Prepare to be sick to death of me using this in every reply.
"This plan may sound appealing to people who know a little about the immune system, but the drawbacks are clear to people who know a lot about the immune system and also to people who don't know anything about it."
@Peston
For those saying we don't isolate for other diseases, here is a list of diseases we exclude children from school with, most of which are less serious than covid.
Chickenpox, D&V, Giardia, Typhoid and Paratyphoid fever, E coli, Bacillary Dysentery (Shigella), Campylobacter,
My husband got a "we're worried about you because you won't let us infect you with COVID" letter from his father. Apparently he didn't feel very welcome back in March when they visited because we made them sit outside. We've never let them inside due to COVID so I don't know why
@flyingspghetti
You guys pay more with insurance than we would pay for private healthcare without insurance in the UK. I don't know why you all aren't rioting.
The bad news is coming thick and fast I'm afraid. The VA has published another large study, this time looking at outcomes of SARS2 reinfections.
TL;DR each infection is on average worse than the last in terms of mortality, hospitalisation and long covid.
@xcevutx
@hjelle_brian
Covid cases in Japan plummeted because they switched to an extreme focus on respiratory hygiene. Everyone wears N95s even on the street, businesses have CO2 monitors with values clearly displayed on site and in an app in some cases, you can eat in a restaurant but you aren't
Hospitalisation
A person with one infection is 1.3x more likely to be hospitalized in the 6 months following infection than non-infected controls.
A person with two infections is 5.6x more likely to be hospitalized in the 6 months following infection than non-infected controls.
2.4% of reinfected people were dead at 6 months who would likely have lived if not reinfected.
Reinfections are worse on average and it's likely that if you keep getting reinfected SARS2 will eventually kill you. Do everything you can to avoid infection.
them when they'd finished eating. He's been stewing about this for 8 months. Husband hasn't let me read the letter yet, apparently it says some horrible things about me though.
they expected anything different. He's also in a huff because they agreed that nibbles would be fine then rang us up the night before saying they wanted a hot meal and we weren't able to accommodate that due to short notice so they had to pick up ready meals on the way.
@emilydohrk
@gramnegativity
@soFISHtication
As a trained virologist with coeliac disease that leaves me bedbound for weeks/months with even the slightest cross contamination - I'll still have the cookie dough.
His major problem with this is that we told them we weren't going to heat up anything with gluten in it because even a tiny bit of cross contamination makes me even sicker for months. He'd also had a toddler tantrum on the day because they were going for a walk with my husband
@1goodtern
Reminds of my friend who thought she couldn't get pregnant because she had lots of unprotected sex and hadn't gotten pregnant. She had a baby at 17.
and we wanted them to wear a mask because they weren't being careful about COVID and the newer variants are more transmissible. He went off to sit in the car instead of the walk and never even bothered to say as much as hello to me because I was resting and was coming out to see
In summary, you are more than 5x more likely to be hospitalised on your second infection and 2x as likely as that on your third.
You are 2x more likely to develop long covid on your second infection and 1.5x more likely than that on your third.
Just the head of communications for
@WHO
punching down on someone who actually works to improve health. Is anyone in a leadership role there actually good at their job?
@i_petersen
I suggest you spend less time talking to eugenicists like Francois Balloux and more time speaking to people who understand immunology and virology or who have just been paying attention for the last two years.
Mortality
A person with reinfectionis 2.1x more likely to die in the next 6 months compared with people with one infection. Out of every 1,000 people with reinfection, 24 more people died than in the once infected group.
Vaccination status made negligible difference.
@lolhiphop
People really need to work through their pandemic grief rather than getting constantly triggered by anything that reminds them we're still in a pandemic.
@DugSnupe
@baekdal
Even better, you can have any number of problems on admission such as stroke, heart attack, pulmonary embolism that were directly caused by covid and even if you're still testing positive you'll probably go down as incidental covid.
@BiologyAwesome
I think that a lot of older people have decided they'd rather have the holidays and meals out and if they die early they're only missing out on a few years. They're angry that we won't go along with it even though we're looking at decades of life lost/(further) disability.
@mildanalyst
And probably bus seats, hand rails, groceries, mail... Plus it can be stable for months on surfaces so you can't just quarantine stuff for a few days and you literally catch it through your skin so hand washing might not save you. Our monkeypox protocol is much harder than SARS'.
@FinchTH
So SARS2 downregulates MHC1 meaning that T cells don't recognise and kill infected cells and now we find out that the cells which recognise and kill cells without enough MHC1 are also evaded. Tell me again how SARS2 isn't chronic.
Sequelae
A person with one infection is 1.35x more likely to experience at least one new symptom in the 6 months following infection than non-infected controls.
A person with 2 infections is 2.1x more likely to experience at least one new symptom in the 6 months following infection than non-infected.
A person with 3 infections is 3x more likely to experience at least one new symptom in the 6 months following infection than non-infected.
@chrischirp
Life hasn't felt so surreal since February 2020 when I could see the deadly pandemic about to hit the UK and everyone else was apparently skiing right next to the European epicenter.
@MeetJess
Ooh. This metric might be as accurate as the ONS for signalling the start of a new wave without the lag. Flight attendants are very high contact so are going to start catching it in high numbers as soon as they wane or a new immune evading variant turns up.
@nadhimzahawi
Translation: Thanks to teachers risking their lives and working themselves to the point of burnout we can pretend that kids are actually getting an education rather than watching Finding Nemo with three other classes in the hall. Without this we'd have to do something about the
@StephTaitWrites
This week has been really rough on a lot of us. The gaslighting from people we thought were in our camp has been unreal. With the last mAbs about to fail and the shine wearing off Paxlovid, I think we're going to see a change of message from the elites soon.
@FascistCentre
This is why China cracked down on it - they reacted as if the worst case scenario was actually possible. I don't know if western government science advisors didn't have the imagination to see that this could be an extinction level event or if they dismissed it as unlikely.
@doctuhjay
I've been saying this for a while now - once everyone's had it a few times everyone's going to get fed up with being properly sick multiple times a year and modify their behaviour/demand government action. Spreading your germs will become completely socially unacceptable.
@NeleHelena
Yeah, "good news - you don't have X" actually means "good news - you're going to have to live with your intolerable symptoms indefinitely".
@ITV
@Suej1959
Like others have said, you could easily get a three part series about MECFS - particularly the PACE trial, psychologizing of the disease to save the DWP money, the rewarding of psychologists who've ruined lives, the lack of funding and the criminal waste of grant money on GET/CBT
@qewperp
@KatePri14608408
2m isn't magic either - you can get unlucky with wind direction. I've certainly had a lungful of someone's cigarette from 10-15 meters away.
@TRyanGregory
"I don't like these gloomy papers so I'm going to cherry pick the one with the lowest number and pretend that the estimate they give isn't still catastrophic."
@JHowardBrainMD
@adamcifu
Even if SARS2 disappeared tomorrow there are other airborne diseases. Really it was madness that we didn't always wear masks in medical settings.
@YouAreLobbyLud
A PAPR is much cheaper than being (further) disabled. They're also cheaper than missing a couple of weeks of work if you have no sick pay.
@M8Void
Had a conversation with the in laws last year where they told me the local hospital had 12 hour ambulance queues outside and then proceeded to list all the parties they'd been to and talked about my father in law going up ladders to fix the roof.
@Logical1966
@andymoz78
This is appalling and exactly why vulnerable people are avoiding the hospital. Is there any way to continue your treatment at home. Could they provide portable oxygen/nebulizer, switch IV antibiotics for tablets etc?
@Oldboatie
I always knew that the wearing masks to protect others messaging was a bad idea. People are just too selfish for that to work for long and it doesn't take many people not doing it before people start wondering why they're bothering.
@CDotTweets
@arocxo
There are some pretty nasty coronaviruses that infect animals so when vets hear coronavirus they think of those rather than the common cold.
@JohnWest_JAWS
I hope that's wrong. I desperately want the Tories out but I don't think Labour having that much of a majority would be a good thing either. I think a Labour/Lib Dem coalition with the Lib Dems not bottling it this time would be the best outcome.
@jbloom_lab
The "definitely not a lab leak" crowd are odd. A new coronavirus just happening to emerge in the same city as a virology lab that we know was collecting exotic coronaviruses would be a massive coincidence. Not saying it definitely wasn't the wet market but WIV seems more likely.
@FinchTH
He's been quietly turning minimiser for a while now. Once they start posting selfies of themselves right next to other people indoors with no masks then you've got ~6 months max until they start gaslighting covid-cautious people.
@Simon10tbk
@xrayleak
@fitterhappierAJ
reducing transcription of MHC1 (by suppressing proteins that are necessary for transcription of MHC1). Less MHC1 on the cells mean there's less chance of viral proteins being presented to T cells and the immune system being alerted to infection.
@YouAreLobbyLud
@NjbBari3
@fitterhappierAJ
This is monumentally bad and what I've been worried about since the beginning of the pandemic. With enough reinfections SARS2's mortality rate will likely be 100%. We're in the middle of an extinction level event and people are more upset about airport queues.
@CovidSolidarit1
There's been a definite pattern of leaders being exposed or catching covid and then dramatically loosening restrictions. It could be either a toxoplasmosis type behavioural change or a psychological effect similar to how addicts often try to get people to join them.
@quackduck314
I'd love to see some sequencing on that. If someone can still produce infectious virus after three years then we need to get this documented.
@alexmeshkin
- could you help?
@YouAreLobbyLud
@micah_arsham
@greg_travis
We've put people in space, have figured out how save people's lives using spare parts from dead people and carry the entire sum of human knowledge in our pockets but my god we're stupid.
@seahorse4000
I'm so sorry. I've been shouting about how we need to do something from my little corner of Twitter. I doubt it's making a lot of difference but I'm going to keep b don't it because it's all I can do.
@NjbBari3
My mother in law looks a lot older than she did last year. The in laws don't take covid very seriously anymore so I assume they've had an infection or two that they haven't told us about.
@wrestle38509187
@ravgup33_ravi
If we end up with something as transmissible and deadly as delta with a high degree of immune escape then we'll be back to square -2. If original antigenic sin applies then we're staying there.
@Simon10tbk
@xrayleak
@fitterhappierAJ
Cells have a protein called MHC1 on their surface. Your cells are making various proteins all the time - this is done by transcribing the relevant gene into mRNA which then gets translated into the protein. A portion of these proteins get chopped up and the bits are mounted on
@1goodtern
WHO talking about long covid, WH talking about ventilation. Do you think the elites are getting twitchy about the new immune evasive variants?
@tigresseleanor
I think we're now doing less than we normally do about flu. Every hospital patient with suspicion of flu is tested during flu season but doctors are being pressured to only test patients with fever who need oxygen for SARS2.
@bookwych
To paraphrase Groucho Marx - I wouldn't want anyone in my house who wanted to be in my house. Stand firm - they've probably done ten other risky things on the way to see you.