Interested in single-cell fate tracing in a variety of cancer and stem cell contexts? We have postdoc positions funded by Pew, CZI, and others. Reach out if interested!
Thrilled to be selected as a Pew-Stewart Scholar! Grateful for my past and current mentors for their support, and for my lab members to continuing to push the boundaries in cancer and more.
Excited to share updated FateMap paper in
@Nature
w
@arjunrajlab
. We show that diverse resistant fates can arise from homogenous cells upon drug exposure+ the fates over weeks/months in drug are decided even before drug addition
@pennbioeng
@NorthwesternU
.
@yogeshgoyal03
just accepted our offer and will be joining our Department early in 2022. Yogesh's lab will be developing quantitative experimental and theoretical frameworks to delineate cellular plasticity and fate choices in developing tissues and single cancer cells.
1/ Super excited to share our new work with
@arjunrajlab
on developing and implementing FateMap to reveal molecular and functional diversity in resistant fate clones emerging from homogenous cells after anti-cancer treatment
@pennbioeng
@NU_CDB
@NUSynBio
Thrilled to be selected as a Pew-Stewart Scholar! Grateful for my past and current mentors for their support, and for my lab members to continuing to push the boundaries in cancer and more.
NEW: We're excited to announce the 37 researchers joining our 2024 class of scholars and fellows! 👏
Through their research into brain cancer, respiratory infections, antibiotic resistance, and more, these scientists will help advance biomedical research.
Hey
@SlackHQ
, I accidentally paid corporate price for my research/educational lab at Northwestern University, and after realizing it 5 days later, I contacted you. Your staff tells me I will not be refunded for the extra 85% I paid. I would really like my $$ back.
Please help RT
Thrilled for my lab's first trainee
@JonasBraun97
(who literally opened the first of boxes
@NU_CDB
@NUSynBio
who has accepted an offer from
@Princeton
Quantitative and Computational Biology graduate program for his PhD. Excited for him to spend his time at my old stomping grounds
Excited to be a part of the new cohort of Young Investigator Awardees from the
@CancerRF
! We have postdoc positions in single cell cancer biology. Please DM me for questions.
We're proud to announce our 2023 Young Investigator Award recipients!
Read about their innovative work in the name of cancer research over on our blog:
#cancerresearch
Entering my (hacked) office space this am to be pleasantly surprised by this effort from my truly international and wonderful group!
@NU_CDB
@NUSynBio
@NUFeinbergMed
Very excited to be a part of the
@BWFUND
CASI awardees! Thank you
@arjunrajlab
@pennbioeng
+ the entire lab for their support. Also thanks to my other granting institutions
@SchmidtFellows
and JCC. Shout out to
@PepLarkin
for being generous and patient with my questions!
Excited to share updated FateMap paper in
@Nature
w
@arjunrajlab
. We show that diverse resistant fates can arise from homogenous cells upon drug exposure+ the fates over weeks/months in drug are decided even before drug addition
@pennbioeng
@NorthwesternU
Interested in reliably and robustly extracting ground-truth singlets in your scRNA-seq datasets? Excited to share a project from
@yogeshgoyallab
and Ziyang Zhang, using DNA barcodes to identify doublets in single-cell RNA sequencing data (1/
SciTwitter: I am preparing a 2hr class to my lab and lab friends on PCA and more broadly dimensional reduction in biology. Any leads on examples and materials to inspire would be great! The audience is mostly biologists with varying degree of experience with math/stat. Please RT
One of the things I learnt from
@arjunrajlab
is to avoid acronyms in manuscripts whenever possible as they are additional cognitive burden. Amazing how such little writing nuggets all contribute to compelling and clear writing.
🎉Congratulations to the 2024
#CZBiohubCHI
Investigators! The cohort of 48 of Chicago’s most creative and accomplished scientists and engineers will use multidisciplinary approaches to understand inflammation and the dysregulation of immune cells.
Happy to share our new preprint (my first) from
@arjunrajlab
with
@SchuhLea
"Gene networks with transcriptional bursting recapitulate rare transient coordinated expression states in cancer"
A tweet thread coming soon from the first author
@SchuhLea
Excited to be a part of the 2021 cohort of STAT Wunderkinds
@statnews
. Grateful to my colleagues and mentors for nominating me! Thanks Eric Boodman from STAT for this wonderful writeup on my journey and work
2018 Fellow
@YogeshGoyallab
shares lessons and insights from his interdisciplinary journey and now his scientific ambitions from his own lab as Assistant Professor
@NorthwesternU
. Read his full case study here:
Excited to have this review/perspective out today on how dynamical models and computational tools facilitate building predictive frameworks of non-genetic variability in cancer. Great collaboration with
@mkjolly15
@MaalavikaP
Emilia Hojel at
@NUSynBio
@NU_CDB
@NUFeinbergMed
In a recent Review,
@yogeshgoyallab
and colleagues discuss how computational tools can be leveraged to gain insights into the origins and nature of non-genetic heterogeneity in cancer.
👉
Returning from my first ever conference (in Telluride) after starting my lab organized by Vadim Backman and Martin Aryee. What a wonderful conference it was -- met several amazing researchers! Lots of great science discussions on chromatin, transciption, plasticity and beyond
The lab has collectively decided to have a meme for each paper that we publish. Lots of learning during the process together with
@vipulshukla08
! And my first PhD student
@EmanuelleGrody
co-leading this with Ajay.
Perspective on tumor clonality is out now! We cover the past, present, and future of this field, from the molecular to systems scale. Could not have been possible with my amazing co-authors
@ajayabrams
@vipulshukla08
@yogeshgoyallab
Find it here:
We are looking to hire a Research Technician in our new lab! We are located at Northwestern University in the beautiful city of Chicago. Please get in touch with me directly via email if you're interested.
@NU_CDB
@NUSynBio
@NUFeinbergMed
Help spread the word.
It was wonderful to present our latest work at the annual meeting of NSF-Simons Math-Bio institute at the Flatiron Institute in NYC! Also enjoyed meeting several other q-bio folks!
Assistant Professor Yogesh Goyal (
@yogeshgoyallab
) presented work on tracing the origins, nature and manifestations of single cell variations in response to a variety of cytotoxic chemotherapies and targeted therapies in various cancer models at the 2024 NITMB Annual Meeting
I was recently processing reimbursement for a lab visitor and was reminded of a visit during my own postdoc search for which I never got reimbursed after many reminders. Students often run on tight budgets (I certainly was) and PIs should ensure reimbursements are processed asap
Schmidt Science Fellow
@yogeshgoyal03
@Penn
wants to understand the fundamental mechanisms that allow some cancer cells to become drug resistant. Watch his inSPIREd talk to learn more about how understanding this process could lead to new treatments -
We are thrilled to welcome many Fellows and friends to Boston and Cambridge this week - starting with the Global Meeting for our 2021 Fellows hosted by
@MIT
and
@broadinstitute
. Welcome!
Super excited to present my latest
#SciArt
article (free to read) with
@lianzhu_1
in the art magazine
@_margfoundation
. We discuss why this is a critical time for artists and scientists to work together as we get inundated with data
@Sci_Art
@ArtBioCollab
Super excited and grateful for the opportunity to present my postdoc work with
@arjunrajlab
at the
@SchmidtFellows
inSPIREd event! The screen was 3 times anything I had ever seen before. My curious friend/electronics researcher
@XiwenGong
went on to count the Pixels ~33 million!!
New insights into drivers for mutation in cancer cells and how this affects drug resistance.
@yogeshgoyal03
explains for
#inSPIREd
why treated cancer can come back and how fundamental biology is helping us to understand what is happening.
#SchmidtScienceFellows
Very excited to share this project from
@yogeshgoyallab
and
@nico_bodkin
(who is in the Goyal lab), on the the prevalence of transcriptional adaptation and some possible regulatory constraints 1/
Incredibly happy with the effort driven by my brilliant students
@EmanuelleGrody
and
@SubiaAhmed06
to make the lab sustainable. Being the first lab
@NorthwesternU
to be certified came as a pleasant surprise! And I ❤️ the picture they chose for this story.
We have a faculty position in Quantitative/Systems biology in our department at Northwestern. I am having a blast here with the most supportive Chair, colleagues, and research enviornment. Please RT/spread the word! Feel free to DM me with questions.
Concluding a fantastic visit to Johns Hopkins
@JHSPHBMB
hosted by my friend & melanoma expert
@VitoRebecca1
. Lot of great science, lunch discussion with trainees and dinner conversations with
@deniswirtz
@gretchen_alicea
. Also got to see my academic grand papa Yannis Kevrekedis
Now available: our mini review on why terminal patterning in fly embryo is an excellent quantitative system for studying general principles of Ras signaling in
#development
and
#disease
.
@the_Node
@___SDB___
SciTwitter: What are your favorite methods/references for doing Differential gene expression analysis on scRNASeq datasets, especially when comparing between conditions that have vastly different cell numbers?
Our department is hiring in quantitative biology!!! I started here last year and I am LOVING the mentorship and support I get. Happy to answer any questions for those applying.
As is, educational programs are on limited funding, and it doesn't help that
@SlackHQ
would penalize us for something so unreasonable. I surely shouldn't be paying 9X more than what my neighboring lab pays.
Happy to announce the DoDMRP has funded our Idea Award & Melanoma Scholar Awards focused on
#AcralMelanoma
!! This $$$ will strengthen longtime collabs with
@yogeshgoyallab
, Efie Kokkoli and my excellent crew of scientists to unravel the metastatic & Rx resistance landscapes of AM
So grateful to have had a chance to work with
@cojiberries
in
@arjunrajlab
lab. Super proud to see her defend her PhD thesis with flying colors, and now onto bigger and better things!
It is my great pleasure to introduce *Dr.*
@cojiberries
, who successfully defended her thesis yesterday! Yay!!! So wonderful to share her tremendous accomplishment with family and friends. And check out this poster with some of her beautiful art!
So satisfying to see Kei, the first ever undergraduate student i mentored, now posting this amazing paper on meiosis in c elegans. Congrats
@KeiYamaya
!!
Communicating science is central for
#SchmidtScienceFellows
to accelerate impact from their research - and Fellows aim to do this in many ways. Recently
@yogeshgoyal03
presented his science during a visit to Germany and Jina Ko took part in
@MGH_RI
Science Slam!
Big news from
@NUSynBio
- today we launch our new approach to teach
#syntheticbiology
@NatureComms
Framing
#synbio
across scales allows anyone to learn this exciting field
Integrating the societal scale promotes responsible innovation
To the future!
"Every year counts, but some more than others."
—
@yogeshgoyal03
This cake, on occasion of his 35th* birthday, courtesy of
@cojiberries
. Also,
@yogeshgoyal03
challenged me to a race, claiming he is 2x faster than me. We shall see next week.
A joy to have breakfast today with old friend
@yogeshgoyallab
and to talk at length about work and life with the
@SchmidtFellows
whose journeys in science are brave and inspiring.
Yogesh recently recommended this wonderful book, life-changing for my son. Recommend. ❤️
Thrilled to release our lab’s 1st research. Light *and* temperature sensitive tools (thermoptogenetics?) to activate cell signals, from cells to animals, led by
@WillBenman
.
Details of an unexpected journey 👇
Understanding why some cancer cells survive treatment could lead to new discoveries that help prevent tumors from resisting therapies in the first place.
Hey
@SlackHQ
, I accidentally paid corporate price for my research/educational lab at Northwestern University, and after realizing it 5 days later, I contacted you. Your staff tells me I will not be refunded for the extra 85% I paid. I would really like my $$ back.
Please help RT
Excited to launch our cloud-based image analysis platform today at ! Analyze and interact with your data, all in the browser. Follow sign-up instructions to request an account.
Wonderful to see this lovely work from
@cojiberries
@arjunrajlab
evolve over the years to its final form. Congrats to the team! Had fun contributing a tiny bit to it.
Excited to share my (first) first author preprint from
@arjunrajlab
+ Twitterless Rajan Jain lab "Cell type determination for cardiac differentiation occurs soon after seeding of human induced pluripotent stem cells"
Excellent work by my friend
@uffdaALLberries
on finding and profiling the rarest of rare somatic cells that will reprogram to pluripotency. Several cool conceptual nuggets covered in this paper.
We are thrilled to share the raise of a $75 million Series B funding round. To learn more about the news and catch up on what BigHat has been up to, check out
@MarkDePristo
and
@peytongreenside
’s interview in
@FierceBiotech
.
@yogeshgoyal03
found our recent UK Global Meeting gave him a unique opportunity to look at his science in a completely new way. Read more about Yogesh's experiences and watch our full video with more insights from the
#SchmidtScienceFellows
:
👏 Congratulations to Bridget Alsdorf, Hendrik Hartog, Yael Niv and Stanislav Shvartsman. These
#PrincetonU
faculty members will receive the Graduate Mentoring Award for their work with graduate students:
Wonderful new study by Sayantan Dutta on fluid twisters in growing fly eggs in
@NaturePhysics
. Excited for him to be spending a couple of months with my lab at
@NU_CDB
Self-organization of actively forced slender fibers (microtubules) immersed in a fluid (cytoplasm) generates coherent flow in 3D confinements (cells). Our study featured in
@NaturePhysics
shows that using large scale simulations and live imaging of fruit fly oocytes.
Just discovered (tested for n>3 cases) that a Word document, when saved as a PDF (selected for "best for printing"), gives differently sized PDFs depending on the resolution of the screen the file is open on. Ugh too many degrees of freedom.
Hey
#SciTwitter
! I am looking for historical examples of biological resistance ranging from antibiotic to cancer therapy. Any leads on landmark studies/reports would be very helpful! Please RT.
Does leadership in science differ from other fields? What's the role of a leader in speeding discovery and engaging society? Join our speakers and the
#SchmidtScienceFellows
for discussion and debate - free tickets, Monday 23 July, 16.00 BST, Oxford -
Our 2021 Fellows represent 13 nationalities, nominated by 19 institutions in 8 countries. This grows our Fellowship community to 84 interdisciplinary scientists committed to harnessing interdisciplinary science to make a positive difference in the world:
If there's one thing you have time to read this week or month, it's this work on systematically testing (& revealing limitations in) RNA Velocity which quickly became a household tool in single-cell seq field. As always from
@lpachter
-- rigorous and **fully** open source.
If you work w/ single-cell RNA-seq & are performing RNA velocity analyses, you might find this
@GorinGennady
et al. preprint w/ Meichen Fang & Tara Chari of interest. It's a deep dive into the method, and navigation of the 67 pages may be aided w/ this🧵1/
Based on my little experience of going to conferences, I see more people working on their laptop than listening during talks. Nice blog post by
@arjunrajlab
on this observation and ways to improve based on the experience at a recent Keystone conference we both attended.
Chromatin accessibility --> gene expression? Think again, thanks to this beautifully curated and systematic analysis on a well-controlled experimental system by
@CAMBUpenn
MSTP student
@MrKarunhands
Cell systems with great papers on cellular memory this week. Glad to see
@Jeff_Mold
's paper out today. Now I need to see what more has he added in the last two years or review process.
Paper is out today! Took 2 years. Cell Systems was great review process all around. Spent some time at Science but editor quit mid-review and one reviewer didn't see the point 'we know cells have memory, is it just that this shows more of it?!'
So excited to share the published version of our paper on a cool property of transcription factors that help maintain cell identity! (now rewritten and with more experiments, analyses, and background)
Presenting an inspiring line-up of speakers across disciplines (math modeling, oncology, single-cell biology), geography (4 countries), gender for our session on quantifying/modeling cell-state transitions in cancer progression & treatment: MS18/19-ONCO.
@smb2021
@SMB_MathBiology