SonjaSchmid @sciSonja Twitter profile | Pikagi

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SonjaSchmid

@sciSonja

1,966

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856

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Assist. Prof. @UniBasel_en 🇨🇭 developing single-molecule techniques to explore the nano-dynamics of proteins&Co.

Basel, Switzerland

https://t.co/VXagR8jEls

Joined September 2017

Don't wanna be here? Send us removal request.

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@sciSonja

SonjaSchmid

7 days

Nano-Dynamics Lab on tour! 🚐😃🙌 Our 1st lab retreat brings us to a unique venue in the Swiss Alpes🏔️: Greatly organized by the group – time for the team, the science & more. 🤩 And what an amazing road-lunch potluck!! 👌👨‍🍳👩‍🍳

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@sciSonja

SonjaSchmid

3 years

Oh, @NatureNano 's November issue is out now! 😊

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@sciSonja

SonjaSchmid

11 months

Thrilled to finally share these news: our #NanoDynamicsLab is moving to Basel, Switzerland🇨🇭 which brings great opportunities to expand our #smFRET and #nanopore work on experimental molecular dynamics. Much looking forward to joining the Chemistry Dept. @UniBasel by Jan 2024!

@UniBasel_en

University of Basel

11 months

The University Council has appointed Professor Heide Elke Viehweger as professor of neuroorthopedics and Professor Janina Grabs as professor of sustainability research. Professor Sonja Schmid will become the new assistant professor of physical chemistry.

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@sciSonja

SonjaSchmid

7 months

Truly honoured to receive the Young Investigator Award from the @BiophysicalSoc Biological Fluorescence Subgroup. Many thanks!🌻 @HScientific Congratulations to @taekjip on his #gregorioweber award.

@NHatzakis

Nikos Hatzakis lab

7 months

Warm congratulations to @taekjip for being awarded the #gregorioweber award and @sciSonja for the young investigator award in the biological fluorescence in #BPS2024

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@sciSonja

SonjaSchmid

2 years

It’s a great pleasure to share our multi-lab comparison study: "A blind benchmark of analysis tools to infer #kinetic rate constants from single-molecule #FRET trajectories"

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@sciSonja

SonjaSchmid

3 years

How accurate are kinetic rate constants inferred from #smFRET trajectories? 12 expert labs joined forces for a first-ever blind study on this: delighted to share with you the results of this community-driven benchmark, a unique effort carried out over the past 3 years. #preprints

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@biorxivpreprint

bioRxiv

@biorxivpreprint

3 years

Inferring kinetic rate constants from single-molecule FRET trajectories - a blind benchmark of kinetic analysis tools #bioRxiv

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@sciSonja

SonjaSchmid

5 months

Happy to share our new & hopefully instructive @MethodsPrimers on #smFRET : the basics, tech., current&future applications. Thanks @taekjip for leading this joint effort with @fei_jingyi #NamKiLee @rubenlgonzalez @Sneha_0027 #SanghunYeou & me. Full paper:

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@sciSonja

SonjaSchmid

2 years

And so this Friday ends with a FIRST for me: first PI-proposal granted. 🥳 We receive #IPM4 seed funding to study bacterial micro-compartments with single-molecule #nanopore tech. Nice intra- @WUR collab: thanks for much support @copa_bio & Servé Kengen! Eager to get started!!💪😃

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@sciSonja

SonjaSchmid

4 years

Hello world! is live! See what we’re up to, and join us if you’re fascinated by things that move at the nanoscale! 👉 We have two funded positions available to study single-protein dynamics using #smFRET & #nanopores . Join us in NL! RT=🙏🙏🙏

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NanoDynamicsLab

Welcome! At the Nano Dynamics Lab, we are fascinated by the molecular dynamics found in biomolecules, and we strive to investigate them experimentally at the single-molecule level using cutting-edge...

www.nanodynamicslab.nl

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@sciSonja

SonjaSchmid

1 year

I'm honoured to receive this year’s Steinhofer Prize @UniFreiburg . Many thanks to the Steinhofer foundation and all involved. 🙏

@HugelLab

Single-Molecule Lab of Thorsten Hugel

1 year

⁦Congratulations to ⁦ @sciSonja ⁩ ! Yesterday she was awarded the Steinhofer Prize for her contributions to our understanding of protein dynamics. Great science - great talk!

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@sciSonja

SonjaSchmid

2 years

WE ARE HIRING: Thanks to recent grant success with @NWONieuws , we are looking for a talented & enthusiastic #Postdoc and #PhDstudent to join our team in The Netherlands! #nanopores #NEOtrap NEO- #FRET #proteins & Co. Have a look: RT = 🙏🙏🙏🌻

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@sciSonja

SonjaSchmid

3 years

Happy to see our #NEOtrap paper now peer-reviewed & published: "Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations." 👇Have a look at Cees’ tweetorial:

Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations

Nature Nanotechnology - A trap, formed by a DNA-origami sphere docked onto a solid-state nanopore, allows the hydrodynamic trapping and label-free observation of single proteins, enabling...

@cees_dekker

cees dekker

3 years

Our latest paper in @NatureNano : We developed a new type of single-molecule trap that can hold and study a single unlabeled protein for very long times. Superb work by @sciSonja (then a postdoc in our #CDlab , now PI at WUR), with @hendrik_dietz lab 1/

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@sciSonja

SonjaSchmid

3 years

New #preprint of the lab: Can #DyeCycling break the photobleaching limit in single-molecule #FRET ? -> Ben & I think: yes! In a proof-of-concept, we describe how repeated dye replacement may revolutionise time-resolved #smFRET . #OnTheShouldersOfGiants 🧵

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@sciSonja

SonjaSchmid

2 years

Happy to share a new #NEOtrap preprint: Using an orientation-locked DNA-origami, we tune the electro-osmotic flow in-situ, to much extend the protein trapping & sensing capacity of the NEOtrap. Work in collab. with @Cees_dekker ’s lab: 🧵->

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@sciSonja

SonjaSchmid

7 months

New year – new labs: Here's the new home of the Biomolecular Nano-dynamics lab @UniBasel_en , Switzerland! (dev mode) We’re open for science (after an intense month) thanks to this wonderful team! A brief intro tour: let's go!🧬🕳️🧪🍳🔬👍

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@sciSonja

SonjaSchmid

4 years

Would have loved to spread the word myself - but hey, now you know already… MANY THANKS for all your kind words and good wishes! 🙏 I am delighted to continue to do the science I enjoy @WUR next year. Stay tuned for lonely proteins & their dynamic relationships!

@cees_dekker

cees dekker

4 years

Sooo nice: Postdoc @sciSonja treated our group with on-the-spot-prepared icecream and drinks, to celebrate the great news that she secured a tenure-track postion at @WUR to start her own lab in half a year! Big congrats - go build and enjoy the #SchmidLab !

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@sciSonja

SonjaSchmid

4 years

Ahhhh, nice! We're FRETting again! 🤩After 3.5 #FRET -free years for me...😃😃 And 🔴🟢🔴🟢 in disco-mode! 🕺💃Love it! Let the fun begin! #newPI joy Thanks to #MattiaFontana and great pre-work by @HohlbeinLab . 👌👌

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@sciSonja

SonjaSchmid

2 years

Happy to share our paper – now peer-reviewed & typeset: "Can #DyeCycling break the photobleaching limit in single-molecule #FRET ?" (Twittorial below)

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@sciSonja

SonjaSchmid

3 years

New #preprint of the lab: Can #DyeCycling break the photobleaching limit in single-molecule #FRET ? -> Ben & I think: yes! In a proof-of-concept, we describe how repeated dye replacement may revolutionise time-resolved #smFRET . #OnTheShouldersOfGiants 🧵

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@sciSonja

SonjaSchmid

10 months

This is how we do it: From Plasmid to Data in Six Steps: Single-Molecule #FRET -Resolved Protein Dynamics. Benjamin & Jannick's detailed protocol is now available in "Single Molecule Analysis" edited by @IddoHeller @Dulin_Lab #ErwinPeterman :

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@sciSonja

SonjaSchmid

3 years

I wrote a personal 'behind-the-paper blogpost' about our #NEOtrap paper👇, with the aim to fight the ‘iceberg effect’ in academic publishing: Maybe unusual. Curious to hear your comments. As a bonus: my original eureka-moment screenshots from #CDlab 🙂.

@NatureNano

Nature Nano

3 years

New content online: Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations

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@sciSonja

SonjaSchmid

1 year

💡New #preprint of the NanoDynamics Lab in collab. with Staals & de Ridder labs @WUR incl. @cvdelannoy , @BNoordijk : #Nanopores reveal the stoichiometry of single oligo-adenylates produced by type III #CRISPR -Cas. Short 🧵.....:

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@biorxivpreprint

bioRxiv

@biorxivpreprint

1 year

Nanopores reveal the stoichiometry of single oligo-adenylates produced by type III CRISPR-Cas #bioRxiv

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@sciSonja

SonjaSchmid

2 years

Aaaand it's a wrap! It was wonderful to bring the #FRET -friends together in this #FRETsatellite meeting of the #MAF2022 . Many thanks to @WilhelmssonLab for soo much local support and @MadCityLabs1 & @PicoQuant for sponsoring.🙏 Look at this dynamic crowd 😃. [ End of spam 😉 ]

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@sciSonja

SonjaSchmid

4 years

Yey, here is our latest #singleProteinDynamics story with @hugelgroup now out @eLife : CONTROLLING PROTEIN FUNCTION BY FINE-TUNING CONFORMATIONAL FLEXIBILITY. A mini thread with an unexpected twist: #Hsp90 #chaperones #smFRET

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@sciSonja

SonjaSchmid

1 year

Yes! Thrilled to continue our #Hsp90 collaboration with @BiophysK , Laura, Ben, and soon two new colleagues! Thank you @NWOFunding ! Prospective #PhD students: stay tuned! #smFRET dynamics, #chaperones & more.

@BiophysK

Kasia Tych

1 year

I'm grateful and excited to be awarded an @NWONieuws M-2 grant with @sciSonja to take Hsp90 research to the next (single-molecule) level!

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@sciSonja

SonjaSchmid

4 years

Out now: our review on #nanopores & their applications to functional=intact #proteins together with @cees_dekker (now peer-reviewed and ‚layouted‘). Enjoy!

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@sciSonja

SonjaSchmid

3 years

Tomorrow, we have the first (MSc) thesis defence at the #NanoDynamicsLab – and I can't help feeling proud although this is really David's achievement. 🙃 (Is this the PI disease kicking in...?)

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@sciSonja

SonjaSchmid

10 months

Kürzlich wurd ich für die Zeitung "Der Rheintaler" zu unserer Forschung & Umzug an die @UniBasel interviewt. "Neugier und Lust am Nachforschen" Text von Journalistin M. von der Linden:

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@sciSonja

SonjaSchmid

4 years

New Year. New job. New profile pic. Still simply me. My best wishes for your 2021! ...with some hopeful tunes for the calm before the storm:

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@sciSonja

SonjaSchmid

5 months

Want to do your #PhD in one of the happiest countries on earth? Wait no more 😃: Two weeks left to apply for a PhD with us, to elucidate #chaperone proteins with new single-molecule approaches #smFRET , #DyeCycling , #unnaturalAA etc.

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@sciSonja

SonjaSchmid

6 months

Plus, we're hiring for our lab @UniBasel_en 🇨🇭: Share the fascination 👇 for direct observations of proteins in action #smFRET #nanopore ? Below are 2 chances to join our team as a #PhD student:

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@sciSonja

SonjaSchmid

2 years

Happy to see @ChenyuWen_Nano 's hand painted cover out now @NanoLetters , illustrating the #NEOtrap 2.0 with nanoscale orientation control achieving in-situ tuned single-molecule trapping by electro-osmosis. In collab with @cees_dekker @TheDNeva @xinshi_d

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@sciSonja

SonjaSchmid

2 years

Nice to hear: our #NEOtrap article is the MOST READ @NanoLetters in the past 30days. Many thanks for your interest! 🙏 more underway... :)

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@sciSonja

SonjaSchmid

6 months

Plus, we're hiring for our lab @UniBasel_en 🇨🇭: Share the fascination 👇 for direct observations of proteins in action #smFRET #nanopore ? Below are 2 chances to join our team as a #PhD student:

@sciSonja

SonjaSchmid

6 months

Interview about our work, interests, advice for young scientists by the Swiss Nanoscience Institute @SNIunibas @UniBasel

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@sciSonja

SonjaSchmid

2 years

Grateful that our Dutch #nanopore collaboration can now take off: exciting research ahead together with @MagliaGiovanni and @cees_dekker ! Thanks to XL funding by @NWO_Science , we’ll soon be hiring a PD&PhD @WUR . #NEOtrap #NEOfret & Co. Stay tuned! Congrats to all awardees!🥂

@NWO_Science

NWO Domain Science (Inactive)

2 years

NWO has approved 21 grant applications in the Open Competition Domain Science-XL programme. The topics vary from studying coronavirus Achilles’ heel to learning about danger through the experiences of others. Congratulations to the awarded applicants!

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@sciSonja

SonjaSchmid

4 years

Dear applicants, - please read the job ad. - please dont list vortexing as your expertise. - please be concise & to the point. Thanks. A newPI not yet numb to all this.

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@sciSonja

SonjaSchmid

5 months

How it started. / How it's going. #TabulaRasa no more... 🤩 Great new #smFRET addition to the lab. 🔴🟢🔴🟢 😊

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@sciSonja

SonjaSchmid

7 months

New year – new labs: Here's the new home of the Biomolecular Nano-dynamics lab @UniBasel_en , Switzerland! (dev mode) We’re open for science (after an intense month) thanks to this wonderful team! A brief intro tour: let's go!🧬🕳️🧪🍳🔬👍

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@sciSonja

SonjaSchmid

11 months

Just dont do this👇: -What does this Belgian PI wanna tell me? -Has a _man_ ever heard this after 3 male profs were appointed across the entire uni? -DM because too shy to go public🤦‍♀️🤦‍♀️🤦‍♀️ Sorry not sorry to be a woman & a prof in science. 'Btw...' so unnecessary 'nonetheless'.

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@sciSonja

SonjaSchmid

3 years

...when the group presents you such #nanopore data on a Friday evening. 🤩🤩🤩 Ah, what a privilege! #newPI joy. Hope I never get used to it. Extra bonus: my old code got new users and still serves us well. :)

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@sciSonja

SonjaSchmid

1 year

Lots of fun doing science & more with these wonderful NanoDynamicsLab people. Time to celebrate 🥳 exciting results, a granted fellowship, a prize, and of course the summer! ...and today, even more good news arrived...😱🤐 Have a great weekend, everyone!🍻

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@sciSonja

SonjaSchmid

2 years

Apply now also online: #PhD & #postdoc positions, fully funded in the Netherlands. Deadline: Oct 31. #nanopores #smFRET #ScienceJobs

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Postdoc in Biophysics

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

@sciSonja

SonjaSchmid

2 years

WE ARE HIRING: Thanks to recent grant success with @NWONieuws , we are looking for a talented & enthusiastic #Postdoc and #PhDstudent to join our team in The Netherlands! #nanopores #NEOtrap NEO- #FRET #proteins & Co. Have a look: RT = 🙏🙏🙏🌻

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@sciSonja

SonjaSchmid

10 months

It's a pleasure to share our recent #Hsp90 review in collab with @BiophysK – right in time for discussions at the @StressCell & @ChaperoneCode meetings in Alexandria (VA): THE KNOWN UNKNOWNS OF THE HSP90 CHAPERONE We discuss 3 fundamental open questions:

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@sciSonja

SonjaSchmid

2 years

Nice to hear: our #NEOtrap article is the MOST READ @NanoLetters in the past 30days. Many thanks for your interest! 🙏 more underway... :)

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@NanoLetters

Nano Letters

2 years

🔓 #OpenAccess + Most Read in the past 30 days: "Orientation-Locked DNA Origami for Stable Trapping of Small Proteins in the Nanopore Electro-Osmotic Trap" by @ChenyuWen_Nano , @TheDNeva , @xinshi_d , @cees_dekker , & @sciSonja

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@sciSonja

SonjaSchmid

3 years

0/4 🧵Very happy to present to you the #NEOtrap ! We shared our progress over time, and here’s now the #preprint plus #tweetorial :

@cees_dekker

cees dekker

3 years

New #CDlab preprint: We developed a new type of single-molecule trap that can hold and study a single unlabelled protein indefinitely in a nanopore. We’re very excited about the potential of this NEOtrap. Superb work by @sciSonja , with @hendrik_dietz lab

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@sciSonja

SonjaSchmid

2 years

Thanks a lot for all the good wishes! I take the occasion to introduce the TEAM (with permission) – a dynamically changing & interdisciplinary group of BSc/MSc/PhD/PD. #Thankful to work & learn with them! ...and have a beer once in a while...😉

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@sciSonja

SonjaSchmid

2 years

And so this Friday ends with a FIRST for me: first PI-proposal granted. 🥳 We receive #IPM4 seed funding to study bacterial micro-compartments with single-molecule #nanopore tech. Nice intra- @WUR collab: thanks for much support @copa_bio & Servé Kengen! Eager to get started!!💪😃

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@sciSonja

SonjaSchmid

3 years

To share with you the many future avenues for the #NEOtrap asap, @cees_dekker & I wrote this perspective: The NEOtrap – en route with a new single-molecule technique @iScience_CP A lot to explore: #NEO - #FRET , nanoparticles, sm-enzymology, un/re-folding...

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@NatureNano

Nature Nano

3 years

New content online: Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations

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@sciSonja

SonjaSchmid

3 years

Glad we could contribute to this @iScience_CP special issue on Single-Molecule Technologies edited by @ChirlminJoo_Lab and @MellerLab : The #NEOtrap – en route with a new single-molecule technique, by @cees_dekker & me. #OpenAccess

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@ChirlminJoo_Lab

Joo_Lab

@ChirlminJoo_Lab

3 years

We are excited to share a special issue in @iScience_CP on the future of single-molecule technologies. You can check it out following this link:

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@sciSonja

SonjaSchmid

1 year

Grateful for the opportunity to share our work in the “cutting edge techniques” session @2023Icbp Seoul along with @George_R_Heath (super-res. HS-AFM), @roybeck (soft matter approaches to IDPs), my previous colleague @JeKyungRyu1 (SMC&HS-AFM). Thanks for the invite to Korea! 🙏

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@sciSonja

SonjaSchmid

3 years

Out now: our perspective on single molecule protein sequencing strategies. #nanopores , MS, fluorescence, conjugation chemistry... – a HUGE team effort led by #JavierAlvaro @ChirlminJoo_Lab @MellerLab . Get inspired! 💥

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@ChirlminJoo_Lab

Joo_Lab

@ChirlminJoo_Lab

3 years

We are very happy to share our collaborative perspective paper on single molecule protein sequencing out today in @naturemethods . A great team effort!

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@sciSonja

SonjaSchmid

1 year

WORK: 13days left to apply for the #postdoc position in my group: label-free single-protein studies using latest #nanopore tech, the #NEOtrap , NEO- #FRET & Co. Get in touch: #FRETfriends welcome! RT = 👌🙏🙏🙏

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@sciSonja

SonjaSchmid

3 years

In more accessible language, @tudelft 's coverage of our #NEOtrap work – a journey to be continued (jointly) @WUR : in English: in het Nederlands:

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@sciSonja

SonjaSchmid

4 years

What can #nanopores do for PROTEIN science? Spoiler: a lot 😃 #labelFree #7ordersInTime ... Please find here our review with @cees_dekker introducing nanopores to everyone interested in proteins, their function & dynamics: Comments welcome!

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@sciSonja

SonjaSchmid

3 years

Happy Holidays to everyone & all the best for your 2022! This forever twinkling 🌟-ry sky was one of the successes we could celebrate in the 1st year of the NanoDynamics Lab. Very happy to work with Ben, David, Raluca & Chenyu, and super eager to share more with you in 2022!🙂

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@sciSonja

SonjaSchmid

1 year

In "An external speed control for nanopore reads", I discuss the recent discovery by @LabRadenovic , Fantner lab, @KeyserLab & coworkers on spatially multiplexed solid-state #nanopores 👇

@NatureNano

Nature Nano

1 year

🤩Latest News & Views @NatureNano by Prof Sonja Schmid @sciSonja "An external speed control for nanopore reads" covers Leitao et al. "Spatially multiplexed single-molecule translocations through a nanopore at controlled speeds"

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SonjaSchmid

3 years

I'll present our #smFRET and #nanopore work later today at Munich's physics colloquium. 👇 Public link below. You're welcome to join if you like.

@LipfertLab

LipfertLab

3 years

Exciting biophysics coming up in the Münchener Physik Kolloquium next Monday at 17:15 - Sonja Schmid from Wageningen

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@sciSonja

SonjaSchmid

6 months

Interview about our work, interests, advice for young scientists by the Swiss Nanoscience Institute @SNIunibas @UniBasel

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Who are the women in nanoscience? Sonja Schmid - Professor at the...

Sonja Schmid studied nanosciences at the University of Basel, left Switzerland for her PhD, and Postdoc and is now back in Basel as an assistant professor of...

www.youtube.com

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@sciSonja

SonjaSchmid

2 years

Great to see @ChenyuWen_Nano 's orientation-locked #NEOtrap 2.0 paper out now in #OA @NanoLetters : See earlier twittorial below. #OpenScience : data on @ZENODO_ORG . Great collab with @cees_dekker @TheDNeva @xinshi_d 👌👌

Orientation-Locked DNA Origami for Stable Trapping of Small Proteins in the Nanopore Electro-Osmo...

Nanopores are versatile single-molecule sensors offering a simple label-free readout with great sensitivity. We recently introduced the nanopore electro-osmotic trap (NEOtrap) which can trap and...

@sciSonja

SonjaSchmid

2 years

Happy to share a new #NEOtrap preprint: Using an orientation-locked DNA-origami, we tune the electro-osmotic flow in-situ, to much extend the protein trapping & sensing capacity of the NEOtrap. Work in collab. with @Cees_dekker ’s lab: 🧵->

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@sciSonja

SonjaSchmid

2 years

Sending you evening greetings from @WUR . @ Team #Helix : did someone else take pics tonight of the beautiful #SaharaSand during dusk? (couldn't capture the full beauty) @copa_bio @SiddhuLab @dolfweijers @RuggeriLab @NicoC_MicSynBio @JorisSprakel @V_Saggiomo @DCSwarts et al?

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@sciSonja

SonjaSchmid

3 years

😱 25nm ø. The Gotthard among regular prot.pores? (33-mer)

@PDBeurope

Protein Data Bank

3 years

This week's #PDB release has 244 new entries, including this cryo-EM structure of Gasdermin-D, a pore-forming protein promoting pyroptosis in response to microbial infection and danger signals (). Find all the new entries at

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@sciSonja

SonjaSchmid

11 months

...when your PhD students want to nominate you for a 'best supervisor' award... 😊🙃🤗 (and this *despite* the move)... 🙏

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@sciSonja

SonjaSchmid

3 years

Great quote by John Jumper @DeepMind during the '50years of the #PDB ' conference #EMBLPDB : "There is no pdb for dynamics." Indeed. So let's change it! 😃 My usual illustration of this issue, to motivate the need for better EXPERIMENTAL techniques to quantify #ProteinDynamics :

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@sciSonja

SonjaSchmid

10 months

A nice example of how scientific debate helps to move fields forward, as it should be:

@cees_dekker

cees dekker

10 months

Background of this paper is interesting as the 4 authors met at a Titisee conference. Given that each of us had a favorite model (scrunching, swing&clamp, hold&feed), we disagreed. But we discussed, ending up with this joint paper on a ‘reel-and-seal’ model that fits most data 2/

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@sciSonja

SonjaSchmid

2 years

Several exciting vacancies for SINGLE-MOLECULE aficionados: for magnetic tweezing @Dulin_Lab : for fluorescence & FRET @seamus_holden : and for nanopore trapping consider our PhD & postdoc openings:

@sciSonja

SonjaSchmid

2 years

WE ARE HIRING: Thanks to recent grant success with @NWONieuws , we are looking for a talented & enthusiastic #Postdoc and #PhDstudent to join our team in The Netherlands! #nanopores #NEOtrap NEO- #FRET #proteins & Co. Have a look: RT = 🙏🙏🙏🌻

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@sciSonja

SonjaSchmid

2 years

Putting final touches on my #MAF2022 talk on #DyeCyling plus on our multi-lab smFRET #kinetics benchmark. Feel free to join: 3:30pm at Palmstedt hall.

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SonjaSchmid

4 years

What a great week for #smFRET .ers! 2 great open-science releases: soft- &hardware: - #deepFRET for automated trajectory analysis by @NHatzakis One to try! - the #smfBox : @CraggsLab 's confocal setup aka. #miCube 's confocal brother🙂

@Craggs_Lab

Tim Craggs - Exciting CEO

4 years

Build your own smfBox - everything you need to build and run accurate and dynamic smFRET experiments - cheaply! #openAccess #openSource #openMicroscopy Paper here: And a great intro video here from the master of microscopy nightmares @DrLachie . Enjoy!

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@sciSonja

SonjaSchmid

5 months

3days left to apply: Fully funded #PhD position on directly observing chaperones in action by #smFRET 👇 RT=🙏

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@sciSonja

SonjaSchmid

6 months

Plus, we're hiring for our lab @UniBasel_en 🇨🇭: Share the fascination 👇 for direct observations of proteins in action #smFRET #nanopore ? Below are 2 chances to join our team as a #PhD student:

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@sciSonja

SonjaSchmid

1 year

Brief thoughts on this👇 MINFLUX vs FRET comparison: #MINFLUX : + a *linear* molecular ruler - but limited by 2D projection-> dynamics? #FRET : + projection independent/orientation tolerant + high throughput + accessible dyes + affordable setups + standardised procedures Comments👍

@Stefan_W_Hell

Stefan W. Hell

1 year

Fretting over #FRET distances 😥? #MINFLUX can be the answer 😃💡! See our paper by S. Sahl et al:

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@sciSonja

SonjaSchmid

3 years

So sweet! Just recorded my #DutchBiophysics talk at @NWONieuws Utrecht, and that's what I got. Thanks!🙏 See you at the online conference with live Q&A on Oct 11/12th:

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@sciSonja

SonjaSchmid

4 years

How it started: How it's going: #NEOtrap 👉 Label-free #nanopore sensing of single proteins.

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@sciSonja

SonjaSchmid

2 years

Wonderful! 👇Warmest congratulations to #BenSchuler @UZH_en on winning the Kazuhiko Kinosita Award. So well deserved! Such deep & elegant works on single-molecule #FRET , #IDP 's & Co. #Inspiring !

@BiophysicalSoc

Biophysical Society

@BiophysicalSoc

2 years

Ben Schuler to Receive the 2023 Kazuhiko Kinosita Award in Single-Molecule Biophysics

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@sciSonja

SonjaSchmid

2 years

So much looking forward to launching the today with the fantastic Jan Lipfert @LipfertLab as our first speaker! This monthly seminar series organized #JasperLandman & me is aimed to bring together the great #fundamental scientists @WUR . #NBPXclub

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@sciSonja

SonjaSchmid

2 years

10 more days to apply: Join us as a #postdoc or #PhDstudent to pioneer the label-free single-molecule detection of protein dynamics using #nanopores , the new NEOtrap, and #FRET .

@sciSonja

SonjaSchmid

2 years

WE ARE HIRING: Thanks to recent grant success with @NWONieuws , we are looking for a talented & enthusiastic #Postdoc and #PhDstudent to join our team in The Netherlands! #nanopores #NEOtrap NEO- #FRET #proteins & Co. Have a look: RT = 🙏🙏🙏🌻

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SonjaSchmid

5 years

Same same but different: solid-state & protein #nanopores side by side. Our review on noise and signal-to-noise is out now:

@cees_dekker

cees dekker

5 years

“Comparing Current Noise in Biological and Solid-State Nanopores” Our latest #CDlab paper out now in @acsnano : We review the types of noise in nanopores and how to optimise signal-to-noise ratio. By @AlessioFragasso and @sciSonja and yours truly.

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SonjaSchmid

10 months

#WORK : Join us for a #PhD in #Chemistry to develop artificial metalloenzymes for sustainable biotech applications and study them with #nanopore technology. PhD in collab. with Dr. Namita Sharma at @WUR 🇳🇱, includes a paid secondment @UniBasel 🇨🇭.

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@sciSonja

SonjaSchmid

3 years

The #SMB2022 was in many ways exceptional: - 1st post-pandemic in-person conf. for many - great science & great views clash with 🇺🇦war close by - my 1st in-person talk with #NanoDynamicsLab results. E.g.: Thanks for the much missed direct discussions! 🙏

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Can DyeCycling break the photobleaching limit in single-molecule FRET?

Biomolecular systems, such as proteins, crucially rely on dynamic processes at the nanoscale. Detecting biomolecular nanodynamics is therefore key to obtaining a mechanistic understanding of the...

www.biorxiv.org

@dsoulias

Dimitris Soulias

3 years

It's the NEOtrap time! @sciSonja #SMB2022

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@sciSonja

SonjaSchmid

2 years

Thanks Mehdi! Great to finally meet the @Hsp90Machine community again! Thanks a lot for having me. 👍

@MedMol

Mehdi Mollapour PhD

2 years

@sciSonja presenting elegant data on Hsp90 dynamic using FRET

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@sciSonja

SonjaSchmid

4 years

Ok let’s try this: CALLING ALL SCIENCE LABS in CH🇨🇭: Go post your lab pics with&without EUcitizens using #Begrenzungsinitiative uf dütsch / #initiativedelimitation en français. Let’s flush away the xenophobia accumulating there. Show them how much CH needs EU! Hospitals pls join!

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@sciSonja

SonjaSchmid

4 years

. @tudelftlibrary -turned- #skiResort and other creative Dutch solutions to the lack of slopes. :)

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@sciSonja

SonjaSchmid

2 years

Come for the #MAF2022 – stay for the FRET satellite meeting! (Program coming asap)

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@WilhelmssonLab

Wilhelmsson Lab

@WilhelmssonLab

2 years

Please help spread the word about a great conference on fluorescence and its applications! Abstract deadline on May 3. Don't miss it if you like fluorescence!

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@sciSonja

SonjaSchmid

11 months

Happy to attend #NWOBiophysics – likely my last – to meet the many wonderful colleagues I got to know over the years in NL. Can't hide: it partly feels like a goodbye tour: Bye NL 🇳🇱, thanks for the wonderful time! Hello CH🇨🇭, looking forward to an exciting future ahead!

@NWONieuws

NWO Nieuws

11 months

NWO Biophysics 2023 is just around the corner, and with a record number of over 500 participants, it looks to be a promising one! Check out all the programme information and final practicalities on the website and see you next Monday!

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@sciSonja

SonjaSchmid

1 year

Don't miss the next NanoBioPhysX Club @WUR with Gijsje Koenderink @gijsjekoenderi1 presenting to us: THE CELL AS A MATERIAL. ⏰Wed 31/05 4pm at Orion 1005. Much looking forward! #NBPXclub

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@sciSonja

SonjaSchmid

2 years

Very happy to be one of the speakers at the #INASCON2022 ! I keep great memories of the 2007(?) version in Fredericia DK that we attended as @SNIunibas nanoscience students. Now looking forward to meeting the new generation at Munich!

@Inascon1

INASCON

2 years

We are hapy to announce @sciSonja from @WUR as a speaker for #inascon2022 !

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@sciSonja

SonjaSchmid

3 years

I'm looking forward to presenting our #NEOtrap for single- #protein studies to the #nanopore community tomorrow (2pm CET). You're welcome to tune in if you like! Zoom link here: Details below👇

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@sciSonja

SonjaSchmid

5 years

Last piece of my PhD work is out: We stimulate protein function in #Hsp90 by reducing conformational flexibility – specifically or NON-specifically. #smFRET reveals how similar steady-states arise from completely different underlying kinetics. Looking forward to your comments!

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@biorxiv_biophys

bioRxiv Biophysics

@biorxiv_biophys

5 years

Same Equilibrium. Different Kinetics. Protein Functional Consequences. #biorxiv_biophys

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@sciSonja

SonjaSchmid

4 years

Thank you @BiophysK ! So many cool female scientists on twitter: you're inspiring! If you like, let's amplify 10 women scientists & keep going. @DinaGrohmann @SabinaCaneva @CPaulino_ @ryhertzberger @_amelie_rocks @Mehrnaz_Mjt @ElwiraSmakowska @Archaellum @NagmaPhD @mycolloids

@BiophysK

Kasia Tych

4 years

Thank you @DorotaKoziej ! So many cool female scientist on twitter, thanks for being visible, you're inspiring! Let's amplify 10 women scientists & keep going. @KamenzLab @sciSonja @alicepyne @DouganGroup @BeatriceRamm @SunjieYe @SalPeyman @SorkinRaya @sas_bakker @ClappertonMegan

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SonjaSchmid

4 years

Would the companies, please, confidentially provide the recipes for their kits & reagents - the current bottleneck for #corona testing? Given that you can’t deliver @invitrogen @roche @QIAGENscience @BioRadLifeSci @promega @NEBiolabs & Co. Thanks. 👇

@EckerleIsabella

Isabella Eckerle

@EckerleIsabella

4 years

It’s mostly commercial extraction and testing kits, swabs, transport media, and (confidential) access to recipes from companies for their reagents would be most helpful - so we can look for local production units #SARSCoV2 #COVID19

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SonjaSchmid

7 months

Wishing all #SMBLesHouches attendees a wonderful meeting literally 'at the highest level'! Sad I miss it this year, but installing a brand new lab brings also high-level excitement. 😃 ...more soon... And have fun, Kasia & all!

@BiophysK

Kasia Tych

7 months

What a view to wake up to! Looking forward to meeting everyone and hearing about all of the exciting single-molecule science at the #SMBLesHouches meeting.

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SonjaSchmid

5 years

Thanks a lot @taekjip for setting up ! This can become a really helpful platform for the entire field. Also many thanks for linking to the . -> TimeTraceAnalysisFriends are still very welcome to participate btw. #kinSoft

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SonjaSchmid

2 years

The is in full interdisciplinary swing: last week we heard of #WillemKegel @UniUtrecht about cooperative phase transitions in hydrophobic polyelectrolytes... and today...:

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@sciSonja

SonjaSchmid

2 years

...and even more "DNA origami tools for single-molecule sensing" by @glembockyte from @PhilipTinnefeld at the #FRETsatellite

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@sciSonja

SonjaSchmid

3 years

Nice 'September Molecule of the Month' by the PDB @buildmodels showcasing 'DNA-Sequencing Nanopores':

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@sciSonja

SonjaSchmid

4 years

Dear #nanopore friends, don’t miss @cees_dekker 's talk this afternoon (2:40pm CEST). For the first time, he will present our #NEOtrap for long-term protein sensing using solid-state nanopores, plus many other exciting projects at #CDlab . See you online!😀

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@sciSonja

SonjaSchmid

5 years

'Revolutionary cryo-EM is taking over structural biology' Yes, and the next holy grail will be experimental protein DYNAMICS, kinetic rate models, energies etc. E.g. using #smFRET & #nanopores .

@Nature

nature

5 years

The number of protein structures being determined by cryo-electron microscopy is growing at an explosive rate.

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@sciSonja

SonjaSchmid

2 years

Great to see that more people join us in breaking the photo-bleaching limit in #smFRET : After our #DyeCycling paper (in print, ), here's @AchillesKap 's version of it 👇. 🎉 Let's enter the post-bleach era, FRETfriends!

@AchillesKap

Achillefs Kapanidis

2 years

Goodbye bleaching, hello REFRESHed fluorescence! Excited for Mirjam’s preprint on using transient DNA binding to get continuous single-molecule fluorescence for *1-hour*! Long-lived smFRET too! Big thanks to @majuiicb too.

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@sciSonja

SonjaSchmid

4 years

Don't miss the #smFRET & protein kinetics zoom seminar by Thorsten (my PhD advisor), who'll present parts of my former work & more. This Friday 3.30pm Amsterdam time. Open for all. 👇

@CeNS_LMU

Center for NanoScience LMU

4 years

This Friday at the CeNS zoom-colloquium: Prof. Thorsten Hugel @UniFreiburg , speaking about single molecule fluorescence as a tool to investigate molecular mechanisms in multi-component (protein) systems across a wide range of timescales. Please register:

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@sciSonja

SonjaSchmid

2 years

And so it starts: omw to #MAF2022 . See you soon, #FRET -friends! Let's see how @DB_Bahn will treat me this time... I book most of my euro-work travel thru them, since they cover everything from NL to Austria, from Sweden to Switzerland.👍 (Couldn't book Spain/France alas.)

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@sciSonja

SonjaSchmid

5 years

First time I see motion pictures of Prof. Marie Curie working in her lab.

@phalpern

Paul Halpern

5 years

Brilliant scientist Marie Curie, who received Nobel Prizes in both Physics and Chemistry, works in her laboratory at the Radium Institute in Paris, 1921 (Getty Images): #histSTM #WomenInSTEM #histsci #WomenInScience

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SonjaSchmid

2 years

...and many more of course: @cvdelannoy @NHatzakis @SMBLab @anders_barth @Lydia_Kisley @HugelLab plus all twitterless authors. Community-driven benchmarks make a field 💪stronger. Go #FRET -friends!

@NatureComms

Nature Communications

2 years

. @sciSonja @WUR perform a blind benchmark study assessing different analysis tools used to infer kinetic rate constants from smFRET trajectories, testing on simulated and experimental data

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SonjaSchmid

2 years

In the 2nd edition of the NanoBioPhysX series @DinaGrohmann blew us away with her inspiring talk: so many open questions – and how single-molecule resolution is a game changer for the molecular life sciences. Molecules to organisms and beyond! Many thanks Dina! 🙏🌻 #NBPXclub

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@DCSwarts

Daan C. Swarts

2 years

Very inspiring talk today @WUR about heterogeneity by the excellent @DinaGrohmann ! Thanks for starting the nanobiophysx seminar series @sciSonja and Jasper Landman! Can't wait for more :) (Only forgot to take a pic :( )

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SonjaSchmid

5 years

Cool, innovative approaches to single-molecule protein fingerprinting from The Netherlands: - by Chirlmin Joo @tudelft using #smFRET combined with DNA-PAINT . - by Giovanni Maglia @univgroningen using engineered protein nanopores. #SMPS2019

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SonjaSchmid

2 years

The #FRET family convened: #BenSchuler 's kicking off the #FRETsatellite meeting with a wonderfully instructive nsFCS lecture.

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@sciSonja

SonjaSchmid

3 years

Presenting our work today virtually @IowaBiochem . 16:30 CET. Infos👇. Thanks @maria_spies for the invitation! #proteinDynamics #smFRET #nanopores #NEOtrap Looking forward!

@IowaBiochem

Department of Biochemistry and Molecular Biology

3 years

Biochemistry Virtual Seminar: Dr. Sonja Schmid, March 25, 10:30 AM CST

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@sciSonja

SonjaSchmid

5 years

A first for me: no photo-bleaching involved... 😉 Observation time per single molecule is still crucial, though. 👇 #nanopores #preprint

@cees_dekker

cees dekker

5 years

Our latest #CDlab preprint: a review comparing noise in biological and solid-state nanopores, by #AlessioFragasso , @sciSonja and myself: Surprising conclusions: MspA biological pores have lowest noise but solid-state SiN pores have best signal-to-noise.

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@sciSonja

SonjaSchmid

3 years

Looks like there's something to celebrate tomorrow... 🙃🙂

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