Ta-da. A new paper published in
@NatureBiotech
😉 Are you working on phylogeny estimation or cell lineage tracing? Interested in computing an extremely large lineage tree? Please see this GIFtorial and try our new “deep distributed computing” system.
Developing a new sequencing-based assay? Please try out INTERSTELLAR, developed by our lab's bioinformatics master Yusuke Kijima🧙 INTERSTELLAR can interpret any sequencing read structure, and if you want, translate them into any other structure. 1/3
One of the recent cool things.
@t01545mh
hacked Amazon dash buttons linking them to our lab Slack so people can request common stuff easily! My favorite is the "someone in the room got cool data" button, removing the mental barrier of people to easily boast their success 😎
Our dual function CRISPR base editor paper is out
@NatureBiotech
✨ We developed Target-ACEmax that enables high-efficient simultaneous C->T and A->G editing in gRNA target sequences with minimal DNA/RNA off-target effects.
日本でも任期付きやテニュアポジションの数が議論になっていますが、そもそも大きく考え直して、皆が任期なし、5年おきに更新評価を受けるtenure time loopingがアカデミアの進化に良いのではないかという提言を
@NatureBiotech
に寄せました。国境を越えたアカデミア再考の種になればと思います。
Weekend readings in
@NatureBiotech
😌
@nika_shakiba
and I proposed a tenure time looping model where every PI undergoes tenure evaluation-like renewal evaluation every 5 yrs📷. There is also an insightful refutation by
@traingene
and
@vardi
.
The Yachie lab will move to
@BME_UBC
this summer! We are currently looking for talented students who are interested in synbiol and biotech development to decipher complex multicellular systems using DNA barcodes and genome editing. Check our website out!
A perspective piece from our group on the idea of DNA event recording is out in
@ScienceMagazine
😚 The field is growing really really excitingly. Come join this game!
Ta-da. A new paper published in
@NatureBiotech
😉 Are you working on phylogeny estimation or cell lineage tracing? Interested in computing an extremely large lineage tree? Please see this GIFtorial and try our new “deep distributed computing” system.
Thrilled to move the lab to UBC next summer and looking forward to the emerging science and enthusiasm there in BME and stem cell/developmental biology. Next phase. Will post details later.
I’m excited that our lab officially joins
@BME_UBC
today. Phase 2 of the Yachie lab! I am ready to fully commit to the new science and environment we will have here in Vancouver! Thank you
@UTokyo_Rcast
for investing us for the last six years. (1/7)
The April issue is live
On our cover, Konno et al. present a highly efficient distributed computing method for the reconstruction of evolutionary trees from very large datasets
I received the JSPS Prize this morning in front of Their Imperial Highnesses Crown Prince and Princess. Atsushi Miyawaki then gave me this surprise and thoughtful a bouquet at a meeting that I joined late.
The 1st publication of 2023 from our lab about a Rosetta Stone of sequencing reads in
@ScienceAdvances
. Amazing work by our bioinfomagician, Yusuke Kijima🧙♀️! This software INTERSTELLAR should be useful for the development of new sequencing-based assays.
Again I'm thrilled to move our team here to Canada through the
@CRC_CRC
program. We will establish a new foundation of mammalian synthetic biology to unlock many barriers in biological measurements. Stay tuned. We will do something crazy
@BME_UBC
!
New preprint from our lab! Seeing an interesting clone with an interesting phenotype emerging in a cancer/stem cell/yeast/E. coli population? Do you want to isolate them from the complex cell population ***before they show that phenotype?*** CloneSelect!
Excited to share our theoretical DNA-based Global Positioning System idea with
@geoffschieb
's lab, published in
@CellSystemsCP
!
Congrats to Laura, Anton, Yusuke, Matthieu, and the team! This amazing artwork capturing the concept was done by
@K_u___R_o
.
Our new lab website! (the previous one was just a prototype) One of the coolest lab websites I have ever seen!😎 Amazing artwork capturing the crazy and creative nature of our team by
@K_u___R_o
and amazing programming by
@Morihideponn
! Come visit!
Receiving a lightsaber from Fabio Rossi, I am the Director of Research
@SBME_UBC
starting today. Let's do just cool stuff. Let's calmly stand on our curiosities, discover wonders, find problems and solve them. Let's find ways to accelerate these.
I am honored to receive the JSPS Prize from the Japan Society for the Promotion of Science this year. This moment is a humbling reminder of the incredible support from my lab members, previous mentors, my wife Ayako, parents, grandparents, children, and friends.
OK... end of the day. Today I had some interesting discussion with my school and it was a great opportunity for me to organize my thoughts - so here is what I as a lab PI thinks which I'm prepared to revise. Any comments would be highly appreciated. (1/n)
Oh no, this is super cool!!! Rina C. Sakata of our team
@yachielab
got the University of Tokyo's Presidential *Grand* Prize for her undergraduate work... She continues to work with us
@BME_UBC
in Van. Congrats Rina!!! 🥳🎉 One of her undergrad works:
Hi students, when you apply to a lab for a grad student or postdoc position, I would recommend expressing your knowledge and interests in their researches and explain your ideas rather than saying "Dear Professor, my track record is great. Do you have a position for me?"
🏔I ask my lab to make a slide to report every data *on the day of experiments* with figures like in their admiring journal. Every neg data too. Exercise to make figs. Tossing neg data is stupid. They will collectively navigate you to the next.
#AcademicTwitter
#yachielabhacks
Pleeeeease RT and mark your calendar! 分生@福岡最終日12/6の1pmから武部貴則さんとシンポジウム「超細胞工学」を企画しています。先日ジュンアシダ賞を受賞された戎家美紀さん
@EbisuyaMiki
ら、次世代のスーパースターばかり集めました。生物学がまたさらに次のフェーズに移ります。
Published a lab guidebook "Nearly everything about the Yachie lab" here for the lab and whoever wonders about our lab philosophy and management in addition to our research. Big 🙏 to
@landrychristian
who shared theirs with me. Took time since I got it.
Benches installed in
@yachielab
Osaka. The same custom that we had in Tokyo back in 2014-2020 (inspired by the benches of my postdoc lab
@FPRoth
at
@SinaiHealth
). Kudos to the team especially
@Morihideponn
. Nostalgia.
@yachielab
UBC and Osaka will create good science together.
Vancouver was beautiful today. Went to Cypress🏔 backcountry trail with 12 yo and 8 yo. Black mountain trail was harder this year but they made it! Proud of them😊
Posted a new preprint to arXiv👋 We developed a Python package QUEEN to freely design synthetic DNA circuits and plasmids and generate GenBank format files. Yes... ok... does that sounds boring...? Well, it does something amazing (1/8)
QUEEN for efficiently describing and sharing reproducible 🧬 materials and construction protocols is published in
@NatureComms
. Kudos to our own
@Morihideponn
👏 Thank you to the reviewers to improve our manuscript and polish the software and ideas!
Very excited to be an Allen Distinguished Investigator with Nika
@nika_shakiba
and Josef
@penningerlab
! Thank you
@AllenInstitute
! We will rock mammalian synthetic development with our genome editing, cell barcoding, cell interaction, and organoid technologies.
End of a semester🥳 First time teaching at
@BME_UBC
. One with Fabio and one with
@nika_shakiba
. Students were actively involved. Love teaching here. Now what? The lab is warmed up a half year after the move. New members joined. Getting four keen summer students. Science!!🚀🤸🏎️🪂
Here we re-introduce GPS-seq, a theoretical framework for scalable, high-resolution spatial transcriptomics, with
@geoffschieb
's lab. Receiving several suggestions, we moved the methods to the main document and published the codes (thanks, Twitter!😌).
Weekend readings in
@NatureBiotech
😌
@nika_shakiba
and I proposed a tenure time looping model where every PI undergoes tenure evaluation-like renewal evaluation every 5 yrs📷. There is also an insightful refutation by
@traingene
and
@vardi
.
Excited to start teaching a new grad course BMEG591J "Designing High-throughput Biotechnologies"
@SBME_UBC
from this September🤩💪😎 Since (incoming) students have started registering courses while this is not posted yet, let me explain this new, tricky, crazy, fun course! (1/n)