Barry Singer MD 🧠 @drbarrysinger Twitter profile

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Barry Singer MD 🧠

1 day

Mind over MS🎙️ New MS Living Well Podcast! @tcspeaks32 shares his insights from college football player to multiple sclerosis advocate! 🍎 @MustStopMS @themsguide @MarkWebb_ @Brandon_Beaber @JulianGumbo @MSassociation @NerdyNeuroMD

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Barry Singer MD 🧠

@drbarrysinger

14 days

New McDonald Criteria for diagnosis MS. @XMontalban : New criteria includes RIS under certain circumstances, central vein sign, neurofilament light chain and optic nerve. #ECTRIMS2024

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Barry Singer MD 🧠

@drbarrysinger

1 year

WOW! @mcuban making a substantial impact on affordability of generic #MS medications. This price of #teriflunomide (generic #Aubagio ) is phenomenal for those patients with out-of-pocket costs. @costplusdrugs Grateful! @AaronBosterMD @Brandon_Beaber @MustStopMS @DrJim4MS @DocforMS

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Barry Singer MD 🧠

@drbarrysinger

5 years

#MSCOVID19 Awesome news. First report on #Ocrevus #ocrelizumab today from our global colleagues.

NeuroImmunology Club

@NeuroImmunology

5 years

@drbarrysinger @J_SastreGarriga @C_OrejaGuevara @bart_professor @KlausSchmierer @GavinGiovannoni @SKriegerMD Have one patient with ocrelizumab infected. Doing fine. Flu-like symptoms but doing well

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Barry Singer MD 🧠

@drbarrysinger

14 days

Thouvenot: Largest therapeutic trial of vitamin D therapy in #MS . Oral vitamin D 100,000 IU every two weeks reduced disease activity by 34% in CIS patients and in early RRMS. #ECTRIMS2024

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Barry Singer MD 🧠

@drbarrysinger

5 years

Have you heard about any #MS patients being infected with #COVID19 #coronavirus infections? Important that we share global experience to give advice and make key treatment decisions. @C_OrejaGuevara @J_SastreGarriga @bart_professor @KlausSchmierer @GavinGiovannoni @SKriegerMD

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Barry Singer MD 🧠

@drbarrysinger

4 years

Just got 1st dose #COVID19 @pfizer vaccine!💪Protecting my #MS patients, colleagues & family from infection. #CrushCOVID #MSCOVID19 @MustStopMS @CathyChes @MarkWebb_ @TheGirlWithMS @AaronBosterMD @Brandon_Beaber @C_OrejaGuevara @DraganaObrado20 @KlausSchmierer @RumaizaAlyafeai

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Barry Singer MD 🧠

@drbarrysinger

3 years

THANK YOU for encouraging others to get vaccinated to protect people living with multiple sclerosis and sharing your diagnosis, @JohnKingCNN . I’m a long-term fan & MS doc. @AaronBosterMD @Brandon_Beaber @MustStopMS @MSassociation @CathyChes @TheGirlWithMS @MSViewsandNews @shiftms

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Barry Singer MD 🧠

@drbarrysinger

3 years

The decision to unmask the vaccinated general population really leaves behind those immunosuppressed. Many of my patients are very private about their MS diagnosis and chose to be on highly effective medications. If you see someone still wearing a mask, respect their privacy.😷

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Barry Singer MD 🧠

@drbarrysinger

2 years

Have walking trouble with #MS ? 🚶‍♀️ #Dalfampridine (generic Amprya) may help. Available @costplusdrugs @mcuban for only $19.80 for one month supply. Now much more affordable for many people living with #MS . Spread the word👍 @AaronBosterMD @Brandon_Beaber @MustStopMS @CathyChes

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Barry Singer MD 🧠

@drbarrysinger

13 days

Great news! Hercules trial results in non-relapsing secondary-progressive #MS #SPMS . #Tolebrutinib reduced 6-month disability progression by 31% compared to placebo (P=0.0026). Liver monitoring will be very important. #ECTRIMS2024

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Barry Singer MD 🧠

@drbarrysinger

2 years

Red Flags 🚩 that patient does not have #MS . High CSF protein, high CSF cellularity and lack of OCB. Brainstem/cerebellar lesions can be due to MOGAD, NMO, Sarcoid, PML, Alexander’s, CLIPPERS and even listeria infection. #ACTRiMS #ACTRIMSForum

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Barry Singer MD 🧠

@drbarrysinger

2 years

Need new treatments to be tested in #remyelination studies ASAP! People living with #MS are eager to participate. Agree? Ready to collaborate with global researchers!! @MustStopMS @themsguide @CathyChes @C_OrejaGuevara @KlausSchmierer @AaronBosterMD @Brandon_Beaber

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Barry Singer MD 🧠

@drbarrysinger

4 years

Bizarre. I just got my 2nd dose of @pfizer #COVID19 vaccine. Then I started experiencing abnormal muscle movements... #HappyDance #GetVaccinated #CrushCOVID @CathyChes @TheGirlWithMS @AaronBosterMD @Brandon_Beaber @RanyAburashed @napolineuro @DrJNicholas @MustStopMS @DanJenDig

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Barry Singer MD 🧠

@drbarrysinger

1 year

Arrived at @ECTRIMS #MSMilan2023 ready to learn and share the latest research news on multiple sclerosis #MS ! Goal is to improve the lives of those living with MS and hopefully preventing the disease! I’ll be live tweeting as usual.

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Barry Singer MD 🧠

@drbarrysinger

3 years

Risk of #MS increased 32-fold after infection with #Epstein -Barr virus #EBV in study of 10 million active-duty young adults in US military. @AaronBosterMD @Brandon_Beaber @GavinGiovannoni @XMontalban @KlausSchmierer @C_OrejaGuevara @MustStopMS @themsguide

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Barry Singer MD 🧠

@drbarrysinger

15 days

#ECTRIMS2024 >8000 attendees focused on seeking breakthroughs in treatment and, ultimately, stopping multiple sclerosis. Looking forward to new clinical trial results for secondary progressive #MS #SPMS !!!

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Barry Singer MD 🧠

@drbarrysinger

14 days

Bove: SOPRANINO study. Ocrelizumab Ocrevus was undetectable in blood of infants being nursed by mothers with MS being treated with this monoclonal antibody. Also, B cell counts in newborns were reassuringly normal (important for infant vaccines). #ECTRIMS2024

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Barry Singer MD 🧠

@drbarrysinger

4 years

#COVID19 @pfizer vaccine given to patients with autoimmune disease requiring treatment; no info yet. Vaccine mounted good T cell response; 👍 for people on B cell depleting meds. Safety➕. #MSCOVID19 @GavinGiovannoni @MustStopMS @AaronBosterMD @XMontalban

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Barry Singer MD 🧠

@drbarrysinger

5 years

Ready for #ECTRIMS2019 ! Ready to share advances in #MS and will be LIVE tweeting as usual! Particularly interested in #remyelination ( #myelin repair)! People with #MS are counting on ACTION from us neurologists & scientists to pave the way for a new generations of treatment!

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Barry Singer MD 🧠

@drbarrysinger

2 years

National Swedish #MS Registry study. #EBV EBNA1 antibodies appear 10-15 years before onset of disease. sNfL levels rise 5-10 years prior to #MS onset. #ECTRIMS2022 @ECTRIMS

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Barry Singer MD 🧠

@drbarrysinger

4 years

Starting high efficacy #DMT at #MS onset can dramatically reduce the risk of disability progression compared to starting with lower efficacy medications. Carpe Diem! @MSBase_Registry data. @GavinGiovannoni just presented at #MSVirtual2020 .

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Barry Singer MD 🧠

@drbarrysinger

5 years

@J_SastreGarriga @C_OrejaGuevara @bart_professor @KlausSchmierer @GavinGiovannoni @SKriegerMD @XMontalban @paolopreziosa @TZiemssen @olgacicc @AngelPSempere @nikosevangelou3 @vjokubaitis @SaraLlufriu @neuronavasms @MarinaC_Dyb recommended picking hastag for info regarding #MS patients affected by #COVID19 . Let’s use #MSCOVID19 . People with MS around the globe are depending on us to out smart this #coronavirus . We are in unprecedented times. @AaronBosterMD @Brandon_Beaber @JackOsbourne

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Barry Singer MD 🧠

@drbarrysinger

2 years

After 3 years of mandatory masking 😷, @BJC_HealthCare just announced going to a mask optional policy starting March 22. I’m still happy to wear a mask with my #MS patients who prefer this extra measure of safety. Thoughts? @MustStopMS @themsguide @TheGirlWithMS @CathyChes

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Barry Singer MD 🧠

@drbarrysinger

5 years

Received an AWESOME holiday gift today from a grateful #MS patient!! An amazing honor to positively impact the lives of others! Happy and healthy new year! ⁦ @AaronBosterMD ⁩ ⁦ @SKriegerMD ⁩ ⁦ @DocforMS ⁩ ⁦ @MustStopMS ⁩ ⁦ @CathyChes ⁩ ⁦ @TheGirlWithMS ⁩

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Barry Singer MD 🧠

@drbarrysinger

3 years

On Call at hospital. Another #COVID19 wave. Full moon. It’s all OK. Still glad to be a doctor, making a positive impact on the lives of others. @AaronBosterMD @Brandon_Beaber @KlausSchmierer @C_OrejaGuevara @MustStopMS @CathyChes 😷 Booster up!

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Barry Singer MD 🧠

@drbarrysinger

4 years

Surge has definitely started. More & more #MS patients becoming #COVID19 positive in my center. Hunker down everyone!! Be super careful! Vaccine coming but it’s going to be a long winter. #MSCOVID19 @MustStopMS @CathyChes @TheGirlWithMS @AaronBosterMD @ActiveMSer @MSViewsandNews

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Barry Singer MD 🧠

@drbarrysinger

4 years

1540 #MS patients with #COVID19 . Treatment with B-cell depleting medications #rituximab & #ocrelizumab associated with higher rates of ICU admission, but not increased risk of death. @MSIntFederation #MSVirtual2020 @MustStopMS @MSViewsandNews @AaronBosterMD @shiftms #MSCOVID19

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Barry Singer MD 🧠

@drbarrysinger

15 days

Tremlett: #MS prodrome symptoms begin at least 5 years before first neurological attack. May lead to early diagnosis of #MS , especially in patients with MS risk factors. #ECTRIMS2024

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Barry Singer MD 🧠

@drbarrysinger

2 years

#Briumvi #ublituximab just FDA-approved for #MS . Routine treatment only 1 hour IV every 6 months. Reduced relapses 49-59% & active contrast brain lesions 96-97% compared to oral teriflunomide. Learn more: @AaronBosterMD @Brandon_Beaber @DrJim4MS @DocforMS

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Barry Singer MD 🧠

@drbarrysinger

2 years

🌎🔬Ready to learn/share the latest #MS research at #ECTRIMS2022 @ECTRIMS in Amsterdam. Will be LIVE tweeting starting tomorrow. Looking forward to seeing colleagues! @C_OrejaGuevara @KlausSchmierer @AaronBosterMD @bart_professor @MStranslate @MSViewsandNews

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Barry Singer MD 🧠

@drbarrysinger

13 days

Patrucco: McDonald MS criteria is sensitive in LATAM but not very specific. Very important to consider differential diagnoses, especially infectious and nutritional diseases. #ECTRIMS2024

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Barry Singer MD 🧠

@drbarrysinger

15 days

Hello #MS Global 🌍 Community! Looking forward to real-time posting new #MS research at #ECTRIMS2024 in Copenhagen starting today! @themsguide @MustStopMS @Brandon_Beaber @AaronBosterMD @RachelHorne19 @CathyChes @TheGirlWithMS @MarkWebb_ @DrJim4MS @ECTRIMS

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Barry Singer MD 🧠

@drbarrysinger

3 years

Time to celebrate the lives of those living with #MS globally and their caregivers & supporters! #WorldMSDay #WorldMSDay2021 @WorldMSDay @CathyChes @TheGirlWithMS @Brandon_Beaber @AaronBosterMD @MarkWebb_ @DJS_KBO @iConquerMS @C_OrejaGuevara @KlausSchmierer @anneke_vdw @shiftms

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Barry Singer MD 🧠

@drbarrysinger

2 years

Should radiological isolated syndrome #RIS ( #MS lesions on MRI but no classic relapse) be treated? Interesting #ACTRIMS2023 debate. @XMontalban emphasized MRI should have classic MRI features. Risk factors for conversion of RIS to CIS👇. Panelists:YES, MS exists without symptoms!

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Barry Singer MD 🧠

@drbarrysinger

3 years

Hi, all! Happy to share the latest #MS research news from #ACTRIMS . I'll be live tweeting the next 3 days. Time to improve care for people living with multiple sclerosis. 👍👍 Great to see my colleagues again!! @MustStopMS @themsguide @TheGirlWithMS @CathyChes @MSViewsandNews

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Barry Singer MD 🧠

@drbarrysinger

3 years

Does #COVID19 vaccination trigger MS relapses? Achiron: In 555 #MS patients that received 1st dose and 435 patients with 2nd dose, no increase risk of relapse. #ECTRIMS2021 @MustStopMS @CathyChes @TheGirlWithMS @themsguide @MarkWebb_ @DanJenDig @shiftms @MSassociation

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Barry Singer MD 🧠

@drbarrysinger

4 years

Oligo precursor cells #OPCs can regenerate myelin replacing lost myelin but also creating myelin in new locations. Regeneration variable depending on layer of cortex. Barancik Prize Lecture: Dwight Bergles PhD #ACTRIMS @ACTRIMS #remyelination

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Barry Singer MD 🧠

@drbarrysinger

3 years

#BTK inhibitor #tolebrutinib 60 mg reduced enhancing lesions by 93% and new/enlarging T2 lesions by 89% over 12 weeks in #MS patients with highly active disease. #AANAM @KlausSchmierer @C_OrejaGuevara @AaronBosterMD @Brandon_Beaber @napolineuro @MustStopMS @MSViewsandNews

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Barry Singer MD 🧠

@drbarrysinger

4 years

Happy & Healthy 2021 #MS Community! For 2021👉 vaccinations, advancing MS care, collaborating with global colleagues & recording more podcasts @MustStopMS @AaronBosterMD @Brandon_Beaber @CathyChes @TheGirlWithMS @C_OrejaGuevara @KlausSchmierer @MarkWebb_

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Barry Singer MD 🧠

@drbarrysinger

5 years

My New Blog Post: Living with #MS in #Coronavirus #COVID -19 Pandemic. Know your RISKS & PROTECT YOURSELF. @GavinGiovannoni @MustStopMS @TheGirlWithMS @AaronBosterMD @CathyChes @lisaemrich @mstranslate @DanJenDig @iconquerMS @Brandon_Beaber jpg:anikolleshi

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Barry Singer MD 🧠

@drbarrysinger

14 days

Zipp: #CAR -T is a potential new treatment for multiple sclerosis #MS by deeply depleting B cells in the central nervous system. Risks include cytokine release syndrome and immune effector cell-associated neurotoxic syndrome. #ECTRIMS2024

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Barry Singer MD 🧠

@drbarrysinger

5 years

Subcutaneous monthly, B-cell depleting #ofatumumab 20 mg reduced relapses by 51-59%, risk of disability progression by 34% and new T2 lesions by 82-84.5% compared to #teriflunomide 14 mg oral daily in ASCLEPIOS studies enrolling 1882 #MS patients. #ECTRIMS2019

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Barry Singer MD 🧠

@drbarrysinger

3 years

After 2 years of being super careful...just #OMICRONed Sore throat, chills and husky voice. Stay safe out there! 😷 @AaronBosterMD @Brandon_Beaber @CathyChes @TheGirlWithMS @MustStopMS @themsguide

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Barry Singer MD 🧠

@drbarrysinger

2 years

It's #WorldMSDay . 🌍 A great opportunity to connect with #MS community. 🌞 Reach out and support those living with multiple sclerosis! 🤗 @WorldMSDay #MSconnections @MustStopMS @themsguide @CathyChes @TheGirlWithMS @AaronBosterMD @Brandon_Beaber @DanJenDig @MarkWebb_ @deedubs57

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Barry Singer MD 🧠

@drbarrysinger

3 years

#Ocrelizumab benefits examined in @MSBase_Registry . @anneke_vdw : 1000 relapsing patients studied. 90.5% were relapse-free at 2 years. Only 7.2% had disability progression. #ECTRIMS2021 @napolineuro @DocforMS @DrJNicholas @C_OrejaGuevara

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Barry Singer MD 🧠

@drbarrysinger

3 years

St. Louis #COVID19 hospitalization on the rise. 😷 Mask up. Protect the multiple sclerosis community and others at risk. Not too late to vaccinate!

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Barry Singer MD 🧠

@drbarrysinger

3 years

NEW #COVID19 PREVENTION for those with #MS that are immunocompromised! #EVUSHELD I.M. injection granted EUA by FDA. Tixagevimab & cilgavimab (the active components) are monoclonal antibodies that bind to spike protein of SARS-CoV-2 #COVID19 virus. INFO:

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Barry Singer MD 🧠

@drbarrysinger

3 years

NYU #MSCOVID19 data #AANAM poster: In 1635 #MS patients, specific #DMT #MS treatments were NOT associated with increased risk of #COVID19 infection or hospitalization. @XMontalban @GavinGiovannoni @KlausSchmierer @C_OrejaGuevara @AaronBosterMD @Brandon_Beaber @DraganaObrado20

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Barry Singer MD 🧠

@drbarrysinger

4 years

Phase 2 clinical trial of #BTKi inhibitor #SAR442168 in #MS just presented by @SanofiGenzyme in #MS . Enters CNS & affects B cells and microglia. 85% reduction on enhancing & 89% reduction on new/enlarging T2 lesions on 60 mg vs placebo. @AaronBosterMD @SKriegerMD @KlausSchmierer

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Barry Singer MD 🧠

@drbarrysinger

4 years

Phase 2 AFFINITY #opicinumab study didn’t meet primary endpoint & key secondary outcome measures. Biogen will not continue further development of opicinumab in relapsing #MS . Lost a #remyelination battle, but will win war against MS! @AaronBosterMD @MustStopMS @GavinGiovannoni

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Barry Singer MD 🧠

@drbarrysinger

4 years

#Kesimpta #ofatumumab FDA-approved for #MS . Injected under skin every 4 weeks. Depletes B cells. Reduces relapses by 51-58% and contrast MRI lesions 94-97% compared to #Aubagio . @MustStopMS @AaronBosterMD @Brandon_Beaber @MSViewsandNews @TheGirlWithMS

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Barry Singer MD 🧠

@drbarrysinger

4 years

Vermersch: #Mastinib , oral tyrosine kinase inhibitor target microglia and mast cells, in #PPMS & Non-active #SPMS Phase 3 results: 4.5 mg/kg/d reduced confirmed disability progression by 37%. Risks included maculo-paular rash, neutropenia and GGT increase. #MSVirtual2020

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Barry Singer MD 🧠

@drbarrysinger

5 years

Corresponded with Prof. Giancarlo Comi in Milan. Using @MSIntFederation document recommendations. Starting a survey in Italy to evaluate the frequency of #MS patients positive for #COVID19 and disease status. @J_SastreGarriga @paolopreziosa #MSCOVID19

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Barry Singer MD 🧠

@drbarrysinger

2 years

#Ofatumumab 4 year data showed stable IgG levels, no increase in malignancy and favorable #COVID19 outcomes. #AANAM

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Barry Singer MD 🧠

@drbarrysinger

2 years

Okuda: ARISE, first #RIS randomized controlled trial. Over 80% reduction in first demyelinating attack for the RIS patients on dimethyl fumarate compared to placebo. Good MRI data below. #ECTRIMS2022 @ECTRIMS @DrJNicholas @J_SastreGarriga @DocforMS @KlausSchmierer @themsguide

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Barry Singer MD 🧠

@drbarrysinger

4 years

👍ULTIMATE 1 & 2 Phase 3 Results: #Ublituximab reduced relapses 60% & 50% compared to #teriflunomide #Aubagio . 1 hour infusion every 6 months after 1st 4 hour infusion. B-cell depleting agent. @TGTherapeutics @AaronBosterMD @KlausSchmierer @XMontalban @Brandon_Beaber @MustStopMS

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Barry Singer MD 🧠

@drbarrysinger

4 years

#ASCLEPIOS I & II trials published. #Ofatumumab under skin every 4 weeks reduced relapses 51-58%, disability progression 34-35%, contrast MRI lesions 94-97% & NfL (24 months) 23-24% vs. #teriflunomide #Aubagio @AaronBosterMD @Brandon_Beaber @KlausSchmierer

Ofatumumab versus Teriflunomide in Multiple Sclerosis | NEJM

Ofatumumab, a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B cells. Teriflunomide, an oral inhibitor of pyrimidine synthesis, reduces T-cell and B-cell activation. The relative ...

www.nejm.org

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Barry Singer MD 🧠

@drbarrysinger

1 year

Awesome to be at ⁦ @MSassociation ⁩ benefit as a Board Member with ⁦ @SelmaBlair ⁩ to raise funds and advocacy for those living with #MS . 👍⁦ @CathyChes ⁩ ⁦ @themsguide ⁩ ⁦ @TheGirlWithMS ⁩ ⁦ @MustStopMS ⁩ ⁦ @AaronBosterMD ⁩ ⁦ @Brandon_Beaber ⁩

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Barry Singer MD 🧠

@drbarrysinger

15 days

Cohen: Radiological Isolated Syndrome #RIS is the finding of lesions suggestive demyelination without typical #MS neurological symptoms. Is RIS simply pre-symptomatic MS?? #ECTRIMS2024

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Barry Singer MD 🧠

@drbarrysinger

3 years

Great hosting my colleague & friend Dr. Mitzi Williams @NerdyNeuroMD at my center. She shared with my team specific ways to improve #MS patient care, particularly for the African-American community. @MustStopMS @DrJNicholas @IntNatlWiMS @nclark140 @sumadshah @deedubs57

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Barry Singer MD 🧠

@drbarrysinger

4 years

Great news! #Mastinib , an oral treatment, slowed disability worsening in PROGRESSIVE #MS patients in Phase 3 Trial (301 #MS patients). @MustStopMS @MSViewsandNews @AaronBosterMD @Brandon_Beaber @TheGirlWithMS @CathyChes @MSassociation @ActiveMSer 👍👍👍

Barry Singer MD 🧠

@drbarrysinger

4 years

Vermersch: #Mastinib , oral tyrosine kinase inhibitor target microglia and mast cells, in #PPMS & Non-active #SPMS Phase 3 results: 4.5 mg/kg/d reduced confirmed disability progression by 37%. Risks included maculo-paular rash, neutropenia and GGT increase. #MSVirtual2020

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Barry Singer MD 🧠

@drbarrysinger

5 years

#Burman : Hematopoietic Stem Cell Transplant #HSCT highly effective. Data from MIST Trial supportive. #HSCT reduced risk of disability better than approved disease-modifying therapy. Modern mortality rates 0.3%. #ECTRIMS2019

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Barry Singer MD 🧠

@drbarrysinger

3 years

PEOPLE article about @SelmaBlair , who shares her personal struggles & advocates for the #MS Community. Appreciate the collaboration with @MSassociation #MSAA to help improve lives of those living with MS! @MSAA_CEO @CathyChes @AaronBosterMD @MustStopMS

Selma Blair 'Feels Like a New Person' After Life-Altering Stem Cell Transplant for her MS

Selma Blair talks to PEOPLE about her life-altering stem cell transplant for her MS

people.com

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Barry Singer MD 🧠

@drbarrysinger

6 years

Greater than 9400 people passionate about improving the lives of those with #MS attending #ECTRIMS2018 in Berlin. Should be enough brain power for leaps in innovations. Our patients need advancement!

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Barry Singer MD 🧠

@drbarrysinger

2 years

Piccio: Randomized Clinical Trial of Intermittent Calorie Restriction in People with #MS . 2 days a week of 400-500 caloric restriction associated with decrease #BMI , lower pro-inflammatory #leptin , increase in T regulatory cells & better SDMT scores. #ACTRIMS2023 #ACTRIMSForum

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Barry Singer MD 🧠

@drbarrysinger

4 years

We all can make a positive impact on this world. 👍 ⁦ @CathyChes ⁩ ⁦ @AaronBosterMD ⁩ ⁦ @MSViewsandNews ⁩ ⁦ @MustStopMS ⁩ ⁦ @MSAA_CEO ⁩ @lkay54 ⁦ @DanJenDig ⁩ ⁦ @SKriegerMD ⁩

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Barry Singer MD 🧠

@drbarrysinger

5 years

. @MSIntFederation & Multiple Sclerosis Data Alliance are spearheading a worldwide initiative for #MSCOVID19 database/registry collection of cases. >20 organizations involved globally incl @eumsplatform @MSBase_Registry @EuropeanCharcot @UKMSRegister @MENACTRIMS Glad 2 B involved!

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Barry Singer MD 🧠

@drbarrysinger

19 days

Ocrevus #Zunovo was just FDA-approved. Ocrevus given subcutaneously (under skin) over 10 minutes. 60-minute observation after 1st dose, then only 15 minutes. Requires premeds. @DrJim4MS @Brandon_Beaber @DrJNicholas @DocforMS @MustStopMS Read more:

Genentech: Press Releases | Friday, Sep 13, 2024

Discover the latest news about our company, our products, our policies, and our people.

www.gene.com

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Barry Singer MD 🧠

@drbarrysinger

4 years

Does my #MS medication #DMT affect my ability to respond to #vaccines ? #MSCOVID19 Just Posted to My Blog: @shiftms @MarkWebb_ @MSViewsandNews @TheMSKittylady @CathyChes @TheGirlWithMS @DJS_KBO @ActiveMSer @MustStopMS @nclark140 @LisaEmrich @MStranslate

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Barry Singer MD 🧠

@drbarrysinger

2 years

Two ongoing #vaccine trials to prevent #EBV Epstein-Barr infection. Goal: To prevent #MS and reduce disease activity. 👉Today I’m doing a Twitter takeover for @neurology_live ! @AaronBosterMD NerdyNeuroMD @Brandon_Beaber @DocforMS @KlausSchmierer @MustStopMS @themsguide

NeurologyLive®

@neurology_live

2 years

Jeffrey Cohen @NIH : 2 trials to prevent #EBV infection. gp350 nanoparticle trial at NIH and mRNA @moderna_tx . If #EBV infection can be prevented, #MS may be prevented. Most exposed in #EBV childhood. Reduced #EBV viral load may reduce illness. #ACTRIMS2023 @drbarrysinger

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Barry Singer MD 🧠

@drbarrysinger

2 years

Hulst: Cognitive rehab should be implemented in #MS patients prior to cognitive impairment or with only mild impairment, rather than waiting only for moderate to severe cognitive impairment. #ECTRIMS2022 🧠

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Barry Singer MD 🧠

@drbarrysinger

5 years

Preparing for #MSCOVID19 in Midwest USA. All virtual appointments today @zoom_us on iPad, routine MRIs delayed, washable scrubs (including old pair from @nyphospital residency) & buzz cut (delaying next hair cut). Large majority of my #MS patients staying/working from home.

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Barry Singer MD 🧠

@drbarrysinger

2 years

Black and Hispanic #MS patients have higher disability (EDSS) & more likely to be unemployed from MS than white patients; also less likely to have private insurance. Improve health equity now! Presented by @OrlandoMDMPH #AANAM @NerdyNeuroMD @AaronBosterMD @MustStopMS @deedubs57

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Barry Singer MD 🧠

@drbarrysinger

3 years

#Antibody but not #T -cell responses are attenuated in #MS patients on #Ocrevus #ocrelizumab after SARS-CoV-2 COVID-19 infection. #AANAM P15.014 @AaronBosterMD @Brandon_Beaber @KlausSchmierer @GavinGiovannoni @XMontalban @C_OrejaGuevara @SKriegerMD @anneke_vdw @RumaizaAlyafeai

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Barry Singer MD 🧠

@drbarrysinger

3 years

Looking for nutrition info for multiple sclerosis? Guests: Drs. Mowery & Katz Sand, #MS #Diet experts, on new MS Living Well podcast. 🍎: @DrJim4MS @DocforMS @sumadshah @napolineuro @MSViewsandNews @MStranslate @ConorKerley

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Barry Singer MD 🧠

@drbarrysinger

3 years

#MS Cause & Cure 🎧 New MS Living Well Podcast Harvard Docs Weiner & Ascherio (Head researcher on Epstein-Barr Virus #EBV & MS). 🍎 @MustStopMS @AaronBosterMD @Brandon_Beaber @TheGirlWithMS @CathyChes @MarkWebb_ @ActiveMSer @DocforMS

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Barry Singer MD 🧠

@drbarrysinger

5 years

#MSCOVID19 anxiety for people with #MS and healthcare providers is understandable high. Remember you are not alone and we all have each other's back. @ICanWithMS @CathyChes @TheGirlWithMS @MustStopMS @PositiveWithMS @MSassociation @MSIntFederation JPG: Sincerely Media; Unsplash

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Barry Singer MD 🧠

@drbarrysinger

3 years

Sormani: Italian COVID-19 outcomes in #MS reviewed. Higher risk of severe #COVID19 on B-cell depleting medications, especially after 2 years of treatment. Interferon protective. #AANAM @C_OrejaGuevara @KlausSchmierer @MustStopMS @AaronBosterMD @Brandon_Beaber @DraganaObrado20

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Barry Singer MD 🧠

@drbarrysinger

4 years

Half of my patients I saw today in my center physically or virtually had received at least one #COVID19 vaccine dose!! Progress! #CrushCOVID @MustStopMS @Brandon_Beaber @AaronBosterMD @DJS_KBO @MarkWebb_ @CathyChes @TheGirlWithMS @ActiveMSer @shiftms #MSCOVID19

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Barry Singer MD 🧠

@drbarrysinger

4 years

People with low Vitamin D levels (<20 ng/ml or 125 nmol/L) are more likely to become COVID-19 positive. Good vitamin D levels also associated with less #MS relapses & MRI activity. @MustStopMS @MSViewsandNews @CathyChes @TheGirlWithMS @AaronBosterMD

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Barry Singer MD 🧠

@drbarrysinger

3 years

Ready to learn and share! 👍 I’ll be live tweeting again for 3 days starting tomorrow! 🌍 Global #MS meeting #ECTRIMS2021 @ectrimscongress @AaronBosterMD @Brandon_Beaber @KlausSchmierer @C_OrejaGuevara @anneke_vdw @RumaizaAlyafeai @MustStopMS @CathyChes @TheGirlWithMS @themsguide

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Barry Singer MD 🧠

@drbarrysinger

1 month

😃Good news for patients with secondary-progressive multiple sclerosis! Looking forward to live X posting the #tolebrutinib Hercules results Sept 20 @ECTRIMS #ECTRIMS2024 @themsguide @MustStopMS @CathyChes @RachelHorne19 @C_OrejaGuevara @anneke_vdw @MarkWebb_ @bart_professor

Barry Singer MD 🧠

@drbarrysinger

1 month

Encouraging topline results regarding #tolebrutinib ! In Hercules trial, tolebrutinib delayed disability progression vs. placebo in secondary-progressive MS patients without relapses. Thanks to our center's patients that participated in the trials!

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Barry Singer MD 🧠

@drbarrysinger

4 years

Will be LIVE meeting tweeting the next 3 days! The largest global multiple sclerosis meeting goes virtual. @ectrimscongress @ACTRIMS TIME FOR PROGRESS for all those living with #MS ! 👍 #MSVirtual2020 @MustStopMS @MSViewsandNews @MyMSTeam @CathyChes @TheGirlWithMS @AaronBosterMD

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Barry Singer MD 🧠

@drbarrysinger

3 years

John Dystel Prize Lecture at #AANAM @XMontalban of @cemcat_em presents personalization strategies of treatment of #MS and improving earlier diagnosis. @J_SastreGarriga @MarTintore @mssociety Bravo 👏

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Barry Singer MD 🧠

@drbarrysinger

4 years

Light at end of the tunnel. ☀️ Just hunker down a little bit longer. 😷 Us healthcare providers don’t need any more #COVID19 patients. 🦠Got hospital call this weekend. @MustStopMS @AaronBosterMD @Brandon_Beaber @CathyChes @ActiveMSer @TheGirlWithMS @DocforMS @shiftms #MSCOVID19

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Barry Singer MD 🧠

@drbarrysinger

4 years

Gut microbiome #MS study in Japan demonstrates significant differences between relapsing-remitting #RRMS and secondary-progressive #SPMS . More oxidative stress & pro-inflammatory Th17-inducing Hungatella hatheway in progressive patients. Takewaki Poster 125. #ACTRIMS @actrims

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Barry Singer MD 🧠

@drbarrysinger

4 years

Covering my hospital for Neurology this weekend, but @SKriegerMD is the real hero: redeployed from #MS doc to #COVID19 doc in NYC. He’s my latest PODCAST🎙Guest on #Telemedicine @MustStopMS @CathyChes @TheGirlWithMS @PositiveWithMS @nclark140 #MSCOVID19

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Barry Singer MD 🧠

@drbarrysinger

2 years

Lassmann: Central vein sign and iron rims are found in #MS but not #MOGAD . Perivascular infiltrates in MS are CD8+ T cells and B cells while CD4+ in MOGAD patients. #ean2018 @EANeurology @TheSumairaFDN @TheMOGProject

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Barry Singer MD 🧠

@drbarrysinger

6 months

#Ultomiris (ravulizumab-cwvz) just approved in the US for the treatment of adults with neuromyelitis optica spectrum disorder #NMOSD . ZERO relapses in 58 NMOSD patients over median 73 weeks on every 8 week infusions. @TheSumairaFDN @guthyjacksonfdn @AaronBosterMD @Brandon_Beaber

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Barry Singer MD 🧠

@drbarrysinger

4 years

#Ponvory #ponesimod FDA approved! Oral S1P1 medication. Decreased relapses 31% & new MRI lesions 56% compared to Aubagio. Read more: @AaronBosterMD @Brandon_Beaber @RanyAburashed @CathyChes @MustStopMS @TheGirlWithMS @sumadshah @DrJim4MS @MSViewsandNews

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Barry Singer MD 🧠

@drbarrysinger

2 years

Jacobson @NIH reveals trials clinical trials for #MS that tackle 🦠 viral trigger. Focus on #EBV Epstein-Barr #virus . 🗝️❓Is #MS prevention and disease reduction possible with an anti-viral approach? #ACTRIMS2023 #ACTRIMSForum @neurology_live @C_OrejaGuevara @GavinGiovannoni

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Barry Singer MD 🧠

@drbarrysinger

2 years

Best #MS shirt of the week. @MustStopMS @themsguide @AaronBosterMD @Brandon_Beaber

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Barry Singer MD 🧠

@drbarrysinger

3 years

Antiviral therapy for #MS ? Treat chronic B cell infection with #EBV Epstein-Barr Virus. HIV-positive patients on antiviral meds less likely to get #MS . Harvard experts weigh in: 🍎 @MustStopMS @nikosevangelou3 @IntNatlWiMS @DrJim4MS

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Barry Singer MD 🧠

@drbarrysinger

5 years

#Zeposia #ozanimod just @US_FDA approved for relapsing forms of multiple sclerosis #MS . A S1P modulator that does not require first dose observation. Superior to Avonex on relapses and MRI activity including preserving brain volume. Read more: @MustStopMS

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Barry Singer MD 🧠

@drbarrysinger

14 days

Frexalimab 2 extension data up to 72 weeks demonstrates robust impact on enhancing lesions and relapses with favorable safety profile. @GavinGiovannoni presented #ECTRIMS2024

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Barry Singer MD 🧠

@drbarrysinger

4 years

#MSVirtual2020 has been a positive experience but looking forward to catching up in person at ⁦ @ectrimscongress ⁩ in Vienna Oct 13-15, 2021. #NeedVaccine ⁦ @C_OrejaGuevara ⁩ ⁦ @J_SastreGarriga ⁩ ⁦ @KlausSchmierer ⁩ ⁦ @GavinGiovannoni ⁩ ⁦ @bart_professor ⁩

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Barry Singer MD 🧠

@drbarrysinger

5 years

Happy Holidays from all of us at The MS Center for Innovations in Care ⁦ @MissouriBaptist ⁩. May you have a joyous holiday season and a good 2020! Thanks to all our #MS patients that have trusted us with their care!

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Barry Singer MD 🧠

@drbarrysinger

1 year

Marrie: Depression and anxiety in the top 5 of medical conditions that affect people with #MS . Anxiety can be associated with more relapses. Depression has been associated with worse disability. #MSMilan2023

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Barry Singer MD 🧠

@drbarrysinger

2 years

Just published: Phase 3 ULTIMATE I & II trial results #ublituximab vs teriflunomide #Aubagio . On ublituximab, 49-59% reduction of relapses & 94-97% reduction of contrast-enhancing lesions. @KlausSchmierer @C_OrejaGuevara @Brandon_Beaber @AaronBosterMD

Ublituximab versus Teriflunomide in Relapsing Multiple Sclerosis | NEJM

The monoclonal antibody ublituximab enhances antibody-dependent cellular cytolysis and produces B-cell depletion. Ublituximab is being evaluated for the treatment of relapsing multiple sclerosis. I...

www.nejm.org

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Barry Singer MD 🧠

@drbarrysinger

5 years

Had fun chairing Walk MS yesterday in St. Louis with Team MoBap despite the cold, rain and wind! Glad to see all the resilient supporters of those living with #MS @gatewayms @mssociety @MissouriBaptist

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