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Dr. rer. nat. Valentin Bruttel Profile
Dr. rer. nat. Valentin Bruttel

@VBruttel

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father, scientist, bioengineer, immunologist. CSO private account, all opinions my own supporter

Germany
Joined October 2019
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
the DEFUSE draft documents show that, exactly as we had postulated, they planned to use 6 SEGMENTS to assemble synthetic viruses, to use unique endonuclease sites that do not disturb the coding sequence, and TO BUY BsmBI!!! (= NE Bio labs order # R0580S or R0580L) 25/x
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
Now this is interesting: seems like a State Key Laboratory of Pathogen and Biosecurity scientist from Beijing uploaded a sequence from a 2019 Henan sputum sample. He thought it was from pseudomonas, but it is actually 100% the SARS2 spike without the FCS.
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@MartinaSisters
MartinaSisters
@MartinaSisters
1 year
@kurganson Estos son más de 1200 aa… de un virus que segun los científicos se parece al SARS… inténtalo otra vez, a ver si a la segunda convences más.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin So to sum this up: 1) SARS2 Omicron genome looks like it was "separated/frozen" between June 2020 and late summer 2021 - This has never before been seen in nature, only in lab leaked pandemics
1977 Russian flu - Wikipedia
en.wikipedia.org
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
The DEFUSE proposal has IMO always been a precise blueprint for how SARS2 came into existence. Now @emilyakopp and @USRightToKnow used the FOIA to get access to draft documents that contain further damning details. a 🧵. 1/x
@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
Did you ever struggle putting together some furniture? In case you'd rather build a SARS-CoV2 virus, just follow this super detailed 2018 step-by-step protocol by WIV and @Baric_Lab . bat-CoV+RBD+FCS➡️rev. genetics➡️hACE2+ cells ➡️🤒😷😱☠️⚰️ shockingly easy
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
How SARS2 was stitched together Nowadays,SARS2 like viruses can be generated in lab within weeks If this was possible in Wuhan 2018/19 is debatable. However, Shi Zhengli had 2 grants to investigate which manipulations enable bat viruses to go pandemic. 1/x
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@elonmusk Amazing progress @SpaceX & @elonmusk ! Next time, just tell Franz @woodhaus2 to hold back a little bit!😂 And please sell some of the SN10 scrap to fans,I would love to buy a small piece of history and support your mission! To moon and mars!🚀 pls RT if you agree! @Erdayastronaut
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
SARS-CoV-2: how we were misled and how molecular evidence proves a synthetic origin beyond reasonable doubt. Edited livestream presentation on origin literature issues, circumstantial and molecular origin evidence, the endonuclease fingerprint and Q&A
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SARS-CoV-2 origin: how we were misled and how molecular evidence IMO...

Scope:A molecular biologists/immunologists talk about the molecular evidence on the origin of SARS-CoV-2.For science reporters or informed lay persons, some ...

www.youtube.com
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
Dear all, it's been both pleasure and hard work to write this manuscript with @WashburneAlex and @tony_vandongen . The aim was to focus on a very peculiar observation made quite a while ago: a very suspicious pattern of endonuclease recognition sites in the genome of SARS-CoV-2.
@WashburneAlex
Alex Washburne
@WashburneAlex
2 years
Pre-print: Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2 A collaborative product by @VBruttel , @tony_vandongen , and myself. Here's what we found: 1/
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
8 months
@Tim_Roehn @MartinKulldorff @DrJBhattacharya Virologen: wir können nicht widerlegen dass SARS2 aus dem Labor kam. Drosten: Ok, verstehe. Aber fügt noch paar Referenzen in euren Artikel ein. Drosten 1W später: Ich verurteile Verschwörungstheorien um einen Laborursprung Drosten eidesstattlich: kannte o.g. Artikel nicht
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin IMO: omicron was collected&frozen ~06/2020, thawed ~04/2021, then passaged with various convalescent/vaccinated sera in vitro or rebuild as a synthetic polymutant. Made to investigate antibody resistance or as a 2nd generation vaccine. Then likely tested in hACE2 transgenic mice.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
Scientific & circumstantial evidence shows SARS2 originated from a gain of function experiment: We didn't investigate or tighten regulations. We now face the Omicron pandemic, and again, scientific evidence shows it's not a natural variant. a🧵
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SARS-CoV2 origin - English | Strictly scientific lab leak evidence

SARS2 laboratory accident origin evidence. Summary Basically, SARS2 is a: - bat coronavirus from S. China or Laos that can bind to human ACE2 - with a precisely integrated human-specific furin...

www.stopgof.com
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
DID THE MONKEYPOX (MPXV22) OUTBREAK COME FROM A LAB? location, transmissibility, number and type of mutations strongly suggest so😬 disclaimer: this is a PRELIMINARY analysis, a first look, an invitation to an open discussion,🙏rt! I hope to be wrong. But the data...😱 a🧵 1/x
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
Leaving Twitter Dear Friend, GoF research especially in the field of synthetic virology still is extinction level threat as @AshleyRindsberg recently phrased it. Despite constant ghost bans, Twitter was important to investigate the origin of SARS2. 1/
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Why are we still funding gain-of-function research?

'Gain-of-function and synthetic biology are increasingly risky because the technology has advanced in quantum leaps in the past decade'

thespectator.com
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@_FriedrichMerz @handelsblatt Was die CDU verboten hat: Solarstrom: -Dach voll nutzen⛔️ -Nutzung durch Mieter⛔️ -durch Nachbarn⛔️ -vom Bauern⛔️ -kostenlos selbst verbrauchen⛔️ -komplette Leistung nutzen⛔️ -verschenken⛔️ Effiziente Windkraft⛔️ Mrd für Kohle✅ Lebenswerte Zukunft⛔️ #VerbotsUnion #VoteThemOut
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 months
After major flaws were found in pretty much all papers pointing towards a zoonotic origin, it seems like ad hominem attacks against those who speak the truth is the last card those virologists can play👇
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@NewsfromScience
News from Science
@NewsfromScience
3 months
A dozen #COVID19 scientists have filed a formal complaint with Rutgers University alleging that two faculty members violated the university’s policies by posting “provably false” comments that are often defamatory and that could incite harm against them.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 2) SARS2 Omicron has 25:1 non-synonymous:synonymous mutations ratio. Natural evolution would result in 25:50-100 ratios. The only logical explanation here is targeted manipulation.
@P_J_Buckhaults
Phillip J. Buckhaults, Ph.D.
@P_J_Buckhaults
3 years
Omicrons (B.1.1.529) most recent common ancestor is AV.1. Relative to this MRCA, Omicron has 25 nonsynonymous and 1 synonymous mutation in Spike, and 13 nonsynonymous and 6 synonymous mutations in the entire rest of the genome. This is very strange & I don't understand.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
Remember, contaminations happen, this sequence could have come from another sample analysed in the same deep sequencing analysis. This strongly indicates that a 100% SC2-identical spike (minus FCS) was worked with in 🇨🇳 in 2019. Were 3nt (coding A) removed before adding the FCS?
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 3) No SARS2 Omicron predecessors have been detected between June 2020 and fall 2021, despite their supposedly already higher infectivity. So in this time, - a single isolated patient bred more mutations than >100Mio others? - survived continous infection in complete isolation?
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 6) Exactly this extremely risky research, which could render all of world wide vaccination efforts useless, was done in South Africa. And not even at their BSL4 lab, no, in Durban, which only has a BSL3 lab😱.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
@ethikrat @alena_buyx @noz_de Frau @alena_buyx , Sie und der Ethikrat standen in dieser Pandemie immer Seite an Seite mit denen, die diese höchstwahrscheinlich verursacht oder den Laborunfall vertuscht haben. Keine Lüge wurde hinterfragt. Nichts wurde aufgearbeitet. Auch deshalb gab es wohl weitere Unfälle.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
This is the DNA (or RNA) alignment: only 71.8 identical, which is extremely divergent for a sequence 100% identical on protein level (or I made some mistake...). Such divergence can originate from codon optimization for protein production/expression in another host, not natural.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
Molecular evidence clearly suggest a synthetic origin of SARS2 omicron. Tried to put the most relevant info into one easy to read blog: Still work in progress, but quite important. Please♥️or rt to help raise awareness and to stop the next synth. pandemic!
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SARS2 & Omicron | Strictly scientific lab leak evidence

Gain of Function Research of Concern (GOFROC) increases the pandemic potential or lethality of human pathogens. It is carried out by only very few laboratories all over the world, and many scientists...

www.stopgof.com
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
10 months
The DEFUSE proposal not only suggested to add a FCS and human ACE2-binding RBD to a bat coronavirus, but also to introduce N-linked glycosylation sites. Read this to understand how SARS2 has exactly such a site to bind to DC-SIGN, and why it is likely introduced.
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@ydeigin
Yuri Deigin
@ydeigin
10 months
1/ Besides the furin cleavage site (FCS), SARS2 has another unique feature mentioned in DEFUSE not yet seen in any natural SARS-like viruses – an ablated N-linked glycan at position N370. This glycan was ablated via a T372A amino acid mutation that came about via a double
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
first impression: the -sampling date (2019) -structure of the plasmid -100% (-FCS) identity to SC2 indicate that the exact SC2 spike was handled in labs in China, possibly to do experiments as described in the DEFUSE proposal (FCS then added later according to same proposal)
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
I wrote worked with, as the rest of the seq. looks engineered: -the first 21aa seem to come from a human plasminogen activator -the following 8aa (GGGSGGGS) could be a flexible protein linker -what's that IEK rich domain that follows? Could this be a protein vaccine spike?
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
One of the best informed fellow scientists fighting COVID origin desinformation has left the battlefield now that independent investigations have finally begun. AFAIK he was doxxed and almost lost his job. Thanks for everything you sacrificed for the truth and for our safety! 🖖
@virologyanon
Anonymous Virologist PhD 🦄
@virologyanon
1 year
Thus departs a true hero, three cheers for @pathogenetics Sherlock G.Nomes Ph.U.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 5) The only plausible explanation how this huge number of mutations could have been acquired completely below the radar is: - scientists enabled SARS2 samples to escape antibody responses by passaging them in presence of diluted convalescent serum on human/humanized cell lines.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
Dear @biorxivpreprint . 20 mio died from COVID. You rejected 2 highly important preprints that found the most ancestral SARS2 genome with DNA of lab cell lines. Kristian Anderson said a lab accident "highly likely", but published opposite. Was he involved in censoring the papers?
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
@MarionKoopmans I am an immunologist and bioengineer, and I am convinced SARS2 came from a lab based on the molecular evidence. Would you willing to lay out your perspective, to discuss the origin evidence in a public zoom call? I am sure many would be interested!
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
🧐 Airborn pathogen kills many near biosafety lab. Ruling communist party blames local meat market. Western experts confirm natural origin without on-site access. Overwhelming data points towards lab leak. Leak admitted after 13y/communist system collapse.
Sverdlovsk anthrax leak - Wikipedia
en.wikipedia.org
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
Kurz zum Thema Wiesendanger/Drosten: -halte große Teile der dt. Berichterstattung über Prof. Wiesendangers Quellenstudie für schlechten Journalismus (viele ad hominem Angriffe, kaum Diskussion von Fakten) -halte ihn für einen exzellenten Wissenschaftler und sehr integren Menschen
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
Did you ever struggle putting together some furniture? In case you'd rather build a SARS-CoV2 virus, just follow this super detailed 2018 step-by-step protocol by WIV and @Baric_Lab . bat-CoV+RBD+FCS➡️rev. genetics➡️hACE2+ cells ➡️🤒😷😱☠️⚰️ shockingly easy
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
8 months
@garyruskin Fantastic, thank you so much! Pleased keep your eyes open for the terms "variable/highly variable virus", "infectious clone", type IIs (enzymes), BsaI and BsmBI. Esp. in conv. with Daszak, SZL, Linfa Wang, UNC virologists. Happy to elaborate. Thank you!
@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
@Graybea71861266 @harishseshadri2 @WashburneAlex tbh, I think Baric immediately knew this virus was synthetic, one with his "highly variable" design. Drosten knew after I send him all the fingerprint details via mail June 2021. But the proximal crew are not bioengineers, the BamHI comment is stupid, they maybe didn't know.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 7) Durban, as you mentioned above @ydeigin , is exactly the city where omicron was first detected in one of the patients. Where they "trained" SARS2 variants to become resistant to neutralizing antibodies by slowly and carefully increasing covalescent plasma concentrations...
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 month
So, PR guy/influencer Philipp Markolin, who spread tons of disinformation on COVID origins and verbally attacked many scientists that asked for a proper origin investigation, worked for RicoHealth Alliance... And never mentioned any COIs... Great job @Florin_Uncovers
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@Florin_Uncovers
Florin
@Florin_Uncovers
1 month
Biased pandemic origin influencer @Philippmarkolin lied he didn't have any links to Peter Daszak! He recently posted bat sampling pics to prove his Biology credentials. I locate one photo to a bat sampling trip in Thailand funded by PREDICT & NIH NIAID CREID grants to Daszak!🧵
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 4) Omicron is better adapted to humans and likely also to vaccinated/recovered humans. If this was acquired in a large pool of humans, we would have seen predecessors of this variant before. Evolution in animals should have resulted in a less-well adapted variant.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
@emilyakopp just published her analysis here: Excellent article! Thanks again for getting access to these documents! As I had discuss a few more points in my thread, here is the whole thing again👇
US scientists proposed to make viruses with unique features of SARS-CoV-2 in Wuhan

American scientists planned to work with the Wuhan Institute of Virology to engineer novel coronaviruses with the features of SARS-CoV-2 the year before the virus emerged from that city.

usrtk.org
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 month
This shows how many virologists besides the dishonest "proximal origin" authors, such as @angie_rasmussen or @stgoldst , knew that NIH employees tried to hide evidence from the public. Millions died, not one the virologists reported this.
@JamesCTobias
Jimmy Tobias
@JamesCTobias
1 month
This is the email from Morens that first drew the ire of Congress. Morens was a long-time senior adviser to Dr. Fauci. Since this email surfaced, @COVIDSelect has subpoenaed Morens and obtained some 30,000 of his emails. He testifies before the subcommittee at 2 PM Eastern today.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
Hey Kristian Andersen, if your lab wasn't responsible for what you call the Ebola lab leak, which lab was? Why was your Ebola NIH grant not extended? Why did Robert Garry say you worked on Ebola in 2014, and now he says you didn't? Ever heard of BSL4 pathogen handling rules?
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@CD57227
CD8
@CD57227
1 year
"It's the same people who have been doing this for decades, right? And the problem is that people see these coincidences. One of the new ones is the Ebola lab leak, which also is being blamed on us." Wait, you're not supposed to say it was a lab leak! 😄
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
4. according to the DEFUSE proposal, there were plans to characterize and reconstruct SARS-like spikes, and to put them into nanoparticles. this construct may have been used to express the spike in e coli to -test binding to hACE2 -produce spike for a bat vaccine
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
The recent #RaccoonDogHoax proved that a) Zoonati have left the realms of objective, responsible scientific investigating &reporting. Facts will not change their minds. The truth is just too terrible. b) There really is no evidence for a zoonotic origin 2/
The Strongest Evidence Yet That Major Media Outlets Fail in the SARS-CoV-2 Origin Question

How large media outlets hyped an obviously flawed report before it was even published

vbruttel.substack.com
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@TheSalonniere @ydeigin Why did none of the NSA employes talk about how they broke the law by spying on americans on a daily basis for years? Why did none of the VW engineers talk about how their clean diesels were killing people? Why was Chernobyl staff not informed about known reactor design flaws?
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Dr. rer. nat. Valentin Bruttel
@VBruttel
4 months
what it feels like to be a scientist 🙏 @WashburneAlex
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Dr. rer. nat. Valentin Bruttel
@VBruttel
8 months
🧵How few anonymous accounts censor Wikipedia with regards to the origin of SARS-CoV-2, and why you should supporting Wikipedia until this is resolved. I love Wikipedia. It's a great place to start reading into new topics, to find relevant literature, to look things up. 1/
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
@BioSRP @pricklyresearch @thackerpd @R_H_Ebright @mattwridley @franciscodeasis @gdemaneuf @WashburneAlex @Ayjchan @alisonannyoung @BillyBostickson @nicholsonbaker8 @Bryce_Nickels @ydeigin @tony_vandongen @angoffinet @mbalter @ryangrim @BiophysicsFL @atuntable @ColinDavdButler Ebola 2014 really starts to look like a lab leak. Terrible lab safety. Infected lab workers. Ebola never seen in 2500km radius before. Garry said 2014 and Andersen 2023 that they started Ebola projects in Kenema (and had a NIH grant), now Garry insists they did not work on Ebola.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
What we learned this WE: -syn version of 100% identical SC2 spike optimized/tested in 🇨🇳(Beijing?) 2019 -FCS (without which this virus would not have killed a single person!) added afterwards -lab safety so abysmal the spike and the virus leaked in separate instances I'm out 🖖
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
and restriction site pattern, leaked synthetic spike-coding plasmids... IMO the a lab origin of SARS-CoV-2 is proven beyond reasonable doubt. Still, please draw your own conclusions. please consider supporting @emilyakopp , @USRightToKnow or ! thanks! 30/30
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Biosafety Now! - Biosafety Now

Biosafety Now, a non-governmental organization that will advocate for reducing numbers of high-level biocontainment laboratories.

biosafetynow.org
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
Again, the most likely explanation is an accident. But this doesn't help the millions dying from Omicron. We must stop gain of function research on dangerous pathogens:
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(PDF) HAMBURG DECLARATION 2022 Call for a Global End to High-Risk "Gain-of-Function" Research on...

PDF | The current pandemic shows us what happens if pathogens become easily transmissible from human to human, even if the mortality rate of a virus is... | Find, read and cite all the research you...

www.researchgate.net
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
Virology has become a cult. First they sent Daszak to investigate. Now @MichaelWorobey thinks Linfa Wang would be unbiased about a lab leak. Wang was part of the Preempt Proposal, knew the WIV planned to put FCSs in ACE2 binding BatCoVs, and never told anyone about this!
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@MichaelWorobey
Michael Worobey
@MichaelWorobey
2 years
This assertion by Emily Kopp is not correct. Zhengli Shi welcomed Linfa Wang to visit her lab in January 2020 (best sweater in the attached photo from 15 Jan). These are the people that people like Emily are blaming for killing millions. Guilty looking bunch, eh?
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
This sequence is longer and seems to contain some additional pseudomonas genes, possibly explaining why it was mislabeled (I'm not a sequencing/annotation expert) Also Henan 2019, but from urine. More on Bioproject:
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@raqueltobes
Raquel Tobes
@raqueltobes
1 year
@MartinaSisters @VengefulArzt Here data of the Bioproject:
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Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
@WashburneAlex , @tony_vandongen and I had written preprint in which we describe that the SARS2 genome contains a pattern of restriction sites typically found in synthetic, but not in related natural viruses. 21/x
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Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2

To prevent future pandemics, it is important that we understand whether SARS-CoV-2 spilled over directly from animals to people, or indirectly in a laboratory accident. The genome of SARS-COV-2...

www.biorxiv.org
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
8 months
The award for the most idiotic article on SARS2 origins Nov. 2023 goes to @ElizabethFinkel and @THEMONTHLY . Wuhan virologists uploaded a 99.5% SARS2-identical section of a virus in 2018. Linfa Wang planned to introduce furin cleavage sites and hACE binding RBDs into such viruses.
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@THEMONTHLY
The Monthly
@THEMONTHLY
8 months
“Virologist Linfa Wang puts it more bluntly. Until nature had showed us what it took, he tells me, ‘no scientist, smart or rich, would be able to make SARS-CoV-2’.” Elizabeth Finkel debunks the #COVID19 lab-leak theory
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 10) IMO someone: 1. bred different antibody-escape-mutations w/ diluted convalescent plasma 2. maybe also wondered what happened if those were combined & made a recombinant AV.1. SARS2 variant with all these mutations for 3000$ 4. inhaled some aerosols/dropped a flask ➡️ omicron
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
before getting into wild "just a contamination/later vaccine" speculations, read this paper: identical -city (Beijing) -plasmid (pCDNA3.1) -codon optimization -plasminogen activator (MDAMKRGLCCVLLLCGAVFVSN) -WIV collaboration Just add a 2 to SARS-CoV...
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Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 8) and not just any SARS2 varian, no the had sampled their viruses in JUNE 2020, when the closest omicron relative was last seen out there. And not any variant, no, e.g. a B.1.1.117, B.1.1.1 and a B.1.1.56 virus. Omicron is B.1.1.529, sounds somewhat similar, right?
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
Quick update. 1. thanks for the great discussions in this 🧵! 2. the longer sequence clearly shows the SC2 identical spike without FCS is expressed in a very common lab plasmid, pcDNA3.1 3. that last bit may be a transmembrane domain according to @Daoyu15 (follow him!)
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Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
I explain in detail how a DEFUSE-like research project would explain all the oddities that cumulatively prove a lab origin of SARS2 in this academic talk: The new draft documents can be found here: 2/x
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Dr. rer. nat. Valentin Bruttel
@VBruttel
6 months
@ch_zimmer @MJnanostretch @M1tchRosenthal @harishseshadri2 @stevenemassey @quay_dr @BiophysicsFL @gdemaneuf @Biorealism @Florin_Uncovers @DavidBahry one aim of DEFUSE-like projects was to show that few recombination events/mutations enable bat CoVs to cause pandemics. They suggested to introduce "human specific" cleavage sites as such recombinations could occur in humans. The SARS2 FCS is identical to a human lung enzyme FCS.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
@Ayjchan @R_H_Ebright @ch_zimmer @jbkinney @gtuckerkellogg @andrewtanyongyi @Samuel_Gregson @AtomsksSanakan @WashburneAlex @acritschristoph Dear @Ayjchan , I tried to raise awareness to this for a year now. WIV use BsaI and BsmBI/Esp3I sites before to make synthetic WIV1 variants. And exactly those sites appear in a "silently introduced, perfect for synthetic assembly" pattern in SARS2, but non of its nat. relatives.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
22 days
so, Ben HU was - constructing synthetic viruses at the WIV - receiving lots of US money - patient zero according to US government sources was the first SARS-CoV-2 genome, "Wuhan-HU-1", also named after him?🤔 😉😇🤣
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Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
CONCLUSION These documents provided further insights into what gain of function experiments virologists connected to the WIV were planning. Location, timing, the traceless introduction, the divergent RBD and inserted FCS, the glycosylation sites, restriction enzyme choices.. 29/x
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
There has also been less constructive criticism, @K_G_Andersen 🤔 Some virologists prefered using insults, calling this kindergarten science. They also blocked us, so that we can't even react to the comments. Decide for yourself which you consider kindergarten behaviour.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
3 months
@emilyakopp Daszak prioritized saving a few $$ over safet and planned to move dangerous work to less safe conditions in China without telling the reviewers
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Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
Daszak also seemed to be proud that they can do these experiments under “highly cost-effective” BSL2 conditions. BSL2 is cost-effective as it is also very unsafe, it does not even mandate simple face masks. 27/x
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
@ydeigin Only logical explanation I see
@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
@gadboit @BiophysicsFL @WashburneAlex @lab_leak @BallouxFrancois @Kevin_McKernan @franciscodeasis @stevenemassey Did you know that the 2021 Ebola strain didn't mutate for 5 years? Either the laws of evolution don't apply to virology, or there is a culture of 🙈🙉🙊 whenever an accident happens. Like in the NSA, VW or catholic church, just much much more dangerous...
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
@CD57227 Eddie Holmes 2018: submits a 99.5% SARS2 identical RdRp together with Shi Zhengli to NCBI. Eddie Holmes 2022: "no one can know if the WIV had a potential ancestral virus prior to the pandemic". Philipp Kreacher Markolin and BoyBadAtScience: "sounds legit"
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Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 9) of course they used cell lines transfected for human ACE2, and froze their viral samples, which still is the only logical explanation for omicron completely splitting off from all other variants of in June 2020.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
The cumulative evidence, which many may not know or understand, proves a synthetic origin of SARS2 beyond reasonable doubt: I am proud that @WashburneAlex and @tony_vandongen an I have contributed an important puzzle piece here 3/
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Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2

To prevent future pandemics, it is important that we understand whether SARS-CoV-2 spilled over directly from animals to people, or indirectly in a laboratory accident. The genome of SARS-COV-2...

www.biorxiv.org
@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
@stevenemassey @harishseshadri2 @theodora_nyc recommended self test: if you do not know/understand -synthetic 🇨🇳 ZC45, HKU4, Nipah papers -DEFUSE proposal -ENaCalpha FCS -Csabai antarctica paper -BsaI/BsmBI pattern/mutation rate -2019 SC2 spike pseudomonas samples you may just not know the relevant lab accident evidence.
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
If you are interested in the following topics, please join in tomorrow (DM or comment + follow for zoom link) or watch that video once it is online. Further Q&A maybe in a twitter space with @BiosafetyNow ? Farewell for now, and please keep up this important fight for truth!
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Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
Great thread by IMO one of the best informed scientists without COIs when it comes to the origin of COVID. If we would have listened to Richard Ebright and a few other, we could have prevented this pandemic. I also failed to pay enough attention to this topic before 2019.
@R_H_Ebright
Richard H. Ebright
@R_H_Ebright
5 months
@FantomeCoeur Yes. Beyond reasonable doubt.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
one would never use pCDNA for a vaccine for humans according to @Daoyu15 ➡️IMO this is not part of an SARS2 assembly attempt, but part of an experiment to figure out how to design SARS2, which spike to use, or part of an unususal bat vaccine design
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
if true, this is by far the strongest non-molecular piece of evidence that basically proves SARS-CoV-2 came from the WIV:
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
1f Omicron didn't evolve new mutations. It copied existing ones. Again, natural SARS2 VOC evolution resulted in 3-6 new spike muts. Omicron, just like synthetic spikes, copied ~25 muts known in July 2021 from other variants or immune escape experiments! This MUST be designed!
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@InWuchang @TheSeeker268 Gain of Function research has become very cheap, easy and thus extremely dangerous, especially in virology. We need: 1. an immediate moratorium on all pathogen GoF experiments 2. an International GoF Control Agency 3. strict international experimental & reporting guidelines
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Dr. rer. nat. Valentin Bruttel
@VBruttel
8 months
In 2020, @NatureMedicine played the lead role in the SARS2 origin cover up, preventing urgently needed biosafety discussions. In 2021, @Nature helped cover up the almost certainly lab origin of an Ebola outbreak: Now this. @JMinImmunolandcan should resign.
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@Bryce_Nickels
Bryce Nickels
@Bryce_Nickels
8 months
The editor of Nature Medicine has chosen to block me rather than provide an update on the status of a letter co-signed by dozens of STEM & STEM-policy professionals we submitted 105 days ago. What does his decision reveal about transparency and ethics in scientific publishing?
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Dr. rer. nat. Valentin Bruttel
@VBruttel
4 months
@DrHermiz sorry to see you leave. other people often fear that looking into the origin of SARS-CoV-2 leads to controversy and economic or reputational losses. what they should really fear is what will happen if everyone stops looking into origin of SARS-CoV-2. thanks and all the best! 🖖
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Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
@VaccaRules @pathogenetics @quay_dr @MichaelWorobey IMO a FCS could evolve in a random bat-CoV, e.g. in a new host. But that's not the question. The question is: what is the chance that a 100% human-typical FCS with extremely unusual codons is suddenly inserted into a virus with an RdRp 99% identical to one (4991) used at the WIV?
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Dr. rer. nat. Valentin Bruttel
@VBruttel
2 months
excellent summary on SARS2 related strains, WIV sampling and FCS design by @ydeigin ! The only part I disagree with is the closing statement: "while we do not yet have certainty in any particular Covid origin scenario". Here, I'm with @R_H_Ebright 👇
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Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
I highly value any constructive, scientific critizism. Please no "you are not a virologist BS". Also, I accept things as true if >99.99% certain. Nothing is ever 100% in science. Let's get started Part 1: Why Omicron isn't a natural variant Part 2: Where could it have come from
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 month
@MarionKoopmans disinformation such as that a lab leak of SARS-CoV-2 is debunked?
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
@raouljdegroot @peter_berghmans @IBonnx @MarionKoopmans @EckerleIsabella Just FYI: this shit is going down at #Nido2023 atm: - conference blocked me before it even started - long refuted "2 jumps" fantasy put on stage - @ProfVolkerThiel actively censors opposing views/removes scientific articles - @flodebarre hinders scientists from asking questions
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
8 months
➡️ @Wikipedia allows a few anonymous bully editors such as "TarnishedPath" or "Bon courage" to insult, to threaten, and most importantly to delete comments written by transparent expert bioengineers. Thus, it should IMO not be financially supported until this gets resolved. 10/
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 month
@MarionKoopmans I'd like to report harassment. Virologists insulted me and colleagues in public while knowingly lying about my work and generated a virus that infected my family and killed friends. What should I do?
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
@MarionKoopmans I'd be genuinely interested if you do or do not see the COI when the same person that planned to put a human FCS into a hACE2-binding SARSr-CoV in Wuhan also leads a commission to investigate the outbrake of a hACE2-binding SARSr-CoV with a human FCS in Wuhan.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
We posted this as a preprint to invite constructive critizism. This may not be the final paper yet. But I'd like to take the chance to thank @jbkinney for his detailed comments and @R_H_Ebright and many others for interesting twitter discussions starting👇
@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
How SARS2 was stitched together Nowadays,SARS2 like viruses can be generated in lab within weeks If this was possible in Wuhan 2018/19 is debatable. However, Shi Zhengli had 2 grants to investigate which manipulations enable bat viruses to go pandemic. 1/x
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
That was quick, "just a contamination, nothing to see here" mail from from the "Military Medical Sciences Institute" in Beijing already out. Did NIH already remove some sequences? Like they did when a direct SC2 ancestor was found in another contamination?
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@MartinaSisters
MartinaSisters
@MartinaSisters
1 year
Please, important‼️ RETRACTED The sequence was a sequence contaminated. I guess the PhD will give a convincing explanation about this mistake. 🤔 @VBruttel @Jikkyleaks @tony_vandongen @raqueltobes
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
Also, such a trial would explain why there isn't just one Omicron: BA.1, BA.2, BA.3 look like recombinations of slightly different parts of the same vaccine spike with different backbone viruses as likely present in different HIV patients. Tried to publish this w/ @tony_vandongen
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Dr. rer. nat. Valentin Bruttel
@VBruttel
7 months
Kritisch ist dies, da schon gezeigt wurde, dass DNA aus Impfstoffen in die Genome von Zelllinien integrieren kann. Selbst in Patenten von Moderna war vermerkt, dass die DNA unbedingt entfernt werden muss, da es sonst zu Tumoren kommen könnte.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
@SolidEvidence Of note, most of those who commented blocked us first, possibly to prevent counterarguments.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
The problem now is not a lack of evidence, it's that evidence is not known/understood. I will thus present the IMO key evidence with explanations for informed lay persons via zoom tomorrow, March 26, 8pm Berlin/3pm EDT. Recording will be made public. Comment👇for invite link. 4/
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@VBruttel
Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
The preprint is IMO still being censored by journals. Virologists such as @DolkenL said our analysis was flawed (), claiming that the aim must have been to replace the entire spike (not the FCS and RBD)... 23/x
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Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
Change in policy. I will now block those who have first blocked me and then in many cases spread misinformation about me or my work. TBH, I am sick of this cowardly behaviour.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 month
Canadian virologists sent some of the deadliest viruses in the world on a commercial flight to Wuhan in 2019. They planned to use inappropriate packaging...
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Dr. rer. nat. Valentin Bruttel
@VBruttel
15 days
This shows why self-regulation NEVER works. Conflicted virologists always cared more about avoiding investigations and biosafety discussions than about millions of lifes. And @ScienceMagazine suppressed clear lab origin evidence while propagating clearly faulty origin papers.
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@kakape
Kai Kupferschmidt
@kakape
15 days
“It’s being used as a way to prop up a debate about the regulation of the life sciences which I think is probably in bad faith”, @neva9257 tells me about yesterday’s report by House Republicans investigating a proposed mpox experiment they deem risky.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 11) The most sickening part is that all of this work could have been done with basically no risk by just putting the spike protein into a harmless pseudovirus. Like done here: With strikingly similar results btw:
@theodora_nyc
Theodora
@theodora_nyc
3 years
I wish I was as optimistic @jbloom_lab Our polymutant spike has 20 aa substitutions and is almost completely resistant to neutralization by almost all vaccinated and convalescent plasma we tested. This new one has more in overlapping regions.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
1 year
a must read. i don't know how you uncover all these things, just wish we had equally good investigative journalists in 🇩🇪/🇪🇺. chapeau👏 @USRightToKnow
@emilyakopp
Emily Kopp
@emilyakopp
1 year
We obtained the classified notice that the Chinese government sent to labs ordering them to turn over viral samples or destroy them on the spot in the name of "biosafety." The destruction of some of the earliest viral samples has reportedly clouded the U.S. intelligence
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Dr. rer. nat. Valentin Bruttel
@VBruttel
3 years
@ydeigin 12) These are just my thoughts Saturday morning 2.30am after an intense work week. Please correct me whereever I may be wrong. This deserves a proper investigation that goes into the labs. Fact is that virologists keep doing highly risky research at very questionable conditions.
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Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
Disclaimer 2: Please leave all your -ad hominem/you're not a virologist -monkeypox is harmless -but some expert said something else -you're a conspiracy theorist -first prove it 100% arguments at home. Point out -analytical mistakes -opposing data -better explanations please! 2/x
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Dr. rer. nat. Valentin Bruttel
@VBruttel
5 months
We postulated that SARS2 was a) assembled from 6 fragments b) using a restriction enzyme called BsmBI for the backbone (BsaI for RBD or FCS variants) c) these restriction sites were introduced with abnormally many synonymous mutations 22/x
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Dr. rer. nat. Valentin Bruttel
@VBruttel
2 years
direct link to bioRxiv: Please do point out anything you deem incorrect, and also comment on clarity or on which points require further expanations. Stay tuned for a 🇩🇪 summary of our findings!
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