Nature - Heterotypic multicomponent interactions are shown to dominate the liquid–liquid phase separation that enables the formation of intracellular condensates.

Philip Ball investigates how cells use condensed 'blobs' to collect the molecules involved in regulating genes

Two faculty members, Clifford P. Brangwynne and Rodney D. Priestley, have each been promoted to professor of chemical and biological engineering.

DNA strands are programmed to assemble into synthetic condensates that can speed up molecular computation.

Structural organization of the genome into transcriptionally active euchromatin and silenced heterochromatin is essential for eukaryotic cell function. Heterochromatin is a more compact form of...

Inside cells, droplets of biomolecules called condensates merge, divide and dissolve. Their dance may regulate vital processes.

The nucleolus is a prominent nuclear condensate that plays a central role in ribosome biogenesis by facilitating the transcription and processing o...

A hallmark of biomolecular condensates formed via liquid-liquid phase separation is the dynamic exchange of condensate components with the surroundings. Such material exchange can be key to condens...

The School of Engineering and Applied Science at Princeton University invites applications for new faculty positions in the area of Bioengineering, at

“Cliff Brangwynne has illuminated some of the most basic principles of life’s machinery,” said Princeton University President Christopher L. Eisgruber.

Nature Methods - Phase separation creates complex condensates in eukaryotic cells. To study these mysterious droplets, many disciplines come together.

The Howard Hughes Medical Institute has awarded Clifford Brangwynne a Transformative Technology Award to create a shared research facility for ultra-high-resolution microscopy, NanoCIE: Nanoscale...

Liquid-liquid phase separation is thought to underly gene transcription, through the condensation of the large-scale nucleolus, or in smaller assemblies known as transcriptional hubs or condensates....

Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane fusion events caused by the same machinery that underlies viral entry. These syncytia are thought to facilitate...

Intracellular bodies such as nucleoli, Cajal bodies, and various signaling assemblies, represent membraneless organelles, or condensates, that form via liquid-liquid phase separation (LLPS)[1][1],[...

WOODS HOLE, Mass.

Liquid–liquid phase separation (LLPS) is widely utilized by the cell to organize and regulate various biochemical processes. Although the LLPS of proteins is kn

Called condensates, the droplets pull together proteins and RNA when and where they’re needed. Now, they’re on pharma’s radar

A high-throughput microscopy screen for drugs that modulate SARS-CoV-2 spike-mediated membrane fusion identifies an essential role for cholesterol in both virus entry and syncytia formation.