PolyBio @polybioRF Twitter profile | Pikagi

Pikagi

PolyBio

@polybioRF

11,090

Followers

2,165

Following

114

Media

1,646

Statuses

501(c)3 transforming how #LongCovid , #ME /CFS & Lyme+ are studied, diagnosed, and treated. Leading the #LongCovid Research Consortium.

United States

https://t.co/uzxFcJBGwM

Joined October 2020

Don't wanna be here? Send us removal request.

Pinned Tweet

@polybioRF

PolyBio

2 years

PolyBio Research Foundation is excited to be leading the #LongCovid Research Consortium: a scientific collaboration between top global research teams to rapidly & comprensively study LongCovid, with a focus on the topic of SARS-CoV-2 persistence in tissue:

Tweet card media

LongCovid Research Consortium (LCRC) - PolyBio Research Foundation

25

135

452

Last Seen Profiles

@nbuethe

@wmag

@Ladyd08181990

@ninioanarco

@Ahmet_K_Han

@moanrosa

@CiciCic22125505

@Dolemite_1975

@IVAN_GAI_140308

@herts_golf

@Blitz_DotA

@AQuartiroli

@renjerwaluh

@VirgoddessG

@veeyusschi

@DeadKingSociety

@cloud_capital

@spxtra69

@jndoIIs

@Kangacollins123

@bbcprincess84

@AgnesCallamard

@karate_soVR46

@rachel_schwartz

@saikoujime26614

@elhajalisherine

@unclephilslocks

@Carter4Boone

@Junathan_Tirol

@prodskywide

@bc_renew

@SmallITALIANMN

@BxTadow

@XNVL_Yuhma

@GeorgiaBClark

@Ada_Daddyya

@polybioRF

PolyBio

2 months

Breaking!: Research published today in Science Translational Medicine and supported by PolyBio Research Foundation shows that the #SARS -CoV-2 virus can chronically persist in the gut of patients with long COVID for over 2 years:

Tweet card media

Chronic virus found in long COVID gut up to 2 years post-infection - PolyBio Research Foundation

Team famous for HIV breakthroughs demonstrates both persistent COVID virus and widespread immune activation in long COVID; provides clear targets for...

49

757

2K

@polybioRF

PolyBio

2 years

Huge news! We received ~1.3M from Balvi ( @VitalikButerin ) for a study of #LongCovid intestinal tissue w/ @MehandruLab , @PutrinoLab & @drmfreire . We will use cutting-edge technologies to identify SARS-CoV-2 + immune/microbiome abnormalities in samples:

Tweet media one

79

211

851

@polybioRF

PolyBio

6 months

We are excited to announce a 2nd series of collaborative projects & clinical trials supported via our LongCovid Research Consortium:

Tweet card media

New LongCOVID research launched by PolyBio’s global consortium of scientists - PolyBio Research...

Funding will deepen research on the persistence of the SARS-CoV-2 virus in LongCOVID patients and launch new clinical trials Medford MA,...

40

300

836

@polybioRF

PolyBio

10 months

We are excited to share that @MBVanElzakker & team at @MGHMartinos have published a preprint with the results of a high-resolution #LongCovid imaging study. They identified neuroinflammation across a wide range of brain regions in LongCovid patients:

30

331

793

@polybioRF

PolyBio

1 year

PolyBio is excited to be leading the LongCovid Research Consortium (LCRC): a global scientific collaboration to rapidly & comprehensively study #LongCovid disease mechanisms, with a focus on SARS-CoV-2 reservoir (). LCRC projects we are supporting include:

Tweet card media

LongCovid Research Consortium (LCRC) - PolyBio Research Foundation

33

296

741

@polybioRF

PolyBio

1 month

We are excited to have supported this new study via our #LongCovid Research Consortium. The project team are our incredible @CUBoulderBN colleagues at the University of Colorado Boulder:

Tweet media one

14

282

749

@polybioRF

PolyBio

3 years

We are very excited to annouce that thanks to the generous support of 3 private donors, we are able to begin our CCI and Structural 7-Tesla Imaging Project in patients w/ complex chronic illness ( #ME /CFS, #LongCovid , #EDS etc)

36

152

642

@polybioRF

PolyBio

22 days

PolyBio Research Foundation is excited to announce a $1M donation to UCSF. The donation will allow the UCSF LIINC team to study #ME /CFS patients with advanced technologies, several of which have never yet been used in the field:

Tweet media one

21

214

619

@polybioRF

PolyBio

10 months

We are excited to announce a $15M gift from Kanro: a philanthropic fund to support scientific research established by Vitalik Buterin, co-founder of Ethereum:

Tweet card media

PolyBio Research Foundation receives $15M for extended Long COVID research and clinical trials

PolyBio Research Foundation has announced a $15M gift from Kanro: a philanthropic fund to support scientific research established by Vitalik Buterin, co-founder of Ethereum. The funding will support...

finance.yahoo.com

28

156

579

@polybioRF

PolyBio

1 month

2/ The findings suggest that multiple infectious “hits” ( #viral and #bacterial ) may amplify long-term neuroinflammatory or neuroimmune symptoms in patients with #LongCovid .

6

132

505

@polybioRF

PolyBio

4 months

We are proud to have supported this new paper published in @BrainBehavImm . Led by @MBVanElzakker & team at @MGHMartinos , it is the is first study to document neuroinflammation in the long COVID brain along with evidence of vascular problems:

Tweet card media

LongCOVID brain inflammation associated with vascular problems, Harvard team finds - PolyBio...

Neuroinflammation was identified across a wide range of brain regions and connected to measures of blood vessel dysfunction (Medford MA, May...

16

198

506

@polybioRF

PolyBio

6 months

1. Icahn School of Medicine Mount Sinai: “A clinical trial of repurposed HIV antivirals in LongCOVID” 👉 Learn more here:

Tweet card media

A clinical trial of repurposed HIV antivirals in LongCOVID - PolyBio Research Foundation

Project Summary: A clinical trial to test if two repurposed HIV antivirals (Truvada and Maraviroc) can reduce symptom burden in patients with...

16

131

471

@polybioRF

PolyBio

25 days

Good article in Bloomberg on our PolyBio/Sinai/Yale trial of repurposed HIV antivirals in LongCovid:

Tweet media one

10

143

434

@polybioRF

PolyBio

5 months

We recognize the urgent need to trial more antivirals in #LongCovid . We are working w/ @PutrinoLab + @VirusesImmunity on this Truvada/Maraviroc trial. The drugs will be trialed individually first: The trial is not yet enrolling but we will keep you posted

Tweet card media

A clinical trial of repurposed HIV antivirals in LongCOVID - PolyBio Research Foundation

Project Summary: A clinical trial to test if two repurposed HIV antivirals (Truvada and Maraviroc) can reduce symptom burden in patients with...

@sun_in_winter12

Christy Collins 🍉 🕊️

@sun_in_winter12

5 months

Just met with a doctor who's prescribing me multiple antivirals for #longcovid . Beyond disgusted with our govt for providing no warning and no treatments. Honestly I urge anyone considering antivirals to start now. My doc said I might have made things worse by waiting.

79

213

1K

26

110

420

@polybioRF

PolyBio

11 months

Great article about the new UCSF #LongCovid monoclonal antibody clinical trial geared at clearing #SARS -CoV-2 reservoirs. We have committed funding to support the experimental medicine portion of the trial which includes key viral persistence measurements:

Tweet card media

UCSF is trying a new tactic to eradicate long COVID symptoms. Here’s how it works

S.F. researchers are the first to try infusions of monoclonal antibodies to vanquish...

www.sfchronicle.com

9

103

368

@polybioRF

PolyBio

1 month

3/ More specifically, the team showed that brain exposure to a #SARS -CoV-2 spike protein subunit drove a long-term vulnerability not only to #neuroinflammation , but also to forms of autonomic dysregulation such as increased heart rate and core body temperature.

6

87

353

@polybioRF

PolyBio

2 months

3/ Long COVID is not a mystery” says UCSF's Michael Peluso MD, who co-led the study. “Our findings provide clear evidence of #virus persistence and sustained immune activation after #COVID -19. We must use this information to test treatments that might get people better.”

6

85

351

@polybioRF

PolyBio

5 months

Great to see this new piece in @ScienceMagazine highlighting LongCovid clinical trials working to target #SARS -CoV-2 persistence. We are proud to be supporting nearly all the teams/trials mentioned in the piece via our LongCovid Research Consortium:

Long Covid trials aim to clear lingering virus—and help patients in need

With a still-emerging understanding of the syndrome’s biology, researchers are braiding basic discoveries into treatment studies as they go

www.science.org

3

113

338

@polybioRF

PolyBio

10 months

@UCSFMedicine 13/ Mount Sinai’s Cohen Center for the Recovery from Complex Chronic #Illness (CoRE) will also add HEPA filters and germicidal UV devices to its building to clear airborne viruses & other aerosols from the air, and require N95 respirator use and COVID PCR testing from its staff.

7

67

334

@polybioRF

PolyBio

3 years

Great news! A generous donor has made a $250,000 donation to PolyBio. The funding will let us collect key early data for several of our projects 🙏 We are incredibly thankful + more motivated than ever to study root cause drivers of #MECFS , #LongCovid etc!

PolyBio Research Foundation - Science in Action!

18

52

318

@polybioRF

PolyBio

8 months

PolyBio is glad to have supported this Nature Immunology paper showing #LongCovid immune dysregulation connected to potential #SARS -CoV-2 tissue reservoirs. Learn more about the findings here:

Tweet card media

PolyBio-supported team publishes Nature Immunology paper showing LongCovid immune dysregulation...

(Medford MA, January 11, 2023) – PolyBio is excited to announce that a study supported by its LongCovid Research Consortium was published...

9

105

299

@polybioRF

PolyBio

1 month

5/ Neuroimmune ‘priming’ is an effect by which subsequent #immune challenges – such as several infections in a row – can cause increasingly profound and protracted #neuroinflammation ,” said PolyBio co-founder and neuroimmunologist Dr. Michael VanElzakker.

1

40

282

@polybioRF

PolyBio

2 months

2/ The findings, published by a UCSF team known for innovation in HIV research, also documented T cell immune activation across the bodies and brains of people after COVID. This T cell activation was particularly elevated in the spinal cord and gut wall of long COVID participants

Tweet media one

1

57

277

@polybioRF

PolyBio

1 year

PolyBio is proud to have supported this new study by @MichaelPelusoMD & team. They identified tissue-based T cell activation in body sites such as brainstem/bone marrow + #SARS -CoV-2 RNA persistence in colorectal tissue up to 2 years post-COVID-19:

Tweet card media

Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for...

The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms (Long COVID) following SARS-CoV-2 infection are incompletely understood. There is growing evidence that viral...

www.medrxiv.org

9

88

270

@polybioRF

PolyBio

1 month

6/ This means that multiple inflammatory challenges can add up to be greater than the sum of their parts.

2

28

267

@polybioRF

PolyBio

1 month

Together, these observations suggest that even clinically mild infection could have long-term consequences on tissue-based immune homeostasis and potentially result in an active viral reservoir in deeper tissues." 👇

Tweet card media

COVID's Hidden Toll: Full-Body Scans Reveal Long-Term Immune Effects

Even in those without long COVID.

www.sciencealert.com

4

113

263

@polybioRF

PolyBio

5 months

Excited to announce the PolyBio Spring Symposium. It will take place online May 17 from 12 -5 pm ET. Join to hear PolyBio-supported investigators give short updates on their projects. Register here:

Tweet media one

2

126

262

@polybioRF

PolyBio

23 days

Yes enough already! These leads on #LongCovid disease mechanisms are HUGE, which is why we’re doing everything in our power to support the team moving forward

@cjmaddison

Chris J. Maddison

24 days

Enough already: T cell inflammation and SARS-CoV-2 virus persist in Long Covid. Editor's choice in @ScienceMagazine Immunology from Friday.

7

179

495

9

77

260

@polybioRF

PolyBio

10 days

PolyBio is excited to be supporting this new project by Nadia Roan & team at UCSF. The study is analyzing endometrial biopsy tissue to improve our understanding of the mechanisms underlying long COVID in women:

Tweet card media

SARS-CoV-2 persistence & T cell activity in the female reproductive tract - PolyBio Research...

Project Summary: A project to test the hypothesis that the female reproductive tract is a preferential site of SARS-CoV-2 persistence and/or...

8

98

269

@polybioRF

PolyBio

1 month

9/ They also show that problems like #autonomic dysfunction and #hormonal imbalances in long Covid can be directly connected to #environmental insults and exposures.

3

32

254

@polybioRF

PolyBio

1 month

4/ The research – conducted in rats – also found that S1 protein induced a considerable decrease in cortisol hormone levels in a #brain region called the hippocampus. This process may be related to some teams’ findings of low cortisol #hormone levels in patients with LongCovid.

2

25

248

@polybioRF

PolyBio

1 year

3. University of California San Francisco: “Use of total-body PET #imaging to identify deep-tissue SARS-CoV-2 reservoirs and T cell activity in Long COVID” 👉 Learn more here:

Tweet card media

Total-body PET imaging to identify deep-tissue SARS-CoV-2 reservoirs in Long COVID - PolyBio...

Project Summary: This study is the first in the world using advanced imaging technologies to identify deep tissue SARS-CoV-2 reservoirs in...

6

44

238

@polybioRF

PolyBio

2 months

5/ Post-COVID study participants showed increased T cell activation in sites across the brain and body, including the #brain stem, bone marrow, cardiac tissues, and the #gut wall compared to people who were never infected with the virus.

Tweet media one

5

36

236

@polybioRF

PolyBio

1 month

8/ The findings suggest that treatment protocols identifying and addressing different #infectious or #inflammatory insults in patients with long COVID or related conditions may be needed to manage symptoms.

2

29

234

@polybioRF

PolyBio

2 years

We want to give a special shoutout to @cstroeckw and family who were one of the donors for this project. They were so generous and kind with their willingness to help make the research happen! 🙌

@microbeminded2

Amy Proal, PhD

@microbeminded2

2 years

So it turns out we did find “something in the blood” of #ME /CFS patients: fibrinaloid microclots + hyperactivated platelets (that you can see with your own eyes). Thank you so much to @polybioRF donors who helped support part of the study:

Tweet media one

Tweet media two

Tweet media three

120

900

3K

11

31

229

@polybioRF

PolyBio

2 years

“One core question is: Do these microclots actually represent a root cause, or are they in response to something else that's ongoing?” says Michael VanElzakker PhD, co-founder of PolyBio Research Foundation, which is focused on studying viral reservoir:

Tweet card media

Coronavirus (COVID-19) Overview

COVID-19 is a new type of coronavirus that causes mild to severe cases. Here’s a quick guide on how to spot symptoms, risk factors, prevent spread of the disease, and find out what to do if you think...

13

62

228

@polybioRF

PolyBio

6 months

4. French National Institute for Health & Medical Research/ESPOIRS: “SARS-CoV-2 persistence and impact on LongCOVID megakaryocytes & platelets” 👉 Learn more here:

Tweet card media

SARS-CoV-2 persistence and impact on Long COVID megakaryocytes & platelets - PolyBio Research...

Project summary: The project will determine if replication-competent SARS-CoV-2 virus can be identified in the megakaryocytes (bone marrow-derived cells) and platelets...

3

40

227

@polybioRF

PolyBio

2 years

Yes. We are working directly with this team to support them in translating their PET/radioligands to image SARS-CoV-2 reservoir in #LongCovid . We are seeking private donors to support the project (which is part of a larger research program focused on SARS-CoV-2 viral persistence)

@LongCovidAdvoc

Long Covid Advocacy 💙

@LongCovidAdvoc

2 years

Could VRCPET Scans that are being used to detect HIV virus be used to detect #COVID19 in #LongCovid ? @microbeminded2 @dbkell @VirusesImmunity

0

5

39

20

74

224

@polybioRF

PolyBio

10 months

We recently held the PolyBio Fall #Symposium It featured short talks by researchers working on PolyBio-supported projects, including those collaborating via our #LongCovid Research Consortium Talk videos are now posted here:

Tweet media one

13

91

225

@polybioRF

PolyBio

2 months

11/ Drs. Peluso, Henrich and team are already running clinical trials of #monoclonals and #antivirals to target persistent COVID, but many more trials with a wider range of therapeutics are urgently needed.

6

29

227

@polybioRF

PolyBio

6 months

3. Yale University School of Medicine: “Molecular identification of SARS-CoV-2 RNA persistence” 👉 Learn more here:

Tweet card media

Molecular identification of SARS-CoV-2 RNA persistence - PolyBio Research Foundation

Project summary: The project is using a mouse model of persistent SARS-CoV-2 infection to determine mechanisms by which the virus or...

2

36

223

@polybioRF

PolyBio

8 months

We are thankful to announce a new grant from the Wallace Foundation. Funding will expand an important #LongCovid biomarker study, including extending participation to housebound & pediatric LongCovid patients. More here:

Tweet card media

PolyBio/Harvard Medical School team receive grant to expand Long COVID biomarker study - PolyBio...

(Medford MA, December 28 2023) – PolyBio Research Foundation is excited to announce a grant from the Wallace Foundation – a...

10

61

216

@polybioRF

PolyBio

3 months

Last Friday we held a Symposium where PolyBio-supported teams gave updates on their #LongCovid , #ME /CFS & tick-borne/vector-borne illness projects and clinical trials. Videos of the Symposium talks are now online here:

Tweet card media

Spring 2024 Symposium - PolyBio Research Foundation

12

98

218

@polybioRF

PolyBio

2 years

We also want to thank a Norwegian private donor who supported this project on behalf of all #Norwegian ME patients. His hope is that the study will push back against the CBT/GET proponents who largely dominate Norwegian #ME health & welfare agencies.

@microbeminded2

Amy Proal, PhD

@microbeminded2

2 years

So it turns out we did find “something in the blood” of #ME /CFS patients: fibrinaloid microclots + hyperactivated platelets (that you can see with your own eyes). Thank you so much to @polybioRF donors who helped support part of the study:

Tweet media one

Tweet media two

Tweet media three

120

900

3K

5

45

217

@polybioRF

PolyBio

2 months

7/ Viral RNA was detected in samples from all five long COVID patients. The chronic #viral RNA was discovered in connective tissue of the gut wall, a site rich in immune cells. This suggests the persistent virus may be prompting an immune response, potentially driving LC symptoms

2

35

216

@polybioRF

PolyBio

2 months

4/ More specifically, the team used an advanced #imaging method called whole-body positron emission tomography with a special tracer injected by vein to map activated T cells throughout the bodies of study participants from 27 to 910 days following #COVID infection.

1

23

215

@polybioRF

PolyBio

2 months

6/ Because the gut was a prime site of T cell activation in participants with long COVID, the scientists analyzed gut #tissue obtained from a subset of patients. In these samples, they identified the presence of #SARS -CoV-2 RNA up to 676 days following initial COVID onset.

Tweet media one

2

36

214

@polybioRF

PolyBio

1 month

7/ While this group used LPS which is the part of #bacteria that drives inflammation, the phenomenon of priming also relates to other, non-infectious inflammatory challenges such as a concussion.”

3

19

213

@polybioRF

PolyBio

2 months

10/ The next step is to rapidly scale up clinical trials capable of treating persistent virus and immune activation in long COVID.

1

26

209

@polybioRF

PolyBio

4 months

The PolyBio Symposium is just a week away! Scientists from our #LongCovid Research Consortium will give 10 min lightning talks on their research/clinical trial projects:

Tweet card media

Spring 2024 Symposium - PolyBio Research Foundation

5

88

206

@polybioRF

PolyBio

10 months

PolyBio-supported study finds SARS-CoV-2 proteins in #LongCovid blood 👉”Overall, the study findings provide additional rationale for interventions meant to reduce or eliminate #SARS -CoV-2 reservoirs or persistent protein in LongCovid patients.” More here:

9

74

199

@polybioRF

PolyBio

10 months

Proud to have supported this work via our #LongCovid Research Consortium 👉 The study “provides strong evidence that #SARS -CoV-2 should be added to the list of RNA #viruses whose components may persist beyond the period of acute illness”

@MichaelPelusoMD

Michael Peluso, MD

@MichaelPelusoMD

10 months

Recent @UCSF #LIINC preprint finding SARS-CoV-2 antigen in plasma up to 14 months post-COVID. Samples prior to vaccine/reinfection. I now believe this is happening in at least some people. Major question - does this cause #LongCovid ? To be determined.

Tweet media one

18

113

298

7

60

192

@polybioRF

PolyBio

2 months

9/ “We found #SARS -CoV-2 double-stranded RNA in 3 long COVID gut samples” says Tim Henrich MD, a Professor of Medicine in Residence at UCSF who co-led the study. “This double-stranded RNA is usually produced during viral #replication or active viral life cycling.”

Tweet media one

2

26

192

@polybioRF

PolyBio

6 months

17. Icahn School of Medicine at Mount Sinai: “LongCOVID open medical education program” 👉 Learn more here:

Tweet card media

LongCOVID open medical education program - PolyBio Research Foundation

Project summary: Development of a comprehensive education program on LongCOVID and related virus-driven chronic illness. Educational materials will be offered online free...

2

37

193

@polybioRF

PolyBio

1 year

The paper - written by 33 scientists - represents one of the largest academic collaborations in the PASC (Long COVID) space, with scientists from institutions including PolyBio Research Foundation, Harvard Medical School, and UPenn all serving as authors👇

Tweet media one

7

59

189

@polybioRF

PolyBio

3 years

2/ Among several initiatives, the project will use 7-Tesla imaging to examine relationships b/t craniocervical junction structure, #cerebrospinal fluid flow, neurovasculature + #vagus nerve activity in patients vs. controls

2

18

188

@polybioRF

PolyBio

6 months

2. University of California San Francisco: “LIINC PASC Tissue Program: A multimodal assessment of the tissue-based virologic drivers of Long COVID” 👉 Learn more here:

Tweet card media

LIINC PASC Tissue Program: A multimodal assessment of the tissue-based virologic drivers of Long...

Project Summary: The PASC Tissue Program is the first in the world to comprehensively sample multiple tissues including gut, lymph node,...

2

31

190

@polybioRF

PolyBio

6 months

5. UMass Chan Medical School: “Impact of SARS-CoV-2 infection on Alzheimer’s and neurodegenerative disease” 👉 Learn more here:

Tweet card media

Impact of SARS-CoV-2 infection on Alzheimer's and neurodegenerative disease - PolyBio Research...

Project summary: The project will determine if live SARS-CoV-2 infection of human brain cell models leads to protein formation and gene...

1

33

188

@polybioRF

PolyBio

6 months

2/ The projects/trials further address #SARS -CoV-2 persistence in #LongCOVID , plus the impact of viral activity on #Alzheimer ’s & cardiovascular disease. They include:

4

28

187

@polybioRF

PolyBio

2 years

We did it! Our fundraiser to buy @resiapretorius a flow cytometer has reached its final goal! Thank you to every person who donated, even under difficult financial circumstances. Huge thanks to Balvi ( @VitalikButerin ) for matching donations, and @givewithkernls for their support

Tweet media one

Tweet media two

4

29

186

@polybioRF

PolyBio

6 months

“The UCSF team includes people who helped make HIV and AIDS a treatable disease,” said Amy Proal, president of @polybioRF , whose research foundation is pumping $3 million into the long COVID tissue program 👇

Tweet card media

UCSF launches novel approach to help unravel mysteries of long COVID

Hoping to speed up understanding of long COVID, UCSF researchers have announced the...

www.sfchronicle.com

2

39

187

@polybioRF

PolyBio

11 months

The PolyBio Fall Symposium is this Friday! Join us for an afternoon of #infection -associated chronic disease project updates, insights, and discussion. Check out the schedule & register here:

Tweet media one

9

80

175

@polybioRF

PolyBio

11 months

The PolyBio Fall online Symposium is ready to roll Friday Oct 20 from 12:30 - 5 pm ET! Check out the speakers and talks here, plus there is a link for free registration:

Tweet media one

9

80

179

@polybioRF

PolyBio

10 months

We are glad to have supported this study via our #LongCovid Research Consortium 👇The team primarily found activation of the alternative complement pathway in LongCovid, which can be triggered by persistent #pathogens or damaged tissue such as endothelium

@EricTopol

Eric Topol

10 months

The potential for activated complement proteins to be a biomarker for #LongCovid

Tweet media one

0

71

262

2

45

180

@polybioRF

PolyBio

8 months

Great to see this paper published in Nature Immunology. We are proud to have supported the work via our #LongCovid Research Consortium👇

@MichaelPelusoMD

Michael Peluso, MD

@MichaelPelusoMD

8 months

@GladstoneInst @UCSF New #LIINC paper on immune dysfunction in #LongCovid . @UCSF + @GladstoneInst labs found SCV2-specific T cell tissue-homing and exhaustion supporting #LongCovid as a tissue-based disease with ongoing SCV2 stimulation. Supports targeting virus in trials.

Tweet media one

9

67

222

7

48

178

@polybioRF

PolyBio

2 years

2/ We are so thankful for Balvi and @VitalikButerin ’s support! Vitalik and the Balvi team are funding high-value projects on #COVID -19 and #LongCovid and we are honored that our project fell into that important category

2

13

176

@polybioRF

PolyBio

2 months

8/ Indeed some gut samples showed strong evidence of active #viral presence.

1

18

179

@polybioRF

PolyBio

6 months

A huge thank you to all our donors including @VitalikButerin for making the projects happen. Consortium teams are openly sharing ideas and samples across dozens of different academic institutions, laboratories, and clinics

6

17

178

@polybioRF

PolyBio

6 months

10. Icahn School of Medicine at Mount Sinai: “LongCOVID & ME/CFS Lumbrokinase clinical trial” 👉 Learn more here:

Tweet card media

Lumbrokinase LongCOVID & ME/CFS clinical trial - PolyBio Research Foundation

Project Summary: A clinical trial to test if the fibrinolytic enzyme Lumbrokinase improves symptoms and mitigates blood clotting issues or platelet hyperactivation...

3

30

175

@polybioRF

PolyBio

4 years

Yes! #MECFS patients are often EBV-longhaulers, CMV-longhaulers, enterovirus-longhaulers etc! So if we better study those #viruses (including their mechanisms of persistence) in ME/CFS with the same motivation + advanced tools being used w/ #COVID -19 we cld make real progress

6

48

172

@polybioRF

PolyBio

10 months

@UCSFMedicine 14/ This infrastructure can be easily replicated at other centers. "People with Long COVID have the right to access care in spaces where they feel safe and do not have to fear reinfection" says Dr. David Putrino, The Nash Family Director of the CoRE.

1

25

170

@polybioRF

PolyBio

1 year

Our #LongCovid Research Consortium & colleagues have published a paper reviewing evidence for SARS-CoV-2 reservoir (viral persistence) in Long COVID/PASC and delineating mechanisms by which a SARS-CoV-2 reservoir may contribute to disease. More here:

Tweet card media

PolyBio Consortium & colleagues publishes Nature position paper on SARS-CoV-2 reservoir in Long...

(Medford MA, September 4, 2023) – PolyBio Research Foundation is excited to announce that a position paper written by the Organization’s...

5

49

168

@polybioRF

PolyBio

6 months

6. New York University Grossman School of Medicine: “Deep characterization of SARS-CoV-2 cardiovascular reservoirs and plaque formation ” 👉 Learn more here:

Tweet card media

Deep characterization of SARS-CoV-2 cardiovascular reservoirs and plaque formation - PolyBio...

Project summary: To analyze tissue samples obtained from patients undergoing heart transplants to explore SARS-CoV-2 viral reservoirs in human vasculature (blood...

1

29

169

@polybioRF

PolyBio

4 months

PolyBio’s core team recently met with collaborators in NY & CA - visiting Mt Sinai’s CoRE clinic, the J Craig Venter Institute, and UCSF’s LIINC study team - then attended the first ever Infectious Disease Molecular Imaging conference. Read more here:

Tweet card media

PolyBio core team USA trip bolsters collaborative research program - PolyBio Research Foundation

Medford MA, April 29 2024 – Over the past month PolyBio core members Dr. Amy Proal and Dr. Mike VanElzakker traveled...

1

44

166

@polybioRF

PolyBio

2 years

3/ The project is also the first in a new collaboration we will be launching with #LongCovid patients + top global researchers & clinicians to rapidly execute a comprehensive research program on #viral persistence in LongCovid. Stay tuned for more details to come!

4

17

165

@polybioRF

PolyBio

3 years

3/ The study will take place at the Harvard/MIT Martinos Center. More info here:

Tweet media one

1

12

165

@polybioRF

PolyBio

1 year

1. Perelman School of Medicine University of Pennsylvania: “Long COVID: Using #SARS -CoV-2 specific T cells as biosensors of viral persistence” 👉 Learn more here:

Tweet card media

Long COVID: Using SARS-CoV-2 specific CD8 T cells as biosensors of viral persistence - PolyBio...

Project Summary: This project will determine if CD8 T cells specific for SARS-CoV-2 proteins can be used as blood-based biosensors of...

3

21

164

@polybioRF

PolyBio

10 months

2/ The funding will support a second phase of research and clinical trials via the #LongCovid Research Consortium (LCRC): a global scientific collaboration to rapidly and openly study core biological drivers of Long COVID:

Tweet card media

LongCovid Research Consortium (LCRC) - PolyBio Research Foundation

1

17

162

@polybioRF

PolyBio

1 year

Hi #LongCovid patients! - if you can get to Philadelphia PA for 3 separate visits, this important study of LongCovid lymph node immune responses is recruiting more participants. Email hannah.sharpe @pennmedicine .upenn.edu for more info:

Tweet media one

7

119

156

@polybioRF

PolyBio

10 months

9/ “This suggests that the neuroinflammation in #LongCovid patients may be connected to vascular problems” says Dr. VanElzakker

1

34

155

@polybioRF

PolyBio

6 months

8. University of California San Francisco: “COVID-19 Post Sudden Death Autopsy Study” 👉 Learn more here:

Tweet card media

COVID-19 Post Sudden Death Autopsy Study - PolyBio Research Foundation

Project summary: The project is expanding the one-of-a-kind POstmortemSystematic InvesTigation of Sudden Cardiac Death (POST SCD) autopsy study to examine key...

1

27

156

@polybioRF

PolyBio

10 months

3/ This is Buterin's second $15M gift to the Consortium and will allow dozens of new projects to move forward. The focus will be the continued study and treatment of #SARS -CoV-2 persistence as a driver of LongCovid.

4

12

154

@polybioRF

PolyBio

2 years

LongCovid patients: We want to let you know about a new #LongCovid research study👇To participate you must be able to make at least 3 visits to University of Pennsylvania. You will be invited to give small samples of blood, and cells from a lymph node. Contact info is here:

Tweet media one

12

88

150

@polybioRF

PolyBio

6 months

7. Karolinska Institutet Sweden: “Genetic variants and restrained antiviral immunity in severe LongCOVID” 👉 Learn more here:

Tweet card media

Genetic variants & restrained antiviral immunity in severe LongCOVID - PolyBio Research Foundation

Project Summary: To determine the underlying genetic causes and other modifying factors like sex hormones and interferon responses impacting restrained T...

1

21

152

@polybioRF

PolyBio

3 years

4/ Thank you so much to everyone who helped us raise funding and awareness of the Project! Special thanks to @cstroeckw who made a $10,000 contribution that helped jump-start the #donor -funding process

4

7

150

@polybioRF

PolyBio

10 months

2/ They additionally found that #neuroinflammation positively correlated with blood measures related to vascular dysfunction. The study is supported via our LongCovid Research Consortium

Tweet media one

1

32

149

@polybioRF

PolyBio

1 year

2. JCVI/Cardiff University/Karolinska Institutet: “Elucidation of SARS-CoV-2 reservoir and related Long COVID pathology in #lung tissue, fluid, and blood using molecular #virology & advanced sequencing” 👉 Learn more here:

Tweet card media

Elucidation of SARS-CoV-2 reservoir and related LongCovid pathology in lung tissue, fluid, and...

Project Summary: A multi-site collaborative study to identify infectious, immune and microbiome abnormalities that contribute to pulmonary symptoms in individuals with...

2

13

148

@polybioRF

PolyBio

10 months

8/ They found that seven vascular factors including fibrinogen and L-selection were significantly correlated with neuroinflammation in the #LongCovid group

1

27

146

@polybioRF

PolyBio

3 years

5/ The proejct will run in parallel with our Tissue Analysis Pipeline that will look for infectious, genetic, immune + related abnormalities in tissue samples collected from complex chronic #illness patients via surgery and/or biopsy, including from patients w/ structural issues

6

10

146

@polybioRF

PolyBio

6 months

11. University of Pennsylvania: “LongCOVID: Defining the viral RNA reservoir in the gastrointestinal tract” 👉 Learn more here:

Tweet card media

Long COVID: Defining the viral RNA reservoir in the gastrointestinal tract - PolyBio Research...

Project Summary: This project combines experiments in humans, non-human primates, and mice to determine mechanisms by which SARS-CoV-2 reservoir in the...

1

26

147

@polybioRF

PolyBio

6 months

Mount Sinai Receives $2.6 Million Grant From PolyBio Research Foundation for Long COVID Clinical Trials 👇

Tweet card media

Mount Sinai Receives $2.6 Million Grant From PolyBio Research Foundation for Long COVID Clinical...

www.mountsinai.org

5

32

147

@polybioRF

PolyBio

6 months

We are glad to be one of the funders to support this new preprint 👇 A better understanding of sex/hormonal differences in #LongCovid can help improve individualized patient care

@VirusesImmunity

Prof. Akiko Iwasaki

@VirusesImmunity

6 months

So what is driving the male LC immune signatures? Testosterone! Regardless of sex, those with higher testosterone levels had higher male LC immune signatures. Those with lower testosterone had higher female LC immune signatures. (12/)

Tweet media one

3

90

549

3

32

144

@polybioRF

PolyBio

1 year

And there are more projects in development! Huge thanks to @VitalikButerin + other PolyBio donors for project support. Some LCRC teams are already analyzing #ME /CFS or #LongLyme samples…but our long-term goal is to iterate as many other projects as possible into those diagnoses

9

2

144

@polybioRF

PolyBio

4 months

The study found vestiges of SARS-CoV-2 in blood and multiple organs — including the liver, stomach, and brain — for up to four months after infection…patients were over five times more likely to report long Covid symptoms if they were persistently harboring viral material 👇

@bhanlon15

Billy Hanlon

4 months

Bloomberg: 'Unraveling The Stubbornly Persistent Covid-Gut Nexus' 'Everyone must know at least one person with long Covid, given its prevalence. While scientists haven’t figured out the causes, some likely explanations are coming into focus.'

3

15

65

3

54

144

@polybioRF

PolyBio

2 years

Thank you very much @Tempi_Stiftung @cstroeckw for supporting us via the first-ever “Johadamis ME/CFS Research Grant.” 🙌 We are very excited to work with @VirusesImmunity to identify signs of infection in #ME /CFS blood + cerebrospinal fluid, in concert with @BjornBragee

@weandmecfs

WE&ME Foundation

2 years

🚨We are happy to announce the recipient of the 2022 "Johadamis #MECFS Research Grant." Prof. Akiko Iwasaki @VirusesImmunity , in collaboration with @polybioRF , will screen blood + cerebrospinal fluid of a well-defined Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort.

Tweet media one

39

145

498

3

26

141

@polybioRF

PolyBio

6 months

12. The J. Craig Venter Institute: “LongCOVID oral cavity biomarker study” 👉 Learn more here:

Tweet card media

Long COVID oral cavity biomarker study - PolyBio Research Foundation

Project summary: To determine the degree to which the oral cavity can serve as a window into the identification LongCOVID immune,...

2

19

143

@polybioRF

PolyBio

8 months

We are supporting John Wherry and team via our #LongCovid Research Consortium. They are working to determine if CD8T cells specific for #SARS -CoV-2 proteins can be used as blood-based biosensors of SARS-CoV-2 persistence. Learn more here:

Tweet card media

Long COVID: Using SARS-CoV-2 specific CD8 T cells as biosensors of viral persistence - PolyBio...

Project Summary: This project will determine if CD8 T cells specific for SARS-CoV-2 proteins can be used as blood-based biosensors of...

@loscharlos

charlos

8 months

@UCSF “Its findings support growing evidence about the underlying contributors to #LongCovid in some individuals — including that pieces of the coronavirus never cleared from their body,” said John Wherry of the University of Pennsylvania,

1

9

54

3

44

141

@polybioRF

PolyBio

10 months

13/ The team is also running a similar PET imaging study in patients with #ME /CFS, so that comparison of neuroinflammation and vascular factors between patients with the two related diagnoses can be compared

3

18

143