Antonio Bertoletti @Anto_Berto Twitter profile

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@mariqta_

@AlisSistersClub

Antonio Bertoletti

@Anto_Berto

2 years

Italian aperitivo. You need to live abroad to understand such beauty. For my Italian friends is just normal..

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Antonio Bertoletti

@Anto_Berto

3 years

I vaccini servono x proteggere da malattia grave. E’ passato invece il concetto che vaccino e’ solo produzione di anticorpi e che se questi calano e’ finita. Direi che l’enorme disparità’ tra casi di infezione e malattia dimostra il contrario. Grazie memory B and T cells.

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Antonio Bertoletti

@Anto_Berto

2 years

Everybody keeps talking about antibody-escaping variants… Nice work from Andrew Godking is showing how magnitude of T cell response against SARS-CoV2 structural proteins (M,NP and Spike) correlates with protection against COVID-19 more than Ab. Go T cells

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Antonio Bertoletti

@Anto_Berto

3 years

COVID-19 testing turns to T cells | Nature Biotechnology ....l hope that the forward looking reviewers of my 4 rejected grants about studying T cells in Covid19 will read it and start to realise that there isn’t only antibodies against viral disease😜

COVID-19 testing turns to T cells

Nature Biotechnology - A diagnostic test based on sequencing long-lived SARS-CoV-2–specific memory T cells provides a complement to antibody testing for determining previous exposure to...

www.nature.com

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Antonio Bertoletti

@Anto_Berto

2 years

@readthinkwalk It might be the difference between living and not just surviving.

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Antonio Bertoletti

@Anto_Berto

3 years

Three days ago 30% of SARS-2 infection were due to Omicron in Italy. The reason of why all the flights from South Africa are blocked until 31st of January is an indication of the pathetic responses of all the governments., they need to just do something🤡.

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Antonio Bertoletti

@Anto_Berto

3 years

Quando questo esimio Neurobiologo cita che immunità’ vaccinale decade velocemente lo sa che esistono due cosette che si chiamano memory B and T cells? Che pena, immunità’ ridotta a titolo anticorpale nel sangue. Questa decade e allora? Scrivere di cose che si sanno magari?

Stefano Berto, PhD

@StefanoBerto83

3 years

Questo lo considero un bel pezzo di Giorgio con alcuni spunti riflessivi che condivido totalmente, soprattutto l’ultima parte riguardo la comunicazione.

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Antonio Bertoletti

@Anto_Berto

3 years

An interesting demonstration( in macaques) that CD8T cells present in the nasal mucosa protect from infection. T cells not only important for disease control but also protection( if located in the right place) Nice work! antibody-independent control.

Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced...

Ishii et al. show neutralization-independent SARS-CoV-2 control associated with vaccine-induced CD8+ T cell responses, indicating that virus-specific CD8+ T cell induction by intranasal vaccination...

www.cell.com

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Antonio Bertoletti

@Anto_Berto

2 years

Hypothesis are welcomed because they indicate us possible directions to understand the real mechanism of events. In this case the possibility that SARS-Cov2 secrete proteins that have superantigen like features

Petter Brodin

@BrodinPetter

2 years

Acute hepatitis in kids. We urge colleagues with access to samples (blood/liver tissue) to consider SARS-CoV-2 superantigen-mediated disease, potentiated by a second virus (AdV) 🧵1/

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Antonio Bertoletti

@Anto_Berto

3 years

Thanks Spanish Society of Immunology and Boulle Foundation. Nice to see new and old friends in Alicante. Here with Alba Grifoni and Alex Sette. Joint effort to show importance of T cells in SARS-2 infection. Missing Nina LE Bert. Go T cells!

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Antonio Bertoletti

@Anto_Berto

5 years

We will set up a platform to share info about HLA- restriction and immunodominance of the different #SARSCoV2 T cell epitopes.

Bertoletti Lab

@bertoletti_lab

5 years

Look at our first direct ex-vivo ELISpot! Strong #SARSCoV2 specific T cell response in recovered #COVID19 patients. An alternative to the antibody tests?

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Antonio Bertoletti

@Anto_Berto

3 years

@PGTimmune Very interesting and as somehow expected: repetitive exposure broadens the T cell repertoire. No apoptosis, deletion, exhaustion of T cells. T cell expert 😜 @fitterhappierAJ have you seen this?

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Antonio Bertoletti

@Anto_Berto

2 years

And no signs of immune deficit after SARS-CoV-2 infection, clearly. Nice work

Alessandro Sette

@SetteLab

2 years

Impact of SARS-CoV-2 exposure history on the T cell and IgG response Yet another awesome work of this outstanding group. Thanks for including us in the collaboration!

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Antonio Bertoletti

@Anto_Berto

2 years

Oh yes.. let’s live the rest of our life alone without any human interaction. Let’s forget that we have an immune system that it is able to cope with infection 99.99% of the cases. (Uh .. but Professor do you have data to support this? )blah.. blah .. bla

Kit Yates

@Kit_Yates_Maths

2 years

I love this video from RIKEN in Japan. It models the flow of exhaled air in various different settings under different conditions. As well as the flow patterns being very beautiful, it also highlights the importance of good quality masks (FFP2/FFP3)

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Antonio Bertoletti

@Anto_Berto

2 years

But we have also T cells….

Danny Altmann

@Daltmann10

2 years

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants 'Serum neutralization was markedly reduced, including with the bivalent booster All clinical monoclonal antibodies were rendered inactive against these variants'

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Antonio Bertoletti

@Anto_Berto

2 years

What is tragic is that people put at the same level D Altman with AJ. A scientist who worked on antiviral T for all his carrier and a person who has not done a single work on T in infected people but likes to act as the “ revolutionary scientist” excluded by the establishment.

Danny Altmann

@Daltmann10

2 years

I believe what I said was that I didn’t know if T cell exhaustion is a thing here. That is, 2 studies show raised expression of PD-1, a correlate of exhaustion. Thats many studies away from saying there’s functional impairment and even further from saying T cells are ‘damaged’

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Antonio Bertoletti

@Anto_Berto

2 years

The dogma that inactive virus vaccines are weak is questionable. Yes, low antibodies but good T cells recognising multiple SARS-2 proteins and not only Spike. In the Omicron era this might be an advantage for disease protection. Thanks @CellRepMed to publish our work.

Cell Reports Medicine

@CellRepMed

2 years

Online now: A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or Inactive virus COVID-19 Vaccines

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Antonio Bertoletti

@Anto_Berto

2 years

The president of Singapore Society of Immunology Florent Ginhoux. Finally not a virtual meeting ⁦ @FGinhoux ⁩

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Antonio Bertoletti

@Anto_Berto

2 years

Can we start to first demonstrate directly that some proteins of SARS2 have real superantigen features and act really as a superantigen.? Building hypothesis over an hypothesis can be dangerous. ( sorry for the misspelling and English grammar).

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Antonio Bertoletti

@Anto_Berto

2 years

Or that the incidence of SARS-CoV-2 infection/ COVID 19 is higher in individuals who have already other pathologies and as such are more at risk of dying.

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Antonio Bertoletti

@Anto_Berto

2 years

I am convinced that the new direction of SARS-CoV2 research ( and vaccine development ) should be directed towards the primary site of infection if we want to improve infection and disease protection.

Bertoletti Lab

@bertoletti_lab

2 years

Our new study @JExpMed explores tissue-resident SARS-CoV-2-specific T cells at the site of primary infection - 👃🏼(nose)

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Antonio Bertoletti

@Anto_Berto

3 years

Tired of Covid discussion. The new olives harvest in Italy. Good oil in 2022.

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Antonio Bertoletti

@Anto_Berto

2 years

A lot of interest on vaccines triggering nasal immunity. We found Nasal resident virus specific T ( both 8 and 4) only in vaccinated after breakthrough infection. Thus current vaccines don’t elicit nasal immunity but people with hybrid immunity highly protected.

Bertoletti Lab

@bertoletti_lab

2 years

🚨Our new preprint shows that broadly-specific SARS-CoV-2 nasal resident T cells were detected in vaccinated individuals after breakthrough infection!👃🏼🤧

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Antonio Bertoletti

@Anto_Berto

2 years

Hmm. Lab interest switched. HBV then SARS-CoV-2 T cells and now coffee brewing. Not sure we can get a grant.

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Antonio Bertoletti

@Anto_Berto

1 year

New data about the importance of T cells in SARS-CoV2 viral and disease control. Nice study of T cell adoptive transfer in severe COVID-19. Congratulations! SARS-CoV-2-specific T cell therapy for severe COVID-19: a randomized phase 1/2 trial | Nature Med

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Antonio Bertoletti

@Anto_Berto

2 years

“We need to focus on broadening our immune response.. “ and all the article is only about antibodies. It is two years that T cell immunologist repeat that immunity against Sars2 is not only Spike specific antibodies. What can we do?

Eric Topol

@EricTopol

2 years

"Based on its immunological profile, it [Omicron & its subvariants] should be called SARS-3" @gretchenvogel @NewsfromScience w/ @K_G_Andersen @Tuliodna @linfa_wang

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Antonio Bertoletti

@Anto_Berto

2 years

An easy assay to quantify SARS-CoV2 T cells directly in whole blood. Easy to implement in lab with standard equipment. We need more data to define even better the T cell role in disease ( not infection) protection. Great collaboration.

GuccioneLab

@GuccioneLab

2 years

Excited for this amazing international collaboration to finally get published. @Anto_Berto We now have a scalable way to assess SARS-CoV-2 cellular (T Cell) immunity!

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Antonio Bertoletti

@Anto_Berto

3 years

So Sweden approach wasn’t so bad…

Daniele Bianchi

@WhitesPhD

3 years

Brilliant graph…

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Antonio Bertoletti

@Anto_Berto

3 years

Let’s re-tweet ( possible?) what we know about T cells and Omicron. Relaxing read for Sunday. Remember: we still need more info, but what we know is not bad.

Bertoletti Lab

@bertoletti_lab

3 years

So, there is a new variant Omicron (B.1.1.529) 30AA substitutions, 3 deletions, 1 insertion in the Spike protein Great concern about escaping Spike-specific antibodies! This is important; but what about T cells? They might not protect from infection, but likely from disease: 🧵

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Antonio Bertoletti

@Anto_Berto

3 years

Red carpet in Maremma. On the anniversary of Nature article publication local authority organised a small celebration….

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Antonio Bertoletti

@Anto_Berto

2 years

Starting to better define immunity at the site of SARS2 infection( that is not the blood). New work showing that mucosal immunity poorly induced by parenteral vaccination.

Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination

COVID-19 mRNA vaccines induce poor anti-Omicron mucosal immunity, but this immunity can be boosted with an intranasal immunization.

www.science.org

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Antonio Bertoletti

@Anto_Berto

4 years

We need to understand whether SaRsCov2 T cells can protect the host from development of severe disease. T cells test should be easier and became routine.

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Antonio Bertoletti

@Anto_Berto

3 years

@andcapocci @BiologiScienza @CapitanBanana33 E’ facile capire che in una infezione virale che causa malattia severa nel 5-30% (Age dependent) degli infettati adulti non vaccinati - terapie anche a base di coda di lucertola avranno una grande efficacia(senza control group). Questa infezione e’ perfetta x i ciarlatani.🤷🏻‍♂️

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Antonio Bertoletti

@Anto_Berto

3 years

What an honour. Good Easter to everyone.

Italy in Singapore

@ItalyinSG

3 years

👨‍🔬👩🏻‍🔬 “Italian research day in the world 2022” 🇮🇹🤝🇸🇬We celebrate four of our finest researchers who brilliantly represent #Italy in #Singapore 🎥 Interview 1/4: Antonio Bertoletti, Full Professor at @dukenus and infectious disease specialist 🔗

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Antonio Bertoletti

@Anto_Berto

4 years

A big thanks to all the lab and collaborators. Hope that these data will help to evaluate more rationally our current approach to COVID19 pandemic.

Bertoletti Lab

@bertoletti_lab

4 years

Our paper about #SARSCoV2 -specific #tcell immunity in cases of #COVID19 and #SARS , and uninfected controls is now out, peer-reviewed and published in @nature ! 3 take-home messages: (1/5)

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Antonio Bertoletti

@Anto_Berto

1 year

Two beautiful days at Karolinska, discussing human immunology with great scientists. In addition , nice food and an unexpected beautiful sunny weather. Thanks a lot Margaret Chen, @marcus_buggert , @bjorkstrom_lab , @MjosbergL , @KlingstromLab and many others. Back to Singapore now.

Mjösberg Lab

@MjosbergL

1 year

Great talk today by @Anto_Berto ! Thanks for presenting your reach on T cells and #SARSCoV2 !

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Antonio Bertoletti

@Anto_Berto

3 years

@IgnazioMagnani @SilvestriMd Ma discutere di cosa? Se la luna e’ una formaggia? Si discute se si condividono i metodi di analisi. Se questi non ci sono su cosa discuti? Le farneticazioni di un caro signore che 20 anni fa inciampo’ su HIV ( grazie alla sua post-doc) si devono perdere nel vento)

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Antonio Bertoletti

@Anto_Berto

11 months

Hello @fitterhappierAJ . Are you going to comment this in your 🎪? Let me know. It will be a good show. What did you say.. overwhelming evidences of progressive T cell exhaustion after SARS2 infection in everyone…( tested by you in your kitchen.. I suppose.). All the best.

Eric Topol

@EricTopol

11 months

Vaccination after Covid does not lead to T cell exhaustion—it invigorates T cell functionality @SciImmunology @marcus_buggert

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Antonio Bertoletti

@Anto_Berto

2 years

Happy to be in such nice company! An honor🍾🍾

Duke-NUS Medical School

@dukenus

2 years

Congratulations to six of our Duke-NUS researchers, who were named among @Clarivate 's Highly Cited Researchers! Read more about it at . #DukeNUSResearch #MakeGreaterThingsHappen @linfa_wang @Anto_Berto @lamcardio @shirinklmddn

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Antonio Bertoletti

@Anto_Berto

2 years

I would like to point out that DR Ladhani is a pediatric infectious disease specialist…not the first depressed ex PhD student.

Shamez Ladhani

@ShamezLadhani

2 years

People don’t realize that, even if masks helped protect against respiratory viruses, masking kids now would only ⬆️ susceptible pool of kids in the next infection wave & overwhelm healthcare systems further. Lockdowns & restrictions are why we are in this mess in the 1st place 👇

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Antonio Bertoletti

@Anto_Berto

3 years

How nice are small Italian cities? This is Cremona. My home town. When I was living here this beauty seems normal.

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Antonio Bertoletti

@Anto_Berto

3 years

Back in Singapore. 14 days quarantine despite more cases in Singapore than in Italy as % and despite being vaccinated. But the best is the portable device fixed to your arm to control that you are not leaving your house. ..building trust.

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Antonio Bertoletti

@Anto_Berto

3 years

Ventilation is the key to prevent infection. But at Duke-Nus we cannot eat or drink outside. Everyone eating inside but 1 m apart and with stupid plastic barrier . One example of ignoring the facts. Why Did It Take So Long to Accept the Facts About Covid?

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Antonio Bertoletti

@Anto_Berto

2 years

The 12th Singapore Society for Immunology Annual Symposium starting tomorrow! Looking forward to a real meeting to meet many friends. Not hybrid😎. See you tomorrow ⁦⁦ @dukenus ⁩

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Antonio Bertoletti

@Anto_Berto

3 years

@YanezPeter Fammi capire Yanez. Quindi dobbiamo ragionare solo in termini di o bianco o nero? Niente grigio? O tutti morti o solo raffreddore? Dire che in generale e’ meno patologico e’ colpa grave anche se è’ la realtà’? Comunque pensate quel che volete

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Antonio Bertoletti

@Anto_Berto

2 years

Less than 10 deaths for 1 million . This is the impact in the general population of BA.5 . Then everyone can decide . Vaccination seems to work quite well in protection from disease. Not perfect ( would be better to have zero infection) yes , but not bad

Eric Topol

@EricTopol

2 years

Or about potential impact on hospital admissions? Or what happened in Portugal may not be isolated to Portugal?

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Antonio Bertoletti

@Anto_Berto

2 years

#SACovidWorkshop2022 T cells ( Alba Grifoni and Antonio Bertoletti) surrounding B cell ( Miles Davenport) killing or helping? @Alba_Grifoni

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Antonio Bertoletti

@Anto_Berto

1 year

A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection Nice to see these clear evidences of the importance of T cells in protection from SARS-CoV2 induced disease. Congratulations to the authors. I really enjoyed it.

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Antonio Bertoletti

@Anto_Berto

2 years

The ability of antibodies elicited by current vaccines to protect from Omicron infection is close to zero....and we are still discussing only about antibodies...There is no hope. Thanks God that the real immunity is not only based on quantity of antibodies in serum..

Eng Eong Ooi

@EngEongOoi

2 years

Fortunately, there are memory B and T cells. Next Covid-19 wave could emerge as people's antibodies wane: Ong Ye Kung

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Antonio Bertoletti

@Anto_Berto

3 years

Here where we are. Living in a golden jail for the rest of our life.. because better to be safe than sorry...In chasing zero Covid-19 infections, Hong Kong, Singapore, Australia | South China Morning Post

Opinion | Economies chasing zero Covid-19 infections are trapped by their own success

A reluctance to accept Covid-19 will become endemic means the early victors against the disease may be the last to reopen their economies, writes Donald Low.

www.scmp.com

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Antonio Bertoletti

@Anto_Berto

2 years

I have not seen these simple data. Maybe I am missing something and perhaps somebody can explain to me why we are only looking at indirect evidences of superantigen quality of Spike? Direct evidences should be easy to show. Conclusions:

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Antonio Bertoletti

@Anto_Berto

2 years

The superantigen theory is based on a work published in PNAS in 2020 ( Cheng et al PNAS 2020;117:25254) . The authors suggested based on in silico data that Sections of Spike have homology of sequence (with Staph enterotoxin B. The sequence should act as superantigen

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Antonio Bertoletti

@Anto_Berto

3 years

@cecchignola71 La domanda è’ corretta. Tuttavia un boost dopo 6 mesi sembra ampliare ulteriormente il nostro repertorio T e B con maggiore ampiezza della risposta in grado di riconoscere meglio varianti. Poi cose vuole non è’ tutto o bianco o nero. Stiamo imparando.

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Antonio Bertoletti

@Anto_Berto

2 years

SG guidelines, really? Infection not considered a boost because it is …better? 3 months after infection a boost ? In everyone with age > 12 years😪. A review of recent scientific literature seems necessary.

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Antonio Bertoletti

@Anto_Berto

4 years

Israel sees 60% drop in hospitalizations for age 60-plus 3 weeks after 1st shot | The Times of Israel

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Antonio Bertoletti

@Anto_Berto

1 year

@CriticalAerosol So happy that my son is not among the friends of your son. Poor boys. Treated like Guinea pigs.

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Antonio Bertoletti

@Anto_Berto

2 years

A nice consideration. We found similar pattern also in fully asymptomatic infected before vaccination. In many of them was actually a fast seroreversion ( see if interested Le Bert et al JExp. Med. 2021, 218. e20302617). Nice to be back to chat about science

Edward Nirenberg 🇺🇦

@ENirenberg

2 years

I can’t believe I have to say this but the fact that vaccinated people are less likely to seroconvert to nucleocapsid on infection with SARS-CoV-2 isn’t evidence of original antigenic sin- it is evidence that they clear the infection too quickly to get high doses of nucleocapsid.

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Antonio Bertoletti

@Anto_Berto

3 years

Go T cells go😎.nice work!

Tao Dong Group

@TaoDongGroup

3 years

🚨 Hot off the press today, our latest #COVID19 paper published with @SpringerNature in @NatImmunol shows that strong #CD8TCell responses to a #SARSCoV2 nucleoprotein epitope are associated with milder disease & better control of virus infection.

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Antonio Bertoletti

@Anto_Berto

2 years

Finally somebody that argues that excessive masking is not without consequences. I am sorry but like other part of our body immunity needs some constant “ training”.

The Lancet Infectious Diseases

@TheLancetInfDis

2 years

New Research: Epidemiology of respiratory syncytial virus in children younger than 5 years in England during the COVID-19 pandemic, measured by laboratory, clinical, and syndromic surveillance (1/2)

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Antonio Bertoletti

@Anto_Berto

2 years

@TactNowInfo @HhhPieter @Marc_Veld @wanderer_jasnah @MdFacep Yes my dear.. every single acute viral infection caused a reduction of circulating T cells ( except EBV) it is due to modification of the homing.. they are all reversible.

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Antonio Bertoletti

@Anto_Berto

2 years

Providing important information to patients already in difficult immunological situation. If you don't have a single antibody against Spike due to your B cell depletion therapy you can count on T cells.

Buckling up against COVID-19 after CAR T-cell therapy

In this issue of Blood, Atanackovic et al1 and Oh et al2 separately report on T-cell immune responses following severe acute respiratory syndrome coronavir

ashpublications.org

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Antonio Bertoletti

@Anto_Berto

11 months

Other evidence of the importance of T cells in control of viral induced disease(COVID in this case.).similar data in CART CD19 treated kids( see also doi:10.1182/blood .2022016166) | Science Translational Medicine

T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and...

SARS-CoV-2 infection and vaccination increases CD8+ T cell responses and reduces risk of severe COVID-19 in individuals with B cell deficiency.

www.science.org

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Antonio Bertoletti

@Anto_Berto

3 years

@BiologiScienza @barbarab1974 L’uso di parole complicate e fuori contesto e’ sempre stato usato x confondere. “ Si potrebbe cominciare dal Azzecagarbugli dei Promessi Sposi. Stessa tecnica. Certo che quello che scrive e’divertente. Porella

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Antonio Bertoletti

@Anto_Berto

2 years

It is about time to come to term with this. After a full vaccination schedule further boosts do little. It is infection ( in vaccinated) that protects better and longer. Certainly if you follow the absurd theory of SARS2 like HIV you will find this unacceptable.

Infectious Disease Ethics

@ID_ethics

2 years

"Boosters are not really providing any prolonged protection against transmission Natural infection is much more effective Allowing the virus to circulate in [low-risk groups] is probably the best way to protect the population" Sir John Bell, Oxford Professor of Medicine

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Antonio Bertoletti

@Anto_Berto

2 years

I am lost. Hospitals are empty. Isn’t this the best outcome and the simple demonstration that Singapore is coping with infection? . Article ends with a generic” be vigilant” what does it mean? Don’t live a normal life? Stay away to others? Sorry I disagree.

Duke-NUS Medical School

@dukenus

2 years

Dr Khoo Yoong Khean from the Duke-NUS Centre for Outbreak Preparedness discusses whether Singapore is ready for another COVID-19 wave in this recent commentary. Read more about it at . #DukeNUSResearch #covid19 @yoongkhean

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Antonio Bertoletti

@Anto_Berto

3 years

Thanks! Let's not forget that there are many viral infections waiting for affordable cure. HBV is still an important human pathogen despite success of vaccination.

Expertscape: Your Source For Medical Experts

@Daily_Experts

3 years

During World Hepatitis Day (Jul 28, 2021), we congratulate Dr. Antonio Bertoletti [Anto_Berto] of Duke-NUS Medical School -- Recognized as an Expertscape World Expert in Hepatitis B.

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Antonio Bertoletti

@Anto_Berto

3 years

We should really expand the antigenic repertoire of vaccines and deliver them in the nose. Interesting article. Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8+ T cell responses

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Antonio Bertoletti

@Anto_Berto

2 years

In silico data. No direct demonstration. Now a comment from an old T cell immunologist (me). Demonstrating that an antigen or section of it have superantigen like quality is not rocket get the protein(or a section) and you stimulate in vitro

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Antonio Bertoletti

@Anto_Berto

3 years

@YanezPeter Si . E il vaccino efficace x proteggere da malattia severa lo abbiamo. E più di uno. Vaccino protegge da malattia severa. Se qualcuno non lo vuole fare, mi spiace . E concentriamoci a mantenere alcune categorie molto protette( immunodrpressi e super anziani)

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Antonio Bertoletti

@Anto_Berto

2 years

PBMC of different individuals and you look directly whether such antigen activates Large repertoire of T cells with a particular V beta. It is simple and you don’t need fancy modelling and it is a direct demonstration.

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Antonio Bertoletti

@Anto_Berto

3 years

Congratulations to @SetteLab and @Alba_Grifoni for this important work. Very likely that the Low pathogenicity of Omicron in vaccinated is caused by preservation of T cell response in the majority of individuals.

Alessandro Sette

@SetteLab

3 years

Excited to see this out so quickly! Great team work, it was a huge amount of effort to get it done in such short time!

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Antonio Bertoletti

@Anto_Berto

3 years

A significant improvement of T cell therapy in Liver transplants with HCC. ⁦Duke-NUS Medical School and Lion TCR ink exclusive IP licensing agreement for immunosuppressive drug-resistant anti-cancer T-cells

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Antonio Bertoletti

@Anto_Berto

3 years

Better protection against SARS-CoV-2 from Heterologous vaccination (than homologous MRNA) . Different efficacy correlates to memory B cells and T cells quantity and not to antibodies titers. Nice.. the value of memory adaptive immunity. Great work

Immunogenicity and efficacy of heterologous ChAdOx1–BNT162b2 vaccination

Nature - An observational study of more than 13,000 healthcare workers shows that a prime–boost vaccine regimen of AstraZeneca ChAdOx1-S-nCoV-19 with Pfizer BNT162b2 provides enhanced...

www.nature.com

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Antonio Bertoletti

@Anto_Berto

3 years

Evidences of T cell exhaustion in Severe Covid 19 . Nice work of @BecherLab . It supports our observation of importance of early functional T cell response for Covid19 protection. . Go T cells. @Tcellexperts .

University of Zurich

@UZH_en

3 years

Severe cases of #COVID -19 can now be detected at an early stage. Researchers at the University of Zurich have identified the first biomarker that can reliably predict which patients will develop severe symptoms. This can help to improve their treatment.

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Antonio Bertoletti

@Anto_Berto

2 years

@EricTopol @NEJM 10 individuals, unknown history of previous infection, serology done 2 weeks after boost. Good that they see some effect on Omicron variants, but perhaps not sufficient to really demonstrate efficacy of 4 or 5 th vaccination( hey I am a strong believer of vaccine efficacy)

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Antonio Bertoletti

@Anto_Berto

2 years

Activation of Spike specific CD8 T cell correlate with virus decline. Nice data showing the importance of virus specific CD8 T cells in SARS-CoV-2 control

SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses

Our understanding of T cell responses to SARS-CoV-2 vaccination and breakthrough infection has lagged behind B cells and antibodies. Here, Koutsakos et al. utilize longitudinal sampling to demonstr...

www.cell.com

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Antonio Bertoletti

@Anto_Berto

2 years

I would like to understand why this “ perspective” is a milestone. If I understood ( read it twice) the message is : level of neutralizing antibodies does not work so well in predicting symptomatic COVID, but since it works a little we should continue to use. Ok. 🤷🏻‍♂️

Eric Topol

@EricTopol

2 years

Just out @NEJM , a "milestone" The level of neutralizing antibodies induced by Covid vaccines has been established as a correlate of protection, i.e. a surrogate endpoint for predicting clinical outcomes and use for regulatory approvals

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Antonio Bertoletti

@Anto_Berto

3 years

Ms Kamini Kunasegaran the real “ engine of my lab” shortlisted to be the “ Asian Tech of the year…” let s see if she will win.

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Antonio Bertoletti

@Anto_Berto

3 years

Agree. This is the consequence of the reduction of the complexity of our immune system only to antibodies. Innate immunity, NK, T cells ? Forget about it.

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Antonio Bertoletti

@Anto_Berto

2 years

What? Protection much higher with hybrid immunity? But infection shouldn’t wipe out progressively your B and T cells? let’s see what the 🤡Zero COVID are going to say. A list: the study is in young( ok). Look only at single infection,

Protection against symptomatic infection with delta (B.1.617.2) and omicron (B.1.1.529) BA.1 and...

Previous infection with any SARS-CoV-2 variant provided some protection against symptomatic reinfection, and vaccination added to this protection. Vaccination provides low-to-moderate protection...

www.thelancet.com

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Antonio Bertoletti

@Anto_Berto

2 years

I like this work of a very talented PhD student of the lab Joey Ming Er Lim. Studying how to improve antiviral immunity at the site of primary infection is the way to go .. go T cells.

Bertoletti Lab

@bertoletti_lab

2 years

Our new study @JExpMed explores tissue-resident SARS-CoV-2-specific T cells at the site of primary infection - 👃🏼(nose)

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Antonio Bertoletti

@Anto_Berto

4 years

@apoorva_nyc Yes.. but let’s not forget that if you have antibodies.., you have also T cells. In any case I hate this “better Antibodies.. no better T cells “ . A coordinate humoral and cellular immunity is always needed for viral control.

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Antonio Bertoletti

@Anto_Berto

3 years

As predicted T cells mainly preserved against Omicron.. go T cells and go @SetteLab . Similar findings by others labs ( Catherine Riou)

David R. Martinez

@David_RMartinez

3 years

Very important study from @SetteLab @Alba_Grifoni @profshanecrotty @Dani6020 and colleagues. 👇🏼 high degree of T cell preservation against #COVID19 #variants in vaccinated individuals. So even though people freak out about a drop in antibody levels, don’t forget we have T cells!

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Antonio Bertoletti

@Anto_Berto

3 years

Dear SG MOH. Dear Strait times . Covid-19 means Corona- Virus Disease. There aren’t more than 1000 Covid 19 infections daily because you cannot be infected by a disease. You are infected by a virus ( SARS- CoV-2). Why we don’t re- start from some basic.

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Antonio Bertoletti

@Anto_Berto

3 years

Happy to see and share the new that some of our old work will be soon tested in a controlled clinical trial⁩ . Lion TCR Receives FDA Fast Track Designation for its HBV-specific TCR T Cell Therapy.

Lion TCR Receives FDA Fast Track Designation for its HBV-specific TCR T Cell Therapy for Hepatoce...

/PRNewswire/ -- Lion TCR Pte Ltd today announced that it has received Fast Track Designation from United States Food and Drug Administration (U.S. FDA) for...

www.prnewswire.com

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Antonio Bertoletti

@Anto_Berto

2 years

Great work as usual. Demonstration of “ antigenic sin” . However the weaker T cells response only for S1 , infection expand the T cell repertoire towards other SARS2 proteins. I am still thinking hybrid immunity( vac+ inf) increases chances to control. Would love to discuss.

Danny Altmann

@Daltmann10

2 years

New paper in @ScienceMagazine with @BoytonRosemary about Ab and T cells coming into #Omicron and following Omicron breakthrough Keypoint: Omicron infection a rather weak stimulator of Omicron immunity

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Antonio Bertoletti

@Anto_Berto

3 years

Moriremo di gradualita’. Ma non abbiamo ancora capito che se sei vaccinato Omicron e’ meno di un influenza.. Poi continuiamo a fare i tamponi in farmacia con bolli vari.. Il test e’ così’ complesso e poi dai ci vuole qualche bollo. 🤷🏻‍♂️

Locatelli: «La fase critica sta finendo, ora riaprire con gradualità»

Il coordinatore del Comitato tecnico scientifico: no all’ipotesi di accorciare la quarantena degli asintomatici. Il racconto dei momenti più duri in due anni di pareri

www.corriere.it

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Antonio Bertoletti

@Anto_Berto

4 years

Difficult to say. Data told us that in Singapore a SARS2 variant with ORF8 deletion was associated with mild disease. In addition historical data in the 2003 SARS pandemic found that the SARS virus lost ORF8 and became less pathogenic( associated with less severe disease.

CapeWineTours

@CapeWineTours

4 years

@CarolDenyer @Co_Immunity_ @Anto_Berto So does it make the virus less leathal but easier to transmit?

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Antonio Bertoletti

@Anto_Berto

3 years

Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics | Journal of Experimental Medicine | ..it is all about coordination and speed of immunity. Nice work

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Antonio Bertoletti

@Anto_Berto

10 months

@fitterhappierAJ Merry Christmas🤡Still around predicting apocalypse.. come on get a rest..you can reopen the 🎪in 2024.

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Antonio Bertoletti

@Anto_Berto

3 years

Omicron. Let’s see whether is more or less pathogenic and if it infects equally vaccinated/unvaccinated. Info ( not controlled) is that most infected people are unvaccinated. In any case, this shows how limited is the strategy to exclusively rely on Spike for the vaccine.

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Antonio Bertoletti

@Anto_Berto

2 years

Very interesting work of @ShamezLadhani and colleagues. Kids with Spike-T cells but without antibody protected from Omicron Infection( I suppose symptomatic). One other evidence despite small sample size that immunity is not only antibodies. We evolved to have both. Go T cells

Bertoletti Lab

@bertoletti_lab

2 years

Interesting study showing that Spike-T cells associate with protection from Omicron infection in children (4-11 years old). The limitation is the small cohort size, but the data are quite impressive: go T cells! via @JAMAPediatrics part of @JAMANetwork

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Antonio Bertoletti

@Anto_Berto

3 years

Pediatric COVID-19 patients in Brazil. Better innate and adaptive immunity in kids than adults. NP-CD8 T cells higher and Low Spike specific T cells. Other robust evidences that immunity to Spike is not the only one protecting from disease. Nice work!

Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral...

Nature Communications - Children often show milder COVID-19 symptoms, but the underlying mechanistic insights are still lacking. Here the authors profile both pediatric and adult cohorts of...

www.nature.com

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Antonio Bertoletti

@Anto_Berto

9 months

@fitterhappierAJ No my dear🤡. SARS-CoV2 does not elicit a uncoordinated and dysregulated immune response in the all infected individuals. This can occur in the individuals with severe disease and like this paper show in the few individuals with Long-C( if activation is dysregulation..)

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Antonio Bertoletti

@Anto_Berto

5 years

But SARS specific T cells still present in patients with SARS after 11 years(see Ng et so Vaccine 2016:91, 1814.) . Anti viral immunity is also T cells!

The Menachery Lab

@TheMenacheryLab

5 years

Let’s talk immunity to #COVID19 . I am on record saying immunity may only last 1-2 years based on serum neutralizing antibody (Ab) to MERS and common cold CoVs. Does this mean we could go through this again in a few years? That I am less sure of.

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Antonio Bertoletti

@Anto_Berto

11 months

B) Hybrid immunity means that you expand your repertoire of T and B cells. Since the study analyse only Spike , hybrid immunity was not tested. SARs2 does not have a single protein . Try to increase your knowledge of antiviral Immunity before making this interpretations.

Rajeev Jayadevan

@RajeevJayadevan

11 months

Although done in older adults, the study challenges the existing dogma that hybrid immunity is the way out of the pandemic. More infections do not mean better immunity. ❗️The study also shows that time since last dose of vaccine did not affect infection risk. 5/5

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Antonio Bertoletti

@Anto_Berto

4 years

Nice work. In Asia we found cross- reactivity (CR)in about 40% of uninfected individuals . However differently than others who found mainly Spike specific CR, we tested NP and ORF7/8/12 response. We should study better these differences.

Susanna Dunachie

@Susannajd

4 years

Proud that our work on how choice of T cell assay impacts on what SARS-CoV2 responses we see is finally published - big up to all authors & funders @aneogbe @EleanorBarnesOx @LanceTurtle @JohnFrater5 @skellydonal @bonytown @DHSCgovuk @OxfordBRC @UKCICstudy

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Antonio Bertoletti

@Anto_Berto

2 years

@fitterhappierAJ A single figure showing co-localization of SARS-CoV-2 antigen and CD8 in a biopsy is not a demonstration that a virus is infecting and replicating in T cells. Science is a serious work. Please

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Antonio Bertoletti

@Anto_Berto

2 years

@ana_berne We cannot take a single extreme case and decide that this what is occurring in everyone. Yes, we should study better the effect of SARS-2 infection, but without this constant spin of terror and human race extinction. But I had COVID, free to say my cognitive ability is reduced😜

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Antonio Bertoletti

@Anto_Berto

3 years

@Daltmann10 Thinking on the same direction but if you look at the data carefully there is a 10% of individuals with T cells completely unable to recognise the mutations. In addition in almost all individuals there is a 10-15% decrease on global T cell recognition. Story not finished here.

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