James 🥥🏈 Pirruccello @jpirruccello Twitter profile

Last Seen Profiles

@path2pub

@shaftag

@bokeplokalmalam

@konyagyamada

@BDesniar

@bokeplokalmalam

@cukienaknikmati

@charlie_lees

@StalkingVi96051

@RacerSonic

@Brumedemer

@MambaMexican

@Brigitte785

@xmannew3

@SteveKornacki

@RoPi_fortnite

@ma_looohStudios

@cchsbballsaints

@GuBertrand

@ChrisAuregan

@samatimemagari

@noppi_jeuf

@_CYCSC_

@soobphoria

@EdulioRojas

@eugeniadepina

@rsomchai1964

@bosmans21

@bendunk51

@Gojo909

@Hijabbacol2883

@lmhmdhsn509

@salakkam61

@john_mullican

@SchemersEnt

James 🥥🏈 Pirruccello

@jpirruccello

4 years

No physician has an unhealthy diet.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

@JoeBiden Why is the presidential seal blurred out?

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Why not.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Write notes. Not too long. Mostly plans.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Our analysis of right heart structure and function is now published in @NatureGenet . We used deep learning to measure the right atrium, the right ventricle, and the pulmonary root & artery in the @uk_biobank . Paper is here:

Genetic analysis of right heart structure and function in 40,000 people

Nature Genetics - Genome-wide analyses of cardiac magnetic resonance imaging data identify loci associated with right heart structure and function. A polygenic predictor of right ventricular...

www.nature.com

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Stoked to be joining friends like @CardioOncology and other @SarnoffCardio alums at UCSF starting this fall.

UCSF Cardiology

@UCSFCardiology

2 years

Welcome @jpirruccello ! Dr. Pirruccello joins @UCSF in Oct from Mass. General Hosp. He brings with him an impressive research program and @NIH funding in cardiovascular genetics and will help lead the cardiovascular cohort in 3D health @UCSF_BCHSI .

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Here, have another

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James 🥥🏈 Pirruccello

@jpirruccello

8 years

@deray @CNN When a lawmaker is making a false equivalence to your face:

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

As you can see, there is a growing interest in "stuff"

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

@briankrebs Selfies submitted to a nongovernment entity that has a domain controlled by Montenegro. H/T @bradfitz

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

Is exome sequencing the most powerful tool ever invented to reduce the risk of death?

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

The literature is becoming more regrettable.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Bigger aortas are more prone to tear, but are usually asymptomatic until then. So, it would be nice to know the size of one's ascending aorta. 📐Did we measure everyone's ascending aorta? No. But we did build a simple clinical estimator, published today:

Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals

This study aims to develop and validate a clinical score to estimate ascending aortic diameter.

jamanetwork.com

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Ladies and gentlemen: the Python ecosystem

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Rants: 1. AllOfUs should be accessible to non-Americans 2. UK Biobank should be accessible from centralized platforms that are not DNANexus

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Simple idea: When conducting rare-variant burden tests to discover associations between genes and continuous phenotypes, you can get better results by adjusting for a polygenic score for the same phenotype. A 🧵 👇

Adjusting for Common Variant Polygenic Scores Improves Yield in Rare Variant Association Analyses

With the emergence of large-scale sequencing data, methods for improving power in rare variant analyses (RVAT) are needed. Here, we show that adjusting for common variant polygenic scores improves...

www.biorxiv.org

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James 🥥🏈 Pirruccello

@jpirruccello

6 months

This sky bridge is gonna be lit

Mass General Brigham

@MassGenBrigham

6 months

At Mass General Brigham, we are coming together to enhance clinical care, research, and education for the patients and communities we serve. Now, we are taking the next transformative step in that journey, beginning a process to combine our academic medical center departments.

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James 🥥🏈 Pirruccello

@jpirruccello

4 months

Why is the @AllofUsResearch app using 86.8 gigabytes of storage on my phone?

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

@TheDailyShow

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James 🥥🏈 Pirruccello

@jpirruccello

12 days

@jgschraiber The way I use them: * genetics is the study of how genes influence traits and disease * genomics is the study of the genome itself

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

Excited to share work done with @KrishnaAragam , where we discovered common genetic variants associated with the structure and function of the heart. These common variants, found in healthy people, also influence risk for heart muscle diseases.

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James 🥥🏈 Pirruccello

@jpirruccello

1 year

Our study looking at genetics of ascending and descending thoracic aortic strain and distensibility in 40,000 @uk_biobank participants is now out in @JACCJournals (full article available via this link). Strain doesn’t just recapitulate diameter.

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James 🥥🏈 Pirruccello

@jpirruccello

22 days

Our ascending aortic diameter estimation model incorporating clinical factors and genetics is now out in #EHJ @ESC_Journals

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James 🥥🏈 Pirruccello

@jpirruccello

7 years

@JoeNBC The word is Nazi.

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James 🥥🏈 Pirruccello

@jpirruccello

1 year

We derived aortic valve measurements in ~50k UK Biobank participants. Even among healthy people, aortic valve function exists on a continuum, influencing risk of clinically significant aortic stenosis and heart failure. (Images reproduced by kind permission of the UK Biobank)

Shino Kany

@ShinoKany

1 year

Valvular heart disease is common across the globe. We have a good understanding when to treat disease such as severe aortic stenosis. But we know little about normal variation of valvular function and where disease begins. So we looked at the UK biobank.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

@marceelias 12 -> 24?

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

If you select an embryo to reduce risk of dilated cardiomyopathy, you will increase risk of hypertrophic cardiomyopathy.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

Brief walkthrough to give background on work with @JenHoCardiology , @patrick_ellinor & @steven_lubitz looking at genetic factors associated w/ variation in right heart structure & fxn. This is work in progress and feedback would be welcome! First, a methods-focused thread.

bioRxiv Genetics

@biorxiv_genetic

4 years

Genetic Analysis of Right Heart Structure and Function in 40,000 People #biorxiv_genetic

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

I don’t know who needs to hear this, but the woman sitting at the physician’s desk with the other physicians is a physician.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

@anish_koka Imagine thinking this thought. And then imagine typing this thought. And then imagine submitting it to the internet for all to see.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

My bad

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

One small typo for a grant. One giant suggestion for @broadinstitute I hope this "imagining platform" includes puppies, rainbows, and cotton candy.

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James 🥥🏈 Pirruccello

@jpirruccello

8 months

Methods sections should continue to be auto-plagiarized unless you changed your methods or found a superior way to describe them.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

@vnparikh Unhealthy food was outlawed in the 1960s.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

Medicine eats up your whole life and the payoff is that the President insults you.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

I claim, for money purposes, everyone's bank accounts.

Donald J. Trump

@realDonaldTrump

4 years

We have claimed, for Electoral Vote purposes, the Commonwealth of Pennsylvania (which won’t allow legal observers) the State of Georgia, and the State of North Carolina, each one of which has a BIG Trump lead. Additionally, we hereby claim the State of Michigan if, in fact,.....

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

@DrSarahAxelrath “Ahh, but since that time we have discovered fire and the wheel.”

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

What column did you get to before realizing a spreadsheet was not the solution for your problem?

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

This review aged well.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

@johnlimouze Lots of people who don’t practice medicine seem to be really enthusiastic about giving, to those of us who do, the ability to deny care to the unvaccinated. We don’t want this! I would like these people to pick a different venue for their political revenge fantasies.

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James 🥥🏈 Pirruccello

@jpirruccello

1 year

In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not convinced that it tells us anything about ACLY.

Mendelian Randomization Study of ACLY and Cardiovascular Disease | NEJM

ATP citrate lyase is an enzyme in the cholesterol–biosynthesis pathway upstream of 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR), the target of statins. Whether the genetic inhibition of ...

www.nejm.org

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

@rwyeh @EricSecemskyMD @HeartBobH Conclusions: 1. The entirety of the protective effect of the exome (and cardiac MRI) is attributable to immortal time bias from cardiac MRI recipients. 2. This can be completely controlled for by deleting your immortal time. 3. This must be accounted for in the UK Biobank.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

3. GWAS summary statistics from the Million Veterans Project shouldn’t require dbGAP access.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

OK

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

@justsaysinmice This is a great account. Worth noting that nobody calls lab mice "patients," so just reading the first... 4 paragraphs... would be extraordinarily misleading.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

The Massachusetts COVID dashboard doesn’t graph ICU admissions, but it does provide the raw data so you can plot it yourself. From today’s data release:

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

The wall facing the Chair’s office at @MGHHeartHealth

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

Updated LV genetics analysis: - Now in 36,000 people & peer reviewed - More loci, TWAS as a secondary prioritization tool at each locus - Stronger PRS effect on DCM (1.58x HR per SD) - Replication (as best we could) Available as an open-access pub at

James 🥥🏈 Pirruccello

@jpirruccello

5 years

Excited to share work done with @KrishnaAragam , where we discovered common genetic variants associated with the structure and function of the heart. These common variants, found in healthy people, also influence risk for heart muscle diseases.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Do people unironically think that coffee confers a 30% all-cause mortality reduction?

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

In this household, we celebrate grant rejections.

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James 🥥🏈 Pirruccello

@jpirruccello

5 months

Announcing our new GWAS of the number "π". Some highlights (🧵👇): 1. Numbers are not heritable(???) 2. We couldn't even finish writing down pi because it just kind of... kept going? (See our 400 page supplement for our best effort.) Stay tuned for our upcoming "𝝉" GWAS.

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

👀

Thousands of missing variants in the UK BioBank are recoverable by genome realignment

The UK Biobank is an unprecedented resource for human disease research. In March 2019, 49,997 exomes were made publicly available to investigators. Here we note that thousands of variant calls are...

www.biorxiv.org

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

Professor @UREssien begins @BrighamWomens Medicine Grand Rounds with the ongoing history of racism and eugenics in medicine. (And of course I have another meeting that starts at 12:15 but I'll catch you on the recording.)

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

Status: Updating Harvard-template CV for grant applications. Frustration level: High. Gratitude for my @MGHHeartHealth program director who is helping me with this minutiae: Much higher. Thank you, @ddefariayeh !

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

You vs the KM curve they told you not to worry about:

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

@cjstreed @APKithcartMDPhD @AmerMedicalAssn @DrAlethaMaybank Ahh yes, white men are famously not responsible for any racism or inequities.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

@Public_Citizen Not a great graphic - the choice of summary ($1.8M vs $750) minimizes the visual Impact.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

@dril AKA the @dril “ETERNAL” timeline order

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

Breathtakingly rapid development of effective vaccines. Dramatically rising COVID case count driven by politics and structural inequity. A self-encapsulated study of how the US spends the most on healthcare and develops great therapies, but has poor health outcomes.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Work led by @mghmedres star @MahanNekoui studying genetics of aortic diameter, marching from root to arch:

Mahan Nekoui

@MahanNekoui

2 years

What genetics drive the diameters of the LVOT, aortic root, and ascending aorta? And how do these genetics influence disease? Excited to share our work in @JACCJournals with @jpirruccello @patrick_ellinor @mlindsay & others below

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Congrats to @mghmedres @MahanNekoui , who trained his own deep learning models to expand our understanding of the ascending aorta from root to arch. Mentored by @MGHHeartHealth @patrick_ellinor @MarkELindsay @broadinstitute

UK Biobank

@uk_biobank

2 years

Congratulations @MahanNekoui , Massachusetts General Hospital and Broad Institute, on winning our Early Career Researcher 2022 competition! Tune in to hear more about the fascinating research his team are doing using #UKBiobank data here: #ECR #UKBSC22

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

It has been a very tough decision for all of us on the Editorial Board, but today we are excited to announce our endorsement of @emilyswlau , @NinoNJ , @lflanflan , @aklfahed , and @DCrousillat for "Best Cardiology Fellow".

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

"We need more women cardiologists." - @DrQuinnCapers4 delivering a full-throated call to action with a data-driven @MGHHeartHealth grand rounds

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

If you write papers with more than one author, you should use AuthorArranger.

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James 🥥🏈 Pirruccello

@jpirruccello

1 year

Great to see @nauffal_victor ‘s work on mycardial fibrosis out today in @NatureGenet

Genetics of myocardial interstitial fibrosis in the human heart and association with disease

Nature Genetics - Genome-wide association analyses identify 11 loci associated with native myocardial T1 time, a marker of interstitial fibrosis, providing insights into the pathways involved in...

www.nature.com

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

@daniela_witten What a coincidence; I just got hired by twitter today. I am now in charge of the feature that adds lil crypto scam posts* below every famous person’s tweets. * = Send me one prime number and I’ll send you two back.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Everybody talks about Bonferroni but nobody talks about Malferroni.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

Imagine having representatives in Congress who understand infectious disease. It will be my delight to vote for @RobbieForChange this year.

peoniesrock

@Peoniesrock

4 years

Got my absentee ballot today! Vote for @RobbieForChange !

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James 🥥🏈 Pirruccello

@jpirruccello

4 months

@jeremyphoward I wrote to @Scott_Wiener (my state senator and the bill's author) encouraging him to abandon this misguided bill. It cannot help and it will do harm. We should regulate actions, whether those actions are informed by large models, small models, heuristics, coin flips, or whims.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

If physicians were involved in unwanted hysterectomies, which state boards licensed them?

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

Any reasonably led government would have sourced a sufficient supply of masks so that at this point - 6 months into a pandemic - hospital staff *and people in the community* could wear N95s whenever they wanted. #Masks4All

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

I worked with some unionized fellows this week in the UCSF CCU and they were extremely good at their jobs. xoxohth I will not be taking questions at this time

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Congrats to those of you who never have to go through a match process again.

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

One thing I like about living in BOS and working in Cambridge is the variable reward payout from riding the @MBTA Will there be trains every 2 minutes? Or every 20? The uncertainty and occasional big wins keep me coming back for more.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Just so grateful to @SarnoffCardio for the ongoing support.

Javid Moslehi

@CardioOncology

3 years

Wow!Talk about a power team! Sarnoff Scholar awardees! @baik_alan @jpirruccello @HanZhuMD #Arun @VirginiaSHahnMD @dkassjhu @ishahjain @saptarsi_haldar @skathire @SarnoffCardio @AaronAdayMD @josephahill @sday_hcm @pnatarajanmd @DrRosanneRouf @SeanM_Wu @IntMedAbel @JenHoCardiology

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James 🥥🏈 Pirruccello

@jpirruccello

7 years

@elissawashuta @deevybee

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

At least 3 times during fellowship people (not at MGH) confused me and @kparuchuri (presumably because we have unusual last names that start with 'P'). Now we are giving them a reason. H/t @pnatarajanmd

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

The intersection of: people who would be good at an admin job, people who want to do an admin job, and people who would be selected for an admin job is often an empty set.

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James 🥥🏈 Pirruccello

@jpirruccello

1 year

Smoking some cigarettes so I can get CHIP so I don’t get Alzheimer’s.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

As someone who ran web services for a decade, I will just say that serving up a form to 50,000 people ought to be pretty straightforward in 2020.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

I don’t understand why those of us who work in a hospital *aren’t* required to take periodic asymptomatic COVID tests. Meanwhile, we are continuously taking healthstream tests.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

I am annoyed with COVID but not from COVID.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

Workshopping a scary Halloween costume

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

The last time I left @skathire and @kiranmusunuru it was to send off a company that I had built. Today, Sek and Kiran are launching their own. Turnabout feels like fair play here! Now, have a blast, develop a great platform, and eradicate coronary disease.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

CC @jeremyphoward

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James 🥥🏈 Pirruccello

@jpirruccello

6 months

This is an interesting study but it doesn’t, by itself, establish causality. It is an important flagpole and it will spur good follow-up work. For completeness, it may be that the same thing that causes microplastic deposition also causes ischemic disease, making this a marker.

NEJM

@NEJM

6 months

Patients with evidence of microplastics and nanoplastics in carotid artery plaque, as compared with patients without, had a greater risk of adverse cardiovascular events at 34 months of follow-up. Read the full article:

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James 🥥🏈 Pirruccello

@jpirruccello

6 years

> It's "unconscionable ... an experiment on human beings that is not morally or ethically defensible," said Dr. @kiranmusunuru , a University of Pennsylvania gene editing expert and editor of a genetics journal. Well said.

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James 🥥🏈 Pirruccello

@jpirruccello

7 years

@DrSarahWakeman @choo_ek @AnupamBJena I don’t always mansplain topics outside of my expertise, but when I do, I make sure to do it at a forum about the problems women face.

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James 🥥🏈 Pirruccello

@jpirruccello

5 years

@eemoin "Cold hands warm heart" is basically my greeting. It doesn't even have a meaning to me anymore, just an obligatory utterance that I make.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Might open up a donut shop and call it Hole Foods.

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

@kathleen_belew Ænema by tool

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

Shout out to my friends who still get to do HealthStream training today. Sadly, I spent my year's HealthStream supply a few days ago and won't get to take a hit of that sweet, sweet pretest failure until December 2021.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Me, using my own code: Who the hell wrote this Why did they not document it And why are all of the comments lies?

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James 🥥🏈 Pirruccello

@jpirruccello

2 years

@pnatarajanmd Statins should be over the counter.

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James 🥥🏈 Pirruccello

@jpirruccello

4 months

Kind of obsessed with the chaotic nature of the Epic ‘Sent Messages’ folder. No alphabetical ordering. Dozens of categories. I dare you to try to find what you were looking for.

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Good morning, but only to @MGHCoffee

MGHCoffeeCentral

@MGHCoffee

3 years

Good Morning #MGH ! Today's Coffees: Caramel Nut Biscotti & Winter Wonderland. Muffins: Corn, Blueberry and Almond Joy, and Be Fit Apple Streusel Bran. Tea Bread: Cranberry Nut.

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James 🥥🏈 Pirruccello

@jpirruccello

6 years

Voting prevents coronary artery disease. No study has disproven this claim, and it would be unlawful to randomize.

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James 🥥🏈 Pirruccello

@jpirruccello

4 years

@spreekaway @paulg The 5000 trader limit that you pointed out and the $850 max limit make PredictIt an inefficient market. Basically free money on the table as long as the gain is >5% (the PredictIt withdrawal fee).

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James 🥥🏈 Pirruccello

@jpirruccello

3 years

Most of the biobank-based disease analyses that we are able to do right now are based on billing codes. Developing algorithms that reliably (or even reliably-unreliably) pick up diseases that don't have ICD codes would be a boon.

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