Thrilled that I will be starting as an Assistant Investigator at
@MGHMedicine
and Assistant Professor (after HMS approval) at
@harvardmed
this September : )
I will continue to work on multi-omic dissection of disease causes & mechanisms, particularly somatic-germline interplay.
Our review article is out!🎉
Grateful for the chance
@NatureRevGenet
@pnatarajanmd
to delve into the similarities, differences, and interplay between somatic and germline mutations🧬with super talented
@TimCoorens
!
Also, thank
@haertl17
for the dedication in handling the review!
Each year, STAT pores over hundreds of nominations in search for the next scientific superstars. We caught up with five members of the 2023 class of STAT Wunderkinds.
Our new preprint "Human Plasma Proteomic Profile of Clonal Hematopoiesis" is out🎉! Mentored by
@pnatarajanmd
@Dr_RajatGupta
, we leveraged paired DNA & proteomics data from ~62K humans and new scRNA-seq data from mice to uniquely characterize the proteomic landscape of CHIP🧬
Is the spleen, a hematopoietic organ, involved in coronary artery disease❤️?
Our new study, led by Meghana & co-supervised with
@pnatarajanmd
, used deep learning to reveal non-invasive insights into spleen pathologies and their shared🧬basis with CAD.
#AHA22
I will be presenting our work linking clonal hematopoiesis, plasma proteome, and coronary artery disease at tomorrow's Inflammatory Mechanisms of Cardiac Disease session.
Time & location: Nov 7 (Monday) 9:30am-10:30am, S102A
Please stop by if interested : )
@deniswirtz
Yes. And my advisors helped me a lot by recommending me as an ad hoc reviewer for articles and connecting me with outside researchers to provide independent references, which were also required for green card application : )
Had a great time presenting our work and meeting old & new friends at BIG Chinese Academy of Sciences (China National Center for Bioinformation), National Center for Cardiovascular Diseases, and Hong Kong BU : ) Many thanks to
@wallacemwang
&
@BennyCho8
for hosting/coordinating!
Another piece of the aim 1 of my PhD thesis is on AJKD😃 Here, we rigorously examined the associations between risk factor, obesity measured in various ways, and prospective kidney function decline and ESKD. This laid the foundation for our follow-up studies addressing causation.
With aging, people get CHIP which increases many diseases risks. While we cannot reverse aging, we can explore modifying CHIP-associated CVD risk via somatic-germline interactions. Many thanks to many people, particularly fantastic mentor
@pnatarajanmd
and friend
@Yunfeng_Ruan
🤗
Our preprint led by
@ZhiYu_ACGT
uses germline genomics, somatic genomics, and transcriptomics to dissect inflammatory mechanisms of clonal hematopoiesis-associated CVD with in vitro validation
@medrxivpreprint
[1/12]
Inspired by the high rate of comorbidity between CAD and respiratory infections, we did a genome-wide pleiotropy scan and identified their shared genetic immune axes. Many thanks to superstar mentor
@pnatarajanmd
and brilliant colleagues
@bryanmac14
@zekavatm
@rachelbernardo_
😃💃
Pneumonia and CAD are co-morbid conditions providing an opportunity to examine shared mechanisms.
In our study led by
@ZhiYu_ACGT
, we performed a genome-wide pleiotropy scan to examine immunologic mechanisms for CAD.
@ScienceAdvances
[1/3]
We associated CHIP with the plasma proteome measured by SomaScan in TOPMed, validated our discoveries with cross-species (mice) and cross-platform (Olink) approaches, and integrated CHIP-proteomics with disease contexts with pinpointing proteins associated with both CHIP & CAD
#KidneyWk
Excited that our
@JASN_News
paper linking polygenic risk of eGFR decline to kidney diseases and ~5K circulating proteins has been selected to be presented at this year's “Best of
@ASNKidney
Journals” session. Please join us on Friday November 5 5-7PM ET if interested :)
Kidney Week 2021 is just around the corner. Have you read the articles featured in the Best of ASN Journals session yet?
It's not too late! All articles in this year's session are freely available during Kidney Week. Explore the collection here:
#jnlcoll
Inspired by the CANTOS trial and leveraging the PLACO methods
@DrDebashreeRay
@nilanjan10c
, we conducted a genome-wide pleiotropy analysis and identified the genetic immune-inflammatory axes of CAD linked to respiratory infections implicate ADAMTS7 and IL6R, and related genes🧬😃
CAD & pneumonia are comorbid conditions. We performed a genome-wide pleiotropy analysis of the two to better understand immune genetic pathways linked to CAD. Led by all-star
@broadinstitute
post-doc
@ZhiYu_ACGT
in collaboration w P. Libby & H. Finucane
#SuddenCardiacDeath
is devastating. Using
#MachineLearning
methods capable of handling time-dependent & static variables, we
@ScottZeger
1) developed a population-based approach for SCD risk stratification and 2) identified a single decision tree for making ML prediction apparent
Congratulations
@zhiyu42
! Zhi is the 2020 Delta Omega Scholarship Competition winner for the “Applied Research” category for her submission entitled “Integrating Multiple Omics Approaches and Human Biology for Understanding Kidney Function.”
Our work is on bioRxiv😊Using large studies for discovery, we constructed a genome-wide PRS for kidney function sufficiently strong to capture risk for a spectrum of incident kidney diseases and influence the circulating proteome measured 20 years apart.
Matthias & I discussed
@atlasmaths
and
@kirylukk
's recent work where they innovatively integrate monogenic (APOL1) and polygenic factors to form a genome-wide score highly predictive of CKD across ancestries. As we wrote, "we enjoyed reading this work": )
You've probably heard me rave about the phenomenal mentor, the talented colleagues, and the wealth of data and collaboration resources in our lab many times. If you're a human genetics researcher looking for a postdoc, highly recommend checking out this fantastic opportunity!
We know circulating hematopoietic cells influence CAD risk, but the role of a key regulating organ, the spleen, is unknown. We combined deep learning + predictive modeling + GWAS and gene prioritization to dissect the spleen-CAD link.
#AHA21
Excited to present our work examining the under-addressed immune-inflammatory axes of CAD through leveraging its genetic pleiotropy with pneumonia. Please tune in the "New Human Genetics Frontiers for Cardiovascular Disease❤️🧬" sessioin on Monday if interested😊
When our paper on the association between kidney function and BP was published, the editorial asked "Is It Causal?" Here is our answer😃: using Mendelian randomization, we identified causal effects of higher kidney function on lower BP.
@biorxiv_genetic
#Mynameis
Zhi, which means flowing water in the Classic of Poetry, the oldest collection of Chinese poetry. Together with my surname, Yu, they mean fish in water🐟🌊.
For the CAD-associated splenic radiomic features, we took it a step further by exploring their genetic basis through GWAS and gene prioritization, identifying 219 loci.
Among these loci, 35 are previously known CAD loci, hinting at a shared link between the spleen and CAD. Notably, the 9p21 locus - whose mechanism is still "elusive" despite its initial discovery in 2007 - is among them, suggesting the spleen may play a role in its CAD relevance.
Spleen is challenging to study due to its rarity in routine clinical assessments and often requires invasive methods. We used deep learning-based segmentation and radiomics to non-invasively extract 107 features from MRIs of UKB participants, capturing shape, size, and texture.
Yes, kidney function and blood pressure has been a classic associtiation in nephorology. What is chicken and what is egg, or both? This dedicated commentary nicely elaborated on how our bi-directional Mendelian randomization study addressed that question😀
@MGHMedicine
@harvardmed
@pnatarajanmd
@nilanjan10c
@JoeCoresh
@ScottZeger
Deeply grateful for the precious opportunities to connect with and learn from many very talented and kind scientists during my job search🙏- it was quite an eye-opening process of learning about their exciting work and also ambitious initiatives at institutional levels.
Very intelligent and personable Dr. Jin is looking for a postdoc at U Penn. Trained by legendary
@nilanjan10c
, she runs an exciting statistical/computational lab. Great people, great place, and a fantastic opportunity if you're into statistical genetics & predictive modeling : )
I'm looking to hire a postdoctoral fellow to work on projects in statistical genetics/genomics, causal inference and predictive modeling. Feel free to contact me by email! Job ad:
#postdoc
@UPennDBEI
@meg21212
@JHUWelchCenter
Thank you so much, Morgan, for your enormous help and support throughout these years, and for being our great role model! I feel so privileged to have you as my mentor😊.
@nilanjan10c
Many thanks
@nilanjan10c
! You are so instrumental in the entire process - starting from getting me into the genetic epi & stat gen field, mentoring several works, suggesting I do postdoc with
@pnatarajanmd
, and providing insights & suggestions for many important decisions : )