As
#UKRIFLFs
navigating travel w/ caring responsibilities myself
@DrLauraWolz
&
@CarterL_J
are calling for accelerated change - sharing insights into challenges faced highlighting personal experiences & proposing a strategy for institutions
@NatureCareers
Huge thanks to
@britsocimm
for the carer grant to facilitate this little scamps first
#immunology
conference … think he’s a huge fan!
… any difficult questions at
#BSI22
P103, he’s got them covered 😂
Perseverance really does pay off!!
Before the lab launched I’d been working on how myeloid cells can shape the identity and function of CD8
#Tcells
in the
#liver
…& yes it was in review for 4 years! 🤯🤯
🎉ERC Starting Grant competition results are out!
Over €619 million for the best ideas of young leading researchers - and the 1️⃣st set of grants awarded under 🇪🇺
@HorizonEU
.
Find out who, where and why 👉
#EUfunded
#FrontierResearch
#ERCStG
Can’t wait to move into our new home at the
@iit_ucl
- so watch this space as I’ll be recruiting soon.
If you are interested in liver immunology, T cells, fibrosis or even just keen to learn new things get in touch ☺️☺️
We have funding for a
#postdoc
on a super cool project imaging the human liver & furthering our understanding of tissue-resident
#Tcells
... is anyone looking? Pls do get in touch 😃😃
We're a super friendly group, growing in size constantly & in the
@iit_ucl
in London!
CD8+
#Tcell
'stemness' & IL-33 in chronic viral infection:
-IL-33 drives expansion & stem-like function of CD8s
-IL-33 prevents loss of Tcf-1
-IL-33 impacts CD8 'stemness' through epigenetic modelling, balancing the antiviral ‘‘danger’’ response of IFN
🥼 Postdoc job alert - come join us!🥼
We're looking for a postdoc to interrogate the localisation & zonation of liver
#Tcells
, and how they interact w/ neighbouring cells using high dimensional imaging technologies - is this you!?
-
Apply by 20/2/24
It’s great to be in Cape Town for such a momentous
#IUIS23
(first time it’s been held in Africa 😊) and to have the opportunity to share a small piece of our work
@iuis_online
and to extend our network
I have an amazing team
@iit_ucl
, but I’ll let them introduce themselves ⭐️
Tissue-resident memory-like NK cells (NKRM)
- recruited in CX3CR1-dependent manner post CMV infection
- long-lived & memory-like
- prevent autoimmunity via TRAIL-dependent elimination of CD4+ T cells
- modulate inflammation & preserve tissue health
Congratulations to Dr. Laura Pallett (
@ljpally19
) at
@ucl
for being selected as an IUIS Rising Star to be honored at the 2023 IUIS Congress. Learn more about her research!
Register for
#IUIS2023
to hear from Dr. Pallett & the other 14 early investigators chosen.
Pallett lab is starting to take shape!
Welcome to
@george_e_finney
the 1st postdoc to join the team & a “best of luck” to
@StephyKucyKousa
as she embarks on her PhD, alongside her tech role
Missing from photo is our new tech
@BrownRom1
(Oh & the new generation in Baby Max 🥰)
That’s a wrap on
#BSI22
, it’s been a wonderful congress with the lab taking in all fantastic immunology from across the board
Looking forward to
@bsicongress
in Belfast for
#BSI23
Massive congratulations to
@Leo1401j
for his Wellcome Career Development Award...a whole EIGHT years of funding to expand his fantastic research group
@iit_ucl
🤩👏🍾🥂🍾
We're really proud of postdoc
@george_e_finney
!!
He's been awarded a
@britsocimm
Career Enhancing Grant to spend time w/ Ramachandran group (
@prakramacha
) taking on board new skills & as much knowledge as poss to help us understand the liver niches & how it impacts
#Tcells
🙌🙌
📣Announcing the winners of the latest BSI Career Enhancing Grant round!
Congratulations to our 11 members who have been awarded
#funding
to advance their
#CareerDevelopment
!
Discover the projects we're supporting to boost
#CareersInImmunology
👉
1/2
Have you read
@Nature
article “Researcher parents are paying a high price for conference travel - here’s how to fix it” ()
Now meet the 3 scientists all called Laura behind it (L👉R)
AstroLaura
@DrLauraWolz
ImmunoLaura
@ljpally19
EnviroLaura
@CarterL_J
📣A topical review, with a topical title📣
Mala
@maini_lab
& I thoroughly enjoyed writing this review on all things tissue-resident T cells that "live a life in lockdown" in the
#liver
, covering how they are retained & adapted.
Hope you enjoy it too!
COOL PAPER ALERT! - estimating number, mass & distribution of immune cells in humans
Humans have ≈1.8×10^12 immune cells weighing ~1kg!!!
Lymphocytes ≈15% of immune cells <200g
Fig: Distribution of immune cells in diff tissues (each square =10^9 cells)
Hey
#BSI21
community - the Pallett lab has recently fledged within the
@iit_ucl
.
Give us a follow for T cell, stromal cell and the highs/lows of starting a lab - related content
@pallett_lab
Oh and we also have a postdoc job position going live v v soon -
@britsocimm
Love my team 💚⭐️💚
Come hear me present tomorrow morning at
#IUIS2023
in the TB OR NOT session at 8:45 🙌🙌
An usual education imprinted on resident T cells
Hear from members of Rising Star Dr. Laura Pallett (
@ljpally19
)'s lab! She will be giving a talk on "Myeloid cell instruction of liver-resident T cells" tomorrow, Tuesday, 28 Nov, 10:00 - 10:15 SAST in Auditorium I.
Check out our full
#IUIS2023
program:
My fellow
#Rising
⭐️ awardees from all over the globe - working on a huge range of things from host-pathogen interactions to the intricacies of the antibody repertoire to vaccination vs natural infection
#IUIS2023
@iuis_online
@iuis_junior
…& what a fabulous group of people
Meet our new PhD students👏
They've all been working in our wider group in some capacity over the last yr - so ALREADY have an enormous amount of talent, amazing ideas & oodles of potential
From all of us - we wish you every success & hope the experiment gods are on your side😆
The lab are heading to Liverpool! Everyone’s excited for a packed 4 days at
@bsicongress
!
If you want to find out how liver CD8 T cells are reprogrammed by myeloid cells, come find me at poster 103 😁
#BSI22
Fantastic time at
#IUIS2023
, lots of great discussions scientifically, but perhaps most important … what a stunning country 💚
Onwards to
#BSI23
, via an afternoon of wine here in SA 😉
🚨JOB ALERT🚨
Are you looking for a
#postdoc
? Come adventure with the
@maini_lab
in the
@iit_ucl
investigating
#Tcells
in chronic HBV infection & liver cancer.
I can not recommend the
@maini_lab
more 😊 a fantastic, supportive and fun group
APPLY NOW
Excited to share that the
@London_immuno
Group has been working hard behind the scenes to bring you our 2024 annual meeting - this time ....
VISULISING IMMUNOLOGY!!!
Save the date: 12th July
Location: Central London
New event: BSI
@London_immuno
Group's 'Visualising
#immunology
' 🌠
This one-day meeting will bring together expert speakers & provide
#ECRs
with the opportunity to present & discuss their work 🤩
#VisualisingImmuno24
Save the date & find out more 👉
As promised below…
📌 JOB ALERT!
Our postdoc job advert has gone live! Get in touch, share, RT and spread the word. Come join the
@pallett_lab
in the
@iit_ucl
to work on liver immunology ☺️☺️
Hey
#BSI21
community - the Pallett lab has recently fledged within the
@iit_ucl
.
Give us a follow for T cell, stromal cell and the highs/lows of starting a lab - related content
@pallett_lab
Oh and we also have a postdoc job position going live v v soon -
@britsocimm
Hi everyone ! My name is Alexia and I’m a summer intern at the Pallett lab. I’m taking over this account for the next couple of weeks so stay tuned for some fun behind the scenes 👩🔬🧫
Effector-committed
#Tcells
, but not memory-committed Tcells are vulnerable to pyrimidine nucleotide starvation, with memory
#Tcell
precursors able to upregulate pyrimidine synthesis capacity
Closing out
#BSICamridge23
with fascinating work on Tim3 and certain ‘dark kinases’ within the PI3K family and their anti-tumour responses from
@KuchrooLab
Featuring also a wonderful T cell based poem 😂
Laura is presenting her
#BSI22
poster tonight …
‘Tissue CD14+CD8 T cells are reprogrammed by myeloid cells and modulated by LPS’ (except it may or may not have a different title on the printed version 😂🤦🏼♀️😂)
P103 - come say hi 👋
PS if you dislike babies, stay away! 😂😂
Finishing a BSc/MSc this yr & interested in
#immunology
research?
Looking for a
#technician
job in experimental immunology?
Along w/ the
@maini_lab
@iit_ucl
we'll be
#hiring
a Research Tech to helps us understand immunity in the human liver
⏰25 Apr
Happy Chinese New Year from *ALL* of us!
Let’s hope the year of the 🐉🐉🐉 brings you courage and strength in those science-related challenges!
Being out celebrating with the Maini (
@maini_lab
), Swadling (
@Leo1401j
), Zhuang, Fink and Lee (
@BeckiLee
) labs was so much fun!
It's so disappointing to still be seeing "unfortunately we aren't able to cover childcare costs" for [invited] speakers at conferences.
C'mon academia we can surely do better to support carers?
Absolutely amazing spread at “The Great Br(IIT)sh Bake Off”. Huge congratulations to everyone involved.
#ScientistsWhoBake
Including our very own
@george_e_finney
efforts - stellate-Tcell crosstalk in cake form!
Have you registered for the
@EMBO
Tissue Resident Immune Cells in Health and Disease, 20-23 March 2024, Marseille, France.
The abstract deadline has been extended to 15th Feb, slots still available for short talks. So get applying!
Take a note of the key dates announced for the European Congress of Immunology (ECI) 2024!
The 7th ECI will take place in Dublin from 1st to 4th September, 2024.
Visit the link to learn more!
The cat is out the bag....
@george_e_finney
will be joining us as
@UKRI_News
funded postdoc in the Pears Building
@iit_ucl
this summer!!
Watch this space as I'm 100% sure good things will happen!
Welcome on board George 🧑🔬🥼🧪🥼🧑🔬
Super excited to be announce that I’ll be joining the
@pallett_lab
this summer as a postdoc at
@UCLInfectImm
!! 🥳 Just the thesis to finish now…
Here’s to more T cell-stromal cell interaction research 🧫
Proud of the
@London_immuno
group (especially our two ⭐️’s) who today engaged with policy makers
@HouseofCommons
on issues pertinent to scientific careers, retention of talent, visas and how we address vaccine hesitancy 🎉
It was an absolute pleasure to represent
@britsocimm
at today's
@RoyalSocBio
#VOF24
& ask our science policy questions to MPs & Lords at the
@HouseofCommons
🤩
We discussed public engagement to improve vaccine hesitancy, longer-term funding to attract & retain int. scientists...
Excited to announce that we’ve started as we mean to go on with a 2022 SILVER
@LEAFinLabs
sustainability award for our space in the
@iit_ucl
@UCLInfectImm
that opened in November!
♻️👏♻️
Now we work towards GOLD for 2023!
New
@DonnaFarber3
group study using a fantastic cohort of mucosal & lymphoid tissues from paediatric *human* donors (upto ~10yrs old)
👶
#Tcells
preferentially accumulate in mucosal tissues early in life
👶TRM undergo functional maturation over childhood
We were the last ones standing (well seated!) from the joint
@maini_lab
&
@pallett_lab
picnic last night to celebrate many many achievements 🥳
Amazing to get everyone together!
We’re all here for
#BSI22
, come find us and say hi … especially if you love talking T cells, tissue residency, liver immunology or even immunometabolism and our new love, stromal immunology
🙋♀️🙋🙋♂️
The BSI Edinburgh Immunology Group finally returns for the new year with a seminar by
@pallett_lab
. Thanks for braving the storm travel to tell us all about liver resident T cells!
#dayinthelife
Pallett lab intern 👩🔬Lab meeting this week was centered around
@gpistocchi_
presenting her data on the heterogeneity of hepatic tissue resident T-cells. Let us know whose day you want to see next!
Really looking forward to going through the postdoc job applications I've received over the next few days
😀😀😀
It's fantastic that people have taken the time to show interest in the lab! 🥰🥰🥰
At a lose end this Twixmas?!
Why not consider applying for a
#postdoc
position with us,
@pallett_lab
, part of
@iit_ucl
.
We are looking for someone interested in studying resident T cells, liver immunology and/or how cells communicate with each other!
Some absolutely great questions and discussions have already started after my talk here at
@iuis_online
#IUIS2023
🎉🎉🎉 looking forward to what comes next with our work on CD14 T cells in tissues across the body!
Thanks to
@AljawharahAlru1
for the photo 😊😊
Huge congratulations to Dr (Dr) Nathalie Schmidt
@natha_schmidt
- thoroughly well deserved. We all enjoyed celebrating with you…🎉🎉🎉
@george_e_finney
great work on the cake!
Now my new position as Group Lead (
@ucl
) is official does anyone have any top tips, any do's or any dont's to get the lab started???
#NewPI
#AcademicTwitter
It was great to have Haadiyah, Anisa and Zahid, three
@in2scienceUK
students, in the lab over the last few days. Real bright sparks and asking very good questions!⚡️
Wishing them the best on their studies and doctoral aspirations 👩⚕️👨⚕️
Well done to
@StephyKucyKousa
&
@KaneFos
presenting in our internal meeting this morning - wouldn’t normally shout about internal meetings but was so nice to see our current PhD student present alongside our old MSc student who is wrapping up a project in a different group 🙌🙌🙌
🚨WE ARE HIRING🚨
Are you a recent MRes/MSc/BSc graduate looking for your next fun adventure?
We are looking for Research Technicians to come join us here in the
@iit_ucl
in the wider group we share w/ the
@maini_lab
Please apply & share widely!
Huge congratulations to
@AnnaJS_viro
- the news is official now as the PhD hat has been donned 😉
From all of us - we wish you the very best of luck with what is coming next, remember you can now never leave the group!
(Thanks for
@BrownRom1
& Joe for their hat making skills!)
Happy "International Day of Immunology" to all our lovely lab friends, collaborators, colleagues, social media followers, and immunologists in the making.
#worldimmunologyday
#Immunologyday
Don't miss your chance to submit an abstract (or 2) to present at this meeting. We have a fab line-up for you inc.
@DonnaFarber3
TBC
@Taams_Lab
inflammed joints & Tcells
@McGovernLab
epigenetics & macrophage
@LabListon
Tregs in tissues
@StridLab
epithelial immune surveillance
🆕 BSI
@London_immuno
meeting! ✨
#TissueImmunology2023
Bringing together speakers with expertise in the
#immunology
of different tissues to advance the field ⏩
Join us on Friday 7 July in London 📍 Abstract submission & registration is now open!
Sending off our summer student, Alexia, before her year studying in Boston - she’s been a great asset to the team and wishing her the very best on her studies abroad 🇺🇸😁
The outcome of
#Tcells
& myeloid cells interacting in the
#liver
is a T cell capable of superior effector function when stimulated through its T cell receptor *but*...able to switch function (chemotactic/regenerative mediators) in the presence of bacteria
🚨PhD studentship programme - going live soon🚨
CRUK's 4-yr PhD programme will open for applications soon - a unique multidisciplinary & collaborative training opportunity!
& the best bit
@SchurichLab
& I have proposed a project: T cells in liver cancer
Huge congratulations to my brilliant colleague Mariana Diniz on her latest paper in
@NatImmunol
Punchline: Tissue-resident CD4+ and CD8+ T cells able to cross-recognise SARS-CoV2 detectable in the human airway
👏👏
Review out now in
@NatImmunol
from Mallar Bhattacharya & Prakash Ramachandran (
@prakramacha
) discussing recent advances in the understanding of fibrosis in humans, with a focus on immune cell profiles & functional immune–stromal interactions
Absolutely delighted to have been drafted in as an emergency co-chair for a session at
#BSI23
@bsicongress
🙌
Congress is a firm-favourite of ours ... What sessions will you be attending? Who will we see there?
Come say hi! 🙋♀️🙋🙋♂️
🚨Glutamine as an intercellular metabolic checkpoint - work from
@hongbo_chi
's group in
@Nature
Supplying enough glutamine directly to tumors promotes cDC1 activation of CD8+Tcells inhibiting tumour growth
*ALL despite tumor cells gobbling up glutamine!
Delighted with my ‘carer grant’ to attend this years
@britsocimm
Congress! Can’t wait, and my wee man gets to experience his first immunology conference 😭😊
Lineup looks great - inc our *big* ‘in press’ paper as a poster presentation 😉😉😉
Have you seen the
#BSI22
programme? Highlights across the 4 days include:
⭐ Keynote presentation from Dr Gitta Stockinger
@TheCrick
⭐ 6 plenary sessions
⭐ 25 parallel sessions
⭐ Bright Sparks in
#Immunology
Check it out & register now! 🔗
Evaluating the safety & immunogenicity of the therapeutic vaccine ChAdOx1-HBV designed to induce functional cure in patients living w/ chronic HBV
💉safe
✨immunogenic in controls (high magnitude cross-reactive
#Tcell
responses)
At a lose end this Twixmas?!
Why not consider applying for a
#postdoc
position with us,
@pallett_lab
, part of
@iit_ucl
.
We are looking for someone interested in studying resident T cells, liver immunology and/or how cells communicate with each other!
In
@ScienceMagazine
the
@LMackayLab
confirm that not all TRM are equal!
The 'usual suspects', the CD8+ TRM1, IFNg+ antiviral/antitumour guys, acquire residency differently from CD8+ TRM17 (IL-17+) which contribute to antibacterial immunity & wound-healing
It was such a pleasure to be part of the
@LondonPostdoc
#CareerAdvice
discussion panel 🗣️
So many great questions for such a diverse panel in all areas of science 🧪
(2/2)
We’re also excited to share news of our funded project (
@FLFDevNetwork
) to investigate the scale of the problem & to gather evidence to deliver a set of recommendations & suggestions for funders & institutes to support those balancing caring and career
#carersinstemm
This mornings activity = coffee & snacks while putting slides together for
#IUIS2023
@iuis_online
👩💻
I'll be presenting in the 'TB or NOT: Immunity to Bacteria' session TUESDAY a.m. after our keynote from Emmanuelle Charpentier 🙌
DON'T MISS IT!!
(I've changed my title tho 🫢)
Along with our
@London_immuno
friends, some of the
@pallett_lab
will be at Kings Cross Station today to chat to members of the public about all things immunology & vaccines 🧑🔬👨🔬👩🔬
Come say hi!
I’m joining the careers panel at this fantastic event on Tues…
#NewPIs
…what was the 1 thing you didn’t expect when becoming a PI?
What do you most enjoy about your job?
If you could do anything else, what would it be?
Pls RT so I can share wider views than just my own
Looking forward to presenting at this meeting tomorrow in sunny Southampton - we will be sharing a few small snippets of unpublished (
@george_e_finney
's data) & published data showing how fibroblasts of the liver can orchestrate our favourite cell - 💚resident T cells💚
Looking forward to spending the day in Birmingham with the
@BSI_Midlands
Immunology Group (thanks for the invite
@SarahDimeloeLab
) - catching up with some friends & colleagues, and meeting some new faces 😊
Our postdoc
@george_e_finney
is attending the
@EMBO
workshop on tissue-resident immune cells in health & disease this week in sunny Marseille! We're not jealous at all!
Who else is attending? Go say hi!
Morning marathon training done ✅
Now ready for the first day of
@EMBO
Tissue Resident Immune Cells in Health and Disease conference in Marseille 🇫🇷
Very excited to present our work from the
@pallett_lab
later this week ☺️
Looking forward to presenting at this meeting on Friday 😀😀😀
Have you signed up yet? Still time to grab a ticket to join us at the Holiday Inn in Bloomsbury to hear all about Tissue Immunology
Have you registered? 🙋♀️🙋🙋♂️