Cigall Kadoch @CKadoch Twitter profile

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Cigall Kadoch

@CKadoch

3 years

A whirlwind of excitement these past couple of days! I am deeply honored and humbled to receive this @HHMINEWS recognition and award. Big thanks to all @kadochlab @DanaFarber members, past and present, who have made this possible! To the next 7 years and beyond! #science 🙏🙏

HHMI NEWS

@HHMINEWS

3 years

HHMI News: We are proud to announce our 33 new #HHMIInvestigators . These individuals have the potential to make transformative discoveries over time and we look forward to seeing where their ideas lead them.

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Cigall Kadoch

@CKadoch

3 years

Excited to see this new work from our lab @kadochlab and @MuirLab out in @ScienceMagazine @aaas today uncovering the impact of chromatin landscape signals on the targeting and activities of mSWI/SNF family complexes! @NMashtalir @ongnghiem

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Cigall Kadoch

@CKadoch

9 months

Thank you @MSKCancerCenter for this incredible honor of the 2023 Paul Marks Prize! I am grateful to receive this alongside two other brilliant investigators and friends. My teams will continue on our mission to advance novel biology to new medicines for patients with #cancer .

Memorial Sloan Kettering Cancer Center

@MSKCancerCenter

9 months

Congratulations to this year’s recipients of the 2023 Paul Marks Prize for Cancer Research: Dr. Mark Agnel Frederick Dawson, Dr. Cigall Kadoch, and Dr. Michelle Monje-Deisseroth. Read more:

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Cigall Kadoch

@CKadoch

5 months

Incredibly honored and humbled to receive the #PaulMarksPrize today in NYC @MSKCancerCenter ! Beautiful medal ceremony & luncheon, inspiring symposium, and thrilled to share this Prize with two extraordinary colleagues and friends, @MAF_Dawson & @michelle_monje ! @DanaFarberNews

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Cigall Kadoch

@CKadoch

5 years

Thank you, @sciencemagazine for this wonderful honor- I look forward to delivering the award lecture at the @NIH next month! And most importantly, congrats to all @kadochlab members - it is their brilliant work that is being recognized.

Science Magazine

@ScienceMagazine

5 years

Congratulations to Cigall Kadoch ( @ckadoch , @kadochlab ) from @DanaFarber on winning this year’s AAAS Martin and Rose Wachtel Cancer Research Award for her work on chromatin remodeling in cancer. @ScienceTM

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Cigall Kadoch

@CKadoch

4 years

Thank you, @AACR for this huge honor. I am deeply humbled and look forward to delivering the award lecture describing our lab’s newest advances next year! @kadochlab @DanaFarber @broadinstitute @harvardmed #cancer #cancerresearch

AACR

@AACR

4 years

The AACR honors Dr. Cigall Kadoch with the 2020 AACR Award for Outstanding Achievement in Basic Cancer Research. #AACR20

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Cigall Kadoch

@CKadoch

1 year

Happy to see our work on #Tcells #CART out today in @MolecularCell ! Great collaboration with my good friend and colleague, @iannisaifantis1 as we worked out the role for #BAFcomplexes in mediating T cell #exhaustion .

Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and...

mSWI/SNF ATP-dependent chromatin remodeling complexes direct chromatin accessibility and gene expression during T cell activation and exhaustion. Targeting mSWI/SNF complexes with clinically relevant...

www.cell.com

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Cigall Kadoch

@CKadoch

4 years

Extremely honored and humbled today to be named a Blavatnik National Awards finalist among these talented peers. My laboratory members and I look forward to many productive and exciting years to come! @BlavatnikAwards @DanaFarberNews @broadinstitute @harvardmed

Blavatnik Awards

@BlavatnikAwards

4 years

Congratulations to the 2020 Finalists of the Blavatnik National Awards! @ckadoch @kadochlab @danafarber @broadinstitute @harvardmed @Harvard @Shenvi_lab @scrippsresearch @UTCompSci @TexasScience @UTAustin #Blavatnik2020

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Cigall Kadoch

@CKadoch

4 years

Thrilled and honored to have had the opportunity to ring the @Nasdaq opening bell this morning in Times Square, in celebration of @foghorntx , Inc going public! 🎉🎉 #FHTX #FoghornTxIPO ! Here’s to all that lies ahead in delivering new, first-in-class medicines to patients.

Nasdaq Exchange

@NasdaqExchange

4 years

Welcome to the @Nasdaq family, @Foghorntx ! 👏👏👏 Foghorn Therapeutics, #NasdaqListed as $FHTX, is discovering and developing an unprecedented class of medicines using their proprietary Gene Traffic Control™ Product Platform. #FoghornTxIPO

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Cigall Kadoch

@CKadoch

4 years

Huge congratulations, @kadochlab and our Walz, DiMaio, Ranish, Roeder and He lab collaborators on a job well done! Great to see this 5+ year effort published! @NMashtalir @akshaysci

Cell

@CellCellPress

4 years

New Article now online: A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

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Cigall Kadoch

@CKadoch

5 years

Huge congratulations to my talented graduate student, @FreddyMValencia and our colleagues in the @kadochlab , @Muirlab and @DanaFarber ! Exciting new paper on a critical interface between the human mSWI/SNF (BAF) chromatin remodeling complex and nucleosomes that governs activity.

Cell

@CellCellPress

5 years

New Article online now at Cell: Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

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Cigall Kadoch

@CKadoch

3 years

A major milestone for @foghorntx (NASDAQ: FHTX) and our field at-large in dosing the first patient with a new class of small molecules targeting chromatin remodeling complexes. FHD-268 targets the BRG1/BRM ATPases of the mSWI/SNF complexes. Grateful to our team and patients.

Foghorn Therapeutics

@foghorntx

3 years

Today, we announced the first patient was dosed in our FHD-286 #clinicaltrial , a key milestone in our mission to change the lives of those with serious diseases. This is the first candidate from a new drug class targeting the #chromatin regulatory system:

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Cigall Kadoch

@CKadoch

5 years

Thank you, @sciencemagazine for this incredible honor. Grateful for my brilliant colleagues in the @kadochlab @DanaFarber and our fantastic collaborators world-wide.

Science Magazine

@ScienceMagazine

5 years

Congratulations to Cigall Kadoch ( @ckadoch , @kadochlab ) from @DanaFarber on winning this year’s AAAS Martin and Rose Wachtel Cancer Research Award for her work on chromatin remodeling in cancer. @ScienceTM

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Cigall Kadoch

@CKadoch

4 years

Thank you @CellCellPress ! We are excited to see this out online! @kadochlab

Cell

@CellCellPress

4 years

Online now! #Structural analysis of an endogenous #human SWI/SNF #complex provides insight into how #cancer -associated #mutations affect the remodeler’s #function .

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Cigall Kadoch

@CKadoch

6 years

Congratulations, @kadochlab on a major study unraveling the modular organization and assembly of mSWI/SNF chromatin remodeling complexes- new views in to disease mechanisms!

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Cigall Kadoch

@CKadoch

1 year

Thank you, @DanaFarberNews @DanaFarber @harvardmed ! Extremely honored to be named a Finalist for the @BlavatnikAwards @NYASciences National Awards.

Dana-Farber

@DanaFarber

1 year

Congratulations to @DanaFarber ’s Cigall Kadoch, PhD, and Eric S. Fischer, PhD, finalists for the 2023 Blavatnik National Awards for Young Scientists which honor outstanding scientists and engineers under the age of 42. @blavatnikawards @NYASciences

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Cigall Kadoch

@CKadoch

5 months

A great pleasure to Chair and speak in the #AACR24 @AACR Major Symposium on #Epigenetics and Chromatin Regulation in Cancer! Packed house, exciting science, and fantastic presentations by my two colleagues and friends, @Yael_David__ and @ArulChinnaiyan !

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Cigall Kadoch

@CKadoch

3 years

Very excited to share that the second major program at @foghorntx , FHD-609, is now in the clinic! This one hits extra close to home as our initial studies in #synovial #sarcoma are what catalyzed a new understanding of the large class of cancers and other diseases driven by BAF.

Foghorn Therapeutics

@foghorntx

3 years

Today, we announced the first patient was dosed in our #clinicaltrial for FHD-609, being developed for the treatment of #synovialsarcoma . This important milestone marks our first protein degrader & second pipeline candidate to enter the clinic: $FHTX

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Cigall Kadoch

@CKadoch

4 months

A moving evening to celebrate 4 decades of science for legend Stu Orkin earlier this week. Stu hired me to @DanaFarber @BostonChildrens and I have been ever inspired by his commitment to basic science toward discoveries that will benefit many. Bravo and thank you, Stu!

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Cigall Kadoch

@CKadoch

1 year

Exciting new study from our @kadochlab @DanaFarber @HHMINEWS @harvardmed @broadinstitute and Aviv Regev’s lab using #perturbseq and #shareseq to define contributions of mSWI/SNF #BAF subunits, modules, and combinatorial assemblies to gene expression. #chromatin

Kadoch Lab

@kadochlab

1 year

Congratulations to @chemical_phd @kadochlab student, Jordan Otto Jagielski, @oana__ursu and @alexpywu on their exciting new @MolecularCell paper! Great collaboration with Regev lab using Perturb-seq to define functions of mSWI/SNF subunits and modules.

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Cigall Kadoch

@CKadoch

5 months

Happy to be hosting @AbdelWahablab from @MSKCancerCenter today at @DanaFarber for the Rose Winer Levin Lecture of our Seminars in Oncology series! #RNAsplicing #cancer

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Cigall Kadoch

@CKadoch

5 years

A big thank you to everyone for the tweets, emails and messages about the @aaas Wachtel Prize- I am very grateful to receive this honor and look forward to all that the @kadochlab has in store in the coming years!

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Cigall Kadoch

@CKadoch

2 months

Great to participate in and share recent @kadochlab studies at @GordonConf #GRC24 on Chromatin Structure and Function in its 52nd (!!) year….and to spend time with these friends and colleagues @KJArmache @ShilatifardLab @berger_lab @AdelmanLab , @CreminsLab

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Cigall Kadoch

@CKadoch

3 years

Congratulations to my @foghorntx $FHTX and the $LLY teams on our very exciting new partnership! Looking forward to the years ahead! #cancer #drugs #chromatin

Endpoints News

@endpts

3 years

Eli Lilly's Jake Van Naarden uncorked a deal to provide Flagship-backed Foghorn Therapeutics $380 million — $300 million in cash and $80 million for a premium equity deal — to jump on board the biotech’s development platform.

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Cigall Kadoch

@CKadoch

2 years

Thank you so much, @FASEBorg for this wonderful honor! @kadochlab

FASEB

@FASEBorg

2 years

Join us in congratulating the 2021 Excellence in Science Award recipients: Celeste Simon @PennMedicine , Valentina Greco @YaleMed , and Cigall Kadoch @harvardmed ! Read more:

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Cigall Kadoch

@CKadoch

6 months

Excited to advance our work with Cancer Grand Challenge @CR_UK @CancerGrand as part of Team PROTECT to address major challenges in treating children with cancer. A major signal to the world in London today with not 1 but 2 (!) newly announced teams focused on #pediatric #cancer !

Cancer Grand Challenges

@CancerGrand

6 months

📢 Announcing five new global #CancerGrandChallenges teams! 📢 We're thrilled to announce five new teams, each receiving up to $25m over five years to tackle some of cancer's toughest challenges. Meet the teams: @CR_UK @theNCI

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Cigall Kadoch

@CKadoch

1 year

Exciting new results from our @kadochlab with the Politi lab at Yale highlighting the utility of mSWI/SNF #BAFcomplex ATPase inhibitors in reversing kinase inhibitor #drugresistance in #EGFR -mutant #lung #cancers . Congrats to the team on this timely and impactful study!

Cancer Cell

@Cancer_Cell

1 year

Online Now: Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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Cigall Kadoch

@CKadoch

5 years

Thank you, @DanaFarber for your support of our work in the @kadochlab - a blog detailing our recent paper in @CellCellPress , published last week

Greater Understanding of How Cells Access Their DNA May Aid Treatments | Dana-Farber Cancer...

Published: December 3, 2019Research by the Kadoch Lab (led by Dana-Farber’s Cigall Kadoch, PhD), published in Cell, drills down into the details on how the opening mechanisms fail in Coffin-Siris...

blog.dana-farber.org

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Cigall Kadoch

@CKadoch

4 years

Excited to see this terrific partnership between @foghorntx and @Merck announced today! @endpts ! #drugdiscovery #chromatin #transcription

Endpoints News

@endpts

4 years

Merck dangles up to $425 million to team with Flagship’s Foghorn Therapeutics on drugging the shape of DNA

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Cigall Kadoch

@CKadoch

5 years

Congratulations, @kaelin_lab !!! The most fun to celebrate with you @DanaFarberNews !!

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Cigall Kadoch

@CKadoch

1 year

Exciting new work from our @kadochlab highlighting the outsized contribution of #chromatin remodelers- specifically, the mSWI/SNF ( #BAF ) complexes- in #neurodevelopmental disorders and autism. Check it out! Congrats, @FreddyMValencia , @akshaysci and our collaborators!

Kadoch Lab

@kadochlab

1 year

Congratulations to @FreddyMValencia and @akshaysci on their newest study, just published in @NatureGenet ! Beautiful analysis highlighting that #SWISNF / #BAFcomplex genes are the most frequently perturbed gene classes in #neurodevelopmental disorders.

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Cigall Kadoch

@CKadoch

3 years

Thank you, @broadinstitute and @IndraniMk for profiling our work @kadochlab @DanaFarber ! I am fortunate to work alongside such a talented, creative, kind, and dedicated group of people each day, and am excited about all we have to come! This journey is just beginning.

Broad Institute

@broadinstitute

3 years

A 2013 discovery by @CKadoch linking mutations in a cellular machine called BAF to cancer was the start of a journey for @kadochlab @danafarber . Read about that journey of discovery finding BAF-related disease mechanisms and therapeutic opportunities:

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Cigall Kadoch

@CKadoch

11 months

Excited to see this one out in @CellCellPress ! Congrats to co-first authors @ajinkyapatil00 in our @kadochlab and @DNAmyStrom in @brangwynnelab , along with all collaborators, esp @PappulabWashU and @GygiLab ! We are excited about the broad-spanning implications of this work!

brangwynnelab

@brangwynnelab

11 months

Thrilled that this exciting paper is now out! Really amazing work by @ajinkyapatil00 in @CKadoch lab & @DNAmyStrom in our lab w/ great collaborators including @PappulabWashU . One of the most important papers ever in the biomolecular condensate field!!!

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Cigall Kadoch

@CKadoch

1 year

Excited to be part of this terrific team with @KStegmaier_DFCI @Armstrong_dfci @fischerlab1 and Ben Ebert at @DanaFarber !Thank you for the opportunity, @CancerGrand !

Dana-Farber News

@DanaFarberNews

1 year

Congratulations to @DanaFarber 's Rosalind Segal, Benjamin Ebert, Cigall Kadoch, Eric Fischer, Kimberly Stegmaier and Scott Armstrong on being shortlisted for the next @CancerGrand Challenges awards! (Photo by Ken Richardson Photo) #CancerGrandChallenges

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Cigall Kadoch

@CKadoch

2 years

Such an honor to hood two of my students in the 2022 @harvardmed PhD graduation yesterday evening- first time in-person in 2 years! Congrats, Drs. Hayley Zullow and @dc0mst0ck !! @BBS_Harvard @Harvard_Imm 🎉🎓

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Cigall Kadoch

@CKadoch

5 months

That’s a wrap #AACR24 ! Great science and happy to spend time with many colleagues and friends! @iannisaifantis1 @jdlicht @califano_lab @AbateShenLab @politikaterina @tarumurmur pictured here and many others!

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Cigall Kadoch

@CKadoch

5 months

Thank you, @DanaFarber @DanaFarberInno for the opportunity to give the Keynote at the Inaugural #Accelerator Scientific Symposium this morning! #cancer #cancerresearch #Innovation #drug #discovery @kadochlab

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Cigall Kadoch

@CKadoch

4 years

Thank you, @ASBMB for your support and this nice article!

ASBMB

@ASBMB

4 years

Congratulations to ASBMB member @CKadoch on receiving the 2020 @AACR Award for Outstanding Achievement in Basic Cancer Research, which recognizes achievements in basic research into #cancer by faculty 45 years old or younger.

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Cigall Kadoch

@CKadoch

9 months

Thank you so much for all the support over the years, @DanaFarber which has made this special recognition possible ! @kadochlab @DanaFarberNews

Dana-Farber News

@DanaFarberNews

9 months

(Far left) Cigall Kadoch, PhD, ( @CKadoch ) of @DanaFarber is a recipient of this year’s @MSKCancerCenter Paul Marks Prize for Cancer Research presented biennially to cancer research leaders under 50 who are making significant contributions.

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Cigall Kadoch

@CKadoch

1 month

Exciting to see our @kadochlab and @Oser_Lab collaborative study focused on mSWI/SNF chromatin remodeling complexes in small cell lung cancer out in @Cancer_Cell ! This is one of 4+ studies published/soon to be published highlighting the potential for #BAF disruption in SCLC!

Kadoch Lab

@kadochlab

1 month

Excited to see our collaborative work with @Oser_Lab @DanaFarber @DanaFarberNews on #SCLC #lungcancer out in @Cancer_Cell , identifying chemically targetable #BAFcomplex chromatin regulatory dependencies and providing foundation for new clinical studies for this aggressive cancer.

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Cigall Kadoch

@CKadoch

5 months

Thrilled to watch @Jstlaurent_MD from our @kadochlab and supported by @RsdpScholars present her fantastic new work on mechanistically dissecting and targeting mSWI/SNF #BAF complex remodelers in aggressive endometrial #cancers @AACR #AACR24 #aacr here in San Diego!

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Cigall Kadoch

@CKadoch

7 months

Thank you, @UTSWNews @CRSM_UTSW for a great seminar visit today! Enjoyed presenting our @kadochlab work, seeing so many friends and colleagues as well as connecting with new ones @Transactivator @Mendell_lab @SJMorrison_ @PingMu_PhD , Nobel Laureate Joe Goldstein and others!

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Cigall Kadoch

@CKadoch

3 months

Thank you @nyugrossman for having me today in NYC, and especially to @KJArmache for being an incredible host! A day of great scientific meetings and wonderful to see many colleagues and friends, including @iannisaifantis1 !

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Cigall Kadoch

@CKadoch

2 months

Thank you, @NatRevDrugDisc for the opportunity to discuss new mechanistic insights and small molecule agents targeting chromatin remodeling complexes- was a pleasure working with @AsherMullard on this interview! @kadochlab @foghorntx #cancer #drugdiscovery #chromatin

Nature Reviews Drug Discovery

@NatRevDrugDisc

2 months

Chromatin-targeted drug discovery at “a very special moment” Cigall Kadoch, a researcher at Dana-Farber Cancer Institute & co-founder of Foghorn Therapeutics, discusses the case for a new wave of epigenetic drugs targeting chromatin remodelling complexes

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Cigall Kadoch

@CKadoch

2 months

So lucky to work with these amazing people each day! @kadochlab @DanaFarber @harvardmed

Kadoch Lab

@kadochlab

2 months

@kadochlab happy hour on the beautiful @harvardmed quad this evening! So proud of our amazing team!

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Cigall Kadoch

@CKadoch

5 years

Big day for the @kadochlab graduate students, @mcbride_matthew and Brittany Michel! @harvardmed @HarvardGSAS @Harvard graduation! Congratulations on these amazing Ph.D.s!

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Cigall Kadoch

@CKadoch

4 years

Presentation of our work in developing a novel SS18-SSX fusion- specific antibody! Collaboration between @mcbride_matthew of @kadochlab , Esther Baranov and Jason Hornick of BWH @BrighamWomens , and @CellSignal ! Congrats to all— Publication coming....

Cell Signaling Technology

@CellSignal

4 years

Don’t miss Dr. Baranov of @brighamwomens Dept of Pathology speaking at #USCAP2020 Mar 2 @ 11am on A Novel SS18-SSX Fusion-Specific Antibody for the Diagnosis of Synovial Sarcoma. #antibody

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Cigall Kadoch

@CKadoch

1 year

Exciting new findings from our @kadochlab @DanaFarber @harvardmed @HHMINEWS regarding the role for #chromatin remodelers in viral infection! This was a terrific collaboration with the @WilenLab @YaleMed ! Congrats, @ajinkyapatil00 and @JinWei0911 on this beautiful work!

Nature Genetics

@NatureGenet

1 year

🎆 ONLINE TODAY @NatureGenet 📰 Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection 👫 @WilenLab @CKadoch @kadochlab @JinWei0911 @ajinkyapatil00 and team 👇🏻

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Cigall Kadoch

@CKadoch

5 years

Thank you so much, @LGlimcherMD for this and for all of your support- means a great deal to me! @DanaFarber @DanaFarberNews

Laurie Glimcher MD

@LGlimcherMD

5 years

Congratulations to Cigall Kadoch for winning the Wachtel Cancer Research Award for her work in chromatin regulation.

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Cigall Kadoch

@CKadoch

5 years

Thank you so much, @ScienceTM @aaas @NCIResearchCtr ! And congrats to all members of the @kadochlab as it is their wonderful collective work that I had the privilege to present today!

Science Translational Medicine

@ScienceTM

5 years

Cigall Kadoch has won the 2019 AAAS Martin and Rose Wachtel Cancer Research Award for her innovative work revealing how mutations in #chromatin remodeling machines drive rare forms of cancer. Congratulations! @CKadoch

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Cigall Kadoch

@CKadoch

2 years

A true honor to participate in this terrific event with @FlagshipPioneer this evening to share a bit about the story of @foghorntx and @kadochlab @DanaFarber @harvardmed !

Flagship Pioneering

@FlagshipPioneer

2 years

As Flagship celebrates International Day of Women and Girls in Science, @CKadoch , a founder of @foghorntx and Associate Professor of Pediatric Oncology @DanaFarber and @harvardmed , joins Flagship’s @ChristineHeenan to share more about her dynamic career. #IDWGS

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Cigall Kadoch

@CKadoch

20 days

It was a huge privilege to address the @PanMass Challenge crowd last night in #Sturbridge ! Thank you to the riders, volunteers, sponsors, donors and all those involved for the tireless efforts on behalf of cancer patients! @DanaFarber @DanaFarberNews @LisaWBZ @wbz

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Cigall Kadoch

@CKadoch

1 year

Thank you, @FlagshipPioneer !

Flagship Pioneering

@FlagshipPioneer

1 year

Congrats to Cigall Kadoch, co-founder of @foghorntx , on being named a finalist for the 2023 Blavatnik National Awards in the life sciences. Tune in to a chat from Flagship’s 2023 Women in Science event to hear more from Cigall about her career:

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Cigall Kadoch

@CKadoch

7 months

Very happy for this fantastic progress by @foghorntx in collaboration with @LoxoLillyOnc @EliLillyandCo ! First stop for this agent: BRG1/ SMARCA4-mutant non-small cell lung cancer ( #NSCLC ).

Foghorn Therapeutics

@foghorntx

7 months

We're pleased to announce that our BRM selective inhibitor, in partnership with Lilly, is moving into the clinic. Learn more about the news and our primary development plans to target BRG1 mutated non-small cell lung #cancer (NSCLC):

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Cigall Kadoch

@CKadoch

1 year

Thank you, @MayoClinic for the wonderful honor to give the Rusnak Memorial Lecture and for a terrific visit!

Veronica Rodriguez-Bravo

@VRodriguezBravo

1 year

We enjoyed today the fantastic research presented by @CKadoch @kadochlab @DanaFarber sharing their latest on chromatin remodeling complexes deregulation in human disease. So Inspiring! Thank you for visiting and delivering this lectureship @MayoClinic

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Cigall Kadoch

@CKadoch

1 year

Great to catch up with so many friends and colleagues @AACR #AACR23 @Armstrong_dfci @jdlicht @nes047 @NimerLab @DrSDNimer @ElizSMcKenna and many others!

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Cigall Kadoch

@CKadoch

6 months

A better-late-than-never post of @KeystoneSymp #KSCancerEpi24 in Santa Fe last week! Great to see everyone and discuss new advances in #epigenetics #cancer #generegulation #chromatin .

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Cigall Kadoch

@CKadoch

2 years

Congrats to Hayley in our lab on her beautiful PhD thesis work, published today in @MolecularCell @CellPressNews ! @BBS_Harvard @harvardmed @HarvardMITmdphd @DanaFarberNews @broadinstitute

Kadoch Lab

@kadochlab

2 years

Congrats to Hayley Zullow of @kadochlab @HarvardMITmdphd @bbs_harvard programs and our team, including @akshaysci , @junqilab , @ar_davino , and many others, on this exciting new study out today in @MolecularCell @CellPressNews ! Tweetorial below: (1/7)

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Cigall Kadoch

@CKadoch

6 months

Thank you, @ColumbiaPS @ColumbiaMed for hosting me for the Institute for Cancer Genomics Seminar Series today in NYC! Great time seeing many friends and collaborators! #ricardodalla -favera, #barryhonig @LuLaboratory @cohesinlab @TheOncoOptimist @califano_lab and many others!

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Cigall Kadoch

@CKadoch

4 years

Thank you, @DanaFarberNews for featuring our @kadochlab new work on #synovial #sarcoma and mSWI/SNF (BAF) #chromatin remodeling complexes- exciting progress in our mechanistic understanding of this highly aggressive cancer type.

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Cigall Kadoch

@CKadoch

4 months

So happy for our outstanding graduate student, @whit_lieberman who has been awarded the NIH F31 fellowship to support her new work on chromatin remodelers in the lab! An honor to watch your success and excited for all that you will accomplish, Whitney! @NIH @chemical_phd

Kadoch Lab

@kadochlab

4 months

Congratulations to @whit_lieberman in our lab who had just been officially awarded an NIH F31 fellowship to support her exciting graduate studies! We are thrilled!! @kadochlab @chemical_phd

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Cigall Kadoch

@CKadoch

6 months

Day 1 of @TDCowen @TDCowenResearch 44th Annual #Healthcare Conference in #Boston and great night at @tdgarden @celtics court shooting hoops! 🩺🧬🏀Jeff Solomon, you are the king of fun events!! @foghorntx well represented on court and w/great presentation from our CMO!

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Cigall Kadoch

@CKadoch

21 days

Thank you @Honda and Team Honda @bostonmarathon members for visiting us in the @kadochlab and for all you do to bring support to @DanaFarber @DanaFarberNews #cancer #research ! Onward!!

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Cigall Kadoch

@CKadoch

5 years

Congrats to @joshbiology , Zach, @ar_davino and other @kadochlab members on this exciting new paper in @NatureGenet focused on the ATPase module of mSWI/SNF complexes! Great work, all!

Nature Genetics

@NatureGenet

5 years

The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity–independent genomic targeting (Pan et al.)

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Cigall Kadoch

@CKadoch

6 years

Great chromatin conference in Spetses, Greece last week- fantastic talks and dinners with students, thanks to A. Ladurner and @MarcusBuschbeck @ChroMeITN !! @kadochlab attendance next time!

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Cigall Kadoch

@CKadoch

3 years

Thanks, @BiotechCH @bradloncar @daphnezohar @cngarabedian for having me! Was fun discussing our @kadochlab ‘s research in the area of chromatin and gene regulation, the history of @foghorntx , and the exciting news of the week re: our partnership with @LillyPad @loxooncology !

Aaron Dy, PhD 👨🏻‍🔬🏃🏻‍♂️

@AaronJDy

3 years

Great hearing from @DanaFarber ’s own @CKadoch tell @BiotechCH about chromatin regulation’s major role in cancer, her work leading to co-founding @foghorntx , and the startup’s exciting new partnership with Lilly’s @loxooncology

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Cigall Kadoch

@CKadoch

1 year

It was terrific to participate in the @NIH RADAR Workshop on Biomolecular Condensates these past two days. Great to see these good friends and colleagues as well as to meet many new investigators.

brangwynnelab

@brangwynnelab

1 year

Great discussion meeting ⁦ @NIH ⁩ w awesome scientists and friends including ⁦ @PappulabWashU ⁩ ⁦ @CKadoch ⁩ Phil Sharp ⁦ @mitchguttman ⁩ ⁦ @youngricka ⁩ and others

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Cigall Kadoch

@CKadoch

3 months

Very special to participate in the @MPI_MolGen @maxplanckpress 60th Anniversary Symposium in Berlin this week and great to see many colleagues and friends! @dhnisz and Alex Meissner, @MarsonLab @morris_lab @HymanLab @AsifaAkhtar1 and many others!

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Cigall Kadoch

@CKadoch

3 months

Congratulations, Dr. @ajinkyapatil00 on your official graduation from @harvardmed and an honor to hood you and meet your family!! So many amazing achievements in your PhD! And thrilled to watch past @kadochlab member Dr. @JohnPulice also walk across the stage! Congratulations!!!

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Cigall Kadoch

@CKadoch

2 years

Congratulations to @kadochlab members @proodolph , Clayton Collings, and our many collaborators on this exciting new study focused on the mechanism of an aggressive #meningioma subtype! #cancer #BAFcomplex #chromatin #ncBAF #BRD9

Kadoch Lab

@kadochlab

2 years

Congrats to @proodolph , Clayton Collings and all co-authors on this recent publication in @NatureGenet ! #cBAF compromise via SMARCE1 loss in clear cell #meningioma (CCM) -->increased assembly and function of #ncBAF complexes, leading to CCM-specific oncogenic gene expression.1/2

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Cigall Kadoch

@CKadoch

1 year

Congrats to @ajinkyapatil00 from my @kadochlab @DanaFarber @harvardmed @HHMINEWS and @JinWei0911 from the @WilenLab @YaleMed on this exciting new study! #chromatin #viruses #sarscov2 #COVID19 #BAFcomplex #inhibition

Dana-Farber

@DanaFarber

1 year

Researcher @Ckadoch finds that a new class of oral drugs can inhibit a wide range of SARS-CoV-2 variants. 💻

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Cigall Kadoch

@CKadoch

6 years

Congrats, @joshbiology and team in the @kadochlab @broadinstitute @DanaFarber on an exciting paper in @CellSystemsCP !

Broad Institute

@broadinstitute

6 years

Cancer gene dependency maps help reveal proteins' relationships

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Cigall Kadoch

@CKadoch

7 months

Thank you, @foghorntx for the opportunity to share a bit about our science and the biology behind new #medicines being developed at Foghorn!

Foghorn Therapeutics

@foghorntx

7 months

Do you know how Foghorn Therapeutics was founded? Dive into the visionary journey of our company with our founder, @CKadoch , and hear her story behind the inception of Foghorn and the groundbreaking science to modulate the chromatin regulatory system:

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Cigall Kadoch

@CKadoch

1 year

Thank you @LGlimcherMD @DanaFarber @DanaFarberNews for all of your continued support!

Laurie Glimcher MD

@LGlimcherMD

1 year

A new study co-led by @CKadoch shows that her years of work exploring mSWI/SNF complexes that led to experimental cancer therapies also show promising use against COVID-19 by inhibiting a wide range of COVID variants.

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Cigall Kadoch

@CKadoch

6 years

Congratulations, @joshbiology on your amazing thesis defense today! The whole @kadochlab @harvardmed is so proud of you and can’t wait to see your exciting studies in print soon!!

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Cigall Kadoch

@CKadoch

4 years

A very exciting morning @foghorntx @Nasdaq !!

Nasdaq Exchange

@NasdaqExchange

4 years

🔔 It's a Foghorn Therapeutics ( @Foghorntx ) takeover in Times Square! This morning, the @Foghorntx team joined us at @Nasdaq MarketSite to celebrate #FoghornTxIPO —and ring the opening bell. Congratulations to all involved. #NasdaqListed $FHTX

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Cigall Kadoch

@CKadoch

5 months

Thank you, @Ludwig_Cancer for your support! @harvardmed @DanaFarber @kadochlab

Ludwig Cancer

@Ludwig_Cancer

5 months

Ludwig @Harvardmed ’s @CKadoch chaired a symposium and presented her lab’s latest findings at #AACR24 on the role of chromatin remodeling complexes in cancer maintenance and drug resistance and the latest on targeting of these protein machines for cancer therapy.

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Cigall Kadoch

@CKadoch

3 years

Thank you so much, @LGlimcherMD @DanaFarber @DanaFarberNews for the support and kind words! We look forward to all that is to come for the @kadochlab , greatly enabled by this new @HHMINEWS support!!

Laurie Glimcher MD

@LGlimcherMD

3 years

Congratulations to Dr. Cigall Kadoch ( @CKadoch ) on being named a @HHMINEWS Investigator, one of the most prestigious honors in science. This support will enable @kadochlab to continue its quest for discoveries in cancer research.

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Cigall Kadoch

@CKadoch

1 year

Next up at @AACR #AACR23 is @ajinkyapatil00 from @kadochlab @harvardmed #AACR Scholar-in-Training award winner presenting his exciting new work on #mSWISNF #BAF complexes! #chromatin #cancer

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Cigall Kadoch

@CKadoch

6 years

A big congratulations to @joshbiology on your graduation!!! I am so honored to have had you as my first Ph.D. student and humbled to have this opportunity to hood you! So many wonderful things you will do in your life!! @harvardmed @kadochlab

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Cigall Kadoch

@CKadoch

3 years

Congratulations on an incredible thesis defense, Hayley! Your @kadochlab mates and I are all so proud of you amd excited to celebrate!

The Harvard/MIT MD-PhD Program

@HarvardMITmdphd

3 years

Congratulations to @HarvardMITmdphd student Hayley Zullow and mentor @CKadoch @kadochlab for a successful @BBS_Harvard thesis defense, entitled “Dysregulation of mSWI/SNF (BAF) Complexes in Human Malignancy.”

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Cigall Kadoch

@CKadoch

1 year

Thank you @harvardmed for this nice feature of our work out today in @NatureGenet - a terrific collaboration with the @WilenLab @YaleMed ! @ajinkyapatil00 @kadochlab @DanaFarberNews @HHMINEWS @JinWei0911

Toward New Antiviral Drugs

New discovery suggests that an emerging class of small-molecule drugs may be used to disable this mechanism and make cells impervious to certain viruses

hms.harvard.edu

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Cigall Kadoch

@CKadoch

3 months

Thank you, @UCDavisHealth @UCD_Cancer for the honor to give the Distinguished Lecture in Cancer Research yesterday! Great to see the tremendous growth of the institution over the past several years! Thank you for hosting, @RLRandallMD , and great to see you, @PrimoLaraMD

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Cigall Kadoch

@CKadoch

1 year

An honor to hood @kristin_qian in today’s @BBS_Harvard @harvardmed doctoral hooding ceremony just a few weeks after her beautiful thesis defense! Congratulations, Dr. Kristin Qian! @kadochlab

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Cigall Kadoch

@CKadoch

4 years

Thank you @theNCI @NCICancerBio #cancer #moonshot #cancermoonshot for this wonderful opportunity! Excited to present some recent @kadochlab studies focused on #synovialsarcoma .

NCI Division of Cancer Biology

@NCICancerBio

4 years

On Sept. 24th at 12:00 pm ET, @CKadoch @DanaFarber will share her #FusOnC2 research focusing on the structure and function of SWI/SNF complexes in synovial sarcoma at the #CancerMoonshot Seminar Series. Learn more:

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Cigall Kadoch

@CKadoch

2 years

Extremely excited for all the key milestones and beyond at Foghorn Therapeutics @foghorntx in 2023– We will continue to take leaps toward our goal of helping millions of patients fighting devastating diagnoses of cancer and other diseases. #cancer #chromatin #drug #discovery #JPM23

Foghorn Therapeutics

@foghorntx

2 years

During #JPM23 , our CEO Adrian Gottschalk shared why he’s excited for 2023 with @FlagshipPioneer , highlighting our upcoming milestones & the prolific nature of our platform to target the chromatin regulatory system to develop precision therapies in oncology & beyond. #FlagshipJPM

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Cigall Kadoch

@CKadoch

6 years

Congrats, @kadochlab on a terrific cover and paper in @Cancer_Cell !!

Cancer Cell

@Cancer_Cell

6 years

Check out the June issue of Cancer Cell

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Cigall Kadoch

@CKadoch

3 years

Thank you, @epicypher colleagues! We at @foghorntx are very excited about this important milestone.

EpiCypher, Inc.

@epicypher

3 years

Exciting news! @foghorntx announced the start of their first human clinical trial, testing their novel BRG1/BRM inhibitor as a treatment for metastatic uveal melanoma (and AML). Congratulations @CKadoch and colleagues!

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Cigall Kadoch

@CKadoch

6 years

Congrats, @joshbiology @_robin_meyers_ in @kadochlab on your article making the cover of @CellSystemsCP ! Made with real data as a tribute to the Joy Division album cover...

Tom Ellis

@ProfTomEllis

6 years

Joy Division inspired cover for @CellSystemsCP this month

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Cigall Kadoch

@CKadoch

6 years

Thank you, @DanaFarber @BostonChildrens for this news piece - @kadochlab is looking forward to our partnership with @BidenCancer Moonshot !

Dana-Farber/Boston Children's

@DFBC_PedCare

6 years

Researchers from @DanaFarber / @BostonChildrens were awarded two national grants from the Beau @BidenCancer Moonshot program. Learn more: #EwingSarcoma #CancerFIERCE

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Cigall Kadoch

@CKadoch

9 months

Thank you @MolecularCell for this terrific #Spotlight piece written about our new work published last month in @CellCellPress @CellPressNews ! Congrats again to @ajinkyapatil00 @DNAmyStrom @brangwynnelab @PappulabWashU @kadochlab and all coauthors!

Molecular Cell

@MolecularCell

10 months

Disordered protein regions partner up the cBAF remodeler for a chromatin dance

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Cigall Kadoch

@CKadoch

4 months

Thank you for having me speak about our @kadochlab work at the Stem Cell Symposium at the @UWISCRM this afternoon! Great to be in Seattle for the day!

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Cigall Kadoch

@CKadoch

11 months

Some coverage of our new @kadochlab work dissecting IDR sequences and their roles in BAF chromatin remodeling condensation and interactions with the @brangwynnelab and @PappulabWashU in @CellCellPress from @Princeton Engineering:

Overlooked parts of proteins revealed as critical to fundamental functions of life

Researchers have uncovered how a key aspect of cell biology is controlled by proteins' intrinsically disordered regions, or IDRs. Their study reveals that IDRs have specific and important interacti...

www.eurekalert.org

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Cigall Kadoch

@CKadoch

7 months

Congrats to Kevin and Alex from our @kadochlab on this new work with the @oser_lab @DanaFarber revealing a critical role for mSWI/SNF #chromatin remodeling complexes in #SCLC ! The uncovered functions open new therapeutic opportunities for this aggressive class of #cancers .

Kadoch Lab

@kadochlab

7 months

Congrats to @BBS_Harvard graduate student Kevin So and computational biologist Alex Ying from the lab on their collaborative work on SCLC with the @Oser_Lab , now posted as a pre-print on @biorxivpreprint !

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Cigall Kadoch

@CKadoch

11 months

Was great speaking at the @BostonDOT #BostonDOT23 yesterday! #chromatin #drugdiscovery #epigenetics #transcriptionfactors #cancer

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Cigall Kadoch

@CKadoch

4 years

Excited to see this published - congratulations, @mcbride_matthew , Nazar Mashtalir, @kadochlab and our colleagues and collaborators! A big step forward in understanding human #synovial #sarcoma . @NatureSMB @DanaFarber @broadinstitute

Kadoch Lab

@kadochlab

4 years

(1/9) Congratulations to @mcbride_matthew and Nazar Mashtalir on their new paper, online today in @NatureSMB ! Especially grateful to our @Muirlab @ongnghiem collaborators. Also Evan Winter, Martin Filipovski, @ar_davino , @proodolph , @FreddyMValencia ,

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Cigall Kadoch

@CKadoch

4 years

Great write up, @kristin_qian ! And great pictures of @kadochlab folks!

Landry Cancer Biology Consortium

@LandryCancerBio

4 years

The Kadoch Lab studies the role of ATP-dependent chromatin remodeling complexes in gene regulation and disease. Our favorite remodeler is the BAF complex—what’s yours? 3/n

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Cigall Kadoch

@CKadoch

1 year

Wonderful collaboration and here’s to many more, @iannisaifantis1 ! Very happy to see this body of joint work between our labs at @DanaFarber and @nyulangone out today in @MolecularCell !

Iannis Aifantis

@iannisaifantis1

1 year

Proud to present a 2nd #AifantisLab 2023 contribution, an beautiful collaboration with @kadochlab spearheaded by @Elena__Batti from our side. The work demonstrates a central role for mSWI/SNF in the coordination of T cell activation and exhaustion...(1/5)

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Cigall Kadoch

@CKadoch

5 years

Congrats again, @FreddyMValencia and thanks to @HarvardGSAS @chemical_phd for featuring us and our work! @kadochlab