#eNeuro
: When
@UCLA
scientists transferred RNA from
#brain
cells of trained snails to untrained snails, the animals behaved as if they remembered the trained snails' experiences.
@dglanzman
#JNeurosci
: Chari et al.
@UCLANeurology
designed a novel head-fixed behavioral assay that can be used to investigate behavioral responses to social touch and the underlying brain mechanisms in rodent models of neurodevelopmental conditions like ASD.
#eNeuro
Novel Tools and Methods | Characterization of a Knock-In Mouse Line Expressing a Fusion Protein of κ Opioid Receptor Conjugated with tdTomato: 3-Dimensional Brain Imaging via CLARITY
Time-sensitive neurons in the supramarginal gyrus fatigue & skew our subjective perception of time, according to new research from
@HayashiMJ
@BerkeleyPsych
in
#JNeurosci
.
How the brain creates the experience of time:
#Dog
brain structure varies across breeds and is correlated with specific behaviors, according to new research from
@LabHecht
published in
#JNeurosci
.
How humans have shaped the brains of their best friends:
Male mice more susceptible to stress can pass down their behaviors to offspring via changes in their sperm’s genetic code, according to new
#JNeurosci
research from
@ANeurogirl
,
@walkerdm79
,
@EricJNestler
et al.
"A rat is not a little human, a mouse is not a little rat, and flies are not cheap mice.”
In the latest
#eNeuro
Opinion article,
@L_Genzel
discusses factors in rodent studies that will influence whether memory leads to a certain behavior.
"Another thing I wish I'd known when I started out in the field is just what a huge role there is of just dumb luck — in life in general, but science in particular"
@Nancy_Kanwisher
reflects on how the field has progressed during her career in
#JNeurosci
:
#eNeuro
: AAVs are a widely used tool in neuroscience allowing researchers to label, trace, and/or manipulate neuronal populations.
@jjb930
,
@ArruCarval_lab
, et al. report the need to carefully design & interpret data involving Cre-dependent AAV infection.
#JNeurosci
:
@graham_baum
et al used
@HumanConnectome
data to characterize rate & timing of myelin development. They found evidence for prolonged myelin development into the 30's, reflecting ongoing plasticity for learning & complex cognitive functioning
Adult-born neurons keep growing & contributing to brain flexibility long after neurogenesis declines, according to new
#JNeurosci
research in rats from
@DMCBrainHealth
@UBCPsych
.
How neurons created via neurogenesis differ from infancy-born counterparts:
Forget what you saw: a brain region detects when you are about to think of an unwanted memory and alerts other regions to suppress it, according to research recently published in # JNeurosci from
@MaityWinky
,
@Memory_Control
et al
@mrccbu
@SouthwestUni
#eNeuro
:
@WJDroogers
et al. introduce CAKE, a method for achieving double protein labeling using gene editing in neurons, making it possible to determine localization, interaction & dynamics of endogenous neuronal proteins w/ fluorescence microscopy
The brains of musicians have stronger structural and functional connections compared to those of non-musicians, regardless of innate pitch ability, according to new
#JNeurosci
research from
@simonleipold
, Klein & Jäncke
@UZH_en
.
NEW:
#eNeuro
has published a special collection of commentaries written by leading neuroscientists in response to
@In_Silico_Film
, a documentary chronicling Henry Markham's attempt to develop a computer model of the brain.
#InSilico
Browse the collection:
#eNeuro
:
@Michelle_Jin1
et al
@NIDAnews
developed SMART, an open-source extension of the Wholebrain platform, incorporating user-flexibility w/ existing registration & automated cell counting methods to streamline large scale IEG mapping projects in mice.
#eNeuro
:
@MindfulRat
et al. challenge the assumption that enhanced rodent lab housing increases trait variability & show that environmental enrichment can improve the current “gold standard” control housing condition without compromising data integrity.
Celebrating
#LeslieUngerleider
(1946-2020): In this tribute to her life & prolific career,
@ShrutiJapee
&
@jesstaubert
curated several of Dr. Ungerleider's outstanding
#JNeurosci
papers to illustrate the giant impact she had on the field of neuroscience.
Brainy Zoom backgrounds for your next meeting:
@SfNTweets
presents a collection of 10 neuroscience-themed backgrounds from recent
#JNeurosci
&
#eNeuro
research, available for download & use in your upcoming virtual gatherings.
See the full collection:
Rubbing the skin activates an anti-itch neural pathway & can reduce the urge to scratch an itch, according to new
#JNeurosci
research in mice from
@umiamimedicine
.
How stroking skin activates touch receptors & recruits spinal cord neurons for itch relief:
#JNeurosci
:
@CandlerPaige
@UTDPainLab
et al found CGRP promotes acute & chronic pain in female rodents but little effect on male rodents. This works shows that CGRP targeted therapeutics, already used to treat chronic migraine, could treat pain in women.
#JNeurosci
:
@danilobenette
@rafaelruggiero
et al.
@usponline
investigated neural activities during controllable or uncontrollable stress & identified a distinct pattern of hippocampal-prefrontal cortical activity that predict resistance to future stressors
#eNeuro
: Using a new tool to quantify facial expressions in freely moving mice,
@MoeneDr
and Larsson
@liu_universitet
captured different profiles in response to aversive and pleasurable gustatory and somatosensory stimuli.
This watercolor, inspired by the drawings of Ramón y Cajal, shows an oligodendrocyte ensheathing two axons. Drawing by
@danielbelchi
. For more information, see the article by Sanz-Rodriguez et al. in this week's issue of
#JNeurosci
#eNeuro
: Focusing on specific brain regions when studying addiction simplifies research but may omit important insights.
@KimbroughNeuro
et al. show that the entire mouse brain reorganizes during withdrawal, which may hinder communication between regions.
New Dual Perspectives in this week's issue of
#JNeurosci
explore & debate the evidence for hippocampal neurogenesis in adult humans.
Moreno-Jiménez, Terreros-Roncal, Flor-García et al.:
Sorrells, Paredes et al.:
Your brain pays attention to unfamiliar voices during sleep, according to research in
#JNeurosci
from
@mo_s_ameen
, Heib,
@christine_blume
&
@ManuelSchabus
. The ability allows the brain to balance sleep with responding to environmental cues.
Alcohol alters synchronized brain activity associated with anxiety & fear in the amygdala of mice, but differently for male and female mice, according to new research in
#eNeuro
from DiLeo,
@jmaglab
, et al.
@TuftsMedSchool
.
New in
#JNeurosci
:
@MarcusWeera
@The_Gilp
et al.
@LSUHealthNO
find that inhibiting LH-targeting CeA CRF neurons in stress-avoidant rats prevents stress-driven increases in anxiety-like behavior & alcohol self-administration.
#JNeurosciAnnualSpotlight
2020 |
@emilytcowan
,
@LilaDavachi
et al. used fMRI in humans to conclude that the oscillatory pattern of brain activity known as sleep spindles might participate in the restructuring of memory traces during memory consolidation.
#HistoryOfNeuroscience
Vol. 11 is now available! Read accounts of the scientific lives that contributed to the field, written by those who lived them.
Tales of brilliance, fantasy, risk, triumph & camaraderie; stories of choice, opportunity & discovery:
This image provides a sagittal view of white matter fiber tracts in the human brain obtained using Diffusion Spectral Imaging. For more information about the
@NIH
#BRAIN
Initiative, see the article by
@NINDSdirector
and colleagues in this week's
#JNeurosci
#eNeuro
Open Source Tools & Methods | Krynitsky et al. present the RAT, an open-source machine vision camera & real-time control system for tracking mice based around the
@openmvcam
camera.
#RAT4mice
A cheap, simple & flexible device for tracking rodents:
#eNeuro
: Chen et al.
@HopkinsMedicine
measured receptor mobility in the mouse brain, finding there are different fractions of more and less mobile receptors within individual synapses and that this ratio of receptors can be modulated with stress hormones.
A new
#eNeuro
study from
@TheNeuro_MNI
@bic_mni
reports that area 8A in the posterior middle frontal gyrus performs the specific cognitive control process of higher order attentional selection between competing visual environmental stimuli.
Read more:
After a traumatic event, people with decreased activity in the hippocampus experience worse PTSD symptoms, according to new research in
#JNeurosci
from
@busra_to
,
@vpmurty
et al.
@Temple_Psych
"We hope this collection will inspire you with how much progress has been made and how much promise there is to make additional advances in understanding neurons, brains, and behavior in the next 50 years."
@MarinaP63
’s
#50YearsOfNeuroscience
Editorial:
#JNeurosci
:
@JA_Balouek
@cate_cholamine
et al.
@PrincetonNeuro
found nucleus accumbens neurons initially sensitive to early-life stress remain hypersensitive to stress throughout life in mice. Inhibiting neurons during stress ameliorated hypersensitivity.
In this Editorial, Editor-in-Chief Sabine Kastner introduces the new open peer review model for
#JNeurosci
. Learn how peer review models have evolved and why sharing anonymous reviewer feedback on published papers can be valuable.
New quantitative approaches to volumetric fluorescence labeling will enable rigorous analysis of how synapse distributions change across different brain conditions, including development, learning, and disease.
Novel Tools & Methods in
#eNeuro
:
New
#JNeurosci
research from
@CosmicOmBrain
et al. provides a new role of the medial intercalated cells (mICCs), the gatekeeper of amygdala output, in modulating contextual fear in a dynamic and sex-dependent manner.
#JNeurosci
: Using high-resolution 3D mapping methods in adult mice, Son et al.
@yongsookimlab
@penn_state
found Oxytocin connections with 9 functional brain circuits controlling cognition, brain state, & somatic visceral response.
#eNeuro
: AAVs are a widely used tool in neuroscience allowing researchers to label, trace, and/or manipulate neuronal populations.
@jjb930
,
@ArruCarval_lab
, et al. report the need to carefully design & interpret data involving Cre-dependent AAV infection.
New in
#JNeurosci
: following up on the discovery that rats favor social reward over drug rewards, the lab of
@yavinshaham
@NIDAnews
@NIH
finds sex differences in social behavior: males prefer opposite- over same-sex interactions.
#JNeurosci
: Gallo,
@pedrobek
,
@Memory_Control
et al. found dopamine release in the medial prefrontal cortex of rats was essential to causing active forgetting of competing memories. Inhibition of D1 receptors impaired forgetting, & activation increased it.
Contrary to previous theories, fear & anxiety reflect shared neural building blocks, according to new
#JNeurosci
research from
@ajshackman
@umdnacs
that highlights the need to reevaluate the existing models guiding anxiety research.
Read more:
#eNeuro
from
@PozzoMillerLab
@UABSOM
: Synaptic plasticity in cortico-striatal pathways is hemisphere-dependent, providing a novel mechanistic insight into how cortical neurons distinctly modulate ipsilateral & contralateral subcortical regions.
Read more:
#JNeurosci
:
@russo_eleon
et al. developed a statistical approach to investigate dynamics of the prefrontal cortex during suppression of conditioned behaviors, revealing fundamental operational dynamics of the prefrontal cortex for behavioral flexibility.
#eNeuro
Open Source Tools & Methods |
@JudeFrie
@JakeW_Underhill
@DrJKhokhar
created OpenVape, an affordable, open-source apparatus for use in behavioral experiments to expose rodents to e-cigarette nicotine vapor.
Read more:
New
#JNeurosci
research from
@_zhaoyufei
,
@AChanales
&
@KuhlLab
demonstrates that in order to remember similar events, the brain exaggerates the difference between them, resulting in divergent brain activity patterns but better memory performance.
Researchers
@WSUPullman
developed a novel rat model for
#cannabis
that involves response-contingent delivery of whole-plant extracts using e-vape tech, which will be valuable for studying neural mechanisms that lead to cannabis use & misuse.
#JNeurosci
:
New
#JNeurosci
work from
@DMCBrainHealth
@UBCPsych
shows that the dorsal, prelimbic medial prefrontal cortex aids in both active avoidance of aversive events & withholding of responses to obtain rewards.
Mechanisms underlying avoidance & reward-seeking:
#JNeurosci
: The brain draws on past experiences to make predictions on the future. How do these predictions influence memory for new experiences? Research from
@brynnesherman
et al suggest an adaptive role for prediction in regulating when we form memories
#JNeurosci
: Unprecedented view of changes in brain activity created by electrical stimulation could inform individualized stimulation protocols for neuropsychiatric disorders
How is taste info encoded?
#JNeurosci
research reconstructing the synaptic circuitry of taste buds from
@courtthewilson
et al
@taste_and_smell
@CUAnschutz
, find that taste cannot entirely be carried along nerve fibers dedicated to single taste qualities.
Mouse models of neurodevelopmental disorders possess unique, sex-specific metabolic dysfunctions, according to a new study in
#eNeuro
from
@menzies_caitlin
,
@BaptisteLacost3
et al.
A new
#JNeurosci
study from
@theCousinLab
reveals that an SV2A mutant identified in human
#epilepsy
loses the ability to control both expression & trafficking of synaptotagmin-1, which is essential for accurate neurotransmitter release.
Read more:
#JNeurosci
: Gallo,
@pedrobek
,
@Memory_Control
et al. found dopamine release in the medial prefrontal cortex of rats was essential to causing active forgetting of competing memories. Inhibition of D1 receptors impaired forgetting, & activation increased it.
#JNeurosci
:
@leake_jess
,
@ZinnRaphael
et al. show that detail-poor fear memories formed after insufficient learning time are encoded by fewer neurons that are reactivated in both dangerous & safe contexts in mice, leading to fear in irrelevant situations.
A
#JNeurosci
study in mice from
@AsafKeller
is first to show that
#fentanyl
exposure in the womb results in behavioral, circuitry & synaptic effects that last at least to adolescence, and that exposure has lasting effects on synapses in different areas.
Research in
#JNeurosci
from
@prolactingrl
@prolactinguy
et al. show prolactin, known for its female-specific role in lactation, has a role in the male brain to promote parental care. Father mice w/o prolactin fail to show normal retrieval behavior of pups.
#JNeurosci
: Using a combination of behavioral experiments & computational modeling,
@AlkisMH
et al. show that the brain uses movement errors to directly update controllers that drive motor output, countering predominant theories of sensorimotor adaptation.
#JNeurosci
: New research in male rats suggests two pathways in the
#brain
converging at the amygdala regulate the
#anxiety
and
#depression
that often accompanies chronic pain:
#JNeurosci
:
@ntlichten
@KateWassum
et al. find a critical circuit between basolateral amygdala & medial OFC affecting decisions & reward evaluation, which may inform new research on substance use disorders & mental illnesses marked by poor decision making.
#JNeurosci
: Li,
@neurojess29
et al.
@cwru
@CWRUSOM
report in mice that a novel glutamatergic input from hypothalamic supramammillary nucleus selectively innervates interneurons over PNs to predominantly suppress PN activity in area CA3 in the hippocampus.
Multitasking performance stems from the speed of information exchange between the putamen & cortical regions of the brain, according to new research from
@QldBrainInst
@UQPsych
in
#eNeuro
.
The missing piece of the brain's multitasking network:
New
#JNeurosci
research from
@PauSalamone
,
@AgustinaLegaz
et al. examines whether and how emotions are primed by interoceptive states and the impact of interoceptive coding over negative emotions and across neurodegenerative conditions.