Robert Insall @robinsall Twitter profile | Pikagi

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Robert Insall

@robinsall

3,909

Followers

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Following

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Cell movement, prof of biology, mathematics and cancer. ♥ microscopes, models, machine learning. Cell migration & chemotaxis @UCL @robinsall .bsky.social

Just moved down to Cambridge

https://t.co/EvX8N67JOs

Joined May 2012

Don't wanna be here? Send us removal request.

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@robinsall

Robert Insall

13 days

Now with link: I will have two postdoc positions and a technical post in my new(ish) lab in UCL. One biased to wet experiments with chemoattractant gradients, and one more based on modelling and maths. But both posts encompassing both. Drop me a line!

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UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

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@robinsall

Robert Insall

6 years

@PaulMMCooper Last heatwave, my dad discovered a circular fort with a long straight wall intersecting it, by looking from his roof. Turned out to be markings from an old footie pitch :)

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@robinsall

Robert Insall

2 years

It is my great pleasure to congratulate the magnificent @LMachesky , just elected to be president of the British Society for Cell Biology @BSCB . What a star in the firmament...

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@robinsall

Robert Insall

1 year

@chrisgolds "Listen. Strange women lying in ponds distributing swords is no basis for a system of government. Supreme executive power derives from a mandate from the masses, not from some farcical aquatic ceremony" Monty Python

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@robinsall

Robert Insall

3 years

Read two new papers about "master regulators" today. I reiterate my belief - master regulators almost never exist. They are created by scientists' desire to be important & get their papers published, not something Mother Nature uses much.

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@robinsall

Robert Insall

9 months

Cell seems to have 100% morphed into the "journal of scRNAseq atlases". Apparently no other modes of science are accepted...

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@robinsall

Robert Insall

9 months

Grand change! As from today I have completed my move south. I have joined the faculty at UCL. My lab will move to the excellent Department of Cell & Developmental Biology ( @uclcdb ) over the next few months. Very much looking forward to the challenge & new collaborations...

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@robinsall

Robert Insall

2 years

Counting "years since your PhD" is not only discriminatory, but awful for the quality of science. It massively favours researchers who do exactly what their boss did, over ones who actually take the trouble to develop their own systems and their own ideas.

@AlejoFraticelli

Alejo Rodriguez-Fraticelli, PhD

@AlejoFraticelli

2 years

@Jeff_Mold My two cents here. The true problem is this nonsense of evaluating early career grants/awards based on “how many years after you’ve spent after your PhD”. That is crazy, agist, sexist, racist, just the most discriminatory practice that we have in academic science.

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@robinsall

Robert Insall

4 years

So I have a nice Christmas present. My @Wellcometrust Investigator grant, to study self-generated gradients in lymph nodes, was funded & will start next spring. Most grateful, also to the large assembly of co-workers and collaborators who've made an aggressive project feasible.

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@robinsall

Robert Insall

2 years

Many congratulations to the estimable @LMachesky , elected to the Dunn Chair of Biochemistry in Cambridge - the most senior biochemistry position in Cambridge, and in fact almost anywhere... Well done!

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@robinsall

Robert Insall

7 years

@dlittleton1 @RepCohen

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@robinsall

Robert Insall

7 months

@DimitrisPapail Elon Musk's will own the libs by answering "12"

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@robinsall

Robert Insall

6 years

@Himynameisnoor Followed. Immediately and unquestioningly. (for the quality of the narrative more than the bizarre tale)

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@robinsall

Robert Insall

1 year

You cannot be serious? UK is going to be a "science superpower" but foreign scientists will be charged so much they leave and/or won't come? That is just moronic. Little England, the very small superpower.

@SkyNews

Sky News

1 year

How are the govt going to fund paying public sector workers more? 'The fee for migrants applying for visas and accessing the NHS will go up - that will raise over £1bn,' Rishi Sunak explains. 📺 Sky 501, Virgin 602

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@robinsall

Robert Insall

4 years

Fantastic. A leader who can do logic and maths. Much admiration, and a desire to find one for where I live.

@Nopanaden

Alberto García-Salido

4 years

Un ejemplo.

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@robinsall

Robert Insall

4 years

If you have to wear a mask to shop - wear a good one!

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@robinsall

Robert Insall

1 year

A short thread about Adam Dowdell's excellent chemotaxis paper, just out in @CurrentBiology . It shows how combinations of ligands for the same receptors cause fascinating & counterintuitive outcomes (1/n)

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Competition between chemoattractants causes unexpected complexity and can explain negative chemot...

Competition between different ligands for the same receptor type can explain how cells can drive negative chemotaxis in which cells migrate away from a chemical repellent. Dowdell et al. show that...

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@robinsall

Robert Insall

3 years

Cool, multidisciplinary jobs in computational and cell biology! Please join my group, & discover why cells go where they go. T cells, dendritic cells, Dictyostelium, neutrophils... Target = one mathematical modeller and one immune cell biologist, but we'd train anyone excellent

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@robinsall

Robert Insall

2 years

New chemotaxis preprint! Repulsion of cells by a chemical - 'chemorepulsion' - caused by competition with other attractants, not by direct repulsion. The most remarkable result is at the end (movie 5). 1/n

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Competition between chemoattractants causes unexpected complexity and can explain negative chemot...

Negative chemotaxis, where eukaryotic cells migrate away from repellents, is important throughout biology, for example in nervous system patterning and resolution of inflammation. However, the...

www.biorxiv.org

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@robinsall

Robert Insall

3 years

What is this thing with Cell about publishing massive datasets gathered at vast cost that confirm what we already know?

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@robinsall

Robert Insall

4 years

@mr_ian PhD student set her lunch on fire by microwaving it excessively. Thinking quicky, she threw it into the trash. Which was filled with scrumpled paper towels and plastic sheets, so obviously wooshed into flame. Much hilarity ensued. And some amount of inflammation.

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@robinsall

Robert Insall

3 years

I will have one or two positions later this year, for cell biologists to study migration of immune cells in lymph nodes. If you're interested could you get in touch please? Email, Twitter, semaphore, whatever...

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@robinsall

Robert Insall

5 years

@FOMconferences @SuperResoluSian @gailmcconnell @SusanSuperRes Folks, until you accidentally make an all-female program, this just won't wash....

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@robinsall

Robert Insall

3 years

@britt4jade @marklewismd (presuming this is a real question; hope so) Every protein, in every cell in your body, is made using mRNA as a template ("instructions" if you will). The devil in so-called "mRNA technology" is making cells use mRNA you feed them; cells are smart and recognise it as foreign.

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@robinsall

Robert Insall

5 years

@carolecadwalla _Farage_ is accusing someone of sneering, in a horrible sneering Tweet? Lucky he doesn't do irony...

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@robinsall

Robert Insall

4 years

Oooh! The message is spreading!

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Cancer cells can navigate maze

Cancer cells have demonstrated an uncanny ability to “sniff” their way around a maze in an experiment that recreated the labyrinth at Hampton Court Palace.Scientists at the Cancer Research UK Beatson...

www.thetimes.com

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@robinsall

Robert Insall

3 years

I am reviewing a huge stack of grants and getting really, REALLY narked off by candidates making grandiose statements that they are proposing vast intellectual strides, when the actual material shows they obviously aren't.

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@robinsall

Robert Insall

1 year

Huge congratulations to the excellent @LMachesky , new president of the @Official_BSCB

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@robinsall

Robert Insall

3 years

New boss. Yay! Sounds a truly cool scientist.

@UofGCancerSci

UofG Cancer Sciences

3 years

Congratulations to Professor Laura Machesky @LMachesky who has been appointed as Director of the @UofGlasgow Institute of Cancer Sciences from 1st May 2021 for a period of five years 👏fantastic news Laura

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@robinsall

Robert Insall

4 years

Unexpected medical consequence of Covid: I refuse to trim my beard while locked down. So yesterday, to lighten up life a bit, my daughter dyed it bright green. Glanced in the mirror just after waking up and nearly had a heart attack...

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@robinsall

Robert Insall

5 years

@Keith53yrsAV @Jacob_Rees_Mogg ...to the 1800s...

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@robinsall

Robert Insall

9 months

Huge congratulations to Penn for their unstinting support for a faculty member who needed a bit of help to complete her world-leading research.

@Penn

Penn

9 months

Katalin Karikó and Drew Weissman, Penn’s historic mRNA vaccine research team, win 2023 @NobelPrize in Medicine #nobelprize

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@robinsall

Robert Insall

2 years

"Leading Scientists"! It's in the papers, it must be true.

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@robinsall

Robert Insall

3 years

Because what cell biology really needed was another arbitrary descriptive name for actin cell protrusions (particularly since the term "filopodia" is so precisely and tightly defined...)

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Endothelial cell invasion is controlled by dactylopodia | PNAS

Sprouting angiogenesis is fundamental for development and contributes to cancer, diabetic retinopathy, and cardiovascular diseases. Sprouting angio...

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@robinsall

Robert Insall

3 years

@baym If you're going to get diagnosed with cancer in 10 years, you probably have it now. If you're male and over 60, you probably have prostate cancer.

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@robinsall

Robert Insall

4 years

Second prize: Sophie Claydon's picture of melanoma cells fighting. En garde!

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@robinsall

Robert Insall

7 months

Wish scientists could stop finding new ways to judge other scientists. If it's not "X doesn't publish in Cell" then it's "X does publish in MDPI" or this "X doesn't preprint". Enough, already. Read the science and begin from there. Lay off the proxies.

@drdevangm

Devang Mehta 🌱👨🏽‍🔬🧬

7 months

💯 this may sound uncharitable but honestly, I too look at papers that never appeared on bioRxiv with greater scrutiny, wondering what the authors were trying to hide… “Scientists, have we lost the plot?” by KamounLab

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@robinsall

Robert Insall

6 years

I❤️ @J_Cell_Sci Journal of Cell Science now offers expedited ‘fast-track’ decisions (within a week) for previously reviewed manuscripts that are submitted with reports.

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@robinsall

Robert Insall

2 years

So - we wrote a review! Here's a free link. #chemotaxis #selfgeneratedgradients #cellmotility #computationalmodelling #devbio #immunology

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Robert Insall

1 year

OMG. The sort of advance we thought was just absolutely impossible. Happening, now. Incredible, and life-renewing.

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Walking naturally after spinal cord injury using a brain–spine interface

Nature - A reliable digital bridge restored communication between the brain and spinal cord and enabled natural walking in a participant with spinal cord injury.

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@robinsall

Robert Insall

3 years

@baym (incidentally, the solution to both points is "go out, live your life, have fun and do stuff" - no point hiding from cancer)

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@robinsall

Robert Insall

1 year

@WeirdMedieval seems a nice chap

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@robinsall

Robert Insall

5 years

Postdoctoral position available. Fancy new FLIM microscopes, organoids, G-protein signalling visualisation in time and space, self-generated gradients and lots of modellers as colleagues - what's not to like? Apply online; ask me for details in person.

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@robinsall

Robert Insall

4 years

I have a Y chromosome joke. It's really short & doesn't contain much sense.

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@robinsall

Robert Insall

4 years

Another of my dad's VE day photographs. Exquisite work

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@robinsall

Robert Insall

1 year

I will have a postdoc position available in May! Scar/WAVE complex, actin, microscopy, chemotaxis. Drop me a line if interested. Will post and ad when we make one...

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@robinsall

Robert Insall

3 years

I 💕 Dictyostelium when it does math

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@robinsall

Robert Insall

7 years

@OfficialMrGray @mikebtweet @RachJBurns @trevor_parsnip @speccyfoureyes1 @Le_Jackal Some masses are not good enough for humour

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@robinsall

Robert Insall

5 years

Another absolute triumph for #frugalscience Tweeps - we can do this - we can make science not the rip-off monoopoly of huge labs with huge grants and kits...

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Bio-On-Magnetic-Beads (BOMB): Open platform for high-throughput nucleic acid extraction and...

This Community Page article presents open-source nucleic acid purification and handling protocols based on functionalised magnetic beads, with the aim of transforming life science research practice...

journals.plos.org

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@robinsall

Robert Insall

10 months

This really is delightful work. It has the rare property that it changes everything - dendritic cells (and thus the whole immune system) work in a different way than we previously thought. Knowing this means we can understand other things better.

@SciImmunology

Science Immunology

10 months

Dendritic cells can “self-shape” the chemotactic gradients that help them transport antigens to lymph nodes, finds a new live imaging study from @Sixt_Lab @EdouardHannezo . 📄: Focus by @hannahdonnelly_ @EMandrou @robinsall :

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@robinsall

Robert Insall

5 years

@FritzLaylin @CyrilPedia @JCBeditor This is not really ready to show (no calibration, not optimal speed) but it rather makes the point. Mammalian cell motility peeps please realise - this is not timelapsed. This is what you see down the eyepieces.

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@robinsall

Robert Insall

4 years

@Truthisunpopul1 @carlbergstrom Because, unlike right-wing Twitterers, he has both knowledge and experience to back up his opinion; because fewer people die when public health is staffed by people who understand, y'know, public health; and because "truth" is better supported by scholarship than shouty opinion.

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@robinsall

Robert Insall

4 years

I would dye for my family...

@jessicainsall

Jess Insall

4 years

Families that hair dye together stay together 💚💕

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@robinsall

Robert Insall

4 years

@baym This Tweets is poorly constructed. There is a lack of mechanism throughout, the aims are over-ambitious, and it is merely incremental over similar tweets. Plus, the field does not regard tweets of this sort as sound or impactful.

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@robinsall

Robert Insall

7 months

Very sorry to be reminded that, in the UK government's definition of science, a postdoctoral scientist is not considered "skilled". Top grades, plus a minimum 3-4 years BA plus 3-5 years PhD, plus extremely high-level expertise are all essential. But not, it seems, skilled...

@10DowningStreet

UK Prime Minister

@10DowningStreet

7 months

We’re increasing the minimum earnings threshold for skilled workers by 48% to £38,700, encouraging businesses to look to British talent first and invest in their workforce.

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Robert Insall

5 years

@NiemannJanice My other half got asked to apply for a job by the head of the search committee - "exactly who we're after". She replied "You rejected me for it - last week". Turned out they'd asked the departmental secretary to toss all applications without a CNS paper in the last 18 months.

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@robinsall

Robert Insall

3 years

Birthday congratulations to the superlative @CurrentBiology - the most interesting journal out there...

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@robinsall

Robert Insall

4 years

1st prize: "Actin Blossom" by Simona Buracco. Also (ahem) from @robinsall group. Well done Simona! Lovely @BairBeatson

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@robinsall

Robert Insall

3 years

Life is good. I made a tarte Tatin with pears and muscovado sugar. To be eaten with vanilla ice cream. Fattening.

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@robinsall

Robert Insall

6 months

Marvellous paper. How Talin manages to bind both actin and integrins and still be a clutch. This is why I still use Twitter despite everything - H/T @MJ_Humphries & @myosinactncrazy - wouldn't have seen it without you both.

Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin

Nature Communications - Focal adhesion proteins transmit intracellular forces to the extracellular matrix (ECM). Here, the authors show a force transmission by elastic transient clutch of Talin...

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@robinsall

Robert Insall

5 years

@Peston @theresa_may No. A catastrophic Brexit would deal a blow to public confidence in everything, however.

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@robinsall

Robert Insall

1 year

@mrjamesob James, just hush. Let them reinstate Johnson. Then watch the election. Sometimes people just have to learn by doing and by hard knocks.

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@robinsall

Robert Insall

4 years

@yufan2016 @AustinDocherty @ConMend @dannywallace You think Bill Gates controlling you makes you use efficient methods? Sheep.

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@robinsall

Robert Insall

6 years

@DomMitchell @Tony_Robinson @gsoh31 this habit of Corbynites yelling at Labour voters to STOP and go and join the Tories is some pretty weird sh*t. Not, you would think, a clever way to advance a political movement, but happening all over Twitter

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@robinsall

Robert Insall

1 year

Just processing the pics. Seems we didn't get the best angle. Still lovely...

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@robinsall

Robert Insall

1 year

Aurora movie. Look at the stars moving, too!

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@robinsall

Robert Insall

3 years

I genuinely don't understand this phenomenon. First noticed it about a decade ago, but it gathers energy all the time. Why does the field encourage people to say stuff that is somewhere between self-praise and overt lying? Aren't we supposed to be _scientists_, not circus shows?

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@robinsall

Robert Insall

5 years

@StatGirlLAM @fergilmills @IsabellaGhement Well known medico-legal joke. "X agrees to pay Y $1000 per anum" - we all know about paying through the arse, but in this case it's in the contract 🙂

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@robinsall

Robert Insall

2 years

Lovely. But the thing that baffles me? In a world full of exquisite movies like this, the literature is still full of "upstream pathways" and "master regulators". There is no upstream in a positive feedback loop, and nobody is the master...

@BPoD_s

BPoD

2 years

Mapping the circuit of molecular interactions that control the cytoskeleton. Video and research by @AniMichaud1 et al @GoryachevAndrew , George von Dassow, @BementLab @UWMadison @uoregon @EdinburghUni in @JCellBiol . More on with @MRC_LMS and @sophtalkssci

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@robinsall

Robert Insall

6 years

What the heck is wrong with you, @FEBSnews @FEBSJournal ? This is 2018! Are you only able to find a single female scientist in Europe for a "50 Years of FEBS" conference? Hang your organisational head in shame!

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@robinsall

Robert Insall

4 years

Science officer job. Come and join my group! We do all sorts of cool science, from cell migration to deep learning. Position for 15 months in the first instance as I move from the Beatson to @UofGCancerSci next door - but the lab will still need help.

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@robinsall

Robert Insall

4 years

@JohnBoudet @CT_Bergstrom A comment that says much, much more about the commenter.

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@robinsall

Robert Insall

4 years

Is this any good? Asking for a friend... (thanks, Science Twitter)

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@robinsall

Robert Insall

1 month

@RobertJenrick Your government impose much of our business model, including educating UK students at a loss. Something has to make up the difference. The wisest thing to do would be fund UK students' education fully. If you can't manage that, please don't hamstring our ability to compensate.

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@robinsall

Robert Insall

5 years

A very good article; all should read it. However it misses (for me) the elephant in the room - there are too many scientists trained, for not enough good jobs. No use saying "slow down and don't compete!" at a cadre who must compete for one job per ten scientists.

@TrendsCognSci

Trends in Cognitive Sciences

5 years

"Fast Science is bad for scientists and bad for science." --Uta Frith, Fast Lane to Slow Science #slowscience

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Robert Insall

4 years

Learning from the greats! Next time I send a paper to an editor, I'm going to copy the cover letter from Hooke's Micrographia...

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@robinsall

Robert Insall

4 years

The die is cast. I will resign my job and retrain. As - a jet-powered paramedic.

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@robinsall

Robert Insall

14 days

At last - a meme describing what it's like to be an actual crossdisciplinary scientist...

@Rainmaker1973

Massimo

15 days

Four years ago a donkey named Diesel went missing in Wyoming. He's now part of an elk community

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Robert Insall

4 years

Don't these morons know anything? It's **Professor** University of Glasgow.

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@robinsall

Robert Insall

1 year

I wrote a review! Get yourself a PDF of it here:

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@robinsall

Robert Insall

3 years

**sigh** let's hope this new one is much better, shall we? Happy 2021 everyone.

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@robinsall

Robert Insall

2 years

Watch it. Then pick up your jaw and watch it again...

@Lush_Biology

Lush_Biology

2 years

Lateral line primordium migration in a developing zebrafish. Transgenic is cxcr4b:H2B-GFP made by the Knaut lab. @LabPiotrowski #zebrafish

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@robinsall

Robert Insall

6 months

Tech post available in my new group at UCL, with a very broad range of interesting work to do. Microscopes, microfluidics, computer modelling, molecular genetics... Come and join us!

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UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

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@robinsall

Robert Insall

3 years

Science careers. Here are the questions I would like to see addressed, in this week of reports and proposals. 1. How many research labs is the right number? Does adding more make proportionally more, better science? Or does it stress the system more and restrict insight? ../

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@robinsall

Robert Insall

1 year

@mbeisen @PLOSONE Because anyone who has run a lab, with actual postdocs and PhD students who want actual jobs, knows it would hurt them. Unfortunately you either play by the rules everyone else plays by, or leave the game. Even if you think the rules are wrong or foolish.

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@robinsall

Robert Insall

4 years

Marvellous! The UK government is building a new vaccine centre in - Oxford. Because that's one of only two towns where anyone has any brains. Sad there aren't enough houses, schools, or doctors for the scientists, and planning laws won't allow new ones.

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@robinsall

Robert Insall

3 years

My garden looking nice in the snow, though I say so myself.

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Robert Insall

1 year

Unbeliveably tone-deaf strategy CRUK is adopting. New Clinical Trials Units overwhelmingly in the South. And now they're closing Scotland's one unit. Apparently southern English folks' cancer needs much more careful attention...

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'Shock and outrage' as Cancer Research axes funding for Beatson clinical trials unit

A spokesman for NHS GGC said: “The vast majority of cancer trials being run at the Beatson are completely unaffected by this decision.

www.heraldscotland.com

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Robert Insall

5 years

@mbeisen @emayfarris she said wrong answers only

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@robinsall

Robert Insall

6 years

@markbishopuk @ChrisS144 @DivyaDattani @Paul_Kasner @DrPhillipLeeMP That's what it's come to. All you are able to do is string words like "remoaner", "arrogance", "you lot" and "suck it up". There's not even an attempt at substance or reason anymore; that has simply eroded away...

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@robinsall

Robert Insall

7 years

Academic Irony 4: Why share data? Official answer: - comply with policies - legal requirements - increases impact - adds to REF returnability Correct answer: Because we're scholars! Unshared data is worthless. It might as well not be data.

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@robinsall

Robert Insall

3 years

Superb issue! Please read! Superb cover from #CytoMorphoLab !

@CurrentBiology

Current Biology

@CurrentBiology

3 years

Our latest issue is out! And it’s special! Jam-packed with reviews, primers, quickguides on the #cytoskeleton 👇

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Robert Insall

3 years

@Trumpetmike @joswinson Tiktok ads suddenly start flashing MULTIBALL Immense flippers start twanging in front of the goals

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@robinsall

Robert Insall

4 years

Apparently 1960s microscopes and Brexit isolationism are thought to be very attractive to overseas researchers.

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@robinsall

Robert Insall

4 years

Daughter bored of lockdown. Entered competition to build a freestanding tower to raise some school uniform. Potential prize substantially less than the value of my duck tape nicked. Still cool.

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@robinsall

Robert Insall

5 years

But my friends, what did you expect? All probes affect their targets, especially at the microscale. Still, glad it's been measured.

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Lifeact-TagGFP2 alters F-actin organization, cellular morphology and biophysical behaviour

Scientific Reports - Lifeact-TagGFP2 alters F-actin organization, cellular morphology and biophysical behaviour

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@robinsall

Robert Insall

2 years

Trends review is out!

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@robinsall

Robert Insall

3 years

@HenriquesLab If it was easy, someone else would have done it...

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@robinsall

Robert Insall

4 years

@OdedRechavi If enough cash (sorry wifie) - be a home scientist. Develop DIY kit (incubators, foldscopes, etc) and poke at the things I feel like (amoebas from the pond up the hill). Forget the impact agenda and do interesting stuff.

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@robinsall

Robert Insall

1 year

A piece I wrote on Twitter in science communication. Was very scared it would be completely wrong by the time it was published! But things haven't changed that fast, fortunately.

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