After building embryoids for 10 years, we succeeded in generating structures with brains, hearts, neural tubes, somites with a yolk sac. Both original submissions using two different approaches are on BioRxiv, to be published soon.
Our paper is finally out! After 10 years of model building we generate complete embryoids from three types of stem cells - they develop heart, brain structures and more. We show the first proof of concept knocking out a gene required for neurodevelopment
What is the origin of our body? Our paper
@CellCellPress
shows that when a human embryo is one day old and comprises just two cells, only one cell will create most of the fetus in addition to placenta, while the other cell will create placenta.
We are hiring an expert in live embryo imaging! If you are interested in early mouse and human development and would like to look at it in a new way, please contact me.
As someone who’s been mentoring future PIs for a while, I often get asked how I choose post-docs for my lab and if I have a crystal ball for predicting their success. Well, here is the scoop: I don’t! But here are some things I look for: (1/8)
I’m deeply honored to be chosen to deserve Conklin Medal this year. Special thanks to my amazing team of brilliant scientists at
@Caltech
and
@Cambridge_Uni
@PDN_Cambridge
Congrats to Magdalena Zernicka-Goetz
@ZernickaGoetz
@Caltech
@Cambridge
on receiving the 2022 SDB Edwin G. Conklin Medal for illuminating mechanisms of early mammalian embryogenesis through innovative techniques culturing post-implantation stage embryos.
First Human Blastoids
@Caltech
. Our long journey from mouse to human - it is 7 years since our first mouse prototype was published. Thanks to the first authors
@BernaSozen_
and my first PhD student
@Caltech
Victoria
We are looking for postdoctoral colleague to study cell fate choices using lights sheet and 2photon imaging of mouse natural and stem cell-derived embryos in California
@Caltech
. If you are interested, pls send me a message. Please RT.
Very happy I can finally share our experience with human blastoids. Beautiful morphology but EPES cells have limitations in lineage specification. Reconstructing aspects of human embryogenesis with pluripotent stem cells | Nature Communications
Finally we can share in full our long journey from mouse & human embryo implantation 10 years ago, through many mouse models, to this human embryo model. A decade long but a beautiful & fulfilling journey with wonderful people, too many to mention all here
1. I am an immigrant who came from communist-era Poland to the UK and then the US in a search of a more open, unfettered life. In Warsaw, even though my first home was a laboratory, I would have never dreamed that one day I would become a professor at Cambridge and Caltech.
Developmental clock and mechanism of de novo polarization started 7 years ago with the last 4 yrs critical. It took 2 yrs from the first submission. Each year
@zhumeng123
expanded the work and
@jake_cs_
added modelling. It feels so special.
So delighted to share our human embryo-like model that was published today
@Nature
We used it to study cross-talk between embryonic and extraembryonic cells in human embryos to generate amnion and PGC-like cells. Thanks to Bailey & Carlos in our lab for their hard work & insight
This honor means so much to me. Shinya Yamanaka is one of my heroes, and it’s incredible to be appreciated by my colleagues in his legacy for the research that I’ve devoted my life to. Thank you to all of my ex and current lab members, many will join me on the day.
Magdalena Zernicka-Goetz will be presented the 2023 Ogawa-Yamanaka Stem Cell Prize later this month. Read more about her work and why she was selected for the prize
Very happy to share our human embryo model. We generated human yolk sac stem cells and put them together with ES cells to study embryonic-extra embryonic interactions and specification of anterior patterning feel proud of my whole team and collaborators
Our study on human embryos identifying the symmetry breaking event to specify anterior is out! Thanks to my wonderful lab,superb collaborators,parents who donated embryos
@MZG_Lab
@roserventotormo
@TimCoorens
@Cambridge_Uni
@DrNadiaChaudhri
Nadia, you became the sun and the moon of my life over the last months. Before I start my day and before I end it, I check for your messages. However, small and big, they warm my heart to you.
Reflecting on a decade’s journey from concept to reality, truly humbled to see work in embryo culture and in vitro assembly honored as „Method of the Year” by Nature Methods. Pioneering this path was a collaborative dream - never did we imagine such remarkable recognition
Our Method of the Year 2023 celebrates recent methods for modeling development!
#moty2023
In a Comment,
@ZernickaGoetz
takes an in-depth look into the most recent embryo models that have been reported.
I’m excited to announce that we are looking for a Post-Doc. If you are excited about stem cells, embryos and live imaging and want to make impact in biology and medicine, join us! Tweet or email me. Please RT.
How embryos tell time has been in my mind for 20 yrs. To answer this we had to develop many tools, from clonal overexpression & lineage tracing to simultaneous KO of several genes in embryos. It paid off
@Caltech
@Cambridge_Uni
Thank you
@Nature
for featuring our work about how the very first division of the fertilized egg makes a lopsided contribution to the body’s organs and tissues.
Visited Heffers in Cambridge today and was surprised to find my book with
@RogerHighfield
. Signed all copies. Honoured to find myself next to
@ottolenghi
!
We are looking for a Lab Manger in our lab at Caltech, California. If you would like to help us run the lab and participate in some experiments too and have lab experience, please get in touch with me by email. The specifics are posted on the Caltech website.
My Division - Biology and Bioengineering- at Caltech is seeking to make multiple Faculty appointments on different levels. A broad call in an amazing place with rays of sunshine every day. To apply:
Hip hip hurray! So excited about modeling embryos from stem cells being chosen as the method of the year 2023 by
@Nature
and our floating embryos being on the cover of this special issue
It's that time of year!! 🎉We are so excited to announce our 2023 pick for Nature Methods' Method of the Year: methods for modeling development. Read the Editorial to find out why we chose this as our pick.
#moty2023
I miss Lewis Wolpert already. I will ever remember the sparkle of warmth and joy in his eyes. He asked me 15 years ago how many cells the mouse embryo needs to survive. We addressed it with
@morris_lab
and dedicated the paper to him. The number is 4.
We are looking for two new post-docs. One project is to work on early human embryo development and the other, on early mouse embryos and live imaging. If you are interested, contact me please RT
How the human embryo polarises - out today! Work started in my lab
@Cambridge_Uni
and completed in our new lab
@Caltech
. Many friends and colleagues helped us to complete experiments during Covid closure and setting up the new lab. I am so grateful to all
We have got a new program grant for our stem cell and embryo work and are looking for a staff scientist, post-doc and research technician. Proper advert out soon but for now contact magdaz
@caltech
.edu
So excited that my book
#TheDanceofLife
with
@RogerHighfield
has come out in Poland! Our book is about my journey as a women in STEM and my research. But more importantly it is devoted to women’s rights and what we know and still need to learn about the beginnings of our lives.
First celebration this summer in Cambridge for our human embryo stem cell model accepted in eLife. From the first submission took app. 2 years .. and many extra experiments. So proud of my team and especially Kirsty, Bailey and Marta here and wonderful collaborators Roser & Sam
This is our embryo model no5. Very similar to our model no4 published 2 weeks ago but now derived exclusively from stem cells that we programmed to specific fates. Huge thanks to 3 years of work from amazing PhD student Kasey & collaborators Hernan & Yonatan (not on Twitter)
New paper alert: Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development. From
@ZernickaGoetz
@MZG_Lab
and colleagues-
In response to recent media on my group’s research, I would like to clarify that our goal was not to make headlines but to share our research with the community. We cannot control how the news reports our discoveries, but we are grateful for the interest & constructive comments.
In this Women in Science week I wish to celebrate Kasey, my PhD student who started our zoom meeting by saying, I have great news for you and showed me the result we so much hoped for. Well done, Kasey 👏👏👏👏👏
I appreciate people who try to excel in their own projects but also engage generously with others in the lab and our collaborators. Teamwork makes the dream work! (3/8)
Our new paper brings insight into developmental potential of aneuploid human embryos beyond implantation until day 9. It won’t be possible without colleagues
@IVIclinics
@thermanetwork
and my
@MZG_Lab
being amazing!! Thank YOU
Here is our pre-print that we deposited at the same time - we are very happy to share our human embryo model that allows us to study a cross-talk between the tissues in the second week of our life. Wonderful collaboration with many amazing scientists in my lab and friends outside
Pleased to share our recent work generating a human embryoid model.
In light of recent press coverage which has unfortunately sensationalized our unpublished results, we feel it is necessary to provide a version of our data as soon as possible.
1/
The discovery of GFP by Shimomura changed my life in 1995 when i took a trip from Warsaw to join the lab of Martin Evans in Cambridge to establish GFP as a marker for gene expression and cell lineage. I am still on this journey :) I owe so much to Shimomura and many others
"I learned that any difficult problem can be solved by great effort."
Remembering Osamu Shimomura, born
#OTD
in 1928, who dedicated his life to studying the bioluminescence of the luminous jellyfish Aequorea, and discovered green fluorescent protein, GFP.
I look for thoughtful scientists who enjoy rolling up their sleeves and doing experiments themselves, rather than delegating everything to technicians. (4/8)
We are opening a new Stem Cell and Embryo Engineering Center at Caltech to establish state-of-the art mammalian embryo research and looking for a Director. For more information please see below or contact me by email
We are of course excited about our embryo-like model but wish to stress that it is important not to think of our embryo-model as being a real embryo - even if it is getting close to the real thing
I’ve been presenting our human stem cell embryo model, derived from programmed human ESCs, at conferences for a few years and last year, we finally published it. Now we’re excited to share a detailed protocol how to create these models
#StemCellResearch
We are very excited to share our findings on which cell to cell signaling interactions are crucial in the postimplantation human embryo in vitro. Thank you so much
@NatureCellBio
It has been my dream to address this question since my lab discovered a similar cell fate imbalance in the 2-cell stage mouse embryo 20 years ago. At the time, this was controversial and went against the dogma causing me nearly to lose my lab that only just, just started.
And then to complete our top 10 thinkers 2020 we have
@ZernickaGoetz
whose work growing embryos in the lab has profound implications for medicine—and human life
Most of the Abs we buy do NOT work. It would be amazing if companies know that they have to send a small sample first to verify if it works, before huge investment
Here is one estimate on money spent on failed antibodies.
I wonder how much is spent on following flawed hypotheses based on affinity reagents that we thought worked ...
Olga Tokarczuk got Nobel prize today! She has been my favourite writer in Poland and literature soulmate in thinking of crossing borders - here between science and literature at Hay Festival
Patience and creativity during tough times (like COVID lab lockdowns) are essential. Avoid those who ask to write their own reference letters and boast excessively. Good scientists are good human beings too. (6/8)
Once they join the lab, I try my best to empower them, encourage openness and transparency, and support them in presenting their data at meetings, sometimes even convincing conference organisers to let them present instead of me (5/8)
This is great news release - thank you Cambridge! Study identifies trigger for 'head-to-tail' axis development in human embryo via
@Cambridge_Uni
@EurekAlert
My life in 6 objects of which two are my book
#theDanceofLife
with
@RogerHighfield
that came out today in countries that adopted me, the UK and US. Million thanks to everyone who suggested writing a book and made it happen
@BasicBooks
@PenguinBooks
This is one of my favorite images of love and compassion and I totally understand the power of this type of brain’s reaction as a mother of two, but also as a daughter
Neuroscientist Rebecca Saxe presented this MRI image of a mother kissing her infant child, reflecting the brain's reaction. Dopamine is released causing a wellbeing reaction and also oxytocin known informally as the 'love hormone'
#WomensArt
❤
(via RGC, FB)
1. One of my favorite lab projects: uncovering when and how cells begin to differ from each other as they first form. A long journey of discovery that dared to challenge the norms of the field.
#StemCellResearch
Excited to share our latest preprint () from the
@MZG_Lab
and
@slavovLab
! Harnessing single-cell proteomics, we examine the earliest stages of symmetry breaking in mouse and human embryos *and* link these to developmental consequences 🥳
My life has unfolded in ways I never envisioned when growing up in a communistic Warsaw. So grateful to have found science that has guided me through and up to tracking lineages of cells in embryos with an amazing group of scientists who joined me. Thank you
@stemcellpodcast
💕
This is the first art project with my son this year - to decorate the empty walls of our new home. Me in red and Simon in back&white. I wish I have more time to paint and to be with him.
Hot off the press
@nature
! Very excited to share my PhD work and first major publication. We found a surprising new role for keratins as asymmetrically inherited fate determinants in the early mouse embryo:
With one of my favourite mentors John Gurdon in an outfit I designed and named “primitive streak” to honour one of my favourite structures in developmental biology
This is what my son painted while I was listening to most excellent talks by
@jvveenvliet
and
@LabSrinivas
at Gastrulation club this morning. He is missing his sister Natasha left in Cambridge so we all connected to Cambridge this morning in different ways❤️
As a a mother’s day present my Lab has a new website! So grateful to Justin Sengly and Sam Wagner for designing this website for us. From text to icons.
A present from my husband just arrived - a photo from just 20 years ago - still in a hospital in Cambridge. Tashi was delivered by C-section on that day.
“Ten years ago I was kicked out and forced to retire.”
Our new medicine laureate Katalin Karikó (
@kkariko
) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges.
Ten years ago, Karikó was still doing all her
When I arrived at our LA home, there was a wonderful gift waiting for me - the French version of
#TheDanceofLife
. I think I know my favorite - which cover do you like the most?
Many thanks
@Sergiu_P_Pasca
for the inspiring discussion in news and views in
@Nature
of complete (tri-lineage) mouse embryo models built from stem cells, their potential and their nomenclature
Lessons in History: Thanks to Peter Lawrence (Drosophila), John Gurdon (frogs), Bill Harris (zebrafish), and Andrzej Tarkowski (mice). Their pioneering work and support helped me navigate controversy and ignited my passion for developmental biology across models
#HistoryOfScience
”
@ProfBootyPhD
Indeed, our paper validates two decades of meticulous experiments, which once labeled me as a ‘controversial figure’ among senior male peers - a tough spot for a young woman starting a lab in a foreign country. Thankfully, open-minded colleagues helped me prevail. Cheers to them!
My beautiful girls are all growing in different but all exciting directions - the one in the middle just became preoccupied with neuroscience. How is it possible?