Paul Maidowski @_ppmv Twitter profile | Pikagi

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Paul Maidowski

@_ppmv

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2,816

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Solar PV, climate policy, bamboo analysis/consulting. Language, systems. Fletcher/Fulbright. d|e|f|i|中围棋 @ppmv .bsky.social

Berlin

Joined December 2010

Don't wanna be here? Send us removal request.

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@_ppmv

Paul Maidowski

24 days

Is bamboo our best chance to sustain modern civilization and slow climate change? No one systematically studies its global potential in food, paper, energy, & construction yet. To build resilient economic and ecosystems, we need to grow bamboo where it is needed, incl Europe 👇☕️

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@_ppmv

Paul Maidowski

2 months

‘Brain fog’ is better called SARS associated neurocognitive disorder (SAND). Just like the HIV equivalent HAND, it comes in three stages: asymptomatic, mild, dementia. Same as after SARS 1, you wouldn’t have needed to see billions infected to know the basics.

@i_iratus

The Bear

2 months

Today I learned that I have completely underestimated and misunderstood brain-fog post COVID - and it is terrifying. In my mind I kind of had this impression that COVID brain-fog was just feeling a little bit forgetful or feeling very tired, and my god I was very, very wrong.

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Paul Maidowski

1 year

Good grief. We knew decades ago that human coronaviruses (here HCoV-OC43) are naturally neuroinvasive and neurotropic and associated with diseases like Alzheimer's. It wasn't necessary to infect billions of unwilling patients to find out, reading this paper would have sufficed.

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@vipintukur

Vipin M. Vashishtha

1 year

The key findings of this study are: 1-Brain infection via the olfactory pathway seems a common feature of coronaviruses, regardless of clinical disease presentations! 2-SARS-CoV-2 travels inside axons in in vitro neuron-epithelial networks. 6/

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Paul Maidowski

7 months

No sports for three months and limited exercise for the following three months after SARS-CoV infection. Not my advice - a leading cardiologist in Germany.

@BigBadDenis

Denis - The COVID info guy -

7 months

Healthy runner's stroke followed a bad bout of COVID-19. "She was still recovering from a serious bout of COVID-19, her third. All of this was unusual for Marshall, then 47 and in excellent health, thanks in part to running nearly every day."

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Paul Maidowski

2 years

“8% to 12% of vaccinated people with breakthrough infections may die due to long COVID.” Congrats @MeetJess , who compiled lists of #SpontaneousDeaths , journalists are beginning to listen. Now understand the scales: This may be a public health event unprecedented in human history.

@yaneerbaryam

Yaneer Bar-Yam

2 years

Strokes, heart attacks, sudden deaths: Does America understand the long-term risks of catching COVID? 1/

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Paul Maidowski

1 year

Fortunately I’m a rocket scientist, so here the public health decision every state worldwide now faces, broken down to its essence. Do you want to live with a SARS virus in your much shortened, disease-ridden lives or would you rather not? That’s the only real question here.

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Paul Maidowski

1 year

1. This is extremely funny because Martin was shocked by WHO reporting 1.5 million COVID-19 infections in the last 26 days worldwide. In reality, China alone accounts for 40-65 million infections *per week*. Check out Germany's updated excess mortality, the highest ever. Stabil.

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Paul Maidowski

4 months

SARS-CoV-2 reminder: The more immune compromised the population, the less symptoms, the ‘milder’ it appears, the more severe it really is (=Long Covid, long term damage). That’s what even most scientists seem not to get

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Paul Maidowski

9 months

Family friend, father of three, tested positive for Covid-19 once in summer 2022. Went on with an ambitious sport/vacation program because [horrible policy/scicomm]. Tested positive again a few weeks ago. Now in hospital as organs successively shut down. You can’t live with this

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Paul Maidowski

1 year

@NateB_Panic WHO said 1 in 10 infections, not 1 in 10 people. That's the key difference explaining why denial is no option.

@MarcusFitzsimon

@marcusfitzsimons.bsky.social Woke Green Socialist

@MarcusFitzsimon

1 year

@DrTedros *just* made a public announcement that *ONE in TEN *INFECTIONS* will lead to #LongCovid * not one in 10 people *ONE IN 10 INFECTIONS* this statement was just made, IE: POST VACCINES so WHY IS NO ONE MASKED Vaccines do NOT guarantee you will not suffer harm

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Paul Maidowski

6 months

Hybrid immunity was invented in 2021 to sell the idea of SARS-CoV-2 infections as a good. There is no literature pre 2021. The idea to infect the global population with a SARS virus, including all 2 billion children aged 14 yo and younger, didn't exist.

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@OhCasavant

Tracy Casavant Oh, BASc (Chml), MES

6 months

🧵 Is there hybrid immunity for measles like for COVID? If so, should that be a public health goal? Answer from Dr Mansour Haeryfur, President, Canadian Society for Immunology *Replying in a personal capacity, not on behalf of CSI or UWO

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Paul Maidowski

10 months

Persistent immune system dysregulation 18 years after ONE infection for tens of thousands of SARS survivors. Today it’s hundreds of millions. Truly unprecedented, mind blowing incompetence.

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Paul Maidowski

1 year

1. Sharing research on long-run sequelae in SARS-CoV-1 survivors 18 years post infection (there were no reinfections in Cov-1!), 14 HCW in Tianjin: "Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational study"

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Paul Maidowski

1 year

Did we try arresting some Climate protestors yet? That usually fixes it.

@US_Stormwatch

Colin McCarthy

1 year

New York City is currently experiencing its single worst day of air quality in recorded history, even worse then yesterday.

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Paul Maidowski

1 year

1. Simple policy like 'hygiene and pasteurization' doubled the human lifespan after 1889, stopping constant CoV outbreaks from milk. Simple policy like 'quarantine, isolation, N95 and international cooperation' ended SARS-CoV-1. We can end CoV-2. Don't halve the human lifespan.

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Paul Maidowski

2 years

My ancestor Arthur Schlossmann founded the world’s first pediatric clinic in Dresden in 1898, bringing infant mortality from >50% to 22%. This @UniklinikDUS is dedicated “To the savior of the children.” Don’t expose kids to SARS-CoV-2 in school/hospitals. It’s NOT inevitable. 1/k

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Paul Maidowski

2 years

Yes, (1) Prepare for an epidemic of cancer, beyond SAND (SARS-CoV-2 Associated Neurocognitive Decline). (2) It’s a systemic problem, the type western medicine + science love to ignore. It’s been VERY obvious to any systems thinker or outside observer. No one wanted to know. 🤦🏻‍♀️🤨

@Mark_Ungrin

Mark Ungrin

2 years

Yeah, just not liking this at all. Speaking with my professional network over the last while, it looks like the cancer people didn't know the virus does this, and the virus people didn't know what a big deal it is.

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Paul Maidowski

1 year

1. 9 young pilots died suddenly within 40 days. Wild because the article only talks about vaccines. It’s as if people are unable to face the fact that SARS-CoV-2 as vascular disease causes blood clotting and the types of deaths we see, more so AT HIGH ALTITUDE. Come on everyone.

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Paul Maidowski

1 year

How we do on “living with SARS-Co”? Nine pilots died in 40 days. Most in-flight.(?) For now aviation is a positive feedback, but eventually it’ll shift into a negative feedback. We mentioned high altitude is high risk for SARS survivors. Vascular disease.

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Paul Maidowski

2 years

1. Hundreds of millions of people now live with replicating SARS virus in their skull marrow and brain tissue. Congrats, this is the “Living with Covid” world you wanted. How exactly do they plan to fix population-wide neurocognitive decline?

@vipintukur

Vipin M. Vashishtha

2 years

The persistence of the spike protein in the skull marrow and brain tissues even after recovery from COVID-19 raises questions about the potential long-term effects of the virus on neurological health.

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Paul Maidowski

9 months

— "Dad, what's the most common Long Covid symptom?" — "Don't know and don't care, son"

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Paul Maidowski

3 years

Only four climate scientists have +100k followers. Yesterday @SaraSchurmann suggested making @rahmstorf the fifth, and it’s going strong. Let’s add @KevinClimate as #6 , he’s among the most persistent voices. Why it’s necessary: #IPCCReport already vanished from the headlines 😬

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Paul Maidowski

2 years

See how the Arctic is burning and melting, with extraordinary heat perennially present in Siberia. All this will inevitably go - the ice within years. Few economists, lawyers & politicians understand what is at stake. They literally can't. No one taught them to think differently.

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Paul Maidowski

1 year

Excess mortality is increasing or not falling in most countries most of the time. This is not normal. In a few years you'll see what watershed in human history SARS-CoV-2 caused. It's a political choice. In 2003, states decided against "Living with SARS." They could do it again.

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Paul Maidowski

10 months

1. Bacteriophage-like: "Our results strongly suggest interactions with bacteria in intestinal microbiota. SARS-CoV-2 can enter the cells of bacteria that are part of the normal human gut microflora and synthesize both RNA and viral peptides. Important etc.

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Paul Maidowski

3 years

"I'm telling you that we're putting our kids onto a global school bus that will with 98% probability end in a deadly crash." —Schellnhuber, saying what leaders don't want to admit. 1/2

@visevic

Danijel Višević

3 years

"Ich sage Ihnen, dass wir unsere Kinder in einen globalen Schulbus hineinschieben, der mit 98% Wahrscheinlichkeit tödlich verunglückt." Hans Joachim Schellnhuber, Gründer des Potsdam-Instituts für Klimafolgenforschung (PIK)

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Paul Maidowski

3 years

People keep talking about climate policy as if they didn't understand what is at stake: their lives, freedoms, democracy, civilization.

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Paul Maidowski

1 year

Anyone who has lived in Brooklyn - or any dense US city - knows how much concrete there is everywhere. They don’t even pave their pavements, its just water-impenetrable concrete as pavement. Modern civilization is so unprepared for what’s coming 😢🫠

@notcapnamerica

chris evans

@notcapnamerica

1 year

Park Slope, Brooklyn right now 😳

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Paul Maidowski

1 year

1. Sharing research on long-run sequelae in SARS-CoV-1 survivors 18 years post infection (there were no reinfections in Cov-1!), 14 HCW in Tianjin: "Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational study"

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Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational...

Although health outcomes continued to improve, our study suggested that SARS survivors still suffered from physical fatigue, osteoporosis, and necrosis of the femoral head 18 years after discharge,...

www.thelancet.com

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Paul Maidowski

9 months

Correct. It was known before the pandemic started that human coronaviruses are naturally neuroinvasive, neurotropic, and associated with MS, AD, PD, sCJD *10-15 years after infection*. Excellent 2019 review. This is coming, as we’ve been warning for years.

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Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the...

Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individ...

@DaniBeckman

Danielle Beckman

9 months

Not only EBV (Epstein–Barr virus) is correlated to the development of Multiple Sclerosis (MS), coronaviruses as well. Actually, one of the most studies effects of coronaviruses on the brain is related to its connection with MS, the most common demyelinating disease in humans.

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Paul Maidowski

1 year

I don’t say this often or lightly. Vinay Prasad is one of those truly evil persons. Being deluded is no excuse anymore as we enter year five of a SARS pandemic. I need journalists worldwide to develop basic science literacy.

@NateB_Panic

Nate Bear

1 year

Prasad has mocked people with long covid, appeared to suggest the condition is a delusion, said no one should test for covid any more, and said research into long covid only delivers "fear"

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Paul Maidowski

2 years

My ancestor Arthur Schlossmann founded the world’s first pediatric clinic in Dresden in 1898, bringing infant mortality from >50% to 22%. This @UniklinikDUS is dedicated “To the savior of the children.” Don’t expose kids to SARS-CoV-2 in school/hospitals. It’s NOT inevitable. 1/k

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@Peine01

H.P.

2 years

Arthur Schloßmann (16. Dezember 1867 -5. Juni 1932) war Pädiater und Gründer der weltweit ersten Klinik für kranke Säuglinge in Dresden 1898. Er erforschte Säuglingskrankheiten und widmete sich allen Fragen der Hygiene, die für das Kindeswohl wichtig sind.

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Paul Maidowski

1 year

The west is deep in denial. It deeply disturbs me as systems scholar. The forces of denial won; now even scientists ask what ‘the next’ pandemic is. Friends, it’s right here. Beta-CoVs evolved perfectly to establish chronic infectio. It just takes years for damage to accumulate.

@vipintukur

Vipin M. Vashishtha

1 year

‘As the COVID-19 pandemic threat seemingly fades into the annals of history, scientists are attempting to identify which pathogen will pose the next large-scale threat to humanity’ 1/

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Paul Maidowski

9 months

Point is if you’re a sport person, force yourself to not add immunological injury to viral insult. Take it easy for 3 to 6 months. Ideally spend some quality time reading up on coronaviruses and how to stop them. 👍

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Paul Maidowski

2 years

Next we need to retire the term “breakthrough infection.” Vaccines were not designed to prevent infection, but have been sold as such to the public. People don’t even know they’re at risk. The global pandemic response has been a show of incompetence and unfounded optimism.

@fitterhappierAJ

AJ Leonardi, MBBS, PhD

@fitterhappierAJ

2 years

Correct. Preventing long covid was not part of the vaccine’s objective.

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Paul Maidowski

1 year

1. This is extremely funny because Martin was shocked by WHO reporting 1.5 million COVID-19 infections in the last 26 days worldwide. In reality, China alone accounts for 40-65 million infections *per week*. Check out Germany's updated excess mortality, the highest ever. Stabil.

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@MartinStamer

Martin Stamer

1 year

Mein Tweet "Covid ist vorerst Geschichte" war ein großer Irrtum ! Eine Mail der WHO von gestern, die ich heute erst zur Kenntnis genommen habe, hat mich mit berichteten 1,5 Mio (!) neuen Fällen und 7.300 Covid-Toten der letzten 26 (!) Tage schockartig aufgeweckt #CovidisNotOver

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Paul Maidowski

3 years

Years ago there was a discussion about collapse. We call it uncontrolled loss of social complexity or simplification, but that is so abstract. Kind people asked what it looks like. The world’s richest country letting a virus ravage its own population, this is what it looks like.

@nprpolitics

NPR Politics

3 years

Research into next-generation COVID vaccines will be curbed, and some surveillance for new variants will also be stopped, the White House said. The administration said it also will need to limit its push to help poorer countries vaccinate people.

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Paul Maidowski

14 days

According to 95% of MDs quoted in the media, the cause is not the neuroinvasive sarbecovirus, but 6 weeks of not going to the pub in 2020 - especially in toddlers not yet conceived at the time 👍

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Paul Maidowski

14 days

6. "In this review, we summarize the mechanisms by which SARS-CoV-2 invades and destroys the CNS, aside from the immune response and inflammatory storm." 🧠🍳🤷‍♂️

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Paul Maidowski

8 months

3 in 10 now have mild or severe brain damage from Covid AND mild ones can’t tell since they don’t notice themselves. You guys could have known this from SARS-CoV-1, it’s no surprise whatsoever. But you wanted to not learn it yourselves. So now we decarbonize slowly the viral way.

@EricTopol

Eric Topol

8 months

Key simple graphic comparing objective cognitive testing results for Long Covid (PCC) individuals vs those with COVID but no chronic sequelae (no PCC) and healthy controls (No COVID)

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Paul Maidowski

3 years

Wow, thanks! @bberwyn pulls off a rare feat: not to repeat a pattern that most IPCC articles follow. He cuts to the heart. With deep gratitude to IPCC colleagues for their difficult work, @ClimateHuman and I kindly call for an uprising and new economics.

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Paul Maidowski

2 years

@fitterhappierAJ There will be no ill wishes from my side even for the worst minimizers, but they leave us a major problem. If they choose not to learn from scientific observation or others’ experience, the can only learn from personal experience.

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Paul Maidowski

6 months

Good thread if you follow Covid science. How Dr. Leonardi is being treated for prescient, mostly accurate warnings and scientific argument senior scholars failed to see is concerning. PhDs tend to know their own narrow field extremely well; it would be smart to pay attention.

@gemcarey

Prof Gemma Carey, PhD MMedSci

6 months

So @fitterhappierAJ published his PhD? work during his time at a research institution - while done before the pandemic, a novel virus came along that his PhD spoke to . It found its niche. This tends to happen with PhDs... it also tends to happen some time after you finish them

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Paul Maidowski

3 years

@ianbremmer The stable climate structure of the past is breaking down. Time for everyone to start to grow food and learn what’s ahead.

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Paul Maidowski

8 months

Is the pandemic over? - Update on the rocket science:

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Paul Maidowski

1 year

Fortunately I’m a rocket scientist, so here the public health decision every state worldwide now faces, broken down to its essence. Do you want to live with a SARS virus in your much shortened, disease-ridden lives or would you rather not? That’s the only real question here.

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Paul Maidowski

1 year

The public was sold out, by scientists and the media who failed to do their jobs. The word ‘hybrid immunity’ didn’t exist before 2021.

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Paul Maidowski

2 years

Just to confirm: 'Hybrid immunity' is another of these terms invented to legitimize NOT preventing infection (thereby harming billions). The term didn't exist before 2021.

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Paul Maidowski

1 year

A policy of living with SARS-CoV means the virus will ‘live within each of us.’ It means immunodeficiency, cancer and slow, inevitable societal decline. This is how modern civilization ends itself.

@Mr_Inquisitr

If I may...

1 year

@JeromeAdamsMD Jerome, you’re doing good work. But the direction + accumulating intensity of research calls for significant further escalation: We are heading towards a future not of ‘living with’ the virus, but where the virus ‘lives within each of us.’ You know the implications of this

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Paul Maidowski

2 years

This is the level of Covid information the Taiwanese government sends to your smartphone every morning. Whatever the west’s (not) doing is pathetic in comparison. I guess most westerners just don’t know there is a world that’s different out there, else they’d demand better. 😈🤦🏻‍♀️

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@DoropFan

すみたちいちろう

2 years

中国🛫 - 台湾🛬 BA.5.1* 1 BA.5.2* 96 BF.7* 58 BQ.1* 2

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Paul Maidowski

2 years

Life expectancy will equal retirement age. It’s what living with COVID always meant. Lol

@DrJohnHhess

John Hess MD

2 years

Anyone else find it disturbing that many in the US are advocating for raising the retirement age? What about this chart makes anyone think there is going to be a big jump in life expectancy in the future? Flat from 2010 on even prior to the pandemic. Universal health care anyone?

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Paul Maidowski

2 years

My entire timeline right now: 😂👇 Probably my favorite part is how Lauterbach says “if you notice incurable immune deficiency after two infections, try to avoid a third” We need to rediscover policy as the art of shaping society. Or rediscover the precautionary principle. 🤗

@EnemyInAState

Chris Turnbull

2 years

EXPLOSIVE ADMISSION: German Health Minister warns that Covid causes incurable immune defiency...or as we we call it Covid acquired immune deficiency syndrome — CovidAids.

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Paul Maidowski

9 months

The anti vaccine crowd has found this tweet apparently. I block and hide particularly idiotic tweets, because I provide no platform for any-science anti-health disinformation. No rocket scientist was harmed in this tweeting.

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Paul Maidowski

4 years

@ennopark Danke! Kluger thread. Covid19 durch Klimakrise ersetzen & es passt ebenso exakt, nur noch viel existentieller wegen der globalen Dimension. Unsere politischen Systeme sind von komplexen systemischen Problemen überfordert, aber kaum wer findet die Sprache, die Probleme zu benennen

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Paul Maidowski

3 months

Human coronaviruses including SARS-CoV-2 are naturally neuroinvasive and neurotropic. Educators, it’s not “protections during the pandemic” whose impacts you see, but population level, ongoing, completely unmitigated brain damage. 🤷‍♂️ 🤷🏻‍♀️

@aldenejones

Alden Jones

3 months

Yes, college students have lost their ability to read. I have taught lit for 24 years; the threshold started to decline in the late aughts and nosedived during Covid. A thread with observations + how I get my students to read ALL (or at least most) of the reading I assign: 🧵

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Paul Maidowski

1 year

2. Recovered SARS patients had a poor quality of life 12 years following recovery, susceptible to inflammation, tumors, glucose and lipid metabolic disorders. For the 12-year study they recruited 25 SARS survivors; for the 18-years only 14, ironically due to COVID restrictions.

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Paul Maidowski

1 year

Let me translate what AJ is saying. Western societies failed, letting populist, science-illiterate leaders dominate pandemic policy when epidemiologists were needed. You are now decarbonizing yourselves. 🥴🤌 This is sad, serious and was foreseeable and foreseen by us Jan 2020.

@fitterhappierAJ

AJ Leonardi, MBBS, PhD

@fitterhappierAJ

1 year

It is of urgent social importance to determine the rate of labor attrition on Long Covid caused by reinfection Because reinfections average 2-3x per year If 5% of those infected remain out of the labor force for at least one year, workers will dwindle

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Paul Maidowski

10 months

US CDC recommends N95 masks and ventilation? NOW I'm worried 🤣🤣

@CDCDirector

Mandy K. Cohen, MD, MPH

10 months

Virus season is here! Hear the latest.

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Paul Maidowski

1 year

Is the pandemic over? No, worse than ever. We just stopped testing. I call SARS ‘the Unthinkable’, after @GhoshAmitav , who coined the term for climate, a phenomenon equally culturally unthinkable. Bangalore has some 11 million people There’s no need to be this irresponsible.

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Paul Maidowski

1 year

Kind reminder that SARS is not novel and that giving it a new name (‘Covid’ ‘Corona’ 新型冠状病毒) just distracted 99% of people from the fact that we have 15-18 year SARS survivor studies. This is as non-novel as pandemics get.

@_ppmv

Paul Maidowski

1 year

1. Sharing research on long-run sequelae in SARS-CoV-1 survivors 18 years post infection (there were no reinfections in Cov-1!), 14 HCW in Tianjin: "Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational study"

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Paul Maidowski

3 months

Crucial information that cannot be denied any longer. Covid and Long Covid are marked by viral persistence of various timescales, from months to years in the gut. This is not “the vaccine” 😂 but active #viral replication and CAN forward transmit.

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@polybioRF

PolyBio

3 months

Breaking!: Research published today in Science Translational Medicine and supported by PolyBio Research Foundation shows that the #SARS -CoV-2 virus can chronically persist in the gut of patients with long COVID for over 2 years:

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Paul Maidowski

1 year

Did we arrest some climate activists recently? That usually fixes it

@zakkumec

KASİDE

1 year

After Hurricane Otis made landfall in Acapulco.

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Paul Maidowski

1 year

HIV infected 85 million over 40 years, 40 million died ( + 670,000 per year), there is a viral load test and effective ART. SARS-CoV infected 6-7 billion in 4 years, some 30 million died (+ 1-3 million per year?). It amplifies all other pathogens, including HIV.

@AuDHDeep1

AuDHDeepThought - audhdeepdive.bsky.social

1 year

"HIV is nothing like SARS, SARS is airborne and everybody has already had it like three times!"

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Paul Maidowski

2 years

Climate change is the Unthinkable, a problem of language and law. As SARS-CoV-2 will show, those elected to avert disaster lack the training to do so. Our challenge is to learn to think (and apparently, lead) in a finite world. Learn fast, be well 🙏☕️.

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Paul Maidowski

2 years

See how the Arctic is burning and melting, with extraordinary heat perennially present in Siberia. All this will inevitably go - the ice within years. Few economists, lawyers & politicians understand what is at stake. They literally can't. No one taught them to think differently.

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Paul Maidowski

10 months

How long no sports after SARS-CoV-2? “3 months none, then the next 3 months little sport.” That’s not me reading some article, but an experienced MD few patients will be lucky enough to ever meet saying it. - You see how “2-3 COVID-19 infections per year” is unsustainable policy.

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Paul Maidowski

1 year

Fever is no main symptom of new SARS variant EG.5.1. That’s bad - harder to test & trace. The immune system becomes permissive, allowing SARS chronic infection. Expect more bacterial, fungal, other viral infection.

@Yash25571056

Hiroshi Yasuda (保田浩志)

1 year

"[The main symptoms of the new Omicron strain EG.5.1] are a sore throat, a runny nose, a blocked nose, sneezing, a cough without phlegm, a headache, a cough with phlegm, a hoarse voice, muscle aches and pains and an altered sense of smell.. However, shortness of breath, a loss

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Paul Maidowski

11 months

One of the popular myths of SARS is that the virus kills. No it doesnt; it even extends (!) the lifecycle of the cell, a common strategy employed by cancers and other viruses. People should really read human coronavirus science. We’re deep in trouble. 🤷🏻‍♀️🤷‍♂️☕️

@RajeevJayadevan

Rajeev Jayadevan

@RajeevJayadevan

11 months

New mechanism of brain damage uncovered, following SARS-CoV-2 infection. I discuss in today’s @the_hindu Newspaper 🗞️ Science Page @RPrasad12 Link to study below 👇

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Paul Maidowski

2 months

1. SARS-CoV-2 changes the host chromatin (=DNA and protein mix) via the nucleocapsid, Orf8, Orf10 IF expressed, and further viral proteins. HIV-1 Tat behaves similarly. In simple words, Covid-19 reprograms the host's mitochondrial metabolism and epigenome.

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Paul Maidowski

10 months

We have a lightning fast new SARS-CoV variant with key nucleocapsid mutation N:Q229K, but there is absolutely no discussion whatsoever? Can this be true?

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Paul Maidowski

2 years

1. The SARS-CoV-2 nucleocapsid can mediate RNA or DNA entering cells by ACE2-independent, receptor mediated endocytosis, and express genes. It is enhanced by RANTES (CCL5), a chemokine induced by N, and lactate, produced in hypoxia, to cause more damage.

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Paul Maidowski

2 years

1. The SARS-CoV-2 nucleocapsid can mediate RNA or DNA entering cells by ACE2-independent, receptor mediated endocytosis, and express genes. It is enhanced by RANTES (CCL5), a chemokine induced by N, and lactate, produced in hypoxia, to cause more damage.

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Paul Maidowski

9 months

Anti-vaccine disinformation has broken many people’s minds. I mention two documented SARS infections here and nothing about vaccines, yet anti-vaccine folk invariably jump to “it’s the vaccine”. The virus found the weak, sweet spots in society. Fascinating

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Paul Maidowski

1 year

The future belongs to societies that protect their children. It’s as simple as that.

@DrPops3

Dr Kelly Jones #cleanairclassrooms

1 year

Thailand- kids need to send in Covid test results every Sunday to start the school week as well as wear N95 in class. I need to move

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Paul Maidowski

1 year

2. "Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection" - Many good studies barely anyone read, and we shared them as volunteers on twitter like raw meat at a vegetarians' annual congress.

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Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection

Scientific Reports - Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection

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Paul Maidowski

1 year

Where are all our "Prepare for the next pandemic" friends, now that the next pandemic is here? They had no trouble ignoring the direct link between SARS-CoV-1 and -2, so it should be no trouble at all to treat BA.2.86 as a new pandemic. Serological distance is the same.

@UseBy2022

Future

1 year

Alexa, show me what sampling microclusters look like please. I'm still just totally fucking gobsmacked by how lightly people are treating BA.2.86, ya know as if it's nothing when it almost puts you back to square one. Stupid twats. What in God's name is wrong with you all 😂.

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Paul Maidowski

10 months

1. SARS-CoV and prion disease (PrD): Will do a thread just as soon as I can scrape my chin off the floor. Dr. Laura Manuelidis starts high and goes hard sentence for sentence

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Paul Maidowski

2 years

Newer study by the same author, @zalaly . - To draw on the vast existing literature, we propose using SARS-CoV-2 associated neurocognitive damage (SAND), in parallel to the HIV equivalent (HAND). We’ve been saying this for a while now, we’re rapidly running out of time.

@zalaly

Ziyad Al-Aly, MD

2 years

The latest from our team in @NatureMedicine The long-term neurologic consequences of #COVID19 A thread 🧵 by @evanjxu @Biostayan @zalaly

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Paul Maidowski

1 year

“Azvudine could concentrate in the thymus with its active form after oral administration, inhibit the replication of SARS-CoV-2 in vivo, and protect the immune function of the thymus.” Remarkable, published in May. No one but us seems to tell the public. ?

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Oral Azvudine for hospitalised patients with COVID-19 and pre-existing conditions: a retrospective...

These findings indicate that Azvudine therapy showed substantial clinical benefits in hospitalised patients with COVID-19 and pre-existing conditions, and should be considered for this population of...

www.thelancet.com

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Paul Maidowski

1 year

This 2020 preprint is now published. Peer review took three years! - okay but not new: SARS-CoV-2 uses CD4 to infect T helper lymphocytes

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SARS-CoV-2 uses CD4 to infect T helper lymphocytes

The infection of T helper lymphocytes by SARS-CoV-2, mediated via the CD4 molecule, alters cellular function and enhances expression of the anti-inflammatory cytokine IL-10, potentially impairing...

elifesciences.org

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Paul Maidowski

15 days

1. The structural parallels of SARS-CoV-2 and HIV-1 were known already 20 years ago, from SARS-CoV-1. Yet COVID-19 policy and even most scientists ignore these parallels, failing to learn key lessons. Fundamentally, genetic recombination drives both pandemics—two typical articles

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Paul Maidowski

1 year

2. SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence. The virus damages your DNA AND DNA repair. I bet this one will be highly popular.

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Paul Maidowski

4 months

Western science and education are wholly unprepared for the dynamics and complexity of SARS-CoV-2 population level effects. Interesting years ahead,

@vipintukur

Vipin M. Vashishtha

4 months

These findings highlighted the systemic nature of SARS-CoV-2 infection, emphasizing the need for comprehensive clinical management strategies and targeted therapeutic approaches beyond respiratory systems. 6/6

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Paul Maidowski

1 year

1. We enter the strange transition period before population-wide damage from SARS-CoV-2 hits. GPs/gynecologists now trivialize pre/perinatal COVID-19 infection because they don't read science. Share research to help them learn. Maternal chronic immune activation harms the embryo.

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Paul Maidowski

2 years

Did anyone summarize gynecologist views on the risk of acute or previous SARS-CoV-2 inf in pregnancy to mother &/or unborn? “Most of my patients last year had COVID and they were all fine”, one told me. Not my role to argue her ofc, but it doesn’t match the studies I’ve seen. 😫

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Paul Maidowski

2 years

@ejustin46 @siamosolocani @RadCentrism @mrmickme @wolfeagle1989 @dfocosi @DavidJoffe64 @RealCheckMarker Here a cohort study of 18-year sequelae in SARS survivors, 14 HCW in Tianjin. We can - roughly - argue what's ahead in the next 18 years! Priority to me: stopping transmission. But this won't be politically possible until the scientific basis is clearer.

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Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational...

Although health outcomes continued to improve, our study suggested that SARS survivors still suffered from physical fatigue, osteoporosis, and necrosis of the femoral head 18 years after discharge,...

www.thelancet.com

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