Thrilled to share our new story in
@CellStemCell
- a tour de force team effort spearheaded by
@tchlon
. He identified that DDX41 mutations contribute to MDS through discrete mechanisms in monoallelic and biallelic mutant clones.
We are excited to share our new paper in
@haematologica
describing the complex relationship between
#inflammation
,
#p53
, and
#MDS
. Congrats to lead author Tomoya Muto for spearheading the project.
Very proud that our lab was awarded the highest level of certification by
@My_Green_Lab
- the 1st at
@CincyChildrens
and in
#Ohio
! The
#GreenLabCertification
is the gold standard in lab sustainability practices. Huge thanks to Lyndsey Bolanos and our “sustainability champions”!
We are excited to share our latest paper in
@BloodJournal
describing new functions of the IRAK1 & IRAK4 complex in MDS/AML, which has broad therapeutic implications.
Congrats to Tomoya and Maria (
@Maguillamot
) on their new story in
@CellStemCell
- a tour de force team effort between the Starczynowski and
@iannisaifantis1
labs on a new tumor suppressor role of TRAF6 in
#AML
by targeting MYC activity:
Excited to share our
@JExpMed
perspective on the emerging role of innate immune signaling dysregulation in hematopoietic aging, clonal hematopoiesis, and MDS. Huge thanks to the
@TrowbridgeLab
and
@dstarczynowski
lab members!
Join us for the rescheduled but equally exciting Virtual Keystone Symposia April 21-23 2021 on the latest research in normal and malignant hematopoiesis.
#VKSHemato21
We are excited to share our latest paper in
@iScience
describing the complex role of dysregulated innate/inflammatory signaling in the progression of
#MDS
to
#AML
with RUNX1 mutations.
Congrats
@Maddie_Science
! It is a bitter sweet day as it is her last day in the lab after a widely successful PhD. She is embarking on her postdoc with John Crispino
@StJudeResearch
. Maddie is a science rockstar and an awesome colleague! We will all miss her
@CincyChildrens
.
If you are interested in how inflammation can impact
#MDS
, check out our new pre-print in
@biorxivpreprint
: Chronic inflammation suppresses del(5q)-like MDS HSCs via p53
Happy to see the final version of our paper in the latest edition of
@BloodJournal
. In this paper, we describe new functions of the IRAK1 & IRAK4 complex in myeloid malignancies, shedding light on its therapeutic implications.
We are excited to share our latest paper in
@BloodJournal
describing new functions of the IRAK1 & IRAK4 complex in MDS/AML, which has broad therapeutic implications.
Join us for the Keystone Hematopoiesis eSymposia April 21-23 2021. Deadline for short talks is March 10. Priority will be given to trainees and junior faculty. Email or DM if you have questions.
#VKSHemato21
If you want to learn more about the emerging role of inflammation and cell-intrinsic dysregulation of innate immune pathways in
#myelodysplasia
, see the list of recent reviews. Tag me if there are any I've missed.
The Hematologic Malignancies Program
@CincyChildrens
is recruiting tenure-track faculty to pursue research on normal and malignant hematopoiesis. Retweet and share with your colleagues.
Happy to see the final version of our paper in the latest edition of
@Haematologica
. We show that innate immune pathways contribute to MDS and that chronic inflammation may create a selective pressure for expansion of p53 mutant clones in del(5q) MDS.
We are excited to share our new paper in
@haematologica
describing the complex relationship between
#inflammation
,
#p53
, and
#MDS
. Congrats to lead author Tomoya Muto for spearheading the project.
If you are interested in learning about the role of IRAK1 and IRAK4 in hematologic malignancies and recent therapeutic advances in the dawning era of IRAK-targeted therapy, check out Josh Bennett's new review in Current Opinion in Hematology:
Excited to share our new story in
@CellReports
- a tour de force by
@Maddie_Science
. She identified TIFAB as a critical node in hematopoietic cells under stressed and oncogenic cell states.
Thank you
@LLSResearch
@TheMarkFdn
@AllenInstitute
! I’m very grateful and honored to be among the recipients of the inaugural Blood Cancer Discoveries Grant. Congrats to the other recipients!
Congratulations to Maddie for successfully defending her PhD thesis! She totally knocked it out of the park. This is no surprise as she is a science rock star!
@uc_ccb
@CincyChildrens
Tomorrow is the official kickoff to the
#Keystone
#eSymposia
on Hematopoiesis! Looking forward to amazing science and connecting with colleagues. See you all soon!
Welcome all out of town guests to Cincy for
#MyeloidMeeting22
! Looking forward to seeing everyone and the science! If you arrived early, check out entertainment/dining options at The Banks (riverfront), OTR, and Central Business District. LMK if you want recommendations.
Yesterday was our annual UC Cancer Center Retreat - an exciting day of cancer research talks, vibrant discussions, and new collaborations! Lot’s of energy and amazing cancer research happening at
@UCincyMedicine
and
@CincyChildrens
!
Congrats to
@Amitvermamds
, Jackie Boultwood, and the entire team! Excited to be part of this study on the role of
#IRAK4
in
#MDS
with SF3B1 mutations.
Congrats to the Kurome Tx team for the FDA's IND approval of KME-0584! Exciting progress in advancing IRAK1/4 therapies to patients. This milestone marks a significant step forward in the fight against
#AML
and
#MDS
.
Huge congrats to
@CincyChildrens
for achieving
#1
US News ranking! Immense gratitude to our exceptional teams, whose unwavering dedication, innovation, and compassion deliver world-class care and impact. I’m proud to be part of this amazing team!
Excited to share our new study in
@ScienceTM
by
@Kate_Mel_
on a novel therapeutic strategy for overcoming adaptive resistance to therapy in AML by targeting immune response pathways. Check out the link
@AAAS
Exciting paper in
@CD_AACR
from Yoshihiro Hayashi and team at Tokyo University (
@toyaku_univ_pr
). They show mitochondrial fragmentation triggers ineffective hematopoiesis in
#MDS
in part via ROS production and inflammatory signaling. Congrats to the team!
Save the Date!
#ISEH2024
🎡 will be hosted in Chicago, USA from 29 August - 01 September 2024. Details on the scientific program, networking opportunities, and registration to come in early 2024 - but add us to your calendars now!
Join us for an exciting
@KeystoneSymp
April 3-7 2020 on the latest research in normal and malignant hematopoiesis. Check out the speaker lineup, meeting info, and presentation opportunities.
#KShemato
.
One of my favorite events…our annual
@ChildrensCBDI
research retreat bringing together our oncologists, hematologists, scientists, and trainees. Awesome presentations and spirited discussions!
@CincyChildrens
#1
New study from the team at
@MoffittNews
implicating immune signaling in
#MDS
: Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS-STING-NLRP3 axis in
#MDS
@JCI_insight
Exciting news!
@FortuneMagazine
has once again recognized
@CincyChildrens
as the nation's most innovative children's hospital! Huge shoutout to the incredible faculty and staff pushing the boundaries of child healthcare innovation.
Congrats to LaQuita Jones for her paper
@jclinicalinvest
on targeting AML-associated FLT3 mutations. With Craig Thomas’ team
@ncats_nih_gov
, we describe a novel IRAK1/4-FLT3 inhibitor that targets clinically-relevant FLT3 mutations:
Congratulations to the amazing team at Kurome Therapeutics for their financing round. Exciting to see the the development of drugs targeting IRAK1/4 signaling pathways in cancer.
#MDS
#AML
#Cancer
Kurome Therapeutics Announces FDA Clearance of Investigational New Drug (IND) Application for KME-0584 for the Treatment of Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndromes (MDS)
There is only 1 week left to submit an abstract for the
@KeystoneSymp
April 3-7 2020 on the latest research in normal and malignant hematopoiesis. Check out the updated meeting info ().
#KShemato
If you want to learn more about the role of FHA-domain proteins in inflammation, hematopoiesis, and disease see our recent review
@ISEHSociety
. Kudos to
@Maddie_Science
and
@Puneet1080
for an awesome job!
One of my favorite events…our annual
@ChildrensCBDI
research retreat bringing together our oncologists, hematologists, scientists, and trainees. Awesome presentations and spirited discussions!
@CincyChildrens
#1
Dr Starczynowski speaking at mdacc today.
@LeukemiaMDA
@dstarczynowski
Fantastic talk and topic from a leader in field of innate immune alterations in cancer.
Important study from Dan Link’s team in
@BloodJournal
: Increased dendritic cell TLR1/2 signaling may contribute to altered HSPC function in
#MDS
by increasing local IL-1b expression.
Interested in mechanisms of therapy resistance in blood cancers? Attend the first ASH Workshop on this topic co-organized by Dan Starczynowski
@dstarczynowski
, Christina Glytsou
@glytsou
, and myself during
#ASH23
: 1/
Thank you for highlighting our review on the IRAK1 & IRAK4 kinase complex and its potential as a therapeutic target in inflammatory conditions and oncology!
🚨 Sharing our top read papers of 2023! 🚨
The review of therapeutic advances in the dawning era of IRAK-targeted therapy, from Joshua Bennett & Daniel Starczynowski
@dstarczynowski
from
@CincyChildrens
is our top read review of 2023!
🔗
Read more ⬇️
NCI is increasing the R01 payline to the 12th percentile in fiscal year 2023, up from the 11th percentile in FY22—bringing the institute’s payline to a level not seen since 2010.
Congratulations to Tim Chlon, PhD (
@tchlon
), on being selected along with 32 other recipients for the 2023
@ASH_hematology
Scholar Award. Read the full announcement:
There is only one week left to apply for
@KeystoneSymp
Hematopoiesis Meeting Scholarships (deadline Dec. 5): .
Not only are KS Scholarships prestigious, but they also provide invaluable networking and career-development opportunities.
MDS Workshop starting today. Experts will discuss the critical steps & approaches required to advance the field of
#MDS
and its treatment paradigm. Virtual option available.
@Dr_AmerZeidan
@garciamanero
New MDS funding opportunity: The new Taub Foundation Pilot award will provide seed money for transformative ideas in MDS. The award supports proof-of-concept studies addressing critical roadblocks to understanding MDS and its treatment.
The German company BioNTech, founded by 2 scientists - husband/wife team - has teamed up with Pfizer on leading their RNA-based vaccine for Covid-19. Their inspirational story
@nytimes
.
@tmprowell
I usually get "Steinman" or "Stensman". I've heard Raf Bejar introduced as "Bee-jar" like a Mason jar full of honeybees (he's Uruguayan descent, so the j is like an h), and some moderators don't even know where to start with Dan Starczynowski
@dstarczynowski
or Ari Giagounidis.
The 2023 Dresner Foundation MDS Research Fund is open for applications! Deadline = March 17. Please share with your colleagues.
@aamdsif
@MDSFoundation
@MDSAlliance
There is only a few days left to submit an abstract for the
@KeystoneSymp
April 3-7 2020 on the latest research in normal and malignant hematopoiesis! Abstract are due Jan 9th, 2020. Check out the latest meeting info ().
#KShemato
.
Devastating news and huge loss for
@CincyChildrens
. Hector was an amazing leader and colleague, and a world-class physician-scientist. He was instrumental to advancing our clinical, research and education missions. Our heartfelt condolences to his family. He will be deeply missed
It is with deep sadness that we mourn the loss of Hector Wong, MD, vice chair of the Department of Pediatrics at Cincinnati Children’s and a leader in critical care medicine research, who passed away unexpectedly over the weekend. He was 58.
I am really pleased to share our latest manuscript, just published
@Nature
! You can access the manuscript (open access) here:
Special thanks to Maria Carolina Florian for the great commentary:
The Vera and Joseph Dresner Foundation’s is accepting Letters of Inquiry for its
#MDS
Research Fund. Early Career and Established Investigators are invited to apply. Deadline = March 15, 2024
One of my favorite events…our annual
@ChildrensCBDI
research retreat bringing together our oncologists, hematologists, scientists, and trainees. Awesome presentations and spirited discussions!
@CincyChildrens
Congrats to Tomoya Muto for the Outstanding Abstract Achievement Award at
#ASH19
! He’ll be presenting Monday (Session 603 - abstract 727) on a novel mechanism of MYC activation in AML/MPN.
After
@anandi_krishnan
, be sure to stay signed in for THURSDAY TRAINEE HOUR 🥳from 2-3pm EDT. Today we will be treated to talks from
@LMHaynesPhD
,
@tchlon
, and Massiel Stolla.
ISEH is proud to announce the winners of our 2024 Society Awards!
Scientific Award Winners: Emmanuelle Passegué, Ravindra 'Ravi' Majeti and Robert Signer
Leadership Award Winners: Ross Levine and Katherine King
Read more about this year's winners here 👉
Congratulations
@Maddie_Science
! Obviously you will be terribly missed by all of us in the lab, but I am very excited to see you continue on your amazing scientific journey with John Crispino
@StJudeResearch
!
You know that excitement of college signing day, when athletes put on the hat for their new team?
Ok so I’m definitely not a college athlete but I feel that sense of excitement to share that for my postdoc, I’ll be joining John Crispino’s lab
@StJudeResearch
in January. 😀🩸🔬
Wondering about
#Cincinnati
because...
@Bengals
?
Some things to know. 🧵
Cincinnati was a boomtown in the 1800s—one of the 10 largest cities in USA for most of the 19th century. So..
Our
#architecture
is a stunner—it looks like lower Manhattan b/c it was built at the same time.
Welcoming news from FDU (my alma mater) for many still struggling financially during the pandemic. Hope other institutions follow and reduce tuition during these times so all students can continue their studies!
#myfdu
Not one but TWO talks for me at
#ASH21
. I will present my lab’s most recent findings on DDX41 mutations in MDS at the Scientific Workshop on Bone Marrow Failure on Friday and on Saturday 12-1:30pm in session 636 MDS: Basic and Translational
@ASH_hematology