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CJASN

@CJASN

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The leading voice for the latest advancements in clinical nephrology. Official publication of @ASNKidney . Impact Factor 9.8.

Washington, DC
Joined August 2014
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@CJASN
CJASN
2 years
SGLT2 inhibitors are now embedded in clinical practice guidelines to slow the progression of CKD in patients with and without diabetes mellitus. This Review discusses the kidney-protective effects of SGLT2 inhibitors
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@CJASN
CJASN
10 months
Combination diuretic therapy is a widely applied strategy to counter renal sodium avidity. This Review discusses the results of the key studies on combination diuretic therapy in the setting of acute heart failure and their findings @AmirKazory
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@CJASN
CJASN
9 months
The benefits of SGLT2 inhibitors in patients with CKD have been well established in major clinical trials. This Perspective examines if SGLT2 inhibitors are effective & safe in patients with severe CKD, dialysis, or kidney transplantation @StefanPBerger
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@CJASN
CJASN
2 years
AKI is a syndrome that is often multifactorial, especially in the hospitalized patient. This Review discusses the pathophysiology of three etiologies that cause AKI: kidney hypoperfusion, abdominal compartment syndrome, & urinary tract obstruction
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@CJASN
CJASN
2 years
SGLT2 inhibitors are a critical part of clinical practice guidelines for the management of patients with cardiovascular disease with and without diabetes. This Review discusses the mechanisms by which they act and the potential changes in kidney function
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@CJASN
CJASN
2 years
SGLT2 inhibitors have become an integral part of clinical practice guidelines to slow CKD progression. This Review examines the mechanisms by which this class of compounds provide kidney protection and how they impact various aspects of kidney homeostasis
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@CJASN
CJASN
1 year
The cardiorenal syndrome refers to a group of complex, bidirectional pathophysiological pathways involving dysfunction in both the heart and kidney. This Review focuses on the cardiorenal syndrome encountered in the hospital setting
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@CJASN
CJASN
3 years
The KDIGO 2021 Clinical Practice Guideline for the Management of BP in CKD includes new recommendations on BP management for individuals with non-dialysis CKD. This Kidney Case Conference: How I Treat article presents a case that incorporates these updates
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@CJASN
CJASN
2 years
Pseudohyperaldosteronism is a syndrome featuring hypokalemia, metabolic alkalosis and suppressed renin in the absence of elevated aldosterone levels. This Kidney Case Conference: How I Treat article presents a schema for diagnosis and management
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@CJASN
CJASN
1 year
Fluid overload is the primary reason for admission of patients with acute heart failure. In this Review, Dr @AmirKazory provides an overview of the results of the key studies on combination diuretic therapy in the setting of acute heart failure
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@CJASN
CJASN
1 year
The clinical benefits of SGLT2 inhibitors in patients with CKD have been well established. This Perspective explores if SGLT2 inhibitors will also be effective in patients with severe CKD, Dialysis, or Kidney Transplantation @StefanPBerger
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@CJASN
CJASN
8 months
Rhabdomyolysis is a condition characterized by the destruction of skeletal muscle fibers and the release of intracellular contents into the bloodstream. This article discusses the management of rhabdomyolysis-induced AKI @javo_neyra
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@CJASN
CJASN
11 months
CJASN is pleased to announce that @ConnieMRhee , MD, MSc, has been appointed Editor-in-Chief. She will begin her term on January 1, 2024. Dr. Rhee is currently a member of the CJASN Editorial Board and is the first female CJASN Editor-in-Chief. Learn more:
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@CJASN
CJASN
4 months
Nephrologists are frequently consulted when the cause of high anion gap metabolic acidosis is not readily apparent. This article discusses the use of a modified version of the CUTE DIMPLES mnemonic in the evaluation of high anion gap metabolic acidosis
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@CJASN
CJASN
2 months
Blood purification by dialysis is a nephrology cornerstone. This Perspective provides an update on current knowledge on hemoadsorption and describes its current use and research agenda for the future @ForniLuiG
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@CJASN
CJASN
3 years
This study found that most patients with kidney failure undergoing hemodialysis developed a substantial antibody response after vaccination with Pfizer-BioNTech COVID-19 vaccine, but it was significantly less than that of individuals without kidney disease
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@CJASN
CJASN
5 years
Did you miss the @CJASN special series "Glomerular Disease: Update for the Clinician "? We have you covered. Download the compiled PDF of the series here:
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@CJASN
CJASN
1 year
Cardiorenal syndrome refers to a complex group of disorders involving dysfunction in the heart & kidneys. This article reviews the cardiorenal syndrome in the hospital setting, defined by declines in kidney function in acute decompensated heart failure
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@CJASN
CJASN
8 months
Nephrologists are often consulted when the cause of high anion gap metabolic acidosis is not apparent. This Kidney Case Conference: How I Treat article uses a modified version of the CUTE DIMPLES mnemonic to evaluate high anion gap metabolic acidosis
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@CJASN
CJASN
2 years
Cardiorenal syndrome is a group of bi-directional pathways involving declining heart & kidney function. This article reviews cardiorenal syndrome encountered in the hospital setting defined by declines in kidney function & acute decompensated heart failure
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@CJASN
CJASN
6 months
"IgA nephropathy may not be that slow progressive disease we once believed it was." This Editorial discusses the long-term effects of IgA nephropathy @kdjhaveri @Joyita_4 @HofstraKidney
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@CJASN
CJASN
6 years
Special Series- Glomerular Diseases: Update for the Clinician now available online as a downloadable single pdf file on the CJASN homepage #openaccess @rajmehrotra1122
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@CJASN
CJASN
10 months
Tumor lysis syndrome results from the destruction of malignant cells, releasing intracellular content into the extracellular space. This Kidney Case Conference: How I Treat article discusses optimal treatment for tumor lysis syndrome
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@CJASN
CJASN
4 months
Rhabdomyolysis is a condition characterized by the destruction of skeletal muscle fibers and the release of intracellular contents into the bloodstream. This Kidney Case Conference: How I Treat article discusses treatment of rhabdomyolysis-induced AKI
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@CJASN
CJASN
5 years
Did you miss the @CJASN special series "Renal Physiology for the Clinician"? No problem, it's now available in a compiled PDF that you can download here:
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@CJASN
CJASN
6 months
Intensive BP lowering in SPRINT produced decreases in kidney function & higher AKI risk. This study found intensive BP lowering was linked to a steeper slope of decline in eGFR and higher risk for kidney events during the intervention phase of the trial
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@CJASN
CJASN
2 years
ANCA-associated vasculitides are multisystem disorders that affect the kidneys with an aggressive inflammation. In this Kidney Case Conference: How I Treat article, Drs @BrixSilke & @VladimirTesar discuss the use of rituximab in severe ANCA-associated GN
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@CJASN
CJASN
10 months
KDIGO guidelines recommend anti-PLA2R antibody levels as a marker of treatment response in membranous nephropathy. This Podcast discusses findings that anti-PLA2R antibody levels with albumin levels after 3 months of treatment was the optimal method
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@CJASN
CJASN
3 months
Sotagliflozin is a dual SGLT1 and 2 inhibitor that has demonstrated CV benefits. This study found sotagliflozin reduced the risk of kidney and cardiorenal composite end points in patients with type 2 diabetes and CKD @AOdutayo
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@CJASN
CJASN
4 months
SGLT2 inhibitors are a critical component of clinical practice guidelines for cardiovascular disease management. This Review discusses changes in kidney physiology after the SGLT2 inhibitor administration predicted to cause both hypokalemia & hyperkalemia
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@CJASN
CJASN
4 years
A review highlights knowledge gaps in the use of intravenous albumin for mitigating hypotension & augmenting ultrafiltration. It discusses the implications of hypoalbuminemia & the potential risks & benefits of intravenous albumin use for these indications
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@CJASN
CJASN
3 years
Euglycemic Ketoacidosis as a Complication of SGLT2 Inhibitor Therapy. Review looks at risk factors & treatments of SGLT2i-induced ketoacidosis in individuals with kidney disease. Precautions are discussed that can decrease likelihood of this complication
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@CJASN
CJASN
2 months
Nonlupus full house nephropathy is a rare, complex entity. This study supports that SLE and nonlupus full house nephropathy are distinct clinical entities, with comparable outcomes @AKronbichler
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@CJASN
CJASN
2 years
AKI is commonly encountered in patients with decompensated cirrhosis, and the burden of kidney dysfunction in this population is rising. This article discusses management of AKI in patients with liver disease @VelezNephHepato
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@CJASN
CJASN
11 months
The role of albumin in kidney injury remains controversial. Is it a marker of advancing glomerular injury, a marker of proximal tubule injury and dysfunction, or a combination of both? This Perspective examines studies on the kidney toxicity of albumin
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@CJASN
CJASN
1 year
The role of albumin in kidney injury remains controversial. Is it a marker of advancing glomerular injury, a marker of proximal tubule injury and disfunction or a combination of both? This Perspective examines recent studies on toxicity of albumin
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@CJASN
CJASN
1 year
The application of continuous KRT varies due to a lack of standardization in how the treatments are prescribed, delivered, and optimized. This article presents an overview of the therapy, recent clinical trials, and outcome studies @UTSWNephrology
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@CJASN
CJASN
1 year
KDIGO guidelines recommend following anti-PLA2R antibody levels as a marker of treatment response in membranous nephropathy. This study found the optimal method to evaluate risk factors for was to use anti-PLA2R antibody & albumin levels after 3 months
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@CJASN
CJASN
2 years
Infections are a common complication of transplantation. This Review summarizes the current epidemiology of postkidney transplant infections, focusing on key viral, bacterial, and fungal infections, as well as guidelines for safe living post-transplant
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@CJASN
CJASN
2 months
Lowering dialysate sodium concentration may improve volume & BP control in patients on maintenance hemodialysis. This study found use of a dialysate sodium concentration of 135 was linked to a small reduction in interdialytic weight gain @DanTheKidneyMan
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@CJASN
CJASN
3 months
Nephrologists are frequently consulted when the cause of high anion gap metabolic acidosis is not readily apparent. This article presents a modified version of the CUTE DIMPLES mnemonic and its use in the evaluation of high anion gap metabolic acidosis
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@CJASN
CJASN
10 months
Hematuria is frequently present in podocytopathies. This study found hematuria is prevalent among participants with the three podocytopathies and is significantly and independently associated with worse kidney-related outcomes
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@CJASN
CJASN
10 months
Over the past several decades, the percentage of time that nephrologists spend caring for patients in ICUs has increased. Our Critical Care Nephrology and AKI Series covers broad aspects of critical care nephrology Read the completed collection: #jnlcoll
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@CJASN
CJASN
2 years
Guidelines for systemic lupus erythematosus (SLE) recommend kidney biopsy at a urine protein-creatinine ratio of ≥0.5 g/g. In this study of patients with SLE & low-grade proteinuria, over half progressed to a urinary protein-creatinine ratio of ≥0.5 g/g
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@CJASN
CJASN
2 years
Critically ill patients with cancer are at highest risk of developing AKI. This Review highlights the epidemiology of AKI in critically ill patients with cancer, risk factors for AKI, and common pathologies associated with certain cancer therapies
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@CJASN
CJASN
2 years
While the definition of sepsis has evolved significantly in the past 30 years, early recognition & intervention remain hallmarks for sepsis management. This Critical Care Nephrology & Acute Kidney Injury article focuses on modern sepsis management methods
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@CJASN
CJASN
5 years
Catch up on the @CJASN special series "Renal Immunology for the Clinician," now available for download in a compiled PDF here:
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@CJASN
CJASN
2 years
Sepsis accounts for high morbidity, mortality, & economic burden. Early recognition & intervention are hallmarks for sepsis management. This Review discusses modern sepsis management methods & examines optimum initial resuscitation of patients with sepsis
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@CJASN
CJASN
2 years
Diabetic kidney disease (DKD) is the most frequent cause of kidney failure, accounting for half of all cases worldwide. This article presents unmet needs for practice, policy, and research in DKD and strategies for improvement @ChristosArgyrop @DrLesWong
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@CJASN
CJASN
7 months
Hematuria is frequently present in podocytopathies. This study shows hematuria is significantly and independently associated with worse kidney-related outcomes, including both progressive loss of kidney function and remission of proteinuria.
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@CJASN
CJASN
3 years
Nephropharmacology for the Clinician: This series is a vital resource for the basic principles and considerations that are fundamentally important in the use of drugs in patients with kidney disease View the entire collection here:
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@CJASN
CJASN
4 years
A meta-analysis found that although native kidney biopsy is an invasive diagnostic procedure, the rates of bleeding complications are low. Complications are more frequently seen after kidney biopsies of hospitalized patients with AKI.
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@CJASN
CJASN
11 months
Diarrhea is a common complication after kidney transplantation, often presenting as a diagnostic challenge for clinicians. This Kidney Case Conference: Nephrology Quiz & Questionnaire presents a case of norovirus in a kidney transplant recipient
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@CJASN
CJASN
2 years
Intravenous fluid administration is the mainstay for prevention for contrast-associated AKI. This study found that administration of a total volume of 1000 ml is associated with a similar risk of adverse outcomes as larger volumes of intravenous fluids
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@CJASN
CJASN
4 years
A new study found that the kidney failure risk equation ( #KFRE ) provided adequate to excellent discrimination in identifying patients with CKD likely to progress to kidney failure at the 2- and 5-year time points both overall and across etiologies.
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@CJASN
CJASN
1 year
Weighing the risks and benefits of clinical interventions is an everyday part of clinical practice. This article illustrates the decisions analysts must make when developing and evaluating risk prediction models, including the role of machine learning
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@CJASN
CJASN
1 year
IgA nephropathy can progress to kidney failure. This study found that outcomes in a large IgA nephropathy cohort are generally poor with few patients expected to avoid kidney failure in their lifetime @DannyGale_1 @IgAN_JBarratt @Moinsaleem @neilturn
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@CJASN
CJASN
1 year
IgG4-related kidney disease is a major manifestation of IgG4-related disease. This study found that IgG4-related kidney disease predominantly affected middle-aged males and manifested as tubulointerstitial nephritis with potential glomerular involvement
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@CJASN
CJASN
2 years
Peritoneal dialysis (PD) as an AKI treatment in adults was widely accepted in critical care settings well into the 1980s. This article highlights advantages and disadvantages of PD in critical care settings and indications and contraindications for its use
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@CJASN
CJASN
4 years
#Klotho in Clinical Nephrology: Diagnostic and Therapeutic Implications
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@CJASN
CJASN
3 years
Dietary potassium restriction in people receiving maintenance hemodialysis is standard practice and is recommended in guidelines. This study assesses the link between dietary potassium intake and mortality and whether hyperkalemia mediates this link
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@CJASN
CJASN
3 years
A “How I Treat” article summarizes a practical approach to initiating sodium-glucose transport protein 2 (SGLT2) inhibitors for people with type 2 diabetes and CKD based on the 2020 KDIGO Clinical Practice Guideline for Management of Diabetes in CKD.
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@CJASN
CJASN
1 year
IgG4-related kidney disease is a major manifestation of IgG4-related disease. This study found IgG4-related kidney disease manifested as tubulointerstitial nephritis with potential glomerular involvement @audard15 @Mercadal17 @Olivier_Thaunat
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@CJASN
CJASN
2 months
Liddle syndrome is a rare form of monogenic hypertension caused by gain-of-function variants in the epithelial Na+ channel (ENaC). This study found patients with genetically confirmed Liddle syndrome displayed a phenotypic spectrum
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@CJASN
CJASN
2 years
Tolvaptan slows expansion of kidney volume and kidney function decline in adults with ADPKD. This study found that tolvaptan exhibited pharmacodynamic activity in pediatric ADPKD. Aquaretic effects were manageable, with few discontinuations
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@CJASN
CJASN
3 years
A Review explores the theoretical benefits and risks of using intravenous albumin to mitigate intradialytic hypotension and/or enhance ultrafiltration. It summarizes the current evidence relating to this practice.
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@CJASN
CJASN
2 years
SGLT2-inhibitor-induced uric acid lowering may contribute to kidney protective effects of the drug-class in people with type 2 diabetes. This study investigates mechanisms of plasma uric acid lowering by SGLT2-inhibitors in people with type 2 diabetes
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@CJASN
CJASN
3 years
Fatigue is a common and debilitating symptom in patients with CKD. This Review consolidates information about the identification, epidemiology, pathophysiology, and potential treatments of fatigue in patients with CKD @UTSWNephrology
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@CJASN
CJASN
3 years
CJASN is proud to share our 2021 Editors' Choice articles! These 5 articles exemplify the highest potential to inform future research, change clinical practice, or influence public policy. All are freely accessible until February 28
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@CJASN
CJASN
2 years
Pseudo-hyperaldosteronism features hypokalemia, metabolic alkalosis, & suppressed renin. This Kidney Case Conference: How I Treat article presents a case of pseudo-hyperaldosteronism & review a schema for management @katierizzolo @NatNephro @sophia_kidney
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@CJASN
CJASN
2 years
AKI among individuals with cirrhosis is common, and it has been occurring more frequently over the last two decades. This Critical Care Nephrology and Acute Kidney Injury article discusses the management of AKI in cirrhosis @VelezNephHepato
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@CJASN
CJASN
1 year
SGLT2 inhibitors attenuate incident cardiovascular outcomes in conservatively managed CKD. This study found dapagliflozin was well tolerated and had nonaccumulating pharmacokinetic properties in patients with kidney failure on dialysis @LekaStaffico
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@CJASN
CJASN
2 years
The pathogenesis of hyponatremia in endocrine disorders is complex & often oversimplified. In this Kidney Case Conference: Nephrology Quiz & Questionnaire, Drs @melhoenig & @StewartLecker discuss treating a patient with severe hyponatremia @BIDMChealth
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@CJASN
CJASN
2 years
AKI is commonly encountered in patients with decompensated cirrhosis, and it is associated with unfavorable outcomes. This article discusses tailoring management of AKI in patients with liver disease to the specific underlying etiology @VelezNephHepato
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@CJASN
CJASN
7 months
AKI secondary to light chain cast nephropathy is common in patients with multiple myeloma at presentation and a time-critical emergency. This Kidney Case Conference: How I Treat article describes an approach to this problem
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@CJASN
CJASN
10 months
Crystalline nephropathies are an underdiagnosed cause of kidney disease characterized by intrarenal crystal deposition involving the tubulointerstitium. This Kidney Case Conference: How I Treat article proposes a practical approach to guide the diagnosis
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@CJASN
CJASN
2 years
Sepsis-associated AKI is a life-threatening complication linked to high morbidity & mortality in patients who are critically ill. This article summarizes laboratory and clinical studies, focusing on factors in the pathophysiology of sepsis-associated AKI
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@CJASN
CJASN
1 year
Thrombotic microangiopathies (TMAs) encompass a wide spectrum of ultra-rare diseases resulting from endothelial injury. This study shows secondary TMAs represent the main cause of TMA & are linked to high risk of death & progression to kidney failure
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@CJASN
CJASN
1 year
Mg2+, the fourth most abundant cation in the body, serves as a cofactor for about 600 cellular enzymes. This Review focuses on the nature of transport in the gut and renal tubule and how they are integrated into an understanding of human Mg2+ physiology
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@CJASN
CJASN
2 years
AKI is often multifactorial, especially in the hospitalized patient. This Review discusses the pathophysiology of three etiologies that cause AKI: kidney hypoperfusion, abdominal compartment syndrome, and urinary tract obstruction @IUKidney
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@CJASN
CJASN
5 months
AKI is a common complication of rhabdomyolysis and is associated with high morbidity and mortality. This Kidney Case Conference: How I Treat article presents management strategies for rhabdomyolysis-induced AKI @javo_neyra
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@CJASN
CJASN
2 years
ANCA-associated vasculitides affect the kidneys with aggressive inflammation. This Kidney Case Conference: How I Treat article discusses the use of rituximab in severe ANCA-associated glomerulonephritis, focusing on frail & elderly populations @BrixSilke
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@CJASN
CJASN
2 years
AKI is a syndrome that is often multifactorial, especially in the hospitalized patient. This Review discusses the pathophysiology of three etiologies that cause AKI: kidney hypoperfusion, abdominal compartment syndrome, and urinary tract obstruction
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@CJASN
CJASN
2 years
Inherited tubulopathies are characterized by impaired function of one or more of transport molecules. This Review discusses the genetic aspects of tubulopathies & how genetic investigations and kidney physiology have crossfertilized each other @CamyLG86
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@CJASN
CJASN
1 year
Large-scale clinical trials have shown SGLT2 inhibitor prevents long-term kidney function decline and reduces the risks of adverse kidney outcomes. This study found several background medications were linked to the initial eGFR dip after SGLT2i initiation
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@CJASN
CJASN
1 year
Diarrhea is a common complication after kidney transplantation with causes, often presenting as a diagnostic challenge for clinicians. This article presents a case of norovirus in a transplant recipient @kidneybeaN12zu @kidneyshower
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@CJASN
CJASN
10 months
ADPKD is a genetic disorder characterized by kidney cyst formation and progressive kidney function loss. This Review discusses the available evidence supporting the efficacy and safety of dietary interventions in ADPKD @fouadchebib @KristenlNowak @ndahl48
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@CJASN
CJASN
4 years
Medications that slow kidney failure and reduce heart diseases are under-prescribed for patients with diabetic kidney disease. A new study provides a prescription algorithm to guide the use of SGLT2i and GLP-1 RA.
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@CJASN
CJASN
3 years
Diabetic kidney disease is a devastating complication of diabetes. This Review highlights advances in treatment, challenges, & solutions to advance kidney health, and introduces the launch of the Diabetic Kidney Disease Collaborative at ASN
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@CJASN
CJASN
8 months
Tumor lysis syndrome results from the spontaneous or therapy-induced destruction of malignant cells, releasing intracellular content into extracellular space. This article discusses the presentation and treatment of tumor lysis syndrome
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@CJASN
CJASN
2 years
How does the new KDIGO 2021 blood pressure guideline affect the management of BP in patients with CKD? This Kidney Case Conference: How I Treat article presents a case that takes these new guidelines into account @edgarvlermamd
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@CJASN
CJASN
2 years
Individuals with congenital anomalies of the kidney and urinary tract (CAKUT) are an important patient category. This Review discusses the molecular etiology of CAKUT & the available genome diagnostic modalities in the clinical care of patients with CAKUT
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@CJASN
CJASN
2 years
This study suggests that treatment with the combination of ACE inhibitors/ARB and SGLT2 inhibitor in patients with albuminuric CKD without diabetes could substantially increase kidney failure–free survival @DavidCWheeler2 @gchertow @BWHKidney
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@CJASN
CJASN
2 years
Advances in cancer therapy have improved patient survival; however, AKI is common in patients with cancer. This Review highlights the epidemiology of AKI in critically ill patients with cancer, risk factors for AKI, & common pathologies linked to therapies
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@CJASN
CJASN
1 year
Intermittent hemodialysis is a cornerstone of extracorporeal KRT in the ICU. This Critical Care Nephrology and AKI article reviews important aspects of the management of intermittent hemodialysis in patients who are critically ill @MarkCanney @edclark75
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@CJASN
CJASN
1 month
The link between cardiac and kidney dysfunction has received increasing attention over the past two decades. This Review discusses the methodologic and practical problems inherent to the current classification of cardiorenal syndrome @ZoccaliCarmine
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@CJASN
CJASN
2 years
Alport syndrome is the second most common cause of genetic kidney failure after polycystic kidney disease. This Review discusses digenic Alport syndrome, with a focus on the pathogenesis and management of different types of digenic inheritance
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@CJASN
CJASN
2 years
Acid-base disorders are common in the ICU. By utilizing a systematic approach to their diagnosis, it is easy to identify both simple & mixed disturbances. This Review focuses on those disorders that occur in the critically ill
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@CJASN
CJASN
4 months
Conversion to a belatacept-based immunosuppression is used as a calcineurin inhibitor (CNI) avoidance strategy. This study shows that conversion to belatacept post-transplant was associated with lower risk of graft failure and acceptable safety outcomes
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CJASN
4 years
Peer review is integral to publishing high-quality, valid research. CJASN would like to recognize the top 5 reviewers of 2020: Dr. Ziyad Al-Aly, Dr. Raymond Hsu, Dr. Kenar Jhaveri, Dr. Matthew Rivara, and Dr. Deirdre Sawinski. Each day, we'll share their thoughts on peer review.
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