Rebecca Berrens @RBerrens Twitter profile

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Rebecca Berrens

@RBerrens

10 months

Excited to share that I got the @wellcometrust Career Development Award funding my lab for the next 8 years @UniofOxford to study locus specific #transposons in development! Thank you to all my mentors and students who helped along the way. Watch this space for open positions!

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Rebecca Berrens

@RBerrens

3 years

Very happy that our single CELl LOng read RNA sequencing (CELLO-seq) method for locus-specific #TransposableElement expression is out in @NatureBiotech today! Find the paper here: 1/n

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Rebecca Berrens

@RBerrens

4 years

Very happy to share our latest preprint describing our new method single CELl LOng read sequencing (CELLO-seq) for full-length #allelic , #isoform and #TransposableElement (TE) expression at unique loci resolution 1/n

Transposable element expression at unique loci in single cells with CELLO-seq

The role of Transposable Elements (TEs) in regulating diverse biological processes, from early development to cancer, is becoming increasing appreciated. However, unlike other biological processes,...

www.biorxiv.org

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Rebecca Berrens

@RBerrens

6 months

Excited to announce a Wellcome Trust funded *8-year* Senior #postdoc position in my lab @IdrmOxford : Understanding the role of locus-specific #Transposons expression in cell fate decision. DM or email me for more info! See

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Rebecca Berrens

@RBerrens

6 years

I am really excited that I have been awarded the Sir Henry Wellcome Postdoctoral Fellowship by @wellcometrust to work on single cell and single molecule analysis of #transposons during early mammalian development using @nanopore technologies @CRUKCambridge

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Rebecca Berrens

@RBerrens

10 months

Are you interested in doing a PhD on #transposons using a cutting edge RNA-sequencing technology together with us at @OxPaediatrics @UniofOxford as part of the Oxford-MRC Doctoral Training Partnership together with @nanopore ? Please apply here:

Target enrichment of transposable elements for direct RNA sequencing

www.medsci.ox.ac.uk

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Rebecca Berrens

@RBerrens

1 year

We have an opening for a research assistant in the Berrens group. If you are interested in #Transposons or jumping genes during development involved in gene regulation please consider applying or share with people who might be.

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Rebecca Berrens

@RBerrens

1 year

Barbara McClintock is a true inspiration for all scientists and especially as a woman in science a superhero! Her insights and predictions about transposable elements are incredibly accurate and keep feeding our research to date #TransposonDay2023

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Rebecca Berrens

@RBerrens

5 months

Excited to have played a small part in the recent paper by @CarrollDonal lab which identifies SPOCD1 required for human male fertility and #transposon silencing. C19ORF84 binds SPOCD1 and thereby bridges the piRNA and methylation machineries in vivo

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Rebecca Berrens

@RBerrens

4 years

Maybe it's just me but although I see the benefits in virtual conferences, I think poster presentation is getting even less attention than in "in person" conferences. #ScienceTwitter

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Rebecca Berrens

@RBerrens

4 years

Great collaboration during my Phd at the @reiklab with @bernthie is now out as a preprint. It is a massive study on DNA methylation repelling HIF TF bdg - demethylation allows HIF binding at LTRs leading to #transableelement -transcript expression.

DNA Methylation Repels Binding of HIF Transcription Factors to Maintain Tumour Immunotolerance

Background Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question...

www.biorxiv.org

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Rebecca Berrens

@RBerrens

6 years

Our latest paper shows that maternal overnutrition causes addictive-like behaviors, obesity and insulin resistance in offsprings (<= F3) without changes in sperm methylome. Great collaboration with Raibstein, Wolfrum @ETH_en and @Reiklab at @BabrahamInst

Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal...

Translational Psychiatry - Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition

www.nature.com

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Rebecca Berrens

@RBerrens

1 year

We have already 859 #transposon researchers in our TransposonWorldwide Slack channel. Please spread the word to keep this great resource going and to connect, share and help each other!

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Rebecca Berrens

@RBerrens

9 months

Our department @OxPaediatrics at @UniofOxford is advertising DPhil (i.e. PhD) projects. These are not directly funded but a number of studentships are awarded via a competitive process. Want to do a PhD studying #transposons ? Get in touch.

Transposon Group

The Transposon Group is interested in the role of locus-specific transposable element expression in development.

www.paediatrics.ox.ac.uk

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Rebecca Berrens

@RBerrens

4 years

I am presenting CELLO-seq for long read single cell sequencing on the 9th TE journal club meeting on Tuesday 20th October 5.30pm (GMT+1) ( ) Please register here:

9th TEjournalClub Meeting

9th TEjournalClub Meeting Twitter hashtag: #TEjournalClub on 20-10-2020 Time: 11:00 AM (EDT) / 3:00 PM (UTC) / 5:00 PM CEST / 4:00 PM (UK time) / 6:00 PM Moscow Target paper: Transposable element...

docs.google.com

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Rebecca Berrens

@RBerrens

5 years

Are you studying transposons? Would you like to get connected with other people in #Cambridge who study #transposons ? We are trying to generate a “Transposon Network Cambridge”. Please PM me if you are interested so we can setup a slack and gather interest for monthly meetings.

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Rebecca Berrens

@RBerrens

4 years

Have a look at my recent talk at the @Nanopore community meeting if you are interested in studying #transposable elements at unique loci in single cells using long reads. It was great fun taking part in the meeting with loads of new advances in long-read sequencing!

Oxford Nanopore

@nanopore

4 years

@rberrens investigated TE expression at unique loci with CELLO-seq. Currently 'problems reside with unambiguous mapping of short cDNA reads' whereas, with long reads 'we were able to get full-length transcripts’ & 'have less bias than the short-read data’

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Rebecca Berrens

@RBerrens

1 year

It is great to be finally able to share our research in the Berrens lab with everyone @IdrmOxford to be able to collaborate more and use this amazing setup of diverse researchers and harness their experiences for interdisciplinary science!

Dr Iris Hofmann

@IrisHofmann83

1 year

@RBerrens gives an overview of her fascinating research into transposable elements! We are very proud to have her on board as our first @IdrmOxford Transition Fellow!

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Rebecca Berrens

@RBerrens

6 years

I am happy to present our new method on #ONT RNA-seq in #singlecells for alternative splicing, allele specific and #transposon expression @GurdonInstitute #RNAclub

Gurdon Institute

@GurdonInstitute

6 years

REMINDER: Cambridge RNA Club tonight @GurdonInstitute

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Rebecca Berrens

@RBerrens

2 years

Very happy to join @ReubenCollege as one of their research fellows!

Reuben College, Oxford

@ReubenCollege

2 years

Absolutely delighted to welcome our first cohort of Research Fellows! Give those of them who are on Twitter a follow, they're doing some fascinating research: @MOUGK @RBerrens @SaherHasnain @JoshuaABull @gabi_pavarini @GemHughes

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Rebecca Berrens

@RBerrens

2 years

I love overhearing people in the lab now talking about #transposons harboring a lot of biology and should not just be masked. Making slow progress :)

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Rebecca Berrens

@RBerrens

5 years

I created a Worldwide TE channel. Any #transposon enthusiast please join! …

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Rebecca Berrens

@RBerrens

6 years

New paper on rewiring the transcriptome during spermatogenesis by #transposons . Great collaboration with the O’Carroll, Enright and @ReikLab at @BabrahamInst :

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Rebecca Berrens

@RBerrens

4 years

Join us at the @nanopore community meeting to discuss #transposon expression at unique loci at single-cell resolution with CELLO-seq.

Oxford Nanopore Events

@NanoporeConf

4 years

Full-length isoform characterisation, transposable element expression and transcriptome sequencing at single-cell resolution -- don’t miss Christoph Dieterich, @mritchieau & @rberrens in the single-cell breakout at #nanoporeconf . Register now:

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Rebecca Berrens

@RBerrens

5 months

very proud PI moment to read the interview of your first DPhil student talking about her research in the transposon lab Oxford! #newPI

Lauryn Deaville

Meet Lauryn Deaville, a DPhil Student in the IDRM's Berrens group. Lauryn studied biochemistry at Oxford before joining the Berrens lab to investigate locus-specific expression of transposable

www.idrm.ox.ac.uk

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Rebecca Berrens

@RBerrens

7 years

It is finally out: EndosiRNAs 'trap' #transposons during global demethylation in ESCs @CellStemCell @ReikLab

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Rebecca Berrens

@RBerrens

4 years

Are you interested in #Transposons and what to join the #TransposonWorldwide slack channel please use the following link which should not expire!

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Rebecca Berrens

@RBerrens

4 years

@wendy_bickmore I am sure a lot of postdocs would be happy to help out. Because I never say no to reviews as an early career researcher.

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Rebecca Berrens

@RBerrens

10 months

@wellcometrust @UniofOxford Also let's normalise success. There was definitely quite a few unsuccessful group leader positions I applied to before I managed to secure this grant.

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Rebecca Berrens

@RBerrens

3 years

Really cool study using @nanopore sequencing to find de novo #transposon insertions in drosophila somatic tissue finding that TE expression levels do not predict their mobility.

Kasia Siudeja

@KSiudeja

3 years

OK, here we go... online today in @embojournal . I'm really happy to share our work revealing genome-wide somatic transposition in the Drosophila gut.

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Rebecca Berrens

@RBerrens

4 years

Very happy about the outcome of this fruitful collaboration with the @CarrollDonal lab. Here we identified SPOCD1 as a novel player linking MIWI2 to de novo methylation to control especially young #transposons -L1 and IAP - in foetal testis without the production of piRNAs.

Donal O'Carroll

@CarrollDonal

4 years

Our new paper on piRNA-directed DNA methylation is out. We defined MIWI2’s interactome in foetal testis and identify SPOCD1 that links MIWI2 to the de novo methylation machinery. More to come shortly!

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Rebecca Berrens

@RBerrens

6 years

Looking forward to present our new work on single cell long read RNA sequencing for #transposon expression. Hope for some great discussions at the #transposon symposium at @UU_University

Alexander Suh 서상재

@alexander_suh

6 years

The schedule of the 2nd Uppsala #Transposon Symposium is finally online! Speakers selected from abstracts are @lmayela_soto @Hulk_Vogan @mcstitzer @SimoneFouche @RBerrens @JullienFlynn @Dreadin88 & Matt Webster See you all soon!

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Rebecca Berrens

@RBerrens

3 months

Very much looking forward to welcoming Geoff Faulkner @Faulkner_Lab @QldBrainInst to talk about LINE1 escapees to @IdrmOxford on 15th April 12 noon-1 pm.

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Rebecca Berrens

@RBerrens

3 years

#ScienceTwitter #conference organizers, can we please learn from the #cosyne21 poster session? They managed to use a virtual environment for their poster sessions. Your avatar can walk around bump into others and look at posters. Closest to real-life yet! 🤩

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Rebecca Berrens

@RBerrens

4 months

@ElowitzLab It is very similar to our igem project from 2010. As a group of 20 undergraduates we came up with this project and made a Mirna based tuned knockdown called mituner and delivered with evolution optimised aav to specific cells in Vivo

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Rebecca Berrens

@RBerrens

5 years

I'm very excited to be speaking @NanoporeConf London Calling 2019 #nanoporeconf

Oxford Nanopore Events

@NanoporeConf

5 years

We've already got some excellent speakers confirmed for London Calling 2019. Find out more, view the preliminary agenda and buy your ticket here: #nanoporeconf @NicolaHsci @khmiga @NatalieAnneRing @RBerrens @Robert_S_James

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Rebecca Berrens

@RBerrens

1 year

Very happy to have Cedric today @IdrmOxford . Cedric will share his recent exciting work on transposons in vertebrate development. Knowing his work I really hope he can help us make #Oxford #transposon addicted!

Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

Hello @UniofOxford friends! I know this is late notice but I’ll be giving a talk tomorrow Friday April 21st 3 pm @IdrmOxford , hosted by @RBerrens with happy hour to follow! 🍻

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Rebecca Berrens

@RBerrens

6 years

Just landing and super excited to discuss #transposons in the next couple of days at #UppTransposon2018 .

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Rebecca Berrens

@RBerrens

5 years

Today we are initiating the #transposon network meeting with 2 excellent speakers: Helen Rowe from @ucl and Noah Kessler from @GeneticsCam . We will also have a small breakout session about "Epigenetics to tame TEs?". Department of Genetics Cambridge at 4pm in the Part II room.

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Rebecca Berrens

@RBerrens

4 years

#transposons and DNA #methylation in one paper - must like! Very similar reprogramming to mammalian in zebra fish with Dnmt3b as maintenance.

Ozren Bogdanovic

@bogdanoviclab

4 years

Our latest work is out in @NAR_Open This exciting project was led by the very talented @Sam2Ross who uncovered a novel non-CG DNA (mCH) methylation signature that is highly abundant at zebrafish MOsaic SATellite repeats (MOSAT) in 🐟 1/4

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Rebecca Berrens

@RBerrens

2 years

It is unfortunate if people cite the information of your paper wrong. CELLO-seq is only reliant on long read sequencing data and not a combination of short and long reads to study #transposons at unique loci. Let's keep the information of the literature intact #scitwitter .

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Rebecca Berrens

@RBerrens

6 months

Fun facts of a #WomanPI - or actually just not clear #ManPI - when you have a neutral lab name like #transposon group, most people assume the one man in your groups is the group leader...

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Rebecca Berrens

@RBerrens

3 years

Amazing work by @rachellcosby from the @CedricFeschotte lab! It is very nice to see this finally in print!

Rachel Cosby

@rachellcosby

3 years

And here it is in print! So excited to see this finally out! If you missed this the first time, transpose on over to @ScienceMagazine to learn more about how transposases contribute to exon shuffling and birth of TFs & their regulatory networks

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Rebecca Berrens

@RBerrens

3 years

For a lay summary of our new method to study #transposableelement expression with long read sequencing in single cells please read this post

Gates Cambridge

@Gates_Cambridge

3 years

A study led by @RBerrens looks at a new method for studying the role of transposable elements in genetic information - @GatesAlumni @Cambridge_Uni @Trinity1546 @Cambridge_SBS

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Rebecca Berrens

@RBerrens

5 years

Really excited to hear @DrPoppyGould speaking about KZFPs to understand TE cooption. Glad you are also working on #transposons now @LabRowe lab. #MobileDNA2019

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Rebecca Berrens

@RBerrens

1 year

Amazing work from @Rowelab and specificially Rocio and @DrPoppyGould on how #transposons gain beneficial roles in development & immunity

RoweLab

@LabRowe

1 year

Excited this is out in @CellReports : Rocio Enriquez-Gasca & @DrPoppyGould shed light on how endogenous retroviruses gain beneficial roles in development & immunity, and why retrotransposons can jump in cancers, once epigenetic regulation is compromised:

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Rebecca Berrens

@RBerrens

4 years

Finally, read this really exciting preprint from @JakobssonLab which describes a brain-specific co-option of a #transposon -controlling KRAB-ZFP and how a human-specific regulatory network is established by a cis-acting structural genome variation

A human-specific structural variation at the ZNF558 locus controls a gene regulatory network during...

The human forebrain has expanded in size and complexity compared to that of chimpanzee despite limited changes in protein-coding genes, suggesting that gene regulation is an important driver of brain...

www.biorxiv.org

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Rebecca Berrens

@RBerrens

6 years

@AliciaOshlack I personally don't like to apply for women only awards as I want to be seen as a scientist and in my opinion a women only award will just underline that women cannot compete with men in the awards so need a separate one which is the wrong message in my view.

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Rebecca Berrens

@RBerrens

5 years

Today is #transposon network meeting at 4pm in @GeneticsCam partII room. Monique Merchant will present on #ERVs in nematodes and I will present on @nanopore single cell sequencing. Please join and bring change for beer and vine during discussion session. In need of #sponsors !

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Rebecca Berrens

@RBerrens

4 years

Using long-read technologies (nanpore/pacbio) to sequence SVs at low depths. You can definitely find #transposons

NanoVar: accurate characterization of patients’ genomic structural variants using low-depth...

The recent advent of third-generation sequencing technologies brings promise for better characterization of genomic structural variants by virtue of having longer reads. However, long-read applicat...

genomebiology.biomedcentral.com

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Rebecca Berrens

@RBerrens

7 years

Nice summary of our study on #endosirnas as traps of #transposons @ReikLab @BabrahamInst @epigenie

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Rebecca Berrens

@RBerrens

4 years

Really amazing work by Dr.Lisa Rodermund and my colleagues @BrockdorffLab using their new method RNA-SPLIT to uncover kinetics of Xist RNA spreading.

Brockdorff Lab

@BrockdorffLab

4 years

Check out our latest preprint: We have developed an exciting new technique, RNA-SPLIT, which combines HaloTag labelling with 3D-SIM, to elucidate key principles of Xist RNA localisation, kinetics and spreading: 1/4

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Rebecca Berrens

@RBerrens

5 years

More TE expression in single cells by reanalysing existing datasets, interestingly analysed using Repbase. Expression dynamics of repetitive DNA in early human embryonic development. #singlecells #transposons

Expression dynamics of repetitive DNA in early human embryonic development - BMC Genomics

Background The last decade witnessed a number of genome-wide studies on human pre-implantation, which mostly focused on genes and provided only limited information on repeats, excluding the satelli...

bmcgenomics.biomedcentral.com

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Rebecca Berrens

@RBerrens

5 years

I had a great #skypeascientist session talking about #genetics with the class of Caroline Bowman from Mainland Regional High School. Very interesting questions about the ethics of #CRISPR and the use of genetics for health testing and most importantly #transposons !

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Rebecca Berrens

@RBerrens

4 years

#CELLO -seq is a template switching scRNA-seq method with UMIs being added with splint ligation to each transcript. PCR duplicates are used to error correct @nanopore sequencing reads using our computational framework (, ). 4/n

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Rebecca Berrens

@RBerrens

5 years

I am #running my FIRST ever #halfmarathon in #Oxford raising money for #Alzheimers Society and any support is appreciated. Please give money for this charitable cause to support #research

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Rebecca Berrens

@RBerrens

6 months

I regularly get asked how my PI is and today my research assistant got asked whether there is a Job in his lab...

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Rebecca Berrens

@RBerrens

5 years

It's great that more people are thinking about methods how to properly quantify Line1 expression. Will need to look at this new method. Very important also with regard to #longreads and #singlecell expression analysis...

Gael Cristofari

@retrogenomics

5 years

Exciting new efforts and strategies to estimate LINE-1 retrotransposon expression and to solve the issues of pervasive transcription and/or multi mapping reads: TeXP by @FNavarroBioInfo and L1EM by @CompProteomics

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Rebecca Berrens

@RBerrens

5 years

Really interesting and comprehensive review on Transposable elements and DNA methylation in the genome. A lot of work ahead for the field but really exciting times. Thank you @BrancoLab !

Miguel Branco

@BrancoLab

5 years

Our @NatureRevGenet review is out ! The authors are three, but the key contributors go well beyond, including R. Meehan, M. Lorincz, reviewers (J. Dejardin, M. Gauchier, J. Pontis, D. Trono and others), and editor Darren Burgess. Many thanks to all!

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Rebecca Berrens

@RBerrens

5 years

@MollyHammell @manvendr7 I created a Worldwide TE channel:

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Rebecca Berrens

@RBerrens

5 years

Out first Tansposon Network meeting is taking place today at 4pm in Genetics, Bateson room. We will do a small intro round and dive into discussions before deciding on the format for following meetings - really excited for today!

Rebecca Berrens

@RBerrens

5 years

Are you studying transposons? Would you like to get connected with other people in #Cambridge who study #transposons ? We are trying to generate a “Transposon Network Cambridge”. Please PM me if you are interested so we can setup a slack and gather interest for monthly meetings.

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Rebecca Berrens

@RBerrens

7 years

Exciting: first time being part of a preprint on biases in whole-genome bisulfite sequencing library preparation strategies affecting DNA methylation data with @Reiklab @BrancoLab @BabrahamInst

Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources...

Background Whole-genome bisulfite sequencing (WGBS) is becoming an increasingly accessible technique, used widely for both fundamental and disease-oriented research. Library preparation methods...

www.biorxiv.org

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Rebecca Berrens

@RBerrens

4 years

It has been a long time that I emerged myself into the world of RNAs by attending #RNA2020 . I was blown away by the breadth of research and leave this meeting with loads of food for thought! THANK YOU so much for sharing your work everyone!

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Rebecca Berrens

@RBerrens

3 years

Really great story on how m6A methylation degrades ERVK mRNAs to control #transposons ! Congratulations @DeborahBourchis , @TChelmicki and team!

Deborah Bourc’his

@DeborahBourchis

3 years

⁦ @TChelmicki ⁩ and I are thrilled to share with you a novel means of retrotransposon control, specific to ERVKs. When 5mC DNA methylation fails, m6A RNA methylation can degrade activated ERVK mRNAs. 1/n

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Rebecca Berrens

@RBerrens

4 years

Great work by the @PaulFlicek 's lab on "opposing contributions of LINE L1s and L2s to regulatory evolution. [...] active LINEs do not generally arise from lineage-specific insertions, [...] predominant mechanisms for regulatory activation is mutation of ancient elements"

Mobile DNA

@MobDNAjournal

4 years

LINE elements are a reservoir of regulatory potential in mammalian genomes #transposon

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Rebecca Berrens

@RBerrens

5 years

@alex_ander Should one give up even trying to go further if that already happens as a postdoc?

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Rebecca Berrens

@RBerrens

6 years

Shout out for active #transposons from Hans Jansen at #nanoporeconf in the tulip genome which is 34Gbp big.

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Rebecca Berrens

@RBerrens

5 years

Our next TE network meeting will be on 17th of June at 4pm in the #Genetics department Part II room. We will have Marta Seczynska (Lehner Lab) and Cristian Riccio (Miska & Hemberg Lab) presenting. Discussion will be on: "Which seq method do you use to study #transposons ?"

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Rebecca Berrens

@RBerrens

4 years

TEX15 is another player involved in #piRNA and #transposon #methylation in mammals. It is always fun to collaborate on interesting research @CarrollDonal

Donal O'Carroll

@CarrollDonal

4 years

Interested in piRNAs and transposon methylation? Our new paper introduces TEX15 as an interactor of MIWI2 and reveals an essential role in the execution of piRNA-directed DNA methylation.

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Rebecca Berrens

@RBerrens

5 years

I am running my first ever half marathon for @alzheimerssoc . Please help me support #research into this neurodegenerative #disease :

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Rebecca Berrens

@RBerrens

8 years

#Transposon derived #piRNAs in #epigenetic reprogramming in vitro PGCs development @Dev_Cell @ReikLab … … …

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Rebecca Berrens

@RBerrens

5 years

Our next #transposon network Cambridge meeting is taking place today at 4pm @GeneticsCam . We have Yorgo Modis and Anna Protasio presenting and will have discussion with drinks and pizza kindly sponsored by NEB.

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Rebecca Berrens

@RBerrens

5 years

It was great fun to be teaching methylation analysis to the #EMBL couse on enzymatic methylation sequencing together with @NEB and the Genomics Core at EMBL.

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Rebecca Berrens

@RBerrens

5 years

Please everyone join the worldwide #transposon slack channel. Invitation link: #MobileDNA2019

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Rebecca Berrens

@RBerrens

1 year

Well done @ArminLak , very proud of you!

DPAG Athena SWAN

@DPAGAthenaSwan

1 year

Congratulations to @ArminLak appointed Associate Professor of Integrative Neuroscience in DPAG @OxfordMedSci & @StJohnsOx

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Rebecca Berrens

@RBerrens

3 years

A belated happy #transposonday everyone. If you want to take part in our online community please join the #transposonsworldwide slack channel . Please also check out the amazing new resource

The Nobel Prize

@NobelPrize

3 years

Barbara McClintock is the only woman to be awarded an unshared #NobelPrize in Physiology or Medicine. McClintock discovered 'jumping genes' in corn, and proved that chunks of genetic code can change position on a chromosome, affecting genetic expression. #NobelPrize

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Rebecca Berrens

@RBerrens

7 years

Amazing potential for fieldwork applications. So exciting! @nanopore @miniPCR

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Rebecca Berrens

@RBerrens

6 years

Come check out our method on single cell full-length cDNA sequencing with UMIs for error correction at Poster 32 16.10-16.50 today. #nanoporeconf

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Rebecca Berrens

@RBerrens

4 months

This is very cool, also a topic we got to during our iGEM project back in 2010 using miRNA binding sites called miTuner :) Really cool that someone else found this very important.

Lappalainen Lab

@tuuliel_lab

4 months

We know the importance of subtle gene dosage variation, and yet the main tool of molbio is gene KO/KD. In our new preprint, @JuliaDiumenge introduced subtle modulations of transcription factor dosage by CRISPRi/a, and quantified responses by scRNA-seq. 1/

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Rebecca Berrens

@RBerrens

1 year

Yesterday was the "last" Dining with Dinosaurs @ReubenCollege . We will keep the name for our future dinners and also will come back to @morethanadodo once a term. We were so lucky to see one of the last Dodo bones yesterday!!

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Rebecca Berrens

@RBerrens

5 years

So cool - Inflate your embryo via @the_Node

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Rebecca Berrens

@RBerrens

4 years

Exploring the relationship between the expression of individual elements and putative regulators revealed surprising heterogeneity, with TEs within a class showing different patterns of correlation, suggesting distinct regulatory mechanisms. 11/n

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Rebecca Berrens

@RBerrens

3 years

Thanks to our funders @wellcometrust @embl and @CRUK CELLO-seq is now available for everyone to use. We would also like to thank the reviewers @Faulkner_lab the 3 anonymous reviewers as well as the editors at @NatureBiotech for their support and suggestions. 4/n

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Rebecca Berrens

@RBerrens

5 years

@CedricFeschotte Thank you. It's exciting times of @nanopore sequencing and I am always happy for interesting collaborations on interesting samples using this method.

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Rebecca Berrens

@RBerrens

5 years

@manvendr7 Maybe we can organise another slack channel for European #transposon community or worldwide #transposon community? This one is supposed to be for getting Cambridge people connected and find synergies

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Rebecca Berrens

@RBerrens

2 years

Please join us and learn about all the new technologies and research in #transposons at the Winter school on Transposable elements in Paris!

Deborah Bourc’his

@DeborahBourchis

2 years

Hello TE afficionados! We organize a Winter School on Transposable element bioinformatics in Paris, Feb6-10 2023. Initiated by Vincent Colot, with @LabRowe @FelipeKTeixeira @retrogenomics @GonzalezLab_BCN @MobileGenomes @RBerrens @leandroquadrana and me!👇

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Rebecca Berrens

@RBerrens

5 months

It was my honour to write the @ReubenCollege blog for this exciting Dining with Dinosaurs event with Nobel Prize winner Sir Peter Ratcliffe. Thank you @McKeatingLab for hosting!

Reuben College, Oxford

@ReubenCollege

5 months

Sir Peter Ratcliffe, Nobel Prize winner for medicine, recently visited Reuben College. Read all about the talk he gave while with us here: #reubenevents #reubencollege

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Rebecca Berrens

@RBerrens

5 months

Very happy to have played a small part in this publication by the Donal O'Carroll group!

Department of Paediatrics

@OxPaediatrics

5 months

New research by our Principal Investigator @RBerrens and published in @MolecularCell sheds light on complexity of genetic regulation

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Rebecca Berrens

@RBerrens

3 years

Congratulations @JakobssonLab for publishing this really cool study on endogenous retrovirus expression during brain development resulting in neuroinflammation. Read the tweetorial for more information!

Johan Jakobsson

@JakobssonLab

3 years

🔥I am very proud that our most recent paper is now out in @embojournal 🔥 A fantastic multi-year team effort led by @crocheholic ! @Lund_Stem @medfak_LU @Lundsuni 1/9

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Rebecca Berrens

@RBerrens

3 years

Finally, please see the preprint thread for a little more detail on the CELLO-seq and the biological contexts in which we explored it. 5/5.

Rebecca Berrens

@RBerrens

4 years

Very happy to share our latest preprint describing our new method single CELl LOng read sequencing (CELLO-seq) for full-length #allelic , #isoform and #TransposableElement (TE) expression at unique loci resolution 1/n

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Rebecca Berrens

@RBerrens

6 years

Thank you all for tweeting about. #cshlTE18 . Very bumped to miss it but hopefully the next grant will allow me to join the following years :)

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Rebecca Berrens

@RBerrens

1 year

Congratulations @AleksSzczurek and the rest of the @RobKlose lan! Nice to see this study finally out. Transcription at single molecule level in live cells understanding polycomb!

Aleksander Szczurek

@AleksSzczurek

1 year

1/6 I'm pleased to announce new preprint on how Polycomb system controls transcription in living cells by myself, @RobKlose , @emmy_dimitrova , and @Jess_R_Kelley

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Rebecca Berrens

@RBerrens

4 years

@MollyHammell I think this is my favourite solution so far! Well done @alexander_suh and @ClaudiaKutter

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Rebecca Berrens

@RBerrens

3 months

Really cool story. Amazing that it is a non-coding RNA!!! Well done to the team effort!

Nicky Whiffin

@nickywhiffin

3 months

Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9

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Rebecca Berrens

@RBerrens

5 years

#embomzt in action: light to dark beer transition #mzt -> #ldt

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Rebecca Berrens

@RBerrens

1 year

This is another system where we see a hierarchical or dependence of transposon upregulation on several epigenetic regulators. Very nice dissection and system!

Johan Jakobsson

@JakobssonLab

1 year

New transposon preprint! We are extremely excited about this collaborative work led by the @ch_douse lab. A mechanistic dissection of the interaction between DNA-methylation and HUSH in the control of LINE-1s in human somatic cells. Such a cool system…🧬

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Rebecca Berrens

@RBerrens

10 months

@ArminLak Thank you! Not possible without your support! There are some benefits of a partner in crime in science!

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Rebecca Berrens

@RBerrens

3 years

It also incorporates a method on how to study #transposon subfamily expression at #SingleCell level by @MollyHammell lab.

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Rebecca Berrens

@RBerrens

3 years

I'm extremely grateful to the amazing people involved in this project @MarioniLab , @_andrianyang , @tendersombrero , Aaron Lun, @flobdalabob , Guocheng Lan, Cheuk-Ting Law, Maria Imaz, @danjgaffney , @BrockdorffLab , @_joebowness for their hard work and excellent advice! 2/n

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Rebecca Berrens

@RBerrens

6 years

Great computational method to #unmask #transposons !!!

Guillaume Bourque

@guilbourque

6 years

Computational Tools to Unmask Transposable Elements. Our @NatureRevGenet review is finally out! Huge effort by my student @PatGoerner who did incredible work. Apologies to colleagues whose tools we couldn't cover.

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