JExpMed @JExpMed Twitter profile

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JExpMed

@JExpMed

5 years

. @Steph_JExpMed interviews @VirusesImmunity for the latest People & Ideas #WomenInSTEM

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3 years

Using 3 independent approaches - mouse model, human brain organoid & autopsies of #COVID19 patients, @ericsongg @virusesimmunity team demonstrates evidence of #SARSCoV2 neuroinvasion From our #Neuroscience Collection 2021: #SfN21

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4 years

Using both mouse and human brain tissue, researchers at @YaleMed have discovered that #SARSCoV2 can directly infect the central nervous system and have begun to unravel some of the virus’s effects on brain cells (). Press release:

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Do T cells remember what we eat? Lockhart, @danmucida et al @RockefellerUniv show that physiological exposure to food protein drives CD4+ T cell accumulation, clonal selection, and transcriptional adaptation at the intestinal epithelium. #MucosalImmunology

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9 years

- I cited you. - I know. #scienceamoviequote http://t.co/ZgUHGmAzUc

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2 years

Lim, Lin, @Jun_Young_Hong @RMedzhitov et al suggest that #glucocorticoids , classically considered to be broadly immunosuppressive, have a selective immunostimulatory role in B cells. Part of 2022: The Year in Experimental Medicine

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3 years

. @MojdehShakiba @SchietingerLab @sloan_kettering , @philiplabvandy et al show that TCR signal strength determines T cell differentiation and function in tumors, and that intermediate signaling strengths improve anti-tumor activity in vivo. #TumorImmunology

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4 years

Neurological symptoms are frequently observed in #COVID19 . Using three independent approaches - mouse model, human brain organoid and autopsies of COVID-19 patients, @ericsongg @virusesimmunity team demonstrates evidence of #SARSCoV2 neuroinvasion.

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4 months

NK cells were first described five decades ago and named in 1975. This brief Perspective from Lewis Lanier @UCSF highlights a timeline of a few selected advancements in NK cell biology in each decade. 🎥 See video summary:

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4 years

Neuroinvasion of SARS-CoV-2 in human and mouse brain. Eric Song @ericsongg , Akiko Iwasaki @virusesimmunity and colleagues demonstrate evidence of #SARSCOV2 neuroinvasion. Video shows whole-brain view of SARS-CoV-2 infection in mouse. #COVID19

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2 years

Neutrophil phenotypes and functions in cancer: A consensus statement From @DanielaQuail , @Bristolneutlab @ZviFridlender @AndrsHidalgo16 @IMalanchi @merghout @mittallab @MikaelPittet @UdalovaLab @zychlinsky @megeblad @Kubes_Lab and colleagues

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1 year

So, Obata-Ninomiya et al. show that suppression of CD4 effector T cell activation by Tregs is enforced through active mRNA translational control of the protein synthesis machinery. From our #Immunology collection:

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3 years

This study by @maria_tokuyama , @VirusesImmunity and colleagues shows that antibodies from #lupus patients form immune complexes with endogenous retrovirus envelope protein to stimulate #neutrophil activation and NETosis. #SLE #autoantibodies #autoimmunity

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3 years

#Astrocytes are strategically positioned to control CNS immunity in the context of health & disease. Sanmarco, Polonio, Wheeler, and Quintana ( @QuintanaLabHMS ) review progress in elucidating astrocyte–immune interactions in #MultipleSclerosis

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2 years

Congratulations 🏆 JEM Editor Jonathan Kipnis @jonykipnis for being elected as a new member of the National Academy of Medicine, for his breakthrough discovery of meningeal lymphatic vessels. Read more about @theNAMedicine announcement here:

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2 years

Jaechul Lim, Erica V. Lin, @Jun_Young_Hong , @RMedzhitov et al. @YaleIBIO reveal that #glucocorticoids promote the production of #IgE by rare B cells in the mesenteric lymph nodes in the absence of experimentally administered antigens. #allergies

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2 years

We are thrilled to congratulate Yasmine Belkaid ( @BelkaidLab ) on being appointed President of the Institut Pasteur ( @institutpasteur ). Her work and leadership are an inspiration to the community, and we are grateful to have her as a JEM Editor. More here:

Professor Yasmine Belkaid appointed Institut Pasteur President

On March 29, 2023, Professor Yasmine Belkaid was appointed President of the Institut Pasteur by its Board of Governors for a six-year term. She will take office in January 2024.

www.pasteur.fr

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1 year

In this study, Tanaka et al. provide a general model of how altered TCR signaling evokes autoimmune disease. Part of our #Autoimmunity Collection: #AUTOIMMSRC

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3 years

This study by @tianyangmao et al. @virusesimmunity team shows that RIG-I agonist stem loop RNA (SLR) triggers potent antiviral defense against #SARSCoV2 to prevent primary infection and clear chronic infection. #COVID19 #InfectiousDisease #HostDefense

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9 months

Lockhart, @danmucida et al. show that physiological exposure to food protein drives CD4+ T cell accumulation, clonal selection, and transcriptional adaptation at the intestinal epithelium. From the Year in Experimental Medicine:

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5 years

Congratulations Akiko Iwasaki, JEM Advisory Editorial Board Member, for winning the 2019 Seymour & Vivian Milstein Award for Excellence in Interferon and Cytokine Research. Read more about the prize and Iwasaki's work:

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1 year

Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells. From Lockhart, @danmucida and colleagues: In Microbiota, Diet, Metabolites & the Immune System: #KSMicroImmune24 #KSMetabolites24

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2 years

. @MojdehShakiba , @SchietingerLab et al. show that TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion. From our #Immunology Collection 2022:

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2 years

This review from Renee Wu & Kenneth Murphy @WUSTLImmuno traces the separate discoveries of dendritic cells, cross-priming, and help for cytotoxic T cell responses. #InnateImmunity

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4 years

To coincide with #WHM2021 , Gwen Randolph @LabRandolph shares her observations and hopes for faster progress on promoting the status of women in science. #WomeninSTEM

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8 months

Lockhart, @danmucida et al show that physiological exposure to food protein drives CD4+ T cell accumulation, clonal selection & transcriptional adaptation at the intestinal epithelium In Barrier Immunity collection: #KSBarrierReg24

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2 years

. @RafaelTaeho , @IliaVainchtein , @AnnaMolofskyLab et al. @UCSF define coordinated epigenetic and functional changes in #microglia and uncover pattern recognition receptors as potential regulators of postnatal synaptic refinement. #Neuroscience

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1 year

In this review, Jeltema et al. @nanyanlab discuss STING trafficking mechanisms and implications on immune and neurodegenerative disease. From our collection Innate Immune Cells & Signaling: #KSInnateImmune23

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3 months

History of NK Cell Discoveries. This brief Perspective by Lewis Lanier @UCSF highlights a timeline of a few selected advancements in NK cell biology from a personal perspective of being involved in this quest. 🎥 See video summary:

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2 years

International collaborative team discover that gain-of-function variants in STAT6 explain some cases of severe, early-onset allergic disease: @Turveylab @casanova_lab @dan_leung_ @BeziatV @IsabelleMeyts #allergies #immunodeficiency

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1 year

Lockhart, @danmucida et al @RockefellerUniv demonstrate that exposure to food protein drives an antigen-specific CD4+ T cell response characterized at steady state by accumulation at the intestinal epithelium & tissue-specialized transcriptional imprinting

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9 years

You seem like a nice kid. I would hate to see you end up in the acknowledgements #AcademicNoir

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9 months

Lei, Pereira, @PaderaLab @beyazlab et al. demonstrate that #cancer cell MHC-II expression promotes #metastasis and immune evasion in tumor-draining lymph nodes. From the Year in Experimental Medicine:

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3 years

Viral infection early in life can result in autoimmunity later in life. Tarin M. Bigley, Wayne M. Yokoyama et al. @WUSTLmed show that neonatal murine roseolovirus infection disrupts central tolerance. #Autoimmunity #InfectiousDisease #HostDefense

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10 months

Lund, Hunt, @justZeri et al. @PainLab_KI @karolinskainst show that the blood–DRG barrier is composed of endothelial cells with high permeability and is monitored by a subset of CD163+ perivascular #macrophages , a process that is arteriovenously zonated.

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6 years

JEM Academic Editor Yasmine Belkaid was selected to receive the @FNIH_Org 2019 Lurie Prize in Biomedical Sciences (). Belkaid blazed a trail in understanding the microbiome’s significant role in immune regulation.

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3 years

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion, say @MojdehShakiba , Andrea Schietinger @SchietingerLab @sloan_kettering , @philiplabvandy and colleagues. #SolidTumors #TumorImmunology

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6 months

Tanaka, Sakaguchi et al. provide a general model of how altered TCR signaling evokes autoimmune disease. Part of our collection on Thymus, T Cell Development, and Inborn Errors:

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7 months

Nutrients interplay w/ Signals 1-3 to orchestrate T cell activation, differentiation, & function. New review from Raynor and @hongbo_chi @StJude highlights the signaling and functional effects of nutrients as Signal 4 in T cell–mediated immunity.

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2 years

Boieri, @CaImmunoprevent et al. demonstrate that CD4+ T helper cells directly block #breastcancer development by forcing the cancer cells to terminally differentiate. From our #Cancer #Immunotherapy collection: #SITC22

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1 year

Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells, say Ainsley Lockhart, Daniel Mucida @danmucida and colleagues @RockefellerUniv : #MucosalImmunology #Tolerance

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2 years

Role of adipose tissue macrophages in obesity-related disorders. @SvetoslavChaka1 , Blériot & @FGinhoux detail how obesity transforms both adipose tissue and local macrophage populations #inflammation #Metabolism #InnateImmunity

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3 years

New study of innate immune dynamics in early #COVID19 - host response can slow viral replication from low infectious dose, & block replication if defenses boosted by recent common cold infection. From @EllenFoxman @cnreddy24 @TimothyAWatkins et al @YaleMed

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2 years

Role of adipose tissue macrophages in obesity-related disorders. In this #InnateImmunity focus review, @SvetoslavChaka1 , Blériot & @FGinhoux @sjtu1896 discuss macrophage origin & functions in adipose tissue and how these features are modulated in obesity

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4 years

Dendritic cells: The first step. Gwendalyn Randolph ( @LabRandolph ) discusses the seminal discovery by Steinman in 1973 (), the first in many steps of important work that revealed the nature of #DendriticCells . #JEM125

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4 years

Sticky webs of DNA released from immune cells known as neutrophils may cause much of the tissue damage associated with severe #COVID19 infections, according to 2 new studies ( & ). See press release: #SARSCoV2

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2 years

Sara Suliman @SaraSuliman13 , an assistant professor at @UCSF , uses multiple approaches to identify candidate #tuberculosis risk pathways and to determine their role in #TB progression. Read more about her research in our latest #PeopleAndIdeas :

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1 year

We're thrilled to hear that Akiko Iwasaki ( @VirusesImmunity ), a JEM Advisory Editor, has been elected as the 2023-2024 President of The American Association of Immunologists (AAI) @ImmunologyAAI . Congratulations!! 💐

AAI

@ImmunologyAAI

1 year

AAI is pleased to announce Akiko Iwasaki, Ph.D. (AAI '00), as its 2023–2024 president. Dr. Iwasaki, a distinguished immunologist and esteemed member of the AAI Council, will assume her role as president on July 1, 2023. #AAI #immunology #womeninstem

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4 years

Rodrigues, @ZamboniLab et al. show that #inflammasomes are activated in response to #SARSCoV2 infection in vitro & in #COVID19 patients. #Inflammasome activation in moderate & severe cases of COVID-19 impacts disease progression & clinical outcome.

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11 months

. @Brabec_Tomas_ , @SchwarzerGnoto , @TheAbramsonLab , @FilippLab , @HonzaDobes87 et al. show that segmented filamentous bacteria induce the conversion of cognate CD4+ T cells to cytotoxic intraepithelial lymphocytes. @science_charles #MucosalImmunology

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1 year

Waipan Chan, Ronald Germain et al. @NIAIDNews show that PD-1 engagement by T cells inhibits distinct antigen-evoked signals in a nonlinear manner, strongly influenced by the nature of available TCR ligands. #TumorImmunology #LymphocyteBiology

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7 months

Chan et al. show that PD-1 engagement by T cells inhibits distinct antigen-evoked signals in a nonlinear manner, strongly influenced by the nature of available TCR ligands In our #Cancer #Immunotherapy Update 2024: #KSCheckpoint24

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2 years

Oh, Senger, Madireddi, Haley, Rutz et al. @genentech describe a nonviral method for CRISPR/Cas9-based gene editing of human T cells that could help advance our understanding of T cell biology and aid the development of next-generation cellular therapies

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2 years

Using scRNA-seq and scTCR-seq, Kasmani @MoujtabaK , Zander @Razander @Cui_Lab , Kaech and colleagues identify multiple branching pathways regulating CD8 T cell differentiation during chronic viral infection. #InfectiousDisease #HostDefense

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9 months

Min et al. @FilianoLab @DukeMedSchool show mural cells physically contact #macrophages in the dura to regulate trafficking of CNS antigen-specific T cells. Partially depleting mural cells activates dural macrophages & increases susceptibility to EAE.

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7 months

Ruggiu, Guérin et al. @BoussoLab @institutpasteur demonstrate that anti-PD-1 mAb promotes CD8+ T cell responses in tumor-draining lymph node by targeting Tfh cells and stimulating IL-4 production. #TumorImmunology #immunotherapy

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10 months

. @avayala14 et al. @theChuLab @UCSanDiego reveal that commensal bacteria, such as Bacteroides fragilis, trigger type I IFN and IL-27 in dendritic cells to influence Tregs through IL27RA signaling. #MucosalImmunology #InnateImmunity #Tolerance #microbiome

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9 months

Findings from Ayala @avayala14 , Chu @theChuLab @UCSanDiego and colleagues demonstrate a critical role of commensal-mediated immune #tolerance via tonic type I IFN signaling. #MucosalImmunology #InnateImmunity #inflammation #microbiome

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3 years

Obesity impairs the anti-tumor immune response. @LydiDyck @tcddublin , @lynchielydia @BrighamEndo and colleagues investigated the effects of #obesity on CD8 T cells in mouse models and patients with endometrial #cancer . #Metabolism #TumorImmunology

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5 years

JEM women in STEM: Unique journeys with a common purpose by Anne O’Garra, @BelkaidLab , Arlene Sharpe, @Tcellogic , @Flybyvirus , Emmanuelle Passegué #WomenInSTEM

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4 years

This review by @puneeth_guru , @MarcoRuella et al. @RuellaLab @PennMedicine examines how single-cell RNA sequencing has transformed the understanding of basic #cancer and immune biology in the context of cancer #immunotherapy . #JEMCancerFocus

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4 months

. @LiangWang917847 @ConnorLynchMD @SeanPitroda @AndrasPiffko @KTyyqx @rweichselbaum et al @UChicagoMed @Ludwig_Cancer review the immune response to #radiotherapy -induced anti-tumor effects, & the combination of immune checkpoint blockade w/ radiotherapy

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3 years

In this review, Sanmarco, Polonio, Wheeler, & @QuintanaLabHMS discuss the role of #astrocyte -immune interactions in #MultipleSclerosis and their potential as therapeutic targets. From our #Neuroscience Collection 2021 👉 #SfN21

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1 year

Lei, Pereira, @PaderaLab , @beyazlab et al. reveal that a subpopulation of #BreastCancer cells in the lymph node is marked by MHC-II expression in the absence of costimulatory molecules, which causes the expansion of immunosuppressive regulatory T cells.

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8 months

Qin, Wang, Xu et al. show that TCR signaling induces STAT3 phosphorylation through Lck/Fyn and, synergistically with cytokine signal, induces optimal STAT3 phosphorylation to drive TH17 cell differentiation. #Neuroinflammation

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4 years

Stoler-Barak et al. introduce an approach that enables the visualization of all the germinal center niches and activated B cells within intact lymph nodes. From the special collection on Germinal Centers and Immune Niches:

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8 months

Lund et al. @PainLab_KI show that the blood–DRG barrier is composed of endothelial cells with high permeability and is monitored by a subset of CD163+ perivascular #macrophages . In our #Immunology Update Winter 2024:

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1 year

Combining whole-tissue imaging & single-cell RNA sequencing datasets, Tauber, Basso, Martin et al @InfinityTLS present a pan-organ analysis of mast cells (MCs) in mice & humans at steady state, revealing an unexpected heterogeneity of MC populations

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6 months

The authors describe the clinical features, cellular & molecular mechanisms underlying immune deficiency in 7 patients w/ biallelic germline variants in CD4. This reveals important roles for CD4 in host defense against a range of pathogens, especially HPV.

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10 months

Thru. single-cell transcriptomic analysis, Feng et al @Tsinghua_Uni identified a novel T follicular helper cell subset w/ stem cell–like transcriptional features & long-term survival ability, which gave rise to effector Tfh cells in recall immune responses

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2 years

Schad, Wolchok, Merghoub @MSKCancerCenter and colleagues show that antigen stimulation induces a subset of CD4+ and CD8+ T cells to differentiate into CD4+CD8+ T cell subsets gaining in polyfunctional characteristics within the tumor. #TumorImmunology

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2 years

Walsh and @LukensJohnR @MedicineUVA discuss work in which @JPChadarevian , @Sonia_Lombroso , @BlurtonJonesLab , @FChrisBennett et al () describe a novel strategy that enables improved engraftment of human #microglia .

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9 months

Mural cells interact with #macrophages in the dura mater to regulate CNS immune surveillance, say Hyunjung Min, Anthony Filiano @FilianoLab and colleagues @DukeMedSchool : #Tolerance #Neuroinflammation #Autoimmunity

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1 year

Stensland, Smith and colleagues @CUAnschutz identify an antigen-specific B cell subset that may play a role in the rapid progression of young-onset type 1 diabetes. #Autoimmunity #Tolerance

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3 years

Lopez et al @CHUdeLyon show that #SARSCoV2 induces strong type I IFN immunity in the nasopharyngeal cavity of mildly symptomatic #COVID19 patients, but this response is compromised in critically ill patients w/ autoantibodies against type I IFNs

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1 year

Petersone et al. @LucyWalkerlab @iit_ucl investigate IL-21–dependent germinal center (GC) regulation and reveal key roles for IL-21 in promoting light zone GC B cell selection and controlling dark zone GC B cell proliferation by upregulation of cyclin D3.

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1 year

. @RafaelTaeho , et al. @AnnaMolofskyLab show that microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice From our #Neuroimmunology & #Neurodegeneration collection:

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4 years

In this #OpenAccess perspective, @megeblad , Betsy J. Barnes et al present evidence from autopsy results & the literature supporting the hypothesis that #neutrophil extracellular traps (NETs) may contribute to organ damage and mortality in #COVID19 .

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7 months

Understanding how T cells respond to Signal 4 nutrients in microenvironments will provide insights into context-dependent functions of adaptive immunity and therapeutic interventions. Review from Jana Raynor and Hongbo Chi ( @hongbo_chi ) @StJude :

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4 months

#Radiotherapy and #immunology . A new review from Liangliang Wang ( @LiangWang917847 ), Connor Lynch ( @ConnorLynchMD ), Sean Pitroda ( @SeanPitroda ), Ralph Weichselbaum ( @rweichselbaum ) and colleagues @UChicagoMed : @KTyyqx @AndrasPiffko #CancerFocus

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4 months

A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin #inflammation in mice, say Kelsey Toth, Megan Cooper @MACattackLab and colleagues @WUSTLmed : #Autoimmunity #Immunodeficiency

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3 months

By tracing development of anti-IFN-I autoantibodies in individuals over a 35 year period, @BenHalePhD et al suggest that loss of self-tolerance prior to immune-triggering poses a risk for lifelong autoantibody-mediated functional IFN-I deficiency.

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8 months

DePeaux et al. @DelgoffeLab show that an oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment. From our #Immunology Update Winter 2024:

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5 months

Markus Feuerer's lab @uni_regensburg reveal that human effector CD8 T cells not only mediate cytotoxicity but also promote tissue remodeling. From our #Immunology collection: #AAI2024

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2 years

Jacob, Eichmann, Thomas et al @InstitutCerveau characterize the 3D anatomy of meningeal lymphatic vasculature & associated CSF drainage in mice and humans, revealing conserved lymphatic circuitries in contact with dural venous sinuses

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6 years

. @ADeczk and Schwartz describe how harnessing the immune system in a well-controlled manner can be used as a universal therapeutic approach to neurodegeneration

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3 years

. @elzaevren @WillingerLab et al. identify CD116+ fetal liver cells as precursors of human alveolar #macrophages in early life & determine the impact of cell origin on lung #macrophage identity & function in the human context with a unique in vivo model.

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2 years

. @ZhiLiImmunology @KelvinTuong @IWD_Sci et al use photoconversion to temporally label tumor-infiltrating lymphocytes, revealing the continuous migration of TCF-1+ T cells btwn the tumor & draining lymphoid tissue @LabWithers @ClatworthyLab @Hepworth_Lab

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1 year

Inborn errors of human B cell development, differentiation, and function. A new review from @stutangye , Tina Nguyen, @ElissaDeenick , @vanessabryantoz , and @DrCindyMa @Tangye_Lab : #HumanDiseaseGenetics #Immunodeficiency #LymphocyteBiology

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1 year

New review: @stutangye et al. discuss how the importance of human B cells in host defense against infectious diseases has been established by the discovery of inborn errors of immunity that disrupt B cell development, differentiation or function

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10 months

At JEM this year we have been highlighting #WomenInSTEM in the #PeopleAndIdeas Interview series. We are so thankful to everyone who contributed, and we would like to share some of the highlights below. Be sure to check out the interviews here:

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9 months

. @RawatKSM , @Claudjak et al. show that dendritic cells use the chemokine receptor CCR7, while monocytes follow chemokines secreted by migratory DCs to reach lymph nodes and control immunity. From the Year in Experimental Medicine:

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3 years

Functional immune cell–astrocyte interactions. Sanmarco, Polonio, Wheeler, and Quintana ( @QuintanaLabHMS ) review progress in elucidating #astrocyte –immune interactions in #MultipleSclerosis . #neuroinflammation #autoimmunity

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9 months

. @mikacadiz @johnthefryer et al. show the anti-amyloid #immunotherapy aducanumab triggers microglial/immune activation acutely but discontinuation up to 7 months later impairs microglial activation even with plaque recurrence #microglia #Alzheimers

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@JExpMed

1 year

Tae Sung Kim et al. show that #neutrophil extracellular traps & extracellular #histones potentiate Th17 #inflammation & bone destruction in animal models of #periodontitis . From our #Cytokines Collection: #Cytokines2023

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JExpMed

@JExpMed

1 year

Findings from Chan, Germain et al. @NIAIDNews help resolve discrepancies in existing data about the site(s) of PD-1 inhibition in T cells while emphasizing the importance of neoantigen potency in controlling the effects of checkpoint therapy:

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22

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JExpMed

@JExpMed

1 year

Golnaz Vahedi @golnaz_v @PennMedicine runs a multidisciplinary lab that uses cutting-edge computational and experimental approaches. We talk about her diverse scientific background, the benefits of integrating molecular biology and immunology, & more:

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JExpMed

@JExpMed

5 years

Although many inflammatory diseases share the feature of elevated IL-17 production, therapeutic targeting of IL-17 has vastly different clinical outcomes. This review summarizes recent progress in understanding the IL-23/IL-17 axis in disease #JEMcytokines

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JExpMed

@JExpMed

4 years

. @prokuninaolsson @Lo_Zanzi @drdeannasanter @DickensonRuth and colleagues discuss the benefits and potential limitations of using Interferon Lambda (a type III interferon) to prevent, limit, and treat #COVID19

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JExpMed

@JExpMed

1 year

In this review, @MaizelsLab & Gause summarize how type 2 immune responses combat helminth parasites through novel mechanisms: From our #Cytokines Collection: #Cytokines2023

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23

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