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Alison Nolan

@AlisonNolan9

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Has a few biology degrees, did a virology PhD. Zero covid zealot™ Hard-line scientist© Covid avoider. #MECFS

Sussex
Joined December 2012
Don't wanna be here? Send us removal request.
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@AlisonNolan9
Alison Nolan
3 years
Prepare to be sick to death of me using this in every reply. "This plan may sound appealing to people who know a little about the immune system, but the drawbacks are clear to people who know a lot about the immune system and also to people who don't know anything about it."
@xkcd
Randall Munroe
3 years
Immunity
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@AlisonNolan9
Alison Nolan
3 years
@Peston For those saying we don't isolate for other diseases, here is a list of diseases we exclude children from school with, most of which are less serious than covid. Chickenpox, D&V, Giardia, Typhoid and Paratyphoid fever, E coli, Bacillary Dysentery (Shigella), Campylobacter,
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@AlisonNolan9
Alison Nolan
1 year
My husband got a "we're worried about you because you won't let us infect you with COVID" letter from his father. Apparently he didn't feel very welcome back in March when they visited because we made them sit outside. We've never let them inside due to COVID so I don't know why
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@AlisonNolan9
Alison Nolan
2 years
@flyingspghetti You guys pay more with insurance than we would pay for private healthcare without insurance in the UK. I don't know why you all aren't rioting.
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@AlisonNolan9
Alison Nolan
2 years
The bad news is coming thick and fast I'm afraid. The VA has published another large study, this time looking at outcomes of SARS2 reinfections. TL;DR each infection is on average worse than the last in terms of mortality, hospitalisation and long covid.
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@AlisonNolan9
Alison Nolan
3 years
@Peston Cryptosporidiosis, Hepatitis A, Impetigo, Influenza (advisory), Measels, Mumps, Rotavirus, Rubella, Scabies, Scarlet Fever, TB, Whooping cough.
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@AlisonNolan9
Alison Nolan
2 years
@RachaelBott1 @AltenbergLee @ToshiAkima Covid proteins can form clumps in your brain that are toxic to brain cells - resembles what is seen in Alzheimer's.
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@AlisonNolan9
Alison Nolan
2 years
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@AlisonNolan9
Alison Nolan
3 years
@xcevutx @hjelle_brian Covid cases in Japan plummeted because they switched to an extreme focus on respiratory hygiene. Everyone wears N95s even on the street, businesses have CO2 monitors with values clearly displayed on site and in an app in some cases, you can eat in a restaurant but you aren't
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@AlisonNolan9
Alison Nolan
2 years
Hospitalisation A person with one infection is 1.3x more likely to be hospitalized in the 6 months following infection than non-infected controls. A person with two infections is 5.6x more likely to be hospitalized in the 6 months following infection than non-infected controls.
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@AlisonNolan9
Alison Nolan
2 years
2.4% of reinfected people were dead at 6 months who would likely have lived if not reinfected. Reinfections are worse on average and it's likely that if you keep getting reinfected SARS2 will eventually kill you. Do everything you can to avoid infection.
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@AlisonNolan9
Alison Nolan
1 year
them when they'd finished eating. He's been stewing about this for 8 months. Husband hasn't let me read the letter yet, apparently it says some horrible things about me though.
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@AlisonNolan9
Alison Nolan
1 year
they expected anything different. He's also in a huff because they agreed that nibbles would be fine then rang us up the night before saying they wanted a hot meal and we weren't able to accommodate that due to short notice so they had to pick up ready meals on the way.
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@AlisonNolan9
Alison Nolan
3 years
@emilydohrk @gramnegativity @soFISHtication As a trained virologist with coeliac disease that leaves me bedbound for weeks/months with even the slightest cross contamination - I'll still have the cookie dough.
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@AlisonNolan9
Alison Nolan
1 year
@EmergMedDr Undiagnosed, pneumonia and China are not words I like to see in a sentence together.
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@AlisonNolan9
Alison Nolan
1 year
His major problem with this is that we told them we weren't going to heat up anything with gluten in it because even a tiny bit of cross contamination makes me even sicker for months. He'd also had a toddler tantrum on the day because they were going for a walk with my husband
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@AlisonNolan9
Alison Nolan
2 years
@1goodtern Reminds of my friend who thought she couldn't get pregnant because she had lots of unprotected sex and hadn't gotten pregnant. She had a baby at 17.
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@AlisonNolan9
Alison Nolan
1 year
and we wanted them to wear a mask because they weren't being careful about COVID and the newer variants are more transmissible. He went off to sit in the car instead of the walk and never even bothered to say as much as hello to me because I was resting and was coming out to see
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@AlisonNolan9
Alison Nolan
2 years
In summary, you are more than 5x more likely to be hospitalised on your second infection and 2x as likely as that on your third. You are 2x more likely to develop long covid on your second infection and 1.5x more likely than that on your third.
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@AlisonNolan9
Alison Nolan
2 years
A person with three infections is 11.3x more likely to be hospitalized in the 6 months following infection than non-infected controls.
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@AlisonNolan9
Alison Nolan
2 years
Just the head of communications for @WHO punching down on someone who actually works to improve health. Is anyone in a leadership role there actually good at their job?
@gabbystern
Gabby Stern
2 years
Another grotesque tweet. For shame, @annie_sparrow .
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@AlisonNolan9
Alison Nolan
3 years
@i_petersen I suggest you spend less time talking to eugenicists like Francois Balloux and more time speaking to people who understand immunology and virology or who have just been paying attention for the last two years.
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@AlisonNolan9
Alison Nolan
2 years
Mortality A person with reinfectionis 2.1x more likely to die in the next 6 months compared with people with one infection. Out of every 1,000 people with reinfection, 24 more people died than in the once infected group. Vaccination status made negligible difference.
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@AlisonNolan9
Alison Nolan
1 year
@lolhiphop People really need to work through their pandemic grief rather than getting constantly triggered by anything that reminds them we're still in a pandemic.
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@AlisonNolan9
Alison Nolan
3 years
@DugSnupe @baekdal Even better, you can have any number of problems on admission such as stroke, heart attack, pulmonary embolism that were directly caused by covid and even if you're still testing positive you'll probably go down as incidental covid.
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@AlisonNolan9
Alison Nolan
1 year
@BiologyAwesome I think that a lot of older people have decided they'd rather have the holidays and meals out and if they die early they're only missing out on a few years. They're angry that we won't go along with it even though we're looking at decades of life lost/(further) disability.
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@AlisonNolan9
Alison Nolan
2 years
@mildanalyst And probably bus seats, hand rails, groceries, mail... Plus it can be stable for months on surfaces so you can't just quarantine stuff for a few days and you literally catch it through your skin so hand washing might not save you. Our monkeypox protocol is much harder than SARS'.
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@AlisonNolan9
Alison Nolan
2 years
@FinchTH So SARS2 downregulates MHC1 meaning that T cells don't recognise and kill infected cells and now we find out that the cells which recognise and kill cells without enough MHC1 are also evaded. Tell me again how SARS2 isn't chronic.
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@AlisonNolan9
Alison Nolan
2 years
Sequelae A person with one infection is 1.35x more likely to experience at least one new symptom in the 6 months following infection than non-infected controls.
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@AlisonNolan9
Alison Nolan
3 years
@xcevutx @hjelle_brian allowed to talk while doing so. It's only a mystery if you don't understand how SARS2 spreads.
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@AlisonNolan9
Alison Nolan
2 years
@FinchTH Can we stop repeatedly infecting everyone now please?
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@AlisonNolan9
Alison Nolan
2 years
A person with 2 infections is 2.1x more likely to experience at least one new symptom in the 6 months following infection than non-infected. A person with 3 infections is 3x more likely to experience at least one new symptom in the 6 months following infection than non-infected.
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@AlisonNolan9
Alison Nolan
2 years
@FinchTH Sod restaurants, I just want to be able to access medical care without worrying about catching a disease that will likely further disable me.
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@AlisonNolan9
Alison Nolan
3 years
@chrischirp Life hasn't felt so surreal since February 2020 when I could see the deadly pandemic about to hit the UK and everyone else was apparently skiing right next to the European epicenter.
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@AlisonNolan9
Alison Nolan
2 years
@MeetJess Ooh. This metric might be as accurate as the ONS for signalling the start of a new wave without the lag. Flight attendants are very high contact so are going to start catching it in high numbers as soon as they wane or a new immune evading variant turns up.
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@AlisonNolan9
Alison Nolan
3 years
@nadhimzahawi Translation: Thanks to teachers risking their lives and working themselves to the point of burnout we can pretend that kids are actually getting an education rather than watching Finding Nemo with three other classes in the hall. Without this we'd have to do something about the
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@AlisonNolan9
Alison Nolan
2 years
@StephTaitWrites This week has been really rough on a lot of us. The gaslighting from people we thought were in our camp has been unreal. With the last mAbs about to fail and the shine wearing off Paxlovid, I think we're going to see a change of message from the elites soon.
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@AlisonNolan9
Alison Nolan
2 years
@ChristosArgyrop Nah. Get rabies to avoid getting all diseases.
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@AlisonNolan9
Alison Nolan
2 years
@FascistCentre This is why China cracked down on it - they reacted as if the worst case scenario was actually possible. I don't know if western government science advisors didn't have the imagination to see that this could be an extinction level event or if they dismissed it as unlikely.
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@AlisonNolan9
Alison Nolan
3 years
@doctuhjay I've been saying this for a while now - once everyone's had it a few times everyone's going to get fed up with being properly sick multiple times a year and modify their behaviour/demand government action. Spreading your germs will become completely socially unacceptable.
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@AlisonNolan9
Alison Nolan
2 years
@antartica81 @Philsbodydouble I feel like if we could make out the writing we'd see that her programme is upside down.
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@AlisonNolan9
Alison Nolan
2 years
@PCAdams1950 @cocosmompdx @makeupartist524 I really don't understand this mindset. The people who are the worst for it are often just a decade or two off 70 themselves.
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@AlisonNolan9
Alison Nolan
1 year
@NeleHelena Yeah, "good news - you don't have X" actually means "good news - you're going to have to live with your intolerable symptoms indefinitely".
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@AlisonNolan9
Alison Nolan
10 months
@ITV @Suej1959 Like others have said, you could easily get a three part series about MECFS - particularly the PACE trial, psychologizing of the disease to save the DWP money, the rewarding of psychologists who've ruined lives, the lack of funding and the criminal waste of grant money on GET/CBT
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@AlisonNolan9
Alison Nolan
3 years
@qewperp @KatePri14608408 2m isn't magic either - you can get unlucky with wind direction. I've certainly had a lungful of someone's cigarette from 10-15 meters away.
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@AlisonNolan9
Alison Nolan
2 years
@TRyanGregory "I don't like these gloomy papers so I'm going to cherry pick the one with the lowest number and pretend that the estimate they give isn't still catastrophic."
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@AlisonNolan9
Alison Nolan
2 years
@JHowardBrainMD @adamcifu Even if SARS2 disappeared tomorrow there are other airborne diseases. Really it was madness that we didn't always wear masks in medical settings.
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@AlisonNolan9
Alison Nolan
3 years
@nadhimzahawi pandemic which is still killing and disabling a horrific number of people.
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@AlisonNolan9
Alison Nolan
1 year
@brownecfm I don't like the words undiagnosed, pneumonia and China appearing in a sentence together.
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@AlisonNolan9
Alison Nolan
9 months
@YouAreLobbyLud A PAPR is much cheaper than being (further) disabled. They're also cheaper than missing a couple of weeks of work if you have no sick pay.
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@AlisonNolan9
Alison Nolan
3 years
@Debs_Kropotkin Yeah. Tried to return something last week and had a panic attack due to everyone acting like there was no pandemic.
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@AlisonNolan9
Alison Nolan
2 years
@Inadarkwood The gaslighting is extreme, it takes a very strong will and a community of people who can still see the truth to resist it.
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@AlisonNolan9
Alison Nolan
1 year
@M8Void Had a conversation with the in laws last year where they told me the local hospital had 12 hour ambulance queues outside and then proceeded to list all the parties they'd been to and talked about my father in law going up ladders to fix the roof.
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@AlisonNolan9
Alison Nolan
2 years
@Logical1966 @andymoz78 This is appalling and exactly why vulnerable people are avoiding the hospital. Is there any way to continue your treatment at home. Could they provide portable oxygen/nebulizer, switch IV antibiotics for tablets etc?
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@AlisonNolan9
Alison Nolan
2 years
@TRyanGregory @dgurdasani1 People like Deepti and I have to make difficult decisions about our healthcare because of people like him.
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@AlisonNolan9
Alison Nolan
3 years
@Kit_Yates_Maths False dichotomy - JCVI are an antivax group.
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@AlisonNolan9
Alison Nolan
3 years
@Sandyboots2020 That sounds like MIS-C - she really need to see a doctor.
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@AlisonNolan9
Alison Nolan
1 year
@jneill If you're on web switch to app or vice versa - you'll get a bit of extra use that way. Seems Twitter is DDOSing itself.
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@AlisonNolan9
Alison Nolan
2 years
@Oldboatie I always knew that the wearing masks to protect others messaging was a bad idea. People are just too selfish for that to work for long and it doesn't take many people not doing it before people start wondering why they're bothering.
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@AlisonNolan9
Alison Nolan
3 years
@GrahamPotts @Kit_Yates_Maths I'd really hoped the pandemic world have put an end to people spreading their germs about.
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@AlisonNolan9
Alison Nolan
3 years
@CDotTweets @arocxo There are some pretty nasty coronaviruses that infect animals so when vets hear coronavirus they think of those rather than the common cold.
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@AlisonNolan9
Alison Nolan
3 years
@JoeGrowling @AdamBienkov Is that his real smile or has it been photoshopped? It has a bit of a Black Hole Sun feeling to it.
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@AlisonNolan9
Alison Nolan
2 years
@BonnieLextra @Scampboi @metraux_julia Mindfulness is the worst for my pain as it makes me notice all the pain that I was successfully ignoring.
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@AlisonNolan9
Alison Nolan
3 years
@Kit_Yates_Maths Feeding your kid = just delaying their death, why bother?
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@AlisonNolan9
Alison Nolan
2 years
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@AlisonNolan9
Alison Nolan
3 years
@FaroukdEngineer @globalhlthtwit It's the mild memory loss.
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@AlisonNolan9
Alison Nolan
3 years
@lottieflying @Kit_Yates_Maths And this is why I'm never doing anything that isn't 100% necessary ever again.
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@AlisonNolan9
Alison Nolan
1 year
@JohnWest_JAWS I hope that's wrong. I desperately want the Tories out but I don't think Labour having that much of a majority would be a good thing either. I think a Labour/Lib Dem coalition with the Lib Dems not bottling it this time would be the best outcome.
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@AlisonNolan9
Alison Nolan
3 years
@jbloom_lab The "definitely not a lab leak" crowd are odd. A new coronavirus just happening to emerge in the same city as a virology lab that we know was collecting exotic coronaviruses would be a massive coincidence. Not saying it definitely wasn't the wet market but WIV seems more likely.
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@AlisonNolan9
Alison Nolan
1 year
@PianoTchrStaci Sounds like you dodged a bullet there!
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@AlisonNolan9
Alison Nolan
1 year
@1goodtern Matches my highly scientific how much coughing can I hear from people passing my house index.
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@AlisonNolan9
Alison Nolan
2 years
@FinchTH He's been quietly turning minimiser for a while now. Once they start posting selfies of themselves right next to other people indoors with no masks then you've got ~6 months max until they start gaslighting covid-cautious people.
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@AlisonNolan9
Alison Nolan
2 years
@CUH_NHS Can we get virtual MRIs and virtual blood tests?
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@AlisonNolan9
Alison Nolan
2 years
@1goodtern The worst covid enthusiasts aren't far off the age they deem disposable - I can't understand their mindset at all.
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@AlisonNolan9
Alison Nolan
2 years
@Simon10tbk @xrayleak @fitterhappierAJ reducing transcription of MHC1 (by suppressing proteins that are necessary for transcription of MHC1). Less MHC1 on the cells mean there's less chance of viral proteins being presented to T cells and the immune system being alerted to infection.
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@AlisonNolan9
Alison Nolan
2 years
@YouAreLobbyLud @NjbBari3 @fitterhappierAJ This is monumentally bad and what I've been worried about since the beginning of the pandemic. With enough reinfections SARS2's mortality rate will likely be 100%. We're in the middle of an extinction level event and people are more upset about airport queues.
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@AlisonNolan9
Alison Nolan
2 years
@YouAreLobbyLud Scrolled through the whole hashtag and found one guy in an aura and one with a baggy blue for an earring.
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@AlisonNolan9
Alison Nolan
3 years
@i_petersen @Dr2NisreenAlwan @chrischirp I don't want anything to do with a neurotropic virus that depletes naive T cells thank you very much.
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@AlisonNolan9
Alison Nolan
2 years
@Michael59503746 @chronicallybeee A massive chunk of the covid cautious community are autistic.
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@AlisonNolan9
Alison Nolan
3 years
@CovidSolidarit1 There's been a definite pattern of leaders being exposed or catching covid and then dramatically loosening restrictions. It could be either a toxoplasmosis type behavioural change or a psychological effect similar to how addicts often try to get people to join them.
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@AlisonNolan9
Alison Nolan
2 years
@oliver_phil @mildanalyst Even changing the years to days is pushing it slightly.
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@AlisonNolan9
Alison Nolan
2 years
@ask_aubry "women who fuck on the first date are worthless" - exact same guy, probably.
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@AlisonNolan9
Alison Nolan
2 years
@TheKrakenSays @fitterhappierAJ Why does she think the third infection has given her super-immunity when the first two didn't?
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@AlisonNolan9
Alison Nolan
2 years
@quackduck314 I'd love to see some sequencing on that. If someone can still produce infectious virus after three years then we need to get this documented. @alexmeshkin - could you help?
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@AlisonNolan9
Alison Nolan
3 years
@YouAreLobbyLud @micah_arsham @greg_travis We've put people in space, have figured out how save people's lives using spare parts from dead people and carry the entire sum of human knowledge in our pockets but my god we're stupid.
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@AlisonNolan9
Alison Nolan
3 years
@seahorse4000 I'm so sorry. I've been shouting about how we need to do something from my little corner of Twitter. I doubt it's making a lot of difference but I'm going to keep b don't it because it's all I can do.
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@AlisonNolan9
Alison Nolan
2 years
@NjbBari3 My mother in law looks a lot older than she did last year. The in laws don't take covid very seriously anymore so I assume they've had an infection or two that they haven't told us about.
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@AlisonNolan9
Alison Nolan
3 years
@wrestle38509187 @ravgup33_ravi If we end up with something as transmissible and deadly as delta with a high degree of immune escape then we'll be back to square -2. If original antigenic sin applies then we're staying there.
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@AlisonNolan9
Alison Nolan
2 years
@Simon10tbk @xrayleak @fitterhappierAJ Cells have a protein called MHC1 on their surface. Your cells are making various proteins all the time - this is done by transcribing the relevant gene into mRNA which then gets translated into the protein. A portion of these proteins get chopped up and the bits are mounted on
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@AlisonNolan9
Alison Nolan
1 year
@Pednpsy13 @ReesiePeacie Remember that feeling of hope for humanity in 2020 when the sky was clear of planes and everyone was in it together?
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@AlisonNolan9
Alison Nolan
2 years
@margal @ErinBromage Both pilots fell asleep on a flight recently. Luckily one woke up before anything bad happened.
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@AlisonNolan9
Alison Nolan
3 years
@ThemisJ3 @trishgreenhalgh That is absolutely terrifying!
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@AlisonNolan9
Alison Nolan
2 years
@silentanb COVID can cause coeliac disease.
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@AlisonNolan9
Alison Nolan
1 year
@KatePri14608408 Do they want their ~9,000 international students to hop on a plane?
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@AlisonNolan9
Alison Nolan
3 years
@ChristosArgyrop As an asthmatic, I can confirm that problems with your bronchioles make it really difficult to get oxygen to your alveoli.
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@AlisonNolan9
Alison Nolan
2 years
@1goodtern WHO talking about long covid, WH talking about ventilation. Do you think the elites are getting twitchy about the new immune evasive variants?
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@AlisonNolan9
Alison Nolan
2 years
@tigresseleanor I think we're now doing less than we normally do about flu. Every hospital patient with suspicion of flu is tested during flu season but doctors are being pressured to only test patients with fever who need oxygen for SARS2.
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@AlisonNolan9
Alison Nolan
2 years
@YouAreLobbyLud Were medical conferences this naff before SARS2 or is all the superspreadery singing and dancing new?
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@AlisonNolan9
Alison Nolan
1 year
@bookwych To paraphrase Groucho Marx - I wouldn't want anyone in my house who wanted to be in my house. Stand firm - they've probably done ten other risky things on the way to see you.
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