Bacteria and archaea have innate immune receptors that recognize conserved viral proteins and prevent infection.

Nature - After taking up tumour-associated antigens, dendritic cells in mouse and human tumours upregulate a regulatory gene program that limits dendritic cell immunostimulatory function, and...

A handful of immunologists are pushing the field to take attributes such as sex chromosomes, sex hormones, and reproductive tissues into account.

Nature Medicine - Being a parent scientist can feel like a catch-22, feeling guilty for both the time spent away from the children and the time spent away from the bench. Embracing healthy...

Nature Reviews Immunology - This Comment article from the Precision Immunology Institute at the Icahn School of Medicine (PrIISM), New York, describes their efforts to provide critical reviews of...

This study was a single-arm, open label clinical trial with 600 mg hydroxychloroquine (HCQ) in the treatment arm (n = 20). Patients who refused participation or patients from another center not...

Large-scale immune monitoring experiments (such as clinical trials) are a promising direction for biomarker discovery and responder stratification in immunotherapy. Mass cytometry is one of the tools...

The Mount Sinai oncologist studies innate immune cells with the goal of designing novel immunotherapies, including cancer vaccines.

Cryo-EM structural analysis of a T cell receptor (TCR) complex bound to a tumor-specific human class I pMHC indicates the functional impact of connecting peptides and sterol lipid for complex...

Researchers at the Icahn School of Medicine at Mount Sinai have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of non-small cell lung cancer (NSCLC).

The aim of this study was to identify diagnostic or prognostic criteria which could identify patients with COVID-19 and predict patients who would go on to develop severe respiratory disease. The...

Multidisciplinary research center to define, map, and understand the health consequences of interactions between the nervous system and the immune system 

The rising cancer treatment and technology known as CAR-T uses a patient's own blood cells to cure their malignancies.

This notebook collects the latest COVID-19 preprints available from bioRxiv/medRxiv and the latest reviews from https://github.com/ismms-himc/covid-19_sinai_reviews. Click on a title to view the...

Nature Immunology - Heeger and colleagues report that activated B cells dynamically regulate the expression of complement regulatory proteins via the transcription factor BCL6. C3 convertase...

He et al. find that food colorants Red 40 and Yellow 6 induce colitis in mice with dysregulated expression of IL-23. Colitis development requires bacterial processing of the food colorants and is...

Protein-level genetic barcodes enable single-cell high-dimensional phenotyping by mass cytometry in CRISPR screens.

Nature Immunology - Brown and colleagues generated an atlas of miRNA expression profiles from primary mouse immune cell populations and connected these signatures with ATAC–seq,...

Main findings The authors performed single-cell RNA sequencing (scRNAseq) on bronchoalveolar lavage fluid (BAL) from 6 COVID-19 patients (n=3 mild cases, n=3 severe cases). Data was compared to...

Autoinflammatory disease can result from monogenic errors of immunity. We describe herein the first example of a patient with early-onset widespread autoinflammation resulting from a mosaic, hetero...