Pagliarini Lab @Pagliarini_Lab Twitter profile

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Pagliarini Lab

@Pagliarini_Lab

2 years

I am very pleased to share our new 'MITOMICS' work exploring mitochondrial protein function and pathogenesis published today in @Nature . A great collaborative effort with @Coon_Labs , and the groups of Rob Taylor, Nurten Akarsu, and Mark Craven.

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Pagliarini Lab

@Pagliarini_Lab

2 months

@HHMINEWS I’m honored and humbled to be joining this inspiring cohort of new HHMI Investigators, and extremely grateful for the talented scientists I’ve had the privilege of working with in my lab these past 15 years. This is really a reflection of their efforts and ingenuity! @HHMINews

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Pagliarini Lab

@Pagliarini_Lab

1 year

Happy to share our new mitochondrial proteome research review out today in @NatRevMCB led by @Zak_Bakes and @PatrickForny . The field has come a long way in the past 20 years, yet plenty of exciting new things to do! #Mitochondria

Mitochondrial proteome research: the road ahead

Nature Reviews Molecular Cell Biology - The mitochondrial proteome is highly complex, comprising ~1,000–1,500 proteins in mammals. Recent technological advances are now helping to refine the...

www.nature.com

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Pagliarini Lab

@Pagliarini_Lab

1 year

Excited to share our new discovery of a mitochondrial isoprene transporter published today in @NatureCellBio and led by @mitojondrion ! Interesting example of transporter dual functionality. #Mitochondria

Hem25p is required for mitochondrial IPP transport in fungi

Nature Cell Biology - Tai et al. show that Hem25p—a mitochondrial glycine transporter required for haem biosynthesis—is also needed for isopentenyl pyrophosphate (IPP) transport into...

www.nature.com

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Pagliarini Lab

@Pagliarini_Lab

5 years

After 10+ fantastic years in Madison, it is bittersweet to announce that my lab and I are moving to @WUSTLmed soon. I am so grateful to everyone at @UWBiochem and @Morgridge_Inst for their support and guidance. Stay healthy, and come visit us in St. Louis!

Pagliarini named BJC investigator | Washington University School of Medicine in St. Louis

Metabolism expert known for work on the powerhouses of the cell

medicine.wustl.edu

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Pagliarini Lab

@Pagliarini_Lab

2 years

Equally excited to share our new @nchembio paper describing a mitochondria-specific repurposed kinase inhibitor to manipulate CoQ biosynthesis. Congrats to lead author @nhmurray12 , Chris Asquith, and all our collaborators!

Small-molecule inhibition of the archetypal UbiB protein COQ8

Nature Chemical Biology - Murray et al. identified and characterized a small-molecule inhibitor of human COQ8A, which belongs to the UbiB protein family and is essential for coenzyme Q biosynthesis.

www.nature.com

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Pagliarini Lab

@Pagliarini_Lab

2 months

Many thanks for all the very kind messages! My team and I are excited by all the ways this will empower our science, hopefully in collaboration with many of you.

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Pagliarini Lab

@Pagliarini_Lab

1 year

I’m pleased to share our new work on the mitochondrial phosphatase PPTC7 led by @nieminm ! Check out the important roles this protein plays in mitophagy and metabolic regulation. #mitochondria

PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

Nature Communications - The mitochondrial phosphatase PPTC7 has previously been linked to the maintenance of mitochondrial content, but the mechanisms underlying this phenotype remain unclear....

www.nature.com

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Pagliarini Lab

@Pagliarini_Lab

1 year

CoQ10 is large and very hydrophobic, which limits its bioavailability. Our new study, led by @LauraSteenberge , shows that CoQ4 is a sufficient substitute for multiple CoQ functions in cells and can be targeted to mitochondria. #bioRxiv #mitochondria #CoQ

Coenzyme Q4 is a functional substitute for coenzyme Q10 and can be targeted to the mitochondria

Coenzyme Q10 (CoQ10) is an important cofactor and antioxidant for numerous cellular processes, and its deficiency has been linked to human disorders including mitochondrial disease, heart failure,...

www.biorxiv.org

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Pagliarini Lab

@Pagliarini_Lab

4 years

We are very excited to be up and running at @WUSTLmed ! I don't advise trying to move your life and lab during a pandemic. Check out our new website for more info: #Mitochondria

Pagliarini Lab

An interdisciplinary biomedical research laboratory driven to elucidate and address the biochemical underpinnings of mitochondrial dysfunction in human disease.

pagliarinilab.org

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Pagliarini Lab

@Pagliarini_Lab

5 months

CoQ10 is a very hydrophobic molecule with poor bioavailability. In this new study, led by @LauraSteenberge , we build on prior work to show that the much more soluble CoQ4 is sufficient to rescue diverse CoQ functions and can be targeted to mitochondria.

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Pagliarini Lab

@Pagliarini_Lab

2 years

I am happy to share (a bit late) our new review on coenzyme Q biology published recently in @TrendsBiochem . Congratulations to Dr. Rachel Guerra for leading the charge! Coenzyme Q biochemistry and biosynthesis

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Pagliarini Lab

@Pagliarini_Lab

2 years

Very excited to share our new @MolecularCell paper describing the structure and functionality of a CoQ-related complex. Wonderful collaboration with Adam Frost, @matteodp , @Aydinlab , and others. Mateusz Manicki was indefatigable in driving this one home!

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Pagliarini Lab

@Pagliarini_Lab

3 years

Mitochondriacs: @drbentu , @aliceyting , and I are excited to see you at the Keystone meeting on Mitochondrial Biochemistry in Health and Disease next March 27-30 in Breckenridge. Check the link for key deadlines, including the Dec. 9 abstract deadline!

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Pagliarini Lab

@Pagliarini_Lab

5 months

Mitochondrial complex I construction relies on a patchwork of poorly defined "assembly factors." In work led by @andrew_sung , we used deep mutational scanning to elucidate NDUFAF6 function and predict variant pathogenicity. @taylorlabncl @melogrammatical

Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease

Nature Metabolism - Sung et al. provide a powerful pipeline based on deep mutational scanning to elucidate the molecular mechanisms of mitochondrial complex I assembly and predict pathogenicity of...

www.nature.com

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Pagliarini Lab

@Pagliarini_Lab

5 years

I am quite honored to receive this award named after two scientists we should all strive to emulate. Many thanks to @ASBMB , all of our supporters at @Morgridge_Inst and @UWBiochem , and of course to the amazing scientists in our lab. Looking forward to @expbio in April!

ASBMB

@ASBMB

5 years

David Pagliarini ( @Pagliarini_Lab ) of @UWMadison is the 2020 winner of our Earl and Thressa Stadtman Young Scholar Award. 👏👏👏 You're going to want to put his award lecture on your @expbio itinerary. Here are the rest of our 2020 winners:

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Pagliarini Lab

@Pagliarini_Lab

3 years

Very excited to share our new preprint on the "Structure and functionality of a multimeric human COQ7:COQ9 complex." Great collaboration with Adam Frost, @Aydinlab , @labriataphd , @matteodp and @Coon_Labs . #mitochondria #CoQ

Structure and functionality of a multimeric human COQ7:COQ9 complex

Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid essential for core metabolic pathways and antioxidant defense. CoQ is synthesized upon the mitochondrial inner membrane by an ill-defined ‘complex...

www.biorxiv.org

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Pagliarini Lab

@Pagliarini_Lab

2 years

Thank you, Ben! It was quite an honor and very memorable afternoon/evening. I am extremely grateful to @WashUChancellor , @DavePistonWUSTL , Dean Perlmutter, and all others at @WUSTL and @WUSTLmed that made it happen. What an amazing university!

Ben Garcia

@GarciaLabMS

2 years

Congrats to Dave Pagliarini for being named the Hugo F. and Ina C. Urbauer Endowed Professor at @WUSTLmed . Well done! @WashUChancellor @Pagliarini_Lab @DavePistonWUSTL

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Pagliarini Lab

@Pagliarini_Lab

3 years

Mito fans: Join us in March at the @KeystoneSymp on #Mitochondrial Biochemistry! Collaborate in Breckenridge with #mitochondria experts on mechanisms, dynamics, signaling and more, or connect via virtual access #KSMitochondria22

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Pagliarini Lab

@Pagliarini_Lab

5 years

Congrats to @Morgridge_Inst Metabolism Investigator/ @UWMadison Prof Jing Fan and her lab on this great new @NatMetabolism paper! Jing is a true rising star in the field.

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Pagliarini Lab

@Pagliarini_Lab

4 years

Excited to share this story on how two poorly characterized proteins help CoQ move out of mitochondria. Congrats to leads @Zack_Kemmerer (defending next week!) and Kyle Robinson. UbiB proteins regulate cellular CoQ distribution

UbiB proteins regulate cellular CoQ distribution

Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid essential for many core metabolic processes in mitochondria, including oxidative phosphorylation[1][1]-[3][2]. While lesser appreciated, CoQ also...

www.biorxiv.org

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Pagliarini Lab

@Pagliarini_Lab

3 years

I am excited to post our new manuscript on CoQ pathway manipulation, led by @nhmurray12 . Congrats to Nate and our multiple collaborators key collaborators! Small Molecule Modulation of the Archetypal UbiB protein COQ8

Small Molecule Modulation of the Archetypal UbiB protein COQ8

Small molecule tools have enabled mechanistic investigations and therapeutic targeting of the protein kinase-like (PKL) superfamily. However, such tools are still lacking for many PKL members,...

www.biorxiv.org

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Pagliarini Lab

@Pagliarini_Lab

5 years

Quite honored to have @SenatorBaldwin visit our lab today! Senator Baldwin's grandfather, Dr. David E. Green, was a pioneer in mitochondrial biology. His lab's work at UW-Madison, especially on coenzyme Q, set the foundation for much of what we do today.

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Pagliarini Lab

@Pagliarini_Lab

3 years

Very appreciative of this opportunity and thankful to my nominators and the amazing group of scientists I've had the privilege of working with. I certainly hope to emulate the incredible Stadtmans, both in their science and their mentorship! #ASBMB2021

ASBMB

@ASBMB

3 years

Catch David Pagliarini's ( @Pagliarini_Lab ) Stadtman Young Scholar Award lecture, "Wiring the powerhouse: Systems-to-structure approaches for defining mitochondrial protein function" at 11 a.m. EDT: . Learn more about his work: .

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Pagliarini Lab

@Pagliarini_Lab

6 years

Join us in Madison this September 16-18 for our second Frontiers in Metabolism meeting at the @Morgridge_Inst . Another amazing lineup of speakers! Register now open:

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Pagliarini Lab

@Pagliarini_Lab

2 years

Mitochondria need isoprenoids from the mevalonate pathway to make CoQ, but how do they access them from the cytosol? Check out our surprising finding that Hem25p doubles as an IPP transporter. #mitochondria #CoQ Hem25p is a mitochondrial IPP transporter

Hem25p is a mitochondrial IPP transporter

Coenzyme Q (CoQ, ubiquinone) is an essential cellular cofactor comprised of a redox-active quinone head group and a long hydrophobic polyisoprene tail. How mitochondria access cytosolic isoprenoids...

www.biorxiv.org

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Pagliarini Lab

@Pagliarini_Lab

2 years

We are hiring a great new staff mass spectrometrist to help run our in-house proteomics and metabolomics platforms. Lots of great collaborative biological and methods development projects await. Please retweet! #massspectrometry #proteomics #metabolomics

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Pagliarini Lab

@Pagliarini_Lab

4 years

Happy to share this @Cell_Metabolism review from our group. @andrew_sung , @brendan_floyd , and I hope it has some useful lessons of how large-scale analyses can lead to focused mechanistic hypotheses and help functionalize orphan proteins. #mitochondria

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Pagliarini Lab

@Pagliarini_Lab

4 years

Exciting new opportunity to become the Founding Director of the new @WUSTLmed Mass Spectrometry Center. Part of a significant campus-wide investment in mass spec infrastructure and associated with the outstanding @GenomeInstitute .

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Pagliarini Lab

@Pagliarini_Lab

3 years

Excited to share our latest CoQ work, let by @Zack_Kemmerer and Kyle Robinson, out in @NatureComms today! Another collaboration with the @Coon_Labs . @WUSTLdbbs @WUSTLmed @Morgridge_Inst

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Pagliarini Lab

@Pagliarini_Lab

6 years

Excited to have worked with @jodi_nunnari and @kssubramanian12 on this @JCellBiol paper. Coenzyme Q proteins form a very interesting, dynamic complex on the mitochondrial inner membrane near ER contact sites.

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Pagliarini Lab

@Pagliarini_Lab

11 months

Rachel Guerra and I were happy to write this @nchembio News & Views highlighting the recent work by Park, Rhee et al. on RTN4IP1/OPA10 as an oxidoreductase for coenzyme Q synthesis!

Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis

Nature Chemical Biology - The development of a transgenic mouse line that expresses mitochondrial matrix-targeted APEX2 combined with proteome analysis identified RTN4IP1, which serves as an...

www.nature.com

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Pagliarini Lab

@Pagliarini_Lab

2 years

I am happy to share our new @jbiolchem work led by the newly-minted Dr. Jonathan Schmitz. Great collaboration with the @HittingerLab . Aim18p and Aim46p are chalcone isomerase (CHI)-domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae

Aim18p and Aim46p are chalcone isomerase domain–containing mitochondrial hemoproteins in Saccharo...

Chalcone isomerases (CHIs) have well-established roles in the biosynthesis of plant flavonoid metabolites. Saccharomyces cerevisiae possesses two predicted CHI-like proteins, Aim18p (encoded by...

www.jbc.org

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Pagliarini Lab

@Pagliarini_Lab

3 years

Very proud of graduate student Kyle Robinson for leading this difficult study now out @JBC . Lots left to do, but this offers some important new clues about how #CoQ is made. Thanks to @Coon_Labs for another great collaboration! #mitochondria #ASBMB

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Pagliarini Lab

@Pagliarini_Lab

3 years

A big congratulations to Kyle Robinson, who successfully defended his thesis today! That makes 12 new PhDs from our lab in as many years. Well done, Dr. Robinson!

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Pagliarini Lab

@Pagliarini_Lab

5 years

Excited that our work, led by @nieminm , is out. This phosphatase is key for mitochondrial function and there is a lot left to learn. Those interested in knowing more should make Natalie your next faculty hire — she is fantastic and on the market!

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Pagliarini Lab

@Pagliarini_Lab

4 years

Very excited to “return” to Cologne for this seminar. What an incredible mitochondrial community!

CRC_1218

@CRC_1218

4 years

🗓️Fix the date! 10.03.21 | 4pm ! Our next #virtual #mitoclub #seminar will be given by David Pagliarini ( @Pagliarini_Lab ) from @WUSTLmed St.Louis, MO>>>To get more information about our #mitoclub series>>>

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Pagliarini Lab

@Pagliarini_Lab

6 years

COQ9 repurposed an ancient bacterial fold to help surmount the hydrophobic barriers of CoQ biosynthesis. Excited to have this work—led by two outstanding graduate students—now in print in @MolecularCell .

Taking new approaches to study lipid biology - Morgridge Institute for Research

Any budding scientist knows that oil and water don’t mix. However, for our largely water-filled cells to thrive, nature needs to devise clever ways to make and move around the lipids—fat and oil-like...

morgridge.org

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Pagliarini Lab

@Pagliarini_Lab

4 years

We could not be prouder of our very own @nieminm ! @WUSTLmed landed a great one.

Natalie Niemi

@nieminm

4 years

A bit of good news in these strange times: I’m thrilled to announce that I’ll be starting my lab in the department of Biochemistry and Molecular Biophysics @WUSTL this summer. 1/n

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Pagliarini Lab

@Pagliarini_Lab

5 years

Join us for another @Morgridge_Inst Frontiers in Metabolism meeting in September! @AndersonRozalyn @Auwerx_Lab @BrunetLab @hchristofk @RJDLab @RussDeBo @ghotamis @KatjaLamia @mitodynamics @RalserLab @ElenaRugarli @DMSabatini @TobiWalther @EileenWhitePhD

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Pagliarini Lab

@Pagliarini_Lab

2 years

Congrats to Jon Schmitz on leading this study on two surprising new mitochondrial hemoproteins. Great collaboration with @hittingerlab and others! Aim18p and Aim46p are CHI-domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae

Aim18p and Aim46p are CHI-domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae

Chalcone isomerases (CHIs) have well-established roles in the biosynthesis of plant flavonoid metabolites. Saccharomyces cerevisiae possesses two predicted CHI-like proteins, Aim18p (encoded by...

www.biorxiv.org

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Pagliarini Lab

@Pagliarini_Lab

3 years

Very proud of our very own @EdreesRashan for being inducted into the Edward A. Bouchet Graduate Honor Society. Congrats, Eddie! #bouchetscholars

News

College of Agricultural and Life Sciences

biochem.wisc.edu

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Pagliarini Lab

@Pagliarini_Lab

2 years

Working with @curiousdrgeorge as our @Nature editor was such a satisfying experience. @sshadan and @Vesna_Tod along the way, too. Great editors make such a difference in the often grueling publication process!

George Caputa

@curiousdrgeorge

2 years

Congrats to @Pagliarini_Lab @Coon_Labs @Rensvold & Evgenia Shishkova on their publication in @Nature using multiomics to explore mitochondrial protein function & pathogenesis. An incredible resource OA:

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Pagliarini Lab

@Pagliarini_Lab

4 years

Mourning the loss of @UWBiochem Professor Emeritus John Suttie. John was a pioneer in vitamin K research, a @theNASciences member, and my next-door neighbor during my time in Madison. Great scientist and person.

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Pagliarini Lab

@Pagliarini_Lab

2 years

Extremely grateful for the opportunity to participate in the fantastic @aussiemit 2022 conference in Sydney! A great balance of basic and translational science. Thanks to @khoehn182 , @AusMito , and the rest of the organizers, speakers, and sponsors. #mitochondria

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Pagliarini Lab

@Pagliarini_Lab

5 years

Proud and excited that these two great lab alumni and recent @UWMadison graduates are heading off to top graduate programs. Sheila Johnson to @HarvardCCB , and Lainy Von Bank to @CMB_UWMadison . If you’re a PI in those programs, you’ll want to recruit them!

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Pagliarini Lab

@Pagliarini_Lab

2 years

I am excited to share this latest work and even more excited to see where @nieminm and her lab take this next!

Natalie Niemi

@nieminm

2 years

Excited to share our new work on the mitochondrial phosphatase Pptc7 and its role in suppressing receptor-mediated mitophagy! A 🧵1/n

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Pagliarini Lab

@Pagliarini_Lab

28 days

Great as always to work with @taylorlabncl and @MitoMonika ! Another interesting example of coordinated coenzyme Q biosynthesis and complex I assembly.

Taylor Lab

@taylorlabncl

28 days

Excited to share our latest preprint, led by @MitoMonika Rachel Guerra & @mitocollier in collaboration with the Wittig lab & @Pagliarini_Lab

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Pagliarini Lab

@Pagliarini_Lab

5 years

This is a fantastic paper. Very excited that lead author Caroline Fecher will be joining us in Madison soon!

Nature Metabolism

@NatMetabolism

5 years

@NatureNeuro 𝗧𝗵𝗼𝗺𝗮𝘀 𝗠𝗶𝘀𝗴𝗲𝗹𝗱 lab has developed an approach to isolate cell-type-specific #mitochondria from mouse #CNS and demonstrate the proteomic diversity of cerebellar mitochondria. @TU_Muenchen #NatMetabPicks

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Pagliarini Lab

@Pagliarini_Lab

6 years

And coenzyme Q was discovered in his lab at Enzyme Institute in Madison, WI in the late 1950s by Fred Crane and Bob Lester!

DeBerardinis Lab

@RJDLab

6 years

#tbt today is David Ezra Green! Green worked out the reduction potentials of #cysteine #glutathione & glycylcysteine during his PhD. There was a lot of debate about these #redox potentials which had important implications for their role in biology. Paper!

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Pagliarini Lab

@Pagliarini_Lab

2 years

I had my shoes shined (badly needed) at the Minneapolis airport today by a 94-year-old legend of a WWII vet named Paul. I asked him if he had any dietary secrets. “Nah, I eat EVERYTHING.” And also does karate and “teaches dancing.” Humbling. #metabolism

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Pagliarini Lab

@Pagliarini_Lab

4 months

Likewise thrilled to be teaming up with @bradylabupenn and the @ASBMB team to put together this program. So many great theme leaders and speakers already lined up. Join us in Chicago!

Donita Brady of Brady Lab UPenn

@bradylabupenn

4 months

Super excited to join @Pagliarini_Lab as co-chair of @ASBMB #DiscoverBMB2025 in Chicago! Learn more about the scientific program we’re planning! We hope to see you there!

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Pagliarini Lab

@Pagliarini_Lab

6 years

Have trainees who would like to learn mass spectrometry? Join us in Madison July 21-24 for our second annual North American Mass Spectrometry Summer School.

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Pagliarini Lab

@Pagliarini_Lab

5 years

Very proud of lab alumna Danielle Lohman, an amazing biochemist now applying her skills to US science policy. Check out this @cenmag article about Danielle and other recent PhDs now engaged in #scipol .

Lessons learned from a year in Washington

A half-dozen PhDs jumped from science into a fellowship to find out how the US government works. What they learned can help guide scientists nationwide

cen.acs.org

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Pagliarini Lab

@Pagliarini_Lab

4 years

Great work, Sheila! We’re proud to have you as a lab alum!

Marcia Haigis

@HaigisLab

4 years

Congrats to our grad student Sheila for passing her PQE! 🥳

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Pagliarini Lab

@Pagliarini_Lab

5 years

We're looking for a great protein biochemist to join our team as a staff scientist. Please encourage any great candidates to check out the ad below. @Morgridge_Inst is a fantastic place to work!

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Pagliarini Lab

@Pagliarini_Lab

3 years

Really enjoyed hosting @Frutag33 today for a very interesting @WUSTLmed Cell Biology & Physiology seminar today! Impressive blend of chem bio and evolutionary bio skills from her time with @kevansf and @Choano_Lab . On the job market next cycle!

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Pagliarini Lab

@Pagliarini_Lab

3 years

Fantastic postdoctoral fellowship opportunity with @warscheidlab , with an emphasis on mitochondrial stress signaling. Bettina and many others in Freiburg continue to produce inspiring, top quality mitochondrial work!

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Pagliarini Lab

@Pagliarini_Lab

3 years

Very excited that @clair569 will be joining @WUSTLmed this September as an Assistant Professor in Cell Biology & Physiology. Welcome, Clair! Another reason to celebrate today. Looking forward to some great #mitochondria collaborations.

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Pagliarini Lab

@Pagliarini_Lab

1 year

I think it’s really funny that my X account thinks Oleh keeps posting “sensitive content.” What kind of racy mitochondrial content am I missing?!

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Pagliarini Lab

@Pagliarini_Lab

5 years

I am excited to be organizing this meeting with @aliceyting and @drbentu . Join us!

UW–Madison Biochem

@UWBiochem

5 years

Our own @Pagliarini_Lab @Morgridge_Inst helping a great of scientists co-chair this Keystone meeting — apply today!

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Pagliarini Lab

@Pagliarini_Lab

2 years

Our lab is now accepting applications for a new Instructor (faculty-level) mass spectrometrist position. @mitojobs

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Pagliarini Lab

@Pagliarini_Lab

2 years

We are hoping to add 1-2 great new experimental and/or computational staff scientists to our team. See first ad below!

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Pagliarini Lab

@Pagliarini_Lab

3 years

Happy to work with @nieminm to share our thoughts on mitochondrial phosphorylation in this @jbiolchem review. Lots more to explore!

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Pagliarini Lab

@Pagliarini_Lab

5 years

I echo this sentiment and congratulations. This was a special event. The whole experience (for me in 2016, last of the Obama administration) was very uplifting and left us with a sense of optimism about the future of science in our country. Congrats and enjoy!

Harmit S. Malik

@HarmitMalik

5 years

Congrats to PECASE awardees! It was a career highlight for me; my Dad flew in from India for this in 2010 If folks think this President has anything to do with PECASE selection or is likely to show up at ceremonies. they're deluded. So, don't be a killjoy!

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Pagliarini Lab

@Pagliarini_Lab

2 years

Looking forward to your defense next week, Eddie! And can't wait to share your stellar thesis work with the world soon.

Eddie Rashan

@EdreesRashan

2 years

I feel incredibly fortunate to have had the opportunity to train under @Pagliarini_Lab at @uwmadisonipib and gain @JudithSimcox as co-mentor along the way. Words cannot express how grateful I am for my amazing colleagues, friends, and family who always have my back. Thank you 🙏🏾

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Pagliarini Lab

@Pagliarini_Lab

5 years

Multiple short presentation slots still open for early career scientists. The small meeting size (~150) offers a great chance to interact with prominent members of the field, and the breadth of topics helps us all expand our thinking. #Metabolism

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Pagliarini Lab

@Pagliarini_Lab

5 years

A true giant. Neupert, and many of his academic offspring, have had a hugely positive influence on our field. He will be missed!

Rutter Lab

@RutterLab

5 years

Today on #MitoMonday we mourn the passing of a giant of the #MitoWorld Dr. Walter Neupert, who sadly passed away this past Saturday at the age of 79, we briefly remember his research odyssey that left us all spellbound by #mitochondria . #LateNightWithTheRutterLab

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Pagliarini Lab

@Pagliarini_Lab

6 years

The secret to good metabolism research: have a brother that keeps you well fed!

Michael Pagliarini

@EMPagliarini

6 years

Both @GiuliaCambridge and @b1b_cambridge made the list!

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Pagliarini Lab

@Pagliarini_Lab

6 years

Proud to have our lab alumnus Andrew Reidenbach on this team!

Stuart Schreiber

@SchreiberStuart

6 years

A compelling story from @WIRED of two remarkable patient–scientists, Sonia Vallabh and Eric Minikel ( @cureffi ). Lots of science, humanity and love.

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Pagliarini Lab

@Pagliarini_Lab

6 years

Proud to have one of our own in DC!

Morgridge Institute

@Morgridge_Inst

6 years

Congrats to Danielle Lohman, an alumna of @Pagliarini_Lab , on her #AAAS fellowship! She'll be working in an area of the State Department that deals with issues like biological weapons and #biosecurity @AAAS_STPF @aaas #sciencepolicy

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Pagliarini Lab

@Pagliarini_Lab

6 years

Great to collaborate with @matteodp , @DenizAy07074285 and others on this!

Jonathan Stefely, MD, PhD

@jastefely

6 years

Great work on COQ9 by Danielle et al! @Pagliarini_Lab An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis

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Pagliarini Lab

@Pagliarini_Lab

5 years

We @Morgridge_Inst , in partnership with @UWMadison Biostatistics & Medical Informatics, are looking for a great new computational biologist PI to join our @MorgridgeMeta team. Please see ad below and send along to your colleagues!

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Pagliarini Lab

@Pagliarini_Lab

8 years

Congrats to Xiao, Natalie ( @nieminm ), Adam, and our Coon/Senes lab collaborators on our new @CellReports paper!

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Pagliarini Lab

@Pagliarini_Lab

5 years

Very excited for Rachel and the others, and very grateful to the UMDF! Such a great organization.

United Mitochondrial Disease Foundation

@UMDF

5 years

Congratulations to our Accelerator Prize Winners! You all won. Grand Prize winner Arwen Gao and also Rachel Guerra and Zach Wilson! #MitoMed19 #accelerators #UMDF

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Pagliarini Lab

@Pagliarini_Lab

3 years

CoQ is made in mitochondria, but gets transported to membranes throughout the cell through unknown means. This work implicates two poorly characterized mitochondrial inner membrane proteins in the process.

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Pagliarini Lab

@Pagliarini_Lab

3 years

Very happy to be a part of this. Thanks, @UMDFScience , and congrats again on 25 fantastic years!

Science & Alliance - UMDF

@UMDFScience

3 years

Did you miss the live broadcast of Session 1 of @UMDF Mitochondrial Medicine today? No worries! All meeting registrants have on-demand access to recordings of all conference presentations. Session 2 live on Friday, May 21st. to register.

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Pagliarini Lab

@Pagliarini_Lab

9 years

Pagliarini Lab undergraduate Matt Stefely is heading to UC Berkeley's Molecular & Cell Biology program for graduate school. Congrats, Matt!

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Pagliarini Lab

@Pagliarini_Lab

8 years

Congrats to Jon, Brendan, Mike, and others on their two Molecular Cell papers!

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Pagliarini Lab

@Pagliarini_Lab

3 years

We’d also like to thank @NatureComms and our anonymous reviewers, who provided three tough but very fair and insightful reviews that helped make the paper better. So nice when the peer review process works as it is intended!

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Pagliarini Lab

@Pagliarini_Lab

2 years

@KFW_Lab @Bims_BiomedNews @biorxivpreprint @nieminm and I would love to hear what you think!

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Pagliarini Lab

@Pagliarini_Lab

4 years

@LyssiotisLab @NYASciences @lydfinley Thanks for including such a cancer outsider! I am learning a ton from this great lineup of speakers.

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Pagliarini Lab

@Pagliarini_Lab

4 years

@Nicholas_Lesner @OlzmannLab The GPDH-C/GPDH-M shuttle is perhaps almost what you’re looking for:

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Pagliarini Lab

@Pagliarini_Lab

2 years

This is a great new chapter in your excellent work on copper delivery, Vishal — congrats!

Gohillab

@gohillab

2 years

How do you achieve site (mitochondria)-specific delivery of copper through elesclomol - a copper ionophore? Check out our recent paper that answers this question.

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Pagliarini Lab

@Pagliarini_Lab

3 years

Congrats Davide, Peiling, and Johan! Excited to see this great story in print.

Auwerx Lab

@Auwerx_Lab

3 years

A landmark study led by Peiling Luan and @Davide_D_Amico that shows the significant attenuation of the progression of #Duchenne ’s muscular dystrophy, a lethal muscle disease, by the #mitophagy inducer @UrolithinA was published today in @ScienceTM .

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Pagliarini Lab

@Pagliarini_Lab

4 years

@JasonRCantor @Cell_Metabolism @hankadel @HeatherKPhD @DMSabatini Congrats on this important contribution, Jason et al.! Looking forward to putting HPLM to use in our future work.

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Pagliarini Lab

@Pagliarini_Lab

3 years

@VamsiMootha Thanks, Vamsi! I think my proud @VamsiMootha Lab roots should have been plenty evident by my presentation.

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Pagliarini Lab

@Pagliarini_Lab

1 year

@rahulg603 @jastefely @Nature Super impressive, Rahul! Congrats!

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Pagliarini Lab

@Pagliarini_Lab

5 years

Looking forward to participating in this great NHLBI mitochondrial biology symposium. Call for abstracts still open! #MitoBio2019

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Pagliarini Lab

@Pagliarini_Lab

6 months

@MitoCopper @Zak_Bakes @usask Many thanks for hosting us, Scot! It was great to share our work with the @usask crew and to share the stage with the great @Zak_Bakes . Please send us more like him!

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Pagliarini Lab

@Pagliarini_Lab

5 months

@KatsuFunai @LauraSteenberge Thanks, very glad to hear this! We purchased from Sigma in the past, but Santa Cruz Biotechnology and MedchemExpress also both sell CoQ4.

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Pagliarini Lab

@Pagliarini_Lab

1 year

@PIHanson This was a special honor! So great to be back on campus, meet former colleagues, and see all the ways the department and program have grown. Biological Chemistry is sure in good hands with @PIHanson at the helm!

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Pagliarini Lab

@Pagliarini_Lab

4 years

@JasonRCantor @GIBCO @thermofisher @DMSabatini We've already ordered!

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Pagliarini Lab

@Pagliarini_Lab

9 years

Pagliarini Lab research earns PI Dave a Presidential Early Career Award for Scientists and Engineers (PECASE)!

Pagliarini earns presidential recognition for research on mitochondria

Dave Pagliarini has received the U.S. government’s highest honor for scientists in the early stages of their careers.

news.wisc.edu

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Pagliarini Lab

@Pagliarini_Lab

1 year

I second that, Scot! Stay tuned for more to come from @Zak_Bakes . We'd like to keep him this side of the border, but he'd be a gem for any Canadian University.

Scot Leary

@MitoCopper

1 year

Thanks for sharing Dave! And Canadian Unis look out for @Zak_Bakes who is a super talented PDF who will be looking for Faculty positions north of the border shortly.

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Pagliarini Lab

@Pagliarini_Lab

3 years

@anthonygitter Congrats, Tony! Never a doubt, but great see that it is official. UW and Morgridge are very fortunate to have you.

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Pagliarini Lab

@Pagliarini_Lab

1 year

What a testament to the power and importance of basic scientific inquiry!

The Nobel Prize

@NobelPrize

1 year

“For the 20 years that we worked together before anybody knew about us or cared it was literally the two of us sitting side by side at a bench and working together. Usually at 3 or 5am we would be emailing each other with new ideas.” - 2023 medicine laureate Drew Weissman on