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Hans-Joachim Anders Profile
Hans-Joachim Anders

@hjanders_hans

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Physician scientist at LMU Munich searching ways to maximize kidneys` lifespan, EiC of NDT

Follow me on researchgate.net
Joined March 2015
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@hjanders_hans
Hans-Joachim Anders
2 years
Fresh from the press in @NatRevImmunol The 5 types of glomerulonephritis that connect pathogenesis with immunotherapy thanks to @PRomagnani @KitchingLab and Nelson Leung from Mayo
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@hjanders_hans
Hans-Joachim Anders
3 months
Now online in @NDTsocial Hyponatremia - Treatment standard 2024 🥸 A gradual correction and clinical evaluation is preferable over the rapid normalization of serum sodium towards the laboratory reference ranges. ▶️
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@hjanders_hans
Hans-Joachim Anders
4 years
Cardiorenal Syndrome Type 3 @NEJM
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@hjanders_hans
Hans-Joachim Anders
24 days
Our latest review just went online in @NatRevRheumatol #Lupus nephritis-related chronic CKD Check out all things to do beyond prescribing immunosuppressants to improve kidney outcomes (together with your nephrologist) Here is a free view only link
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@hjanders_hans
Hans-Joachim Anders
3 months
Now open access in @NDTsocial Antibody-mediated podocytopathies: a disease entity that implies immunotherapy 🧐A novel disease concept beyond MCD/FSGS lesion patterns discussed by the Immunonephrology Working Group of @ERAkidney ▶️
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@hjanders_hans
Hans-Joachim Anders
4 years
All you need to know about ANCA vasculitis. Epidemiology-Clinical Presentation- Pathophysiology, Diagnosis, Biomarkers, Management, QoL, Outlook, @eular_org @ERAEDTA @ISNkidneycare @GlomCon @RELENT_EU @DiseasePrimers
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@hjanders_hans
Hans-Joachim Anders
11 months
Now free online in @NDTsocial "ANCA vasculitis Treatment Standard" by @davidjayne2 et al. ▶️ GPA/MPA ▶️ EGPA
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@hjanders_hans
Hans-Joachim Anders
8 months
Now open access in @NDTsocial Management of adult patients with podocytopathies - an update from the ERA Immunonephrology Working Group @smirioglu @AKronbichler ▶️
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@hjanders_hans
Hans-Joachim Anders
4 years
Our primer on "Lupus nephritis" is now free online during the Springer Nature collection “Rheumatic Disease Awareness Month” until Oct 20. @kidneydoc101 @BradRovin
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@hjanders_hans
Hans-Joachim Anders
1 year
The new IF of the #kidney journals
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@hjanders_hans
Hans-Joachim Anders
1 year
Lupus nephritis treatment algorithm according to EULAR 2023
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@hjanders_hans
Hans-Joachim Anders
2 years
New impact factors of kidney journals found on Clarivate Journal Citation Reports 🤓😀👏🎉
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@hjanders_hans
Hans-Joachim Anders
1 year
🥳Long journey from writing (small parts) to holding the heavy book in the hands. A lot of knowledge and beautiful images...enjoy thanks @AgnesFogo
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@hjanders_hans
Hans-Joachim Anders
2 months
Now online at @NDTsocial @HerrmannMd Immune checkpoint inhibitor-associated nephritis - treatment standard 🧐A subset of patients will require additional steroid-sparing therapies for corticosteroid-dependent or refractory ICI-AKI. ▶️
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@hjanders_hans
Hans-Joachim Anders
1 year
Chronic kidney disease is coming to the stage. Check this special edition of Nature (Nature)
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@hjanders_hans
Hans-Joachim Anders
1 year
IgAN, MN, SLE, ANCA-GN,... all seem different GNs but all develop from same immune system. Only AGs differ ⏩location of 🔥. But we don`t target AG! We target always the same immune system. Tx differs only by level of autoimmune activity ⏩ basket RCTs
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@hjanders_hans
Hans-Joachim Anders
3 years
How the ratio of kidney workload per no. of nephrons determines healthy kidney ageing versus progressive CKD. @valerie_luyckx @PRomagnani @KatherineTuttl8 @PStoneOftheYear @NatRevNeph
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@hjanders_hans
Hans-Joachim Anders
4 years
Now open access in Nat Rev Dis Primers "Podocytopathies" An updated view on nephrotic syndromes (MCD, FSGS, SSNS, SRNS, ...). Role of APOL1, global epidemiology, pathomechanisms, diagnostics, QoL, and management. @nephcure
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@hjanders_hans
Hans-Joachim Anders
1 year
During his 25 years as a nephrologist, HJA has travelled to many conferences on kidney disease. On his return, his patients often ask him if he has learnt anything relevant to them. For more than two decades, “I had to tell them no”… 🙏 that changed
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@hjanders_hans
Hans-Joachim Anders
6 months
Now open access in @NDTsocial Editorial by ERA president-elect @torra_roser 👉Kidney disease - the elefant in the room ▶️
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@hjanders_hans
Hans-Joachim Anders
1 year
Finally out:
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@hjanders_hans
Hans-Joachim Anders
10 months
Now open access in @NDTsocial The new generation of B cell-targeting therapies for the treatment of autoimmune kidney diseases ▶️
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@hjanders_hans
Hans-Joachim Anders
24 days
1. episode of #lupus nephritis = irreversible nephron loss, which 🔽kidney functional reserve, e.g., needed for a pregnancy. Result: HTN, proteinuria, preeclampsia rates as kidneys do not stand the ⬆️workload. Same with obesity/DM later in life
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@hjanders_hans
Hans-Joachim Anders
20 days
Now open access in the October issue of @NDTsocial @AndrewRuleMD Structural adaptation to hyperfiltration defines CKD versus healthy aging ▶️
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@hjanders_hans
Hans-Joachim Anders
1 year
⏩ Check this: Target RR, SGLT2inh, finerenone, chlorthalidone, etc 2023 ESH Guidelines for the management of arterial... : Journal of Hypertension
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@hjanders_hans
Hans-Joachim Anders
11 months
Now released by @NDTsocial Anaemia in CKD - treatment standard by Ian MacDougall ⏩
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@hjanders_hans
Hans-Joachim Anders
1 year
@NDTsocial Latest GN supplement all free online ▶️New GN classification ▶️Factor Bb predicts IgAN outcomes ▶️All immunomodulatory drugs for kidney disease ▶️Novel complement inhibitors for GN ▶️How to prevent infections in GN ▶️CKD therapy in GN
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@hjanders_hans
Hans-Joachim Anders
4 months
Now open access in @NDTsocial A Stain Reclaimed: The Legacy of Drs. Prescott & Brodie by @jrseltzer @VelezNephHepato @rmothy 🧐This stain reduces confusion for both the novice and experienced clinician doing urinary microscopy. ⏩
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@hjanders_hans
Hans-Joachim Anders
1 year
The adverse effect of SGLT2 inh not reported in RCTs/metanalysis: Worrisome increases in Hgb levels - now free online in NDT Sodium-glucose co-transporter-2 inhibitor use and erythrocytosis: assessment of risk and need for referral to hematology
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@hjanders_hans
Hans-Joachim Anders
25 days
Now open access in @NDTsocial SELECT: a 10% reduction in body weight with GLP-1 receptor agonists improves kidney outcomes in overweight and obese patients without diabetes
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@hjanders_hans
Hans-Joachim Anders
1 year
Now free online from NATURE
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@hjanders_hans
Hans-Joachim Anders
1 year
The NDT editorial on the NEJM CONVINCE study comparing outcomes of HD versus HDF dialysis. Haemodiafiltration for all: are we CONVINCEd?
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@hjanders_hans
Hans-Joachim Anders
8 months
Now open access in @NDTsocial CKD screening for better kidney health: Why? Who? How? When? by @KatherineTuttl8 ▶️
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@hjanders_hans
Hans-Joachim Anders
1 year
Now open access in @NDTsocial Kidney disease diagnosed with urine analysis only
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@hjanders_hans
Hans-Joachim Anders
8 months
Now online in @NDTsocial #SGLT2 inhibition in primary/secondary forms of glomerulonephritis ▶️
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@hjanders_hans
Hans-Joachim Anders
1 year
If something in nephrology is too complicated to be explained to medical students, e.g., #glomerulonephritis , it`s likely not yet well understood Read how everyone can understand the GNs: ▶️ @KitchingLab @PRomagnani
@PhysInHistory
Physics In History
1 year
The most important equations in Physics and Mathematics 🧠
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@hjanders_hans
Hans-Joachim Anders
5 years
60% diagnostic rate with genetic testing in steroid-resistant nephrotic syndrome. Phenocopies as frequent as podocytopathies #SRNS @CJASN @KidneyNews @IPNA_PedNeph @Nephcure
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@hjanders_hans
Hans-Joachim Anders
20 days
Now open access in @NDTsocial IV methylprednisolone for nephrotic syndrome with minimal change lesions in adults: a RCT 🧐 Short-term IV MP followed by oral pred may be a better choice for NS patients with MC lesions ▶️
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@hjanders_hans
Hans-Joachim Anders
4 months
Now online in @NDTsocial Clinical and histological comparison of IgAN and renal IgAV 🧐 IgAN and IgAV follow distinct courses/require different tx strategies. Oxford classif.&LN-CI can categorize and predicting long-term prognosis in both ▶️
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@hjanders_hans
Hans-Joachim Anders
9 months
Now out in @NDTsocial When to use either spironolactone, eplerenone or finerenone in the spectrum of cardiorenal diseases ▶️
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@hjanders_hans
Hans-Joachim Anders
1 year
Association between serum iron markers, iron supplementation, and cardiovascular morbidity in pre-dialysis chronic kidney disease | Nephrology Dialysis Transplantation | Oxford Academic
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@hjanders_hans
Hans-Joachim Anders
4 years
New impact factors of #Kidney journals
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@hjanders_hans
Hans-Joachim Anders
1 year
Do you know our short author videos of accepted @NDTsocial papers? Here is our latest on SGLT2i in GN Here is the full collection of NDT author videos (free access)
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@hjanders_hans
Hans-Joachim Anders
4 years
Kidney update 2020 from @ScienceMagazine with contributions of @KSusztak @PRomagnani @mrins01
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@hjanders_hans
Hans-Joachim Anders
8 months
Now online in @NDTsocial A predictive mortality score in ANCA-associated renal vasculitis ▶️
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@hjanders_hans
Hans-Joachim Anders
7 months
Now open access in J Autoimmun Balancing efficacy and safety of complement inhibitors
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@hjanders_hans
Hans-Joachim Anders
2 months
Now online in @NDTsocial Anti-C1Q monitoring predicts relapses of #lupus nephritis 🧐High titres of anti-C1qAb at start of therapy and their persistent positivity at 1 year is strongly associated with renal flares. ▶️
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@hjanders_hans
Hans-Joachim Anders
1 year
Recovery of Kidney Function After Acute Kidney Disease - a Multi-Cohort Analysis
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@hjanders_hans
Hans-Joachim Anders
1 year
Important concepts because low nephron no is a 🔝RF for HTN, proteinuria of any cause, pre-eclampsia, DKD, progression of CKD, AKI/CKD transition etc etc. Nephrons develop by log2 , so most come from the last rounds of branching = last wks of pregnancy @valerie_luyckx
@NatRevNeph
Nature Reviews Nephrology
1 year
Nephrogenesis in the mouse
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@hjanders_hans
Hans-Joachim Anders
4 years
Does this compromize the ongoing IgAN trials that do not include SGLT2 inhibition as SOC? Will there really be still a need for immune modulators for IgAN, if dual RAS/SGLT2 inhibition is so potent? #asn2020
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@hjanders_hans
Hans-Joachim Anders
5 months
Now free online in @NDTsocial Genetic kidney stones disease in adults Editorial by Bernd Hoppe, et al 🧐New treatment options in rare metabolic diseases are now available ▶️
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@hjanders_hans
Hans-Joachim Anders
2 months
Now open access in @NDTsocial Extrarenal manifestations in inherited kidney diseases 🧐The interplay between genetic variants and molecular pathways underscores the importance of exploring the extrarenal aspects of inherited kidney diseases. ▶️
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@hjanders_hans
Hans-Joachim Anders
2 years
HTN and CKD are frequently associated and causality HTN->CKD is a popular misconcept. The fact that monogenic forms of HTN do not cause CKD disproves HTN->CKD theory. CKD->HTN ! "Essential" HTN: 1. Urine exam, nephron no?, birth weight?, previous AKI?, etc... 2. Aldo/Renin
@GlassockJ
Richard J. Glassock
2 years
@valerie_luyckx Hypertension as a cause of CKD? Think again, please.
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@hjanders_hans
Hans-Joachim Anders
2 months
Now open access in @NDTsocial Placement of tunneled hemodialysis catheters - interventional standard 🧐Novel developments include catheter placement with ultrasound-guidance or ECG-guidance. ▶️
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@hjanders_hans
Hans-Joachim Anders
6 months
Now open access in @NDTsocial Albuminuria predicts #kidney events in IgAN 📢 Lower levels of UACR significantly associated with MAKE (major adverse kidney events) 👉 IgAN is glomerular and a form of CKD. UACR seems to be top for assessment ⏩
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@hjanders_hans
Hans-Joachim Anders
4 years
Congrats to @StefanieSteige6 for her mechanistic explanation on the controversy on the role of uric acid in the progression of #CKD . Maybe crystalluria can help to identify pts. that potentially benefit from urate-lowering therapy? No role w/o crystals!
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@hjanders_hans
Hans-Joachim Anders
1 year
Everyone speaks about AKI, few speak about AKD, but many pts develop AKD w/o AKI. AKD +/- AKI has important consequences on mortality and subsequent CKD. Incidence and prognosis of AKI versus AKD among 71,041 inpatients
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@hjanders_hans
Hans-Joachim Anders
1 month
Now online in @NDTsocial Metabolic Alkalosis Treatment Standard 🧐While metabolic alkalosis is frequently not dangerous, in certain settings, metabolic alkalosis may contribute to mortality and should be aggressively managed ▶️
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@hjanders_hans
Hans-Joachim Anders
11 months
Had a rhabdomyolysis case today with eGFR(Cr): 15 ml/min and eGFR(Cys): 60 ml/min !?? Good read and now open access in @NDTsocial ▶️"Diagnostic standard: Assessing GFR" by @PStoneOftheYear , et al.
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@hjanders_hans
Hans-Joachim Anders
8 months
Now open access in @NDTsocial Effectiveness and safety of direct oral anticoagulants versus vitamin K antagonists in patients on chronic dialysis ⏩
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@hjanders_hans
Hans-Joachim Anders
7 months
Now online in @NDTsocial Eculizumab for pregnancy-related aHUS 😇 Kidney survival data much improved with C5 blockade ▶️
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@hjanders_hans
Hans-Joachim Anders
3 years
New data on #Belimumab in #lupusnephritis online in @Kidney_Int by @BradRovin BEL attenuates eGFR decline and the risk for LN flares, the main treatment goals in LN!! Lets get away from #proteinuria in kidney RCTs!!
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@hjanders_hans
Hans-Joachim Anders
2 years
Proud to be named a Highly Cited Researcher 2022 by @ClarivateAG . See the full list #HighlyCited2022 Thanks to everyone reading and citing our research!!
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@hjanders_hans
Hans-Joachim Anders
4 months
Now open access in @NDTsocial Magnesium Biology 🧐Recently, prebiotic dietary fibers and SGLT2 inhibitors have been proposed as promising new therapeutic pathways to treat hypomagnesemia. ▶️
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@hjanders_hans
Hans-Joachim Anders
5 months
Now OA in @NDTsocial Primary immunodeficiency (PID) as a cause of immune-mediated kidney diseases 👉PIDs can cause autoimmunity 👉largely neglected in nephrology 👉many possibilities for research 👉PID as cause for infectious complications ▶️
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@hjanders_hans
Hans-Joachim Anders
1 year
Now open access in @NDTsocial The plethora of immunomodulatory drugs: opportunities for immune-mediated kidney diseases @AKronbichler @odlerb
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@hjanders_hans
Hans-Joachim Anders
5 years
Every patient with #lupusnephritis is a CKD pt. With every LN episode she/he looses nephrons (just as in an AKI episode), Nephron loss = shortening of #kidney life span! Thus, let a pt. with LN NEVER have a 2. LN episode, AKI, drug tox, etc. Check out at
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@hjanders_hans
Hans-Joachim Anders
5 months
Now online in @NDTsocial Prophylactic treatment of FSGS recurrence in pts who relapsed in a previous kidney graft 🧐Better no prophylactic treatment in pts receiving a 2nd graft after recurrent FSGS in a previous graft ⏩
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@hjanders_hans
Hans-Joachim Anders
7 months
Now open access in @NDTsocial Cardio-renoprotective effects of SGLT2 inhibitors—the role of anaemia correction 😇 more erythropoiesis and hemoconcentration ⏩
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@hjanders_hans
Hans-Joachim Anders
8 months
Now open access in @NDTsocial Membranous Nephropathy Treatment Standard ▶️
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@hjanders_hans
Hans-Joachim Anders
2 years
1. Most drugs for GN act outside the kidney (spleen, lymph nodes, bone marrow) 2. Long pipeline of drugs for 3 of the 5 groups of GN that connect immunopathogenesis + immunotherapy Now in @NatRevImmunol @KitchingLab @PRomagnani , Nelson Leung Free online:
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@hjanders_hans
Hans-Joachim Anders
1 year
Pregnancy-related hyperfiltration is a kidney stress test and those with insufficient reserve to adapt to the increased workload develop HTN and proteinuria like everyone else that exceeds reserve (DM, obesity, low nephron no).
@kidneydoc101
Prof Liz Lightstone PhD FRCP FISN 🇬🇧🇮🇱🇺🇦🇵🇸
1 year
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@hjanders_hans
Hans-Joachim Anders
4 months
Now online in @NDTsocial A novel approach to induce early remission in high-risk primary membranous nephropathy 👉A combination of RTX, IVCYC, and steroids is effective and safe in high-risk pts ▶️
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@hjanders_hans
Hans-Joachim Anders
3 months
Now online in @NDTsocial Biology of the proximal tubule in body homeostasis and kidney disease 🧐The PT is critical for understanding disease phenotypes, their systemic complications and for developing new therapeutic strategies ▶️
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@hjanders_hans
Hans-Joachim Anders
6 years
Podocyte-progenitor feedback mechanism inhibiting intrinsic capacity of podocyte regeneration identified! Novel target to stimulate podocyte regeneration and reduce proteinuria in glomerular disease @Kidney_int @ISNkidneycare @PRomagnani
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@hjanders_hans
Hans-Joachim Anders
5 years
Fresh from the press: "Lupus nephritis" in Nature Reviews Disease Primers @kidneydoc101 @LupusOrg @LupusInitiative
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@hjanders_hans
Hans-Joachim Anders
3 years
End of #2021 token. Just received a copy of this book to which we had the honour to contribute a chapter on renal hemodynamics and the RAS together with @PepaSolerR @MotrapuManga . Thanks @edgarvlermamd and crew. Note that the book title avoids DN/DKD!!
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@hjanders_hans
Hans-Joachim Anders
8 months
Now open access in @NDTsocial 😬Weight loss with GLP1- and dual-receptor agonists affect both SCr and Cys-based eGFR formulas suggesting fake kidney function improvements 📢One possible solution: remove body surface correction ⏩
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@hjanders_hans
Hans-Joachim Anders
3 years
Important milestone in nephrology. Finally, we can treat hemodynamic and metabolic overload of the remaining nephrons, the major drivers of CKD progression 👍
@ValleAlfonso
Alfonso Valle
3 years
📰 #Dapagliflozin approved in the 🇪🇺 @EMA_News for the treatment of chronic kidney disease in patients with and without type-2 diabetes 👉 Approval based on unprecedented #DAPA -CKD @secardiologia @SENefrologia @CardioRenalSEC 📌
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@hjanders_hans
Hans-Joachim Anders
3 months
Now online in @NDTsocial Chimeric HLA antibody receptor T cell therapy for humoral transplant rejection 🧐 From CAR-T cells to CHAR-T cells in order to target alloreactive ab-producing immune cells in the recipient ▶️
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@hjanders_hans
Hans-Joachim Anders
3 years
Now out in @NatRevNeph : Nephron overload as a therapeutic target to maximize kidney lifespan. Why #SGLT2 inhibitors work in CKD, and...and...and. @valerie_luyckx @PRomagnani @PStoneOftheYear @KatherineTuttl8
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@hjanders_hans
Hans-Joachim Anders
1 year
Novartis investigational iptacopan Phase III study demonstrates clinically meaningful and highly statistically significant proteinuria reduction in patients with IgA nephropathy (IgAN) | Novartis
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@hjanders_hans
Hans-Joachim Anders
2 years
Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-I) - The Lancet. Also check this:
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@hjanders_hans
Hans-Joachim Anders
1 year
Now free online in @FrontImmunol Macrophages and fibrosis: how resident and infiltrating mononuclear phagocytes account for organ injury, regeneration or atrophy @buschraml @PRomagnani
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@hjanders_hans
Hans-Joachim Anders
1 year
One of the first new NDT treatment Standards, the new clinical guidance format of @NDTsocial from @ERAkidney
@_JamesGleeson
James Gleeson
1 year
Delighted to share our state-of-the-art review on treatment of IgAN in @NDTsocial . Honoured to work on this with @IgAN_JBarratt and @MichelleOShaug3 . Exciting times for IgAN therapeutics!
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Hans-Joachim Anders
5 years
Good to remind (and teach...). Interferences in the different methods to measure SCr.
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@hjanders_hans
Hans-Joachim Anders
5 years
These results have important implications! Once SCr is elevated (CKD3 or more) it's tooo late (>65% of nephrons lost). Treating CKD must start from the stage of urinary abnormalities (or before). Thus, the window-of-opportunity is mostly in the hands of GPs, not nephrologists.
@GlomCon
GlomCon
5 years
Use of ACE inhibitors delays progression of kidney disease in patients with Alport syndrome By Dr Rheault @rheault_m #glomcon
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@hjanders_hans
Hans-Joachim Anders
3 months
Now online in @NDTsocial The effect of preeclampsia on long-term kidney function among pregnant women with CKD 🧐Preeclampsia = greater risk of long-term CKD progression or ESKD , especially in patients with early-onset preeclampsia. ▶️
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@hjanders_hans
Hans-Joachim Anders
8 months
Now open access in @NDTsocial IgA nephropathy: gut microbiome regulates the production of hypoglycosilated IgA1via the TLR4 signaling pathway ▶️
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@hjanders_hans
Hans-Joachim Anders
4 years
How hyperuricemia with or without UA crystalluria affects the kidney. Mechanisms explaining #PERL #CKDFIX For next CKD allopurinol trial include only pts with UA crystalluria! @StefanieSteige6 @JASN_News Now online in JASN
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