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Serving the biotech industry since 1981. EIC @johnsterling4 ; publisher @liebertpub Subscribe to GEN:

New Rochelle, NY
https://t.co/Y4X2XEYwZL
Joined April 2009
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@GENbio
Genetic Engineering & Biotechnology News
@GENbio
3 years
Magnesium Enables Immune Cells to Tackle Infections and Cancer A new study has identified extracellular magnesium as a critical immune modulator of CD8+ T cells. Learn more:
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2 years
👀A sneak peek into the most anticipated #biotech event of the year! Don't miss your chance to hear Nobel laureate, Jennifer Doudna @doudna_lab discuss the evolution of #CRISPR over the years FREE REGISTRATION:
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4 years
CRISPR Technique Effectively Destroys Metastatic Cancer Cells in Living Animal. Read more: #cancer #oncology #CRISPR
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4 years
CRISPR Pioneers Doudna and Charpentier win 2020 Nobel Prize for Chemistry. Read more: #crispr #geneediting #nobelprize
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@GENbio
4 years
Mechanisms Underlying SARS-CoV-2 Neuroinvasion Discovered. Researchers at @YaleMed have discovered that SARS-CoV-2 can directly infect the central nervous system. Read more: #SARSCoV2 #COVID19 #neuroscience
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4 years
Researchers have modified E. coli to produce chondroitin sulfate, which has been used as a dietary supplement for treating osteoarthritis. Learn more:
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@GENbio
3 years
Scientists in Japan say they have designed the first bottom-up peptides that can form artificial nanopores to identify and enable single molecule-sorting of genetic material in a lipid membrane. Read more: #drugdiscovery #nanotechnology
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Genetic Engineering & Biotechnology News
@GENbio
3 years
CAR T Cells Generated In Vivo Reverse Fibrosis, Restore Cardiac Function in Mice with Heart Failure. Learn more:
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4 years
CRISPR Technique Effectively Destroys Metastatic Cancer Cells in Living Animal. Read more: #cancer #oncology #CRISPR
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4 years
“This is the first study in the world to prove that the #CRISPR genome editing system can be used to treat #cancer effectively in a living animal...” Read more about @peer_lab 's findings:
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4 years
Can a bacterial toxin have a healing effect? A team of researchers has found that the toxin α-hemolysin (Hla) from Staphylococcus aureus stimulates tissue regeneration. Learn more: #tissueregeneration #drugdiscovery #staph #inflammation
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Genetic Engineering & Biotechnology News
@GENbio
3 years
Experimental Drug Boosts Brain Cell Cleaning to Reverse Alzheimer's Disease Symptoms Oral drug therapy resulted in reduced levels of tau protein and protein clumps in two mouse models of Alzheimer’s disease. Read more: #neuroscience #alzheimers
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4 years
Scientists offer a new answer to solve a 100-year-old cancer mystery: The Warburg Effect. Read more: #cancer #warburgeffect
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4 years
Microwave Processing Isolates That Suppress Lung Cancer Metastasis Scientists have developed a new microwave processing technology to isolate red ginseng compounds that effectively inhibit the metastasis of lung cancer. Read more:
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Genetic Engineering & Biotechnology News
@GENbio
4 years
A new study found that the #SARSCoV2 spike protein can cross the blood–brain barrier (BBB) in mice, strongly suggesting that it can enter the brain. Learn more: #COVID19
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Genetic Engineering & Biotechnology News
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2 years
Researchers from Columbia Engineering have developed a system that temporarily disguises therapeutic bacteria from immune systems and allows them to deliver drugs to tumors and kill cancer cells in mice. Learn more:
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Genetic Engineering & Biotechnology News
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4 years
Researchers Flip the Switch on Immune Response in IBD Researchers at KU Leuven and Seoul National University developed a method that instructs immune system cells to help repair damaged tissues in the intestine. Learn more:
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4 years
. @umichmedicine researchers report that 6-gingerol, the main bioactive compound in ginger root, has therapeutic effects against certain autoimmune diseases, including lupus and antiphospholipid syndrome (APS), in mice. Learn more:
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Genetic Engineering & Biotechnology News
@GENbio
8 months
RNA Editing Is Having a Moment Although DNA editing has been celebrated for its potential to create new drugs, a relatively unsung alternative, RNA editing, may end up stealing the show. Read more:
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RNA Editing Is Having a Moment

Although DNA editing has been celebrated for its potential to create new drugs, a relatively unsung alternative, RNA editing, may end up stealing the show.

www.genengnews.com
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Genetic Engineering & Biotechnology News
@GENbio
4 years
Researchers discover what blocks the communication between the gut and the brain and causes insulin resistance in people with #diabetes by targeting the Enteric Nervous System. Learn more:
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Genetic Engineering & Biotechnology News
@GENbio
4 years
Tea compounds, ECG and EGCG, found in black and green tea have been found to relax blood vessels by activating ion channel proteins. These findings may lead to the development of new therapeutics for hypertension. Learn more:
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3 years
Researchers investigating the DNA outside our genes (the “dark genome”) report that they have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder. Learn more:
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4 years
Researchers discover what blocks the communication between the gut and the brain and causes insulin resistance in people with diabetes by targeting the Enteric Nervous System. Learn more:
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Genetic Engineering & Biotechnology News
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3 years
Researchers Reveal How Killer T Cells Are Blocked from Fighting Cancer Cells. A new study by scientists at the @salkinstitute demonstrates how “bad fats” hinder killer T cells from fighting cancer cells. Learn how:
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Genetic Engineering & Biotechnology News
@GENbio
3 years
Epigenetic DNA Methylation Imaged Directly in the Brain Using New eMRI Technique. Learn more:
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4 years
Ribosomes Shown Translating mRNA from Maternally Inherited Mitochondrial Genome Specialized mechanism for translation of the mitochondrial genome into proteins revealed. Learn more:
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3 years
Researchers Uncover Protein That Helps Tumors Evade Immune System Researchers identify a protein called secreted gelsolin that aids tumors in evading the immune system. Learn more:
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3 years
The 1st complete telomere-to-telomere sequence of a human autosome has been completed. The sequence of chromosome 8 not only fills in the gap of more than three million bases missing from the current reference genome, but...Read more: #genomics #sequencing
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4 years
Genetics May Play a Role in Our Immune Response to Cancer Treatment Researchers find Inherited genetic variation plays a role in who is likely to benefit from checkpoint inhibitors. Read more:
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3 years
Mark your calendars for Wednesday, March 16. Join us live at 2PM ET for our next episode of GEN Live "What COVID-19 Has Revealed about Science & Society" @PeterHotez Talks Anti-Science and How to Prevent the Next Pandemic. Register today: #COVID19
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2 years
A team from @MIT describes a new CRISPR-Cas9 #genomeediting tool called PASTE, which delivered genes as long as 36,000 DNA base pairs to several types of human cells (as well as to liver cells in mice). Learn more: #CRISPR
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Genetic Engineering & Biotechnology News
@GENbio
4 years
Scientists at . @HopkinsMedicine say they have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body. Learn more: #drugdelivery
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4 years
“This is the first study in the world to prove that the #CRISPR genome editing system can be used to treat #cancer effectively in a living animal...” Read more about @peer_lab 's findings:
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Genetic Engineering & Biotechnology News
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3 years
#CRISPR Engineers a New Path for #Antibiotic Production Scientists have discovered a new way of manipulating enzymes in bacteria, through #geneediting , which could create a new generation of antibiotics. Read more:
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3 years
Neural Stem Cells Decline During Aging. "Much work remains to be done, but this study marks exciting progress towards our goal of identifying prescription drugs that could rejuvenate our brains as we grow older..." Read more: #neuroscience #aging
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2 years
#Omicron Infections, Without Vaccinations, Provide Little Immunity Scientists found that without vaccination, infection with Omicron does not provide robust immunity against other #COVID19 variants. Learn more:
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1 year
PASTE, Don’t Cut: Genome Editing Tool Looks Beyond #CRISPR and Prime A recently patented #genomeediting tool called PASTE holds genuine promise for expanding the universe of treatable genetic diseases. Learn more:
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4 years
Cannabidiol’s Antibiotic Potential Extends to Gram-Negative Bacteria. Read more: #cannabis #antibiotics #bacteria
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6 months
First Genetically Engineered Pig Kidney Transplanted into Living Patient The kidney transplant marks historic milestone and opens new frontier in transplantation to address kidney shortage affecting millions globally. Read more:
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First Genetically Engineered Pig Kidney Transplanted into Living Patient

Kidney transplant marks historic milestone and opens new frontier in transplantation to address kidney shortage affecting millions globally.

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Genetic Engineering & Biotechnology News
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4 years
Nanoimaging Gets Some Help from Graphene Using a molecule called graphene, a single layer of carbon atoms arranged in a 2D honeycomb lattice, the researchers were able to coat cells and keep them alive and wet for much-improved imaging. Read more:
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4 years
CRISPR-Based Cancer Cell Lineage Tracing Offers Insights into Drivers of Metastasis Researchers hope that using CRISPR-based technology might enable them to progress from observing #cancer cells, to predicting their behavior. Learn more: #CRISPR
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21 days
Epigenetic Memory Survives DNA Replication with Aid of Histone-Recycling Protein Cell identity is preserved during DNA replication by a histone allocation mechanism that involves a replisome component called Mrc1. Read more:
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Epigenetic Memory Survives DNA Replication with Aid of Histone-Recycling Protein

Cell identity is preserved during DNA replication by a histone allocation mechanism that involves a replisome component called Mrc1

www.genengnews.com
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Genetic Engineering & Biotechnology News
@GENbio
3 years
The 1st complete telomere-to-telomere sequence of a human autosome has been completed. The sequence of chromosome 8 not only fills in the gap of more than three million bases missing from the current reference genome, but...Read more: #genomics #sequencing
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Genetic Engineering & Biotechnology News
@GENbio
3 years
A new tool for mitochondrial DNA mutagenesis has emerged—the double-stranded DNA deaminase (DddA)-derived cytosine base editor (DdCBE). Learn more:
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Genetic Engineering & Biotechnology News
@GENbio
2 years
A new CRISPR-Cas9 #genomeediting tool called PASTE, which can insert large pieces of DNA into several types of human cells, may be able to replace genes in a safer and more efficient way. Learn more: #CRISPR
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Genetic Engineering & Biotechnology News
@GENbio
4 years
CRISPR-Cas9 Screening Enables Phenotypic Development of Antibody Drugs Antibody drugs may hit entirely new targets now that CRISPR-Cas9 facilitates phenotypic discovery. Learn more: #CRISPR
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4 years
To restore vision in the blind, scientists have developed a wide-field, high-density and high-resolution photovoltaic prosthesis for the retina called POLYRETINA that can impart artificial vision. Learn more:
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2 years
Scientists at the University of California, Irvine (UCI), and the Italian Institute of Technology have developed a new molecule, ALY101, that shows promising anticancer activity against a wide range of tumor cell types and in mouse models. Read more:
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2 years
🧬FREE VIRTUAL SUMMIT Less than a week left before The State of #Biotech ! Don't miss the opportunity to engage in conversations with world-renowned #scientists , entrepreneurs, inventors, and academics. Save your seat here:
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2 years
Blood-Brain Barrier Control Mechanism Could Point to CNS Therapeutic Strategies Results from a new study could inform on how the microenvironment is important for blood-brain barrier maintenance. Learn more:
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3 years
Experimental Drug Boosts Brain Cell Cleaning to Reverse Alzheimer's Disease Symptoms Oral drug therapy resulted in reduced levels of tau protein and protein clumps in two mouse models of Alzheimer’s disease. Read more: #neuroscience #alzheimers
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Genetic Engineering & Biotechnology News
@GENbio
2 years
At @PennMedicine CAR T cells have been developed that can kill tumor cells in mouse models of neuroendocrine tumors and gastrointestinal cancers. Even better, the CAR T cells show no toxicity toward healthy epithelial cells. Read more:
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4 years
Improving Cancer Immunotherapy by Blocking Glucose Supply Memorial Sloan Kettering researchers report that immunotherapy may be improved by altering immune cells' access to sugar. Learn more:
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4 years
A new study by shows that up to 20% of #glioblastomas are powered by overactive #mitochondria and may be treatable with drugs currently in clinical trials. Learn more:
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1 year
Fanzor: First CRISPR-Like System Found in Eukaryotes The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems. Learn more:
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4 months
In a first-in-human clinical trial involving four adult glioblastoma patients, an mRNA cancer vaccine developed at the University of Florida (UF) reprogrammed the immune system to attack the tumors. Learn more:
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4 years
Scientists at @scrippsresearch and @disney_lab have developed a tool called Chem-CLIP-Fragment Mapping that bypasses "undruggable" proteins, and focuses on RNA to aid in drug discovery of incurable diseases. Read more: #breastcancer #RNA
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3 years
A new study reveals the presence of a fungus commonly found in foods like meat and cheese, preferentially localizes to injured and inflamed regions in the gut in patients with Crohn’s disease, preventing wound healing. Learn more:
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4 years
A @Stanford study shows reprogramming myeloid immune cells can restore youthful bioenergetic metabolism and suppress inflammation in the brain. Learn more: #aging
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1 year
Targeted Protein Degradation: A Promising Option for Cancer Drug Developers Instead of inhibiting disease-causing proteins, targeted protein degraders consign them to proteosomal and endolysosomal pathways. Learn more:
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@GENbio
2 years
Researchers at @UofT and @nyugrossman developed a novel #artificialintelligence technology, called ZFDesign, that can design #zincfinger proteins to target any stretch of DNA in the human genome. Learn more: #genetherapy #genetics #genomeediting
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1 year
First Alzheimer's Disease #GeneSilencing Approach Lowers Tau Levels in Humans Clinical trial results show promise for a new #genetic therapy for #Alzheimersdisease that lowers levels of the tau protein known to cause the disease. Learn more:
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6 years
Researchers develop a genome editing tool for the potential treatment of mitochondrial diseases:
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4 years
Researchers have solved the mysterious function of how MCM proteins protect the human cells against DNA instability, which can cause diseases including cancer. Learn more: Learn more:
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2 years
#mRNA #Cancer #Vaccine Elicits T Cell Response and Eliminates Tumors in Mice An mRNA-based cancer vaccine, delivered directly into the lymphatic system for a more potent response, eliminates tumors and prevents recurrence in mice. Read more:
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3 years
Researchers have now explained the mechanisms involved in the loss of smell (anosmia) in patients infected with #SARSCoV2 at different stages of the disease. Learn more about their findings: #COVID19
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4 years
. @Stanford study shows reprogramming myeloid immune cells can restore youthful bioenergetic metabolism and suppress inflammation in the brain. Learn more:
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4 years
A new method combining sequencing and micro-imaging, developed by @MIT called in situ #genomesequencing , sequences DNA directly within intact biological samples and pinpoints where specific DNA sequences are located inside intact cells. Read more:
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4 years
#GeneEditing Startups Cut Fine Therapeutic Figures New companies are exploiting next-generation #CRISPR technologies and powerful #CRISPR alternatives to realize new therapeutic approaches. Read more:
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4 years
Nanoparticle Platform Delivers siRNA Across the Blood-Brain Barrier in Traumatic Brain Injury Mouse Model The delivery system showed 3Xs more accumulation in the brain than conventional methods. Learn more: #drugdelivery #neuroscience
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4 years
Pin-point, a new base-editing system that uses RNA aptamers to localize DNA modifying effector enzymes at genome targets is adept in performing point-mutation edits and can enhance the therapeutic potential of #genomeediting , reported In @CRISPRjournal .
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4 years
A team of researchers has succeeded in inhibiting the immune response induced by #AAV antibodies present as a result of natural immunity or following gene therapy. This result opens up new therapeutic prospects. Read more: #genetherapy
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2 years
Researchers led by Imperial College London have uncovered new insights into how bacteria hook up to exchange DNA that helps them resist antibiotics. Learn more:
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4 years
Fructose is added to many of our foods and drinks. Unfortunately, excessive fructose in the brain may contribute to Alzheimer’s disease. Read more about . @CUAnschutz 's findings : #alzheimers #diabetes
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4 years
Researchers from Finland, Sweden, the U.K., and the U.S. say they have captured ribosomes translating messenger RNA (mRNA) expressed from the maternally inherited genome. Learn more:
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4 years
Mechanisms Underlying SARS-CoV-2 Neuroinvasion Discovered. A new study from investigators at @YaleMed describes the mechanisms that allow the #coronavirus to directly infect the central nervous system.. Read more: #SARSCoV2 #COVID19 #neuroscience
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10 months
RNA Editing Is Having a Moment Although DNA editing has been celebrated for its potential to create new drugs, a relatively unsung alternative, RNA editing, may end up stealing the show. Read more:
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1 year
CRISPR’s Tricks: How Cas Enzymes Capture, Trim, and Integrate Foreign DNA New work from Jennifer Doudna’s lab could be useful for CRISPR-based technologies that seek to repurpose Cas1–Cas2 for molecular recording and information storage. Learn more:
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2 years
A novel tool has been developed to visualize the process of palmitoylation—the post-translational modification that allows peripheral membrane proteins (PMPs) to associate with cellular membranes—in living cells. Learn more:
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4 years
Scientists from the Global Center for Biomedical Science and Engineering have discovered the mechanism by which molecules called Arl8b and BORC cause increased invasiveness and metastasis in radioresistant cancer cells. Learn more: #cancer #radiation
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4 years
“If our results had been known two years ago, I doubt that anyone would have gone ahead with an attempt to use #CRISPR to edit a gene in a human embryo in the clinic..." Read more about . @ColumbiaMed latest findings: #geneediting #genomeediting
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4 years
Scientists Develop ON-OFF Switch for CAR T Cell Immunotherapy. Learn more:
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1 year
A research team led by #geneediting pioneer @davidrliu has published how it has applied the technology to develop a one-time treatment for #spinalmuscularatrophy that showed effectiveness in cell and mouse models. Learn more:
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3 years
#SARSCoV2 D614G Mutation Stabilizes Spike Protein, May Explain Faster Spread. Find out how:
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4 years
A new study suggests Alzheimer’s patients who carry a genetic variant that reduces YKL-40 levels maintain their cognitive faculties longer than those individuals without the variant. Read more: #alzheimers #circadian
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4 years
Mild cases of #COVID19 can trigger robust memory T cell responses, even in the absence of detectable virus-specific antibody responses, suggests an international team of researchers. Continue reading:
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3 years
Brains devastated by Alzheimer’s disease (AD) can be “rejuvenated” by restoring the expression of a microRNA molecule, report scientists based at the @leuvenbrainins1 and the @NIN_knaw . Learn more: #alzheimers
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@GENbio
4 years
Dietary Supplement Reverses Effects of Alzheimer's Disease APOE4 Risk Gene on Lipid Metabolism @MIT team hopes that findings will lead to clinical studies to see if choline can help protect against AD in people who carry the APOE4 gene. Read more:
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6 years
Duchenne Muscular Dystrophy Mutation in Dogs Reversed by #CRISPR -Cas9:
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3 years
Cellular Engineering Boosts CAR-T Therapy against Solid Tumors A new strategy of using CAR-T cells against solid tumors leaves healthy cells unharmed. Learn more:
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9 months
FDA Approves Casgevy, the First CRISPR Therapy, for Sickle Cell Disease In a truly historic decision today, the FDA approved Casgevy, the groundbreaking #CRISPR based #geneediting therapy for sickle cell disease, sponsored by @VertexPharma . Read more:
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3 years
Researchers have now explained the mechanisms involved in the loss of smell (anosmia) in patients infected with #SARSCoV2 at different stages of the disease. Learn more about their findings: #COVID19
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6 years
Artificial Sensory Nerves May One Day Provide Prosthetic Limbs with Sense of Touch:
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3 years
SARS-CoV-2 Disrupts the Immune Response in Intestinal Organoids Single-cell #transcriptomics of #SARSCoV2 -infected intestinal organoids highlight the gut as a proinflammatory reservoir. Learn more:
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Genetic Engineering & Biotechnology News
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3 years
Gene Therapy Shows Potential for Repairing Damage Caused by Glaucoma and Dementia Studies in rodents demonstrate feasibility of using #genetherapy to help address complex polygenic diseases. Learn more:
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Genetic Engineering & Biotechnology News
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4 years
New research shows that bacteria in the gut microbiota of hosts who had previous infections have enhanced resistance to infection. Taurine was also found to induce the enhance resistance of the microbiome. Learn more:
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4 years
To develop more effective cancer immunotherapies, researchers are turning to various technologies that can detail the interactions between immune cells and cancer cells—interactions that may be attended by phenotypic changes. Read more:
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4 months
FDA Approves Pfizer’s One-Time Gene Therapy BEQVEZ for Hemophilia B The BEQVEZ gene therapy inserts a working copy of the Factor IX (FIX) gene that codes for a high-activity FIX variant. Learn more:
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1 year
#ASGCT News: Nobel Laureate Jennifer Doudna Opens Presidential Symposium In Jennifer Doudna's Presidential Symposium keynote at #ASGCT23 , the Innovative Genomics Institute co-founder highlighted her group’s recent work on T-cell therapies. Read more:
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. @MIT researchers design an inhalable form of mRNA, an advance that could lead to new treatments for lung disease:
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Inhaled mRNA Therapy Could Be Breath of Fresh Air for Lung Disorders

Patients with lung disease could find relief by breathing in messenger RNA molecules

www.genengnews.com
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