Magnesium Enables Immune Cells to Tackle Infections and Cancer
A new study has identified extracellular magnesium as a critical immune modulator of CD8+ T cells. Learn more:
👀A sneak peek into the most anticipated
#biotech
event of the year! Don't miss your chance to hear Nobel laureate, Jennifer Doudna
@doudna_lab
discuss the evolution of
#CRISPR
over the years
FREE REGISTRATION:
Mechanisms Underlying SARS-CoV-2 Neuroinvasion Discovered.
Researchers at
@YaleMed
have discovered that SARS-CoV-2 can directly infect the central nervous system. Read more:
#SARSCoV2
#COVID19
#neuroscience
Scientists in Japan say they have designed the first bottom-up peptides that can form artificial nanopores to identify and enable single molecule-sorting of genetic material in a lipid membrane. Read more:
#drugdiscovery
#nanotechnology
“This is the first study in the world to prove that the
#CRISPR
genome editing system can be used to treat
#cancer
effectively in a living animal...” Read more about
@peer_lab
's findings:
Experimental Drug Boosts Brain Cell Cleaning to Reverse Alzheimer's Disease Symptoms
Oral drug therapy resulted in reduced levels of tau protein and protein clumps in two mouse models of Alzheimer’s disease. Read more:
#neuroscience
#alzheimers
Microwave Processing Isolates That Suppress Lung Cancer Metastasis
Scientists have developed a new microwave processing technology to isolate red ginseng compounds that effectively inhibit the metastasis of lung cancer. Read more:
A new study found that the
#SARSCoV2
spike protein can cross the blood–brain barrier (BBB) in mice, strongly suggesting that it can enter the brain. Learn more:
#COVID19
Researchers from Columbia Engineering have developed a system that temporarily disguises therapeutic bacteria from immune systems and allows them to deliver drugs to tumors and kill cancer cells in mice. Learn more:
Researchers Flip the Switch on Immune Response in IBD
Researchers at KU Leuven and Seoul National University developed a method that instructs immune system cells to help repair damaged tissues in the intestine. Learn more:
.
@umichmedicine
researchers report that 6-gingerol, the main bioactive compound in ginger root, has therapeutic effects against certain autoimmune diseases, including lupus and antiphospholipid syndrome (APS), in mice. Learn more:
RNA Editing Is Having a Moment
Although DNA editing has been celebrated for its potential to create new drugs, a relatively unsung alternative, RNA editing, may end up stealing the show. Read more:
Researchers discover what blocks the communication between the gut and the brain and causes insulin resistance in people with
#diabetes
by targeting the Enteric Nervous System. Learn more:
Tea compounds, ECG and EGCG, found in black and green tea have been found to relax blood vessels by activating ion channel proteins. These findings may lead to the development of new therapeutics for hypertension. Learn more:
Researchers investigating the DNA outside our genes (the “dark genome”) report that they have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder. Learn more:
Researchers discover what blocks the communication between the gut and the brain and causes insulin resistance in people with diabetes by targeting the Enteric Nervous System. Learn more:
Researchers Reveal How Killer T Cells Are Blocked from Fighting Cancer Cells.
A new study by scientists at the
@salkinstitute
demonstrates how “bad fats” hinder killer T cells from fighting cancer cells. Learn how:
Ribosomes Shown Translating mRNA from Maternally Inherited Mitochondrial Genome
Specialized mechanism for translation of the mitochondrial genome into proteins revealed. Learn more:
Researchers Uncover Protein That Helps Tumors Evade Immune System
Researchers identify a protein called secreted gelsolin that aids tumors in evading the immune system. Learn more:
The 1st complete telomere-to-telomere sequence of a human autosome has been completed. The sequence of chromosome 8 not only fills in the gap of more than three million bases missing from the current reference genome, but...Read more:
#genomics
#sequencing
Genetics May Play a Role in Our Immune Response to Cancer Treatment
Researchers find Inherited genetic variation plays a role in who is likely to benefit from checkpoint inhibitors. Read more:
Mark your calendars for Wednesday, March 16. Join us live at 2PM ET for our next episode of GEN Live "What COVID-19 Has Revealed about Science & Society"
@PeterHotez
Talks Anti-Science and How to Prevent the Next Pandemic. Register today:
#COVID19
A team from
@MIT
describes a new CRISPR-Cas9
#genomeediting
tool called PASTE, which delivered genes as long as 36,000 DNA base pairs to several types of human cells (as well as to liver cells in mice). Learn more:
#CRISPR
Scientists at .
@HopkinsMedicine
say they have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body. Learn more:
#drugdelivery
“This is the first study in the world to prove that the
#CRISPR
genome editing system can be used to treat
#cancer
effectively in a living animal...” Read more about
@peer_lab
's findings:
#CRISPR
Engineers a New Path for
#Antibiotic
Production
Scientists have discovered a new way of manipulating enzymes in bacteria, through
#geneediting
, which could create a new generation of antibiotics. Read more:
Neural Stem Cells Decline During Aging.
"Much work remains to be done, but this study marks exciting progress towards our goal of identifying prescription drugs that could rejuvenate our brains as we grow older..." Read more:
#neuroscience
#aging
#Omicron
Infections, Without Vaccinations, Provide Little Immunity
Scientists found that without vaccination, infection with Omicron does not provide robust immunity against other
#COVID19
variants. Learn more:
PASTE, Don’t Cut: Genome Editing Tool Looks Beyond
#CRISPR
and Prime
A recently patented
#genomeediting
tool called PASTE holds genuine promise for expanding the universe of treatable genetic diseases. Learn more:
First Genetically Engineered Pig Kidney Transplanted into Living Patient
The kidney transplant marks historic milestone and opens new frontier in transplantation to address kidney shortage affecting millions globally. Read more:
Nanoimaging Gets Some Help from Graphene
Using a molecule called graphene, a single layer of carbon atoms arranged in a 2D honeycomb lattice, the researchers were able to coat cells and keep them alive and wet for much-improved imaging. Read more:
CRISPR-Based Cancer Cell Lineage Tracing Offers Insights into Drivers of Metastasis
Researchers hope that using CRISPR-based technology might enable them to progress from observing
#cancer
cells, to predicting their behavior. Learn more:
#CRISPR
Epigenetic Memory Survives DNA Replication with Aid of Histone-Recycling Protein
Cell identity is preserved during DNA replication by a histone allocation mechanism that involves a replisome component called Mrc1. Read more:
The 1st complete telomere-to-telomere sequence of a human autosome has been completed. The sequence of chromosome 8 not only fills in the gap of more than three million bases missing from the current reference genome, but...Read more:
#genomics
#sequencing
A new CRISPR-Cas9
#genomeediting
tool called PASTE, which can insert large pieces of DNA into several types of human cells, may be able to replace genes in a safer and more efficient way. Learn more:
#CRISPR
CRISPR-Cas9 Screening Enables Phenotypic Development of Antibody Drugs
Antibody drugs may hit entirely new targets now that CRISPR-Cas9 facilitates phenotypic discovery. Learn more:
#CRISPR
To restore vision in the blind, scientists have developed a wide-field, high-density and high-resolution photovoltaic prosthesis for the retina called POLYRETINA that can impart artificial vision. Learn more:
Scientists at the University of California, Irvine (UCI), and the Italian Institute of Technology have developed a new molecule, ALY101, that shows promising anticancer activity against a wide range of tumor cell types and in mouse models. Read more:
🧬FREE VIRTUAL SUMMIT
Less than a week left before The State of
#Biotech
! Don't miss the opportunity to engage in conversations with world-renowned
#scientists
, entrepreneurs, inventors, and academics.
Save your seat here:
Blood-Brain Barrier Control Mechanism Could Point to CNS Therapeutic Strategies
Results from a new study could inform on how the microenvironment is important for blood-brain barrier maintenance. Learn more:
Experimental Drug Boosts Brain Cell Cleaning to Reverse Alzheimer's Disease Symptoms
Oral drug therapy resulted in reduced levels of tau protein and protein clumps in two mouse models of Alzheimer’s disease. Read more:
#neuroscience
#alzheimers
At
@PennMedicine
CAR T cells have been developed that can kill tumor cells in mouse models of neuroendocrine tumors and gastrointestinal cancers. Even better, the CAR T cells show no toxicity toward healthy epithelial cells. Read more:
Improving Cancer Immunotherapy by Blocking Glucose Supply
Memorial Sloan Kettering researchers report that immunotherapy may be improved by altering immune cells' access to sugar. Learn more:
A new study by shows that up to 20% of
#glioblastomas
are powered by overactive
#mitochondria
and may be treatable with drugs currently in clinical trials. Learn more:
Fanzor: First CRISPR-Like System Found in Eukaryotes
The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems. Learn more:
In a first-in-human clinical trial involving four adult glioblastoma patients, an mRNA cancer vaccine developed at the University of Florida (UF) reprogrammed the immune system to attack the tumors. Learn more:
Scientists at
@scrippsresearch
and
@disney_lab
have developed a tool called Chem-CLIP-Fragment Mapping that bypasses "undruggable" proteins, and focuses on RNA to aid in drug discovery of incurable diseases. Read more:
#breastcancer
#RNA
A new study reveals the presence of a fungus commonly found in foods like meat and cheese, preferentially localizes to injured and inflamed regions in the gut in patients with Crohn’s disease, preventing wound healing. Learn more:
A
@Stanford
study shows reprogramming myeloid immune cells can restore youthful bioenergetic metabolism and suppress inflammation in the brain. Learn more:
#aging
Targeted Protein Degradation: A Promising Option for Cancer Drug Developers
Instead of inhibiting disease-causing proteins, targeted protein degraders consign them to proteosomal and endolysosomal pathways. Learn more:
First Alzheimer's Disease
#GeneSilencing
Approach Lowers Tau Levels in Humans
Clinical trial results show promise for a new
#genetic
therapy for
#Alzheimersdisease
that lowers levels of the tau protein known to cause the disease. Learn more:
Researchers have solved the mysterious function of how MCM proteins protect the human cells against DNA instability, which can cause diseases including cancer. Learn more: Learn more:
#mRNA
#Cancer
#Vaccine
Elicits T Cell Response and Eliminates Tumors in Mice
An mRNA-based cancer vaccine, delivered directly into the lymphatic system for a more potent response, eliminates tumors and prevents recurrence in mice. Read more:
Researchers have now explained the mechanisms involved in the loss of smell (anosmia) in patients infected with
#SARSCoV2
at different stages of the disease. Learn more about their findings:
#COVID19
.
@Stanford
study shows reprogramming myeloid immune cells can restore youthful bioenergetic metabolism and suppress inflammation in the brain. Learn more:
A new method combining sequencing and micro-imaging, developed by
@MIT
called in situ
#genomesequencing
, sequences DNA directly within intact biological samples and pinpoints where specific DNA sequences are located inside intact cells. Read more:
#GeneEditing
Startups Cut Fine Therapeutic Figures
New companies are exploiting next-generation
#CRISPR
technologies and powerful
#CRISPR
alternatives to realize new therapeutic approaches. Read more:
Nanoparticle Platform Delivers siRNA Across the Blood-Brain Barrier in Traumatic Brain Injury Mouse Model
The delivery system showed 3Xs more accumulation in the brain than conventional methods. Learn more:
#drugdelivery
#neuroscience
Pin-point, a new base-editing system that uses RNA aptamers to localize DNA modifying effector enzymes at genome targets is adept in performing point-mutation edits and can enhance the therapeutic potential of
#genomeediting
, reported In
@CRISPRjournal
.
A team of researchers has succeeded in inhibiting the immune response induced by
#AAV
antibodies present as a result of natural immunity or following gene therapy. This result opens up new therapeutic prospects. Read more:
#genetherapy
Researchers led by Imperial College London have uncovered new insights into how bacteria hook up to exchange DNA that helps them resist antibiotics. Learn more:
Fructose is added to many of our foods and drinks. Unfortunately, excessive fructose in the brain may contribute to Alzheimer’s disease. Read more about .
@CUAnschutz
's findings :
#alzheimers
#diabetes
Researchers from Finland, Sweden, the U.K., and the U.S. say they have captured ribosomes translating messenger RNA (mRNA) expressed from the maternally inherited genome. Learn more:
Mechanisms Underlying SARS-CoV-2 Neuroinvasion Discovered.
A new study from investigators at
@YaleMed
describes the mechanisms that allow the
#coronavirus
to directly infect the central nervous system.. Read more:
#SARSCoV2
#COVID19
#neuroscience
RNA Editing Is Having a Moment
Although DNA editing has been celebrated for its potential to create new drugs, a relatively unsung alternative, RNA editing, may end up stealing the show. Read more:
CRISPR’s Tricks: How Cas Enzymes Capture, Trim, and Integrate Foreign DNA
New work from Jennifer Doudna’s lab could be useful for CRISPR-based technologies that seek to repurpose Cas1–Cas2 for molecular recording and information storage. Learn more:
A novel tool has been developed to visualize the process of palmitoylation—the post-translational modification that allows peripheral membrane proteins (PMPs) to associate with cellular membranes—in living cells. Learn more:
Scientists from the Global Center for Biomedical Science and Engineering have discovered the mechanism by which molecules called Arl8b and BORC cause increased invasiveness and metastasis in radioresistant cancer cells. Learn more:
#cancer
#radiation
“If our results had been known two years ago, I doubt that anyone would have gone ahead with an attempt to use
#CRISPR
to edit a gene in a human embryo in the clinic..." Read more about .
@ColumbiaMed
latest findings:
#geneediting
#genomeediting
A research team led by
#geneediting
pioneer
@davidrliu
has published how it has applied the technology to develop a one-time treatment for
#spinalmuscularatrophy
that showed effectiveness in cell and mouse models. Learn more:
A new study suggests Alzheimer’s patients who carry a genetic variant that reduces YKL-40 levels maintain their cognitive faculties longer than those individuals without the variant. Read more:
#alzheimers
#circadian
Mild cases of
#COVID19
can trigger robust memory T cell responses, even in the absence of detectable virus-specific antibody responses, suggests an international team of researchers. Continue reading:
Brains devastated by Alzheimer’s disease (AD) can be “rejuvenated” by restoring the expression of a microRNA molecule, report scientists based at the
@leuvenbrainins1
and the
@NIN_knaw
. Learn more:
#alzheimers
Dietary Supplement Reverses Effects of Alzheimer's Disease APOE4 Risk Gene on Lipid Metabolism
@MIT
team hopes that findings will lead to clinical studies to see if choline can help protect against AD in people who carry the APOE4 gene. Read more:
Cellular Engineering Boosts CAR-T Therapy against Solid Tumors
A new strategy of using CAR-T cells against solid tumors leaves healthy cells unharmed. Learn more:
FDA Approves Casgevy, the First CRISPR Therapy, for Sickle Cell Disease
In a truly historic decision today, the FDA approved Casgevy, the groundbreaking
#CRISPR
based
#geneediting
therapy for sickle cell disease, sponsored by
@VertexPharma
. Read more:
Researchers have now explained the mechanisms involved in the loss of smell (anosmia) in patients infected with
#SARSCoV2
at different stages of the disease. Learn more about their findings:
#COVID19
SARS-CoV-2 Disrupts the Immune Response in Intestinal Organoids
Single-cell
#transcriptomics
of
#SARSCoV2
-infected intestinal organoids highlight the gut as a proinflammatory reservoir. Learn more:
Gene Therapy Shows Potential for Repairing Damage Caused by Glaucoma and Dementia
Studies in rodents demonstrate feasibility of using
#genetherapy
to help address complex polygenic diseases. Learn more:
New research shows that bacteria in the gut microbiota of hosts who had previous infections have enhanced resistance to infection. Taurine was also found to induce the enhance resistance of the microbiome. Learn more:
To develop more effective cancer immunotherapies, researchers are turning to various technologies that can detail the interactions between immune cells and cancer cells—interactions that may be attended by phenotypic changes. Read more:
FDA Approves Pfizer’s One-Time Gene Therapy BEQVEZ for Hemophilia B
The BEQVEZ gene therapy inserts a working copy of the Factor IX (FIX) gene that codes for a high-activity FIX variant. Learn more:
#ASGCT
News: Nobel Laureate Jennifer Doudna Opens Presidential Symposium
In Jennifer Doudna's Presidential Symposium keynote at
#ASGCT23
, the Innovative Genomics Institute co-founder highlighted her group’s recent work on T-cell therapies. Read more: