Marco Leitzke @LeitzkeMarco Twitter profile

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Marco Leitzke

@LeitzkeMarco

1 year

@RSandra266 @oliver_beldi @__Acc_Deleted__ Absolut. Wir planen derzeit für Ende diesen Monats eine n=1 Bildgebungsstudie, bei der auch der SPG Verlauf unter Nikotingabe bewertet werden soll.

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Marco Leitzke

@LeitzkeMarco

7 months

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Marco Leitzke

@LeitzkeMarco

1 year

Marco Leitzke - Behandlung von long covid und ME CFS mit Nikotin...

WICHTIGER HINWEIS:Bei Bedenken zu Vorerkrankungen oder Wechselwirkungen mit Medikamenten, ist es zu empfehlen mit deinem Hausarzt zu sprechen. In dieser beei...

www.youtube.com

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Marco Leitzke

@LeitzkeMarco

1 year

@mrartimisfoley @TheNicotineTest @Really_Richelle @tessfalor @cobba27 @simuellers Cholinergic neurotransmission is describable as the effectiveness of energy transmission within your body. It regulates the energy consumption of each cell of you body. If cholinergic neurotransmission is blocked, even partly, (nAChRs), effectiveness breaks down.

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Marco Leitzke

@LeitzkeMarco

1 year

@ourcarly @Canal1point5 @acjuelich @petri_pellinen @TMaritanoAquino @danaparish We saw several ME/CFS suffers with clear improvement. After such a long period of misery we still must find out how long nicotine application is necessary. My belief is, that after 4 weeks one should judge the situation anew.

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Marco Leitzke

@LeitzkeMarco

1 year

@mmeclouseau81 @Clautoffel Mastzellen sind in ihrer Histaminproduktion durch hemmende nikotinerge Azetylcholinrezeptoren reguliert. Aus der Blockade der nAChRs erklärt sich die unregulierte Freisetzung von Histamin (MCAS). Das Pflaster sollte also das MCAS eher bessern als provozieren.

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Marco Leitzke

@LeitzkeMarco

1 year

@_waldmeer_ @RSandra266 Beim Inhalieren von Zigarettenrauch entstehen 80fach höhere Konzentrationen von Nikotin im Vergleich zum Pflaster. Das setzt Dopamin frei, welches die Sucht macht. Pflaster decken den Nikotinhunger, setzen aber kein Dopamin frei = Sucht ausgetrickst

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Marco Leitzke

@LeitzkeMarco

1 year

@NickChambers2 What a message. Thank you Nick! Now I am sure, We‘re going to win the fight!!!

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Marco Leitzke

@LeitzkeMarco

1 year

@TheNicotineTest @Really_Richelle @tessfalor @petri_pellinen Vomiting and diarrhoea are classical side effects of nicotine and may be taken as a sign, that nicotine started its job pushing out the viral residuals.

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Marco Leitzke

@LeitzkeMarco

1 year

@TheNicotineTest Thanks for you immense effort

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Marco Leitzke

@LeitzkeMarco

1 year

@TheNicotineTest We are preparing such a study

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Marco Leitzke

@LeitzkeMarco

1 year

@EisenkraftFam @useless_priest The theory is that nicotinic acetylcholine receptors all over your body are blocked by SARS-CoV-2 impairing severely the communication between your cells. This is the pathological basis of LC.

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Marco Leitzke

@LeitzkeMarco

1 year

@RSandra266 Nein, 3-5 Tage reichen

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Marco Leitzke

@LeitzkeMarco

1 year

@candlelovers12 @TheNicotineTest @Canal1point5 It is called „herx“, feels like a flu and is due to the released virus particles, which are erased by your immune system beginning day 4 or 5

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Marco Leitzke

@LeitzkeMarco

1 year

@Canal1point5 @TheNicotineTest @jasonmparsons @IamTeriC @tfouto @peakstopac @AnciraBecky @TMaritanoAquino @LongCovidHell It is more likely a logical conclusion. Since, cholinergic neurotransmission (cn) represents the energy effectiveness of human body, athletic performance is far more dependent on cn and this makes athletes more vulnerable to LC. (like a tuned engine)

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Marco Leitzke

@LeitzkeMarco

1 year

@acjuelich @petri_pellinen @TMaritanoAquino @danaparish Since,the great majority of LC sufferers are nicotinnaiv individuals those should start with a partly covered 7.5mg patch an accelerate every second day.When 7.5mg are reached, at least 7 days this dosage.After long term LC better 2 up to 4 interruption

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Marco Leitzke

@LeitzkeMarco

1 year

@internetuserf12 This is definitely not the case. All the money, my study has taken Was my own. I did so, exclusively for the millions of sufferers from LC/ME/CFS, which until now experience no financial, investigational and moral support from any side. My study refers exclusively to patches!

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Marco Leitzke

@LeitzkeMarco

1 year

In the case of a post-vac syndrome the initial worsening is obviously far harder than in PCS/ME/CFS. If somebody with PVS is going to try, please reduce the initial dosage (1/4) and accelerate very slowly.

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Marco Leitzke

@LeitzkeMarco

1 year

If the dosage acceleration takes part in a very protracted manner this might lead to virus liberation in a likewise bit by bit fashion. If this, below the threshold of your immune system’s activation, the initial worsening might take longer than 2 days.

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Marco Leitzke

@LeitzkeMarco

1 year

@EisenkraftFam @useless_priest Since, nicotine has a far higher affinity to these receptors compared to acetylcholine it can extrude the virus from the receptor. Thus the diminished cellular communication is reestablished.

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Marco Leitzke

@LeitzkeMarco

1 year

@Naomi_D_Harvey from the blocked receptors. Along TNT it is not advisable to use both substances, since nicotine + increased AChR might provoke overexcitation to the system. After TNT one of these substances is probably smart to support the healing process.

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Marco Leitzke

@LeitzkeMarco

1 year

@EisenkraftFam @useless_priest The first 2 days could be hard due to the set free virus particles and the physiological reaction time of your immune system. Since, nicotine has a very short halftime continuous application is essential. Otherwise, the virus re occupies the receptors.

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Marco Leitzke

@LeitzkeMarco

1 year

@oliver_beldi @__Acc_Deleted__ @RSandra266 Das stimmt. Ich gehe davon aus, dass diese Spikeproteinzirkulation unter der immunologischen Schwelle liegt. Wie die herx reaction zeigt/vermuten lässt, wird diese Schwelle bei Nikotinapplikation überschritten und eine immunologische Beseitigung des SGP ermöglicht.

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Marco Leitzke

@LeitzkeMarco

1 year

@Brendabrenner11 @ourcarly @Canal1point5 @acjuelich @petri_pellinen @TMaritanoAquino @danaparish The difference between chewing gum and pasting patches is that transdermal nicotine application guarantees constantly low blood levels of the substance. Any other application form is not capable to do so. Interrupted nicotine levels Allow the virus particles to reoccupy the AChRs

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Marco Leitzke

@LeitzkeMarco

1 year

@NickChambers2 @DreamingTheMind @petri_pellinen @DeborahEveniss @Bussin34 @virginie2705 @noemi_landolt @DrDavidClements @The2Margarets @fightinglina @TheSunshineVit1 @TheNicotineTest This terrible experience with success at last is not referable to nicotine as a substance but rather to the set free virus particles due to nicotine action. But it is understandable that the name nicotine itself causes a lot of automatic fears

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Marco Leitzke

@LeitzkeMarco

1 year

@NickChambers2 @CortJohnson

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Marco Leitzke

@LeitzkeMarco

1 year

@_trans4m8tion I myself did so (successfully). But, of course ther is no scientific proof yet.

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Marco Leitzke

@LeitzkeMarco

1 year

@IamTeriC @tfouto @peakstopac @TheNicotineTest @jasonmparsons @AnciraBecky @TMaritanoAquino @LongCovidHell The longer the virus is in our body, the deeper it can penetrate. Theoretically, at almost every cell of nAChRs can be blocked.with each release into the bloodstream (nicotine) so with each infection-like scene, the viruses are reduced in number by the immune system.

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Marco Leitzke

@LeitzkeMarco

1 year

Because nicotine has up to 30-fold higher affinity for nAChRs than the natural ligand (acetylcholine), transcutaneous nicotine application is a promising candidate to control the post COVID tragedy.

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Marco Leitzke

@LeitzkeMarco

1 year

@TheNicotineTest @jasonmparsons @IamTeriC @tfouto @peakstopac @AnciraBecky @TMaritanoAquino @LongCovidHell Cholinergic Neurotransmission plays a far higher role in athletes.

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Marco Leitzke

@LeitzkeMarco

1 year

@Gmwetz I case of good tolerance dosage acceleration (after the first week) might enhance effectiveness

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Marco Leitzke

@LeitzkeMarco

1 year

@peakstopac @DYork1979 Palpitations are very common to nicotine usage and they feel really bad. To wait with dosage acceleration until they get better is a smart option

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Marco Leitzke

@LeitzkeMarco

1 year

@angryhacademic They tested just 1 receptor (alpha7nAChR). Altogether, we know 16 different nAChRs

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Marco Leitzke

@LeitzkeMarco

1 year

@momof2andahalf Ich würde der immunologischen Antwort Ihres Körpers Raum geben. Antiviral Substanzen sind alles Andere als nebenwirkungsfrei.

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Marco Leitzke

@LeitzkeMarco

1 year

Dr Marco Leitzke DESA | Twitter, Instagram, Facebook | Linktree

senior physician // anaesthetist // researcher

linktr.ee

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Marco Leitzke

@LeitzkeMarco

1 year

@Bhakti_Purple @petri_pellinen The immune system erases the virus by antibodies.

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Marco Leitzke

@LeitzkeMarco

1 year

@TheNicotineTest Both substances should be avoided along #TheNicotineTest whilst patch pasting. During the recovery phase (without nicotine patches) they may offer beneficial support to healing

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Marco Leitzke

@LeitzkeMarco

1 year

@peakstopac @tfouto @IamTeriC @TheNicotineTest @jasonmparsons @AnciraBecky @TMaritanoAquino @LongCovidHell But he was in the earliest stage of LC

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Marco Leitzke

@LeitzkeMarco

1 year

@probablyautist @ourcarly Cholinergic agents are principally the right direction. Since, pure acetylcholine cannot displace the virus, these agents are of minimal effect before nicotine. Along nicotine they are ‚twice salt in the soup‘. After nicotine they are very good support. (opinion)

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Marco Leitzke

@LeitzkeMarco

1 year

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Marco Leitzke

@LeitzkeMarco

1 year

@jungleswatcher @TheNicotineTest @petri_pellinen You‘ve got me wrong. nAChRs counteract clotting. Their blockade promotes hyperclotting. The release of SARS-CoV-2 from nAChRs results in fixing this problem. Therefore, nicotine should be the solution, not the problem. (understandable?)

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Marco Leitzke

@LeitzkeMarco

1 year

@mmeclouseau81 @Clautoffel Im Übrigen haben wir mittlerweile bei vielen neu aufgetretenen Nahrungsmittelunverträglichkeiten tolle Verläufe gesehen. Viel konnten wieder alles essen. Fazit: 3,5mg, wenn anfangs gut vertragen, weiter. Manchmal sind herx, Nikotinnebenwirkung und MCAS schwer zu unterscheiden.

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Marco Leitzke

@LeitzkeMarco

1 year

@TheNicotineTest @illness_almanac Actually, HBOT does not improve perfusion but oxygen supply due to increased partial pressure of oxygen in the blood. This means, despite bad perfusion due to microclots the oxygen supply increases because the blood carries far more oxygen than normal.

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Marco Leitzke

@LeitzkeMarco

1 year

@noralove @Canal1point5 @Fatigo_MECFS Please, not the neck. Your inner ear is an extremely good perfused region.Transdermal nicotine from wherever is going to reach them.Within your neck one finds a plethora of extremely sensitive structures influenceable by nicotine, which might lead to very central reactions.

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Marco Leitzke

@LeitzkeMarco

1 year

@fighting_MECFS @DrChronically

Dr. Marco Leitzke (@marcoleitzke) • Instagram reel

www.instagram.com

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Marco Leitzke

@LeitzkeMarco

1 year

@Canal1point5 Imagine, some (or a lot) of the myofribrilles of each muscles are blocked: earlier anaerobic activity => lactate generation, weakness no need to explain, organism tries to compensate this with elevating acetylcholine (limited capacity to do so) => PEM after any action above this

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Marco Leitzke

@LeitzkeMarco

1 year

@kirahagen Partial taping of the nicotine patch could be a good alternative to cutting the patch in terms of dose reduction.

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Marco Leitzke

@LeitzkeMarco

1 year

@Canal1point5 @Andriarose61 @petri_pellinen @Fatigo_MECFS @PeterAttiaMD @kirahagen In cases of diarrhoea activated charcoal is a smart option. The elimination of spike protein is more likely the task of the immune system.

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Marco Leitzke

@LeitzkeMarco

1 year

@jannamoen Great. Let’s start!

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Marco Leitzke

@LeitzkeMarco

1 year

Dr Marco Leitzke DESA | Twitter, Instagram, Facebook | Linktree

senior physician // anaesthetist // researcher

linktr.ee

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Marco Leitzke

@LeitzkeMarco

1 year

@TylerPaulP @petri_pellinen In some cases it took more than 4 weeks of pasting patches

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Marco Leitzke

@LeitzkeMarco

1 year

@PaulineKevin5 @TheNicotineTest ACE2 receptors are used by the virus to enter the cell along acute infection. After cell entry,those receptors are given free, because the actual target of the virus is host dna to replicate. nAChRs are blocked in chronic courses,where ACE2 receptors play not a prominent role

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Marco Leitzke

@LeitzkeMarco

1 year

@jannamoen I recently published a hypothesis paper concerning acute COVID-29 infection targeting alpha7nAChRs

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Marco Leitzke

@LeitzkeMarco

1 year

@IamTeriC @tfouto @peakstopac @TheNicotineTest @jasonmparsons @AnciraBecky @TMaritanoAquino @LongCovidHell This is primarily because SARS-COV-2 replicates in the pharynx and respiratory tract, where a great deal of a cleavage enzyme (TMPRSS2) is present that prepares the spike protein for coupling to ACE2 in such a way that it can enter the cell 100-fold faster.

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Marco Leitzke

@LeitzkeMarco

1 year

@leap_ryan @BrendaBrenner3 @NickChambers2 @CortJohnson You should take more time to judge your successes. In such a long lasting illness, it is advisable to consider more rounds (7 days) with strict interruptions (7days as well). We saw ME/CFS sufferers definitely improving after 4 rounds

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Marco Leitzke

@LeitzkeMarco

1 year

@KellyJean72 @TMaritanoAquino @kirahagen 3-4 weeks have crystallised to be a sufficient Intervall after longtime LC

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Marco Leitzke

@LeitzkeMarco

1 year

@TMaritanoAquino @Brendabrenner11 @ourcarly @Canal1point5 @acjuelich @petri_pellinen @danaparish Nicotinic acetylcholine receptors (alpha7nAChRs are responsible for regulation of cytokine (pro-inflammatory transmitters) thereby involved in how severe acute COVID appears. Therefore chronic stimulation of those receptors (smoking) has shown far less ICU and severe courses.

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Marco Leitzke

@LeitzkeMarco

1 year

@Andriarose61 @NickChambers2 @DreamingTheMind @petri_pellinen @DeborahEveniss @Bussin34 @virginie2705 @noemi_landolt @DrDavidClements @The2Margarets @fightinglina @TheSunshineVit1 @TheNicotineTest Gum does not work with comparable effectiveness and might be counterproductive

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Marco Leitzke

@LeitzkeMarco

1 year

@NickChambers2 Incredible, even to me🥳

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Marco Leitzke

@LeitzkeMarco

1 year

@_trans4m8tion @TMaritanoAquino @rasxchelo Antihistamines are absolutely not counterproductive. Keep the inhalers to feel safe. Mastcell activation is likewise controlled by acetylcholine receptors and their blockade is a reasonable explanation for MACS.

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Marco Leitzke

@LeitzkeMarco

1 year

@RachelCOSG @peakstopac @TheNicotineTest @remissionbiome @probablyautist @kirahagen @petri_pellinen nAChRs change between 3 functional states: 1. unstimulated and sensitive 2. stimulated and sensitive 3. unstimulated and desensitised. 3 can be evoked by long term low dose stimulation. The question what is long term and what is low dose is to be answered very individually.

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Marco Leitzke

@LeitzkeMarco

1 year

@ClausErnst @PuzzleOfHealing 🙏🏽

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Marco Leitzke

@LeitzkeMarco

1 year

@IamTeriC @tfouto @peakstopac @TheNicotineTest @jasonmparsons @AnciraBecky @TMaritanoAquino @LongCovidHell Because this enzyme is not present in the blood to the same extent, the viruses also do not multiply there to the same extent as they do in the throat or lungs, theoretically there is also no relevant multiplication and we do not see any real reinfection.

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Marco Leitzke

@LeitzkeMarco

11 months

@Gmwetz @realfrankbecker Von unseren 10 Billionen Körperzellen kann theoretisch jede betroffen sein, so dass, je nachdem wo das Nikotin andockt, nicht gleich alle betroffenen Zellen Nikotin „abbekommen“.

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Marco Leitzke

@LeitzkeMarco

1 year

@RachelCOSG @peakstopac @TheNicotineTest @remissionbiome @probablyautist @kirahagen @petri_pellinen After an interruption 3 changes back into 1. Each must find out, when is the optimal time to make an interruption. Best if you feel a lowering effectiveness after improvement along pasting patches.

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Marco Leitzke

@LeitzkeMarco

1 year

@LenaLenaLund @petri_pellinen Almost perfect. Nicotines binds and kicks off the virus. After binding it stimulates what the virus did not. Then it breaks down due to its short halftime. Thus, the way is paved for physiological stumbling acetylcholine. To be understood?

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Marco Leitzke

@LeitzkeMarco

1 year

@EisenkraftFam @useless_priest The 7 days described in the article have proven to be fairly short. 14 up to 28 days are safer. The patches cannot evoke addiction!

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Marco Leitzke

@LeitzkeMarco

1 year

@jungleswatcher @Canal1point5 @acjuelich @petri_pellinen @TMaritanoAquino @danaparish In this small cohort there was not a case of tinnitus. Since,I am not an ear specialist I won’t promise anything. Nobody reported about worsening along patches. To my understanding tinnitus in smokers is related to inner ear arteriosclerosis, which is not due to nicotine

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Marco Leitzke

@LeitzkeMarco

1 year

@Clautoffel 😊

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Marco Leitzke

@LeitzkeMarco

1 year

@IamTeriC @peakstopac @jasonmparsons @AnciraBecky @TMaritanoAquino @LongCovidHell I couldn’t have said better!

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Marco Leitzke

@LeitzkeMarco

1 year

@peakstopac @TheNicotineTest @remissionbiome @probablyautist @kirahagen @petri_pellinen Truth, but an interruption after about 10 days may be critical for effectiveness

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Marco Leitzke

@LeitzkeMarco

1 year

@illness_almanac @acjuelich @petri_pellinen @TMaritanoAquino @danaparish After such a Long time 7 days are probably far to less. Long term application (>4 weeks) is not dangerous. It is probably useful to end such a long application with a stepwise reduction of the dosage (ever 3rd day reduction)

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Marco Leitzke

@LeitzkeMarco

1 year

@IamTeriC @tfouto @peakstopac @TheNicotineTest @jasonmparsons @AnciraBecky @TMaritanoAquino @LongCovidHell Was that reasonably understandable?

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Marco Leitzke

@LeitzkeMarco

1 year

@RSandra266 @schabelreiter_u 👍🏽

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Marco Leitzke

@LeitzkeMarco

1 year

@buckleydebbie @TheNicotineTest You must differentiate between autoantibodies and SARS-CoV-2 related receptor blockade. Autoantibodies can appear to any target within your body along LC

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Marco Leitzke

@LeitzkeMarco

1 year

@TMaritanoAquino @illness_almanac @acjuelich @petri_pellinen @danaparish Guess, it is worth a trial

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Marco Leitzke

@LeitzkeMarco

1 year

@TheMurfDawg @TheNicotineTest @Canal1point5 I think it is better to await the bypassing fluvax reaction of you body, before starting nicotine. So, in best case you could start 3 day before C booster.

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Marco Leitzke

@LeitzkeMarco

8 months

@Spiritoftheoce1 @NinurtaDoc

Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation...

Following a SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with common everyday activities due to weakness, memory lapses, pain, dyspnea...

bioelecmed.biomedcentral.com

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Marco Leitzke

@LeitzkeMarco

1 year

@TheNicotineTest @petri_pellinen The microclots lead to hypoxic metabolism in the perfusion areas after clot-occlusion. This metabolism without oxygen produces lactate.

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Marco Leitzke

@LeitzkeMarco

1 year

@LenaLenaLund @petri_pellinen Guess so. It is not proven. But ME/CSF is more and more referred to prior virus infections. Meanwhile, some ME/CFS sufferers experienced clear improvement after nicotine.

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Marco Leitzke

@LeitzkeMarco

1 year

@KristinaRevay @TheNicotineTest @kiss_my_kumquat @candlelovers12 @Canal1point5 This conclusion, unfortunately, was a bit to short, since cholinergic neurotransmission is an extremely individual property of each organism, influenced by a huge, partly undeciphered, factors. I am afraid, there is no real alternative to individual dosage finding.

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Marco Leitzke

@LeitzkeMarco

1 year

@akkadtr1 @TheNicotineTest @tessfalor @remissionbiome @patientled The released virus particles evoke an inflammation-like situation, which is experienced as „herx “. The sufficient immunological reaction of the organism takes its time. Since,nicotine releases the virus particles bit by bit, this situation is difficult to predict conc. endurance

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Marco Leitzke

@LeitzkeMarco

1 year

@sarahga89137569 @TheNicotineTest To my opinion pasting patches along acute infections is not an issue and might even ameliorate them. I pasted patches to my father along his severe acute COVID-19 infection at our ICU and I am convinced (even if not provable) that this prevented him from ventilator treatment.

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Marco Leitzke

@LeitzkeMarco

1 year

@DanDraitser @TheNicotineTest @MrTheposter Not cutting but partly covering (pic). Cutting can lead to uncontrolled nicotine distribution

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Marco Leitzke

@LeitzkeMarco

1 year

@Big_Appel @ClausErnst @PuzzleOfHealing Nope.Rauchen erhöht die Blutspiegel von Nikotin in Sekunden auf exorbitante Werte, die genau so schnell wieder abfallen. Das erricht die Rezeptoren nicht nur nicht alle, sondern wird der Rezeptordynamik/-konformation nicht gerecht. Außerdem generiert Rauchen Sucht, Pflaster nicht

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Marco Leitzke

@LeitzkeMarco

1 year

@MaryandBessie @GillelandKristi The mentioned receptors realise communication between all the cells in our body. SARS-CoV2 blocks these receptors leading to all the symptoms of LC after the acute phase of COVID. Transcutaneous nicotine can extrude the virus. The set free virus is eliminated by our immune system

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Marco Leitzke

@LeitzkeMarco

1 year

@NickChambers2 @CiaraGlenville Hi Nick, I think that this is absolutely possible. To provide a safety short nicotine patch intervention might be a very good bridge before permanent improvement, which could take time in the individual case. This, especially, since we saw cases with a rather prolonged response.

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Marco Leitzke

@LeitzkeMarco

1 year

@RSandra266 Auch die Klebephasen sind hinsichtlich der Dauer eher variabel

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Marco Leitzke

@LeitzkeMarco

1 year

@007_siegel There are currently 3 youngsters (~12 years) under reduced dosage and daily feedback to me under nicotine patch pasting. We need a little more time to see how they do

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Marco Leitzke

@LeitzkeMarco

1 year

@PaulRKeeble @theedifyingword 👍🏽 patches are fare superior to gums since the theory is made on the basis of constantly low nicotine blood levels until your immune system erased the entire SARS-CoV-2 residuals. Only this protects the acetylcholine receptors from viral re-occupation

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Marco Leitzke

@LeitzkeMarco

11 months

@Gmwetz @realfrankbecker Zudem ist der nAChR allosterisch konfiguriert. Das heißt 5 der 6 AChR Bindungsstellen sind im Normalzustand gar nicht zugänglich. Wenn diese aber blockiert sind, ist der Weg für Nikotin „länger“

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Marco Leitzke

@LeitzkeMarco

1 year

@__Acc_Deleted__ @RSandra266 Die ACE2 Rezeptoren sind ausschließlich für den cell entry bei der Akutinfektion von Bedeutung.

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Marco Leitzke

@LeitzkeMarco

11 months

@KTins8 @TheNicotineTest Ich denke unter „Nikotinschutz“ ist das kein Problem

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Marco Leitzke

@LeitzkeMarco

1 year

@Canal1point5 @angryhacademic @TheNicotineTest @CiaraGlenville @chydorina @Naomi_D_Harvey @mera_cordero Absolutely!

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Marco Leitzke

@LeitzkeMarco

1 year

@_trans4m8tion @__Acc_Deleted__ @RSandra266 Switching off ACE2 reduces the binding sites for the virus substantially. After knock out of ACE2 there are just AChRs for binding of SGP available. AChRs do not directly promote viral infection (indirectly via blocked antiinflammatory alpha7nAChRs), the result are LC symptoms.

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5

Marco Leitzke

@LeitzkeMarco

1 year

@TheNicotineTest @DSKnipp I think, it is rather a question of time of application. Long term low dose agonist application leads to desensitised (1 of 3 functional states) acetylcholine receptors leading to pro-inflammatory action. Therefore, after a while an interruption may be beneficial

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Marco Leitzke

@LeitzkeMarco

1 year

@kirstler31 @Canal1point5 @DominicMoss13 Absolutely. For eliminating residual virus particles you need constantly low blood levels of the substance. This is only guaranteed with patches. Any other application form could even prolong or worsen the symptoms due to very high blood levels disappearing in a very short time.

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Marco Leitzke

@LeitzkeMarco

1 year

@NeuesFuechsle Das freut mich wirklich sehr 👍🏽👍🏽👍🏽

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Marco Leitzke

@LeitzkeMarco

1 year

@KellyJean72 @Ness_longcovid @noralove @petri_pellinen Sea salt acts against hydration, since I accelerates renal filtration. This is probably only one possible factor along the LC hydration problem

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Marco Leitzke

@LeitzkeMarco

1 year

@acjuelich @petri_pellinen @TMaritanoAquino @danaparish The study author I was referring to ( @LeitzkeMarco ) now says that 3-4 weeks has crystallized to be the sufficient length of patch application for long time long haulers. So it may depend on how long you’ve been sick, as well as other variables.

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