Our work made the cover
@ScienceTM
!
In this latest
#ultrasound
🫱🏽🫲🏻
#neurotech
work, we demonstrate functional ultrasound imaging (fUSI) of human brain activity through an acoustically transparent cranial window, opening new doors for non-invasive, high-resolution neuroimaging. 🧵
One of my favorite scientific findings:
Some languages are very information dense and some less so. Some languages are spoken fast and some slow.
And it turns out that people around the world speak at about the same information rate (~39 bps) regardless.
It can be tempting to extrapolate the increasing capabilities of electrode-based motor BCIs and claim they’ll enable superhuman performance in a few years.
This paper is one reason to suggest there is a “speed limit” to consider.
So excited to finally share this work on
@biorxivpreprint
demonstrating transcranial functional ultrasound brain imaging through a transparent skull prosthetic!
I have been dying to share our news and it’s finally here:
@ForestNeurotech
and
@ButterflyNetInc
are teaming up to build the next generation of neurotechnology!
Thrilled to share our latest work out today in
@NeuroCellPress
using functional
#ultrasound
(fUS) neuroimaging to decode movement from single trials in non-human primates 🐒 - a new benchmark for fUS & a precursor to closed-loop
#BCI
.
#tweetprint
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New Ultrasound BCI results are out!
"I remember how impressive it was when this kind of predictive decoding worked with electrodes two decades ago, and it's amazing now to see it work with a much less invasive method like ultrasound," -
@mikhailshapiro
.
"China's brain-computer interface technology is catching up to the US. But it envisions a very different use case: cognitive enhancement."
Interesting perspective from
@emilylmullin
in
@WIRED
This is the most succinct and clearly written primer on whole brain emulation
Includes the various approaches and how they might be combined more effectively
Love this post from
@patrickmineault
!
h/t
@allisondman
Thrilled to share our latest work on
#biorxiv
@biorxivpreprint
using functional ultrasound neuroimaging to decode movement intention from single trials in non-human primates 🐒
Now, my first attempt at a
#tweetprint
! 1/n
Forest Neurotech is hiring!
Three roles on the engineering team (Palo Alto, CA)
- Principal Mechanical Engineer
- Principal Electronics Systems Engineer
- Principal Engineering Program Manager
@ all my Neurotech friends -- please share 😊
Im so thrilled to share
@ForestNeurotech
’s supporters: Eric Schmidt, Griffin Catalyst, the philanthropic organization of Citadel CEO Kenneth C. Griffin, the Riley & Susan Bechtel Foundation, and James Fickel.
Thank you all for making Forest a reality!
The fields of neuroscience and BCI lost one of their best and brightest. We have some big shoulders to stand on.
My thoughts are with Krishna’s family, friends, and all of wonderful scientists he's worked with and trained that I've gotten to know over the years.
🧠Excited to share our latest ultrasound & neurotech paper on
@biorxivpreprint
!
Led by the brilliant
@WhitneySGriggs
, we used functional ultrasound neuroimaging (fUSI) to reveal how the brain orchestrates rapid eye movements.
It's Wednesday, time to read our new issue:
This issue's cover is by Holly Sullivan: a cerebral vascular tree with digital leaves, reflecting sound waves containing information about cognitive states for
@SumnerLN
& coll's paper 👉
Wow, fantastic news!
"While all attention was focused on Neuralink, Paradromics quietly developed a breakthrough device and technology"
Huge congrats to
@Matt_R_Angle
, the entire
@paradromics
team +
@PrimeMoversLab
!
Grad students make ~$24k/yr. Under the new tax plan (that taxes tuition waivers), I would have made <$20k/yr after taxes, below minimum wage. No grad student is in it for the money. Stop taxing students.
#GradTaxWalkout
#SaveGradEd
Are you a talented data scientist? Do you know a talented data scientist? Are either of you interested in neural interfaces / BCI?
💡Come work with us!💡
Really enjoyed presenting a new talk on functional ultrasound neuroimaging as a "second-generation" brain-computer interface / BCI platform at the
@CaltechN
@ChenInstitute
retreat this morning.
Thanks for the photo
@ECriadoHidalgo
!
Imagine if we could use ultrasound to detect changes in tumor cells in real-time.
@mikhailshapiro
is
#ImagingTheFuture
by creating acoustic biomolecules—the first-of-its-kind contrast agent that will allow ultrasound
#tech
to image the functions of cells deep in the body
I had so much fun revisiting the history of neurotech. Thanks to all of the thoughtful discussion from all attendees. Thanks
@foresightinst
for hosting!
If you’ve ever been curious about how the past, present, and future of neurotechnology come together, have a listen.
Explore the evolution of Neurotech for mental health with Sumner Norman – from outdated chemical imbalance theories to specific circuits/systems. Ultrasonic brain-machine interfaces offer promise, aiming to revolutionize treatment.
@SumnerLN
(1/N) Have you ever wondered how your
#brain
represents the meaning of language? Despite the centrality of language to the human experience, we know very little about how neurons represent words. Thanks to new single unit recordings in humans, we have some answers! A
#tweetprint
:
Neurotech day 1 at Edge Esmeralda was a blast! Thanks to everyone who joined the neuro/FRO crew.
It was wonderful meeting many of you and I hope I have the chance to catch up with those I missed (come say hi today)
Thanks again
@ProtoResearch
and
@foresightinst
for hosting
@jacobrintamaki
Zoom masks over and delays super important visual cues.
The mismatch of expected nonverbal cues and the low-res/latent zoom screen is super fatiguing.
Okay, sure, I’m biased. But this was an absolute masterclass in presenting an exciting but unfamiliar new technology (functional ultrasound) to a field with 100+ years of using electricity.
#BCI2023
Congrats to (recent
@CaltechN
PhD grad)
@WhitneySGriggs
!
Laws governing BCI are taking shape in Washington DC starting *tomorrow*. It’s critical to build an environment that protects users/national interests *and* fosters innovation.
Do you have opinions about BCI development & regulation? Contribute here!
Many were blown away by Gallant lab (Nishimoto 2011), MindEye, etc. Those used fMRI to reconstruct vision from human participants.
It's *super* cool to see this ("reverse translational"?) work in a different modality/mice.
+1 in the "visual reconstruction works" bucket.
🚀 Excited to share the first preprint from my postdoc in the labs of
@ClopathLab
and Troy Margrie at
@SWC_Neuro
! We've reconstructed movies from mouse visual cortex activity. 📽️✨
#Neuroscience
#AI
1/6
@JamieReilly_cog
There's something disingenuous about the narrative that you have to design an algorithm for Mark Zuckerberg if you work in industry. There are groups doing amazing things geared toward public good if that’s important to someone making a postdoc/industry decision.
Loving the "good vibrations" heading 😂 Thanks for sharing our work with the world,
@emilylmullin
& co at
@WIRED
! 🔊🔊🔊
"Forest Neurotech in Los Angeles also launched this year to [...] miniaturize ultrasound in a neural implant."
#BCI
#Neurotech
The brain's "readiness potential" appears ~1/2 second before the conscious experience of the intention to move (Libet). This result is often used to challenge concepts of free will & consciousness.
Now we know subconscious brain activity emerges long before that...
Kicking off the week strong!
Yesterday, our team
@ForestNeurotech
had the incredible opportunity to join with partners
@ButterflyNetInc
at the iconic
@NYSE
. 🌲🦋
Groundbreaking neurotech in progress🧠🔊
🌲 We’re hiring at Forest Neurotech! 🧠
Principal Electrical Engineer (Palo Alto, CA)
Join us to create next generation neurotech. We’re looking for a Principal Electrical Engineer to accelerate our ultrasound implant’s electronic systems efforts.
Is your zone of genius delivering scientific results in high-quality, production-grade software?
If so,
@ForestNeurotech
is hiring Software Engineers in Los Angeles and Palo Alto!
Forest Neurotech is hiring!
If you have experience building/using **ML Infrastructure** for large (PetaByte) datasets, consider applying!
Please retweet 🙏🏽
Link in replies
So proud to have been a part of the (insanely talented)
@AEStudioLA
team that made this happen.
Go check out the GitHub. Build on it. Beat our method! Share. Repeat :)
From imagined writing to reality! In 2021, Willet et al. revolutionized
#BCI
, enabling individuals with paralysis to write just by thinking it.
We built on this amazing result to improve efficiency & performance. We’re thrilled to share our code
Really looking forward to this!
Many have been following the updates from a certain neurotech company lately. But we're just seeing the first generation of commercial
#BCI
. What's next?
On December 13th, we'll be joined by Sumner Norman for a presentation to Foresight's Neurotech Group! Make sure to subscribe to our YouTube channel, so you don't miss the recording:
Just received good news about a close family member recovering from a serious medical condition.
It’s incredible what good relationships and good health do for our head space.
Feeling more optimistic, productive, and generally positive than I have in a long time (even with
Can we image intracellular calcium with ultrasound?
Yes, w/ultrasonic reporters of calcium - URoCs!
Congrats to
@ZhiyangJin
and co-authors on creating the first genetically encoded acoustic biosensors of this universal cell signal based on
#gasvesicles
.
We pack hundreds of people onto pressurized aluminum tubes and shoot them halfway around the globe at incredibly low cost. All day, every day, for years, with a a near-perfect safety record.
We absolutely build big things.
We get used to the magic so quickly.
Neuropixels ✅
Human recording ✅
Single neuron precision speech encoding ✅
Yep, it’s Eddie Chang and colleagues
@UCSF
setting the bar (again). Congrats all involved!
Researchers
@UCSF
, led by neurosurgeon Edward Chang, MD, have used
#Neuropixels
probes to record activity from hundreds of individual neurons while participants listened to speech. Out today in
@Nature
, this study gives us a view into how the brain analyzes the sounds in words.
“Neuralink says it plans to perform 11 surgeries in 2024, 27 in 2025 and 79 in 2026. Then things really ramp up, going from 499 surgeries in 2027 to 22,204 by 2030”
The next generation of BCIs has arrived! We are using ultrasound to detect and decode intention in real time/closed loop.
Check out the tweetprint (and also the pre-print) from
@WhitneySGriggs
!
Thrilled to share our latest work on
@biorxivpreprint
demonstrating the first real-time closed-loop ultrasonic brain-machine interface (
#BMI
)! 🔊🧠-->🎮🖥️
Paper link -
A
#tweetprint
. 🧵1/n
I had a great time discussing cutting-edge neurotech on Neurotech Pub with
@Matt_R_Angle
: “Where There’s Blood, There’s Signal”
We covered mentorship, optics/acoustics, BCI,
@Convergent_FROs
, and much more!
Was a blast recording a podcast on our
@NeuroCellPress
paper on brain-machine interfaces and functional ultrasound neuroimaging with
@sethbannon
!
Full episode here:
Subscribe:
Thanks
@IEEESpectrum
for covering our work at Forest! While “BCI developers Neuralink, Paradromics, and Synchron all reached important milestones. […] A recently announced research collaboration is developing a BCI that uses a radically different medium: ultrasound.”
"Patients had Precision’s system on their brains for 15 minutes. Two patients were woken up so [Precision] could capture their brain activity as they spoke.
Precision Neuroscience conducts early human feasibility experiments.
When it comes to Neurotech/BCI...
Restoration vs. Augmentation is a false dichotomy.
These lie on a spectrum, similar to the disorders, injuries, and everyday shortcomings that humans experience on a daily basis.
“Our BCI decoded speech at 62 words per minute, 3.4 times faster than the prior record for any kind of BCI and begins to approach the speed of natural conversation (160 words per minute)”
9.1% word error rate on 50 word vocabulary and a 23.8% on 125,000 word vocabulary
Wow 🤯
“In the early days, Arbaugh had to learn how to tune Neuralink’s software to his brain patterns and get the gist of turning thoughts into action. As the weeks went by, the process became second nature. Arbaugh could carry on a conversation with someone while playing chess at the
Last couple of months to submit to this BCI competition! (h/t
@SergeyStavisky
for catching the dates 🙃)
"The goal of this competition is to foster the development of new and improved algorithms for decoding speech from the brain."
"We plan to organize a workshop at ICML 2024
This was such a pleasure to present, especially thanks to all of the thoughtful discussion from all attendees. Thanks
@foresightinst
for hosting!
If you’ve ever been curious what the future of neurotechnology holds, have a listen. Reach out.
What does the future of BCIs hold? Our Neurotech group was pleased to welcome Sumner Norman
@SumnerLN
to explore the groundbreaking advances that have led to the development of commercial BCIs, and what we can expect next. Give it a watch!
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For the past decade, our team at Meta Reality Labs (previously CTRL-labs) has been dedicated to developing a neuromotor interface.
Our goal is to address the Human Computer Interaction challenge of providing effortless, intuitive, and efficient input to computers.
When the results are both scientifically and visually gorgeous 👌
Ultrasound for neuro and for Alzheimer’s specifically is making leaps and bounds.
Congrats
@SongLabUIUC
!
Glad to share that our collaborative work with
@LlanoLaboratory
on super-resolution ultrasound for imaging microvascular impairment in Alzheimer's disease mouse models has been published on
#JNeurosci
@SfNJournals
. We've also made the paper open access:
This report is the months-long culmination of some of the brightest young leaders in the longevity field coming together to prioritize and detail the field’s top bottlenecks:
“Elon got us a lot of publicity and awareness. That’s great for this space,” Gerhardt said, adding, “He just has to come to terms with the fact that he’s not No.1. I’m sure he’ll manage it. He’s already got two great companies out there.”
🔥🔥🔥
"Sumner Norman – a biological engineer at the California Institute of Technology who was not involved in the two studies – tells Physics World that these advances are “a tour de force in technical and clinical excellence”."
It's true, they are. 😊
If you’re joining the
@neuralink
story now or could use a refresher, the PRIME study progress update has a pretty good overview of everything Neuralink has been up to.
It also gives a sense of the multi-faceted, deeply vertical nature of bringing a neurological implant to first
#Optogenetic
therapy in humans!
"goggles detect changes in light intensity and project light pulses onto the retina in real time to activate optogenetically transduced retinal ganglion cells."
🤯 out today in
@NatureMedicine
#neuroscience
#vision
This is one of the most exciting opportunities in
#neurotech
right now.
It's equal parts wildly ambitious and carefully grounded.
Check it out. Be a part of the future of precision neurotech.
🚨Excited to share that our programme thesis is live!🚨
We lay out a vision for ***precision neurotech*** capable of tackling some of the most complex brain disorders at the circuit level. We believe this is possible by leveraging advances in bio- & hardware-engineering🧠🧬💻
@DrDavidBrandman
and I started the UCD Neuroprosthetics Lab 2 years ago... and today our team led by
@NS_Card
&
@Maitreyee_W
won the 2023 BCI Award!
0 to recognized as some of the best work in the field 🥲
Left: me getting keys to our empty lab last year.
Right: just now🙌🎉
“[The Link] has helped me reconnect with the world, my friends, and my family. It's given me the ability to do things on my own again without needing my family at all hours of the day and night.”
— Noland Arbaugh, PRIME Study participant
#Neurotech
💪🏽
🚨Very excited to share my ARIA opportunity space!🚨
Brain disorders are a huge challenge to society and we need a new suite of tools to precisely interface with the human brain at scale.
🧠I'd love to hear from neuroscientists, engineers, clinicians etc working in this space!🧠
We'll dive into BCI and Neurotechnology at this year's
@Abundance360
summit.
Jordan Amadio, MD, Senior Neurosurgeon at
@neuralink
, and
@SumnerLN
, Founder of Forest Neurotech, are joining me for a mindblowing convo.
What questions do you have for them?
#abundancesummit2024
Friday I talked to Dr. Sumner L Norman, the CEO of
@ForestNeurotech
. We talked about building devices that either read from the brain or send information to the brain. How real is this? How much of it is science versus science fiction?
Listen here:
BCI might one day help allow humans to retrieve and store information at the speed of thought. It might also allow tech giants to monitor those thoughts. How can we achieve one without the other?
#SXSW
#SXSW2022
Just a reminder that Williams & Cooper implanted 302 depth and 249 subdural electrodes
... in humans
... in 1963!
The tech at
@neuralink
,
@paradromics
, others is, without a doubt, next level. But let's not forget just how amazing these early feats of
#neurotech
really were.
Ever wondered how Neurotech/BCI can contribute to AI alignment?
We hosted a workshop earlier this year to explore how neurotechnology could help shape the future of
#AI
.
Check it out here:
#Neurotech
challenge from
@neuralink
:
One out of raw Neuralink data from non-human primate motor cortex. Can you perform lossless 200x (or better) compression ?
h/t
@sabrinasngh
Hero scientists invent method to make cold brew coffee in 3 minutes instead of 24 hours, and also invent something called "cold espresso" which I simply must have right now:
No Moonshots With Paper Planes: Alzheimer’s Trials Need Neurotech
"Setting a new gold standard in human research will require ongoing and endless scientific and technical excellence from all new entrants"
Link below
Our work made the cover
@ScienceTM
!
In this latest
#ultrasound
🫱🏽🫲🏻
#neurotech
work, we demonstrate functional ultrasound imaging (fUSI) of human brain activity through an acoustically transparent cranial window, opening new doors for non-invasive, high-resolution neuroimaging. 🧵
A paper from my PhD is officially out today at
@NatureNeuro
where
@SumnerLN
and I demonstrate a closed-loop ultrasound-based brain-machine interface (BMI)!!
Link to paper -
A
#tweetprint
. 🧵1/12