Mario Kratz @mario_kratz Twitter profile | Pikagi

Pikagi

Mario Kratz

@mario_kratz

4,379

Followers

1,139

Following

119

Media

1,858

Statuses

Nutrition & Chronic Disease Researcher | Creating Content About Nutrition and the Prevention of Chronic Disease | Founder & Director @ Nourished by Science

Seattle, WA

https://t.co/D6XoTIVQZr

Joined December 2015

Don't wanna be here? Send us removal request.

Pinned Tweet

@mario_kratz

Mario Kratz

3 years

I am excited to announce the launch of Nourished by Science, a new website and YouTube channel dedicated to the highest standards of scientific rigor in communications about the links between nutrition, health, and chronic disease.

Tweet card media

Welcome to Nourished by Science

In this video, I would like to introduce you to the new Nourished by Science YouTube channel. My goal is to provide thorough, unbiased, evidence-based inform...

www.youtube.com

16

29

247

Last Seen Profiles

@HundLab

@matthewbowker

@TotalKroos

@Inaya786khan

@curlyQgoddess

@skip2mylizzle

@Joururi_ws

@yawaragikansai

@fabulouscerti

@demi_jord

@fum3k5l

@Laser2000GmbH

@RitchieMulligan

@stwmaniax

@Rafin_emolover

@forthpcsp

@DmitriyReznikov

@Caimbra_nsfw

@DatBOYReyley

@skypocyo

@TalemonSoft

@RaceStupid

@ainmwwww

@buzzbishop

@1Revorimit

@BAAGI1030

@LHCultura

@behal_beh

@sy00b

@hammernutrition

@RonWLATimes

@dobetterdnvr

@evornithology

@milasconpure_

@Vedha_TN

@vetro09

@mario_kratz

Mario Kratz

2 years

In the 1970s the dietary guidelines in the US started recommending a low-fat, high-carb diet. One argument often made is that the resulting increase in carb consumption triggered the obesity epidemic.

Tweet media one

22

83

352

@mario_kratz

Mario Kratz

8 months

Lipids such as triglycerides or cholesterol need to be packaged for transport in the blood. These transport vehicles are called lipoproteins. There is a lot of confusion about the different types of lipoproteins, so let's discuss the basics of lipoprotein metabolism. 🧵

Tweet media one

9

85

356

@mario_kratz

Mario Kratz

8 months

Lowering LDL-cholesterol reduces the ABSOLUTE risk for a CVD event only minimally. From this fact, some people conclude that LDL-cholesterol is not an important risk factor for atherosclerotic CVD. IMO, that conclusion is poorly conceived.

Tweet media one

31

49

191

@mario_kratz

Mario Kratz

1 year

Many authors of social media posts and even nutrition books seem to think that "evidence-based" means that you can make the statement "X causes Y" as long as you can cite one paper to support that statement. What this leads to is a situation like this:

Tweet media one

7

36

182

@mario_kratz

Mario Kratz

4 years

@MicrobiomDigest The one thing I object to is doing tons of reviews and editorial board duties for free, and then getting charged $2,000 in publication fees by those same journals for my own papers, some of which I have to cover out of pocket. Something about this feels very wrong.

4

17

145

@mario_kratz

Mario Kratz

8 months

A common claim online is that only small, dense LDL particles are atherogenic, and that large, buoyant, or "fluffy", LDL particles can safely be ignored. What is all of that about? What does the scientific evidence say? A 🧵 #ldl #ASCVD #CVD #atherosclerosis #lipoproteins

Tweet media one

11

33

148

@mario_kratz

Mario Kratz

2 years

There is a common narrative on social media that lower blood sugar levels are always better, and that sugar spikes after a meal should be avoided like the devil.

Tweet media one

10

14

130

@mario_kratz

Mario Kratz

9 months

@realDaveFeldman @BudoffMd Super interesting. It's early days, and a small cohort, but I feel that this line of work promises to teach us something new about the relationship between LDL-cholesterol/apo B-containing particles and ASCVD. Even though it's just the baseline data, given that participants

7

9

121

@mario_kratz

Mario Kratz

2 years

A new video is out wrapping up our discussion of the link between ultra-processed foods, overeating, and the obesity epidemic. Features an RCT by @KevinH_PhD , and practical tips we can learn from this work to minimize overeating. via @YouTube

Tweet card media

Ultraprocessed Foods: The #1 Cause Of Overeating And Weight Gain?

In this video, we will review evidence strongly suggesting that ultra-processed foods may be a major cause of overeating and weight gain.- SUBSCRIBE TO THE C...

www.youtube.com

8

27

91

@mario_kratz

Mario Kratz

6 months

Energy density is a crucial factor that is often not given enough attention despite having a significant impact on ad libitum energy intake. Energy density is simply the calorie content of a food, meal, or diet per g (or per 100g).

Tweet media one

16

19

93

@mario_kratz

Mario Kratz

1 year

On the population level, the body mass index and body fat mass are strongly associated with insulin resistance and an increased risk of type 2 diabetes. For example, the graph below is based on data from the Nurses' Health Study:

Tweet media one

6

23

82

@mario_kratz

Mario Kratz

7 months

Recently, several influencers on X tweeted about an RCT in which patients with fatty liver disease were randomized to consume a diet rich in fruit or low in fruit. Let's discuss the results and consider them in the context of the broader literature.

Tweet card media

The effect of a fruit-rich diet on liver biomarkers, insulin resistance, and lipid profile in...

This trial was registered at Iranian randomized clinical trial website with IRCT registration no. IRCT20201010048982N1on October 15, 2020.

pubmed.ncbi.nlm.nih.gov

9

11

72

@mario_kratz

Mario Kratz

2 years

New video: The nutrition transition towards an industrialized food system rich in ultra-processed foods has coincided almost perfectly with the obesity epidemic in populations around the world. Summary of the data, and my thoughts:

Tweet card media

The Global Nutrition Transition (Why Nutrition Matters, Part B)

In this video, we will discuss the dietary changes that may be responsible for the worldwide twin epidemics of obesity and diabetes.- SUBSCRIBE TO THE CHANNE...

www.youtube.com

3

21

73

@mario_kratz

Mario Kratz

1 year

When we gain weight, our body needs to store extra fat. This could be stored in different tissues: In subcutaneous fat (just underneath the skin). In visceral fat (surrounding the inner organs). In ectopic depots (tissues such as liver and muscle not designed for fat storage).

Tweet media one

4

17

71

@mario_kratz

Mario Kratz

9 months

New video: "Blood Lipids and Cardiovascular Risk: Everything You Need to Know"

Tweet card media

Blood Lipids and Cardiovascular Risk: Everything You Need to Know

This video covers the role of blood lipids, specifically LDL-cholesterol, in atherosclerosis and cardiovascular disease.- SUBSCRIBE TO THE CHANNEL FOR MORE C...

www.youtube.com

7

13

70

@mario_kratz

Mario Kratz

7 months

A THREAD about FRUCTOSE and SUGAR-SWEETENED BEVERAGES: If we drink a beverage sweetened with high-fructose corn syrup (i.e., 45% glucose, 55% fructose), the fructose concentration in our peripheral blood stays very low. About 90% lower than blood glucose levels. Why is that?

Tweet media one

3

19

63

@mario_kratz

Mario Kratz

1 year

Recently, the excellent Nicola Guess @Dr__Guess wrote up her thoughts about blood sugar spikes and CGM use. I tend to agree with Nicola on most points, but there is one key point in which our interpretation of the scientific evidence differs. A friendly rebuttal ...

10

12

62

@mario_kratz

Mario Kratz

8 months

@NikosNoulezas @LDLSkeptic David, I have read all of your published papers related to LDL-chol and watched several of your presentations, and, respectfully, I don't find your argument convincing. And I am saying this even though I do agree with you that the evidence that LDL (or apo B-carrying particles)

8

11

58

@mario_kratz

Mario Kratz

1 year

New YouTube video: Do Carbs Cause Insulin Resistance? In the newest video, I am taking a thorough look at the scientific evidence to shed light on whether insulin sensitivity differs between low-carb and high-carb diets:

Tweet card media

Do Carbs Cause Insulin Resistance?

A common claim on social media and nutrition books is that a high-carb diet causes insulin resistance. We review whether scientific evidence supports this cl...

www.youtube.com

8

11

54

@mario_kratz

Mario Kratz

1 year

New video: Causes of Insulin Resistance: The Personal Fat Threshold Hypothesis Discusses a key concept linking excess body fat mass to insulin resistance, glucose intolerance, and type 2 diabetes.

Tweet card media

Causes of Insulin Resistance: The Personal Fat Threshold

This video discusses the personal fat threshold hypothesis, a key concept in the development of insulin resistance and type 2 diabetes.- SUBSCRIBE TO THE CHA...

www.youtube.com

8

12

54

@mario_kratz

Mario Kratz

4 years

AJCN just published the main paper of the dissertation project of @kelseyaschmidt , a randomized controlled trial of the impact of low-fat or full-fat dairy foods on glucose homeostasis.

7

20

57

@mario_kratz

Mario Kratz

9 months

@realDaveFeldman @BudoffMd Yes, the data have affected what I am going to share in the video. I had planned a section discussing common claims that LDL-chol/apo B are not important risk factors for ASCVD. One of these claims was that high LDL-cholesterol on ketogenic diets is not atherogenic. So far, this

8

8

56

@mario_kratz

Mario Kratz

3 years

Postdoc Opportunity in Clinical Nutrition Research! We have a fundable score on an R01 to study the acute effects of overfeeding on hypothalamic gliosis (in humans, as measured by MRI). PI and primary mentor would be Ellen Schur at the University of Washington.

2

17

55

@mario_kratz

Mario Kratz

9 months

Important point made here by @Paddy_Barrett . I made a similar point in my recent video, linked below. Critics of the lipid-heart hypothesis often point out that the ABSOLUTE risk reduction in lipid-lowering trials is small. While this is factually correct, it is a poorly

@Paddy_Barrett

Dr Paddy Barrett

9 months

Most people overestimate their risk of heart disease in the near term And underestimate their risk over the long term. Here is how to calculate Lifetime - Risk & Benefit 📕 Make Sure To Bookmark ✅ /1

Tweet media one

8

37

177

13

10

51

@mario_kratz

Mario Kratz

2 years

Particularly if we look globally, we see a correlation emerging between the consumption of UPFs and obesity prevalence. Specifically, obesity rates have remained low in high-carb countries such as Italy that have - so far - not adopted UPFs widely.

Tweet media one

4

4

53

@mario_kratz

Mario Kratz

8 months

I really like this editorial by @lowcarbGP One problem in diabetes & nutrition research these days is that ambitious larger-scale RCTs that investigate diet and lifestyle change for the reversal, as opposed to the management, of T2DM are usually not fundable because they are

@lowcarbGP

Dr David Unwin

8 months

1/3 Published today my first ever editorial 😊Are we getting good value from all the money spent on research into nutrition and obesity ?? Obesity rates are climbing ++so perhaps not. I suggest an alternative

Tweet media one

25

102

343

4

10

51

@mario_kratz

Mario Kratz

2 years

Maybe eating more refined carbs and sugars played a role, but we may want to consider the other tremendous changes that have occurred since the 1970s in the US (and global) food system, particularly the move towards ultra-processed food (UPF).

1

1

50

@mario_kratz

Mario Kratz

11 months

Many commenters on my YouTube videos think that developing insulin resistance takes many years or decades. This is not necessarily the case. In fact, specific triggers can cause insulin resistance in minutes to hours. It depends on which trigger we are exposed to ...

Tweet media one

4

6

47

@mario_kratz

Mario Kratz

9 months

@drpablocorral @US_FDA @EMA_News I think you misunderstand the design of the study. Participants were not enrolled in a keto diet, but were free-living people following a keto diet who happened to have a phenotype characterized by isolated massively elevated LDL-cholesterol. It's an observational cohort, and

2

1

46

@mario_kratz

Mario Kratz

2 years

UPFs are "industrial formulations of foods with typically 5 or more and usually many ingredients". They usually contain sugar or high-fructose corn syrup, added oils and fats, and a long list of "substances not commonly used in culinary preparations".

Tweet card media

Ultra-Processed Foods: Definitions and Policy Issues - PubMed

Four categories of foods are proposed in the NOVA food classification, which seeks to relate food processing as the primary driver of diet quality. Of these, the category "ultra-processed foods" has...

pubmed.ncbi.nlm.nih.gov

1

4

47

@mario_kratz

Mario Kratz

6 months

A common claim online is that high-protein diets are more satiating than low-protein diets. Is there any scientific support for this claim?

9

2

45

@mario_kratz

Mario Kratz

2 years

I am not saying that the global obesity epidemic can be entirely attributed to UPFs. In fact, the whole point of this thread is to suggest that the obesity epidemic almost certainly does not have a single cause.

2

2

44

@mario_kratz

Mario Kratz

1 year

Tomorrow, I will publish a new video and blog post about the type of body fat that is strongly linked to insulin resistance and glucose intolerance.

Tweet media one

3

5

43

@mario_kratz

Mario Kratz

2 years

@DrEenfeldt Walnuts and cashews, but particularly peanuts are a lot higher in protein. Macadamias have the highest deliciousness index though ...

1

0

41

@mario_kratz

Mario Kratz

8 months

A better way to think about this conceptually is that if we minimize exposure to all CVD risk factors, the sum of several small absolute risk reductions in the short term should amount to a very meaningful absolute risk reduction in the long term. That is what we are aiming for.

Tweet media one

4

5

41

@mario_kratz

Mario Kratz

7 months

@NutritionMadeS3 Thanks for sharing, Gil. That's a great find, and I really enjoyed reading it. The primary exposure here, the corrected insulin response (CIR) is a measure of the early insulin response, relative to the early increase in blood glucose. The early insulin response (first 30

6

5

40

@mario_kratz

Mario Kratz

6 months

Highly recommend this new video by Gil, even if you are not interested in the particular influencer named in the title. This is a very important, and well presented, discussion of some of the key problems in science communication on social media and in nutrition books. Gil

@NutritionMadeS3

Gil Carvalho MD PhD🌈

@NutritionMadeS3

6 months

A critical look at Dr. Gundry´s communication style and how story-telling based content is. structured and confuses the public

17

13

120

4

2

37

@mario_kratz

Mario Kratz

6 months

New video alert: "Keys to a Healthy Body Weight: Maximize Satiety per Calorie" Discusses three key characteristics of highly satiating foods/meals.

Tweet card media

Keys to a Healthy Body Weight: Maximize Satiety per Calorie

A key to a healthy body weight is to maximize satiety per calorie in our meals. This video covers the why and how of this approach.- SUBSCRIBE TO THE CHANNEL...

www.youtube.com

4

6

38

@mario_kratz

Mario Kratz

1 year

High-carb foods such as grains and potatoes are staples of most people's diets. However, some people are concerned that eating these foods could give them a blood sugar spike. Here are 6 evidence-based strategies to avoid a blood sugar spike when eating a high-carb meal.

Tweet media one

3

8

34

@mario_kratz

Mario Kratz

2 years

However, I suggest we are careful with oversimplified statements that blame the carbs for everything the UPFs, and likely numerous other dietary factors, at least contributed to.

2

1

35

@mario_kratz

Mario Kratz

2 years

If we consider the time since 2000, however, when obesity prevalence has again almost doubled, there has been no significant change in the relative proportion of calories eaten as carbs vs. fat. See Fig 1 in this paper here:

Tweet card media

Trends in Dietary Carbohydrate, Protein, and Fat Intake and Diet Quality Among US Adults, 1999-2016...

From 1999 to 2016, US adults experienced a significant decrease in percentage of energy intake from low-quality carbohydrates and significant increases in percentage of energy intake from high-qual...

pubmed.ncbi.nlm.nih.gov

1

2

34

@mario_kratz

Mario Kratz

2 years

If we compare low-UPF diets either high or low in carbs, as in DIETFITS, we find that both lead to similar weight loss. This is inconsistent with the idea that the carb content of the diet is the primary determinant of energy intake and body weight.

Tweet card media

Low-Fat vs Low-Carbohydrate Diet on Weight Loss in Overweight Adults

This randomized clinical trial compares the effects of a healthy low-fat vs a healthy low-carbohydrate diet on 12-month weight change among adults aged 18 to 50 years with a body mass index of 28 to...

jamanetwork.com

2

1

33

@mario_kratz

Mario Kratz

9 months

@drpablocorral @US_FDA @EMA_News @drpablocorral , no, I understand this concept very well, and my response to you was not to question the relevance of apo-B-carrying particles for ASCVD. My point was an ethical one: if people freely choose to adopt a ketogenic diet, for - on average - 4+ years, and obviously

2

0

31

@mario_kratz

Mario Kratz

5 years

New review paper on low-fat vs. full-fat dairy effects on adiposity and cardiometabolic disease risk biomarkers out in Advances in Nutrition today.

0

8

32

@mario_kratz

Mario Kratz

10 months

"I must have watched literally 100s of nutrition and health videos over the last 5 years and this is without doubt the absolute BEST. Clear, well explained with no food tribe drama. [...]" Comment on this YouTube video:

Tweet card media

Causes of Insulin Resistance: The Personal Fat Threshold

This video discusses the personal fat threshold hypothesis, a key concept in the development of insulin resistance and type 2 diabetes.- SUBSCRIBE TO THE CHA...

www.youtube.com

5

1

30

@mario_kratz

Mario Kratz

2 years

Among healthy people with normal glucose tolerance who have blood sugar in the 70-140 mg/dL range much of the day, however, there is little evidence that they benefit from 'optimizing' their blood sugar levels further. Any potential benefit in that group is also likely small.

3

4

30

@mario_kratz

Mario Kratz

2 years

New video and blog post out: The Regulation of Blood Sugar! We cover: - How our bodies regulate our blood sugar levels - What goes wrong in these processes if we develop diabetes - How to interpret lab results related to blood sugar - How diabetes is diagnosed

3

7

30

@mario_kratz

Mario Kratz

2 years

Continuous glucose monitors, or CGMs, have traditionally been used by people with diabetes, but have recently also become popular among healthy people with normal glucose tolerance.

Tweet media one

3

4

30

@mario_kratz

Mario Kratz

1 year

A new nutrition book has just been reviewed by @redpenreviews ! Of the books we have reviewed so far, this is the highest-scoring book that recommends a low-carb diet. The primary reviewer was the very talented @SamuelDickenUK

@redpenreviews

Red Pen Reviews

1 year

Just published: Our review of Fast 800 Keto: Eat well, burn fat, manage your weight long-term By Michael Mosley Reviewed by @SamuelDickenUK

Tweet media one

3

7

36

3

7

30

@mario_kratz

Mario Kratz

1 year

That Nature Medicine paper claiming to link dietary erythritol to cardiovascular events! A lot has been said and written about it, but I still feel compelled to share some thoughts. A thread about why the paper should not have been published like this.

Tweet card media

The artificial sweetener erythritol and cardiovascular event risk

Nature Medicine - Metabolomics analyses reported an increased risk of cardiovascular disease associated with the artificial sweetener erythritol, supported by mechanistic studies showing that high...

1

10

31

@mario_kratz

Mario Kratz

8 months

Fourth, I suggest we often think about chronic disease risk factors incorrectly. The risk of a CVD event is not determined by the current exposure to that risk factor (i.e., our LDL-cholesterol level today), but by our cumulative lifetime exposure to the risk factor.

1

0

31

@mario_kratz

Mario Kratz

1 year

Citing 1-2 papers that support our claim while not considering or mentioning those that don't is almost as bad as simply making up stuff. Maybe even worse, because citing papers gives the appearance that a claim is based on evidence.

1

2

30

@mario_kratz

Mario Kratz

2 years

That's a wrap! If you enjoyed this: 1. Follow me for more content on nutrition as it relates to the prevention of chronic disease. 2. Like and/or share this with your audience.

@mario_kratz

Mario Kratz

2 years

In the 1970s the dietary guidelines in the US started recommending a low-fat, high-carb diet. One argument often made is that the resulting increase in carb consumption triggered the obesity epidemic.

Tweet media one

22

83

352

6

3

29

@mario_kratz

Mario Kratz

4 years

A new book review on RedPenReviews is out! I reviewed ‘Eat Right 4 Your Type’, the popular book about blood type diets. 1/8

Tweet card media

Eat Right 4 Your Type expert review • Red Pen Reviews

Eat Right 4 Your Type argues that our blood type should determine which foods we eat. Is it evidence-based?

www.redpenreviews.org

5

9

29

@mario_kratz

Mario Kratz

1 year

New blog post and video: "How to avoid blood sugar spikes, without reducing carbohydrate intake." Covers six evidence-based strategies that reduce the postprandial increase in blood sugar levels after eating.

Tweet card media

How to Avoid Blood Sugar Spikes (Without Reducing Carb Intake)

In this video, we are discussing six evidence-based strategies that lower the blood sugar response to a meal to avoid blood sugar spikes.- SUBSCRIBE TO THE C...

www.youtube.com

4

6

29

@mario_kratz

Mario Kratz

2 years

Are you clear on how to interpret lab data related to blood sugar regulation, such as fasting glucose, HbA1c, or data from an oral glucose tolerance test? If not, this video here will answer all of your questions:

Tweet card media

Regulation of Blood Sugar

In this video, we are discussing how blood sugar is regulated, how diabetes develops, and how diabetes and prediabetes are diagnosed.- SUBSCRIBE TO THE CHANN...

www.youtube.com

3

5

30

@mario_kratz

Mario Kratz

11 months

New video: "Insulin Resistance: Top Causes and Contributing Factors" Discusses what I consider the 16 major causes of insulin resistance.

Tweet card media

Insulin Resistance: Top Causes & Contributing Factors

In this video, we are discussing the sixteen top causes of insulin resistance.- SUBSCRIBE TO THE CHANNEL FOR MORE CONTENT LIKE THIS -https://www.youtube.com/...

www.youtube.com

4

3

29

@mario_kratz

Mario Kratz

2 years

That then raises the question whether we are losing weight on low-carb diets because we cut out the carbs, or because we cut out all of the ultra-processed junk foods?

2

0

28

@mario_kratz

Mario Kratz

10 months

When we are young, almost all of us have very low blood cholesterol, triglyceride, and glucose levels, and low blood pressure. Once we cross into our 40s, 50s, and particularly 60s, most of us notice that all of these values have gradually crept upward.

Tweet media one

1

3

28

@mario_kratz

Mario Kratz

8 months

To learn more about lipoprotein metabolism and its role in atherosclerotic CVD, watch my YouTube video on the topic:

Tweet card media

Blood Lipids and Cardiovascular Risk: Everything You Need to Know

This video covers the role of blood lipids, specifically LDL-cholesterol, in atherosclerosis and cardiovascular disease.- SUBSCRIBE TO THE CHANNEL FOR MORE C...

www.youtube.com

3

5

28

@mario_kratz

Mario Kratz

8 months

Third, atherosclerosis is a multi-factorial disease that takes decades to develop. It is unreasonable to expect that addressing only one CVD risk factor for a few years will reduce the CVD risk to zero.

2

0

26

@mario_kratz

Mario Kratz

6 months

Help! For my new video and blog post, I am researching factors that increase ad libitum energy intake. I was curious whether diets that elicit greater glycemic and insulinemic responses increase energy intake in the short term (within a meal or two, within a day, or a few

13

4

25

@mario_kratz

Mario Kratz

7 months

New video alert: "A Metabolic Double Whammy: Liquid Calories" Covers the impact of alcoholic and sugar-sweetened beverages on calorie intake, body weight, and liver fat content.

Tweet card media

Keys to a Healthy Body Weight: Avoid Liquid Calories

This video covers evidence linking alcoholic and sugar-sweetened beverages to increased calorie intake, weight gain, and fatty liver disease.- SUBSCRIBE TO T...

www.youtube.com

4

6

26

@mario_kratz

Mario Kratz

2 years

The argument I'd like to make is that the relative changes in carb and fat intake were almost certainly too small to explain the substantial increase in obesity prevalence.

3

0

26

@mario_kratz

Mario Kratz

8 months

In contrast, HDL particles are released by the liver and the GI-tract as a protein, not a full lipoprotein. While VLDL sheds lipids in the blood, HDL particles bind and accumulate lipids while circulating in the blood.

1

1

24

@mario_kratz

Mario Kratz

2 years

A single cause is unlikely because dietary factors don't exist in isolation: UPFs, for example, contain refined carbs as a key ingredient by definition. So, when people started eating more UPFs, they also ate more refined carbs. Vice versa, any low-carb diet is low in UPFs.

3

1

25

@mario_kratz

Mario Kratz

8 months

Of note, the short-term benefits of lowering blood pressure or blood sugar, or of smoking cessation offer a similarly small absolute risk reduction.

2

0

25

@mario_kratz

Mario Kratz

1 year

Just published a new video to answer the 7 most common viewer questions about blood sugar spikes. This video includes a detailed explanation of how I define blood sugar spikes, and why such spikes may be linked to an increased risk of chronic disease.

Tweet card media

Blood Sugar Spikes Q&A

In this video, I answer seven of your most common questions about blood sugar spikes and how to avoid them.- SUBSCRIBE TO THE CHANNEL FOR MORE CONTENT LIKE T...

www.youtube.com

3

6

26

@mario_kratz

Mario Kratz

8 months

VLDL particles are released by the liver. In the blood, VLDL particles shed triglycerides as they pass through tissues. The particle shrinks and becomes denser, it becomes IDL, then LDL. Thus, VLDL, IDL, and LDL are the same particle at different stages in their life cycle.

Tweet media one

1

0

23

@mario_kratz

Mario Kratz

8 months

Second, because a typical lipid-lowering trial has a short duration of only 3-6 years, the CVD incidence is low and usually in the single digits, even in the untreated controls. As a result, the absolute risk reduction cannot even theoretically be an impressively high number.

1

0

24

@mario_kratz

Mario Kratz

8 months

Fasting apo B is considered the best blood lipid measure of CVD risk, followed by non-HDL-cholesterol and LDL-cholesterol. Because Lp(a) is particularly atherogenic, it is often recommended to measure serum Lp(a) once in a lifetime to gauge the overall risk of CVD.

Tweet media one

2

0

25

@mario_kratz

Mario Kratz

2 years

WOW! Great new video by @PlantChompers on the nutrition book landscape in the US. Strongly recommended, because it has an important message, and is fun to watch! Well done, Chris!

1

2

23

@mario_kratz

Mario Kratz

8 months

The lipoproteins differ in their ratio of protein to lipids, with HDL having the most protein and VLDL having the least. Because protein (>1.3 g/mL) is a lot denser than lipids (<1.0 g/mL), the density of a lipoprotein increases with increasing protein content.

Tweet media one

1

0

23

@mario_kratz

Mario Kratz

10 months

New video alert: A Neglected Risk Factor for Chronic Disease: The Insulin Resistance Syndrome Also available as blog post, including all of the references:

Tweet card media

A Neglected Risk Factor for Chronic Disease: The Insulin Resistance Syndrome - Nourished by Science

A common phenomenon people observe as they age is that over time, their blood lipids such as cholesterol and triglycerides, their blood pressure, and their blood sugar levels increase steadily....

nourishedbyscience.com

2

4

23

@mario_kratz

Mario Kratz

2 years

The point of this thread is not to argue against low-carb diets. It is clear that well-planned low-carb diets can be health-promoting, and that many people have benefitted from them tremendously.

1

0

24

@mario_kratz

Mario Kratz

1 year

100% agree with Gil here. There may be a lot of nonsense on YouTube, but creating a world with just a few gatekeepers who control what is and is not credible is very problematic in its own right.

@NutritionMadeS3

Gil Carvalho MD PhD🌈

@NutritionMadeS3

1 year

YouTube's health misinformation policies are extensive. Many ideas around COVID, vaccines, ivermectin, herd immunity and cancer treatment are essentially banned. Reading this list sends a chill down my spine.

10

2

38

6

1

22

@mario_kratz

Mario Kratz

2 years

@robertlufkinmd Both of these views are superficial half-truths. T2DM is primarily an issue of caloric excess (from any macronutrient) that cannot safely be stored in subcutaneous fat tissue.

3

1

22

@mario_kratz

Mario Kratz

2 years

Comparing diets high or low in UPFs with the same carb content, people eat way more calories on the high-UPF diet. Again, inconsistent with the idea that the carb content of the diet is the primary determinant of energy intake and body weight.

1

3

23

@mario_kratz

Mario Kratz

1 year

Yesterday, I posted a poll about whether hyperinsulinemia causes insulin resistance. I recently reviewed the data from hyperinsulinemic-euglycemic clamp studies and patients with insulinoma to understand whether chronically elevated blood insulin triggers insulin resistance.

Tweet media one

2

6

23

@mario_kratz

Mario Kratz

2 years

Have been listening to an 8-part series on the scientific reproducibility crisis on the Healthcare Triage podcast. There is so much in there that resonates deeply. Excellent job by @aaronecarroll and team. Thank you for making this!

@HCTriage

Healthcare Triage

2 years

"The persistent finding is that it's not as credible, the published literature, as we might think it is or as we might hope it would be." Have you listened to episode one of our podcast series on the reproducibility crisis? #academictwitter #science

0

5

11

2

5

23

@mario_kratz

Mario Kratz

8 months

The fact that we can still detect a clinical benefit of lipid-lowering therapy despite the small difference in the cumulative exposure between treated vs. placebo participants speaks volumes as to the importance of apo B particles/LDL-cholesterol in atherosclerosis and CVD risk.

1

0

22

@mario_kratz

Mario Kratz

2 years

If you'd like more detail on my thoughts on these topics, and a list of references, please take a look at the YouTube video below.

Tweet card media

The Global Nutrition Transition (Why Nutrition Matters, Part B)

In this video, we will discuss the dietary changes that may be responsible for the worldwide twin epidemics of obesity and diabetes.- SUBSCRIBE TO THE CHANNE...

www.youtube.com

4

0

22

@mario_kratz

Mario Kratz

1 year

New video and blog post: the measurement of insulin resistance. I am discussing: - why we may want to know whether we are insulin resistant, - who may want to get tested, - which test is recommended, and - how to interpret lab results.

Tweet card media

Measuring Insulin Resistance

A discussion of who may want to measure insulin resistance, why it’s important, which test to get done, and what the lab results mean.- SUBSCRIBE TO THE CHAN...

www.youtube.com

2

7

22

@mario_kratz

Mario Kratz

8 months

Lipoproteins also differ in their lipid composition, with VLDL consisting mostly of triglycerides, while the lipids in LDL and HDL are mostly cholesterol. And lipoproteins differ by size, with VLDL particles having a 6-20 times larger diameter than HDL particles.

Tweet media one

1

1

21

@mario_kratz

Mario Kratz

9 months

@PenelopeFigtree @LowCarbEyeDoc @KenDBerryMD @Drlipid @drjkahn @cardio10s @BioLayne @MohammedAlo @PeterAttiaMD @realDaveFeldman @ethanjweiss Thank you, Penny, very sweet of you. I actually watched the interview between @KenDBerryMD , @realDaveFeldman , and @nicknorwitz , and thought it was a well-balanced discussion, mostly because Nick and Dave, while understandably excited about their data, were both adequately

1

2

21

@mario_kratz

Mario Kratz

8 months

First, any investigator is under the ethical obligation to stop a trial and offer treatment to participants randomized to the placebo group as soon as there is statistical evidence for an a priori-defined clinical benefit. That's why these trials are usually short (3-6 years).

2

0

21

@mario_kratz

Mario Kratz

5 years

Definitely worthy of a first tweet: honored to be part of the team at where we will try to sort out what is and is not based on scientific evidence in popular health and nutrition books.

@sguyenet

Stephan J. Guyenet

5 years

Today, I'm excited to launch a top secret project I've been working on for the last year: Red Pen Reviews. Simply stated, Red Pen Reviews produces the most informative, consistent, and unbiased popular health/nutrition book reviews available.

Tweet media one

46

148

462

4

2

21

@mario_kratz

Mario Kratz

11 months

I recommend this video by @NutritionMadeS3 , in which he interviews @Lipoprotein to discuss the multifactorial nature of atherosclerosis and CVD. With a particular focus on whether insulin resistance and elevated apo B are independent CVD risk factors.

Tweet card media

Can you develop Heart Disease if you're not Insulin Resistant? | Dr....

Can we have plaque in our arteries if we're not insulin resistant? Are "metabolically healthy" people still at risk of heart disease? Does Insulin Resistance...

www.youtube.com

1

1

22

@mario_kratz

Mario Kratz

1 year

@thefoolisingh I recently received a very critical comment on YouTube by a viewer who complained that with the other influencers, you get a clear message, whereas with me there are too many words such as ‘suggest’ or ‘likely’ or ‘inconclusive’ or ‘limitation’ or ‘qualifier’.

6

0

18

@mario_kratz

Mario Kratz

6 months

For a more detailed discussion, including all of the relevant references, please refer to:

Tweet card media

Keys to a Healthy Body Weight: Maximize Satiety per Calorie - Nourished by Science

In this blog post, we will discuss the importance of maximizing satiety per calorie consumed, and the three key factors that make a food or a meal more satiating (or filling).

nourishedbyscience.com

5

0

21

@mario_kratz

Mario Kratz

8 months

Or read the comprehensive blog post, which also includes all of the references related to statements and images included in this thread:

Tweet card media

Blood Lipids and Cardiovascular Risk: Everything You Need to Know - Nourished by Science

In this blog post, we are discussing in detail the basics of atherosclerosis, lipid, and lipoprotein metabolism, the impact of LDL-cholesterol and other blood lipids on atherosclerotic cardiovascular...

nourishedbyscience.com

5

3

21

@mario_kratz

Mario Kratz

8 months

These lipoprotein classes are not totally distinct particles; instead, they span the entire range in terms of composition, density, and size. That is because lipoproteins constantly change in the blood by shedding or accepting lipids and proteins.

Tweet media one

1

1

20

@mario_kratz

Mario Kratz

1 year

New video: a conversation with @PenelopeFigtree , an Australian MD, whose use of a CGM revealed that her blood sugar spikes in response to some supposedly 'healthy' foods, and that these spikes are frequently followed by reactive hypoglycemia.

5

5

19

@mario_kratz

Mario Kratz

8 months

All apo B-carrying lipoproteins are considered atherogenic. These include VLDL, IDL, LDL, and Lp(a). Because each of these has exactly one copy of apo B, we can assess the number of all atherogenic lipoproteins by measuring the concentration of apo B in fasting blood.

2

1

18

@mario_kratz

Mario Kratz

9 months

An idea for a new LMHR project: Characterize the 24-h-DIURNAL variations in apo B/LDL-chol in LMHRs consuming a ketogenic diet vs. controls not in ketosis consuming normal mixed macronutrient meals. Hypothesis: the reduction in apo B/LDL-chol in the postprandial period is more

6

3

20

@mario_kratz

Mario Kratz

2 years

Really appreciate this video here by @NutritionMadeS3 , particularly for explaining very well how to think about the scientific process and the concept of uncertainty in science. Well done, Gil!

Tweet card media

We're all confused about Red Meat. Here's Why.

Why is red meat so controversial? Heart disease or heart-healthy? Grass-fed or grain-fed? Established or undetermined? Beef, lamb, bacon or ham?A look at the...

www.youtube.com

4

3

20

@mario_kratz

Mario Kratz

8 months

For example, the difference in the cumulative lifetime exposure to LDL-cholesterol between someone who has been treated with a lipid-lowering medication starting at age 60 (green) vs. placebo (red) is initially small (green-shaded area +/- yellow-shaded area).

Tweet media one

2

0

20

@mario_kratz

Mario Kratz

2 years

New video and blog post: The Dietary Glycemic Index: Everything You Need to Know. Covers the glycemic index and glycemic load of common foods and explains how they are calculated.

Tweet card media

The Dietary Glycemic Index: Everything You Need to Know

The glycemic index and the glycemic load: what they are, how they are calculated, and how they can be used to lower blood sugar levels.- SUBSCRIBE TO THE CHA...

www.youtube.com

1

7

19

@mario_kratz

Mario Kratz

2 years

When following the public discourse about nutrition and health, one can get the impression that few foods are safe for human consumption. Allegedly, carbs give us obesity and T2DM, fats lead to heart disease, and protein to cancer. 1/4

1

0

15