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Nature Immunology

@NatImmunol

2 years

The explosion of single-cell and systems approaches in immunology risks leaving the uninitiated behind. Bonaguro et al provide a guide to #Systems_immunology that is designed for immunologists who want an introduction to the area. DOI:10.1038/s41590-022-01309-9

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Nature Immunology

@NatImmunol

3 years

Neutrophils guide pre-existing matrix into injured organs to initiate tissue repair. News and Views by Ng.

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Nature Immunology

@NatImmunol

3 years

Epithelial cells use an immune-like mechanism to extrude and kill neighboring precancerous cells. Maruyama and colleagues demonstrate that LILRB3 on normal epithelial cells recognizes elevated Class I on transformed cells and triggers the extrusion process.

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Nature Immunology

@NatImmunol

1 year

In this resource Streets and colleagues provide a timeline of CD4+ and CD8+ T cell lineage commitment, identifying sequential waves of TCR signaling that initiate CD4+ T cell then CD8+ T cells lineage differentiation. Read it here:

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Nature Immunology

@NatImmunol

2 years

A multiomic atlas of T cell exhaustion in chronic viral infection reveals molecular programs of exhausted T cell subsets, divergent clonal exhausted T cell differentiation trajectories and suggests TCR signal strength as a driver of clonal fate

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Nature Immunology

@NatImmunol

3 years

Haas and colleagues use single cell multi-omics of human blood and bone marrow to generate a reference map allowing the quantitative linking of cytometry and proteo-genomic information.

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Nature Immunology

@NatImmunol

4 years

Review: The immunology of rheumatoid arthritis

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Nature Immunology

@NatImmunol

3 years

SARS-CoV-2 infection is milder in children. Dowell et al. show that immune responses are higher in children, retained for 12 months or longer and can neutralize Alpha, Beta and Delta variants. & see the Research Briefing

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Nature Immunology

@NatImmunol

4 years

Helper T cell subsets are characterized functionally by the cytokines they produce. Benoist and colleagues demonstrate that in vivo helper T cells do not manifest as discrete helper subsets but rather form a continuum shaped by microbial exposure

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Nature Immunology

@NatImmunol

2 years

Dubrot et al use genome-scale in vivo CRISPR screens to look at #immune_evasion mechanisms across #cancer models, showing that IFN-mediated upregulation of classical and non-classical MHC class I inhibitory checkpoints facilitate immune escape.

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Nature Immunology

@NatImmunol

3 months

Casali and colleagues describe a mouse model with a human lymphoid and myeloid immune system, that expresses BCR and TCR repertories as diverse as humans and mounts antibody responses to infection and vaccination. Read it here:

A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody...

Nature Immunology - Humanized mice have been a valuable tool for modeling human immunology but are limited in their ability to model human antibody responses. Here the authors present their THX...

www.nature.com

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Nature Immunology

@NatImmunol

3 years

Blacher et al find aging disrupts the myeloid circadian clock and identify KLF4 as a critical oscillating transcription factor that regulates macrophage gene expression and phagocytosis. @EranBlacher @StanfordMed

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Nature Immunology

@NatImmunol

2 years

New review: The transcription factor TCF-1 has multiple roles during T cell development and in mature T cells. Gounari and Khazaie review the potential mechanisms by which TCF-1 regulates gene expression

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Nature Immunology

@NatImmunol

5 years

Congratulations to Max Cooper and Jacques Miller for being awarded the Lasker award for the discovery of B and T cells!

Lasker Awards honor scientists for cancer therapy, immune system work

Five scientists have won prestigious Lasker Awards for creating an innovative breast cancer treatment and discovering key players of the disease-fighting immune system.

www.statnews.com

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Nature Immunology

@NatImmunol

4 years

T cell exhaustion limits antitumor immune responses. Vignali and colleagues identify neuropilin-1 as a novel immune checkpoint that cell-intrinsically operates to limit memory cell formation and can be targeted to enhance antitumor responses.

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Nature Immunology

@NatImmunol

2 years

News and Views: LAG3 interferes with TCR signaling by lowering the pH in the vicinity of the TCR and inducing dissociation of the key signaling kinase Lck from the co-receptors CD8 and CD4

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Nature Immunology

@NatImmunol

5 years

The gut microbiota and their proximate immune cells engage in a dialog of reciprocal regulation. James and colleagues describe how immune cell and microbiotal populations vary along the length of the human colon.

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Nature Immunology

@NatImmunol

7 years

New resource paper by Albert and colleagues looking at variability of human immunity

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Nature Immunology

@NatImmunol

6 years

Congratulations to Jim Allison and Tasuku Honjo!!!

The Nobel Prize

@NobelPrize

6 years

BREAKING NEWS The 2018 #NobelPrize in Physiology or Medicine has been awarded jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation.”

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Nature Immunology

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1 year

Philip and colleagues find that tumor-specific CD8+ T cells exhibit epigenetic modifications within hours of activation, before cell division. Continued antigen exposure drove further epigenetic remodeling. Read it here:

Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before...

Nature Immunology - Rudloff et al. examine the kinetics of CD8+ T cell dysfunction/exhaustion. Tumor-specific CD8+ T cells in the tumor environment exhibit epigenetic modifications within hours,...

www.nature.com

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Nature Immunology

@NatImmunol

4 years

SARS-CoV-2 DNA Endonuclease-Targeted CRISPR Trans Reporter (DETECTR) is rapid CRISPR-based diagnostic tool for the detection of SARS-CoV-2. Results in about 45 minutes with comparable accuracy to that of conventional RT-PCR testing. @cychiu98 @UCSF

Nature Biotechnology

@NatureBiotech

4 years

CRISPR–Cas12-based detection of SARS-CoV-2

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Nature Immunology

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3 years

The degree of plasticity in the epigenetic landscape of exhausted T cells has been unclear. Sen and colleagues find that exhausted CD8 T cells have a stable core epigenetic exhaustion signature that persists independent of inflammation or viral antigen.

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Nature Immunology

@NatImmunol

4 years

A time to be thankful. Although 2020 has been a difficult year, we thank the global #immunology community for the tremendous cooperation and collaboration to speed the development of vaccines against the SARS-CoV-2 virus and therapies for #COVID -19 patients.

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Nature Immunology

@NatImmunol

4 years

The contribution of T cells to the SARS-CoV-2 response remains an important and unresolved question. Moss and colleagues examine T cell and antibody kinetics in a large cohort of patients with COVID-19 and find robust and durable T cell responses

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Nature Immunology

@NatImmunol

3 years

B cells regulate hematopoietic stem cells via cholinergic signaling. News and Views by Patel and Pietras

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Nature Immunology

@NatImmunol

3 years

Christo etal find that the tissue in which tissue-resident memory T cells are generated dictates their properties and defines the TRM-cell-intrinsic sensitivity to signaling via the cytokine TGFβ. See also the N&V by McNamara & Cockburn. @LMackayLab

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Nature Immunology

@NatImmunol

2 years

Liston and colleagues design a gene-delivery system to specifically target astrocytes in the central nervous system to express IL-2 and thereby expand/maintain Treg cells to suppress neuroinflammation

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Nature Immunology

@NatImmunol

2 years

#Neutrophils can exhibit substantial function diversity. Montaldo et al @OstuniLab perform immunophenotyping and transcriptome analysis to characterize the heterogeneity of human neutrophils, both under steady state and upon stress-induced conditions.

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Nature Immunology

@NatImmunol

4 years

#immunometabolism see dates Time: 11am EST/5pmCET

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4 years

CD4+ T cells predominate the memory response in patients with COVID-19 severe disease, whereas higher proportions of CD8+ T cells were found in patients with mild disease.

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4 years

New review: Smyth and colleagues provide an overview of recent advances in NK cell biology and discuss the progress and problems of NK cell–based cancer immunotherapies.

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Nature Immunology

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3 years

Arlene Sharpe and colleagues review salient aspects of CD8 T cell dysfunction, with a view of developing new ways to alleviate T cell exhaustion and enhance CD8 T cell functions in #cancer & #chronic_infection . @harvardmed 10.1038/s41590-021-00949-7

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3 years

Ma et al describe TetTCR-SeqHD - a method to simultaneously profile TCR sequences, cognate antigen specificities, targeted gene-expression, and surface-protein expression from tens of thousands of single cells.

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Nature Immunology

@NatImmunol

3 years

Wang et al show that the mTORC2-Akt pathway is needed to maintain CD4⁺ memory cells. This axis suppresses mitoROS generation and subsequent oxidation of membrane phospholipids, preventing cell death by ferroptosis.

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Nature Immunology

@NatImmunol

2 years

How fibrosis and inflammation are integrated is not entirely clear. Susztak and colleagues show that profibrotic proximal tubular cells in the kidneys recruit basophils and activate them to produce interleukin-6 and drive TH17 cell responses

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Nature Immunology

@NatImmunol

3 years

O’Sullivan and colleagues generate a comprehensive single-cell atlas of of human white adipose tissue to identify new cell states in health and obesity.

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@NatImmunol

3 years

#macrophages Chromatin undergoes extensive reprogramming during immune cell differentiation. Kuo and colleagues uncover an epigenetic mechanism that primes the chromatin to facilitate macrophage development

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@NatImmunol

4 years

Mucida and colleagues examine how the gut epithelial microenvironment alters CD4+ T cells during their conversion into intraepithelial lymphocytes. Chromatin accessibility and transcription changes triggered by ThPOK downregulation is required

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Nature Immunology

@NatImmunol

3 years

How microglia sense amyloid plaques in AD is not clear. Lemke and colleagues report that TAM receptor kinases are required for normal microglial recognition of, response to and phagocytosis of Aβ plaques promoting the formation of dense-core plaques.

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@NatImmunol

3 years

Nahrendorf and colleagues show that B cells in the bone marrow are an important source of acetylcholine, which limits hematopoiesis through modulating the signals produced by the bone marrow stromal niche

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Nature Immunology

@NatImmunol

3 years

Joanna Groom points out in her Nature Immunology WorldView that it is time to rethink who and how we mentor. #Mentorship @WEHI_research @groomlab

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@NatImmunol

2 years

Sixt and colleagues show that different fibroblast populations in the lymph node mechanically control its swelling in a multitier fashion. See:

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Nature Immunology

@NatImmunol

3 years

FOXP3 deficiency dysregulates immune homeostasis. This multicenter collaboration finds FOXP3 deficiency only disrupts a few core genes, but this unmasks a degree of systemic inflammation, and it is this environment that then strongly perturbs Tregs

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Nature Immunology

@NatImmunol

5 years

@NatImmunol celebrates #WomensHistoryMonth by highlighting the contributions of women in immunology with specially commissioned content from women across the globe. #WomenInScience @4womeninscience Check out our March issue .

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3 years

Brown and colleagues generated an atlas of miRNA expression profiles from mouse immune cells and connected these signatures with ATAC-seq, ChIP-seq and nascent RNA profiling. @Brown_lab1

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Nature Immunology

@NatImmunol

1 year

Kedzierska and colleagues performed single-cell transcriptomic and paired TCRαβ analyses to map epitope-specific CD8+ T cell immunity across the human lifespan ex vivo in newborns, children, adults and older adults. Read it here:

Newborn and child-like molecular signatures in older adults stem from TCR shifts across human...

Nature Immunology - Here the authors use single cell profiling of T cells across the human lifespan to show that a suboptimal TCR shift in T cells as we enter older age results in a molecular...

www.nature.com

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@NatImmunol

11 months

Luster and colleagues find that ST2+ Tregs can secrete IL-1Ra in response to IL-33 which reduces early IL-1-mediated innate immune responses during influenza infection. Read it here:

Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection

Nature Immunology - Luster and colleagues report that lung-resident ST2+ regulatory T cells secrete the IL-1 antagonist IL-1Ra to suppress neutrophils and early innate immune responses to influenza...

www.nature.com

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Nature Immunology

@NatImmunol

2 years

Bresser et al designed a reporter system to allow in vivo tracking of replicative history over many generations. They show stem-cell-like memory T cell pool that reconstitutes the CD8+ T cell effector pool upon reinfection is marked by prior quiescence

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Nature Immunology

@NatImmunol

4 years

July 2020 marks the 20th anniversary of Nature Immunology's launch. To celebrate, we have commissioned a series of Comments from some of our authors from the last 20 years describing their landmark studies and how they drove immunology research forward.

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Nature Immunology

@NatImmunol

8 months

Siliciano and colleagues describe the generation of bispecific antibodies that target HIV-1 and NK cells to enhance HIV-1-specific NK cell activity and reduce the viral reservoir. Read it here:

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Nature Immunology

@NatImmunol

3 years

The innate sensors of SARS-CoV-2 are still being determined. Kanneganti & colleagues find that the SARS-CoV-2 envelop protein is sensed by TLR2 and this drives pathogenic inflammatory cytokine production. #COVID19

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@NatImmunol

5 years

Masopust and colleagues @Masopust_Vezys show that tissue-resident memory cells can reenter the circulation, and exhibit considerable plasticity, although they retain a proclivity to reestablish themselves in their tissue of origin.

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Nature Immunology

@NatImmunol

3 years

The British Society of Immunology has just launched a COVID vaccine hub. Stuffed with info. for the general public, educators, researchers and policy makers - check it out:

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@NatImmunol

3 years

Tumor-associated macrophages (TAMs) support an immunosuppressive tumor microenvironment. Di Conza et al. uncover how ER stress responses pathways are engaged to orchestrate pro-tumorigenic features and survival in TAMs by tumor-derived lipids. @PCHo_Lab

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Nature Immunology

@NatImmunol

2 years

Vignali and colleagues report CD8+ T cells in the pancreatic islets have a LAG3-promoted ‘restrained’ phenotype resembling exhausted cells but maintain effector functions, and LAG3 expression limits pathology in the NOD mouse model of type 1 diabetes

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Nature Immunology

@NatImmunol

4 years

Good opportunity for students around the globe.

Elina I. Zúñiga

@ZunigaLab

4 years

Together with my friend Carla Rothlin we are launching Global Immunotalks 2020 #globalimmuno To be held Wednesdays 9 am PST starting 4/22 ZOOM: Schedule at Hoping to benefit #immunology community globally Please pass the word!

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4 years

Glioblastoma is one of the most intractable tumors and presents a hypoxic and immunologically cold microenvironment. Lee and colleagues demonstrate that normalizing oxygen tension unleashes γδ T cell anti-glioblastoma function

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Nature Immunology

@NatImmunol

3 years

Wu et al report that T cells from patients with rheumatoid arthritis, mitochondrial aspartate is deficient, resulting in ER expansion and excessive production of the pro-inflammatory cytokine TNF. See also the N&V by Scherlinger & Tsokos

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Nature Immunology

@NatImmunol

5 years

Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells| Lan Wu et al & Nabel lab | #Tumorimmunology #cancerimmunotherapy First publication in @NatureCancer N&V by Garfall & June @carlhjune

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Nature Immunology

@NatImmunol

8 months

Shlomchik and colleagues profile memory B cell subsets and their precursors to describe differences in genes and open chromatin regions. Read it here:

Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted...

Nature Immunology - Callahan et al. show that GC and extra-GC sites spawn distinct MBC subsets. MBC precursors have open chromatin regions (OCRs) that will remain open in MBC progeny, with extra-GC...

www.nature.com

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Nature Immunology

@NatImmunol

3 months

Vivier and colleagues integrated scRNA-seq and CITE-seq data to provide a resource of human NK cell heterogeneity in healthy tissues and in the tumor setting. Read it here:

High-dimensional single-cell analysis of human natural killer cell heterogeneity

Nature Immunology - Single-cell technologies have unveiled a complex understanding of NK cells that has led to variations in nomenclature and inconsistencies across the scientific literature. Here,...

www.nature.com

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Nature Immunology

@NatImmunol

1 year

Rudensky and colleagues find that Treg depletion in a PD-1 resistant cancer model vastly alters the TME and Treg dependent programs were identified, such as the VEGF pathway. Treg depletion and VEGF blockade improved tumor control

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Nature Immunology

@NatImmunol

4 years

Browse the Nature Collection on Stromal–Immune Cell interactions - now live at #Lymph_nodes #fibroblasts #mesenchymal_cells #inflammation #cancer @NatImmunol @NatRevImmunol @Boehringer

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3 years

In their Perspective, Becher and colleagues propose an alternative framework in which to understand T helper diversity, based not on transcription factors and cytokines but rather physiological functionality. @burkhard_becher

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Nature Immunology

@NatImmunol

9 months

Chen and colleagues define the stem-like program that controls the self-renewal capacity and effector differentiation potential of CD4+ effector precursor cells. Read it here:

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@NatImmunol

11 months

Minguet and colleagues find that CAR T cells containing CD3δ, CD3ε or CD3γ cytoplasmic tails are more effective than conventional ζ CAR T cells. Read it here:

Harnessing CD3 diversity to optimize CAR T cells

Nature Immunology - Minguet and colleagues systematically examine how individual CD3 chains of the TCR–CD3 complex can improve chimeric antigen receptor (CAR) T cell performance.

www.nature.com

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@NatImmunol

3 years

George Gao and colleagues designed a Zika virus vaccine that induces sterilizing immunity and fetal protection in mice challenged with ZIKV & that does not induce antibody-dependent enhancement on subsequent Dengue virus infection.

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Nature Immunology

@NatImmunol

4 months

Shlomchik and colleagues find that IL-12 initiates a B cell-intrinsic feed-forward loop between IL-12 and IFNγ which promotes B cell proliferation and plasmablast differentiation. Read it here:

IL-12 induces a B cell-intrinsic IL-12/IFNγ feed-forward loop promoting extrafollicular B cell...

Nature Immunology - Shlomchik and colleagues uncover a positive feedback loop between interleukin-12 and interferon-γ, which promotes extrafollicular plasmablast differentiation and suppresses...

www.nature.com

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Nature Immunology

@NatImmunol

2 years

Perry et al. demonstrate that regulatory T (Treg) cell function is restrained by the cell-autonomous action of the checkpoint inhibitor molecule PD-1. This PD-1-dependent mechanism tunes Treg cell function during homeostasis and infection

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@NatImmunol

3 years

Andreakos discusses in @NatImmunol two new studies on how #SARS_CoV_2 infection triggers type I IFN-mediated immunopathology @VangelisAndrea1

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2 years

New review: Godbout and colleagues discuss the neuroimmune mechanisms that underlie social-stress defeat, anxiety, and post-traumatic stress disorder .

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@NatImmunol

9 months

Chevrier and colleagues mapped the response to sepsis and describe a hierarchical cytokine module composed of TNF, IL-18, IFN-γ and IL-1β responsible for shaping the host response. Read it here:

A pairwise cytokine code explains the organism-wide response to sepsis

Nature Immunology - Chevrier and colleagues uncovered a hierarchical cytokine circuit arising from the pairwise effects of TNF with IL-18, IFN-γ or IL-1β, which explains the organism-wide...

www.nature.com

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@NatImmunol

3 years

Thomas Korn and colleagues show skin and gut imprinted helper T cell subsets exhibit distinct function phenotypes in central nervous system autoimmunity. @TU_Muenchen

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1 year

Chi and colleagues identify brain-resident CXCR6+PD-1+CD8+ T cells that interact with microglia to limit immune-mediated pathology in a mouse model of Alzheimer’s disease. Read it here:

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology

Nature Immunology - Chi and colleagues identify brain-resident CXCR6+PD-1+CD8+ T cells that interact with resident microglia to limit immune-mediated pathology in a mouse model of Alzheimer’s...

www.nature.com

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@NatImmunol

3 years

New Resource! Sumida et al. resolve the human T cell transcriptional response to type IFN stimulation at high temporal resolution and reveal a genetic network controlling coinhibitory receptor expression

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@NatImmunol

3 months

Klein and colleagues find that SARS-CoV-2 infection results in IL-1β-mediated hippocampal dysfunction leading to memory defects, which can be prevented by vaccination. Read it here:

Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice

Nature Immunology - SARS-CoV-2 has been shown to induce IL-1β-mediated neuroinflammation in humans and rodent models. Klein and colleagues show that low-dose COVID-19 vaccination prevents...

www.nature.com

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@NatImmunol

2 years

Vignali and colleagues show that the inhibitory receptor LAG3 interferes with TCR signaling and T cell activation by lowering the pH at the immune synapse, which causes the dissociation of Lck from the CD4 or CD8 co-receptor

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@NatImmunol

3 years

Chronic viral infection leads to a dysregulation of germinal center B cell responses. Di Pietro et al show deletion of BMI-1 in mature B cells promotes effective humoral responses to chronic viral infection and accelerates viral clearance. @KimLJacobson

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2 years

To determine how T cell lineage fates are determined in the thymus, Singer and colleagues generated ‘FlipFlop’ mice with a functionally reversed T cell immune system that distinguishes TCR signal strength versus TCR signal duration

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3 years

Snell et al. examine the heterogeneity of CD4+ T cells in chronic viral infection, showing PD-L1 blockade enhances a cytotoxic gene program in antigen-specific TH1 cells. @brooks_lab @SnellLaura @pmcancercentre @uhn

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5 years

Sewell and colleagues show nonclassical MHC molecule MR1 is expressed on a wide variety of cancer types and can be targeted by conventional T cells.

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4 years

SARS-CoV-2-specific CD4+ and CD8+ T cell epitopes are found in both convalescent patients and virus-naive volunteers and are indicative of heterologous recognition shared with seasonal cold viruses. @JulianeWalz

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3 years

Liston et al review the diversity of the human immune system, which provides a potent defense against opportunistic pathogens. They discuss the key drivers and pathways in the causality of immune variation.

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2 years

Sansom & colleagues highlight the pH-dependent differential manner in which CTLA-4 binds CD80 and CD86 in Treg cells and orchestrates immune tolerance regulation. See also the N&V by Humphries & Lo.

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@NatImmunol

4 years

Darcy, Beavis and colleagues use T cells engineered to express the dendritic cell growth factor Flt3L to co-opt the host endogenous adaptive immune response and control experimental tumor models. @unimelb @MacCullumCC @WEHI_research

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2 years

Yu et al. review the roles played by follicular helper T cells in sustaining germinal center B cell responses and vaccination strategies, as well as potential pathogenic autoimmune responses. See

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2 years

David Brooks and co. () use mass cytometry to look at pre-existing T cell responses to type 1 interferon to predict patient survival and responsiveness to ICB therapy. For commentary see our News and Views:

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4 years

Calling attention to the upcoming #BlackInImmunoWeek November 22-28. See @BlackInImmuno for more information on the virtual events planned throughout the week.

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4 years

The transcription factor IRF8 is required for both DC and monocyte differentiation from common myeloid progenitors. Tamura and colleagues identify an enhancer (+56 kb) in the Irf8 locus that regulates early myeloid lineage choice

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4 years

In these strange times- happy World Immunology Day everyone:

2020 International Day of Immunology » IUIS

The International Day of Immunology is just around the corner on April 29, 2020! The day is dedicated to increasing global awareness of the importance of immunology in the fight against infection…

iuis.org

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5 years

Obit: Vincenzo Cerundolo 1959–2020

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1 year

McGavern and colleagues find that monocytes produce IL-6 which instructs microglia to become repair associated microglia following intracerebral hemorrhage, which promotes neurological recovery. Read it here:

Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature

Nature Immunology - Choi et al. show that infiltrating CCR2+ monocytes, by provision of IL-6, instruct tissue-resident microglia to become ‘repair-associated microglia’ following...

www.nature.com

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@NatImmunol

1 year

Akassoglou and colleagues provide a resource of the responses of microglia and macrophages to blood proteins including activated complement and fibrin. Read it here:

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Nature Immunology - Akassoglou and colleagues provide a single-cell RNA sequencing and phosphoprotein analysis of the responses of central nervous system microglia and macrophages to blood proteins...

www.nature.com

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3 years

See our special issue on the immunology of COVID-19:

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5 years

Diversity matters. See the Comment by #AkikoIwasaki @VirusesImmunity in the September issue of Nature Immunology. #DiversityAndInclusion

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7 years

New review describing the multiple pathways to autoimmunity

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6 months

Guo and colleagues describe a method for predicting and evaluating drugs to boost immune checkpoint blockade and find Taltirelin can improve anti-PD-1 efficacy by activating CD8+ T cells and DCs. Read it here:

A method for predicting drugs that can boost the efficacy of immune checkpoint blockade

Nature Immunology - Here the authors present a method they call CM-Drug for the identification of combination drugs that can boost the efficacy of immune checkpoint blockade therapy. They validate...

www.nature.com

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@NatImmunol

5 years

NK cells contribute to the destruction of tumors. Wei and colleagues demonstrate that NK cells within the tumor microenvironment undergo mitochondrial fragmentation leading to impairment of their function and survival.

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Nature Immunology

@NatImmunol

3 years

Sun and colleagues provide a new resource, multi-omics analysis of NK cell Jak–STAT signaling in response to the cytokines IL-2, IL-15, IL-12, IL-18 and IFN-α, showing synergistic and antagonistic interactions that govern NK cell activity.

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@NatImmunol

4 years

IL-2 is a classic T cell growth factor. Huang and colleagues demonstrate, however, that chronic IL-2 stimulation leads to a new exhaustion pathway that impairs antitumor immune responses.

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