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BensenHsu Profile
BensenHsu

@BensenHsu

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2,333
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Founder @OpenRead_HQ | Quantum computing YouTuber

San Francisco
Joined March 2020
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@BensenHsu
BensenHsu
4 months
@HumansNoContext It’s a Chinese word obviously
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@BensenHsu
BensenHsu
3 months
@SamuelBHume The researchers concluded that IL-11 signaling is a key driver of age-related dysfunction and that inhibiting IL-11 can extend both healthspan and lifespan in mice. They propose that the beneficial effects are mediated through IL-11's regulation of critical aging pathways like
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@BensenHsu
BensenHsu
1 month
@emollick The paper presents GameNGen, a neural network-based game engine that can simulate the classic game DOOM in real-time with high visual quality. This is a novel approach compared to traditional game engines, which are manually programmed. The key insights are that diffusion models
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@BensenHsu
BensenHsu
4 months
@alvinfoo Screenless with glasses 🥲
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@BensenHsu
BensenHsu
4 months
@lucas__crespo The computer. Cuz it is not waterproof
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@BensenHsu
BensenHsu
1 month
@AdamMGrant The study aims to find different types or "biotypes" of depression and anxiety disorders based on brain imaging data. Patients with depression and anxiety often have different problems in how their brain circuits work, and the current diagnostic system does not capture this
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@BensenHsu
BensenHsu
2 months
@EricTopol @NatureMedicine The review shows that the Westernization of diet, characterized by increased consumption of processed foods, refined carbohydrates, and unhealthy fats, has contributed to the global rise of chronic diseases. Specific aspects of the Western diet, such as food additives, artificial
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@BensenHsu
BensenHsu
1 month
@EricTopol @Nature @AkassoglouLab @GladstoneInst The study explores the role of fibrinogen, a blood protein that forms clots, in the severe COVID-19 disease. Patients with COVID-19 often have abnormal blood clots that are difficult to break down. The researchers found that the SARS-CoV-2 spike protein binds to fibrinogen,
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@BensenHsu
BensenHsu
4 months
@EricTopol @EricTopol The study proposes a novel murine model that mirrors the pathophysiological mechanisms of Long COVID, which could be used as a tool for screening and developing targeted therapeutics.
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@BensenHsu
BensenHsu
1 month
@vipintukur The researchers wanted to find a new way to stop the SARS-CoV-2 virus, which causes COVID-19, from infecting cells. They looked at a chemical called UNI418 that can block two important enzymes in cells called PIKfyve and PIP5K1C. The researchers found that UNI418 can effectively
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@BensenHsu
BensenHsu
1 month
@quay_dr The study examines how the modification made by Pfizer to the mRNA bases used in its COVID-19 vaccine can lead to errors in the production of spike proteins. This is because the modified mRNA can cause the ribosomes (the cellular machinery that produces proteins) to make mistakes
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@BensenHsu
BensenHsu
2 months
@EricTopol The findings suggest that COVID-19, especially severe disease, can lead to long-lasting cognitive impairment in older adults. However, the cognitive decline seems to be mostly limited to the first year after infection, and in some cases, improvements were seen over time. full
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@BensenHsu
BensenHsu
2 months
@EricTopol @NatureMedicine @MaximeTaquet The researchers found that people who received the recombinant shingles vaccine had a significantly lower risk of developing dementia within 6 years of vaccination compared to those who received the live vaccine. Specifically, the recombinant vaccine was associated with a 17%
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@BensenHsu
BensenHsu
1 month
@slavov_n The paper highlights several key findings that challenge the conventional understanding of biology: • Genes do not have a pre-set function that can be determined from their DNA sequence, and their activity depends on various external factors. • Many proteins have disordered
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@BensenHsu
BensenHsu
1 month
@EricTopol @JAMA_current @shwoolf The study examines the increasing mortality rates in the United States, but not from COVID-19. It focuses on the rising mortality rates from non-COVID causes, which have been a trend even before the pandemic. The study found that while COVID-19 mortality rates have declined,
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@BensenHsu
BensenHsu
1 month
@EricTopol The researchers wanted to understand how the proteins in the blood change as people get older. They analyzed the proteins in the blood of over 4,000 people ranging from young adults to elderly people. The researchers found that the levels of many proteins in the blood changed
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@BensenHsu
BensenHsu
2 months
@EricTopol @NatureAging The findings suggest that a history of certain infections may contribute to an increased risk of dementia by triggering changes in the immune system and the expression of specific proteins that can then impact brain structure and function. The researchers propose that these
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@BensenHsu
BensenHsu
7 days
@EricTopol @Nature The study aimed to understand why the protective antibodies against COVID-19 provided by the mRNA vaccines wane quickly, even though the vaccines can generate COVID-19 specific antibody-producing cells in the bone marrow. The study found that while influenza and tetanus specific
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@BensenHsu
BensenHsu
1 month
@_akhaliq The paper presents GameNGen, a neural network-based game engine that can simulate the classic game DOOM in real-time with high visual quality. This is a novel approach compared to traditional game engines, which are manually programmed. The key insights are that diffusion models
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@BensenHsu
BensenHsu
22 days
@EricTopol This paper discusses lipoprotein(a), which is a type of cholesterol particle in the blood. High levels of lipoprotein(a) can increase the risk of heart disease and other health problems. The key findings include: • High lipoprotein(a) levels are a major risk factor for heart
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@BensenHsu
BensenHsu
2 months
@Nature The researchers ruled out potential experimental artifacts and found that the dark oxygen production was likely linked to the presence of the polymetallic nodules. They hypothesized that the high voltage potentials measured on the nodule surfaces may be driving seawater
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@BensenHsu
BensenHsu
1 month
@EricTopol The researchers aimed to understand how GLP-1 RAs impact different aspects of health in people with obesity over a 5-year period. They wanted to see if these medications could provide benefits beyond just weight loss. The study found that people treated with GLP-1 RAs had
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@BensenHsu
BensenHsu
1 month
@EricTopol @NatureAging This study examined the relationship between different physical activity patterns and the risk of developing various brain disorders, including dementia, stroke, Parkinson's disease, depressive disorders, anxiety disorders, and bipolar disorders. The study found that the weekend
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@BensenHsu
BensenHsu
17 days
@NikoMcCarty The researchers wanted to create a system that can solve multiple computational problems using engineered bacterial cells. They took inspiration from artificial neural networks (ANNs) and designed a modular multicellular system that can perform various computations. The
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@BensenHsu
BensenHsu
1 month
@slavovLab The researchers in this study wanted to understand how proteins can have different amino acids than expected based on the genetic code. This can happen when the messenger RNA (mRNA) is translated into proteins in a way that deviates from the normal rules. The researchers
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@BensenHsu
BensenHsu
4 months
Be careful! AI can read minds @Nature research: AI networks reveal how flies find a mate Read the full paper here: #ai #researchpaper #mind #human #brain #neural Here are the key takeaways from the paper: 👇
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@BensenHsu
BensenHsu
7 days
@EricTopol @CellCellPress @Nature The study aimed to evaluate the safety, tolerability, and efficacy of autologous chemically induced pluripotent stem-cell-derived islets (CiPSC-islets) as a treatment for type 1 diabetes. The patient in this study had a long history of hard-to-control diabetes and previous
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@BensenHsu
BensenHsu
15 days
@karlerikmohlin @EvaRanehill @annahsandberg This study investigates the impact of PhD studies on the mental health of PhD students. Previous survey-based evidence has suggested that PhD students experience high levels of mental health problems, raising concerns about the well-being of early-career researchers and the
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@BensenHsu
BensenHsu
1 month
@quay_dr The researchers wanted to understand how modified ribonucleotides, commonly used in therapeutic mRNA, affect the accuracy of mRNA translation. They were particularly interested in whether these modifications could cause mistakes during protein synthesis. The researchers found
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@BensenHsu
BensenHsu
1 month
@maxewilkinson The study investigates a defense system called DRT2 that helps bacteria fight against viruses called phages. The DRT2 system has a special protein called a reverse transcriptase that can make DNA from RNA. The researchers found that when the bacteria were infected with phages,
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@BensenHsu
BensenHsu
24 days
@AlpacaAurelius The study investigates the use of magnesium to treat major depression and related mental health issues. Major depression is a serious mood disorder that can severely disrupt a person's life and lead to suicidal thoughts. Conventional antidepressant drugs are not always effective
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@BensenHsu
BensenHsu
1 month
@quay_dr The study aimed to explore the epidemiological and clinical characteristics of the 2019 novel coronavirus (2019-nCoV) pneumonia in Wuhan, China. The 2019-nCoV infection appeared to be more likely to affect older men with underlying medical conditions, and it could result in
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@BensenHsu
BensenHsu
3 months
@EricTopol @JAMAOphth The researchers found that patients with type 2 diabetes who were prescribed semaglutide had a higher risk of developing NAION (nonarteritic anterior ischemic optic neuropathy. NAION is a type of eye condition that can cause vision loss.) compared to those who were prescribed
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@BensenHsu
BensenHsu
1 month
@emollick The study examines the impact of high temperatures on the performance of students taking high-stakes exams, such as standardized tests that determine graduation and college admissions. The researchers use data from the New York City public school system to study this
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@BensenHsu
BensenHsu
28 days
@NikoMcCarty The researchers wanted to use the electrical signals from fungal mycelia to control robots. Fungi can produce electrical signals that are similar to the action potentials in animal neurons. The researchers thought they could use these fungal signals to make robots move. The
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@BensenHsu
BensenHsu
2 months
@EricTopol @JAMA_current The study found that heart disease and cancer remained the top two leading causes of death in the US throughout the 2019-2023 period. However, the rankings of other leading causes changed significantly during this time. COVID-19 emerged as the third leading cause of death in 2020
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@BensenHsu
BensenHsu
2 months
@EricTopol @cellhostmicrobe The study finds that alterations in gut microbiota composition and function can influence cognitive processes like memory, learning, and executive function. Specific bacterial taxa, microbial metabolic pathways, and gut viruses have been linked to cognitive performance. full
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@BensenHsu
BensenHsu
4 months
@peterjansen_ai @allen_ai @MSFTResearch @aclmeeting The findings suggest that while LLMs show promise, they are still unreliable as direct text-based world simulators, especially when it comes to capturing environment-driven transitions and transitions that require complex reasoning. The authors highlight the need for further
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@BensenHsu
BensenHsu
28 days
@ScienceMagazine The researchers wanted to study the ancient population size history of humans. Previous studies could only look at the recent population history, but the ancient history during the Pleistocene era was still unclear. The analysis revealed that human ancestors went through a
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@BensenHsu
BensenHsu
4 months
@ShegWoan26034 女 also means ‘woman’ in Chinese, but the second one is a bad word
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@BensenHsu
BensenHsu
1 month
@_akhaliq The paper presents Sapiens, a family of vision transformer models trained on a large dataset of human images. The goal is to develop models that can generalize well, be applicable to a wide range of tasks, and produce high-quality outputs. The results demonstrate the benefit of
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@BensenHsu
BensenHsu
2 months
@NikoMcCarty The CRISPRkit provides a cost-effective and accessible way for high school students to learn about gene editing. By using a cell-free system and smartphone-based measurement, the kit eliminates the need for expensive lab equipment. full paper:
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@BensenHsu
BensenHsu
2 months
@EricTopol @NatureAging The findings suggest that the aging process is not a simple, straightforward change but rather a complex series of changes in various biological molecules. The researchers identified two specific time periods, around ages 44 and 60, where major changes occurred in many molecules.
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@BensenHsu
BensenHsu
2 months
@AIatMeta @NVIDIAAI @huggingface The main objective is to investigate if pruning an existing LLM and then retraining it with a small fraction of the original training data can be an effective way to obtain smaller models, rather than training each model from scratch. The hypothesis is that this approach can
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@BensenHsu
BensenHsu
2 months
@EricTopol @NatImmunol @julienCMarie1 The study demonstrates that a specific immune cell population, when not properly controlled, can directly trigger the initiation of cancer. This expands our understanding of the complex relationship between the immune system and cancer development. full paper:
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@BensenHsu
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2 months
@EricTopol @Nature The study found that affected dairy cows displayed clinical signs such as decreased feed intake, respiratory distress, and a sudden drop in milk production. Viral RNA and infectious virus were consistently detected in milk samples, and the mammary gland was identified as the
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@BensenHsu
BensenHsu
2 months
@EricTopol @NatureGenet The findings suggest that the genetic architectures of COVID-19 and influenza are largely distinct, with few shared genetic risk factors. The identified influenza-associated variants likely influence the expression of genes involved in sialic acid metabolism, which is important
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@BensenHsu
BensenHsu
1 month
@AdamMGrant The study aimed to measure and understand how people differ in aspects of communication during social interaction. It examined facial behavior, which is an important part of how people communicate with each other. The studies found that facial expressivity is a stable individual
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@BensenHsu
BensenHsu
27 days
@KathaSchmack The study aims to understand the role of alternate RNA decoding in producing stable and abundant proteins in mammals. Alternate translation occurs when the genetic code is not followed exactly, leading to amino acid substitutions in the resulting proteins. The findings suggest
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@BensenHsu
BensenHsu
13 days
@emollick The study explores the persuasive capabilities of large language models (LLMs) like GPT-4, especially when they have access to personal information about the people they are debating with. The researchers are concerned that LLMs could be used to create convincing arguments and
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@BensenHsu
BensenHsu
1 month
@EricTopol The study investigates the relationship between diabetes, prediabetes, and brain aging. It explores whether a healthy lifestyle can counteract the negative impact of diabetes and prediabetes on brain health. Diabetes and even prediabetes appear to accelerate brain aging,
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@BensenHsu
BensenHsu
3 months
@EricTopol Compared to insulin, GLP-1RAs (glucagon-like peptide 1 receptor agonists) were associated with a significantly lower risk of 10 out of the 13 obesity-associated cancers, including gallbladder cancer, meningioma, pancreatic cancer, liver cancer, ovarian cancer, colorectal cancer,
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@BensenHsu
BensenHsu
1 month
@EricTopol @NatureMicrobiol The study investigates how SARS-CoV-2 evolves and adapts in different parts of the body, particularly in the lungs and the brain. The researchers were interested in understanding how the virus changes when it infects these different organs. The researchers found that the virus
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@BensenHsu
BensenHsu
1 month
@ElliotHershberg 1st paper: This study reveals a new way that bacteria can defend themselves against phage infections, by using a reverse transcriptase to create a special kind of DNA that can express a toxic protein. This adds to our understanding of the diverse ways that bacteria have evolved
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@BensenHsu
BensenHsu
4 months
🔥Trending on OpenRead🔥 "Pass the butter": A study on desktop-classic multitasking robotic arm based on advanced YOLOv7 and BERT Read the full paper here: Here are the key takeaways from the paper: 👇
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@BensenHsu
BensenHsu
1 month
@svpino The paper describes a new system for building task-oriented dialogue systems that combines the language understanding capabilities of large language models (LLMs) with the deterministic execution of business logic. The key advantages of the proposed system over the intent-based
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@BensenHsu
BensenHsu
3 months
@EricTopol @Nature @justsaysinmice @stuartacook1 @dukenus The study shows that genetic deletion or pharmacological inhibition of IL-11 extends lifespan in both male and female mice, with a median lifespan extension of over 20% in late-life treatment. This is a significant finding with potential translational implications for human
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@BensenHsu
BensenHsu
16 days
@GoogleAI The researchers studied a novel call discovered in acoustic recordings from the Mariana Archipelago, called "Biotwang". They wanted to determine which whale species is responsible for producing this call. The researchers confirmed that Biotwangs are produced by Bryde's whales
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@BensenHsu
BensenHsu
2 months
@EricTopol @Nature @UCSFMedicine The findings suggest that in some children, the immune response to the COVID-19 virus can trigger an autoimmune reaction where the body starts attacking its own SNX8 protein. This cross-reactivity between the virus and the human protein may be what causes the severe inflammation
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@BensenHsu
BensenHsu
3 months
@EricTopol The researchers found that different organs can age at different rates within the same person. About 20% of the people studied had one organ that was aging much faster than the other organs. They also found that faster aging of certain organs, like the heart and brain, was linked
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@BensenHsu
BensenHsu
1 month
@bindureddy The paper explores a simple yet effective prompting method called Re-Reading to enhance the reasoning capabilities of large language models (LLMs). The study is motivated by the observation that humans often re-read questions during problem-solving to improve their understanding.
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@BensenHsu
BensenHsu
2 months
@EricTopol This study advances our understanding of the mechanisms by which the brain can communicate with and influence the gut microbiome, a rapidly growing area of research. It highlights the importance of the glands of Brunner as a key interface between the nervous system and the gut
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@BensenHsu
BensenHsu
2 months
@EricTopol @NatImmunol The researchers were able to identify two new types of thymus cells that emerge with age and show how these cells can disrupt the normal function of the thymus. This is an important step towards understanding the aging process of the thymus and finding ways to maintain its
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@BensenHsu
BensenHsu
4 months
@ylecun @headinthebox Come on! @ylecun is pointing PhD students to the right direction, since LLMs are ruining PhDs in AI, CS, CE, etc.
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@BensenHsu
BensenHsu
4 months
How to build a time machine? Quantum time travel: The experiment to 'send a particle into the past' Read the full paper here: #timemachine #physics #experiment #research Here are the key takeaways from the paper: 👇
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@BensenHsu
BensenHsu
4 months
@EricTopol @NatureWaterJnl The study advances the understanding of the role of microplastics in shaping viral diversity, resistance gene dynamics, and virus-host relationships in the environment. It highlights the potential environmental and public health risks associated with microplastic-borne viral
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@BensenHsu
BensenHsu
1 month
@dribbble looks like knockoff 😅
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@BensenHsu
BensenHsu
2 months
@emollick The paper argues that machine psychology can provide valuable insights into the inner workings and emergent capabilities of LLMs, which may not be easily explained by simply inspecting the models' architectures or training data. It also cautions against the tendency to
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@BensenHsu
BensenHsu
2 months
@svpino The researchers argue that the perceived emergence of abilities in LLMs is primarily a result of their capacity for in-context learning, which allows them to perform well on tasks by learning from a few examples. They propose that instruction-tuning enables models to map
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@BensenHsu
BensenHsu
4 months
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@BensenHsu
BensenHsu
4 months
Why some people are easy to get sick? @CellCellPress research: FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice Read the full paper here: #health #immune #human #body Here are the key takeaways from the
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@BensenHsu
BensenHsu
3 months
@EricTopol @justsaysinmice @ScienceTM The findings suggest that targeting intracellular, synaptic, and seed-competent tau aggregates is crucial for effective tau immunotherapy, as these forms of tau are more closely linked to disease progression and cognitive decline. The intranasal delivery of TTCM2-ms (toxic tau
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@BensenHsu
BensenHsu
18 days
@EricTopol @uk_biobank @NatureHumBehav This study investigated the associations between loneliness and a wide range of diseases. It aimed to find out whether the links between loneliness and different health problems are actually caused by loneliness or if there are other factors involved. The study found that
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@BensenHsu
BensenHsu
4 months
@EricTopol @JCO_ASCO @ASCO @bensolomon1 @EricTopol This study provides important long-term data on the efficacy and safety of lorlatinib, a third-generation ALK inhibitor, in the first-line treatment of advanced ALK-positive NSCLC. The results set a new benchmark for targeted therapies in this disease and other solid
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@BensenHsu
BensenHsu
2 months
@mrsiipa The derived rules are crucial for understanding the mathematics behind the optimization and backpropagation used in training deep neural networks. The paper demonstrates how these matrix calculus concepts can be applied to compute the gradients of neuron activation and the neural
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@BensenHsu
BensenHsu
2 months
@EricTopol @ScienceMagazine @jonykipnis The study found that the way protocadherin genes are organized and regulated in the genome allows some neurons to express these proteins in a random way, while others have a more biased pattern of expression. This diversity in protocadherin barcodes helps neurons identify
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@BensenHsu
BensenHsu
1 month
@slavov_n The researchers in this study wanted to understand how proteins can have different amino acids than expected based on the genetic code. This can happen when the messenger RNA (mRNA) is translated into proteins in a way that deviates from the normal rules. The researchers
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@BensenHsu
BensenHsu
4 months
@EricTopol @NatureMedicine The study reveals divergent gut microbial signatures associated with age and metabolism, and demonstrates the utility of MA as an independent risk factor that modulates CVD risk in older adults with metabolic disturbances. Full paper:
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@BensenHsu
BensenHsu
4 months
@EricTopol @NatureComms The researchers identified a panel of 8 proteins (Granulin precursor, Mannan-binding-lectin-serine-peptidase-2, Endoplasmatic-reticulum-chaperone-BiP, Prostaglaindin-H2-D-isomaerase, Interceullular-adhesion-molecule-1, Complement C3, Dickkopf-WNT-signalling pathway-inhibitor-3,
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@BensenHsu
BensenHsu
13 days
@EricTopol @TheLancet @UKAMREnvoy @mtosterholm @RickABright The study discusses the problems with the current standard for diagnosing bloodstream infections, which is blood culture, and the need to adopt more modern, efficient, and resilient diagnostic methods. The study identifies the problems with blood culture, such as poor
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@BensenHsu
BensenHsu
3 months
@EricTopol @JExpMed @EllenFoxman @TimothyAWatkins @YalePediatrics @YaleMed The results suggest that the frequent infections with respiratory viruses and bacterial pathogens that children experience drive the heightened immune responses seen in their noses and throats. The immune system appears to be constantly activated, ready to fight off these
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@BensenHsu
BensenHsu
27 days
@NikoMcCarty The study investigates whether cyanobacteria, which are simple, single-celled organisms, can measure changes in day length (photoperiod) and use that information to prepare for seasonal changes, such as cold temperatures. This ability, called "photoperiodic timekeeping," was
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@BensenHsu
BensenHsu
2 months
@EricTopol @TheLancet @trishgreenhalgh @sivanmanoj @DrAPerlowski The paper covers the following key points: • Epidemiology: Long COVID can affect up to 50-85% of hospitalized patients and 10-35% of non-hospitalized patients, with vaccination reducing the risk. • Pathophysiology: Multiple mechanisms are proposed, including persistent virus or
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@BensenHsu
BensenHsu
3 months
@EricTopol @ScienceTM @Chaofan_Immune @Jie_Immunology @UVA This study provides important insights into the immune mechanisms behind the development of long COVID, which has been a major public health challenge. The findings suggest that targeting the IFN-γ signaling pathway may be a potential therapeutic approach for treating long COVID.
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@BensenHsu
BensenHsu
30 days
@EricTopol @Nature The study explores a newly developed "brain clock" that can determine whether a person's brain is aging faster than their chronological age suggests. The researchers investigated factors that may contribute to accelerated brain aging. The study found that people with Alzheimer's
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@BensenHsu
BensenHsu
3 months
@FrnkNlsn The paper covers several important results in information geometry: 1. The Fisher-Rao manifold and the Fisher-Rao distance, which provide a way to measure the dissimilarity between probability distributions. 2. Amari's dual α-geometry, which reveals the dualistic structure of
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@BensenHsu
BensenHsu
1 month
@EricTopol @TheEconomist The study compares life expectancy levels and within-country geographic variation in life expectancy across six high-income Anglophone countries (the USA, UK, Canada, Australia, Ireland, and New Zealand) between 1990 and 2018. Among the six countries, Australia has the highest
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@BensenHsu
BensenHsu
1 month
@emollick The paper explores the relationship between performance and ability. It investigates whether the most successful individuals are necessarily the most skilled, and whether failures always indicate lack of skill. The models show that when noise and rich-get-richer dynamics
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@BensenHsu
BensenHsu
1 month
@EricTopol @NEJM The study looked at the relationship between three blood biomarkers - high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) - and the risk of cardiovascular events in a group of healthy women over a 30-year period. The
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@BensenHsu
BensenHsu
4 months
@AlexGDimakis The authors connect the concept of transcendence to the rich literature on model ensembling and the "wisdom of the crowd" phenomenon. They also find that dataset diversity is a key requirement for enabling transcendence, as models trained on less diverse datasets fail to
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@BensenHsu
BensenHsu
2 months
@arankomatsuzaki The results suggest that utilizing test-time computation can be more effective than simply scaling up the model size, especially on easier and intermediate problems. This is because test-time computation enables the model to adaptively refine its outputs or search for better
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@BensenHsu
BensenHsu
4 months
@EricTopol @MedCellPress The CD19 CAR-T cell therapy resulted in an acceptable safety profile for both patients, with no occurrence of immune effector cell-associated neurotoxicity syndrome despite the detection of CAR-T cells in the cerebrospinal fluid. In one patient, there was a notable decrease in
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@BensenHsu
BensenHsu
1 month
@omarsar0 The paper presents a comprehensive report on compressing two large language models - Llama 3.1 8B and Mistral NeMo 12B - using pruning and distillation techniques. The goal is to create smaller models with comparable performance while reducing the cost of training. 1. The
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@BensenHsu
BensenHsu
4 months
@delia_cai Because he has blue eyes
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@BensenHsu
BensenHsu
2 months
@EricTopol @NatureGenet @decodegenetics @nanopore The results suggest that genetic variants, rather than DNA methylation itself, are the primary drivers of the relationship between DNA methylation and gene expression. The researchers propose two possible models to explain this: 1) the genetic variants affect transcription factor
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@BensenHsu
BensenHsu
4 months
@EricTopol @ImmunityCP @blish_lab The paper discusses several key challenges in LC research, including defining LC, deciphering the effects of vaccination, acute COVID-19 treatments, reinfection, and evolving SARS-CoV-2 variants, as well as discovering reproducible and generalizable mechanisms driving LC in
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@BensenHsu
BensenHsu
1 month
@EricTopol @JAMACardio The study aimed to investigate the effects of lipid-lowering therapy on coronary lesions with advanced atherosclerotic plaque features and higher risk for future events. Previous studies have looked at atherosclerotic changes in entire coronary segments, regardless of the
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@BensenHsu
BensenHsu
4 months
@Nature This study provides mechanistic insights into how paternal environmental exposures, through sperm-borne sncRNAs, can influence offspring metabolism. It identifies mt-tRNAs and their fragments as dynamic and diet-sensitive signals that are transferred from sperm to the oocyte at
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@BensenHsu
BensenHsu
2 months
@EricTopol @TheLancet @IldikoLingvay @psumithran1 The paper presents the following key findings: 1. Obesity is a complex, chronic, and progressive disease that substantially affects health, quality of life, and mortality. 2. Lifestyle interventions, including improvements in eating patterns, physical activity, stress management,
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@BensenHsu
BensenHsu
2 months
@0xluffyb The paper discusses two fundamental approaches to garbage collection - tracing and reference counting. Garbage collection is an important process in computer programming that automatically reclaims memory occupied by objects that are no longer in use. The paper argues that the
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