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Andrew Sparling Profile
Andrew Sparling

@awsparling

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Ph.D., history. History of science & medicine; Paracelsus; c16 Germany. Husband & father. Same handle on Bluesky, Spoutible, & Mastodon—esp. Bluesky.

Victoria, Australia
Joined August 2021
Don't wanna be here? Send us removal request.
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@awsparling
Andrew Sparling
11 days
Reminder: every fresh Twitter exodus leaves the site more toxic.
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@awsparling
Andrew Sparling
2 years
Just a reminder: Here's what the CDC's community transmission levels are currently said to be, despite low testing.
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@awsparling
Andrew Sparling
2 years
Just got my 4th shot at CVS. No staff masking. The woman who gave the shot put on a surgical mask *after* bringing over the immunization kit. Seven feet away, a woman was requesting free COVID tests “because my husband is unwell; I think he has COVID.” She, at least, was masked!
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@awsparling
Andrew Sparling
1 year
Osterholm: "we're actually seeing a population that, in many cases, is becoming less immune, not more. Because as time goes on, we know that the duration of protection from both vaccine and previous infection wanes." Also a practical lesson: don't unmask in elevators.
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@awsparling
Andrew Sparling
2 months
A very important paper is out in Nature on the role of pathological coagulation in Long COVID. Spike protein causes thromboinflamation by binding to fibrinogen, the soluble blood protein that converts to fibrin, the central component of blood clots. That inflammation in turn
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@awsparling
Andrew Sparling
3 years
Ugggh. 40 hr ago we had to take our younger kid to the ER at Hasbro Children’s to get a lacerated eyebrow glued shut. 3 hr in the waiting area, crowded, dubious ventilation. My wife wore her Envo Mask but the little one isn’t great at masking yet. 3 hr ago he started vomiting.
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@awsparling
Andrew Sparling
3 years
@jklmd123 Hilarious, isn't it, that the powers that be are vaunting everyone's personal freedom to make decisions, while depriving us of the information that we would need to exercise such freedom.
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@awsparling
Andrew Sparling
3 years
Very interesting. The Omicron variant has been known for less than 2 months and in South Africa there are already people getting *reinfected* with it. It *may* turn out that pursuing herd immunity through mass infection with an immune-evasive virus that attacks the immune system
@MelpomeneMel
Melpomene
3 years
And there it is... I knew this was going to be a thing. You CAN get Omicron twice. Reinfections are already happening
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@awsparling
Andrew Sparling
5 months
SARS1 caused vascular necrosis of the femoral head years later. Infants now recently starting to experience hip pain and limping. Watch the intel from the front lines, as @brownecfm reminds us!
@Abster_1983
Abster
5 months
More infants attending x-ray for hip pain and limping, last few days. All recent "cold symptoms", along with rest of family. X-rays normal. Wondering whether "cold" is Covid and remembering the paper on 20yr follow-ups in SARS-CoV-1; one of the sequelae was femoral head AVN.
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@awsparling
Andrew Sparling
2 years
@JessGrose A 9/11’s worth of deaths every *week* since July from COVID in the U.S.; a Twin Tower’s worth yesterday alone, yet people are acting as if nothing were happening. And almost every one of those deaths would be preventable if everyone slapped on an N95 and wore it properly for a
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Andrew Sparling
2 years
6yo home from day camp. He reports, “People don’t know what my mask is.” Although most of the camp is outside, he wears his Flo Mask indoors. One kid apparently thought that he was missing part of his face. I suggested that he tell them he’ll from another planet & can’t breathe
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@awsparling
Andrew Sparling
2 years
I’ll wait out my 15 min. in my car, thanks
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@awsparling
Andrew Sparling
10 months
So long, 2023. So long, NOVID.
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@awsparling
Andrew Sparling
2 months
causes not only blood-vessel damage but also neuronal damage, including the death of brain cells. Therapies targeting fibrinogen and microclots, such as nattokinase, should be very useful!
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@awsparling
Andrew Sparling
3 years
@merry123459 @albertabella17 When masks come off in indoor spaces, anecdotal reports show that Omicron approaches a 100% attack rate, regardless of vax status. That means 1 person can infect everyone in the room, if the LFT doesn’t detect them. This happened to all 10 at a dinner party in London last wk.
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Andrew Sparling
3 years
@Captaincoby00 Of course. For the same reason I wear one when removing drywall: to avoid breathing in crap that may ruin my health. It's not a difficult calculation.
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Andrew Sparling
3 years
@watermelonpunch @farid__jalali @alexmeshkin Maybe 3/4 of people? Maybe more? It’s hard to see from our Twitter feeds, but outside them it’s… like the Dark Ages.
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Andrew Sparling
1 year
Wow. Just wow. The Surgeon General's pathetic substitute for public health, the "war on loneliness," is starting to look like a coordinated absurdist exercise, "post-pandemic":
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@awsparling
Andrew Sparling
3 years
is a spectactularly stupid idea.
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@awsparling
Andrew Sparling
10 months
Jha tries to split hairs by telling people that immune *dysregulation* is somehow not immune *damage*. But the assertion is nonsensical. The immune system is a *system*. To dysregulate a system is to knock it out of kilter. When that occurs, the system is by definition damaged.
@ashishkjha
Ashish K. Jha, MD, MPH
10 months
There's a lot of bad information out there about how covid damages the immune system It really doesn’t But you know what does? Measles And thanks to the antivaxers We are seeing measles outbreaks again Encourage people to get their kids vaccinated It’s really important
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Andrew Sparling
1 month
@thecovidslayer Ugh. I'm sorry. I can't fathom this mindset. It's like, the zombies are still surrounding the house, but I'm bored, and we've been here all night, I wanna go to 7-Eleven.
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@awsparling
Andrew Sparling
3 years
keep those N95s on and that Levoit blastin’.
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@awsparling
Andrew Sparling
2 years
@JessGrose fortnight. The feeling you aren’t giving a name to is the shame at the cowardice of mass capitulation and the fear of the mass harm that’s impending from the long-term effects of repeated infection. Especially the gratuitous injury to children.
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Andrew Sparling
3 months
@ravenscimaven @K8te_k8te_k8te Snack around and find out
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@awsparling
Andrew Sparling
3 years
Under the weather
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Andrew Sparling
3 years
Dx: concussion/brain injury highly unlikely (patient is alert, unimpaired; nay, chirpy); GI virus highly likely; COVID possible (GI symptoms with Omicron relatively common in pediatric patients). Rx: antinauseant, wipe down surfaces but don’t waste your time with hand sanitizer;
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Andrew Sparling
3 years
@annect64 @NjbBari3 Brain infiltration, damage to the olfactory bulb, cognitive decline, erosion of gray matter, murdered astrocytes, damage to the cerebellum causing dysautonomia, proliferation of Lewy bodies, spongiform encephalopathy possibly leading to prion disease, please pass the cranberries
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Andrew Sparling
5 months
@1goodtern I allow some agnosticism by saying it’s either COVID or something you’ve caught because COVID has trashed your immune system. (I’m very popular at parties.)
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Andrew Sparling
1 year
@masksplaining I try to carry a few 3M Auras (N95s) with me. I haven't yet had the opportunity to give one to someone in a doctor's office.
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Andrew Sparling
4 months
We know that COVID must be hitting the American NE hard now, because the Human Yankee Candle Index, @ashishkjha , has started tweeting again that the pandemic is over, that COVID is no big deal, and that the increasingly irrelevant annual vaccines are the antidote to all worries.
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Andrew Sparling
1 year
@BaileyDevine20 Unremediated lead paint. This is the clearest parallel to the level of societal harm that we’re talking about. Mass harm to children in cities across the U.S., barely addressed, and allowed to continue for decades.
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Andrew Sparling
3 years
@amethystarlight @jklmd123 *You* are an American hero. This is monumentally important work.
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Andrew Sparling
3 years
@boggleknits Yeah, Noro remains a strong possibility. Because of the head injury he’s back in the ER now, at the advice of the general practice, on a Friday night; if it’s Noro we have no easy way of preventing him from infecting others. Emergency departments are poorly thought out.
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Andrew Sparling
2 years
@alexgdodds Yah, a lot of people are acting like just cuz you can apparently catch it via anal sex, you can only catch it by anal sex. It has all the makings, so far as I can tell, of a perfect day-care plague. I’ve *had* hand-foot-mouth, complete with rash, as an adult. Caught it from
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Andrew Sparling
2 years
I should add that this pharmacy *does* have a drive-through (or “drive-thru” if you will).
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Andrew Sparling
1 year
@MLS_Dave Buried near the bottom of the piece: “Makenzie Boyle, a 28-year-old human resources administrator in San Francisco, went to the emergency room when she was infected with Covid for the first time in December 2020 and was diagnosed with pneumonia. A year later, Boyle was diagnosed
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Andrew Sparling
2 years
@dshoskes @UnitedAirlines Their Twitter handle is apparently now @United . If they aren’t going to take passenger safety seriously by at least strongly encouraging good masks, I’ll not fly with them.
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Andrew Sparling
2 months
For a visceral understanding of the significance of the paper, skip straight to Fig. 1f, which "Human plasma" vs "Human plasma + spike." Not many micrographs actually make me queasy, but this one does.
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Andrew Sparling
3 years
@myrabatchelder Look, most of the country is ignoring BA.1, and it's currently filling the hospitals and spreading through the schools. Who's anticipating and preparing for the next wave 3–4 wk out? Not my neighborhood.
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Andrew Sparling
2 years
@EdmontonThug I was on my own, so as a courtesy I phoned them, navigated their tedious phone tree, & advised them that I was still alive before driving off. The woman had voiced concern that I might pass out in my car—which is *much* less likely than catching B2.12.1 in the waiting area.
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@awsparling
Andrew Sparling
2 months
Ryu et al., "Fibrin Drives Thromboinflammation & Neuropathology in COVID-19," Nature 2024 (pub. online 28 Aug).
@AkassoglouLab
Katerina Akassoglou
2 months
Our new paper is out @Nature We report that fibrin drives toxic inflammation, impaired viral clearance & neuropathology in #SARSCoV2 infection treated by #fibrin antibody #LongCovid #Coagulation #Immunotherapy #fibrinogen #COVID19
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Andrew Sparling
1 month
@michael_hoerger We’re in the Bad Place, aren’t we.
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@awsparling
Andrew Sparling
3 years
@greg_travis @zerocovid4kids I dunno—I’d sure be tempted to leave them a pile of recent journal articles from Science, Nature, JAMA, the Lancet, and NEJM, with a condescending note about the need for physicians to educate themselves continuously… AND the cake. But admittedly it’s more work to go that route.
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Andrew Sparling
3 months
@KellyScaletta @thrive_win you are lucky, they may improve with time. Finally, at all costs avoid catching COVID again. Wear an N95 in indoor public spaces. We may have a sterilizing intranasal vaccine within a year.
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Andrew Sparling
3 years
I have not reviewed in detail Alberta's Rapid Evidence Report on PPE, dated 13 Sept., but I have a few impressions to share. They are informed by my training in the history & sociology of science & medicine, as well as my undergrad background in phil at U of Calgary. @CPita3 /2
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Andrew Sparling
1 year
@MLS_Dave Repeated infections are generally mild, but they exact a “psychological” toll. The pieces of this narrative don’t quite line up, do they? Maybe that’s why the author is called the “breaking health” reporter. Too many people have already had their health broken.
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Andrew Sparling
2 years
@vbagate Speaking as an historian of medicine & a parent: Everyone ought to be very worried. The only reasons people aren’t are fatigue, incomprehension, & failure of imagination. Just think, e.g., how well daycares are prepared to interdict MPX from spreading via changing tables.
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Andrew Sparling
1 year
@MLS_Dave “with diabetes, which her doctor said was an effect of Covid — research has shown a link between the two conditions. “Boyle’s third infection, though mild, exacerbated lingering symptoms from her first illness, such as fatigue and swelling in her extremities. Then after her fifth
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Andrew Sparling
1 year
@MLS_Dave “infection in June, she developed chronic kidney disease and chest pain that hasn’t gone away, she said. (Studies have indicated that Covid can directly infect kidney cells, and consequently contribute to kidney disease.)” So the premise of the article remains,
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Andrew Sparling
2 years
I would like to second this, but in all caps: WHEN A WEIRD NEW HEALTH ISSUE ARISES GLOBALLY AFTER THE WEST'S COORDINATED DECISION TO ALLOW MASS INFECTION OF THEIR COUNTRIES' POPULATIONS WITH A NOVEL, EXTREMELY PATHOGENIC VIRUS, IT'S THE HEIGHT OF INTELLECTUAL DISHONESTY /2
@lisa_iannattone
Dr. Lisa Iannattone
2 years
When a weird new health issue arises globally after the West’s coordinated decision to allow mass infection of their countries’ populations with a novel, extremely pathogenic virus, it’s the height of intellectual dishonesty not to consider that novel virus as the prime suspect.
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Andrew Sparling
1 year
Well, *that* can’t be good … #Aranet4
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Andrew Sparling
2 years
@jrisherWalks The link to it directly is useless because it bounces you to the greenwashed map. From the top of its page, you have to choose the link to “community transmission levels.”
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Andrew Sparling
2 months
A great explainer From Satoshi Akima here, as well as a link to his explainer on the preprint:
@ToshiAkima
Dr Satoshi Akima FRACP 『秋間聰』
2 months
The paper is now out in @Nature after I tweeted on this oral presentation @ISTH 2023 by @AkassoglouLab . Fibrin/fibrinogen may be a therapeutic target in СОVΙD neuropathology. Link in next tweet.
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Andrew Sparling
2 years
@TheRMH Great to see a whole roomful of newly trained healthcare workers who know what kind of mask to wear during an airborne pandemic! This savvy behavior will inspire confidence from patients.
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@awsparling
Andrew Sparling
2 years
Alaska's all red too; it wasn't fitting in my browser's view window.
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Andrew Sparling
2 years
Earth’s atmosphere. He thinks that’s a good line to use.
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Andrew Sparling
3 years
In short, #COVIDisAirborne . AND (this is still part of the scandal) we possess simple, easily available technologies for preventing SARS2's inhalation: masks that stop aerosols, including N95s and up. /5
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Andrew Sparling
3 years
@DaniellaCarlisi Not planning to do any flying anytime soon, but I would be tempted to give the 50-min. ans., with copious bibliography from medical and scientific journals.
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Andrew Sparling
1 year
As I commented the other day: the fix was in early on. The goal was to rebrand SARS-CoV2 as novel rather than inherently pathogenic.
@ariccio
Alexander Riccio (@co2trackers)
1 year
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Andrew Sparling
5 months
@YouAreLobbyLud Hey, as it happens, so am I!
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Andrew Sparling
5 months
@crimsonartist I’m not anxious about COVID, but I’m a little apprehensive about dealing with nincompoops.
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Andrew Sparling
3 years
@DaniellaCarlisi I have no compunction about carrying a dozen or so articles in my carry-on, to slap down for punctuation, on my neighbor's tray table. I'd stick to NEJM, JAMA, the Lancet, Nature & its spinoffs, & Science, and maybe that piece from Annals of Internal Med., I think it was, on ...
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Andrew Sparling
2 years
@naytodazee I’m guessing that you’re just better informed than they are and maybe just a bit more courageous when it comes to facing up to reality.
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Andrew Sparling
2 years
@MelpomeneMel Wow. I sure hope you’re wrong! Better take pictures & document whatever it is as best you can. What does your state department of health tell you? Maybe notify the Airbnb guests and see if *they*’re eligible? @alexmeshkin , do your have anything to suggest about her getting tested?
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Andrew Sparling
3 years
In a nutshell, the scandal is this: scientists and physicians have known for decades that pathogens can travel as aerosols, not droplets; have known since 2006 that SARS1 did so; & have had solid case-based evidence of such transmission for SARS2 since at least Mar 2020. /4
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Andrew Sparling
7 months
@PHealthGnome I am not aware of any evidence that COVID aerosols behave differently from measles aerosols. Is there any? And what’s the theoretical basis for this claim? Argument from authority will not suffice here.
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Andrew Sparling
3 months
@KellyScaletta @thrive_win Search on here for nicotine & LC or long COVID & you’ll find a ton of comments—appears to help for some but not others. Meanwhile get detailed blood work if you can. Look for lymphopenia & specific wbc counts that are out of whack. Also check thyroid & iron metabolism (ferritin
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Andrew Sparling
3 years
@TheAmirImani Also, wearing coats is causing terrible psychological harm to children. There is no real research to support this, but it’s really really a serious problem.
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@awsparling
Andrew Sparling
1 year
With few exceptions , Ontario officials at every level have fought tooth and nail to resist mitigations against COVID & other airborne pathogens in hospitals & schools. Meanwhile, though, a quick Aranet4 reading is all you need to show that the provincial legislature is taking
@ONSchoolSafety
Ontario School Safety
1 year
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@awsparling
Andrew Sparling
2 years
@TRyanGregory For me it was horrible. I was assailed by venomous antimaskers calling me a demon and child abuser because I replied to someone that my kids wear masks to protect them from the brain-eating, immune-suppressing, organ-trashing bat virus. I've taken my account private.
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Andrew Sparling
3 years
@medexit @fitterhappierAJ No; it wouldn’t. It’s too late for that, if that would ever have been possible. We need as much vaccination as possible, high-quality masking, first-rate ventilation, rapid testing, contact tracing, isolation protocols, the whole 9 yards. With O the vaxxes will leak like crazy.
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Andrew Sparling
3 years
@CamNichelle @AlexanderDent6 Your “top doctors” are not the buffoons speaking for the provincial government; they’re the docs in the trenches & the ones fighting the official disinfo, eugenics, & droplet idiocy. Your real top docs advocate for respirators, airborne mitigations, & testing. And safe schools.
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Andrew Sparling
4 months
@clipartbug Personally I would cancel and reschedule elsewhere and explain why in writing. Not sure whether it would help in your case, but you might consider a cancer screening by poop-by-mail or whatever it’s officially called.
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Andrew Sparling
3 years
There's lots of questionable material coming out of this acct but here's 1 tweet that I'm finding hard to tolerate and may be giving me a rash. 2009 study with n=27. Concl.: "new respirator designs may be necessary to improve tolerability." Such designs are now available! 1/
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Andrew Sparling
3 months
@Timodc @mattplotner Except that these “fans” are people who read science & medical journals, pay attention to the constraints of physical reality, & have the gumption to realize that an airborne vascular disease that trashes immune systems & brains can be easily interdicted by physics. Step aside.
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Andrew Sparling
3 years
@NateSilver538 A jaw-droppingling specious argument. The chief way to restrict the spread of SARS-CoV2 is to reduce the number of superspreader events. Airplanes can be sites of such events, & when they are, they seed the virus far & wide. N95s or better curtail such transmission chains.
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Andrew Sparling
2 years
@AgelessObserver @sameo416 Cape Cod & want to know the risks of a shark attack, you’d look at rates of shark sightings & attacks, not how many intensive-care beds were available. The fact that the highest level on the green map is terra cotta should also be a tip that the goal is to hoodwink, not inform.
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Andrew Sparling
4 months
@notnaughtknot @4d3d3d3d3 My son, at 2, saw my PhD adviser’s car, before the boy could name colors. He only saw the car once, but recalled correctly, several months later, that the car was red. (I do not believe tat the color of the car had ever been a subject of conversation.)
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Andrew Sparling
10 months
The 3yo was the weak link. His masking game leaves quite a bit to be desired. Looks like all 4 of us have got it now. The 7yo just gave an ambiguous result, followed immediately by a negative, but he’s symptomatic and we don’t believe he’s not got the virus.
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Andrew Sparling
2 years
@kelcsimpkins And it’s bloody typical of the healthcare response that the patient is wearing an Aura and the HCW is wearing a surgical mask over a beard.
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Andrew Sparling
3 months
@KellyScaletta @thrive_win & transferrin). COVID can lead to autoimmune hypothyroidism (where your immune system trashes the thyroid gland). Look at CD4/CD8 ratios. They can be way off, even while the total of all white blood cells is OK. And rest assured much as you can!! Chart your symptoms. If
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Andrew Sparling
1 year
@Sbharris11 Nope. It doesn't. Boosters largely wane by 90 days, and the only ones available so far have included the extinct Wuhan strain. Some studies are showing *negative* efficacy against recent variants, because of immune imprinting (original antigenic sin).
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Andrew Sparling
2 years
@bridget857 @HelenBranswell Not so unknown anymore. The literature is accumulating at a rate that, for scientific literature, is breathtaking. Forget about the acute illness, which has a relatively small chance of killing you immediately. The medium-term damage is just a train-wreck. I'd rather put off
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Andrew Sparling
3 months
@arijitchakrav @WHO @CDCgov Nice use of the brown highlighter
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@awsparling
Andrew Sparling
3 months
@BathroomReports Anyone can search PubMed on the Internet, too
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Andrew Sparling
3 years
But the professional community known as IPAC (Infection Prevention and Control) has been sl-o-o-o--o-w to accept these realities. The AB report, while not denying the reality of airborne transmission, claims the evidence remains insufficient to warrant adopting N95s widely. /6
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Andrew Sparling
6 months
@DrTedros @WHO @AfricaCDC Years of denial, culminating in fresh obfuscations. Yet COVID remains airborne! It’s simple and easy to understand: #COVIDIsAirborne ! You’re drumming yourselves out of the scientific community with your folderol.
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Andrew Sparling
3 years
@KatePri14608408 Sorry to hear that this happened. I would strongly suspect the restrooms/outhouses as likely sites of transmission. COVID aerosols will hang in the air, potentially for hours, especially in confined spaces. "Outdoor" events have to have toilets, and the toilets always have doors.
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Andrew Sparling
3 years
@Laurie_Garrett What else would you expect? Omicron’s speed at infecting people has little or nothing to do with how quickly it kills them. The question is, is it killing them in the same ways? Perhaps it spreads quickly but kills more slowly than other variants. We have no way of knowing yet.
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Andrew Sparling
3 months
@1goodtern Is there any documented case of anyone catching COVID by touching *anything*? (cc: @jmcrookston )
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Andrew Sparling
3 years
@AlisaValdesRod1 in understanding the disease course. And it holds out the tantalizing possibility that indeed Paxlovid might be a game-changer for you—& others. You need a research-minded doc who will say to him/herself, “Hey, I might be able to help this person *&* get an article out of it.”
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Andrew Sparling
2 years
@alexgdodds my kid, who caught it daycare. It didn’t exist in North America when I was a child. What’s to stop MPX from following suit??
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Andrew Sparling
2 years
@danaparish It’s reasonable to suspect post-acute COVID sequelaein these cases, especially since Ontario has been retrograde about N95 use, but it must be remembered that Toronto physicians, like those elsewhere, have been subjected to enormous workplace stress in the last three years also.
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Andrew Sparling
3 years
How do people catch the delta variant? According to the experts in a Sept. 14 UBC Webinar, contamination happens when people "let down their guard" and "pick their noses." Nosepicking is going on at a ferocious "15-25x/hour"!). Yup, we know this happens because "there is data."
@GreaterfoolVan
r/Coronavirus_BC
3 years
N95 for in-office (clinic) settings? "No, you do not need an N95 respirator for the Delta variant". ... "average person picks their nose 15-25x/hour"
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Andrew Sparling
2 months
Corresponding authors on the Fibrin & SARS-CoV2 Spike paper are Warner C. Greene & @AkassoglouLab ; the two leads and others listed & tagged here:
@AkassoglouLab
Katerina Akassoglou
2 months
Study led by @JaeKyuRyu @yan_zhaoqi Mauricio Montano, Elif Sozmen, Karuna Dixit, Rahul Suryawanshi In collaboration w/ the labs of Warner Greene @TheOttLab @DoctorBou @kristyredhorse @xanderpico @KroganLab Mark Ellisman @GladstoneInst @UCSF @UCLA @UCSanDiego @Stanford @QBI_UCSF
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@awsparling
Andrew Sparling
20 days
@Obnoxiouss01 @OliverJia1014 Cigarettes & alcohol only. Housing is expensive in Japan. Most were middle-aged men, living orderly lives, to all appearances. This was in the mid-90s.
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@awsparling
Andrew Sparling
2 years
@Asta_de_B @DFisman I think my answer to that belligerent question is now going to be, “No, I plan to take it off periodically to bathe.”
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Andrew Sparling
5 months
I'm getting the distinct impression that the viral shit is hitting the fan right now in Melbourne-area schools. When to throw the circuit breaker and pull the kiddo for a couple weeks??
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@awsparling
Andrew Sparling
3 years
Thomas Kuhn and others have observed that scientific paradigms don't usually flip because individuals experience epiphanies, but because the old guard dies off. But we've got to keep trying to persuade, because the current emergency can't wait that long. /39
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Andrew Sparling
6 months
@OurShallowState I think he ate someone that didn't agree with him.
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