Dr. Drew Weissman calls his parents just after learning he's won the 2023 Nobel Prize in Physiology or Medicine. Dr. Weissman and Dr. Katalin Karikó received...

The Nobel Prize in Physiology or Medicine 2023 was awarded jointly to Katalin Karikó and Drew Weissman "for their discoveries concerning nucleoside base modifications that enabled the development of...

DNA and RNA stimulate the mammalian innate immune system through activation of Toll-like receptors (TLRs). DNA containing methylated CpG motifs, however, is not stimulatory. Selected nucleosides in...

The mRNA technology at the heart of two Covid-19 shots has been decades in the making. Now it may soon be used to fight cancer and HIV. (Video by Vicky Feng) (Source: Bloomberg)

Targeting specific messenger RNA–encapsulating lipid nanoparticles to hematopoietic stem cells permits in vivo bone marrow transplantation.

In vivo generation of CAR T cells by delivery of modified mRNA improves recovery in a mouse model of heart failure.

An experimental mRNA vaccine provides protection in preclinical animal models against infection from Borrelia burgdorferi, the bacteria that causes Lyme disease. Results suggest that the vaccine...

Communications Biology - The role of empty lipid nanoparticles in eliciting dendritic cell maturation and innate immune signaling is shown to be impaired in older adults, potentially contributing...

Vaccines are just the beginning of the potential for messenger RNA, the Nobel Prize-winning technology.

mRNA vaccines expressing antigens from all known influenza subtypes elicit protective responses in mice and ferrets.

mRNA vaccines are highly effective against COVID-19. Mu et al. demonstrate the use of mRNA to express HIV-1 Env trimers scaffolded on ferritin nanoparticles. mRNA vaccination in mice induced autolo...

2022 Warren Alpert Prize Honors mRNA Research that Enabled the Design of COVID-19 Vaccines

A look at the features for this week's broadcast of the 2023 News & Documentary Emmy-winner for Outstanding Recorded News Program, hosted by Jane Pauley.

Although the production time (11 months) of the messenger RNA vaccines against SARS-CoV-2 infection set a record, the preclinical research undergirding them spanned decades and was challenged by la...

Instructing our cells to make specific proteins could control influenza, autoimmune diseases, even cancer

Katalin Karikó and Drew Weissman have won more than a dozen honors for their research.

The National Academy of Medicine (NAM) today announced the election of 90 regular members and 10 international members during its annual meeting. Election to the Academy is considered one of […]

Therapeutic mRNA has the potential to revolutionize the treatment of myriad diseases and, in 2020, facilitated the most rapid vaccine development in history. Among the substantial advances in mRNA...

Delivery of nucleic acids with viral and synthetic vectors has pioneered genetic nanomedicine. Four-component lipid nanoparticles (LNPs) consisting of ionizable lipids, phospholipids, cholesterol,...

Three Penn faculty members have been named National Academy of Inventors (NAI) Fellows. Katalin Karikó and Drew Weissman of the Perelman School of Medicine and Dean Vijay Kumar of the School of...

Columbia will award the 2021 Louisa Gross Horwitz Prize to Katalin Karikó, PhD, and Drew Weissman, MD, PhD, for trailblazing work on messenger RNA (mRNA) vac...

University of Pennsylvania scientists Katalin Karikó and Drew Weissman to be honored at June 7 symposium for their research that enabled Covid-19 vaccines.

On September 14, Wexford Science & Technology, LLC and the University of Pennsylvania announced that the University has signed a lease for new laboratory space … Read More ›

An international award founded in Vietnam to honor scientific achievements gave out $4.5 million worth of prizes to several global scientists Thursday night.

To date, the most outstanding product of the awardees’ work has been “the timely and prompt development of SARS-CoV-2 vaccines,” which have proved to “effectively provide protection against severe...

Three doctors from Canada, Hungary and United States have been honoured with the Prince Mahidol Award for their work on Covid-19 mRNA vaccines.

U.S.-based winners of three 2023 Nobel Prizes were honored at a symposium hosted by the National Academy of Sciences and the Embassy of Sweden. The event provided laureates with an opportunity to...

Lipid nanoparticles deliver mRNA to insulin-producing cells in the pancreas.

Watch this Scientific Journal Video about Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing at JoVE.com

Gov. Josh Shapiro, President Liz Magill, and others from the University community celebrated the new home of the Penn Institute for RNA Innovation.

The University of Pennsylvania School of Veterinary Medicine today announced the mRNA Research Initiative to advance veterinary vaccine science.

Join the Embassy of Sweden and the National Academy of Sciences for the 2023 Nobel Prize Symposium from House of Sweden, Washington, DC. The event is a uniqu...

Since the success of the COVID-19 vaccine, RNA therapies have been the object of increasing interest in the biotech world. These therapies work with your … Read More ›

Messenger RNA went from "a technology looking for a disease" to a global phenomenon in what seems like an instant thanks to the COVID-19 vaccines. | Thanks to the success of Moderna and BioNTech’s...

DURHAM, N.C. – Using mRNA technology like that in the COVID-19 vaccines, researchers have demonstrated a successful way to deliver a potential HIV vaccine, researchers at Duke Human Vaccine Institute...

More than one million people died just in the U.S. as a result of the COVID-19 pandemic that broke out in 2020. But a scientific miracle – a vaccine released later that same year – saved countless...

On the day of their win, the Penn Medicine community celebrated the two mRNA technology pioneers on their 2023 Nobel Prize recognition and found inspiration for the future of world-changing science...

By decorating lipid nanoparticles with a cell-specific surface marker, researchers from the University of Pennsylvania were able to edit haematopoietic stem cells in vivo, offering a key alternative...

Prince Mahidol Award Laureates 2021 in the Field of MedicineArmchair Interview: Development of the mRNA Vaccine and Future Applications

Researchers getting closer to a “universal” flu vaccine

Researchers at Penn Medicine and the Children’s Hospital of Philadelphia discovered a new way to deliver mRNA to blood stem cells in bone marrow. The result could be simpler treatments for infectious...

A new mRNA vaccine that targets all known flu strains is showing promise in early animal trials, opening the door to the possibility of a universal shot that...

Nature Communications - The public health concern caused by influenza B virus is often overlooked, yet represents a significant global burden. Here, the authors evaluate the cellular and humoral...