Jasnah Kholin - 8964 - ACAB @wanderer_jasnah Twitter profile

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

4 years

@dreamboum @Itmechr3

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

4 years

it's called a cutoff, you colonial dipshit. every cycle you double your primer-matching DNA. if after fourty repeats of this you have still not detected viral DNA (here reverse-transcribed from RNA first), it's generally agreed upon your viral loads see too low to be infectious.

Elon Musk

@elonmusk

4 years

Lab I just spoke to said cov2 PCR detection (N1 & N3 genes) below 30 cycles is reliable & above 40 cycles is not

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

1 year

oh man check out this absolute blast from the past i found:

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

none of this is fucking true, this is a bog-standard BA.2 Omicron lineage (multiple sequences up on GISAID). as has been noted to death by many people incl. myself, this death rate is 100% a factor of a dismal elderly vax rate (<40% in 80+, <15% in RCHEs).

COVID NEWS NETWORK

@COVIDnewsfast

2 years

The entire planet needs to be paying attention to Hong Kong. Catastrophic loss of life is underway, with an unknown BA 2 variant emerging out of here. 🚨🚨🚨🚨🚨

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

too many people on here have either forgotten what a #COVID19 ward looked like in 2020 or just flat-out never seen one & good lord does it *EVER* show.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

once again. if i have *any* choice in the matter i want my primary immunity to be via vaccination. every time. no matter the virus, age, complication rate from the virus at that age. if there's a vaccine for it i'm taking it.

Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

as a virologist, if i have the choice of getting immunity from a virus via infection, or vaccination that is available to me, i'm picking vaccination. every time. no matter what the virus.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

@BallouxFrancois with all due respect, why are we exposing them before vaccinating them?

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

@dagger0621 still think is the most absurd example of this.

Dr Charlotte Lydia Riley

@lottelydia

5 years

I love an algorithm-designed classic book cover, and this one is really something.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

to the various people who took one look at that one particular paper & somehow came to the conclusion that Omicron doesn't induce immunity against itsself, what do you think caused the BA1/BA2 waves to stop growing, magic elves?

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

this is idiotic.

BNO News

@BNOFeed

3 years

Israel's Health Ministry says vaccine passports will expire 6 months after an individual's 2nd or 3rd dose

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

1 year

extremely mild take: cervical cancer is, almost entirely, now a vaccine-preventable disease. if you are arguing against HPV vaccination, you are quite plainly arguing for more cancer.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

with all due respect this is simply not even remotely true. even if VE against symptoms is indeed reduced saying the vaccine is *useless* after 6-8 months is just factually incorrect.

Eric Topol

@EricTopol

3 years

a notable quote

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

4 years

"huh, i wonder what could explain East Asia's success w/keeping COVID19 contained? could it be robust, well-funded public health systems, many which were recently battle-tested on SARS or MERS? nah, it's got to be random mystery genetic factors! somehow!!!"

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

quick glance at B.1.640.2 before anyone asks me about it: it's basically B.1.1.7 w/a large Spike NTD deletion. i see no reason to expect this to have a fitness advantage over Delta *or* Omicron. meh.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

again, 1-2 week incubation period & it takes generally another 1-2 weeks for you to hit ICU, so the deaths we are seeing now are from cases around the New Year, which would've been pre-vaccination. i feel like this point is being massively understated inexplicably.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

i really do not understand the sheer amount of surprise from so many that widespread reinfections are possible every year or so. like, the other 4 HCoVs do so via antigenic drift periodically so why would *this* HCoV be any different?

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

this is some of the worst messaging i have *EVER* seen in my life. the tweet literally contradicts itsself; how is a non-specialist supposed to make *ANY* sense of shit like this?!?

CDC

@CDCgov

3 years

Right now, there’s not enough data to support getting an mRNA #COVID19 vaccine (COMIRNATY/Pfizer-BioNTech or Moderna) booster after getting Johnson & Johnson’s (J&J) vaccine. However, people who received J&J will probably need a booster dose. More: .

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

OH FOR THE LOVE OF ALL THAT'S HOLY IT'S NOT "AIRBORNE HIV" FFS.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

10 months

the extent to which people seem to have just fucking *completely* memory-holed the horrors of 2020 is genuinely mystifying. & horrifying in its own right.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

i think a lot of people are misunderstanding the mechanism behind "shift to endemicity" in a CoV. it's not at all due to the *virus*. yes, endemic HCoVs have certain mutations (such as a preference for closed RBDs on Spike where the CTD is the RBD) but those are from...

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

take it from someone living in a place that went from (relatively) free to police state in *three years*: this is how fast it happens. fight. now. b/c they're not stopping otherwise, & they sure as hell aren't going to slow down on their own.

kyle

@notkent

2 years

Roe V. Wade could represent a tidal shift in American society This was so unthinkably impossible to happen that nothing should be dismissed or underestimated moving forward The speed of the collapse is bewildering

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

4 months

@dieworkwear scarf dude is just jealous he will never look this cool: (seriously tho really curious on your thoughts on scarves; even as a woman i think that scarf style wouldn't be too different between genders or am i wrong?).

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

1 year

okay, here we go. so as i've said numerous times, DEFUSE could not have given us SARSCoV2 b/c: 1) there is no evidence that WIV had a viable progenitor sequence (something very clearly stated in the ODNI report) 2) it was not funded, i.e. the grant proposal went nowhere

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

so tired of seeing "we're back to March 2020" takes. not with this level of population immunity, fuck no. like god fucking damnit you can be terrified while still having a grip on reality how is this so difficult.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

i fucking swear, trying to set the record straight wrt the massive churn of terrible #SARSCoV2 papers that now are increasingly hitting the terrible #SARSCoV2 news cycle & inciting panic is increasingly feeling like trying to bail out an ocean liner w/a teaspoon.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

4 years

hoo boy. this is not a good paper at all. it pains greatly me to have to debunk claims made by a former colleague whom i respected a lot, but... yeah. here we go.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

omfg this tweet is still up? amazing.

Global Times

@globaltimesnews

4 years

Police in Central China's Wuhan arrested 8 people spreading rumors about local outbreak of unidentifiable #pneumonia . Previous online posts said it was SARS.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

folks there is too little hospitalization data for Omicron, let alone data that has vaccination status, that it is literally impossible to empirically compute a VE against hospitalization for it at this moment in time. can y'all please fucking stop until we have that data???

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

@krislc the correct national anthem.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

it's fucking lineage C.37, so L452Q & F490S on a D614G Spike (plus usual NTD & nsp3/4/6 crap). i know NYpost is total garbage but this is journalistic malpractise of the highest grade. (also nothing at P681 or even anywhere near FCS for that matter so i'm not even blinking).

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

anyone trying to throw the words "vaccine escape" around has to explain to me how a non-integrating virus incapable of nuclear latency is supposed to escape a polyclonal *ADAPTIVE* immune response or shut the fuck up.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

if this were even remotely correct hospitals would be *overflowing* rn in much of the world. come on. think more.

Michael Lin, MD PhD 🧬

@michaelzlin

2 years

Time for a new vax. Even for hospitalization, VE of 3x Pfizer stops to ~55% after 3 months against Omicron

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

it is 2021, 2 years into this pandemic, we've known about HCoVs since 1965 OH & WE HAVE YEARLY FLU SEASONS. HOW HAS *ANTIGENIC DRIFT* BECOME THE LATEST CONCEPT IN IMMUNOLOGY THAT WE ALL COLLECTIVELY FORGET ANOUT THEN PANIC ABOUT AS WE REDISCOVER IT?!?!?!?!?!?!?!?!?!?!?!?!?!?!?

Sky News

@SkyNews

3 years

"Herd immunity may not even be possible to reach with this virus". 'By the time you get enough people vaccinated, you get a new variant that arises that escapes previous immunity', says clinical epidemiologist Dr Deepti Gurdasani. #COVID19 :

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

@CT_Bergstrom i'll take "proxy for socioeconomic status" for $500, Carl.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

i got "LongCOVID of the brain" just from reading that post.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

folks, #SARSCoV2 is already a bad enough virus, you don't *need* to make shit up to make it even worse somehow.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

i know i'm a bit late to the party, but to anyone who thinks #SARSCoV2 FCS is engineered, if you were actually engineering in an FCS: 1) you'd use something you've seen before, say RRSRR in HKU1. turns out this particular one *does* show up in some strains of FIPV but it's rare.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

*puts on hard hat, respirator, asbestos gloves* (hey i haven't used these in awhile!) okay. i'm seeing the same claims on my TL over & over that quite frankly, make no sense. & now they're starting to broken-telephone into each other so: my thoughts on vaccine schedule.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

1 year

so uhh... genetic info has been released on the Oct. 2022 H5N1 outbreak in farmed mink & it's uhh... let's just say nature is trying a little too hard to replicate Fouchier's H5N1 study: like, we need to have vaccines for this thing at the ready.

Highly pathogenic avian influenza A(H5N1) virus infection in farmed minks, Spain, October 2022

In October 2022, an outbreak in Europe of highly pathogenic avian influenza (HPAI) A(H5N1) in intensively farmed minks occurred in northwest Spain. A single mink farm hosting more than 50,000 minks...

www.eurosurveillance.org

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

at this point there's a consistent clear picture that Omicron has massively decreased fusogenicity when taking the TMPRSS2-dependent path & also that infectivity via that route is correlated w/LRT pathogenicity.

The Sato Lab (Kei Sato)

@SystemsVirology

3 years

In sharp contrast, Omicron is less fusogenic (left panel) and its spike is faintly cleaved (right panel). Our data suggest that the efficacy of spike protein cleavage, fusogenicity and pathogenicity are well correlated each other. 3/5

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

the speed & extent of this pivot is just insane. from massively overstating the dangers of this to most (as long as they are vaccinated) to almost going full GBD in literally weeks. almost as if much of this never was about public health to start.

Global Times

@globaltimesnews

2 years

#Omicron is not scary, and about 99% of those infected with Omicron can fully recover within 7-10 days, China's top respiratory disease expert Zhong Nanshan said at a national academic video conference of respiratory diseases on Friday.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

so i got this far before i had to stop reading this blog post b/c i was laughing so hard i nearly fainted.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

i am okay.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

4 years

please just shut up & read a textbook on PCR before you continue this drivel.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

7 months

what -- & i cannot stress this enough -- the absolute fuck would compel someone to say this: (publicly, no less!)

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

EFFICACY DROP

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

*really* wish people would categorize any potential intrinsic severity reductions in Omicron against D614G Wuhan-Hu-1 & not Delta. like yeah, it's likely *somewhat* less severe than Delta. that's not a high bar, Delta is *horrifying*.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

so a bunch of people have asked me about my thoughts on AY.4.2, so here we go. it's Delta plus a mutation in the second NTD loop. anyhow, let's go thru the usual...

David States MD PhD

@statesdj

3 years

Not looking good for the hope that delta + S:Y145H is just a founder effect or fluctuation, its prevalence continues to increase in the UK, now up to ~8%. Only a matter of time before this hits the US and rest of the globe

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

where the hell did public health messaging go so wrong that it seems a nontrivial amount of the public believes that "vaccine-resistant" viruses are a thing you *can* have happen??? (it's not. at all).

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

🔔oh for fuck's sake.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

scalding take: highly vaccinated countries are currently in the process of undergoing a transition to endemicity, perhaps in some like the UK a bit more rapidly than i think they should, but in the end people *will* need to update their mental model of a #SARSCoV2 infection.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

after the last two weeks i literally have negative infinity fucks left to give so if you're wanting spicy takes, you're in for a treat.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

oh for fuck's sake.

TMZ

@TMZ

2 years

Monkeypox Cases Are Exploding, We Should Be Worried Says Dr. Eric Feigl-Ding

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

when people tell me that #SARSCoV2 is unlike other HCoVs "since there's no indication that it will stop evolving & changing in fitness"... what the bloody hell do you think the other 4 HCoVs in circulation do?!? just exist in perfectly preserved evolutionary stasis for centuries?

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

good lord, the comments to this are... christ. anyway: yes, for healthy young *vaccinated* adults, reinfections from antigenically-drifted variants will, on average, be less severe. we've already gone from "the entire hospital is a #COVID19 ward" to flu-level morbidity ffs.

CBC News

@CBCNews

2 years

Scientists say that for most healthy adults, COVID-19 reinfections should get easier to deal with as the immune system gains repeat training on how to handle the pathogen.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

literally *all* of these viruses w/the exception of HCV become permanently *LATENT* in cells & actively mess w/both anti-apoptopic factors & the cell cycle in order to maintain persistence. this can go awry in the predictable manner. #SARSCoV2 does not establish latency.

Peter English #FBPE

@petermbenglish

2 years

Some viruses are cancer-causing ("oncogenic"). HPV and anogenital and head and neck cancers, Hepatitis B and C viruses and liver cancer; Epstein Barr virus and lymphomas etc… I'd be surprised if SARS-CoV-2 doesn't join the list.

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@wanderer_jasnah

3 years

astounding. certainly would explain everything but now makes me wonder how this couldn't've been caught *before* the multitude of breathless, panicked press releases about "waning immunity" & whatnot.

Dvir Aran

@dvir_a

3 years

You’ve probably seen reports from Israel on low vaccine effectiveness in this wave. Is it because of Delta? Waning immunity? We think the reason is mostly that we got the denominator wrong.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

my suspicion: most of this is CureVac using uridine instead of m1Ψ in the mRNA itsself... you're likely to accidentally hit RIG-I/MDA5 before the ribosome that way & wind up w/translational shutdown via phosphorylation of eIF2α after induction of ISGs...

Carl Zimmer

@carlzimmer

3 years

Ouch. CureVac reports an efficacy of just 47 percent against Covid-19 in a preliminary analysis of their Phase 3 trial. Here’s my @nytimes story

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

1 year

no. SARSCoV2 should *not* be "considered a retrovirus", as it is not one. good lord.

Chris Turnbull

@EnemyInAState

2 years

If anybody is interested in learning more about the reverse transcription of HIV this video explains it: Covid has also been found to reverse transcribe into genes: what it means is Covid should be considered a retrovirus:

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@wanderer_jasnah

2 years

from a mostly-Sinovac country, so important data to have.

Max Roser

@MaxCRoser

2 years

Updated data: The COVID death rate among unvaccinated people is 25-times higher than among vaccinated people who received a booster. This is the latest age-standardized data from Chile. [From this post with @redouad : ]

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

the sheer number of people desperate for BA.2 Omicron, or BA.2 Omicron+whatever to be the Andromeda Strain instead of just the boring, obvious answer of VACCINATION IS GODDAMN KEY is absolutely *infuriating*.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

oh hey EFD finally blocked me. amazed it took this long, honestly.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

Tom. please explain to me, mechanistically, how this is supposed to happen even in theory or stop bloody saying it. "vaccine escape" is not a bloody thing.

Dr. Tom Frieden

@DrTomFrieden

3 years

1) The emergence of future variants that can escape vaccine-induced immunity. Delta may not be the worst variant the virus deals us. Continued uncontrolled spread around the world makes this scenario more likely.

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@wanderer_jasnah

3 years

oh perfect, i've been waiting for exactly this data. basically confirms nicely what we've all been suspecting for the past few weeks.

Devan Sinha

@DevanSinha

3 years

Quite interesting. Figure 6D 👀 Omicron appears to have switched cell entry preference to endosomal fusion (rather than ACE2+TMPRSS2 mediated cell surface fusion like previous variants, incl. the well adapted Delta). Pre-print from Glasgow Uni:

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

hot take: we should be teaching people research skills & critical thinking skills so they *can* do their own research w/o easily falling prey to misinformation/disinformation vendors.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

dear clowns in my menchies demanding that we specifically, somehow, eliminate this virus, while it's still in pandemic phase, try & recall that we have a sterilizing vaccine for polio, have been running an elimination campaign for decades, it's not airborne & we're *almost* done.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

...selection pressure *once in the endemic state*. what causes the shift is the virus going from antigenically novel to us having prior immunity. @dylanhmorris wrote a great article on this that is *highly* worth a read:

Novelty Means Severity: The Key To the Pandemic

Nothing in a pandemic makes sense except in the light of novelty: A guest essay.

www.theinsight.org

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

are you high?!?

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

just saw some in vitro Omicron cell entry data & like. it's like looking down a microscope at a cell culture & seeing a thousand dancing hamsters. fairly convinced we've reached the stage of pandemic where this virus is just openly trolling us.

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@wanderer_jasnah

11 months

it is deeply morbidly hilarious to me that there are a zillion "look the novel β-CoV emerged in same city as a big CoV lab" takes & yet nobody points out the novel β-CoV emerged in the city where the "banned" wildlife trade was quietly allowed, then turned into a hub for it.

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@wanderer_jasnah

3 years

"don't do this, only i am allowed to misinterpret vaccine efficacy data from PHE."

Dr. Deepti Gurdasani

@dgurdasani1

3 years

With all due respect, please don't do this. It's incredibly confusing public messaging when people see different estimates of efficacy each week from data that we just can't infer these from. PHE will analyse the full data & produce robust estimates. We need to be sure about this

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@wanderer_jasnah

2 years

brief break from China protests to highlight: if you asked me what scares me the most right now virologically, it's H5N1. no contest. people need to follow UK's lead & have vaccines for it on the ready. they *WILL* be necessary, & far sooner than some people realize.

ProMED

@ProMED_mail

2 years

PRO/AH/EDR> Avian influenza (219): Asia (Viet Nam) poultry, HPAI H5N1, spread

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@wanderer_jasnah

1 year

genuine question, but is there really any motivation for US virologists to, like, give a fuck at this point? your warnings get ignored, repeatedly, & then when the scenario forecasted happens, the most mendacious midwits blame you for *causing* it.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

still a classic:

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@wanderer_jasnah

1 year

these are uh these are quite the cases to have one of the justices bribed, holy shit:

Chris Murphy 🟧

@ChrisMurphyCT

1 year

It's not like Harlan Crow is some apolitical pal of Thomas. He CONSTANTLY has cases before the court. He funds groups that argue for outcomes that benefit him. One group, CCI, filed 8 briefs before the Court. Thomas sided with Crow in all 8 cases.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

it's just that b/c none of them are novel at an age where they are *likely* to cause disease do we consider them mostly harmless. *this* is the projected final state of #SARSCoV2 . importantly, it'll only happen once we *all* (12+, at least) have immune memory to it. not sooner.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

Show me a picture on your phone that has your energy. Not a selfie.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

like maybe, JUST MAYBE, we could agree to practise due diligence BEFORE giving papers airtime? especially when this can influence vaccine allocation for the world?!? AT LEAST READ THE FUCKING THINGS & THINK ABOUT THEM BEFORE GIVING THEM AIRTIME. IS THAT *REALLY* TOO MUCH TO ASK?

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

well *this* is a deeply irresponsible shit paper. shows escape from NTD nAbs which also put RBDs in the "up" position which might improve infectivity. somehow goes on to claim that loss of serum neutralization is the same as vaccine resistance (it's not). in short, crap.

bioRxiv Microbiology

@biorxiv_micrbio

3 years

The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines #biorxiv_micrbio

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

y'know, it's honestly pretty hilarious having a bunch of iSage-adjacent folks up in my menchies calling me a #COVID19 "minimizer", like, uh, have y'all actually read like any of my tweets? like at all???

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

⚠️ THERMONUCLEAR BAD.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

4 years

also you are confusing primer sets (N1, targeting a sequence in #SARSCoV2 nucleocapsid & N3, targeting a part of the coronavirus replicase that is conserved between all β-CoVs that we have sequences for) w/the genes they target.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

anytime i see grifters talking about "crypto" from now on i'm just going to pretend they actually mean cryptosporidium.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

look i know asking The Daily Fail to know basic EU geography is apparently a bit much, but still, come the fuck on...

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

i am once again watching Western countries snatching defeat from the jaws of victory moments away from the finish line, a point which they are immensely privileged to be at, while in large parts of the world deaths from #COVID19 are at record highs & honestly i feel so defeated.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

⚠️NEXT BIG ONE!

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

just saw the most astoundingly hilarious take: "Jesus wasn't vaccinated!" & it's like. look Jerry unlike Jesus i can't be resurrected 3 days after i die in the ICU from respiratory failure so i fail to see the relevance here.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

look if you're going to tweet alarmist word salad, could you at least be consistent within tweets? (H78Y is in orf3a, *not* S). anyway i checked out the paper cited, it's small magnitude of effects in VeroE6 cells for various orf3a mutations, ***NONE OF WHICH ARE H78Y***.

COVID NEWS NETWORK

@COVIDnewsfast

2 years

According to this study, ORF3A protein is associated with COVID-19s immune evasive capacities, given that this H78Y mutation is on this spike protein, we must monitor closely the impact to vaccines and prior BA 1 infection.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

fuck's sake, i'm absolutely incensed w/the Israeli MoH now. like, they're claiming results that have powerful implications on how a lot of countries might decide vaccine distribution, are known to use dodgy-as-fuck methods & so *need* to release literally all the data they have.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

to anyone that wonders why i'm falling apart lately: how do you not when your home is literally becoming unrecognizable before your very eyes, you can't do anything about it w/o risking jail & the people responsible actively want to rewrite our history on top of that?

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

seeing a lot of comments to the effect of "well EFD didn't *exactly* say #COVID19 is airborne HIV..." (he just QTed someone saying that, heavily implied it & linked to no studies) & like. look, i generally steelman people's arguments on principle but this isn't a debate.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

1 year

i'm at such a loss for words i can't even think of which swearwords to use. one in THREE people??? AIDS?!? do you have *ANY* idea how abjectly horrifying that would look like in society if that were even *REMOTELY* true? this is absolutely insulting to so many people.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

17 days

@ElytraMithra either that or they have discovered local crypto opportunities (cryptosporidium).

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

2 years

if this were true (it's not), then why does "boostering every year endlessly for flu" not "deplete our pool of naive T cells"? come on people, think more.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

the one thing about this that baffles me a bit is the lower lung TCID50s for *Delta*, which is known to cause *greater* lung pathology in the unvaccinated in vivo.

Leo Poon

@world_epidemic

3 years

Omicron replicates much better than Delta in bronchus, but not in lung, explaning why Omicron is so transmissible. Excellent ex vivo studies from Michael Chan @HKU_SPH and John Nicholls in Department of Pathology @hkumed

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

by the time you're 12 you're almost guaranteed to have caught mild HCoV-OC43, HCoV-HKU1, HCoV-229E & HCoV-NL63. by the time you're re-exposed to them, a reinfection is like a vax breakthru: you have immune memory.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah

3 years

amazing, it literally seems like the *entirety* of the ivermectin-as-a-COVID19-therapeutic ""data"" is fraudulent. like, literally *all* of it.

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Jasnah Kholin - 8964 - ACAB

@wanderer_jasnah