajlabN

1 year

Two new #SARSCoV2 lineages are going viral in social media even without any nicknames— “FU.1 and FU.2” (XBB.1.16* sub-lineages)

Federico Gueli 🏳️

@siamosolocani

1 year

Great work by @CorneliusRoemer in designating a lot of new lineages tonite. also new sublineages of XBB.1.16 (.2 and FU.s), more 478Rers and 456Lers

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Raj Rajnarayanan

@RajlabN

1 year

Just got my #COMIRNATY 12+ (COVID) 23-24 SDV aka XBB.1.5 @pfizer #booster (“updated”) @ @Walgreens

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Raj Rajnarayanan

@RajlabN

2 years

Lineages to watch 1. BQ.1* 2. BQ1.1* 3. BA.2.75.2* 4. XBB - Recombinant of BJ.1 and BM.1.1.1 5. BA.2.3.20 All lineages have appreciable ACE2 affinity; 1-4 are highly immune evasive; 1 & 2 evade many therapeutics - #Evusheld and #Bebtelovimab

'The tools are getting picked off’: An ever-mutating mix of COVID variants means fewer and less...

One up and coming variant renders society’s last universal COVID antibody drug powerless, experts say. Another variant isn’t far behind it.

fortune.com

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Raj Rajnarayanan

@RajlabN

3 months

#H5N1 #AvianFlu updates Quick Analysis of the sequence of H5N1 (clade 2.3.4.4b) #Colorado human case uploaded to @GISAID PB2 mutations: T58A, V109I, V139I, E249G, E362G, K389R, D441N, V478I, V495I, M631L*, V649I, M676A * Dairy cattle outbreak signature 1/n

Rick Bright

@RickABright

3 months

🚨Breaking news. 1st sequence of the #H5N1 viruses from Colorado human cases reported over weekend posted in @GISAID by @CDCFlu (in only 3 days is very fast). See link below for trees. Interestingly, the virus appears to cluster w/ viruses from dairy cows & cow milk and NOT

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@RajlabN

1 year

BA.2.86* #Pirola Updates #UnitedKingdom has uploaded 27 sequences to GISAID today- majority of these sequences were from a single care-home outbreak. While this is not surprising for a lineage like BA.2.86*, the attack rate of ~87% is still high. 1/n

Dr Duncan Robertson

@Dr_D_Robertson

1 year

Details of the BA.2.86 Care Home outbreak - attack rate of 86.6%

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Raj Rajnarayanan

@RajlabN

3 months

#H5N1 virus, liked to dairy cattle outbreak, has the ability to bind to sialic acids found in human upper airways. Not able to effectively transmit in an animal model of respiratory transmission We are probably few mutations away Time to act is now!!

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@RajlabN

10 months

Time to take JN.1* seriously Already produced a few kids worth monitoring 1) XDD - JN.1*/EG.5.1.1* recombinant (spotted by @JosetteSchoenma ) 2) #SLip - Picked up Spike F456L adjacent to L455S ( @LongDesertTrain ) 3) Few Non-Spike mutations described in

Open Discussion about BA.2.86 ( BA.2.86 = 38890/ JN.1 = 27237/ XDD = 301 / XDK = 55 ) · Issue #606...

edited November 20** TRACKER BA.2.86: -C6541T,A7842, C8293T, G8393A (new query thx to @aviczhl2 ) JN.1 QUERY: C18894T, T15756A, A7842, -C6541T XDD Query : C6541T, A7842, T15756A, A26275G XDK Query:...

github.com

Raj Rajnarayanan

@RajlabN

10 months

Tracking #SARSCoV2 #Lineages - Globally |11/25/23 Top lineages - #30DayTrends ( #G30 ): HV.1 (16.4%)⬆️ HK.3 (10.5%) JN.1 (4.8%)🚀👀 EG.5.1.1 (4.7%) JG.3 (4.4%) JD.1.1 (3.8%) EG.5.1 (3.5%) EG.5.1.3 (2.7%) FL.1.5.1 (2.6%) BA.2.86.1 (2.5%) Track 1/n

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Raj Rajnarayanan

@RajlabN

11 months

"Experts are closely monitoring JN.1 (BA.2.86.1.1)" “.. has all the features of becoming a dominant lineage” “With travel and the holidays coming up, we know that it's gonna spread everywhere" H/T @hlavinka_e @Salon

Has the winter COVID variant arrived?

JN.1 isn’t yet a cause for alarm, but that could change, serving as a reminder that COVID always has new tricks

www.salon.com

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Raj Rajnarayanan

@RajlabN

2 years

#Omicron family swells to 500+ sublineages! Currently, we are watching "Omicron" BQ.1.1* Expected to outcompete other Omicrons in circulation including Omicron.BA5* Omicron.BJ1/ .1.1.1 recombinant XBB might give a tough fight to .*

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@RajlabN

3 years

@COVIDnewsfast @DrEricDing #Poland (44% share of BA.2 sequences carry H78Y mutation), #Sweden (38%) and #Denmark (28%) are BA.2+Orf3a:H78Y hotspots. Several European countries are catching up!

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@RajlabN

2 years

#Omicron family swells to 653+ #sublineages ! Currently, we are watching "Omicron" Great-Great-Great grand kids.. especially the recombinant family members Expected to outcompete other circulating Omicrons including Omicron-BQ* XBB.1.5* poised to take over North America soon!

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@RajlabN

11 months

BA.2.86* #Pirola Updates Meet new members of BA.2.86 family JN.2.1, JN.5.1, JN.9, JN.10

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@RajlabN

6 months

#H5N1 Clade 2.3.2.1c - #Vietnam New sequence from Khanh Hoa has intriguing #avianflu reassortment and PB2-E627K mammalian adaptation signature. PB2-E627K was absent in previously submitted avian sequences. Case description:

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Raj Rajnarayanan

@RajlabN

1 year

Status of Genomic Surveillance in the World Global genomic surveillance is significantly down & the negative impact of Global & National Emergency End Declarations is evident! Source: GISAID

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Raj Rajnarayanan

@RajlabN

1 year

BA.2.86 #Pirola Updates BA.2.86 sequence uploaded from #Texas / #Houston Sample collection date 8/22/23 BA.2.86 Sequence from #Canada / #BritishColumbia (reported earlier) Sample collected in August 2023 (Day not provided)

Tracking BA.2.86* Lineage Over Time

public.tableau.com

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Raj Rajnarayanan

@RajlabN

2 months

As of now, there is no official announcement from the @CDCgov or @US_FDA regarding the timing of new #COVID19 vaccines or specific recommendations (in the interim) Agree 100% with @PeterHotez Need updates on the guidelines from CDC/FDA ASAP! 3/n

Prof Peter Hotez MD PhD

@PeterHotez

2 months

A common question I’m being asked is whether to hold out for the new Covid vaccines or just go ahead and get another XBB while transmission is high now? It would help if CDC or FDA gave us a heads up on timing and any recommendations.

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@RajlabN

1 year

BA.2.86* #Pirola updates Meet new sub-lineages: BA.2.86.1(ORF1a:K1973R) JN.1BA.2.86.1.1 (S:L455S, ORF1a:R3821K, ORF7b:F19L) JN.2BA.2.86.1.2 (ORF1a:Y621C) JN.3BA.2.86.1.3 (ORF1a:T2087I) BA.2.86.2(ORF7a:E22D) BA.2.86.3(C222T, C1960T, T12775C) JQ.1BA.2.86.3.1 (S:T95I)

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@RajlabN

1 year

BA.2.86 ( #Pirola ) updates 8th BA.2.86 sequence is uploaded from #Mpumalanga , #SouthAfrica Specimen collection date: 7/28/2023 via baseline surveillance 1/n

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@RajlabN

4 months

one by one the map is filling up like a bingo card

BNO News

@BNOFeed

4 months

H5N1 bird flu found at 3 more dairy farms in Idaho, taking the state's total to 22

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@RajlabN

1 year

Looks like @Novavax updated vax approval is not far behind...

Novavax

@Novavax

1 year

Doses of Novavax’s updated protein-based #Covid vaccine arrived in the US today and will be ready for release pending EUA and recommendation from the @CDCgov and ACIP. Novavax will present the latest data on its vaccine at ACIP’s Sept.12, 2023 meeting.

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@RajlabN

1 year

BA.2.86 shows higher infectivity than all other #omicrons tested in Calu-3, a human airway epithelial cell line and a good preclinical respiratory model. H/T @ShanLuLiu1

Shan-Lu Liu

@ShanLuLiu1

1 year

We find that BA.2.86 has low infectivity in 293T-ACE2 cells, similar to @yunlong_cao results, but high infectivity in CaLu-3 cells - actually the highest among all Omicron variants tested.

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@RajlabN

1 year

BA.2.86 #Pirola updates from #Ohio , #USA Sample Collection date: 2023-07-29 H/T @OliasDave

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@RajlabN

2 years

Tracking XBB.1.16* ( #Arcturus ) over time - Globally Total Sequences: 205 Spotted in #India , #USA , #UnitedKingdom , #Singapore , #Australia , #SouthKorea , #Denmark , #Italy , #Ireland , #Germany , #Canada , #Austria Tracker: Updated: 03/17/2023

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@RajlabN

2 years

A sandwich to go with the variant soup! Meet Omicron's new family member: XBL - A recombinant sandwich - XBB.1*/BA.2.75*/XBB.1* mainly in #Malaysia Only a few sequences but Spike looks like XBB.1.5

XBB.1*/BA.2.75*/XBB.1* recombinant with S:F486P (8 seq, Malaysia) · Issue #1532 · cov-lineages/pa...

Proposal for a recombinant lineage Earliest sequence: 2022-11-24 (Malaysia) Countries detected: Malaysia (6), Japan ex-Malaysia (1), Singapore ex-Malaysia (1) Potential breakpoints: 406-3795 (nsp1-...

github.com

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Raj Rajnarayanan

@RajlabN

9 months

“ #COVID19 hospitalizations increased 20.4% the week ending December 30, 2023. In that same period, deaths went up by 12.5%, with COVID-19 deaths accounting for 3.6% of total deaths in the United States.”

CDC

@CDCgov

9 months

CDC continues to track the rise of the JN.1 variant, which now accounts for 62% of circulating COVID-19 variants in the U.S. Existing vaccines, tests, and treatments work against JN.1.

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@RajlabN

6 months

Avian Flu Clade 2.3.4.4b update Looked at newly uploaded sequences (GISAID) from Dairy Cattle and birds from Texas Dairy Cows, Blackbirds and Common Grackle have similar mutation pattern Likely source? 1/n

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@RajlabN

2 years

#SARSCoV2 updates Meet new #recombinant sub-lineages EG & EK Yup! maxed X** letter codes and now moving to EG*, EK* etc EG.1 |Alias of XBB.1.9.2.1 | Signature mutations: S:Q613H, N:L219F EK.1 | Alias of XBB.1.5.13.1 | Signature mutations: S:K417S 1/n

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@RajlabN

9 months

Closely watching JN.1.6.1 (Signature mutation Spike R346T). Spike R346T is one of the legacy mutations! It clearly stands out in the ACE2 binding vs Immune escape charts! 1/n

Raj Rajnarayanan

@RajlabN

9 months

#COVID19 #VariantDashboard - #USA #SARSCoV2 #Lineages #30DAYTRENDS JN.1 (27.7%)👁️ HV.1 (14.9%)⬇️ JN.1.4 (11.5%)⬆️👀 JN.1.1 (5.9%) JD.1.1 (2.8%) HK.3 (2.4%) JG.3 (1.9%) FL.1.5.1 (1.4%) BA.2.86.1 (1.3%) JN.1.2 (1.3%) Tracker: | 01/11/24 1/n

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@RajlabN

2 years

XBB.1.5 is poised to outcompete all other circulating lineages in #England , #UnitedKingdom including CH.1.1* and BQ.1*/BQ.1.1*(unless something else pop up). (Growth advantage charts generated w/ @GenSpectrum )

Raj Rajnarayanan

@RajlabN

2 years

Tracking XBB.1.5* lineage over time in Europe | 01/09/2023 Emerging hotspots #UnitedKingdom , #Denmark , #Austria ^^, #France , #Germany , #Netherlands ^^ data includes targeted surveillance as well

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@RajlabN

4 months

Tracking #SARSCoV2 #Lineages - Globally |06/08/24 Top lineages - #30DayTrends ( #G30 ) KP.2.3 (8.7%) KP.2 (8.7%) KP.3.1 (7.7%) KP.3 (6.2%) KP.3.2 (5.1%) LB.1 (5%) KP.1.1 (4.9%) Track: 1/n

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@RajlabN

1 year

#WasteWater #SARSCoV2 content is trending up again in #NE #USA Closely watching for EG.5.1*, XBB.2.3* & XBB.1.16* signals in NE USA Source: @BiobotAnalytics H/T @MAPdonnelly 1/n

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@RajlabN

1 year

Status of Genomic Surveillance in the World Global genomic surveillance is significantly down & the negative impact of Global & National Emergency End Declarations is evident! Source: GISAID; updated 8/23/2023

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Raj Rajnarayanan

@RajlabN

2 years

XBB.1.9.1 spotted in #China | Qinghai / Xining - Specimen collection date 2/23/23 Sichuan / Meishan - Specimen collection date 2/19/23 XBB.1.9.1 is expected to have a significant growth advantage over other circulating variants (BA.7.14*, BA.5.2.48* & BA.5.2.49*) and XBB.1.5*

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@RajlabN

2 years

XBB.1.5 deserves a name.. @WHO will bell the cat?

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@RajlabN

2 years

IT AIN'T OVER..

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@RajlabN

1 year

Good news! @moderna_tx XBB.1.5 #COVID19 vaccine generates a strong human immune response against BA.2.86 ( #Pirola )

Moderna

@moderna_tx

1 year

We announced today clinical trial data for our updated COVID-19 vaccine candidate in humans against BA.2.86 (Pirola), a variant under monitoring. Read more ⬇

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Raj Rajnarayanan

@RajlabN

1 year

BA.2.86 #Pirola updates New BA.2.86 sub-lineage designated - BA.2.86.1(Signature mutation: ORF1a:K1973R) A BA.2.86.1 sequence uploaded today from #Colorado Sample collection date: 8/19/2023

Tracking BA.2.86* Lineage Over Time

public.tableau.com

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@RajlabN

2 years

New York's XBB.1.5 wave #MaskUP #NewYork

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@RajlabN

2 years

Got #Boosted with #Bivalent Omicron.BA5/OG #Vaccine ( @pfizer / @BioNTech_Group ) When are you getting yours?

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@RajlabN

9 months

Closely monitoring newly reported #COVID19 #Hospitalizations in #NewYork state ( @HealthNYGov ) Already crossed previous year's peak, poised to cross Jan 2021 peak if this trend continues... #MaskUP , #Ventilate and get #Boosted !

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@RajlabN

1 year

#SARSCoV2 #VariantDashboard #Japan Top lineages ( #30DayTrends ): XBB.1.16 (15.2%) EG.5.1 (11.7%)👀⬆️ XBB.1.5 (4.4%)⬇️ XBB.1.16.1 (4.3%) FL.4 (4.2%) XBB.1.9.1 (3.8%) XBB.1.16.2 (3.6%) EG.1 (3.1%) XBB.2.3.2 (2.9%) FU.1 (2.5%) |Updated 07/21/2023

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@RajlabN

3 months

Tracking #SARSCoV2 #Lineages - Globally |07/20/24 Top lineages - #30DayTrends KP.3.1.1 (14.2%)👀 KP.2.3 (7.9%) KP.3.1 (7.8%) KP.3.3 (7.7%) KP.3.2 (3.8%) KP.3 (3.4%) KP.3.1.4 (3.4%) KP.2 (3.4%) LB.1 (2.7%) KP.2.2 (2.7%) Track #G30 : 1/n

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@RajlabN

2 years

Closely following this...

BNO News

@BNOFeed

2 years

At least 585 sea lions in Peru have died of H5N1 bird flu, the environment ministry says

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@RajlabN

10 months

Global #SARSCoV2 #VariantDashboard | #15DayTrends - updated 12/10/2023 JN.1 has surpassed all major circulating lineages, yet in certain regions, it hasn't claimed the top spot. Given current knowledge, it's anticipated to outcompete soon. 1/n

Raj Rajnarayanan

@RajlabN

10 months

Tracking #SARSCoV2 #Lineages - Globally |12/09/23 Top lineages - #30DayTrends ( #G30 ): HV.1 (16.1%)⬇️ JN.1 (9.6%)🚀👀 HK.3 (6.8%)⬇️ JG.3 (4.5%) JD.1.1 (3.8%) JN.1.1 (3.7%)⬆️👀 BA.2.86.1 (3.1%) EG.5.1.1 (2.9%) JN.2 (2%) ⬆️ 1/n

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@RajlabN

2 years

#COVID19 #VariantDashboard - #UnitedStates XBB.1.5 is the top circulating lineage in USA TOP lineages (15-DAY TRENDS): 18.1% XBB.1.5👀🚀 17.1% BQ.1.1 10.2% BQ.1 4.4% BQ.1.22 4.3% XBB.1 2.2% BQ.1.1.3 Tracker: #OmicronUpdates 12/26/22 1/n

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@RajlabN

1 year

Predicted Immune Escape vs ACE2 Binding Scores (Relative to BA.2) of #Omicron BA.X (from Israel/Denmark) and circulating SARSCoV2 lineages BA.X is expected to bind to host ACE2 receptor similar to XBB.1.5 and immune escape better than XBB.1.5 Tracker:

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Raj Rajnarayanan

@RajlabN

9 months

Wish you and your family a Happy and Healthy New Year 2024

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@RajlabN

2 years

SARSCoV2 BA.2 #subvaraints carrying #MainProtease ( #MPro ) mutations associated with reduced #nirmatrelvir ( #Paxlovid ) activity Top #NSP5 (MPro) mutations: H164N, G15S, T135I Should investigate if these NSP5 mutations are also associated with Paxlovid rebound. 1/n

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@RajlabN

1 year

Excellent news! @Novavax 's updated #COVID booster induced neutralizing responses to emerging subvariants EG.5.1 ( #Eris ) and XBB.1.16.6 ( #Arcturus sub-lineage) with Spike F456L in addition to XBB.1.5 ( #Kraken ), XBB.1.16 ( #Arcturus ) and XBB.2.3 ( #Acrux ) H/T @HarrySpoelstra

Harry Spoelstra

@HarrySpoelstra

1 year

The good news for today!! Data have shown that Novavax's COVID booster induces broadly neutralizing responses against XBB subvariants, including EG.5.1 and XBB.1.16.6

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@RajlabN

1 year

BA.2.86 ( #Pirola ) updates According to the @MichiganHHS "7 cases of the highly mutated BA.2.86 strain have been found worldwide including one case in Washtenaw County. The person with the BA.2.86 case is an older adult with mild symptoms" @wcpublichealth

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Raj Rajnarayanan

@RajlabN

2 years

@EricTopol @Mike_Honey_ BA.2.75 is already in the USA. Two sequences were uploaded in GISAID yesterday with sample collection dates 6/14/22 (Washington) and 6/15/22 (California)

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@RajlabN

1 year

XBB.1.5 booster and recent infections may offer some protection against BA.2.86 ( #Pirola ) Based on previously available data, they are expected to work against current top lineages EG.5.1 ( #Eris ), FL.1.5.1 ( #Fornax ) etc Get boosted as soon as XBB.1.5 booster is available 1/n

Ben Murrell

@BenjMurrell

1 year

Real-time data update: we've got our first BA.2.86 (see red arrow) neutralization results. Short 🧵with much credit to @DannySheward and the rest of the team.

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Raj Rajnarayanan

@RajlabN

2 years

#CoronaVirusUpdates #China 20 new SARSCoV2 sequences were uploaded from #Beijing today! Mostly BF.7 and BA.5.2

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Raj Rajnarayanan

@RajlabN

2 years

. @Walgreens 's #COVID19 #Index Test positivity is > 40% (treat this like an election exit poll - includes tests performed at Walgreens sites nationwide) 1) We are still riding the #UglyPeak 2) Potentially many missed and unreported cases 3) Pandemic is far from over!

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@RajlabN

6 months

Closely watch the rise of recombinant lineage XDQ.1 in #Japan (Signature mutation Spike A475V) 1/n

Raj Rajnarayanan

@RajlabN

6 months

@GISAID XDQ.1* (Recombinant lineage of BA.2.86.1 and FL.15.1.1) is the top circulating lineage in #Japan

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Raj Rajnarayanan

@RajlabN

9 months

Before tackling a new health threat, such as 'Disease X,' it is essential to openly acknowledge and analyze the shortcomings and gaps in our response to the current ongoing pandemic. 1/n

Tedros Adhanom Ghebreyesus

@DrTedros

9 months

‘Disease X’ is a placeholder for an unknown pathogen that could cause a global emergency. History has taught us that we must anticipate new threats. Failing to prepare leaves the world prepared to fail. At #WEF24 today, I spoke about @WHO initiatives that are supporting

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@RajlabN

3 years

#CoronovirusUpdates #potential new lineage (sub-branch) - BA.2 + S:I210T mutation Observed increasing % of this mutation among BA.2.2 (S:I1221T) sequences from #UnitedKingdom Right now, 88% of BA.2.2 from UK contains S210T This mutation is not present in BA.2.2 from #HongKong

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Raj Rajnarayanan

@RajlabN

2 years

Closely watching #China ’s #COVID wave

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Raj Rajnarayanan

@RajlabN

2 years

Have a look at #California 's COVID19 test positivity! 👀 Source: @nytimes

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Raj Rajnarayanan

@RajlabN

5 months

#H5N1 updates Looks like there is a cattle sequence with PB2 E627K (present in the sequence from the human isolate) 1/n

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@RajlabN

2 months

Tracking #SARSCoV2 #Lineages - Globally |08/17/24 Top lineages - #30DayTrends KP.3.1.1 (28.2%)👀 KP.2.3 (10%) KP.3.3 (7.6%) KP.3.1 (5%) LB.1 (2.5%) LB.1.7 (2.5%) KP.2.2 (2.4%) KP.2 (2.3%) KP.1.1.3 (2.1%) --- XEC (0.4%) Track #G30 : 1/n

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@RajlabN

1 year

Thank you #VariantTrackers @LongDesertTrain and @shay_fleishon ! A "BA.x drifter" lineage identified from #Israel and #Denmark . On time for another SGTF flip? Following this closely👀

Ryan Hisner

@LongDesertTrain

1 year

Two more sequences of this 2nd-generation BA.2 lineage just showed up in Denmark. This is the real deal. There are slight differences between the three sequences, but they are nearly identical. Below is my preliminary summary of the mutations it has on top of BA.2. 1/2

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@RajlabN

1 year

A clear uptick of #hospitalizations in #NewYork FL.1.5.1*, EG.5.1*, XBB.1.16* are the top circulating #SARSCoV2 lineages Source:

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@RajlabN

10 months

Tracking #SARSCoV2 #Lineages - Globally |12/23/23 Top lineages - #30DayTrends ( #G30 ): JN.1 (25.7%)🚀👀 HV.1 (13.2%)⬇️ JN.1.1 (7%)⬆️ HK.3 (4.6%) ⬇️ BA.2.86.1 (3.6%) JG.3 (3.5%) JD.1.1 (3.5%) JN.2 (2.2%) EG.5.1.1 (1.3%) ⬇️ Tracker: 1/n

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@RajlabN

1 year

Excellent news! #XBB #Booster in the market by September H/T @Novavax @Alexander_Tin

Alexander Tin

@Alexander_Tin

1 year

Ahead of earnings today, @Novavax says now begun @US_FDA submission for updated COVID vaccine targeted at XBB "plan to be in market by September" "manufacturing at commercial scale in support of our plan to deliver our vaccine on time for the fall"

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@RajlabN

6 months

Be aware of the recent detection of highly #pathogenic #avian #influenza ( #HPAI ) in dairy cows and goats in several states in the #UnitedStates This is the first time HPAI has been found in dairy cattle and only the second time in ruminants. 1/n

Bird flu in US dairy: What we know so far plus tips for producers (updated)

We round-up the facts around the HPAI outbreak affecting some US dairy herds, what farmers should do now to bolster biosecurity, and what all this means for milk supply and public health.

www.dairyreporter.com

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