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Giacomo Maddaloni Profile
Giacomo Maddaloni

@giac_madd

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Neurobiologist @harvard | Dymecki Lab | interested in 5-HT, running and electronic music, sometimes simultaneously | @Unipisa and @UninaIT alumnus

Boston, MA
Joined April 2017
Don't wanna be here? Send us removal request.
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@giac_madd
Giacomo Maddaloni
1 month
Can’t really find the words to describe how proud and enthusiastic I am to share the results of my postdoc work, just published in @nature . 6+ years of countless microscopy hours, innumerable surgeries, weeks-long experiments and sleepless nights 1/6
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@giac_madd
Giacomo Maddaloni
2 years
Yes, it's that time of the year again! Do you work in a US based institution and want to visit HMS Neurobiology, present your work, interact with faculty, fellow postdocs, and students? Apply to INCEPT! Deadline August 31, 2022.
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@giac_madd
Giacomo Maddaloni
1 month
We have discovered a subset of serotonin-glutamate neurons in the mouse median raphe that has the extraordinary ability to segregate serotonin vs glutamate to different axonal branches that innervate different regions 3/6
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@giac_madd
Giacomo Maddaloni
3 years
🌟Stellar lineup for our second #INCEPT @HMS_Neuro Seminar Series 🔥 See you there! #neuroscience #neurotwitter #neuroseminars
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@giac_madd
Giacomo Maddaloni
1 month
This axonal (but not soma 🤯) configuration is strikingly rearranged as a function of daytime lenght. Importantly, this novel form of neurotransmitter plasticity is necessary for timely synchronization of behavior to daylength changes. 4/6
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@giac_madd
Giacomo Maddaloni
2 years
What an amazing week. @HypothalamusGrc has been a blast! Thanks to @__Matt_Carter__ @michael_krashes @moccalin @JacksonLabUConn for organizing the best conference I’ve been so far!
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@giac_madd
Giacomo Maddaloni
6 years
Love night confocal sessions and damn look at those vasopressin fibers #sciart
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@giac_madd
Giacomo Maddaloni
1 month
@MicRoNHMS @Harvard_CBI @pattynora Finally, I am on the job market! And these findings will be the foundation of my future research, looking at seasonal remodeling of neural circuits underlying flexible behaviors. Hope you enjoy the read! 6/6
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@giac_madd
Giacomo Maddaloni
10 months
It was such a pleasure to share my work and interact with the MPFI neuro community! Amazing people and super cool science going on. And special thanks to @Zidan_Yang for being a great host!
@MPFNeuro
Max Planck Florida Institute for Neuroscience
10 months
We were thrilled to welcome our second NeuroMEETS postdoc speaker yesterday! Thanks @giac_madd for sharing your exciting science and future plans with us & for the great interaction & discussions. PhD students: you can still apply for our spring series!
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@giac_madd
Giacomo Maddaloni
1 month
To show what one reviewer has best described as “an important and carefully characterized violation of the long-standing rule that a neuron expresses the same transmitters in all of its terminals”. 2/6
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@giac_madd
Giacomo Maddaloni
11 months
Super excited to visit MPFI and meet the awesome scientific community there!
@MPFNeuro
Max Planck Florida Institute for Neuroscience
11 months
Max Planck NeuroMEETS is pleased to welcome four outstanding postdocs to share their science with us! @debo_Astrocyte @giac_madd from @TingtingZhou8 & Kevin Cury Apply for our graduate student series by Dec. 1!
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@giac_madd
Giacomo Maddaloni
13 days
Super grateful to @harvardbrainsci and the Dauten family for their generous support, which made this work possible!
@harvardbrainsci
HarvardBrainScience
13 days
. @harvardmed scientists have identified a mouse brain circuit with multiple groups of neurons that together recognize, decode, and drive behavioral adaptation to changes in the amount of daylight. From Susan Dymecki and colleagues. First author @giac_madd
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@giac_madd
Giacomo Maddaloni
5 years
New preprint from the lab is online! ‘A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons’ Check it out! #5HT #serotonin
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@giac_madd
Giacomo Maddaloni
2 months
Happy to share what is perhaps the last bit of my PhD work in @LabPasqualetti where we add another piece of the puzzle in understanding how alterations in serotonin signaling produces manic-like behaviors in mice > via blunting circadian dopamine rhythms!
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@giac_madd
Giacomo Maddaloni
1 year
What a stunning location, super excited for @CircuitBehavGRC GRS and GRC!
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@giac_madd
Giacomo Maddaloni
3 years
Come join a great lab and an outstanding research community! Please spread the word 🙏🏻
@neuromixologist
Yasmin Escobedo Lozoya 🇲🇽 👩‍🔬
3 years
Are you a mouse-whisperer looking for an RA position? Come work with us! Please RT 🙏
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@giac_madd
Giacomo Maddaloni
4 years
#INCEPT series @HMS_Neuro inaugural talk is just a bunch of days away! Our first speaker is Dr. Joel W Blanchard from @MIT (Wednesday December 9th, 12:45pm EST). The talk is open to the entire #neuro community, y'all can attend the event using the following YouTube link 👇🏻
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@giac_madd
Giacomo Maddaloni
2 years
Were you too busy and you missed the deadline? NO PANIC! Deadline has been extended. Applications are now welcome until Friday September 9th! Please spread the word 🙏 #incept @harvardbrainsci @harvardmed @HMS_Neuro
@giac_madd
Giacomo Maddaloni
2 years
Yes, it's that time of the year again! Do you work in a US based institution and want to visit HMS Neurobiology, present your work, interact with faculty, fellow postdocs, and students? Apply to INCEPT! Deadline August 31, 2022.
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@giac_madd
Giacomo Maddaloni
1 month
Couldn’t be more grateful to my postdoc mentor Susan Dymecki, to all lab members, core facilities ( @MicRoNHMS @Harvard_CBI ), to reviewers for their work, and to my partner in life @pattynora for never ending support! 5/6
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@giac_madd
Giacomo Maddaloni
5 years
Latest (but not the last?) work with @LabPasqualetti is now online! Check out how #5HT fiber density and morphology in the #hippocampus are dramatically affected by #fluoxetine treatment #serotonin #antidepressant
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@giac_madd
Giacomo Maddaloni
3 years
Come share your science with the @harvardmed @harvardbrainsci Neuro community TWO WEEKS LEFT TO APPLY! Please spread the word 🧠🔬
@harvardbrainsci
HarvardBrainScience
3 years
INCEPT @harvardmed Call for Applications: Talented postdocs affiliated with any US institution in the field of #neuroscience Share your research with the @harvardmed neuroscience community- candidates from diverse backgrounds are encouraged to apply! Deadline: 8/31 at 11:59PM EST
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@giac_madd
Giacomo Maddaloni
5 years
Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways: Current Biology
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@giac_madd
Giacomo Maddaloni
3 years
We are very excited to launch the 2021/2022 INCEPT series, open to postdocs affiliated with any US institution! Application Deadline August 31st. Spread the word #incept @harvardmed
@harvardbrainsci
HarvardBrainScience
3 years
INCEPT @harvardmed Call for Applications: Talented postdocs affiliated with any US institution in the field of #neuroscience Share your research with the @harvardmed neuroscience community- candidates from diverse backgrounds are encouraged to apply! Deadline: 8/31 at 11:59PM EST
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@giac_madd
Giacomo Maddaloni
5 years
Fluoxetine Induces Morphological Rearrangements of Serotonergic Fibers in the Hippocampus #5HT #serotonin #fluoxetine #hippocampus #antidepressants
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@giac_madd
Giacomo Maddaloni
3 years
Devastating and discriminatory. People with regular visas have been now stuck for almost 20 months without seeing their families, while citizens can freely go to Italy and enjoy la dolce vita
@SerenaTucci
Dr. serena tucci
3 years
This is devastating. EXCLUSIVE U.S. will not lift travel restrictions, citing Delta variant -official
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@giac_madd
Giacomo Maddaloni
4 years
It's almost time for the second #INCEPT series @HMS_Neuro talk! Our second speaker is Dr. @Molas__S from @UMass (Thursday February 11th, 12:45pm EST). The talk is open to the entire #neuro community, you all can attend the event using the following YouTube link 👇🏻
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@giac_madd
Giacomo Maddaloni
6 years
My PhD work is finally out! Lots of physical and mental efforts rewarded by wonderful collaborations and amazing results. Thanks to @LabPasqualetti , it was fun!
@LabPasqualetti
Massimo Pasqualetti
6 years
Check out our latest work online today: a constellation of different approaches elucidating the role of #serotonin in a new mouse model of #bipolardisorder . Amazing team work!! thanks to @giac_madd @AGiorgi19 @RaffaellaTonini @Gozzi_Ale @Ceinge
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@giac_madd
Giacomo Maddaloni
3 years
I wonder what is their processing time for the national interest exemption
@accnetwork
ACC Network
3 years
VIRGINIA TECH. ENTER SANDMAN. ABSOLUTE CHILLS. @HokiesFB
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@giac_madd
Giacomo Maddaloni
2 months
@lindsayschwarz @MartinBohlen1 I had a very similar issue. After lots of troubleshooting, ended up lowering the volume down to 15nl, injected with the Drummond Nanoject III (3 steps of 5nl each, 1 min apart, max injection speed), and waited 15 min before removing pipette. 70% success rate w/ these parameters.
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@giac_madd
Giacomo Maddaloni
3 years
Very excited to be part of this team! Check out our webpage () and don't hesitate to reach out to any Topic Editors for more info!
@Sciolino_Lab
Natale Sciolino, PhD
3 years
We are excited to host a Research Topic in 𝗙𝗿𝗼𝗻𝘁𝗶𝗲𝗿𝘀 𝗶𝗻 𝗡𝗲𝘂𝗿𝗮𝗹 𝗖𝗶𝗿𝗰𝘂𝗶𝘁𝘀, on "Deconstructing Neural Systems: From Molecular, Cellular & Circuit Properties to Behavioral Functions". Topic editors Susan Dymecki,Natale Sciolino,Giacomo Maddaloni,Alice Bertero
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@giac_madd
Giacomo Maddaloni
3 years
Check this amazing paper out!
@SfNJournals
SfN Journals
3 years
#JNeurosci : @SenftRebecca et al. show that a developmental lineage of serotonin neurons subdivides into two distinct r2-Pet1 neuronal subsystems: one involved with circadian rhythm and olfaction while the other affects memory and sensory processing.
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@giac_madd
Giacomo Maddaloni
1 month
👀
@Nature
nature
1 month
Nature research paper: Adaptation to photoperiod via dynamic neurotransmitter segregation
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@giac_madd
Giacomo Maddaloni
6 years
Conservation of prosocial function of MDMA in octopuses! #5HT
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@giac_madd
Giacomo Maddaloni
4 years
Accurate
@OdedRechavi
Oded Rechavi
4 years
Taking a pizza when you didn’t attend the seminar
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@giac_madd
Giacomo Maddaloni
2 months
@Gozzi_Ale @lindsayschwarz @MartinBohlen1 What really helped me in this regard was to go a bit deeper (200um) and then back up to create some sort of a pocket, as someone else said in this thread. After injection, I wait 7.5 min, raise the pipette 200um, wait another 7.5 min before fully retracting it. Hope this helps!
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@giac_madd
Giacomo Maddaloni
1 month
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@giac_madd
Giacomo Maddaloni
4 years
Check this out!
@neuromixologist
Yasmin Escobedo Lozoya 🇲🇽 👩‍🔬
4 years
Times have never been tougher if you are a postdoc in search of a job… But we can help each other out! In collaboration with the Neuropostdoc Club @harvardmed , @giac_madd and I are organizing the new invited postdoc series 'INCEPT'
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@giac_madd
Giacomo Maddaloni
2 years
Methamphetamine and PCP cause a population of prelimbic pyramidal neurons to switch from a glutamatergic to a GABAergic phenotype, and this remodeling promotes cognitive deficits Super cool work by @PratelliMarta , check this out!
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@PratelliMarta
Marta Pratelli
2 years
Very glad to share a preview of my latest work! #neurotransmitterswitching #Spitzerlab @gsk_swetha Phencyclidine and methamphetamine cause cognitive deficits by changing pyramidal neuron transmitter identity in the prefrontal cortex
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@giac_madd
Giacomo Maddaloni
3 years
Accurate
@UriCohen42
Uri Cohen, PhD
3 years
Types of neuroscience papers
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@giac_madd
Giacomo Maddaloni
5 years
Superresolution vs. confocal
@STEMSteph
Stephanie
5 years
Simulation vs REALITY!! We now live in a world where a black hole has been successfully photographed. WE’VE SEEN THE EVENT HORIZON!! #Scicomm #physics #STEM #BlackHole
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@giac_madd
Giacomo Maddaloni
4 years
Happening today! 👇🏻
@giac_madd
Giacomo Maddaloni
4 years
It's almost time for the second #INCEPT series @HMS_Neuro talk! Our second speaker is Dr. @Molas__S from @UMass (Thursday February 11th, 12:45pm EST). The talk is open to the entire #neuro community, you all can attend the event using the following YouTube link 👇🏻
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@giac_madd
Giacomo Maddaloni
1 year
Join us for the first INCEPT seminar of 2023 series! @harvardbrainsci @harvardmed
@LM_Ince
Dr. Louise Ince
1 year
Hello Boston! Join me tomorrow @harvardmed @HMS_Neuro discussing circadian rhythms in microglia, neuroinflammation, and aging. 🧠⏰️ thank you HMS INCEPT for the invitation. #chronobiology #immunology #neuroscience P.S. Good ducks!
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@giac_madd
Giacomo Maddaloni
2 years
I’ve watched this project develop over the last few years and I couldn’t be more proud! If you’re interested in functional (and dysfunctional) #callosalconnectivity and modulation of #cognition in a #mousemodel of #CDKL5 #autismspectrumdisorder , check this out! @PattyNora_Awad
@Gozzi_Ale
Alessandro Gozzi (is hiring)
2 years
Out today on @molpsychiatry new collaborative work led by #Michela_Fagiolini @harvardmed describing neural basis of brain connectopathy in #CDKL5 deficiency syndrome - #CDD - a common form of #Autism Well done Michela, Patricia, @Valerio_Zerbi & team!
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@giac_madd
Giacomo Maddaloni
2 years
⭐️Only 1 WEEK left! You don't want to miss out this amazing opportunity! ⭐️ Please RT 🙏
@giac_madd
Giacomo Maddaloni
2 years
Yes, it's that time of the year again! Do you work in a US based institution and want to visit HMS Neurobiology, present your work, interact with faculty, fellow postdocs, and students? Apply to INCEPT! Deadline August 31, 2022.
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@giac_madd
Giacomo Maddaloni
2 years
Can’t wait!!
@HypothalamusGrc
Hypothalamus Gordon Research Conference 2024
2 years
This is REALLY happening in 5 days!!!!!!!!
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@giac_madd
Giacomo Maddaloni
3 months
Apply! Can’t recommend it enough. Had so much fun sharing my work and interacting with MPFI faculty and trainees!
@MPFNeuro
Max Planck Florida Institute for Neuroscience
3 months
We had a fantastic end to this year's NeuroMEETS series with Gowri Somasekhar. Thank you Gowri and all of our 2023-2024 invited #postdocs and #gradstudent speakers. Applications open for next year's NeuroMEETS on June 1. Come share your science with us!
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@giac_madd
Giacomo Maddaloni
4 years
Do you even need refs
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@gottapatchemall
Alex Naka
4 years
The precarious position of postdocs during COVID-19
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@giac_madd
Giacomo Maddaloni
3 years
That graphical abstract 😍
@OdedRechavi
Oded Rechavi
3 years
Our “Distracted Worm” paper is finally published! Can transgenerational RNA inheritance bias crucial behavioral decisions for multiple generations? Read how stress controls the progeny’s mating preferences by boosting attractiveness 🔥💥👇
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@giac_madd
Giacomo Maddaloni
4 years
TODAY!!! #INCEPT
@giac_madd
Giacomo Maddaloni
4 years
#INCEPT series @HMS_Neuro inaugural talk is just a bunch of days away! Our first speaker is Dr. Joel W Blanchard from @MIT (Wednesday December 9th, 12:45pm EST). The talk is open to the entire #neuro community, y'all can attend the event using the following YouTube link 👇🏻
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@giac_madd
Giacomo Maddaloni
1 month
@lindsayschwarz @Nature Thanks so much! My feeling is that this is quite a widespread phenomenon, at least in neuromodulatory systems!
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@giac_madd
Giacomo Maddaloni
4 years
Wow!
@castren_eero
Eero Castren
4 years
Our paper is out now in Cell: Antidepressant drugs act by directly binding to TRKB neurotrophin receptor. Please check it out!
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@giac_madd
Giacomo Maddaloni
3 years
"Almost half of all US graduate and postdoctoral trainees in science and engineering hold temporary visas. However, almost all federal funding programmes are currently available only to US citizens and residents."
@deniswirtz
Denis Wirtz
3 years
Boost US federal funding for international trainees
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@giac_madd
Giacomo Maddaloni
4 years
I... don’t have a joke 😭
@neuromixologist
Yasmin Escobedo Lozoya 🇲🇽 👩‍🔬
4 years
Passing the mike to @giac_madd
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@giac_madd
Giacomo Maddaloni
3 years
@zenbrainest Planning on doing it in the near future - this will save us some work if it's available somewhere else!
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@giac_madd
Giacomo Maddaloni
3 years
A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility
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@giac_madd
Giacomo Maddaloni
7 years
Brain-wide Mapping of Endogenous Serotonergic Transmission via Chemogenetic fMRI ONLINE! #5HT #chemofMRI
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@giac_madd
Giacomo Maddaloni
7 years
Development of Serotonergic Fibers in the Post-Natal Mouse Brain #5HT #development #mouse
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@giac_madd
Giacomo Maddaloni
4 years
Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles
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@giac_madd
Giacomo Maddaloni
6 years
Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons
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@giac_madd
Giacomo Maddaloni
2 years
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@giac_madd
Giacomo Maddaloni
6 years
@AlexisNJameson You're not the only one! :(
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@giac_madd
Giacomo Maddaloni
5 years
@BenSaunders My lab has also made a R26 mouse line, works beautifully!
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Giacomo Maddaloni
4 years
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@giac_madd
Giacomo Maddaloni
5 years
@MargolisLab Very nice work. Another great example of the same strategy also here:
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Giacomo Maddaloni
3 years
@LlopisMontero @zeiss_micro My pleasure 😄 for the love of science!
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@giac_madd
Giacomo Maddaloni
6 years
Latest work from the lab! Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery #5HT #serotonin
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@giac_madd
Giacomo Maddaloni
2 years
Literally bright days ahead 🧠✨
@neuromixologist
Yasmin Escobedo Lozoya 🇲🇽 👩‍🔬
2 years
Good things come to those who wait @MiniscopeTeam 😌🙏
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@giac_madd
Giacomo Maddaloni
4 years
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Giacomo Maddaloni
4 years
@yesloz @sarah_stern I’ll never understand the different formats! It would be much much better if journals agreed on a common one
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@giac_madd
Giacomo Maddaloni
4 years
This
@markwarschauer
Mark Warschauer 🇺🇦
4 years
A thread Yesterday, ICE announced that international students cannot remain in the US if they are taking online classes in the fall. For my friends who are not in academia and may thus be unfamiliar with the context, I wanted to explain why this is such a horrific decision 1/
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@giac_madd
Giacomo Maddaloni
4 years
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@giac_madd
Giacomo Maddaloni
4 years
@LlopisMontero Exactly. What about the constant anxiety that people with a temporary visa live with during these times? Science is great in this country because it’s international
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@giac_madd
Giacomo Maddaloni
5 years
Deep learning of spontaneous arousal fluctuations detects early cholinergic defects across neurodevelopmental mouse models and patients
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@giac_madd
Giacomo Maddaloni
6 years
SIDS: Serotonin neurons contribute to fail-safe mechanism that ensures recovery from interrupted breathing
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@giac_madd
Giacomo Maddaloni
1 year
@Sara_Sawyer_ @eLife Thanks for sharing! What is the reason papers are not being sent out? Scientifically/methodologically unsound? Lack of reviewers w/ relevant expertise?
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@giac_madd
Giacomo Maddaloni
4 years
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@giac_madd
Giacomo Maddaloni
4 years
Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals
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Giacomo Maddaloni
4 years
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@giac_madd
Giacomo Maddaloni
4 years
“One day, it’s like a miracle, it will disappear”
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@giac_madd
Giacomo Maddaloni
4 years
Tomorrow! #INCEPT
@giac_madd
Giacomo Maddaloni
4 years
#INCEPT series @HMS_Neuro inaugural talk is just a bunch of days away! Our first speaker is Dr. Joel W Blanchard from @MIT (Wednesday December 9th, 12:45pm EST). The talk is open to the entire #neuro community, y'all can attend the event using the following YouTube link 👇🏻
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@giac_madd
Giacomo Maddaloni
2 years
P.s. yes I did miss an evening session to go see the sunset!
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@giac_madd
Giacomo Maddaloni
4 years
An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents
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@giac_madd
Giacomo Maddaloni
2 years
@Sciolino_Lab @ScienceAdvances Congrats, Natale! Looking forward to reading it
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Giacomo Maddaloni
4 years
Businesses Chafing Under Covid-19 Lockdowns Turn to Armed Defiance Welcome to America
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Giacomo Maddaloni
4 years
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@giac_madd
Giacomo Maddaloni
3 years
Mouse olfactory bulb
@GinaGoesOutside
Gina Lloyd
3 years
summoning a knower of clouds to explain this to me. what the heck
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@giac_madd
Giacomo Maddaloni
4 years
@yesloz Or not having a joke can be the joke itself
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Giacomo Maddaloni
2 years
@superkash Yes, got much better labeling with FG staining
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@giac_madd
Giacomo Maddaloni
4 years
This. Concerning that other hard-hit states' testing is going way down. SPOILER: Arizona, Florida, Texas.
@NYGovCuomo
Archive: Governor Andrew Cuomo
4 years
More testing only uncovers more positives when there are positives to be found. In New York, daily new cases have gone down as testing has gone up.
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@giac_madd
Giacomo Maddaloni
3 years
Call to update US re-entry rules for international researchers
0
2
2