Katerina Akassoglou @AkassoglouLab Twitter profile

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Katerina Akassoglou

2 months

Our new paper is out @Nature We report that fibrin drives toxic inflammation, impaired viral clearance & neuropathology in #SARSCoV2 infection treated by #fibrin antibody #LongCovid #Coagulation #Immunotherapy #fibrinogen #COVID19

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Katerina Akassoglou

@AkassoglouLab

1 year

Our paper was selected for the Cover of @NatImmunol Cover Art of blood in the brain driving neurotoxic microglia responses by the incredibly talented @Ella_Maru

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Katerina Akassoglou

@AkassoglouLab

4 years

Our paper “Microglia Gi-dependent dynamics regulate brain network hyperexcitabilty” is now online @NatureNeuro ! By genetic inhibition of #microglia brain surveillance & directed motility, we found that microglia dynamics prevent hypersynchrony & seizures.

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Katerina Akassoglou

@AkassoglouLab

4 years

Our paper was selected for the Cover of @NatureNeuro Cover Art of microglia dynamics reducing excessive neuronal activity by the incredibly talented @Ella_Maru

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Katerina Akassoglou

@AkassoglouLab

5 years

Our paper "Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation"is now online @NatImmunol ! We developed #Toxseq & report the oxidative stress cell atlas of CNS innate immunity & the discovery of new drugs (1/n) 👇

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Katerina Akassoglou

@AkassoglouLab

1 year

Our paper “Defining blood-induced #microglia functions in neurodegeneration through multiomic profiling” is out @NatImmunol . We report the selectivity of blood microglia gene & signaling networks & causality for specific blood proteins in AD & MS.

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Katerina Akassoglou

@AkassoglouLab

5 years

Our 2020 lab notebook is here! Our annual tradition printing lab notebooks featuring a milestone image. 2016 #astrocyte nuclear pore @NatureNeuro ; 2017 brain vasculature #iDISCO , 2018 2019 Covers @SfNJournals @NeuroCellPress ; 2020 #fibrinogen iDISCO in human AD. Happy New Year!

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Katerina Akassoglou

@AkassoglouLab

3 years

Our 2022 lab notebook is here! Continuing our annual tradition printing lab notebooks featuring a milestone image. This time we simply couldn't choose & featured the beautiful Cover Images of our 2021 papers @NatureNeuro @Brain1878 both designed by @Ella_Maru . Happy New Year!

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Katerina Akassoglou

@AkassoglouLab

3 years

Our paper was selected for the Cover of @Brain1878 Cover Art of blood leaks inhibiting remyelination with therapeutic implications for neurological diseases with BBB disruption & myelin damage by the incredibly talented @Ella_Maru .

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Katerina Akassoglou

@AkassoglouLab

4 years

Today we launched the Gladstone-UCSF Center for Neurovascular Brain Immunology (NBI). Truly grateful to @GladstoneInst @UCSFmac @UCSF for supporting this vision. I look forward to all the amazing basic and clinical research from the NBI scientists and collaborating labs!

Gladstone Institutes

@GladstoneInst

4 years

Katerina Akassoglou will lead the new Gladstone-UCSF Center for Neurovascular Brain Immunology, which brings together a unique combination of expertise to enable novel therapies for #Alzheimer ’s disease and multiple sclerosis ( #MS ) @AkassoglouLab @UCSF

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Katerina Akassoglou

@AkassoglouLab

2 years

Join us for the 2023 @KeystoneSymp #Neuroimmune Interactions I am co-organizing with @wysscoray Nathalie Franchimont held jointly with #Neurodegeneration chaired by @DrLiHueiTsai Aaron Gitler @AzadBonni at beautiful Whistler, Canada May 15-21, 2023!

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Katerina Akassoglou

@AkassoglouLab

1 year

A Research Highlight @NatureNeuro “Blood Proteins Control Microglia” by @ElisaFlo04 elegantly discussing our recent paper by @andrewmendiola et al @NatImmunol Thank you for highlighting our study!

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Katerina Akassoglou

@AkassoglouLab

2 months

Press release “Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy’ by Kelly Quigley @GladstoneInst

Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy

A new study in Nature overturns the prevailing theory that blood clotting is merely a consequence of inflammation in COVID-19.

gladstone.org

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Katerina Akassoglou

@AkassoglouLab

2 months

Our study shows that coagulation serves as an apical driver of infection-induced inflammation and neuropathology, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with Long COVID. Grateful to our funders @NIH @NIH_NINDS @NIHAging @NIAIDNews

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Katerina Akassoglou

@AkassoglouLab

3 years

Our paper "In vivo two-photon microscopy protocol for imaging microglial responses and spine elimination at sites of #fibrinogen deposition in mouse brain" online @STARProtocols . Sharing #OpenAccess in vivo imaging protocols developed @AkassoglouLab (1/7)

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Katerina Akassoglou

@AkassoglouLab

2 months

@quay_dr Thank you Dr. Quay @quay_dr for highlighting our work.

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Katerina Akassoglou

@AkassoglouLab

3 years

I am very honored to be elected to the rank of AAAS Fellow along with amazing colleagues. Grateful to @AAAS for recognizing our scientific contributions in neuroscience & to my lab & collaborators. Congrats to all 2021 elected AAAS Fellows! #AAASFellow

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Katerina Akassoglou

@AkassoglouLab

2 years

It was a great honor to be inducted to the National Academy of Inventors along with extraordinary scientists changing the landscape of engineering & medicine. Such an inspiring celebration of the tremendous impact of academic innovation to benefit society! @AcadofInventors #FNAI

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Katerina Akassoglou

@AkassoglouLab

6 years

Our paper on #fibrinogen in spine elimination & cognitive decline in #AlzheimersDisease is now online @NeuroCellPress ! 3D Volume imaging of BBB leaks in cleared brains from patients with AD. Grateful to our collaborators @GladstoneInst @UCSF @UCSFmac .

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Katerina Akassoglou

@AkassoglouLab

1 year

Fascinating Keynote Lectures by @michelle_monje & Huda Zoghbi on fundamental mechanisms underlying neuroimmune interactions & neurodegeneration @KeystoneSymp Honored to co-chair this session together with @DrLiHueiTsai #KSNeuroimmune23 #KSNeurodegen23

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Katerina Akassoglou

@AkassoglouLab

2 years

I was truly humbled to receive the 2022 ISFP Prize especially as the 1st woman awardee in 48 y since it’s inauguration in 1974. I accepted the Prize on behalf of my lab members & collaborators. Grateful @ISFP_Official community for all the inspiration & support! #NominateWomen

ISFP & PA 2022

@ISFP_PA_2021

2 years

Congratulations to Prof. Katerina Akassoglou @AkassoglouLab for her ISFP 2022 Prize and for her fantastic lecture about fibrinogen and neurovascular interactions! 👏 @ISFP_Official #ISFP2022

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Katerina Akassoglou

@AkassoglouLab

3 years

Our Preview @NeuroCellPress "ApoE & Immunity in AD and related tauopathies: LDLR to the rescue" on the exciting paper by David Holtzman's lab @holtzman4 @WashUNeurology is now online! Fantastic perspective by @andrewmendiola @RTognatta @yan_zhaoqi

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Katerina Akassoglou

@AkassoglouLab

3 years

Truly honored to be named among the Most Influential Women in Bay Area Business! Grateful to my amazing lab & Bay Area ecosystem @GladstoneInst @UCSF supporting research innovation. Thank you @SFBusinessTimes for celebrating women! #WomenInSTEM #SFBTWomen

Meet the Most Influential Women in Bay Area Business class of 2021

These are the inspiring women who made the San Francisco Business Times' annual list of the Most Influential Women in Bay Area Business.

www.bizjournals.com

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Katerina Akassoglou

@AkassoglouLab

1 year

Therini Bio announced $36M financing bringing the total raised to date to $62M for clinical development of #fibrin antibody therapy for Alzheimer’s disease, multiple sclerosis & retinal diseases based on technology developed in my lab @GladstoneInst @UCSF

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Katerina Akassoglou

@AkassoglouLab

5 years

Thrilled! R01 funded to study #neurovascular mechanisms in #Alzheimers disease! Grant will also support our collaborative work with Jorge Palop @GladstoneInst and Mark Ellisman @UCSDMedSchool . Truly grateful to NIA #NIH for supporting our research!

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Katerina Akassoglou

@AkassoglouLab

4 years

Congratulations to Zhaoqi Yan @yan_zhaoqi postdoctoral fellow @AkassoglouLab @GladstoneInst @UCSF for being awarded a @_BrightFocus Alzheimer’s Disease Research Program Award to study #fibrinogen in innate immunity & neuronal dysfunction in AD. So proud of his accomplishment!

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Katerina Akassoglou

@AkassoglouLab

3 years

Exciting paper @Brain1878 on BBB disruption in 22q11.2 deletion syndrome, the most common genetic risk factor in #schizophrenia by @Jorge_I_Alvarez lab @pennvet . Impaired BBB, #fibrinogen extravasation, #astrocyte neuroinflammation in 22qDS+ brains.

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Katerina Akassoglou

@AkassoglouLab

2 years

I am very honored to be selected for the ISFP Prize. Truly grateful @ISFP_Official for recognizing our work on #fibrinogen in brain inflammation & repair and the insight it has brought for therapies for neurological diseases and to my amazing lab, mentors & collaborators!

ISFP

@ISFP_Official

2 years

Announcing the winner of 2022 ISFP Prize! Congratulations to @AkassoglouLab of @GladstoneInst Come and listen to the ISFP Prize Lecture at @ISFP_PA_2021 to be held in Caen, France this Sept! More details at

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Katerina Akassoglou

@AkassoglouLab

2 years

Thank you @Nature for the opportunity to comment in the Research Briefing of the exciting new paper by @ArlottaLab on regional specificity of microglia-neuron interactions.

Neurons shape the identity of microglia in the brain

Nature - Neurons in the brain regulate the number and state of microglia in their local environment.

www.nature.com

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Katerina Akassoglou

@AkassoglouLab

6 months

New paper published today by Terry Dean @terrydeanjr & Andrew Mendiola @andrewmendiola led by Jae Kyu Ryu @JaeKyuRyu shows that #fibrin promotes peripheral monocyte recruitment, oxidative stress and neuronal loss in traumatic brain injury (TBI) via innate immune activation.

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Katerina Akassoglou

@AkassoglouLab

3 years

Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics. New review article by @jrplemel & team discussing toxic microglia activation & #fibrinogen in neurodegeneration in Progressive MS.

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Katerina Akassoglou

@AkassoglouLab

2 years

Join us for the 2023 @KeystoneSymp #Neuroimmune Interactions I am co-organizing w/ @wysscoray held jointly with #Neurodegeneration chaired by @DrLiHueiTsai Aaron Gitler @AzadBonni at beautiful Whistler Canada May 15-20, 2023! Abstracts accepted by April 15

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Katerina Akassoglou

@AkassoglouLab

7 months

Celebrating my 52nd birthday with the lab! The cake was so good it was gone before I could take a photo! Grateful for this amazing team! 🙏🎂🙏

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Katerina Akassoglou

@AkassoglouLab

2 months

Study led by @JaeKyuRyu @yan_zhaoqi Mauricio Montano, Elif Sozmen, Karuna Dixit, Rahul Suryawanshi In collaboration w/ the labs of Warner Greene @TheOttLab @DoctorBou @kristyredhorse @xanderpico @KroganLab Mark Ellisman @GladstoneInst @UCSF @UCLA @UCSanDiego @Stanford @QBI_UCSF

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Katerina Akassoglou

@AkassoglouLab

2 years

Delighted to share the final Program of the 2023 Neuroimmune Interactions @KeystoneSymp joint w/Neurodegeneration I am co-organizing w/ @wysscoray & Dheeraj Malhotra. Join us at beautiful Whistler, Canada May 15-19, 2023! #KSNeuroimmune23

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Katerina Akassoglou

@AkassoglouLab

3 years

Exciting study on #fibrin in periodontitis @ScienceMagazine ! Wonderful validation in neutrophils in oral mucosa of our work on fibrin inducing ROS in macrophages/microglia in the brain, further supporting fibrin as a global activator of innate immunity.

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Katerina Akassoglou

@AkassoglouLab

3 years

This month marks the 25th anniversary of the publication of TNF in astrocytes triggers neurodegeneration microgliosis & BBB disruption. My 1st 1st author paper was a joy, albeit hard to publish in the 90's glia cytokines induce brain pathology🙏 @J_Immunol

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration...

Abstract. To study the involvement of TNF in cerebral pathology in vivo and to define cellular interactions within the central nervous system (CNS) that pr

journals.aai.org

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Katerina Akassoglou

@AkassoglouLab

2 years

Our 2023 lab notebook is here! As this year marks the 20 Year Anniversary of the Akassoglou Lab, we are featuring milestone images to honor 20 years of discovery & innovation by all the incredible scientists who trained & collaborated with the lab. Happy New Year!

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Katerina Akassoglou

@AkassoglouLab

10 months

I recently joined the Advisory Editors @JExpMed It is truly special as the very 1st paper from my lab reporting that #fibrin activates #microglia was published @JExpMed in 2007. It was also our 1st lab Cover. Thank you @Shachi_JExpMed @RockUPress for the invitation & leadership!

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Katerina Akassoglou

@AkassoglouLab

1 year

It was my distinct honor to give the Plenary Alan Giles Memorial Lecture on “ #Fibrinogen in neurodegenerative disease” @isth in Montreal. Grateful to ISTH for selecting our research & to our amazing lab members current and past, our collaborators and funding agencies.

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Katerina Akassoglou

@AkassoglouLab

6 years

Our paper published today @NatImmunol ! We developed a new #immunotherapy to protect against neurodegeneration. Grateful to an international team of collaborators. @GladstoneInst @UCSDMedSchool @UCSF

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Nature Immunology - Fibrin deposition occurs after the blood–brain barrier is breached. Akassoglou and colleagues generate a therapeutic monoclonal antibody that targets a cryptic fibrin...

www.nature.com

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Katerina Akassoglou

@AkassoglouLab

6 years

Delighted to be in Athens to receive the #GreekTopWomenAwards on #InternationalWomansDay . A truly special honor to be presented with the award by European Parliament Member @vozemberg . Thank you @enikolopoulou for your leadership and support for #WomenInSTEM ! @GladstoneInst @UCSF

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Katerina Akassoglou

@AkassoglouLab

4 years

Our 2021 lab notebook is here! Continuing our annual tradition printing lab notebooks featuring a milestone image. 2016 #astrocyte nuclear pore complex; 2017 2020 #fibrinogen vasculature #iDISCO in AD, 2018 2019 Cover images; 2021 #ToxSeq . Looking forward to the New Year!

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Katerina Akassoglou

@AkassoglouLab

1 year

Our Research Briefing " #Fibrin induces neurotoxic #microglia gene programs in neurodegeneration" is now online @NatImmunol ! Grateful to the Editors for giving us the opportunity to discuss the discovery w/ commentary for clinical implications

Fibrin induces neurotoxic microglia gene programs in neurodegeneration

Nature Immunology - Extravasation of blood into the brain and activation of innate immune cells are hallmarks and therapeutic targets in neurological diseases. We show that specific blood proteins...

www.nature.com

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Katerina Akassoglou

@AkassoglouLab

1 year

Excellent review article by Gabrielle de Luca @UniofOxford on vascular contribution to neurological diseases highlighting #fibrin as a common thread in AD, MS and vascular dementia.

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Katerina Akassoglou

@AkassoglouLab

21 days

New Review @CellCellPress by @MichaelPelusoMD & Steven Deeks on #LongCOVID & the path toward therapeutics discussing the role of #fibrin and #coagulation in the pathogenesis of long COVID and their potential as biomarkers & therapeutic targets.

Michael Peluso, MD

@MichaelPelusoMD

22 days

Our mechanistic review of #LongCovid - published in @CellCellPress - hopefully will be helpful coming out of the very inspiring RECOVER-Treating Long COVID meeting this week. Excited for the progress we will make together in the next year!

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Katerina Akassoglou

@AkassoglouLab

4 years

Congratulations to @andrewmendiola for receiving the @GladstoneInst Distinguished Achievement Award in Neuroscience & the Dorman Outstanding Paper Prize for his postdoctoral research in our lab on the oxidative stress innate immune cell atlas @NatImmunol ! So well deserved!

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Katerina Akassoglou

@AkassoglouLab

5 years

Truly honored to be included among the Ten Greeks Who Left Their Mark in 2019. Thank you @GreekReporter for featuring the work of my lab @GladstoneInst @UCSF …

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Katerina Akassoglou

@AkassoglouLab

2 months

@EricTopol @Nature @GladstoneInst Thank you very much Dr. Topol @EricTopol for highlighting our study!

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Katerina Akassoglou

@AkassoglouLab

10 months

Comprehensive and insightful review by @PratLab discussing the role of genes & environment on BBB disruption in MS and the therapeutic implications of mesenchymal stromal cells and antibodies targeting cell adhesion molecules or #fibrin to halt neurodegeneration. @TheLancetNeuro

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Katerina Akassoglou

@AkassoglouLab

8 months

I am truly honored for our research to be selected for the 2024 Pharmacia-ASPET Award "in recognition of work on neurovascular and neuroimmune mechanisms that will have major impact on the treatment of neurological diseases". Grateful to @ASPET and Pharmacia (now @Pfizer ) for

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Katerina Akassoglou

@AkassoglouLab

4 years

Happy Holidays from the @AkassoglouLab ! May our microglia be agile and our neurons in rhythm in 2021!

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Katerina Akassoglou

@AkassoglouLab

2 years

Today marks 15 years for our lab @GladstoneInst @UCSF ! It's been our privilege to be a part of the growing Mission Bay campus transforming biomedical research. Thank you to our amazing team, colleagues & collaborators! 2008 2023

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Katerina Akassoglou

@AkassoglouLab

4 years

New faculty position open at the @UCSF @GladstoneInst Institute of Genomic Immunology. Position open at all levels. Application through this link. Please RT! @MarsonLab @immunox @nationalpostdoc @AWISNational @ImmunologyAAI @BlackInImmuno @ISNI_neuro

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Katerina Akassoglou

@AkassoglouLab

6 months

Excited to speak tomorrow at @ImmunologyAAI International Society for #Neuroimmunology @ISNI_neuro Symposium “Immune cells make you think: Immunity, Brain Function & Disease” w/ @jonykipnis @ErinMGibson & Dorian McGavern. Join us if you are at #AAI24 in Chicago! 🧠🩸💉🧬

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Katerina Akassoglou

@AkassoglouLab

11 months

Excited to speak today at #SfN2023 Symposium “Translation of Blood Brain Barrier Deficits Into Therapeutics for Neurological Diseases” w/Stefano Benvegnu @ARUK_UCL_DDI Martina Pignoti @Roche Katelynn Krick @NeurosciStark @IndianaUniv chaired by @FionaDucotterd Join us! 🧠🩸💉🧬

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Katerina Akassoglou

@AkassoglouLab

4 years

What a great surprise from my amazing lab for my birthday 🎂 today! They are “Team Awesome”, can’t argue with that, and I am so grateful to be a part of it! Can’t wait to celebrate 🎉 🍾 birthdays together again with the lab!

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Katerina Akassoglou

@AkassoglouLab

2 years

The Alzheimer's disease book is out! Our Chapter featured on the Cover shows fibrin (red), blood vessels (green) & amyloid (blue) in human AD brain. Great collection of protocols for human AD from Virginia Lee, Stanley Prusiner, Larry Goldstein & others.

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Katerina Akassoglou

@AkassoglouLab

1 year

Thank you all for joining us @KeystoneSymp & generously sharing your cutting-edge & inspiring research! It was our privilege to organize #KSNeuroimmune23 w/ @wysscoray & Dheeraj Malhotra. We look forward to continue discussions, brainstorming & all new collaborations!

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Katerina Akassoglou

@AkassoglouLab

5 years

Truly honored that the work of our lab was selected for the Rita Levi-Montalcini Neurobiology Keynote Lecture! I look forward to presenting the resent data from our team. Grateful to @ISNI_neuro for supporting our work & for their leadership in #neuroimmunology !

ISNI-The International Society of Neuroimmunology

@ISNI_neuro

5 years

@AkassoglouLab is the the Rita Levi-Montalcini Neurobiology Keynote Speaker at #ISNI 15th International Congress of Neuroimmunology this coming November.

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Katerina Akassoglou

@AkassoglouLab

1 year

Proud to share first-in-human dosing in Phase 1 trial of fibrin-targeting antibody based on technology developed in my lab @GladstoneInst @UCSF , a landmark for #fibrin therapeutics for neurologic diseases & other indications. Congrats to Therini Bio team!

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Katerina Akassoglou

@AkassoglouLab

3 years

Delighted to be elected to the International Advisory Board of the International Society of #Neuroimmunology (ISNI) @ISNI_neuro . Looking forward to serving together with wonderful colleagues around the world & to the 15th ISNI Congress #ISNI2023 in Quebec!

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Katerina Akassoglou

@AkassoglouLab

3 years

We are hiring! The Akassoglou Lab @GladstoneInst @UCSF is expanding its imaging platform. We are looking for an Imaging Research Engineer to join us in San Francisco to lead advanced imaging & software tool development in neuroscience. Please RT! Apply:

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Katerina Akassoglou

@AkassoglouLab

4 years

Congrats to our postdoc scientist @andrewmendiola named 2020 Berkelhammer Scholar! “There are no treatments for cognitive decline” says Mendiola “Understanding mechanisms regulating the brain’s immune system may be key for drug discovery” @GladstoneInst

Young Scientists Committed to Finding Treatments for Neurodegenerative Diseases

The 2020 Berkelhammer Scholars break new ground in research on dementias, Parkinson’s disease, and neuropsychiatric disorders

gladstone.org

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Katerina Akassoglou

@AkassoglouLab

3 years

My dad, born in occupied Greece during WWII, left school at 5th grade. His dream was that I finish high school. He provided me the freedom of unlimited access to education. I am so grateful to him & all fathers who support their daughters unconditionally. #FathersDay #FirstGen

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Katerina Akassoglou

@AkassoglouLab

4 years

Farewell to Mario Merlini who will be starting his lab as an Assistant Professor at the University of Caen! Mario developed brilliant ideas & projects in our lab & I look forward to all the exciting new findings from the Merlini lab! Congrats Mario!!! @GladPostdocs @GladstoneInst

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Katerina Akassoglou

@AkassoglouLab

2 years

Amazing #BIGSymposium22 with such inspiring talks & the best questions and posters from students & trainees. Thank you to the organizers @jonykipnis @TheColonnaLab @holtzman4 for this fantastic meeting at the vibrant #neuroimmunology community @BIG_CenterWashU 🙏

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Katerina Akassoglou

@AkassoglouLab

14 days

Thank you @abc7newsbayarea for raising awareness for Long COVID and @karinanovaabc7 for the fantastic questions and interview.

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Katerina Akassoglou

@AkassoglouLab

3 years

Our Preview @ImmunityCP "Coagulation & Immunity: Caught in the Fibrin Web" is now online! Fantastic perspective by Elif Sozmen on the exciting paper by Carlos Ardavin lab @CNB_CSIC @AdrianVegaPerez

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Katerina Akassoglou

@AkassoglouLab

6 years

Thrilled and deeply honored to receive the 2018 #Barancik Prize for Innovation in #MS Research! I am especially grateful to all lab members, mentors and collaborators, and the @mssociety for all the support. @GladstoneInst @UCSF

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Katerina Akassoglou

@AkassoglouLab

3 years

It was a great honor to give the Rita Levi-Montalcini Neurobiology Keynote Lecture @ISNI_neuro . Thank you so much @MoniqueMarylin for your kind words 🙏 #ISNI2021

Monique Almeida

@MoniqueMarylin

3 years

Outstanding lecture by another exceptional woman scientist who I aspire to become alike. @AkassoglouLab #ISNI2021 @ISNI_neuro

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Katerina Akassoglou

@AkassoglouLab

3 years

Our paper "BMP receptor blockade overcomes extrinsic inhibition of #remyelination and restores neurovascular homeostasis" is now published online @Brain1878 ! #BloodBrainBarrier #neurorepair #MultipleSclerosis (1/n)

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Katerina Akassoglou

@AkassoglouLab

4 years

Live TV interview @ERT3Social on #neuroimmunology @GladstoneInst @UCSF & a funding ecosystem for basic & translational research. Excellent broadcast by Greek national TV promoting #ScienceOutreach in primetime programming @ertofficial_ . Eυχαριστώ!

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Katerina Akassoglou

@AkassoglouLab

4 years

Exciting paper by Christine Stadelmann's lab @jclinicalinvest on immune mechanisms of blood-brain barrier disruption and repair in #neuromyelitis optica independent of astrocytes with striking findings of #fibrinogen deposition in human #NMO brains.

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Katerina Akassoglou

@AkassoglouLab

2 months

@ProfPCDoherty Thank you very much Dr. Doherty @ProfPCDoherty for your kind words on our study.

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Katerina Akassoglou

@AkassoglouLab

3 months

Excited to share a new study in @PNASNews led by Mark Petersen Director of the UCSF Neurointensive Care Nursery that identifies #fibrinogen as a new culprit for #neuroinflammation and impaired #neurogenesis & cerebellar growth in #preterm brain injury.

Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after...

Cerebellar injury in preterm infants with central nervous system (CNS) hemorrhage results in lasting neurological deficits and an increased risk of...

www.pnas.org

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Katerina Akassoglou

@AkassoglouLab

4 years

Extensive #fibrinogen deposition in brains from patients with COVID-19 (median age 50) associated with hyperintensities, macrophage, #microglia , and #astrocyte markers without detection of viral RNA @NEJM

NINDS

@NIH_NINDS

4 years

NIH study uncovers blood vessel damage and inflammation in COVID-19 patients’ brains but no infection

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Katerina Akassoglou

@AkassoglouLab

6 years

Back from a fantastic @ACTRIMS meeting! I accepted the #Barancik Prize on behalf of all the amazing lab members @Gladstone @UCSF @UCSDMedSchool & collaborators. Grateful to @mssociety @BarancikCMBF & Brian Grossman artist & #MS patient who created this magnificent sculpture.

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Katerina Akassoglou

@AkassoglouLab

4 years

"Unlocking the Drivers of Neuroinflammation in Neurodegenerative Disease" August 27, 2020. Looking forward to present our recent data! @GENbio @10xGenomics

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Katerina Akassoglou

@AkassoglouLab

5 years

We are growing our team thanks to our new NIH funding! Positions open for postdocs & research scientists a) protein biochemistry / proteomics, b) neurodegeneration / neuroimmunology @GladstoneInst @UCSF Please RT! Contact info:

Gladstone Institutes

@GladstoneInst

5 years

$4.5 Million to Study How Neurovascular Dysfunction Contributes to Neurodegeneration in #Alzheimer ’s Disease @AkassoglouLab

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Katerina Akassoglou

@AkassoglouLab

2 years

Exciting paper reporting the Fibrin-MRI probe by @PeterCaravan Marcus Makowski. Wonderful replication of our findings on fibrin in EAE w/ clinical implications for Fibrin-MRI as a non-invasive imaging biomarker for neuroinflammation & BBB disruption.

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Katerina Akassoglou

@AkassoglouLab

5 years

Wonderful celebration of the Barancik Prize & my lab @GladstoneInst @UCSF with a surprise guest Cyndi Zagieboylo, President & CEO @mssociety ! The @Akasogloulab is fortunate to be a part of this amazing community and grateful for all the support! @BarancikCMBF @IntNatlWiMS

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Katerina Akassoglou

@AkassoglouLab

4 years

Our #fibrin immunotherapy paper was selected for the @NatImmunol 20th Anniversary Issue! Truly humbled for our work to be included among landmark studies in immunology. Congrats to Jae Kyu Ryu @ZamvilScott @MichelleArkin & amazing team of 35 co-authors!

Nature Immunology - 20 years of Nature Immunology

Twenty antibodies to reflect 20 years of Nature Immunology. To celebrate our anniversary, we have commissioned a series of Comments from some of our authors...

www.nature.com

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Katerina Akassoglou

@AkassoglouLab

6 years

Preview "Inflaming the Brain" by Sidney Strickland and team @RockefellerUniv on our paper on the role of #fibrinogen in #microglia -mediated spine elimination and cognitive decline published today @NeuroCellPress . @GladstoneInst

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Katerina Akassoglou

@AkassoglouLab

2 years

I am so honored to be named @ASPET Fellow in recognition of our research in pharmacology along with amazing colleagues. Grateful to my lab & collaborators @GladstoneInst @UCSF and @UCSDPharm , where I first started my lab!

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Katerina Akassoglou

@AkassoglouLab

26 days

A new @UCSF Life Sciences Building planned to open in 2029 on the San Francisco waterfront will house a life sciences business incubator to extend UCSF’s programs in #innovation & #entrepreneurship and foster growth in CA life sciences & #biotechnology industries.

UC San Francisco

@UCSF

28 days

The UC Regents approved UCSF's Clinical & Life Sciences Building at Dogpatch Power Station! #UCSFProud to bring bench-to-bedside care to SF's waterfront, with a life sciences incubator, primary & specialty care, and a cancer center with proton therapy.

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Katerina Akassoglou

@AkassoglouLab

5 years

Truly grateful to @LiddelowSA for an insightful N&V article on our paper "Don’t you know that you’re #ToxSeq ?" @NatImmunol ! Thank you for the thoughtful commentary & sharing your great ideas for exciting avenues for future research! #neuroimmunology

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Katerina Akassoglou

@AkassoglouLab

2 years

Great session @AmEpilepsySoc #AES2022 on “Microglia in Seizures, Epilepsy & Comorbidity: Advances Illuminating Pathogenic Mechanisms” Exciting talks by @eyolab Amy Brewster Nigel Jones & stimulating questions from the audience. Grateful for the opportunity to share our work!

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Katerina Akassoglou

@AkassoglouLab

3 years

Congrats to Reshmi Tognatta @RTognatta scientist @AkassoglouLab @GladstoneInst @UCSF for being awarded today a @alzassociation Alzheimer’s Association Research Fellowship (AARF) for her exciting new study on #fibrinogen in myelin dysfunction in AD. So proud of her accomplishment!

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Katerina Akassoglou

@AkassoglouLab

3 years

What a great day in Napa wine tasting with the lab! So fortunate to be working with these amazing scientists! We have missed lab gatherings so much and look forward to more get togethers! @andrewmendiola @yan_zhaoqi @RTognatta

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Katerina Akassoglou

@AkassoglouLab

4 years

Honored to contribute an Essay how the discovery was made & thank mentors, trainees, collaborators over 26y journey @uoaofficial @univienna @RockefellerUniv @nyuniversity @UCSDMedSchool @UCSF @GladstoneInst #ImmigrantScience #neuroimmunology #fibrinogen

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Katerina Akassoglou

@AkassoglouLab

2 years

Great fun with the lab getting together with our wonderful families! Their love and support makes everything possible! @AkassoglouLab @GladstoneInst

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Katerina Akassoglou

@AkassoglouLab

3 months

Excited to speak tomorrow at @alzassociation #AAIC24 #AAIC2024 Symposium “Systemic Factors & #Neuroinflammation in #Alzheimers disease” Join us if you are in Philadelphia! 🩸🧠🧬💉

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Katerina Akassoglou

@AkassoglouLab

3 years

Our research on #fibrinogen in Alzheimer's disease and the clinical development of our fibrin-targeting antibody featured by @AARP | AARP's $60 Million Investment in Dementia Research Continues to Pay Off @Rachel_Nania

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Katerina Akassoglou

@AkassoglouLab

3 years

Congratulations to Reshmi Tognatta @RTognatta for receiving today the @GladstoneInst Distinguished Achievement Award in Neuroscience for her postdoc research in our lab on #neurovascular regulation of #remyelination ! So well deserved!

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Katerina Akassoglou

@AkassoglouLab

3 years

Thrilled for @andrewmendiola postdoc @AkassoglouLab for a perfect score on his K99! Grateful to @GladstoneInst @UCSF @NINDSfunding for supporting postdocs from diverse backgrounds to launch independent careers in biomedical research. Looking forward to the great science ahead!

Andrew Mendiola

@andrewmendiola

3 years

Happy to share my @NINDSFunding K99 MOSAIC received a perfect impact score! Grateful to study section for recognizing our work & my potential to enhance diversity in workforce. Thankful to Dr Akassoglou for her mentorship @AkassoglouLab & supportive faculty @GladstoneInst @UCSF !

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Katerina Akassoglou

@AkassoglouLab

4 years

Thank you ImmunoFrontiers for featuring our recent @NatImmunol paper on oxidative stress in neuroinflammation

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Katerina Akassoglou

@AkassoglouLab

2 years

Just arrived at #KSNeuroImmune22 . Looking forward to a great meeting! Thank you @KeystoneSymp @TheColonnaLab Michael Heneka Shilpa Sambashivan for organizing the joint Symposium! 🙏

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Katerina Akassoglou

@AkassoglouLab

3 years

Therini Bio announced today $17M financing by SV Health, Merck & Sanofi Ventures to continue clinical development of fibrin antibody therapeutics based on technology from our lab @GladstoneInst @UCSF @UCSDMedSchool #UniversitySpinout launched by @QB3

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Katerina Akassoglou

@AkassoglouLab

4 months

Excited to share our research tomorrow at the @IVBM2024 Session “Vascular Pathophysiology Unique to the CNS” chaired by @kristyredhorse & sponsored by @vascularbiology & the Korean Society for Vascular Biology and Medicine #KVBM . Join us if you are in Amsterdam! #IVBM2024

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