Harry Spoelstra @HarrySpoelstra Twitter profile

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Harry Spoelstra

@HarrySpoelstra

10 months

You won't believe this. Yesterday, during my private consultations, my German Shepherd reacted strangely and evasive towards one single patient with a sniff, not his normal behaviour, actually the opposite.....today, that patient notified me that she just tested RAT C-19

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Harry Spoelstra

@HarrySpoelstra

3 months

BREAKING: Tour de France 2024 @LeTour instigates full C19 protocol today, face masks with visitor/press restrictions.....about time! 👏👍

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Harry Spoelstra

@HarrySpoelstra

1 year

Mysterious Pediatric hepatitis of unknown etiology, ➡️We were right, it was COVID-19! T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19

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Harry Spoelstra

@HarrySpoelstra

2 months

A clinical case this late afternoon: Urgent ER referral, 26y old, very sportive and healthy guy, no comorbidities, vaccinated, but had his 3rd mild C19 2 months ago.... suddenly collapsed on his bike, He broke his wrist, had some cuts and bruises and wrecked his bike. Oh,

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Harry Spoelstra

@HarrySpoelstra

1 year

Bad news for many paediatricians and fake-experts: ➡️CHILDREN represent a major transmission vector, yesterday, today and tomorrow! "Children infected from diverse pediatric facilities can be a major source of widespread household transmission with the potential to facilitate

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Harry Spoelstra

@HarrySpoelstra

1 year

A sad anecdotal message from a colleague: 31y unvaccinated woman succumbed recently to a sudden death, probably cardiac arrhythmia event, 3-4 months after her 3rd Covid19 infection, complaining of some clear LongCovid symptoms but dismissed by their GP, leaving her husband and 2

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Harry Spoelstra

@HarrySpoelstra

2 months

⁉️Does everybody understand 👇 "Even those who RECOVERED FULLY from COVID-19 still showed persistent changes to their T cell activity in numerous organs compared to pre- pandemic controls, in some cases two and a half years after they first contracted the virus." 😱 Connect

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Harry Spoelstra

@HarrySpoelstra

1 year

EXCELLENT ARTICLE on @zalaly , a #mustread ❗️❗️“Long COVID is leaving a legacy of chronic diseases,” Al-Aly said. “Health systems and governments need to be prepared for the long-lasting consequences for patients, health systems, life expectancy and economic productivity.

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Harry Spoelstra

@HarrySpoelstra

10 months

Let's be very clear, he hasn't been trained to do this... this was a spontaneous reaction, making it indeed more special....😳 #MyDogDuke

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Harry Spoelstra

@HarrySpoelstra

1 year

Thinking out loud: BA.2.86 may be the most immune evasive variant till now, but in becoming this, it may also have lost some of its intrinsic transmissibility(RO ↓) resulting in a less explosive spread(=mutational trade-offs made), If true, this may well mean that the world will

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Harry Spoelstra

@HarrySpoelstra

9 months

No, no, no, I'll never accept this "new normal" as a physician, people dying, their health stricken or mortgaged for years to come....by the thousands every day, no....this is simply admitting failure to contain SarsCoV2, a sign of cowardness to fight it, and we have the means to

Bob Wachter

@Bob_Wachter

9 months

Excellent @TIME piece by @Jamie_Ducharme on how to think about the current #Covid surge. Yes, it's probably our "new normal," with upticks a few times a year, including each winter. Quotes by @ashishkjha , @dr_kkjetelina , @ahandvanish , @PeterHotez , & me.

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Harry Spoelstra

@HarrySpoelstra

1 year

And again..... the important #Covid19 transmission role of schools and Children, with very BAD news for the anti-mask brigade: ➡️Molecular detection of airborne and human #SARSCoV2 indicated sustained transmission in schools. ➡️Mask mandates were associated with greater

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Harry Spoelstra

@HarrySpoelstra

1 year

Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in COVID-19 patients (Omicron study) ➡️Middle ear infections due to viral persistence, some long lasting, as a possible symptom in C19 and during post-C19 period(Possible LongCovid?)

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Harry Spoelstra

@HarrySpoelstra

2 years

🔥"Our study demonstrated for the first time the persistence of LV myocardial deformation abnormalities in previously healthy children with an asymptomatic or mildly symptomatic (WHO stages 0- 1) COVID-19 course after an average follow-up of 148 ± 68 days"

Mid- and Long-Term Atrio-Ventricular Functional Changes in Children after Recovery from COVID-19

Background: Although most children may experience mild to moderate symptoms and do not require hospitalization, there are little data on cardiac involvement in COVID-19. However, cardiac involvement...

www.mdpi.com

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Harry Spoelstra

@HarrySpoelstra

2 months

A REMINDER! Science is confirming that @fitterhappierAJ was right from day ONE! H/T @DavidJoffe64

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Harry Spoelstra

@HarrySpoelstra

1 year

Here's your "bomb" for today! #Reinfections “SARS-CoV-2 reinfection: Adding insult to dysfunctional endothelium in patients with atherosclerotic cardiovascular disease” ➡️“Both the first infection and reinfection with SARS-CoV-2 increase cardiac event risk, particularly in

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Harry Spoelstra

@HarrySpoelstra

1 year

As I previously have called your attention for, “OUTDOOR AIR INFECTIONS ARE POSSIBLE, more science: Study: “Analysis of a super-transmission of SARS-CoV-2 omicron variant BA.5.2 in the outdoor night market” ➡️“Aerosols with BA.5.2 strain released by patients could suspend in

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Harry Spoelstra

@HarrySpoelstra

1 year

The good news for today!! Data have shown that Novavax's COVID booster induces broadly neutralizing responses against XBB subvariants, including EG.5.1 and XBB.1.16.6

Novavax's Updated Protein-based XBB COVID Vaccine Induced Neutralizing Responses Against Emerging...

/PRNewswire/ -- Novavax, Inc. (Nasdaq: NVAX), a global company advancing protein-based vaccines with its novel Matrix-M™ adjuvant, today announced that its...

www.prnewswire.com

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Harry Spoelstra

@HarrySpoelstra

1 year

Infection prevention should be a cornerstone in Medicine, these authors agree and advocate that #Healthcare still need #Masks 🎯 This C19 Pandemic isn't over yet!

Experts say it's not yet time to take off masks in the health care setting

A new commentary from infectious disease experts at George Washington University School of Medicine and the National Institutes of Health (NIH) says for patient safety, masking should continue in...

medicalxpress.com

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Harry Spoelstra

@HarrySpoelstra

11 months

Well, well, paediatrians, there goes your immunity debt BS....😬 @fitterhappierAJ was right!

AJ Leonardi, MBBS, PhD

@fitterhappierAJ

11 months

Over three years ago I claimed covid was harming parts of the immune system responsible for viral immunity I was pilloried for being a junior with a hypothesis- a cardinal sin Now it is published covid infection raises risk for RSV in kids

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Harry Spoelstra

@HarrySpoelstra

1 year

Sweden "Herd-Community" waking up to a new hard post-covid19 reality 😬

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Harry Spoelstra

@HarrySpoelstra

8 months

❗Sad afternoon, We lost a non-smoking, healthy, sportive, 34y male patient. He had a zero medical history, only probably suffered a recent nearly asymptomatic RCA MI(GP), awaiting cardiological check-up. This afternoon he was urgently admitted due to a sudden arrythmia onset

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Harry Spoelstra

@HarrySpoelstra

1 year

CARDIOVASCULAR COMPLICATIONS OF COVID-19 (Mayo Clinics, 2023) Key Points ➡️"Cardiovascular complications are a common manifestation of acute and post-acute COVID-19 infection/LongCovid" ➡️"Symptoms and signs may include chest pain, palpitations, impaired activity intolerance,

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Harry Spoelstra

@HarrySpoelstra

1 year

Interesting review, lets recap because of its BIG IMPORTANCE and again C19 isn't a flu and can kill some of you even months after your initial C19, even if you didn't need Hospitalisation( so-called "mild")!! ➡️The review includes 6 studies involving over 12 million patients,

Emmanuel

@ejustin46

1 year

Emerging Links Between COVID-19 and Cardiovascular & Cerebrovascular Thromboembolic Events: A Systematic Review

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Harry Spoelstra

@HarrySpoelstra

1 year

Not official, but receiving news that new C19 cases are rising further in #Belgium with yesterday alone >200! (Last week 7day average =126) Also mention of rising new hospital admissions while listening around in my personal and professional circle and also hearing of more people

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Harry Spoelstra

@HarrySpoelstra

1 year

With every day in this ongoing Pandemic what astounds me the most is the general total lack in understanding what Longcovid could mean for individuals, some even being professional athletes or HCW’s. Sometimes I get the feeling that this is today’s new taboo! ➡️The possible

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Harry Spoelstra

@HarrySpoelstra

1 year

Comparative study showed that children faced a 78% higher risk of new-onset conditions after they had COVID-19 (0-14y/ early Pandemic period) ➡️Study provides evidence of the increased risk of new conditions after #COVID19 disease in children. - mental health issues(aHR 1.8, 95%

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Harry Spoelstra

@HarrySpoelstra

1 year

Tonsils are major sites of persistence of SARS-CoV-2 in children ❗Hallo, your attention, Children/SarsCoV2/Tonsils ➡️"Study shows that #SARSCoV2 of different lineages can infect tonsils and adenoids in one quarter of children undergoing tonsillectomy" ➡️"Showing that tonsils

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Harry Spoelstra

@HarrySpoelstra

9 months

❗️Excellent new CardioVascular Autonomic dysfunction(CVAD) overview: For one: "As well as global circulatory disturbances, CVAD in post-COVID-19 syndrome(LongCovid) can manifest as microvascular and endothelial dysfunction, with local symptoms such as headache, brain fog, chest

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Harry Spoelstra

@HarrySpoelstra

8 months

❗A special for C19 CardioVascular impact minimisers, (young)people are dying, not direct from (mild)C19, but months later, from the damage inflicted by C19…….and what makes it even worse…..many will forget to make the association, with subsequent underreporting.

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Harry Spoelstra

@HarrySpoelstra

11 months

Beyond the acute illness: Exploring long COVID and its impact on multiple organ systems Nice overview article, but again and again, a call to wake-up! "The goal of this review is to carefully evaluate the clinical signs and symptoms of long COVID, their underlying causes, and

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Harry Spoelstra

@HarrySpoelstra

1 year

A TOP scientist who deserves our utmost attention: "I get that people want to move on from the pandemic, but the virus is still out there, people are getting infected, and there’s the possibility of developing long Covid. I’m still wearing masks and following preventive practices

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Harry Spoelstra

@HarrySpoelstra

1 year

CDC update: 20% #LongCovid "As more persons are exposed to and infected by SARS-CoV-2, reports of patients who experience persistent symptoms or organ dysfunction after acute COVID-19 and develop post-COVID conditions have increased"

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Harry Spoelstra

@HarrySpoelstra

6 months

Are we underestimating the C19 cognitive impact, especially after reinfections? 🤔 Bear with me..... Diner last night with good friends and after some time I noticed that the lady of the house had "changed", that was not the lady I knew 4 months ago... 😱 I carefully opened my

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Harry Spoelstra

@HarrySpoelstra

8 months

COVID’s Damage Lingers in the Heart ❗Harvard Medical school article worth some minutes of your time! ➡️"Evidence altered how COVID-19 was viewed; previously considered primarily a form of pneumonia, it now took on a coronary dimension. We began to understand that it’s also a

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Harry Spoelstra

@HarrySpoelstra

2 months

AJ, thanks, great educational video for many, and I'll take the opportunity to add an extra trick for people, like me, with glasses, using a 10-12cm 3M micropore stretch. This makes the nose bridge fit airtight without your glasses getting fogged up. 😷 Note: I've a difficult

AJ Leonardi, MBBS, PhD

@fitterhappierAJ

2 months

I’ve made a video on how to put on an effective mask to better prevent Covid infections after hearing about David Lynch This does not constitute medical advice, and look into fit testing with your assistants if you want extra security However this has worked for me

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Harry Spoelstra

@HarrySpoelstra

1 year

Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers ❗More #LongCovid Vagus nerve science with elegant explanation diagrams ➡️"Patients with Long COVID experience a cardiovascular autonomic imbalance known as

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Harry Spoelstra

@HarrySpoelstra

8 months

Lung function trajectories in mild COVID-19 with two-year follow-up ❗Damm, I was already afraid of this❗ “Our results indicate that mild COVID-19 infection affects lung function at time of infection with limited recovery two years after infection” ➡️Limited= nearly NO

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Harry Spoelstra

@HarrySpoelstra

10 months

@StoneColdPillar He walked away and my practice has HEPA with CO2 monitoring, always under 800ppm. 👍

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Harry Spoelstra

@HarrySpoelstra

1 year

"Receiving an mRNA vaccine was NOT associated with an increased risk of worsening heart failure, myocarditis, venous thromboembolism, or all-cause mortality" in a large and well performed study on patients with Cardiac failure! 👏 👇 #mRNAvaccines

Tyler Black, MD

@tylerblack32

1 year

Danish study Cardiac Study of 100,000 patients with documented heart failure In 90 days, vaccination showed DECREASED all-cause mortality and NO CHANGE to heart mortality.

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Harry Spoelstra

@HarrySpoelstra

1 year

Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes. Sit down and let this sink in…… ➡️"According to the results of the In-Silico, it is evidenced a natural evolution of the Betacoronavirus genera in order to balance propagation, infectivity and

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Harry Spoelstra

@HarrySpoelstra

8 months

You know what its like to be hit by a sickness avalanche…😖 Having recently had C19. Within 6 weeks contracting a CO-INFECTION C19 again but now with Influenza A(PCR confirmed/C19 RAT was neg) Haven’t been so f.cking sick in many, many years…… and still am, but recovering,

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Harry Spoelstra

@HarrySpoelstra

11 months

Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent? ➡️"The long-term complications of this SARS-Cov-2 is still under investigation" ➡️"SARS-CoV-2 can employ various strategies to potentially cause cancer in different organs" ➡️"SARS-CoV-2 infects

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Harry Spoelstra

@HarrySpoelstra

5 months

Hi Muriel, you're a historian with a PhD. Nice, but clearly without any objective medical knowledge. No problem here. But let me, as a medical professional with a PhD, tell you, subsequently, you are ill informed and can't recognise the BS you're spreading! Masks work, have

Muriel Blaive, PhD

@MurielBlaivePhD

5 months

@JennaLuche Hi Jenna, and thank you for this. I take this chance to clarify once again that I didn't mean to poke fun at the other lady or at you. What I meant is that under Covid, we have created a society in which many of us believe that infection and death are unacceptable and can be

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Harry Spoelstra

@HarrySpoelstra

1 year

"Compelling and reliable evidence that #SARSCoV2 infection is linked to a substantially increased risk of developing diverse new-onset AUTOIMMUNE diseases after the acute phase of SARS-CoV-2 infection" #LongCovid 🔥

High risk of autoimmune diseases after COVID-19

Nature Reviews Rheumatology - The full picture of post-COVID-19 autoimmune diseases and their prevalence is lacking despite numerous case reports and small series. Two studies that use large...

www.nature.com

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Harry Spoelstra

@HarrySpoelstra

1 year

With incoming studies, important #LongCovid numbers confirmed ➡️After Omicron infection: 9,7% ➡️Omicron REINFECTION: 20%(+100%)❗ ➡️Unvax nearly doubled their LC risk compared to vaccinated with Omicron Clear increased LC risk after Omicron REINFECTIONS😷

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Harry Spoelstra

@HarrySpoelstra

1 year

COVID−19 hospitalization increases the risk of developing glioblastoma: a bidirectional Mendelian-randomization study ❗Study “suggests that cancer development is one such foreseeable COVID-19 sequelae since chronic inflammation is long-established to be a fertile ground for

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Harry Spoelstra

@HarrySpoelstra

5 months

Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study ❗We’re now at TWO years…… if anybody still thinks that this will resolve in the further future..….😢 and what now with multiple C19 infections? ➡️Post "MILD" C19 included! ➡️"This

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Harry Spoelstra

@HarrySpoelstra

1 year

Are you troubled with BA.2.86, you should be, but with the worldwide circulating Omicron-subvariants, there’re also others to follow closely today and …..more appearing every day. SarsCoVC2 is attacking from several sides now, like swarm of angry bees, it has become far more

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Harry Spoelstra

@HarrySpoelstra

1 year

TOMORROWLAND 2023 Belgium: A potential world-wide super spreader event, mark my words! - 200K festival visitors from >100 countries, in 3d - Nearly all ages - Packed, dancing, singing, shouting, outdoors, but also indoor events - Packed camping is small tents, Hotels full -

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Harry Spoelstra

@HarrySpoelstra

3 years

Some news going around in anticipation of published data(2-3w), that after #Omicron infections lymphocytopenia is observed with CD4/CD8 depletion with other important immune system components compromised. Post-infectious only/prolonged, many question? #worrisome , Need more info🔥

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Harry Spoelstra

@HarrySpoelstra

1 year

COVID-19-related premature ovarian insufficiency: case report and literature review ❗Premature ovarian insufficiency (POI) as a irreversible LongCovid manifestation! ➡️"There is a strong molecular basis for a possible effect of SARS-CoV-2 infection on the female reproductive

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Harry Spoelstra

@HarrySpoelstra

11 months

High Risk of Heart Tumors after COVID-19 ❗Hell NO, but we already warned that this might be possible😠 ➡️"The detection of SARS-CoV-2 persistence in endothelium and macrophages as well as in tumor cells of benign and malignant cardiac neoplasms, the increase in the number of

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Harry Spoelstra

@HarrySpoelstra

5 months

❗️And there we go again: "Our findings demonstrate that SARS-CoV-2 infection seems to have a LONG-TERM impact on the brain, even in patients who presented mild acute disease." ➡️ Braindamage🔥

Long COVID: plasma levels of neurofilament light chain in mild COVID-19 patients with neurocognit...

Molecular Psychiatry - Long COVID: plasma levels of neurofilament light chain in mild COVID-19 patients with neurocognitive symptoms

www.nature.com

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Harry Spoelstra

@HarrySpoelstra

1 year

❗Long-term effects of SARS-CoV-2 infection on human brain and memory ➡️"Because of the huge number of SARS-CoV-2 infectious cases, even 10% patients with Long-COVID symptoms can cause heavy burden to human society" ➡️"The effects of SARS-CoV-2 infection on human brain and

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Harry Spoelstra

@HarrySpoelstra

1 year

SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients: "Altogether, these data indicate that HERV-W ENV does not simply represent a biomarker of #COVID19 severity or evolution but is also likely to be a

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Harry Spoelstra

@HarrySpoelstra

1 year

"In a way, SARS-COV-1(❗️) infection is similar to HIV infection that causes AIDS. Although HIV attacks and destroys the target cells slowly, particularly lymphocytes, SARS virus infects and destroys the immune cells in a much faster and more devastating fashion"😬, ➡️ indeed 👇

Emmanuel

@ejustin46

1 year

LONG SARS1 !!! EVERYTHING was already KNOWN in 2005! "We have demonstrated widespread dissemination of the SARS virus in the immune cells of the blood, spleen, and lymph nodes, as well as in the epithelial cells of the lungs, trachea, ...

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Harry Spoelstra

@HarrySpoelstra

1 year

SARS-CoV-2 induced vasculitic skin lesions are associated with massive spike protein depositions in autophagosomes ❗Interesting and I've learned from it! ➡️"Cutaneous lesions occur in up to 20 % of all patients with COVID-19" ➡️"Besides viral exanthema, vesicular or

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Harry Spoelstra

@HarrySpoelstra

10 months

With BA.2.86*/ JN.1*(Pirola) it has become very clear, that vax, boost and relax hasn’t and will NEVER succeed in the ongoing pandemic battle with SARS2, it will only cause many more new cases, many more new hospitalisations, many more new deaths and many, many more LongCovid,

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Harry Spoelstra

@HarrySpoelstra

7 months

🔥"The growing body of research now confirms that COVID-19 should be considered a virus with a significant impact on the brain. The implications are far-reaching, from individuals experiencing cognitive struggles to the potential impact on populations and the economy."

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Harry Spoelstra

@HarrySpoelstra

1 year

Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19 ➡️"In summary, the SARS-CoV-2 virus can invade the brain and exert its neurological manifestation through binding to ACE2 on nerve cells and endothelial cells" ➡️"A sound body of evidence

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Harry Spoelstra

@HarrySpoelstra

9 months

Incredible, today big news in #Belgium , an astounding record high 10% are in sick-leave, women 2x > men! You can’t imagine the ventilated BS trying to explain this, but NOT A WORD about C19/LongCovid😠 "Ziekteverzuim klimt naar recordhoogtes: werknemers 10 procent van de

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Harry Spoelstra

@HarrySpoelstra

1 year

CHILDREN play a KEY role in the transmission of many infectious diseases, C19 included. A Dutch study ➡️4059 school-households SARSCOV2 transmissions were identified: ➡️51.9% between primary schoolers ➡️19.6% between primary and secondary schoolers ➡️28.5% between secondary

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Harry Spoelstra

@HarrySpoelstra

8 months

Cardiac arrhythmia in COVID-19 patients ❗Interesting article reviewing recent science in the field of pathophysiology and etiology of arrhythmia in patients with C19 infection. ➡️“COVID-19 is a life-threatening disease” ➡️“Strong stimulation of the immune system and the

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Harry Spoelstra

@HarrySpoelstra

1 year

Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent? ➡️"The cancer-related effects of #SARSCoV2 proposed in this article are based on the ABILITY of the virus and its proteins to cause CANCER but that the long-term consequences of this infection will

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Harry Spoelstra

@HarrySpoelstra

9 months

Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis ❗Fellow colleagues, wake-up, there’s NO EXCUSE anymore to minimize Cardiovascular LC, alarm bells are sounding worldwide, here's another one👇 ➡️"With ever-increasing COVID-19 cases,

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Harry Spoelstra

@HarrySpoelstra

9 months

High Cardiac Troponin Levels in Infants with Acute SARS-CoV-2 Infection: A Prospective Comparative study ❗Preprint, but I hate the thought already, elevated Troponin in 30%! ➡️A total of 152 infants (67, 44.1% female; median age 65.5 days IQR 112.8) admitted for COVID-19(

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Harry Spoelstra

@HarrySpoelstra

2 years

Eyes are starting to open! #Hepatitis #Children Japanese researcher suggests ties between omicron variant and severe hepatitis in children | The Japan Times

Japanese researcher suggests ties between omicron variant and severe hepatitis in children

Professor Hiroshi Nishiura told the coronavirus advisory board that countries with larger omicron infection rates report higher numbers of childhood hepatitis.

www.japantimes.co.jp

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Harry Spoelstra

@HarrySpoelstra

1 year

COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway ❗Finally we’re getting closer to understanding the underlying mechanisms, maybe even finding therapeutic possibilities, that of course need further

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Harry Spoelstra

@HarrySpoelstra

1 year

Disturbing news on EG.5.1: #Preprint ➡️"EG.5.1 exhibits a higher effective reproduction number compared with XBB.1.5, XBB.1.16, and its parental lineage (XBB.1.9.2), suggesting that EG.5.1 will spread globally and outcompete these XBB subvariants in the near future" ➡️Further:

bioRxiv

@biorxivpreprint

1 year

Antiviral efficacy of the SARS-CoV-2 XBB breakthrough infection sera against Omicron subvariants including EG.5 #bioRxiv

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Harry Spoelstra

@HarrySpoelstra

1 year

AGAIN COVID19 is NOT the same as the FLU, even more so for Professional sporters! ➡️Latest updated guidelines: Return to sport or strenuous activity following infection: Coronavirus disease 2019 (COVID-19) illness in athletes – Athletes and heavy laborers recovering from

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Harry Spoelstra

@HarrySpoelstra

3 months

As predicted, "a virus" according to msm is hitting the Tour de France, no surprise...its of course C19.😷 Masks are reappearing and some believe in hand sanitizers again. 😢

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Harry Spoelstra

@HarrySpoelstra

1 year

Waning protection after vaccination and prior infection against COVID-19-related mortality over 18 months ➡️Probably for many an inconvenient truth🤔 “In conclusion, although vaccination and prior infection are protective against COVID-19-mortality, protection wanes

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Harry Spoelstra

@HarrySpoelstra

11 months

❗️"Infection with SARS-CoV-2 is associated with cognitive impairment equivalent to 10.6 years of normal aging and a 59.8% increase in mild cognitive impairment" ➡️🧵

Vipin M. Vashishtha

@vipintukur

11 months

2-LongCovid & severe disease appeared to accelerate the cognitive deterioration, especially in executive function. Cognitive impairment affects daily, occupational, & social functioning. 6/6

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Harry Spoelstra

@HarrySpoelstra

1 year

Autonomic dysregulation in long-term patients suffering from Post-COVID-19 Syndrome assessed by heart rate variability ❗Elegant study with more Vagus nerve impairment ➡️"Our data demonstrate persistent heart rate variability (HRV) alterations in PCS(LongCovid) patients with

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Harry Spoelstra

@HarrySpoelstra

1 year

The media waking up? "For up to a year after a COVID-19 case,people may be at increased risk of developing new heart-related problems,anything from blood clots and irregular heartbeats to a heart attack, even if they initially seem to recover just fine"

COVID-19 took a toll on heart health and doctors are still grappling with how to help

COVID-19 has taken a toll on the nation's heart health but how profound is only starting to emerge. Heart attack deaths spiked early in the pandemic, erasing years of progress in battling cardiovas...

apnews.com

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Harry Spoelstra

@HarrySpoelstra

5 months

🔥High time to wake up! SarsCoV2 is trying to stay in some patients, sorry to say….I warned you! SarsCoV2 causes T-cell damage, can persists and now more science that its also able to further infect your bone marrow……. and you still think its only the Flu😠 ➡️Megakaryocyte

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Harry Spoelstra

@HarrySpoelstra

9 months

🔥 Listen between her lines, @WHO is warning for the ongoing pandemic, but also for a new one, a growing LongCovid pandemic😡 Tbh, this is your fault, putting the world's population at this double risk, pushing a minimalistic discourse and or course, governments following it 😷

United Nations Geneva

@UNGeneva

9 months

" #COVID is still a global health threat, and it's causing far too much burden when we can prevent it. Five, ten, years from now, what are we going to see in terms of cardiac impairment, of pulmonary impairment of neurologic impairment? We don't know." - @mvankerkhove of @who

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Harry Spoelstra

@HarrySpoelstra

1 year

The bigger surprise, the new BA.2.86 sample(USA, traveler from Japan) has no genomic connection to neither the Danish nor the Israeli branch. This makes the picture only more complicated as there must already be an ongoing worldwide spread! Trashed testing and surveillance

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Harry Spoelstra

@HarrySpoelstra

1 month

Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC 🔥🔥US study with alarming data and conclusions that need our attention! #Mitigation ➡️“In this study, we demonstrate that mild SARS-CoV-2 infection

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Harry Spoelstra

@HarrySpoelstra

15 days

🔥 Dutch study: "There was significant EXCESS mortality among people from the general population WITHOUT a C19 vaccination in 2021+2022, with actually an UNDER-mortality among vaccinated people." ➡️ Results even more pronounced in risk patients! 🤔

Ondersterfte bij COVID-19-gevaccineerden en oversterfte bij ongevaccineerden | MedNet

Onder mensen zonder COVID-19-vaccinatie was er in 2021-2022 sprake van oversterfte; onder gevaccineerden juist van ondersterfte.

www.mednet.nl

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Harry Spoelstra

@HarrySpoelstra

1 year

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication ❗How SarsCoV2 uses ACE2, the cunning bastard ➡️"ACE2 as a pivotal signaling protein in SARS-CoV-2 spike protein-mediated activation of pro-inflammatory signaling and

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Harry Spoelstra

@HarrySpoelstra

1 year

COVID-19 can affect the heart Strong article from sept 2020 by @EricTopol , 3y's later only finding broader confirmation as LongCovid, with still many Q's not answered! ➡️Interesting paragraph: "Cardiac involvement in athletes has further elevated the concerns", bad news for

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Harry Spoelstra

@HarrySpoelstra

1 year

Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors 👀❗ ➡️Concentrations of autoantibodies correlates to intensity of neurological disorders including psychomotor speed,

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Harry Spoelstra

@HarrySpoelstra

1 year

🔥SARS-CoV-2 infection causes a prolonged increase in the pro-inflammatory transcriptional status that could predispose post-acute patients to the development of long-term health consequences, including autoimmune disease, reactivation of other viruses and disruption of the host

Emmanuel

@ejustin46

1 year

"We discovered that SARS-CoV-2 infection leads to a prolonged alteration of the gene expression profile of circulating T, B and NK cells and monocytes" 😨

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Harry Spoelstra

@HarrySpoelstra

10 months

Study on brain damage patterns of COVID-19 patients based on EEG signals(Chinees study) ❗More evidence again and again........ just imagine your children😖 ➡️"The level of brain activity in COVID-19 patients(28 days post C19) at rest is reduced, and the brain functional

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Harry Spoelstra

@HarrySpoelstra

11 months

Evaluation of the retina, choroid and optic disc vascular structures in individuals with a history of COVID-19 ➡️"This is the first study in the literature to evaluate the post-COVID-19 changes in the vascular structures of the eye compared to the pre-disease values" ➡️"We

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Harry Spoelstra

@HarrySpoelstra

8 months

Attentional impairment and altered brain activity in healthcare workers after mild COVID-19 ❗Clearly not ideal for HCW’s and many other professionals! ➡️Patients with mild cases account for the majority of those infected with coronavirus disease 2019 (COVID-19). ➡️Attentional

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Harry Spoelstra

@HarrySpoelstra

3 months

I'm really fed up with individuals downplaying C19. It is a serious personal and broad society health danger with an increasing possible long-term impact for many! I see the C19 health consequences.....daily! 😡

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Harry Spoelstra

@HarrySpoelstra

11 months

Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology ❗Can’t repeat this enough, urgent attention needed ➡️"Cardiac complications are an increasingly recognised complication of COVID-19 and convey a high burden of morbidity and mortality" ➡️"Cardiac

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Harry Spoelstra

@HarrySpoelstra

7 months

Current clinical findings of acute neurological syndromes after SARS-CoV-2 infection ❗More BRAIN DAMAGE with Omicron: Intriguing study with hospitalized C19 patients😷 ➡️"The Omicron variant, distinguished by heightened neurotropism, penetrates the CNS via the olfactory bulb.

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Harry Spoelstra

@HarrySpoelstra

1 year

As I’m no #LongCovid specialist in general, neither are you @TWenseleers and respectfully, you’re not even a clinician, but I am, and today I may say a CVD related LongCovid specialist after 3 y’s of doing my best to keep up to date on this saddening topic, with only ONE focus,

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Harry Spoelstra

@HarrySpoelstra

5 months

Accelerated tumor progression after COVID-19 infection in patients with glioblastoma: a retrospective case-control study ❗Not the news I wanted to read, forwarded to me by a USA colleague(not on X). ➡️"Patients with glioblastoma may have accelerated disease progression in the

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Harry Spoelstra

@HarrySpoelstra

1 year

Hematopoietic responses to SARS-CoV-2 infection, a study revisited! ➡️"While COVID-19 starts as a respiratory tract infection, it is considered a systemic disease which profoundly alters the hematopoietic system" ➡️"Lymphopenia, neutrophilia, thrombocytopenia, and stress

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Harry Spoelstra

@HarrySpoelstra

1 month

🔥"We will need to be prepared to deal with LC for a GENERATION" "This is important because there remains a common misperception that pediatric long COVID is rare, and this research can raise awareness of its impact on children.” ➡️ WAKE-UP PAEDIATRIANS👇❗️

IFLScience

@IFLScience

1 month

Long COVID Affects Kids And Teens Too, And We're Now Starting To Learn How

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Harry Spoelstra

@HarrySpoelstra

1 year

IMPORTANT: ❗New evidence that the #SARSCoV2 S-protein ➡️may have a direct pathogenic action on cardiac pericytes with subsequent damaging of the heart’s microvasculature, through pericyte detachment, death, and decreased vascular coverage, thus disrupting the coronary

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Harry Spoelstra

@HarrySpoelstra

25 days

🔥"SARSCoV2 triggers a new airborne form of Acquired Immune Deficiency Syndrome: “CoV-AIDS” #WorldHealthNetwork "This is NOT AIDS as we know it from human immunodeficiency virus (HIV) infection, it is a NEW type of acquired immunodeficiency syndrome with different deleterious

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Harry Spoelstra

@HarrySpoelstra

1 year

Hear a lot that with the new Omicron subvariants, the vulnerable are only of concern, well....than I have news for you! You, yes, probably you too, have or will maybe become the vulnerable today after one or more covid-19 episodes. Your acquired post-infection/vaccine immunity

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Harry Spoelstra

@HarrySpoelstra

1 year

"Despite the call for variant-specific vaccines, an increase in number of vaccine booster doses with NVX-CoV2373(Novavax) enhances immunogenicity for the ancestral SARS-CoV-2 strain and its variants(Omicron) without a notable increase in reactogenicity. Therefore, these data

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Harry Spoelstra

@HarrySpoelstra

1 year

“COVID-19 is a multisystemic disease that mainly affects and causes dysregulation of the endothelium, causing systemic manifestations.” Interesting: ➡️A nailfold video capillaroscopy(NVC) is a safe, easy, and noninvasive method to evaluate microcirculation alteration, like we

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