John Kastelein @JohnKastelein Twitter profile

Last Seen Profiles

@ArnoldSypho

@venfrn

@t0cZy5ZCoL1418

@JaneatMosaic

@anonymous_yasha

@the_MWIS

@SoHerzi

@KoenMalliet

@Theinstallbrand

@lmfYavRe3442440

@PursueTruth92

@perkdead

@SpartanB005

@palex00_

@monkey_ZmLN

@GegeDNice

@hieumayart

@jsatch6_jknox

@thisputri01

@gilasarmy

@KlaraKocmanova

@san_harumaster

@YuukoFlop

@urownerrayven

@algunamariaa

@raxitosLoR

@UIndyAD

@ark7500

@UkuleleKev

@onyeozuruprince

@nymphss1

@dirty__dan_____

@R16102020

@DulceSanor18075

@butz_bu

@writerbythedark

John Kastelein

@JohnKastelein

1 year

@drpablocorral @RFRedberg @dan_soffer @Drlipid @PeterAttiaMD I doubt statin therapy has cost trillions , after they became generic their costs were reduced to cents … but , more importantly living longer is not the issue , living the last two decades of your life without heart disease should be the prime motivation in my opinion

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John Kastelein

@JohnKastelein

4 months

sdLDL particles are more likely to get trapped in the arterial wall, leading to atherosclerosis. In @NewAmsPharma 's ROSE2 clinical trial, patients receiving a combination of obicetrapib & ezetimibe achieved a >95% median reduction in small LDL-P levels.

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John Kastelein

@JohnKastelein

11 months

Prof Erin Michos delivering her keynote on CETP inhibition at ESC

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John Kastelein

@JohnKastelein

1 year

@BudoffMd He Matt , why would any physician on earth take a 66 year old man off his statin because he has a negative nuclear ?? Makes really no sense at all , even without the results of the nuclear …

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John Kastelein

@JohnKastelein

1 month

Could this be part of the explanation as to why FH patients can have a different clinical course wile rxposed to the same LDL-C levels ?

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John Kastelein

@JohnKastelein

1 month

#EAS congress2024 ; sharing a table with our fabulous President , Prof Kosh Ray !

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John Kastelein

@JohnKastelein

2 years

Nothing as important as constructing a family tree and find new patients that can be treated in the best possible way 😊. We showed this for the first time in 2001 in Lancet and now in 2022 the ticker indicates at least 35.000 heFH patients 🇳🇱

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John Kastelein

@JohnKastelein

2 years

This is my daily routine , my home gym in the old horse stable that came with this 1917 home ..💪

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John Kastelein

@JohnKastelein

4 months

I'd argue that LDL-C is a quality-of-life metric given its impact on cardiovascular risk--whether it's formally recognized or not. Well said, @CBallantyneMD .

NewAmsterdam Pharma Corporation

@NewAmsPharma

4 months

@JACCJournals Advances reports only ~30% of Medicare beneficiaries had their LDL-C measured within 90 days of treatment for a heart attack. @CBallantyneMD shares how reinstating LDL-C as a quality metric could not only reduce CVD burden but also help reduce healthcare inequities.

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John Kastelein

@JohnKastelein

2 years

@Drlipid There is only one true causal risk factor for ASCVD ; an apoB containing lipoprotein … all the rest are permissive or bystanders but never conditional ….that does not detract from the fact we combat the latter without mercy , but it helps to understand where to strike first 🤛

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John Kastelein

@JohnKastelein

7 months

@NewAmsPharma @WUSTLmed More and more evidence is emerging that accumulation of cholesterol and its esters in brain cells are an early phenomenon of apoE4 carriers , the most important risk factor for Alzheimer’s … so , toxic sterols>inflammation> neurodegeneration is a pathway we now can research

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John Kastelein

@JohnKastelein

3 months

In @NewAmsPharma 's ROSE2 trial, we observed a median 63.4% reduction in LDL-C among participants taking a combination of our #CETP inhibitor, obicetrapib, and ezetimibe. Our Phase 3 TANDEM study will examine the two in a fixed-dose combination.

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John Kastelein

@JohnKastelein

2 months

As with all medical matters, you’re your own best advocate. If it’s been a while since your last lipid panel, ask your doctor if it’s time to check your levels. Lower LDL-C for longer is better. #NationalLipidDay

NewAmsterdam Pharma Corporation

@NewAmsPharma

2 months

Healthy adults should have their cholesterol checked at least once every 5 years. This #NationalLipidDay , learn how to read your lipid panel with help from @foundationofnla :

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John Kastelein

@JohnKastelein

1 year

@Drlipid I always say ; kids with heFH basically have no side-effects on statins ; they do not read inserts or anti-cholesterol books nor do they see misery on the internet ..,

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John Kastelein

@JohnKastelein

1 year

Enjoying the Presidents dinner with the Nicholls family , Christie Ballantyne at fantastic EAS !

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John Kastelein

@JohnKastelein

7 months

@BenBikmanPhD There is good evidence that , next to insulin resistance , the storage of cholesteryl esters in lipid droplets within microglia , astrocytes and neurons is also a very early feature of the path towards Alzheimer’s, especially in apoE4 carriers .. so , many similarities to CAD

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John Kastelein

@JohnKastelein

1 year

@WillBrink @drpablocorral @lipo_fan @Drlipid @alavallecobo @pabeda1 @BNordestgaard @realDaveFeldman @dan_soffer I definitely agree , with Peter Libby and Paul Ridker , that inflammation needs to be adressed in cardiometabolic disease , but CRP is not the target ; these are o.a. Interleukin-1beta and Il-6 ..the reduction in hsCRP is a consequence of hitting these targets

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John Kastelein

@JohnKastelein

1 year

@drpablocorral @lipo_fan I woukd like to debunk 4 myths ; 1.Lowering of TG rich lipoproteins reduces ASCVD risk even when apoB does not move 2. There is an U shaped curve for LDL-chol and mortality .. 3. There is an U shaped curve for HDL -chol and mortality 4. High HDL is a risk factor for dementia

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John Kastelein

@JohnKastelein

9 months

@drscottyk Hi Scotty , that incidence of type II DM is just significant , and the cataract data are nonsense , so I am going to stick with my Crestor 10/Eze 10 scheme I have been on for ages ….😅

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John Kastelein

@JohnKastelein

7 months

@NutritionMadeS3 Thanks Gil , one of the studies I am most proud of … especially the astonishing safety …

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John Kastelein

@JohnKastelein

8 months

@LowCarbEyeDoc @ann_seclow @realDaveFeldman @Drlipid @calmdiscuss @drpablocorral @lipo_fan @lansberg Ok , lets have it on X … Dave , can we first define the contentious issues surrounding the LMHR phenotype ? Once we have those crisp and clear we can take a deep dive , while our vigilant watchdogs , drs Dayspring and Corral , do a bullshit check from the sidelines 😅

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John Kastelein

@JohnKastelein

9 months

@pnatarajanmd @DiabetesCareADA Again this RCT shows the pitfalls of observational epidemiology ; whatever you attempt to control for , there is always residual confounding and even reverse causation ( low LDL and all-cause mortality ) no matter how large the cohort …

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John Kastelein

@JohnKastelein

9 months

@mdavidsonmd I wholeheartedly support that Michael ; random killing of young people at a music festival is atrocity at its worst … Hamas is not only killing our Jewish friends by the way , they also throw members of the LHBTQ community from the rooftops …

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John Kastelein

@JohnKastelein

1 year

@Drlipid @rosspearl @Chooi @PlantChompers @NutritionMadeS3 And still by far the most relevant observation : children who do not smoke , have no diabetes , no hypertension , are not obese , have low CRP and Il-6 ,low Lpa ( not always of course ) , healthy teeth , but do have two mutations in the LDL-rec gene , have athero in Kindergarten

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John Kastelein

@JohnKastelein

11 months

@Drlipid @ann_seclow @drpablocorral @NordestgaardLiv @BNordestgaard @dan_soffer @ATHjournal @society_eas @pabeda1 Look at this paper Tom … it is maybe not entirely apoB

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John Kastelein

@JohnKastelein

5 months

@DrNadolsky If you keep training in the gym when on Ozempic ; no loss of muscle mass , but if you are a couch potato and on Ozempic , chances are pretty high you will loose muscle mass 💪

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John Kastelein

@JohnKastelein

4 months

@TheFHFoundation I could not agree more with Henry ! Fortunately , in Europe and Canada we kept our head cool … right after the cancellation of LDL targets in the US , CV mortality rose again : a blunder of epic proportions !

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John Kastelein

@JohnKastelein

8 months

@neeche41 @realDaveFeldman @Lipoprotein @drpablocorral @BudoffMd Debate is essential for medicine but it should be polite and based on scientific facts … science is never finished , things we now strongly believe in are laughed at in the future, so modesty serves all 😇

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John Kastelein

@JohnKastelein

4 months

@SBakerMD Did you get a TG reading at the same time ? Sometimes , total cholesterol levels can vary immensely together with massive differences in chylomicrons ..

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John Kastelein

@JohnKastelein

6 months

@Drlipid @nationallipid @society_eas That is superexciting ! We wrote a meta-analysis on the effect of CETPi and new-onset DM and found a consistent 16% decrease of NODM incidence . Our hypothesis ; the robust apoA1 increase is what connects ALL CETPi and apoA1 protects the beta-cell .

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John Kastelein

@JohnKastelein

4 months

@drscottyk In patients with insulin resistance that are on high intensity statins LDL particle distribution has shifted to small particles and in that situation LDL p might be a better indicator of risk than apoB … beware ; this is my personal hypothesis …

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John Kastelein

@JohnKastelein

2 years

Having good thoughts about the last 5 days ! #mdavidsonmd

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John Kastelein

@JohnKastelein

1 year

@kardiokoeln I eat two eggs every day , 7 days a week … the authors forgot to mention lutein , also present in egg yolk and an important anti-oxydant , transported from liver to eye by HDL particles , where lutein ends up in the macula to protect against UV radiation and macula degeneration

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John Kastelein

@JohnKastelein

1 year

@stevesphd @ArsenaultBenoit @ehj_ed @EliasBjornson All very nice , but in PROMINENT both TG rich lipoproteins as well as remnants were robustly lowered and it did nothing for outcomes …. Please remember LpPLA2 ….observational data ≠randomized outcome data

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John Kastelein

@JohnKastelein

6 months

@Drlipid @nationallipid @society_eas obicetrapib indeed increases total apoA1 by an unparalleled 60% and raises the concentration of lipid-free apoA1 , pre-beta1 and pre-beta2 HDL significantly too . And those particles , because of their size , have access to any tissue ; pancreas , eye , brain and arterial wall

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John Kastelein

@JohnKastelein

3 months

@TuckerGoodrich Butter by far !!

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John Kastelein

@JohnKastelein

1 year

@TIMIStudyGroup That is what we all thought ! Hope the rebuttal is fierce 🤛

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John Kastelein

@JohnKastelein

11 months

@Drlipid @ingold22 @dan_soffer @RZubiranS @drpablocorral @caguilarsalinas @Lipoprotein @lipo_fan @drscottyk I feel ashamed when I see the ENHANCE trial of ezetimibe mentioned in a pub .. I failed to measure baseline cIMT first and therefore missed that my heFH patients were well treated and had a near normal cIMT and therefore there was nothing to regress ; a false negative trial 🥲

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John Kastelein

@JohnKastelein

8 months

@calmdiscuss @drpablocorral @lipo_fan @Drlipid I think when you wait long enough they will get it ; LDL X Years = ASCVD

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John Kastelein

@JohnKastelein

1 year

@Drlipid And , most importantly these are randomized controlled studies and not observational data where reverse causation makes it look like low LDL-C leads to increased CV mortality 👏

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John Kastelein

@JohnKastelein

2 years

@Drlipid @society_eas @nationallipid @PeterAttiaMD This U shaped relationship is “ discovered “ by scientists and Journals with a short memory … it was reported 4 decades ago and then as now it is explained by residual confounding .. Am adressing this in a new analysis of the Epidemiology as well as the Trial data …,

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John Kastelein

@JohnKastelein

2 years

@LiutaurasJuska @DBelardoMD @Drlipid In fact , there is no LDL-hypothesis anymore ; the ESC/EAS has indicated this now has gone over to the LDL-axioma …: Mendelian randomiz, genetics ( FH ) , biology and clinical trials constitute the largest evidence base in current medicine to support this statement

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John Kastelein

@JohnKastelein

3 years

@Drlipid @society_eas Hi Thomas , intriguing data indeed ; the second part of the findings is echoed by the recent and great paper by Allan Sniderman and colleagues in JAMA Cardio ; apoB is the most important data point ,nothing much is additive …

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John Kastelein

@JohnKastelein

6 months

@NutritionMadeS3 My family was liberated from a 5 year tyrannical occupation by American soldiers who fought their way through Europe to bring freedom and bread to a starving Dutch population… my grandmother hid Jewish families from the Nazi’s ; I will always be grateful to the US …

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John Kastelein

@JohnKastelein

5 months

@Drlipid @DrMichaelShapir @ASPCardio @society_eas @nationallipid @atherosociety Moreover , the PROMINENT trial , with a fibrate that lowered remnant cholesterol by 30% , had no MACE reduction …so , in this case I agree with Thomas ; show me an RCT with an anti-apoCIII agent for example , on top of statins , that shows MACE benefit and I will be convinced

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John Kastelein

@JohnKastelein

6 months

@Drlipid @PeterAttiaMD And this confounding is exactly the reason why high HDL in observational studies has this bizarre relationship to dementia , all cause mortality and CV mortality … all nonsense

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John Kastelein

@JohnKastelein

1 year

@Drlipid Dr Lipid is right on the dot : we found a family with a mutation in SRB1 in Amsterdam and when we performed ACTH testing , those with the mutation had flatter cortisol responses than healthy siblings , proving that HDL carries chol to the adrenal and not LDL !

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John Kastelein

@JohnKastelein

7 months

@Drlipid @drpablocorral @maciejbanach @pabeda1 @rauldsf_santos @CBallantyneMD @SABOURETCardio 1 plus 1 = 3

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John Kastelein

@JohnKastelein

1 year

@BrezanSimonMD I am so happy you directed our attention to this publication which puts an end to lousy observational data that still come up with an U shaped curve for LDL and mortality …all residual bias and confounding … the same applies to the U shaped curve of HDL and mortality …

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John Kastelein

@JohnKastelein

2 years

@pabeda1 @ProfKausikRay @DLBHATTMD @ProfSNicholls @AL_Catapano Yeah Sergio , it does support Brian’s work or the logic could be ; not enough apoB reduction to yield a meaningful result for MACE …

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John Kastelein

@JohnKastelein

6 months

@drpablocorral @Drlipid 100% sure ; xanthelasmata

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John Kastelein

@JohnKastelein

1 year

@drpablocorral @Drlipid @lipo_fan @alavallecobo @society_eas @pabeda1 Hey Pablo , that’s right , we performed similar experiments even earlier !

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John Kastelein

@JohnKastelein

10 months

@drpablocorral I would like to warn against the feeling ; “ been there , done that “ … let there be some room for debate !

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John Kastelein

@JohnKastelein

4 months

@nicknorwitz @ethanjweiss @Lipoprotein @drpablocorral @AllenGreenMD1 @DrNadolsky @lipiddoc But , Nick , increased LPL activity is the most desirable thing to have in terms of cardiometabolic health , rapid turnover of TG rich lipoproteins , rapid generation of lots of prebeta HDL particles , rapid remnant uptake ( LPL is also a ligand for liver receptors ) and …

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John Kastelein

@JohnKastelein

1 year

@Drlipid “ Obi -wan -kenobi “ means “ my heart “ in Iqbo , the official language of Nigeria and “ obi “ means “ heart “ 😅

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John Kastelein

@JohnKastelein

2 years

@Drlipid @NutritionMadeS3 I agree with Thomas that raising HDL-C does NOT reduce MACE , but it might be related to a reduction of the onset of new diabetes as hypothesized in a post-hoc analysis of Dal-Outcomes by Greg Schwartz . We will test this prospectively in our obicetrapib CVOT , PREVAIL

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John Kastelein

@JohnKastelein

3 months

@drpablocorral Fantastic support for the hypothesis that obicetrapib by increasing the synthesis of apoA1 might play a beneficial role in neurodegeneration , thanks Pablo , I had not seen this paper yet …

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John Kastelein

@JohnKastelein

2 years

@FoodyMD Fantastic JoAnne and Sheldon ; this is what the field and the patients really needed , my warmest congrats 🎈🍾 for this great achievement !!

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John Kastelein

@JohnKastelein

4 months

@nicknorwitz @ethanjweiss @Lipoprotein @drpablocorral @AllenGreenMD1 @DrNadolsky @lipiddoc And , if the theory is depletion of glycogen stores in the liver , then increased VLDL export makes no sense , in contrast , I would expect decreased VLDL production … a liver with less energy stores does not export its most valuable energy carrier , which are TG’s …

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John Kastelein

@JohnKastelein

3 months

@TuckerGoodrich Grass fed cows ( especially Jersey ) produce a full milk and butter of great fatty acid composition… humans have consumed butter for eons whereas margarine is basically hydrogenated fat for which in my country they used offal as its basis ; everyone decides what they like best

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John Kastelein

@JohnKastelein

9 months

@NutritionMadeS3 Observational , residual confounding , no LDL or HDL available , uncorrected for medication , alcohol , cancer … has no meaning at all

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John Kastelein

@JohnKastelein

6 months

@NutritionMadeS3 I would stick with science Gil , that is your education ..

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John Kastelein

@JohnKastelein

8 months

@realDaveFeldman I have a hard time believing the red meat and salt connection to the occurrence of diabetes .. first , observational data on diet are hopelessly confounded and second what is the biology here ?

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John Kastelein

@JohnKastelein

3 months

@RosenelliEM @paulsaladinomd @Drlipid @MohammedAlo In Amsterdam I had tons of patients with heFH who suffered from a heart attack before the age of 40 …

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John Kastelein

@JohnKastelein

1 year

@Drlipid Beautiful review and this Table I often use as an “ opening shot “ in my academic lectures 😅

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John Kastelein

@JohnKastelein

2 years

@Drlipid @society_eas Indeed beautiful Editorial …. Follows in the footsteps of Allan Snidermann and many others that have highlighted the greater precision of apoB , especially against the background of the obesity and diabetes epidemic currently on the rampage across the globe !

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John Kastelein

@JohnKastelein

10 months

@drpablocorral @Drlipid @dan_soffer @BNordestgaard @OxPL_apoB @ProfKausikRay Ab-so-lute-ly 😅

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John Kastelein

@JohnKastelein

1 year

@Drlipid @drpablocorral @dan_soffer @soonergise @lipo_fan @lipiddoc @society_eas @LipidosSal @alavallecobo @lschreier1 @realDaveFeldman This is a fantastic insight ! The fact that some VLDL’s have apoB48 instead if apoB100 when they come out of the liver was entirely new to me before #drLipid told me about it .. perhaps that is the reason that in a number of DM2 trials LDL-P tracks better with CAD risk than apoB

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John Kastelein

@JohnKastelein

1 year

@skathire @dmljmd @JACCJournals But , Sek , this is observational , I thought we were done with TG rich lipoproteins after 3 decades of failed trials with PROMINENT as most important example 🤔

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John Kastelein

@JohnKastelein

4 months

@AaronGuidice99 @Drlipid @theproof It did , and robustly so , but there will always be the overhang of the choice of placebo ( mineral oil versus a more inert oil ) so there are two sides in medicine now ; dr Deepak Bhat versus drs Nissen and Ridker on the issue of mineral oil … we need a new trial to solve this

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John Kastelein

@JohnKastelein

1 month

@drpablocorral But , my friend , it might be at least a beginning of an explanation as to why , even in the same family , FH patients can have such different clinical paths ..,

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John Kastelein

@JohnKastelein

1 year

@lipo_fan @WillBrink @drpablocorral @Drlipid @alavallecobo @pabeda1 @BNordestgaard @realDaveFeldman @dan_soffer Exactly …. Novo acquired a human monoclonal Ab against Il-6 for a number of cardiometabolic disorders and a host of small /medium Biotech companies is working on inflammazome inhibitors for a variety of disorders , also outside cardio …

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John Kastelein

@JohnKastelein

4 months

@PamTaubMD Couldnt agree more Pam ; the deep pitfalls of observational data !

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John Kastelein

@JohnKastelein

4 months

@nicknorwitz @ethanjweiss @Lipoprotein @drpablocorral @AllenGreenMD1 @DrNadolsky @lipiddoc In fact , the only good reason for LMHR is a downregulation of LDL receptors at an epic scale , so that’s where we need to find an explanation .. Could PCSK9 levels have gone up , is SREBP dysregulated , somehow the liver must sense thst cholesterol pools are overflowing ; why ??

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John Kastelein

@JohnKastelein

1 year

@SABOURETCardio Finally something new and exciting in the blood pressure space that has been intellectually comatose for a very long time ! Next to the aldosterone synthase inhibitors we now get an angiotensinogen blocker that silences the RNA for 6 months ! Hurray 🎉

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John Kastelein

@JohnKastelein

9 months

@Drlipid @society_eas @nationallipid It is possible that for LDL lowering to work as prevention of Alzheimer , you need to start really early in life , like in your 40ties and that has not been tested ..

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John Kastelein

@JohnKastelein

2 years

@maciejbanach @GaronGenevieve @ehjopen @PinkasJJ @AgataBieleckaD @AlNiewiadomska @BenszJoanna @ehj_ed @CiccaroneCenter @ewa_kurzynska He Maciej , there are “ longevity “ genes enough to work with and loss-of-function CETP is one of them ! I am hugely interested in this subject ..

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John Kastelein

@JohnKastelein

2 years

@Drlipid ApoE is an important apolipoprotein ; would it be outrageous to hypothesize that lipid metabolism in the brain has consequences for Alzheimer’s?

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John Kastelein

@JohnKastelein

8 months

@drpablocorral But , Pablo , I find the distinction a bit artificial .. first , there are many more LDL’s than remnants and second , look at apoCIII lowering ; large effect on remnant chol , very small effect on apoB and increases LDL ; will that be good for athero ?

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John Kastelein

@JohnKastelein

2 years

It was an amazing experience to witness the energy , see the crows , feel the excitement and enjoy great science first-hand instead of staring at a screen in your basement ! ESC set the standard again 😅

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John Kastelein

@JohnKastelein

10 months

@JamalRanaMD @AHAScience @HeartBobH @ACCinTouch @jgharoldmd @escardio @ESC_President @Steph_Achenbach @DrMarthaGulati @AnkurKalraMD @timir_paul @biljana_parapid @AnastasiaSMihai @Hragy @pabeda1 @SanChris999 @adityadoc1 @Drroxmehran @UvA_Amsterdam @DrNathanWong @HanCardiomd @purviparwani @HiteshiKc @docbhardwaj @rohan_khera @dramitkhera @EugeniaGianos @khurramn1 You are too generous Jamal , I deeply enjoyed the time you worked with us and I learned from you as much as we learned from you in old Amsterdam !

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John Kastelein

@JohnKastelein

6 months

@DocSavageTJU @ErinMichos @DrMarthaGulati @DrRachelMBond @mmamas1973 @djc795 @DBelardoMD @iamritu @lipiddoc @MinnowWalsh @rblument1 @AnastasiaSMihai @hvanspall @VietHeartPA @fischman_david @TheLancet Another hopelessly confounded observational study ..” what is intricately linked in biology cannot be unraveled by statistics, however hard you try “

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John Kastelein

@JohnKastelein

11 months

@CBallantyneMD @TheFHFoundation @nationallipid @CMHC_CME @BCMHeart

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John Kastelein

@JohnKastelein

3 years

@CBallantyneMD @ProfSNicholls @dkling @skathire @CMichaelGibson @AnnMarieNavar @ProfKausikRay @mdavidsonmd @FoodyMD Hi Christie , I have to be honest with myself ; I am from a different era … I started Med school in 1972 and there we were taught that “ normal “ cholesterol was any value below 300 mg/dl , FH was treated by dermatologists and our toolkit had Atromid-S , Questran and Niacin .

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John Kastelein

@JohnKastelein

1 year

@MeralKayikcoglu @lipo_fan @LaleTokgozoglu @lipiddoc @BNordestgaard @pabeda1 @drpablocorral @ErinMichos @lansberg @geraldwatts Xanthelasmata can be present at different ages without any connection to heFH or any other lipid disorder .. they even can be hereditary without any other underlying disorder …

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John Kastelein

@JohnKastelein

3 years

@ProfSNicholls @dkling @CBallantyneMD @skathire @CMichaelGibson @AnnMarieNavar @ProfKausikRay @mdavidsonmd @FoodyMD A warm “ thank you note “ is in order to all the wonderful colleagues who have welcomed me to the Twitter world ; truly a new but exciting opportunity for me to read , share , applaud and initiate novel science in Lipids and Cardiometabolic disease …

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John Kastelein

@JohnKastelein

10 months

@skathire @Paddy_Barrett In some studies there is even a suggestion of superiority of non-HDL over apoB , especially if the patient has large numbers of small LDL particles in which apoB mass might be less ; diabetic dyslipidemia much constitute such an example , but the books are not closed on this yet

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John Kastelein

@JohnKastelein

1 year

@SABOURETCardio Friedewald is good till an LDL-c of about 50mg/dl .. but Martin-Hopkins is better .. and Friedewald also stops being accurate at much lower TG levels than we previously thought ( 150 versus 450 mg/dl ) , also in this situation Martin-Hopkins is better ..

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John Kastelein

@JohnKastelein

4 months

@drpablocorral @society_eas In my opinion there are just as many studies showing a slight increase of hsCRP after ezetimibe as a slight decrease … of course I support the decreases after statins and BA , but I doubt the eze data

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John Kastelein

@JohnKastelein

2 years

@LiutaurasJuska @BeratBrah @DBelardoMD @Drlipid Just read our JAMA paper in 2017 ; Ference , Kastelein et al , per 10 mg/dl absolute LDL reduction we provide the OR’s for MACE with proxy’s for Statins , PCSK9 Mab’s , Ezetimibe and CETPi ; exactly the same !

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John Kastelein

@JohnKastelein

9 months

@CMichaelGibson Invest in Apple

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John Kastelein

@JohnKastelein

2 years

@prabhud19 @Lpa_Doc @Lipidaoi1 @ExpertLipid @DrRajeevagarwa3 @DrNathanWong @DrAltamashS @LaleTokgozoglu @rauldsf_santos @atherosociety @MeralKayikcoglu I would add Evinacumab to her regimen , the quadruple therapy for these patients; HIS plus ezetimibe plus Evolocumab plus Evinacumab is the best we currently have to combat LDL receptor deficiency …

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John Kastelein

@JohnKastelein

1 year

@MeralKayikcoglu @DrMarthaGulati @KemalogluOz @FrancescoPaneni @biljana_parapid @alaide_chief @iamritu @drozgeozden @NurglKeser6 @LaleTokgozoglu @FGraziani_Grace @drmilicaa @SilbermanManzo @StellEkaterina Hi Meral , what an incredible disaster has struck the people of Turkey 🇹🇷… we all feel with you … Dutch search and rescue teams have landed in Turkey yesterday and money and goods collection is ramping up fast … we are going to help !

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John Kastelein

@JohnKastelein

4 months

@ethanjweiss @realDaveFeldman @nicknorwitz @AdrianSotoMota @infeldMD @Lipoprotein @drpablocorral @AllenGreenMD1 @DrNadolsky @lipiddoc So , we need to understand why LDL-C goes up by so much in some folks … no way out of this conundrum but a turnover study

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John Kastelein

@JohnKastelein

2 years

@FoodyMD Sky and Lilo on the couch for a rest moment after a sturdy walk ! 😅

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John Kastelein

@JohnKastelein

3 years

@SABOURETCardio @pabeda1 @ProfSNicholls @mdavidsonmd Friends , the “ trapib “ with a positive effect on MACE was anacetrapib in REVEAL ; NEJM reported the 4 year follow up and recently Eur Heart J the 6.4 year follow up … torcetrapib had off target effects , dalcetrapib did not lower LDL -c , so now it is up to obicetrapib !

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John Kastelein

@JohnKastelein

11 months

@LDLSkeptic @thalesnemo @ProfTimNoakes @DoctorTro @DominicDAgosti2 @lowcarbGP @SBakerMD @ethanjweiss @davidludwigmd @DrAseemMalhotra @TheFHFoundation @KenDBerryMD Same primary school reasoning as ; Winston Churchill lived till 90 and smoked cigars till he died and abused alcohol ; let’s all do that and live a long and happy life …. I am sure it is a lot of fun to have a contrary opinion , but at some point it becomes just vanity …

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John Kastelein

@JohnKastelein

2 months

@TuckerGoodrich @DrEenfeldt That is where I trained Tucker , UBC in Vancouver .. Jiri Frohlich has passed , but Simon Pimstone and Michael Hayden are still alive and kicking ? And I am sure the conclusions are correct ; reversing it is another story ..

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John Kastelein

@JohnKastelein

1 year

@Drlipid Mendelian randomization data offer low CETP activity haplotypes as protective against the ravishes of apoE4 carriership … we hope that raising apoA1 in the circulation by obicetrapib might translate into raising apoA1 in CSF as well ..and apoA1 can substitute for defective apoE4

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John Kastelein

@JohnKastelein

2 years

@drpablocorral He Pablo , very nice of you to pick this up so fast ! You can imagine how excited we are about this in light of the increase in new-onset diabetes conferrred by statins ; these data make the statin-CETPI combo even more attractive 😊

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