Huang et al. demonstrate different functional states of tumor-reactive CD8+ T cells in the TdLNs where TCF-1+TOX− CD8+ T cells are bona fide memory T cells and function as the genuine responders to...

Nature Biotechnology - CAR T cells engineered to express IL-10 eradicate solid tumors and metastases.

Apoptosis, necroptosis, pyroptosis, and ferroptosis are four forms of regulated cell death in mammalian cells that are controlled by distinctive biochemical pathways and have important physiological...

Nature - IFNγ signalling in epithelial cells promotes antigen presentation that confers intra-epithelial T cells the ability to limit extracellular ATP and consequent NLRP3 inflammasome...

In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and...

Although gasdermins are known to damage mitochondria during pyroptosis, the mechanism responsible and its importance in executing cell death are not known. Here, Miao et al. show that mitochondrial...

Nature Reviews Methods Primers - The adaptive immune receptor repertoire (AIRR) drives adaptive immune responses, which could determine disease outcomes, infectious disease and cancer. Mhanna,...

In humans, senescent fibroblasts do not seem to increase with advancing age in the elderly because their populations are controlled by cytotoxic CD4+ T cells. The expression of T cell-activating...

A bispecific antibody that facilitates physical interactions between conventional type I dendritic cells and CD8+ PD-1+ T cells enhances immune pathways required for aPD-1-mediated response and...

Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting...

Genes & Immunity - Do inhibitory receptors need to be proximal to stimulatory receptors to function?

Nature - Experiments in mice show that a LINE-1 transposable element, Lx9c11, has a functional role in immunity by negatively regulating the response to viral infection to protect the host from an...

Nature Microbiology - This Perspective discusses how viral infections can change inflammation and bone metabolism, leading to diseases.

Experimental & Molecular Medicine - In contrast to earlier beliefs that CD8 T cells primarily differentiate into cytotoxic T cells, recent advances have unveiled the presence of diverse subsets...

Differentiation states are delineated by different cell surface markers for murine and human T cells, which hamper cross-species translation of T cell properties. Zwijnenburg et al. demonstrate that...

Nature Reviews Immunology - The induction of antigen-specific immune tolerance is considered the 'holy grail' of disease management for autoimmunity and organ transplantation. Are we...

Nature Methods - This Review provides an overview of bioinformatic approaches that enable immune repertoire analyses at the single-cell level.

Maternal diet influences infant susceptibility to severe lower respiratory infection, the leading cause of childhood mortality. Sikder et al. demonstrate that a high-fiber diet promotes microbiota...

Nature Immunology - Nimmerjahn and colleagues review posttranslational modification of immunoglobulins and how these posttranslational modifications influence antibody effector function....

Nature Communications - Although IFN-γ is known to regulate T cell function and expansion during virus-specific responses, its impact on T cells with varying avidity for antigen remains...

Nature Immunology - In this Review, Wilfahrt and Delgoffe discuss how T cells integrate nutrient sensing with activating stimuli to shape their differentiation and sensitivity to metabolites.

Senescence induces key phenotypic changes that can modulate immune responses. Four recent publications in Cancer Discovery, Nature, and Nature Cancer highlight how senescent cells (aged normal or...

Nature Communications - Chronic intestinal inflammatory diseases including ulcerative colitis and Crohn’s disease display extensive heterogeneity in the immunopathology, disease manifestation...

Nature Reviews Immunology - Immune cell engagers — antibody-based molecules engineered to direct immune effector cells to recognize and kill cancer cells — represent a rapidly expanding...

Nature Communications - Obesity represents a risk factor for cancer and compromises immune function, however the mechanisms linking the two together are not fully known. Here authors show in a...

Nature Immunology - Chi and colleagues identify brain-resident CXCR6+PD-1+CD8+ T cells that interact with resident microglia to limit immune-mediated pathology in a mouse model of Alzheimer’s...

Nature Communications - Many viral infections are linked to the development of neurological disorders. Here, Balint et al use a mouse model of Zika virus infection to show that it is immune cells...

Communications Biology - A study profiled transcriptomic characteristic of circulating immune cells in preeclampsia pregnancy by scRNA-seq, then develop cell-type-specific models to identify...