Abdel-Wahab Lab @AbdelWahablab Twitter profile

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Abdel-Wahab Lab

2 years

It is a pleasure to announce our publication in @NEJM discovering resistance to non-covalent BTK inhibitors in patients with CLL. A collaborative effort with @anthonymatomd and @TaylorJ_MD led by @ewang2323 , Xiaoli Mi, and @MCThompsonMD .

Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors | NEJM

Covalent (irreversible) Bruton’s tyrosine kinase (BTK) inhibitors have transformed the treatment of multiple B-cell cancers, especially chronic lymphocytic leukemia (CLL). However, resistance can a...

www.nejm.org

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Abdel-Wahab Lab

@AbdelWahablab

2 years

I am excited to announce a new collaborative publication with @bradleybio In @NatureBiotech describing a new technology to harness aberrant RNA splicing for therapeutic intent. Work co-led by @khrystyna_north and @SBenbarche

Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells

Nature Biotechnology - Synthetic introns tailored for specific splice-factor mutations enable targeted cancer gene therapy.

www.nature.com

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Excited to share our new story in @nature on coordinated effects of alterations in RNA splicing and the epigenome in AML patients!

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Abdel-Wahab Lab

@AbdelWahablab

3 years

We are excited to announce our paper in @NatureGenet uncovering a role for minor introns in clonal hematopoietic disorders, Noonan Syndrome, and a diverse number of cancers. A collaboration between our lab ( @sloan_kettering ) and @bradleybio ( @fredhutch ):

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Abdel-Wahab Lab

@AbdelWahablab

2 years

It is a pleasure to announce a new publication “Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia” out today in @Cancer_Cell : Collaboration between @ewang2323 @jacksonlab and Jose Mario Pineda @jpineda223 @bradleybio .

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Abdel-Wahab Lab

@AbdelWahablab

9 months

Excited to announce our collaboration with Ravetch lab @RockefellerUniv on AML-associated antigens, Fc receptors in AML marrow, and characterization of U5 snRNP200 as an exciting AML immunotherapy target. Out today in @NatureCancer :

Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies...

Nature Cancer - Abdel-Wahab and colleagues perform immunophenotyping of AML cells to identify AML-specific surface antigens and show that the RNA helicase U5 snRNP200 represents a therapeutic...

www.nature.com

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Excited to share our study on genomic analysis of histiocytosis neoplasms in @NatureMedicine . >250 patients from @MSKCC and reference centers in France, Belgium, Spain, (plus histiocytosis patients worldwide via MSK's Make-An-IMPACT):

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms

Nature Medicine - Inhibition of CSF-1R with recurrent activating alterations and other actionable targets identified by genomic sequencing elicits clinical activity in patients with histiocytosis.

www.nature.com

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Abdel-Wahab Lab

@AbdelWahablab

3 years

Excited to share our collaboration w/ @bradleybio demonstrating that pharmacologic modulation of splicing induces immunogenic neoantigens and augments response to checkpoint blockade. Jointly led by @SXLuLab , @ejdeneef , @jdthomaslab . Out today in @Cell :

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

By provoking production of “neoantigens” that are recognized by immune cells, drugs that modulate RNA splicing can enhance cancer immunotherapy.

www.cell.com

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Abdel-Wahab Lab

@AbdelWahablab

2 years

Excited to announce a new paper in @CD_AACR on genetic, biological & therapeutic implications of mutations impacting degradation of RAS proteins in clonal hematopoietic disorders. Led by @_SisiChen and collaboration with @castel_pau and @ColemanLindsley

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Abdel-Wahab Lab

@AbdelWahablab

2 years

I am excited to announce a new publication in @BloodJournal with @DaichiInoue5 and @DelwelRuud identifying a novel, previously unannotated oncogenic proteoform of EVI1 present in 1/3 of patients with EVI1-rearranged acute myeloid leukemia:

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Abdel-Wahab Lab

@AbdelWahablab

6 months

Excited to announce our collaborative paper with @TaylorJ_MD and @Nurix_Tx out today in @ScienceMagazine :

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127

A phase 1 clinical trial of a Bruton’s tyrosine kinase inhibitor that can overcome drug resistance of B cell tumors with BTK mutations.

www.science.org

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Abdel-Wahab Lab

@AbdelWahablab

4 years

Excited to share a new study on patients with myeloid leukemias whose cancers manage to escape epistasis of RNA splicing factor mutations:

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Excited to share a paper in our longstanding collaboration with @bradleybio identifying tumorigenic loss of BRD9 in SF3B1-mutant malignancies out today in @nature . Co-led by @DaichiInoue5 and Guo-Liang "Chewie" Chew with amazing help from @kadochlab .

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Abdel-Wahab Lab

@AbdelWahablab

2 years

@rosslevinemd @MSKCancerCenter Thanks so much for your kind words Ross @rosslevinemd . I’m honored to take on this role and hopefully recruit exciting new faculty to @MSKCancerCenter !

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Abdel-Wahab Lab

@AbdelWahablab

2 years

It is a pleasure to announce a unique workshop on Lineage Plasticity & Cell-of-Origin of Hematologic Malignancies hosted by @CHM_MSKCC & @MSKPathology @MSKCancer Center. October 14, 2022. Registration:

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Abdel-Wahab Lab

@AbdelWahablab

4 years

JCI - Mutant SF3B1 promotes AKT and NF-kB driven mammary tumorigenesis

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Abdel-Wahab Lab

@AbdelWahablab

1 year

@ASH_hematology @theNCI @DrAlexisThompsn @ChildrensPhila @MSKCancerCenter @MDAndersonNews @lab_rezvani @OMRF @WeillCornell @DanaFarber Thanks so much to @ASH_hematology for this incredible honor. Thanks also to my many mentors and collaborators I’ve the years for their support.

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Abdel-Wahab Lab

@AbdelWahablab

3 months

Excited to announce our paper out today in @MolecularCell discovering a novel splicing factor GPATCH8 and its requirement for pathologic splicing activity of mutant SF3B1. With @bradleybio & @Doulatov_lab . Led by @SBenbarche , @jpineda223 , & @GalvisBaquero :

GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies

Mutations in the RNA splicing factor SF3B1 are common in cancer and result in widespread alterations in splicing. Here, Benbarche et al. identify GPATCH8 as a novel splicing factor required for...

www.cell.com

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Abdel-Wahab Lab

@AbdelWahablab

4 years

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Out today in @nature our work on MEK inhibitors for #histiocytosis with @DHymanMD and Eli Diamond @sloan_kettering Congratulations to Ben Durham from our group! #PrecisionMedicine

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Congratulations to Alinoor (Mohamad) Rahman and Adrian Krainer for the new paper out today in @GenesDev on the effect of RNA splicing factor mutations on nonsense mediated RNA decay (NMD). A very elegant study on how altered splicing impacts NMD:

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Excited to share our latest work on altered nuclear export signal recognition as a driver of oncogenesis! Insights from patient data @sloan_kettering translated to pathobiologic mechanisms using mouse models, proteomics, and biochemical approaches.

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Abdel-Wahab Lab

@AbdelWahablab

11 months

The Molecular Pharmacology Program at Sloan Kettering Institute @MSKCancerCenter is hiring new faculty. If your research is related to cancer therapeutics, protein engineering, targeted protein degradation, or gene therapy please apply:

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Abdel-Wahab Lab

@AbdelWahablab

2 years

We are excited to announce again a unique workshop on Lineage Plasticity & Cell-of-Origin of Hematologic Malignancies hosted by @CHM_MSKCC & @MSKPathology @MSKCancer Center. October 14, 2022. Registration:

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Happy to see this collaboration with Ernest Guccione out @Cancer_Cell ! Next step is testing these out in clinical trials. #leusm #leukemia

Cancer Cell

@Cancer_Cell

5 years

Guccione @IcahnMountSinai , Abdel-Wahab @sloan_kettering & co. reveal cancer subsets sensitive to PRMT inhibition, synergism of combined PRMT5 and type I PRMT inhibition, and mechanistic insight into the therapeutic efficacy of PRMT inhibition.

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Abdel-Wahab Lab

@AbdelWahablab

5 years

So honored and pleased to be on the cover @Cancer_Cell with @iannisaifantis1 !

Cancer Cell

@Cancer_Cell

5 years

Current cover & featured: Abdel-Wahab @sloan_kettering , Aifantis @iannisaifantis1 @nyuschoolofmed & co identify RNA-binding proteins with AML-specific roles and illuminate a therapeutic approach targeting RNA-binding proteins required for AML maintenance .

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Abdel-Wahab Lab

@AbdelWahablab

2 years

Announcing again a unique workshop on Lineage Plasticity & Cell-of-Origin of Hematologic Malignancies this Friday October 14, 2022. Hosted by @CHM_MSKCC & @MSKPathology @MSKCancer Center. Registration and updated final agenda below:

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Wonderful news: FDA Grants Breakthrough Therapy Designation to the MEK inhibitor Cobimetinib for Histiocytic Neoplasms. Clinical trial effort led by Dr. Eli Diamond and @DHymanMD

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Happy to have our paper out this week in @NatureMedicine ! We are very excited that this preclinical work has led to a Phase I trial Congratulations to Akihide Yoshimi of @abdelwahablab and Michael Seiler of @h3biomedicine and all our co-authors! #Leuksm

Nature Medicine

@NatureMedicine

6 years

The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding spliceosome components:

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Congrats to @scwlee33 and all involved! Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Very happy to see our work on ASXL1 mutant knockin mouse model increasing susceptibility to leukemogenesis published online @JExpMed today! Congratulations to @AbdelWahablab Daichi Inoue! #clonalhematopoiesis #leusm

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Congrats to Joey Pangallo and @bradleybio lab for the new work published in @BloodJournal on rare mutations in RNA splicing factors in blood cancers.

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Abdel-Wahab Lab

@AbdelWahablab

4 years

Thanks so much to @CD_AACR for publishing this and @gouthamnarla for the beautiful editorial! Looking forward to testing new PP2A activating drugs in this context!

Taylor Lab UM

@TaylorJ_MD

4 years

Splice of Life for Cancer: Missplicing of PPP2R5A by Mutant SF3B1 Leads to MYC Stabilization and Tumorigenesis | ⁦ @CD_AACR ⁩ | Great title for editorial about recent ⁦⁦ @AbdelWahablab ⁩ paper ⁦ @sloan_kettering ⁩

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Thanks so much @DamonRunyon for all their support for amazing cancer research, some of it being presented today to honor Bill Raveis!

Damon Runyon Cancer Research Foundation

@DamonRunyon

5 years

Omar Abdel-Wahab, MD, Former Damon Runyon Clinical Investigator, discusses precision oncology, targeting the specific mutations underlying cancer. #braveandbold @sloan_kettering

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Abdel-Wahab Lab

@AbdelWahablab

6 years

#AML Single cell sequencing data from @MDAndersonNews presented by Kiyomi Morita from Koichi Takahashi lab. Validated @AbdelWahablab finding of SRSF2 and EZH2 mutually exclusivity at the single cell level! #ASH18

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Congratulations to @sloan_kettering Leukemia Service Drs. Eytan Stein and Martin Tallman! Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML | NEJM

Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML | NEJM

Mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) occur in 6 to 10% of patients with acute myeloid leukemia (AML). Ivosidenib (AG-120) is an oral, targeted, small-molecule inhibitor ...

www.nejm.org

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Announcing the 2019 @FASEBorg Scientific Research Conference Series on Hematologic Malignancies in Snowmass, Colorado! I am thrilled to be organizing this with Tanja Gruber and excited about our Keynote Speakers, Timothy Ley and Klaus Rajewsky!

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Great to share our recent work with @bradleybio at Splicing Factor Mutations and RNA Biology in Cancer workshop @YaleCancer

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Our latest research article using comprehensive genomic profiling on 643 patients with CLL shows lots of useful information can be gained! Great international collaboration with @ThorstenZenz and Arnon Kater. #CLL #cllsm #leusm

Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia

Leukemia - Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia

www.nature.com

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Abdel-Wahab Lab

@AbdelWahablab

7 years

Hematology 7th Edition textbook out now! Great stuff-happy to contribute our small part.

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Abdel-Wahab Lab

@AbdelWahablab

5 years

3 years has flown by. Lots learned and shared on #medtwitter and #sciencetwitter . Reached >1,000 followers and hope to double in next year. Thanks all for the great community of ideas and data! #MyTwitterAnniversary #Twitterversary

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Thank you @DeptofDefense @CDMRP for funding A Novel Therapy for Targeting Acquired Bone Marrow Failure Diseases

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Excited to hear from Dr. Marina Konopleva @LeukemiaMDA @MDAndersonNews as she shares her work on BCL2 inhibition in #AML @sloan_kettering Hem/Onc Grand Rounds

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Congrats to Kristian Helin @helin_kristian and his lab on the beautiful new study out in @NatureSMB on PRMT5 inhibition, its links to SRSF1 post-translational modifications, and impact of PRMT inhibition on splicing in leukemia.

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

Nature Structural & Molecular Biology - The arginine methyltransferase PRMT5 modifies the splicing regulator SRSF1 and affects acute myeloid leukemia cell survival by modulating SRSF1 function.

www.nature.com

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Thanks so much to @guru_tri , Lingbo Zhang, and @CSHL for this collaboration to identify new druggable regulators of erythropoiesis! Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Thanks @jclinicalinvest , lead author Justin Taylor ( @abdelwahablab ), co-last Jae Park @sloankettering and all co-authors! - Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies #leusm

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Thanks to @iannisaifantis1 lab for the great collaboration! #leukemia #leusm

Cancer Cell

@Cancer_Cell

5 years

Abdel-Wahab @sloan_kettering , Aifantis @iannisaifantis1 @nyuschoolofmed & co. identify RNA-binding proteins with AML-specific roles and illuminate a therapeutic approach targeting RNA-binding proteins required for AML maintenance.

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Abdel-Wahab Lab

@AbdelWahablab

7 years

Clonal hematopoiesis clinic now open @sloan_kettering #PrecisionMedicine in #Cancer prevention/screening #leuksm

Memorial Sloan Kettering Cancer Center

@MSKCancerCenter

7 years

MSK opens first of its kind new clinic to monitor people with a genetic risk for developing #BloodCancer . #ClonalHematopoiesis

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Two years on Twitter went fast! Thanks to the >450 followers that like and retweet our lab. Although meager compared to the Twitter greats, our goal for year 3 is to increase discussion on #leusm and #Leukemia to drive forward collaboration and advances. #MyTwitterAnniversary

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Abdel-Wahab Lab

@AbdelWahablab

4 years

Scientists: Support for the innovation engine of American science: immigrants - Sign the Petition! via @Change

Sign the Petition

Support for the innovation engine of American science: immigrants

www.change.org

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Happy to have @challenlab as @CHM_MSKCC Science in Focus speaker @sloan_kettering #epigenetics #AML #Hematopoiesis

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Congratulations @TaylorJ_MD and @AbdelWahablab contributors! Exciting new work and growing area of interest. Thanks also @BarryTaylorLab and Jose-Antonio Rodriguez for lending their expertise.

Taylor Lab UM

@TaylorJ_MD

5 years

What a nice Monday surprise after long weekend- our paper is out online @CD_AACR ! Altered nuclear export signal recognition as a driver of oncogenesis

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Important breakthrough for AML patients! @sloan_kettering continues to have clinical trials testing Tibsovo in combination with chemotherapy or non-chemotherapy agents to try to get even better results. #leusm

Cancer Cell

@Cancer_Cell

6 years

July 20 @US_FDA approves ivosidenib to treat adult patients with relapsed or refractory acute myeloid leukemia with a demonstrated susceptible IDH1 mutation.

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Congratulations to @sloan_kettering Portlock Challenge winners Dr. Jessica Tao and our own @AbdelWahablab Dr. Justin Taylor!

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Our @AbdelWahablab will miss Lillian Bitner (top left in picture) who is off to do great things after 2 years as technician in our group. Smart, skilled, dedicated and contributed to multiple projects in the lab. We wish her the best!

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Just reached 1,000 followers! Thanks @UqbaKhan for being #1K and all others for supporting #medtwitter #sciencetwitter | Look forward to more tweeting about #leukemia #RNA #splicing #science

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Our manuscript on Trk fusions and Trk inhibition in heme malignancies is in this issue of @jclinicalinvest , free access-check it out! #leusm #leukemia #mmsm #histiocytosis

Journal of Clinical Investigation

@jclinicalinvest

6 years

New issue of The Journal of Clinical Investigation out now: (articles published August 31, 2018)

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Abdel-Wahab Lab

@AbdelWahablab

7 years

Age-associated clonal hematopoiesis mutations in splicing factor mutations differ from other forms of clonal hematopoiesis (chemo, aplastic anemia). Come to plenary session to hear how DNMT3A loss may also affect alternative mRNA splicing.

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Will miss our fantastic summer students, it was great having everyone in the lab!

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Abdel-Wahab Lab

@AbdelWahablab

7 years

Congratulations to Dr. Justin Taylor for nicely presenting his work discovering the functional impact and mechanism of XPO1 hotspot mutations in lymphoid malignancies! #ASH17 Great session with additional talks showing important role of cellular mislocalization in oncogenesis!

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Abdel-Wahab Lab

@AbdelWahablab

6 years

#ASH18 Great job @scwlee33 presenting his new work on Targeting Innate Immune Signaling in Splicing Factor Mutant #MDS #Leukemia

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Great work by Varmus lab we were happy to contribute to! @WeillCornell @sloan_kettering and @fredhutch . Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a...

Mutations affecting the spliceosomal protein U2AF1 are commonly found in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML...

www.pnas.org

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Abdel-Wahab Lab

@AbdelWahablab

7 years

Honored to be able to to take part in the peer review process for @BloodJournal which is integral to maintaining scientific rigor #ASH17

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Abdel-Wahab Lab

@AbdelWahablab

2 years

Please see below an exciting opening for a computational biologist in immunogenomics to work across @sloan_kettering 's @CompOncMSK Computational Oncology Program, @bengrbm lab, and @CHM_MSKCC :

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Abdel-Wahab Lab

@AbdelWahablab

6 years

@AbdelWahablab In-Press Preview @jclinicalinvest JCI - Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies Thanks to @FoundationATCG and @loxooncology and all @sloan_kettering co-authors!

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Congratulations to the others from @sloan_kettering as well! Very inspiring colleagues. I also have to give credit to my incredible lab members and collaborators!

Marc Ladanyi

@MLadanyi

6 years

@clarivate Analytics #HighlyCited2018 Researchers is out. Gratifying to be among 23 from @sloan_kettering on list 👉 incl some on Twitter: @RielyMD @AbdelWahablab @gaojj @rosslevinemd @CharlesSawyers @SohrabShah @MSKCC_Library 👍🍻🍾

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Congratulations to Alessandro Pastore @AbdelWahablab and many thanks to @landau_lab for another great collaboration! #CLL #leukemia #epigenetics

Dan Landau

@landau_lab

5 years

Excited to share our newest work on the study of epigenetic diversification in cancer evolution: With @AbdelWahablab and many friends.

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Impressive work and nice tweetorial @TheDoctorIsVin and colleagues @CellStemCell now out! Great @sloan_kettering collaboration with @job_dekker ! Check it out👇🏽

Aaron Viny

@TheDoctorIsVin

5 years

Very excited to share my work on Stag2, chromatin architecture, and effects on hematopoiesis! Join me in a @MedTweetorials of why this is so important! @CellStemCell

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Just realized this was the 100th Tweet for @AbdelWahablab ! Still new to the Twitterverse and hoping to increase our reach beyond @sloan_kettering . Please retweet! #Leukemia #leusm #Genomics

Abdel-Wahab Lab

@AbdelWahablab

6 years

Genomic precision medicine: on the TRK Highlights exciting research from @cmullighan and our own @abdelwahablab work showing Trk may also be an attractive target in Heme malignancies! #leusm

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Abdel-Wahab Lab

@AbdelWahablab

6 years

#ASH18 Sydney X. Lu from @AbdelWahablab @sloan_kettering presenting splicing factor mutant #AML more sensitive to RBM39 degradation by anti-cancer sulfonamides due to RBM39 effects on splicing. #leukemia

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Great thread @DHymanMD telling the story of how we got here, building on the great work of many others and #teamscience !

David Hyman

@DHymanMD

5 years

New at @nature - Efficacy of MEK inhibition in patients with histiocytosis. The culmination of an amazing 7-year collaboration @sloan_kettering with Eli Diamond @AbdelWahablab @ECDGA @Histiocytosis @Roche and many others! [1/x]

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Thanks @sloan_kettering for highlighting our work on XPO1 hotspot mutations in cancer with @BarryTaylorLab and Jose-Antonio Rodriguez @upvehu ! #lymsm #leusm #PrecisionMedicine

Memorial Sloan Kettering Cancer Center

@MSKCancerCenter

5 years

“Researchers knew that XPO1 regulates which proteins are located in a cell’s nucleus & which get moved to the cytoplasm. But until now, nobody has ever shown how the alteration of the XPO1 protein could cause cancer. This study shows how.” @AbdelWahablab

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Sequencing results from >500 patients on BEAT AML trial now out in @nature #leusm #Leukemia #BeatAML

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Abdel-Wahab Lab

@AbdelWahablab

4 years

Congratulations to Luisa Escobar Hoyos on this work! An excellent collaboration between @AbdelWahablab and Steve Leach @CancerDartmouth and @bradleybio . Lots of help from @LoweLabMSKCC as well. Please take a look at Luisa's new lab at @YaleCancer :

Luisa Escobar-Hoyos, MSc, PhD

Dr. Escobar-Hoyos obtained her master’s degree in Biomedical Sciences at the Universidad del Valle in Cali, Colombia. As a Fulbright Scholar, she pursued a Ph.D

medicine.yale.edu

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Abdel-Wahab Lab

@AbdelWahablab

5 years

@bradleybio @nature @DaichiInoue5 @kadochlab It has been an honor to work with Rob Bradley @bradleybio these last 7 years. I have to thank @DamonRunyon for introducing us and @fredhutch for their beautiful writeup of this work!

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Thanks @NatureRevCancer and @krknrm for the N&Vs covering our work “Altered nuclear export signal recognition as a driver of oncogenesis”

Delivering to the wrong address

Nature Reviews Cancer - Taylor et al. demonstrate a causative role for XPO1 mutations in cancer through changing nuclear export signal recognition.

www.nature.com

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Abdel-Wahab Lab

@AbdelWahablab

5 years

@nature Wonderful collaborative effort with Woody Lin and Adrian Krainer @CSHL as well as @dwiseman78 at @CR_UK and @sloan_kettering investigators.

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Excited for Laura Pasqualucci @sloan_kettering Hem/Onc Grand Rounds: Genetic and Epigenetic Drivers of B-Cell Lymphoma

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23

Abdel-Wahab Lab

@AbdelWahablab

5 years

@NatureMedicine @mskcc This study identifies bona fide activating mutations in CSF1R (the Macrophage colony-stimulating factor 1 receptor), clinical responses to selpercatinib (the RET inhibitor, and surprising results from identical twins with histiocytosis.

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Happy to have had our small part in this. Looking forward to many more great collaborations @landau_lab !

Dan Landau

@landau_lab

5 years

Excited to share our single-cell multi-omics work @nature ! GoT links somatic mutations to single-cell RNAseq with @10xGenomics scale. Congrats @AnnaEnim @thinktank_Q @ChaligneRonan and big thanks to many friends & for @psmibert magic!

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Preprint from @landau_lab that pairs genotyping with scRNA-seq to learn about biology of mutant and non-mutant bone marrow progenitors in MPN. #leusm @sloan_kettering @WeillCornell

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Thanks @LLSResearch for all the support and making these kinds of basic/translational studies possible! #leukemia #leusm

Leukemia & Lymphoma Society Research

@LLSResearch

5 years

Seen in @Cancer_Cell today: We are proud that 6 co-authors are either current or former #LLSCDP : Lee, @Akihide_Yoshimi & Inoue are #LLSSFellow , Tibes & @AbdelWahablab are #LLSSCR , while @iannisaifantis1 was a #LLSScholar and is a current #LLSTRP awardee! @NYULMC @sloan_kettering

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Great talk this early AM by Anna Nam from @landau_lab - developed new technique Single Cell Genotyping of Transcriptomes (GoT) to study disease biology of #MPN @https ://ativsoftware.com/appinfo.php?page=Session&project=ASH18&server=eventpilot.us&id=119236 #ASH18

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Thanks @CD_AACR for highlighting our recent work with @iannisaifantis1 lab!

Cancer Discovery

@CD_AACR

5 years

Research Watch: A network of #RNA binding proteins maintains #splicing and survival in acute myeloid #leukemia @AbdelWahabLab @iannisaifantis1 #ResearchWatch

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Great talk from @rosslevinemd @RossLevineLab @sloan_kettering #ASCI

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Thanks @Cancer_Cell for the opportunity to discuss a number of important studies in this exciting new arena.

Cancer Cell

@Cancer_Cell

6 years

Cancer-specific splicing changes and the potential for splicing-derived neoantigens , discussed by Escobar Hoyos & Abdel-Wahab @sloan_kettering .

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Abdel-Wahab Lab

@AbdelWahablab

7 years

Looking forward to joining co-presenters at the Workshop on Myeloid Development #ASH17 #leusm

ASH

@ASH_hematology

7 years

We have 6 Fri. Scientific Workshops this year & they are open to all #ASH17 attendees

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Splicing-themed papers are taking over this issue of @Cancer_Cell see @abdelwahablab editorial covering: Cancer-Specific Splicing Changes and the Potential for Splicing-Derived Neoantigens

Cancer-Specific Splicing Changes and the Potential for Splicing-Derived Neoantigens

In this issue of Cancer Cell, Kahles et al. perform a comprehensive analysis of RNA splicing across cancer types and identify novel correlations between genetic alterations and splicing in cancer. In...

www.cell.com

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Abdel-Wahab Lab

@AbdelWahablab

6 years

#leukemia arising from #mediastinalgermcell tumor is fortunately a very rare occurrence but that has hindered research into its biology and treatment. MAKE-AN-IMPACT @sloan_kettering has helped to unite physician-scientists and patients with rare cancers.

Barbara Solit, MBA

@BarbaraSolit

6 years

MAKE-AN-IMPACT has helped @sloan_kettering study leukemias that can occur in young men with #mediastinalgermcell tumor. Led by @AbdelWahablab and @DrDarrenFeldman , the research provides for no cost genetic testing for patients anywhere in the world and enrollment is ongoing.

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Clinically useful analysis of a large number of patients and interesting finding of PPM1D mutations in MPNs. One always wonders if sequencing a larger panel of genes could end up finding something unexpected. Kudos! #leusm

NEJM

@NEJM

6 years

Genetic analysis involving 2035 patients with a myeloproliferative disorder identified eight genomic subgroups with distinct clinical phenotypes, risk of leukemic transformation, and event-free survival. Full study:

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Abdel-Wahab Lab

@AbdelWahablab

2 years

We describe a means to develop synthetic RNA sequences which respond uniquely to cells with cancer-associated mutations in the RNA-splicing factor SF3B1. These “synthetic introns” enable genotype-selective gene expression.

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Abdel-Wahab Lab

@AbdelWahablab

9 months

TWEET 7: We are excited about the potential of U5 snRNP200 for AML and aberrant surface localization of RNA binding proteins as an emerging theme for cancer immunotherapy. Please check out an exciting pre-print from Ryan Flynn @raflynn5 on this topic:

RNA binding proteins and glycoRNAs form domains on the cell surface for cell penetrating peptide...

The composition and organization of the cell surface determine how cells interact with their environment. Traditionally, glycosylated transmembrane proteins were thought to be the major constituents...

www.biorxiv.org

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Abdel-Wahab Lab

@AbdelWahablab

3 years

@sloan_kettering @EdwardPEvansFdn The @EdwardPEvansFdn Center will support research from @rosslevinemd , @PapaemmanuilLab , @DaniyanMd , @LoweLabMSKCC , @DavidKnorrMDPhD , @DrMvandenBrink laboratories and others at MSK.

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Abdel-Wahab Lab

@AbdelWahablab

5 years

Excited for the start of the LXXXIV Cold Spring Harbor Symposium on Quantitative Biology: RNA Control & Regulation! #cshlsymp19

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Abdel-Wahab Lab

@AbdelWahablab

3 years

@sloan_kettering @EdwardPEvansFdn Thanks so much to the @EdwardPEvansFdn for all of their support for MDS research at @sloan_kettering and throughout the U.S.!

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Abdel-Wahab Lab

@AbdelWahablab

6 years

Congratulations to Jae Park @jaeparkmsk and Renier Brentjens from @sloan_kettering Leukemia Service for this tremendously exciting work! #leuksm

Memorial Sloan Kettering Cancer Center

@MSKCancerCenter

6 years

ICYMI - Results published in @NEJM from the longest-running clinical trial of CAR T cell therapy for cancer offer key insights into factors affecting the safety and effectiveness of this groundbreaking treatment. #ALL #Immunotherapy