Robert Chen MD PhD @PerceptronMD Twitter profile | Pikagi

Pikagi

Robert Chen MD PhD

@PerceptronMD

508

Followers

346

Following

51

Media

3,137

Statuses

slowly aging physician/scientist 🫀🧠🏃‍♂️ @weillcornell

Joined January 2020

Don't wanna be here? Send us removal request.

Pinned Tweet

@PerceptronMD

Robert Chen MD PhD

10 months

Peter Attia’s exercise recommendations are impossible for a lot of Americans - people with kids, people working 14-hour days or night shifts and can’t make it to a gym during normal times, people that can’t afford gym memberships/squat racks etc.

Tweet media one

2

0

7

Last Seen Profiles

@Grayscale

@tydessin

@caringcritical

@princesshimeko_

@BBCNews

@pete02827983252

@army_yuzur

@andreswifitv

@KTmBoyle

@tartaliauzine

@QJoto50879

@blkgirlpussy

@imaginarypix

@mpost_io

@HarryTradesYT

@UcesaAg39917

@oneofyen

@kinatash

@johnypitts

@Genki119

@sreistv

@KCPhotographyEU

@Kr59521

@otochan_115

@anushkmittal

@UVA_EM

@SugarNadya

@NonLeagueDad

@abrandylion

@EvreneKotuMesaj

@orangejuicetm

@AyeeshaTY_

@ManvelHS

@SSaludCdMx

@for_birmingham

@Angy17188

@PerceptronMD

Robert Chen MD PhD

3 years

@ben_j_lindsay “Data scientist” sounds a bit cooler than “CSV file processor”

0

1

24

@PerceptronMD

Robert Chen MD PhD

5 years

@colleenmfarrell seems like a problem of incentives rather than fairness. Nurses get $10K+ per week. But they could simply stay at home, flatten the curve, and suffer no repercussions. Residents that don't show up to work, won't graduate from residency and won't get a medical license.

2

1

22

@PerceptronMD

Robert Chen MD PhD

3 years

@AminSense @Narniarawr On these exams you can often times generalize a set of answers into: A) duck B) duck C) platypus D) duck E) duck F) duck

2

0

8

@PerceptronMD

Robert Chen MD PhD

6 months

Anaerobic fitness is a more useful indicator of fitness. Plenty of unfit, overweight people can slog their way through a marathon just like would through other tough emotional experiences. But they wouldn't be able to deadlift twice their body weight if their life depended on it.

15

1

6

@PerceptronMD

Robert Chen MD PhD

4 years

@bertcmiller Upcoming PhD thesis. On the blockchain. @aaronmrosado @vineettiruvadi @SaumyaGurbani @Ace_Harsh @LavinComputes @patrickf2601 @YM_Chang @piyusch

1

0

7

@PerceptronMD

Robert Chen MD PhD

6 months

@hjluks This is why the high intensity weight training should start at age 25 instead of 55 or 65. 30 years is a lot of time to save up strength, mass and neuromuscular ability. 5-10 years (before your first fall) is not.

1

2

7

@PerceptronMD

Robert Chen MD PhD

5 months

Daily 3/3/3++ strength challenge. 3+ movements 3+ sets 3+ reps. Strength deteriorates by 1-4% a year after your 20s. Most doctors/researchers know this but don't strength train themselves. Do you put in a few $ every month into your 401k? You can do the same for your strength

2

1

7

@PerceptronMD

Robert Chen MD PhD

4 months

@B_Holmer @evolutionarypsy People need to stop thinking about biological age as one number. It's convenient to do that and brag about your score in a way that resonates with silicon valley engineers but there are multiple domains of aging - artery age, hair loss age, personality age, skin age, etc ..

1

1

6

@PerceptronMD

Robert Chen MD PhD

4 months

This is an engineering problem that likely will have an (bio)engineering-based solution within the next 500 years

@Paddy_Barrett

Dr Paddy Barrett

4 months

If you are too busy to exercise, then you are too busy. Physiology does not care about your schedule.

8

33

208

2

0

6

@PerceptronMD

Robert Chen MD PhD

2 years

The incentive structure in the research ecosystem is broken. Shame that decentralized experiments aren’t up and to the right, arXiv has no token, etc. @lab_dao @HairDAO_ @Molecule_dao @db_dao

@alz_zyd_

alz

2 years

Nice passage about how academic/publishing incentives potentially set polymer chemistry back a few decades. If it's not a small molecule pure compound why would it be interesting???

Tweet media one

3

1

32

1

0

6

@PerceptronMD

Robert Chen MD PhD

9 months

@Alan_Couzens 1>2>3 is fine for kids or people without jobs with lots of free time. 3 > 1 > 2 should be the order for average working class people. More bang for your buck and anaerobic capacity more important for tasks of daily living (saving yourself from a fall, getting out of your chair).

4

0

6

@PerceptronMD

Robert Chen MD PhD

4 months

Your muscle mass is important, and so is the stuff you can do with it! July fitness challenge 1 sprint interval = 2 points 5 mins zone 1 or 2 = 1 point Aim for 60 points/week (~5 hrs total; 10-16 points high intensity, 44-50 points low intensity)

@Vote_ForPedro

Pedro Teixeira MD PhD

4 months

It’s the last day!!! 🎉 The June 3/3/3/30 Lift Challenge comes to a close today! 🙏 Thank you all so much for joining me! This is definitely a habit I’ll continue with some modifications. Let me know if you’d like me to keep posting. Happy to share my workouts but never

3

0

5

2

0

5

@PerceptronMD

Robert Chen MD PhD

5 months

@Oh_Cee_Dee @johngetstrong Another way to do it is to run as fast as you can for 30 min and average out the last 20 min. Use that heart rate as your lactate threshold. Then calculate your zone 2 with Joe Friel's calculator. In a way this is better because some people can talk while breathing heavy.

0

0

2

@PerceptronMD

Robert Chen MD PhD

7 months

What they tell you in medical school: Insulin resistance is the number one modifiable driver for all chronic diseases. What they don’t tell you in medical school: inadequate physical fitness is the number one modifiable risk factor for insulin resistance.

0

2

4

@PerceptronMD

Robert Chen MD PhD

6 months

This shouldn’t be hard for a serious athlete to grasp. VO2max is confounded by skeletal muscle strength, power, etc. it’s really a composite metric. People with high VO2max have strong legs. You can’t even do the Peter Attia life extension workouts if you are weak.

@BowTiedRunning

BowTied Runner

@BowTiedRunning

6 months

Problem with VO2 max is people think there's a "pill" for it. Doing one Peter Attia HIIT protocol a week isn't going to move the needle. It's more like years of work and *at least* 5+ hours (on the low side) of volume per week for a normal person to get into a place where you

38

11

201

2

0

6

@PerceptronMD

Robert Chen MD PhD

2 years

Review of computational (eg deep learning) antibody design #deeplearning #machinelearning

@OPIGlets

Oxford Protein Informatics Group (OPIG)

2 years

Check out our latest review on "Advances in Computational Structure-Based Antibody Design", led by @AlissaHummer and @brennanaba !

0

7

34

0

0

4

@PerceptronMD

Robert Chen MD PhD

2 years

Decentralized identity should be used for credentialing / enforcing permissions

1

2

5

@PerceptronMD

Robert Chen MD PhD

8 months

If you’re committed to taking 200 pills full of vitamins and minerals every morning, you are better off just taking rapamycin and spending the rest of that life-extension self-care time taking care of your kids

0

1

6

@PerceptronMD

Robert Chen MD PhD

8 months

@ethanjweiss Even if there are a few token individuals with sky high LDL and don’t develop ASCVD,who cares. For majority of people, lowering LDL lowers ASCVD risk. It’s inane to brag about a negative coronary angio despite high LDL as a 25 year old when calcified plaques take years to form.

0

0

4

@PerceptronMD

Robert Chen MD PhD

5 months

It's long been evidenced that aerobic training and resistance training confer overlapping benefits in endothelial function. But statistically, isometrics yield nearly 2x better blood pressure improvements

@DanielBerglind

Daniel Berglind, PhD

@DanielBerglind

5 months

Meta-analysis of RCTs: exercise lowers systolic (SBP) + diastolic (DBP) blood pressure: -aerobic exercise 🏃🏼‍♀️➡️ −4.49 SBP/–2.53 DBP mmHg -resistance training 🏋🏻 ➡️–4.55/–3.04 mmHg -HIIT🥵➡️ –4.08/–2.5 mmHg -isometric resistance training🏋🏻 –8.24/–4.00 mmHg

2

39

120

0

0

4

@PerceptronMD

Robert Chen MD PhD

8 months

@MichaelAlbertMD Guess who the audience will listen to-the engineer on twitter that brags about being an outlier himself, and then claims Oreos are the way to prevent ASCVD. Because the average person relates more to a random loud-mouth 20-something year old.

2

0

5

@PerceptronMD

Robert Chen MD PhD

8 months

Week 7: 16 mi, 175 min, avg HR 147, max HR 156, 16 mi Z1/Z2, 0 mi Z3/Z4/Z5

1

0

1

@PerceptronMD

Robert Chen MD PhD

5 years

@VPrasadMDMPH Since thousands of covid patients have already died, they should just use a synthetic control arm. #science @zachweinberg @flatironhealth

2

0

5

@PerceptronMD

Robert Chen MD PhD

5 months

If you're willing to skirt the rules around clinical validation, there is so much you can glean from urine metabolomics, e.g. Nightingale's NMR panel. Noneed to see a phlebotomist to collect specimen; eventually you could have this done daily at home.

Tweet card media

Webinar May: Urine metabolomics by Nightingale NMR

This is "Webinar May: Urine metabolomics by Nightingale NMR" by Nightingale Health on Vimeo, the home for high quality videos and the people who love them.

0

1

5

@PerceptronMD

Robert Chen MD PhD

3 years

@MigsRunner @arghavan_salles Think the line should be drawn when it gets to the point where after an extended period of time others (scrub tech, PA, medical student etc that don’t speak the language) start to feel awkward. Maybe it’s just the medical student scrubbed in in this case.

1

0

5

@PerceptronMD

Robert Chen MD PhD

1 year

A lot of us are still waiting on a “TAME but for rapamycin” trial…let’s pick up the pace

@mkaeberlein

Matt Kaeberlein

1 year

It's a false narrative that longevity interventions haven't translated well from invertebrates --> mice. This is not supported by data. It's not true. Plenty of examples have translated. Show me some that robustly and reproducibly work in invertebrates but clearly do not in mice

4

10

67

1

0

5

@PerceptronMD

Robert Chen MD PhD

8 months

MD-PhD students thrive off of low hanging fruit are more likely to make this transgression than PhD-only students

@alz_zyd_

alz

8 months

Some PhD students seem to think a good way to find research ideas is to read the conclusions paragraph of good papers, and do the things authors say are natural next steps for research This is a terrible idea! Absolutely terrible! It is hard to do worse than this!

18

21

320

0

0

2

@PerceptronMD

Robert Chen MD PhD

2 years

@aloktayi @Shamburgularara @VibeBio It probably needs to be partnered with an accelerator. Traditional academic departments may not be open to such an arrangement especially since traditional academic research doesn’t always lead to profitable IP.

0

1

4

@PerceptronMD

Robert Chen MD PhD

7 months

Knowing which glycans dominate your immunoglobulins (GlycanAge) is "cool", but for now, its just "cool". A lot more creativity and rigorous validation is needed in order to identify and battle-test clinically meaningful use cases.

@UMDLaw

Maryland Carey Law

7 months

Professor Diane Hoffmann (with others) publishes article arguing for more regulation to prevent consumer harm in the DTC microbiome testing industry. Posted today in @ScienceMagazine

1

3

20

1

0

3

@PerceptronMD

Robert Chen MD PhD

5 months

@biogerontology @hautskintech CCTV in Asia should be analyzing people's faces/skin to understand biological age. If anyone can roll out a population-wide screening tool that requires minimal effort on the patients part, its the Chinese.

0

0

1

@PerceptronMD

Robert Chen MD PhD

2 years

@vineettiruvadi Choice 4: Petition the medical school to remove step 2 as graduation requirement

1

0

4

@PerceptronMD

Robert Chen MD PhD

8 months

@biogerontology @nvidia @ZevFima Jensen says “bioinformatics”, “genomics”, etc in literally every presentation he gives….make of that what you will

0

0

4

@PerceptronMD

Robert Chen MD PhD

5 months

@Vote_ForPedro @nicknorwitz This paper 1. Should not have gotten into Science, 2. Seems like an attempt to dunk on ketogenic diets. Besides the diet composition, it is entirely focused on the senescence aspect and doesn't interrogate other commonly reported physiological adaptations to such diets.

1

0

2

@PerceptronMD

Robert Chen MD PhD

7 months

@MichaelAlbertMD The point is not that BMI should not be the standard metric. It's that BMI benefits from being easy to measure without extensive tools compared to visceral fat, total fat, muscle mass, physical function and fitness

1

0

4

@PerceptronMD

Robert Chen MD PhD

6 months

VO2max is the most important factor for your longevity (if you believe Mandsager et al). However, only 20-25% of Americans exercise. The majority of this 20% do so unintelligently. Very few people are actually winning here.

0

0

3

@PerceptronMD

Robert Chen MD PhD

4 months

@Vote_ForPedro @BiggestComeback @lindy_lou_j @MarkBski @Kenharrison99 @ItIsMikeFitz Kettlebells are great! Weighted deadbug x3x10 Knee extension x3x10 Glute bridge x3x10 Side lying hip abduction x3x10

1

0

4

@PerceptronMD

Robert Chen MD PhD

4 years

Can’t see Can’t PiSS Can’t SPit Can’t Shit Clozaril zyPrexa Seroquel #MedTwitter #doubledocs #Health #neuroscience #neurotwitter #mentalhealth #psycho

0

0

4

@PerceptronMD

Robert Chen MD PhD

4 years

@jmyld they usually include details about sexual activity, alcohol/drug use as well. "Is/is not sexually active with XYZ individuals. Drinks X shots of vodka per night."

0

0

4

@PerceptronMD

Robert Chen MD PhD

4 months

If you don't know how to exercise, random chance can help you...

Tweet media one

1

0

4

@PerceptronMD

Robert Chen MD PhD

2 years

Interesting. Any one else doing language model for TCR? Howard’s paper here:

Tweet card media

TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-xbinding analyses

The T-cell receptor (TCR) allows T-cells to recognize and respond to antigens presented by infected and diseased cells. However, due to TCRs’ staggering diversity and the complex binding dynamics...

www.biorxiv.org

@Jens_Luebeck

Jens Luebeck

2 years

#recomb2022 @HowardYChang gave a phenomenal keynote on #ecDNA , and also their lab's work on improving CAR-T. Important audience question - are analyses in cancer which ignore ecDNA status flawed? HYC: Understanding the cancer genome on a linear reference can be very misleading!

Tweet media one

0

4

28

0

0

3

@PerceptronMD

Robert Chen MD PhD

4 months

@Vote_ForPedro @BiggestComeback @lindy_lou_j @MarkBski @Kenharrison99 Day 5: Side plank hip abduction 3x10 Quadruped hip extension kick 3x10 Weighted ankle extension 3xhold to failure Hamstring curl 3x10 Hip thrust 25lb x 2x10 💪

1

0

3

@PerceptronMD

Robert Chen MD PhD

5 months

@Vote_ForPedro @BiggestComeback Bench press x5x3 Dumbbell row x12x3 Leg extension x10x3 Side lying hip adduction x10x3 Prone leg extension x10x3 💪 Strength declines by 1-4% per year once you're an adult. Load it or lose it! @Vote_ForPedro @BiggestComeback

2

0

3

@PerceptronMD

Robert Chen MD PhD

2 years

@AnthonyLeeZhang It's actually not stupid...its something people do... FOMO 3D in 2018:

A $9 Million (and Growing) Pot of Cryptocurrency Is Up for Grabs—Maybe

Is Fomo3D an incisive critique of cryptocurrency culture, a scam, or a little of both?

0

1

4

@PerceptronMD

Robert Chen MD PhD

7 months

VO2max isn’t just some fitness metric. It’s also largely a pissing contest. 1. A big part of it is genetic. Some non-elderly adults are blessed with VO2max over 50 without having to exercise. 2. In the setting of endurance sports, parameters like lactate threshold matter more.

@louisanicola_

LOUISA NICOLA

7 months

VO2 max isn't just some fitness metric. It's the ultimate test of your mitochondrial efficiency. It's oxygen's journey. Energy's birth. Not just endurance. Cellular horsepower. Your body's engine, tested.

23

32

256

1

0

4

@PerceptronMD

Robert Chen MD PhD

4 years

@DGlaucomflecken @whattheslark You should also get your TSH and HIV. And a confirmatory syphilis test when the RPR is positive.

1

0

4

@PerceptronMD

Robert Chen MD PhD

9 months

@rikrenard This is @flatironhealth , @ConcertAI etc except they don’t make $5B a year

0

0

3

@PerceptronMD

Robert Chen MD PhD

2 years

@sbABetterLeader @rsmitty109 @nardinderias No. It’s more like they “pay it forward”. I suffered so you do too.

0

0

2

@PerceptronMD

Robert Chen MD PhD

2 years

1/ This week in cancer Federated learning approach to molecular characterization from histology @jnkath @UniversityLeeds

1

0

4

@PerceptronMD

Robert Chen MD PhD

5 months

@IAmClintMurphy @zachpogrob @erwanlier Millions of people across the globe already "hybrid" train. They just don't run races and don't have a social media following...

0

0

2

@PerceptronMD

Robert Chen MD PhD

5 months

👀 seems like there are more biotech founders taking rapamycin than biotech founders doing triathlons 🤔

@eperlste

Ethan Perlstein bio/acc

5 months

Meeting more and more biotech founders in their 30s and 40s who are taking low-dose rapamycin.

21

6

63

0

1

4

@PerceptronMD

Robert Chen MD PhD

5 months

One of the better conceptualizations of an epigenetic clock out there. If you want to use CpG sites, a reasonable assumption is that stochastic changes constantly happen and over great enough time lapse, a pattern accumulates.

@schumacherbj

Björn Schumacher

5 months

🔥🔥🔥my 💯 paper is out, congrats 🎈🎉🍾 @Meyer_DH for this amazing story. Aging clocks tick by the noise: we can build aging clocks 🕰️ on accumulating stochastic variation! @CECAD_ @UniCologne @CGA_age @UKKoeln follow 🧵retweet & read now open access:

42

95

350

0

2

3

@PerceptronMD

Robert Chen MD PhD

4 months

@Vote_ForPedro @lindy_lou_j @BiggestComeback 💪💪💪💪💪

0

0

3

@PerceptronMD

Robert Chen MD PhD

8 months

@drscottyk @MdWeyhrauch Zone 2 pace, LT1, etc..VO2max is fun to compare against other people but in everyday life you don’t need to sprint at max effort. For anaerobic activities like getting out of a chair, saving yourself from a fall, strength/power assessed by squats/Olympic lifts are more relevant.

1

0

2

@PerceptronMD

Robert Chen MD PhD

3 years

@allisonoconn Article was written from perspective of the classic goal-directed MD/PhD. Many take the scenic route because they genuinely have other personal interests, not because they are “not good” @vineettiruvadi @aaronmrosado @dwhittingslow @EmoryMSTP

1

0

3

@PerceptronMD

Robert Chen MD PhD

3 years

@vineettiruvadi @nplareau Life scientists are non-traditional coders. It’s easier to grock 1-d/2-d tensors than linked lists, heaps, etc.

0

0

3

@PerceptronMD

Robert Chen MD PhD

4 months

@VPrasadMDMPH Once had an attending colleague give unsolicited "advice": "bruh, I published 150 papers in my residency. You have to get that shit published once you have a MPU- minimum publishable unit!" Imagine if that enthusiasm was directed at bigger problems

0

0

2

@PerceptronMD

Robert Chen MD PhD

3 years

@chrissyfarr All of the above. Additionally, email notifications for select colleagues new publications. Unclear how the news feed is populated and personalized to the user- was probably manually curated in the early days @ng

0

0

2

@PerceptronMD

Robert Chen MD PhD

6 months

@jason_ryanmd Intern/resident evals always count for 20-40% of your total eval grade and interns/residents are more likely to grade you higher if you get along with them (carry yourself like them). You can mimic the "good aspects" only and still fit in.

0

0

0

@PerceptronMD

Robert Chen MD PhD

3 years

Deep learning CNN algorithm for identifying HER2 antigen target #machinelearning #AI #oncology #surgery #cancer #pathology

Tweet media one

0

1

3

@PerceptronMD

Robert Chen MD PhD

4 months

RX: 1. Lift Stuff 2. Continue to Lift Stuff

@Vote_ForPedro

Pedro Teixeira MD PhD

4 months

RX: Lift Stuff

Tweet media one

0

1

13

0

0

3

@PerceptronMD

Robert Chen MD PhD

4 months

@DrDeepMD @slotkinjr @digitald0ctor @WillManidis @B_Holmer Good area for evidence based research, especially with anecdotal evidence being biased towards the positive side on social media.

0

0

3

@PerceptronMD

Robert Chen MD PhD

5 months

@gregmushen @DrDeepMD @rebelhealth_ I feel like putting all the puzzle pieces together yourself is fine for young already-healthy fitness freaks (the people that arguably don’t need all these services). A one-stop shop is better for a lazy/illiterate/chronically ill person.

2

0

2

@PerceptronMD

Robert Chen MD PhD

8 months

@MichaelAlbertMD Would take a long time and red tape to assess in a traditional medical research environment. Good use case @DeSciNYC @0xMikeyF @MaxUnfried

0

0

1

@PerceptronMD

Robert Chen MD PhD

5 months

You may scoff at the $40k/year gym-medspa-LabCorp membership but just a reminder that some American longevity practices charge you millions to be a patient only to get you the same “you need to do more deadlifts and pedal harder on your bike” spiel every month

@DrDeepMD

Sandeep Palakodeti, MD MPH

5 months

Equinox gym launches $40k / year gym membership… - Gym access - Quarterly labs - Strength and conditioning coach - Nutrition counseling - Sleep coaching OR @rebelhealth_ - Labs, DEXA, genetics, VO2max, CAC/CCTA - Strength and conditioning coach - Nutrition counseling -

3

4

23

1

0

3

@PerceptronMD

Robert Chen MD PhD

2 years

Video games are not always beatable with reinforcement learning.

@zhusu

朱溯 🐂 (3/AC)

2 years

My thoughts on video games vs touch grass (and I don't think it's a binary thing necessarily) Lots of games today are too simple and easy They're focused on giving you the illusion of control and the illusion of progress. As long as you put in time and or money, you'll improve

63

24

265

0

1

3

@PerceptronMD

Robert Chen MD PhD

5 months

👀 every angry post-op patient

@DavidBroderDO

David Broder, DO

5 months

Is this diet right for you? ▫ No calories, carbs, fats, or cholesterol ▫ No sodium, gluten, or allergens ▫ No ultra-processed foods ▫ Vegan, Kosher and Halal

4

2

8

0

0

3

@PerceptronMD

Robert Chen MD PhD

2 years

@patricksmalone Great advice. Would offer the exact same to anyone wishing for a fulfilling career as a physician-scientist. Maybe it’s harder to see as a student/trainee; communication, domain expertise, personal network, etc all are just as helpful in science vs business.

0

0

3

@PerceptronMD

Robert Chen MD PhD

8 months

@thesamparr @BioLayne Perhaps these studies aren’t counting weighted stretches, dynamic warmups, scaled movements, etc as “stretching”. You’re not going to slap on 645 and rip it. You’re going to do 45, 95, 135, 185, 225, etc… thats obviously better than “stretching” before attempting 645.

1

0

3

@PerceptronMD

Robert Chen MD PhD

4 years

@Jonny_Qi @QwQiao You can say this about many lines of work, not just crypto. But it’s more obvious as the time to ROI is faster.

0

0

3

@PerceptronMD

Robert Chen MD PhD

5 months

Literally any disease is influenced by immunology, not just classic things that come to mind like MS, RA, hashimotos, etc. In order to stave off aging related morbidities, suboptimal immune function is what fundamentally needs to be addressed. This is a dynamical systems problem.

@EricTopol

Eric Topol

5 months

If there's a path to slowing the human aging process, it's likely to involve the immune system new feature @Nature

Tweet media one

17

241

880

2

0

3

@PerceptronMD

Robert Chen MD PhD

4 months

Day 8: Rehab Weighted knee extension x3x10 Glute bridge x3x10 Prone leg extension x3x10 Stationary bike 45 min RPE 1-3 @Vote_ForPedro

2

0

1

@PerceptronMD

Robert Chen MD PhD

4 years

@chrissyfarr The type of consulting that molecular labs do with primary team for treatment recommendations (e.g. PD-L1 positive tumor / keytruda/opdivo) isn’t scalable to the point where entire universe of drugs can be supported. A data-driven solution eg in the EHR is what is needed.

0

0

3

@PerceptronMD

Robert Chen MD PhD

4 years

@aribindi @cchildersmd Yes, the patients love being woken up at 6:30am and then woken up again at 9am to be asked the same questions with 6 other people in the room staring at them.

0

0

3

@PerceptronMD

Robert Chen MD PhD

3 years

Surgery clerkship advice: Don’t cut nerves or vessels with names. You know, like the sciatic, recurrent laryngeal, great saphenous,… #medtwitter #meded #doubledocs

0

1

3

@PerceptronMD

Robert Chen MD PhD

9 months

Reminder - mutational effect changes over time, generations

@zakkohane

Isaac Kohane

9 months

Effect of mutations varies widely over a span of 50,000 generations. Some beneficial become harmful and vice versa but not at equal rates. @baym ™harvardDBMI et al. @scienceMagazine take the long view and dissect complex dialect of evolution.

Tweet media one

1

8

12

0

1

3

@PerceptronMD

Robert Chen MD PhD

2 years

@AlejandroPiad Good chunk of self-taught “data scientists” especially those that majored in biology/economics/etc don’t quite use functions anyway

0

0

3

@PerceptronMD

Robert Chen MD PhD

4 years

Many epidemiologists and outcomes researchers use #R

@affineincontrol

vrtr

@affineincontrol

4 years

All #emr should be required to have #python APIs

0

1

4

0

0

3

@PerceptronMD

Robert Chen MD PhD

5 months

@SsJankauskas @EricTopol Somebody had to say it. Epidemiology shouldn't be as simple as plug and chug in R, even though it's practiced that way.

2

0

3

@PerceptronMD

Robert Chen MD PhD

2 years

@SarahBrnich @nytimes 💪🏼 @EmoryMSTP @bejansaeedi @BrianPedroMDPhD @pathbro @ariellevaldez @skyarmo @YM_Chang @DrBuglove @dwhittingslow

0

0

3

@PerceptronMD

Robert Chen MD PhD

2 years

@biogerontology For any technical subject (e.g. biochemistry, medicine), it will be like this. @Vote_ForPedro

1

0

3

@PerceptronMD

Robert Chen MD PhD

4 years

@vineettiruvadi @ericjames_phd Or perhaps it’s an accurate description and Eric is an outlier. I do think that a lot of the experience in working on tough problems during a PhD can’t really be replicated later in ones career and pumping out quick easy papers diverts one away from that experience.

0

0

3

@PerceptronMD

Robert Chen MD PhD

2 years

Great usage of lab results - pancreatic cancer. Still amazed how little these two communities talk to each other. Cancer researchers still take a genetics/omics-first approach. With clinical (internal medicine/peds, mostly) informaticists taking EHR-first approach.

@proftatonetti

Nicholas Tatonetti

2 years

Clinical lab test results are a *huge* untapped resource for data mining in #EHR research... in some of our latest work (collab with Chin Hur), Dr. Park puts them to good use for early detection of pancreatic cancer. Out now in @JBI_Journal ! 👀

Tweet media one

1

3

28

1

0

2

@PerceptronMD

Robert Chen MD PhD

6 months

@AbudBakri It's the doctors job to emphasize to them why they should make such choices and to point them in the right direction. A doctor should be quarterbacking the patient's care. That's what separates a doctor from a nurse/dietitian/athletic trainer/etc.

2

0

2

@PerceptronMD

Robert Chen MD PhD

5 months

@drscottyk @DrSiyabMD I wish more people would adopt this mindset. It's noninvasive and easy. If you're savvy enough as a patient, you can probably ultrasound yourself with a butterfly/lumify etc and upload the image to some AI service online and have it give you a score for % occlusion,..

1

1

3

@PerceptronMD

Robert Chen MD PhD

4 months

@Vote_ForPedro @BiggestComeback Day 22 Nothing x24 hrs See you tomorrow 😊 @lindy_lou_j @MarkBski

0

0

3

@PerceptronMD

Robert Chen MD PhD

6 months

Walking IS exercise. If you're out of shape, walking puts you in "zone 2". But if you're IN shape, you get more bang for your buck moving at higher intensity. There is no upper limit to longevity benefits from maximizing cardiorespiratory fitness.

@DrSiyabMD

Siyab Panhwar, MD

6 months

TikTok fitness influencer/podcasters are saying that walking is not exercise. Y’all these fitness influencer/Podcasters are not OK. Someone please go check on them. Just because somebody has a fancy podcast on TikTok or Twitter or Instagram doesn’t mean that they know what

21

20

192

0

0

3

@PerceptronMD

Robert Chen MD PhD

5 months

@FitFounder @BowTiedRunning This is why for the majority of people, lifting weights is an easier way to move towards their desired body composition. If you have to work 3 jobs to put food on the table for you and your 3 kids, you can't sit on your bike for 4 hours a day.

0

0

1

@PerceptronMD

Robert Chen MD PhD

3 years

@allisonoconn @hkeetz Very nice when someone’s first reaction isn’t “why the **** would you want to work those hours?”

1

0

3

@PerceptronMD

Robert Chen MD PhD

6 months

LDLc causes atherosclerosis. “Lean mass hyperresponder ketogenic eaters”are statistical outliers and should not be used as role models for patients.

@MichaelAlbertMD

Michael "Mike" Albert, MD

@MichaelAlbertMD

6 months

I wish I had the courage to hold statins in CAC=0 but sufficiently risked populations. Unfortunately, I hold RCTs with annoying endpoints like ACM and CV death in higher regard than observational CAC studies. Guess I’m a shill for BIG EVIDENCE. 🤷🏼‍♂️ @DrNadolsky @drpablocorral

12

4

57

0

1

2

@PerceptronMD

Robert Chen MD PhD

3 years

@markkitti @vineettiruvadi @nplareau I’m with Vineet on this one. Python is better for a variety of reasons. But regarding cost, you *could* say sure there’s Octave...

0

0

2

@PerceptronMD

Robert Chen MD PhD

6 months

many epidemiology studies use "time served ln physical activity" as the independent variable against morbidity but functional status/performance is really what the variable should be. They are correlated but not perfectly so.

Tweet card media

With exercise, results matter more than “time served”

How much time should a person spend exercising? However long it takes to see meaningful improvements in VO2 max and strength

peterattiamd.com

0

0

2

@PerceptronMD

Robert Chen MD PhD

3 years

@vineettiruvadi @nplareau Python is preferred by traditional coders (those that code to build software) MATLAB is preferred by non-traditional coders (those that code to make discoveries and don’t have a formal computer science education)

1

0

3

@PerceptronMD

Robert Chen MD PhD

3 years

@Sanjusinha7 @tangming2005 Glioblastoma scRNA seq:

1

0

3

@PerceptronMD

Robert Chen MD PhD

6 months

Overlooked by healthcare professionals: Endurance sports are EXPENSIVE. Not because you need fancy equipment. You can't sit on your bike for 20 hours/week if you're in debt, have a family to feed, or have a gun pointed at your head in the high crime neighborhood you live in.

1

0

3

@PerceptronMD

Robert Chen MD PhD

4 months

@Vote_ForPedro Comprehensive workout!

1

0

2

@PerceptronMD

Robert Chen MD PhD

4 months

Day 11: Leg press x3x10 Banded lateral walk x3x10m Seated leg lift x3x8 Banded slant board squat x3x8 Banded lunge x3x10

1

0

2

@PerceptronMD

Robert Chen MD PhD

6 months

Great opportunity to be one of the first to build the transparent "Airtable for science".

@0xMikeyF

Dr. Michael

6 months

Doubling down on #DeSci . Hiring a few more software engineers. 200k / year. Ideally in person in NYC. Send me a short DM with what excites you about DeSci to get the ball rolling. Stay curious.

3

9

38

0

1

2

@PerceptronMD

Robert Chen MD PhD

1 month

🙃

@0xMikeyF

Dr. Michael

1 month

Does anyone know how to white label an Oura ring type device? Or white label any wearable?

3

0

10

1

0

2

@PerceptronMD

Robert Chen MD PhD

7 months

@scottcarlinpt Also, don’t obsess over hitting 180 cadence at 8min/km pace…Forcing a square peg to a round hole

1

0

2