Cedric🧬➰🧬Feschotte @CedricFeschotte Twitter profile

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

Latest update to our lab website 😍😻😍

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

CRISPR is amazing

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

When PI goes back to the bench to show how it’s done

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

Supportive senior author adding their “magic touch”

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

Dreams do come true! I am now the Barbara McClintock Professor of Molecular Biology and Genetics!!! 🍾 Incredibly honored & uplifted to adorn my title with the name of my scientific hero. 🥹 I owe it to all who have supported me: colleagues, mentors, mentees, friends, family. 🙏

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

🐙 ALERT! So when you put an octopus in cold water it recodes 13,000 codons (1/3 of all recoding sites!) via massive RNA editing in the brain!! And this apparently alters the function of synaptic proteins! 🤯🤯🤯 That’s insane (but not for the octopus)

Temperature-dependent RNA editing in octopus extensively recodes the neural proteome

Octopuses utilize RNA editing to rapidly respond to environmental temperature changes by altering protein function.

www.cell.com

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

💥It's published! 🎉 Recurrent evolution of vertebrate transcription factors by transposase capture 6+ years in the making! The story in a nutshell 🧵1/n

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

CRISPR is amazing

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

When the PI shows how it’s done

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

💥Our new paper just out @ScienceMagazine ! Antiviral activity of a human protein of retroviral origin A study led fearlessly by @jofrank1088 We propose that the human genome encodes a deep pool of antiviral proteins derived from retroviruses!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

This beauty has a genome 10 times bigger than you

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Research, 99% of the time

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

After 20 years as an alien, today I became a citizen of the United States of America! 🇺🇸

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

5 years

Randy Schekman unveils new journal “denature” 😭😭😭

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

CRISPR changed everything

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

When you try to keep up with the literature

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Awaiting Reviewer Assignment

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

ONT, Illumina, Pacbio, Sanger

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Abstract vs Actual Results

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

This cutie is the Antarctic krill. Its genome is 48 Gb, 15x the human genome! 92% repeats! CMC/CACTA elements, an enigmatic and relatively rare group of DNA transposons in other animals, alone account for 42%!! Why these and why in krill?…🤔😯🤯

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

When you stumble on a video of your own talk

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

First and corresponding author

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

When you watch your own talk

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Us when the genome is made publicly available

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

7 months

“Transposable elements contribute to nearly 80% of human-specific candidate cis-regulatory elements in cortical cells” 🧠 …🤯 literally! Amazing dataset 🔥 Congrats to all involved!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

6 years

Geek out!! The original corn ears that led Barbara McClintock to the discovery of transposons. Complete with handwritten tags #cshlTE18

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

. @OdedRechavi for a physiologically if not royally relevant keynote at #EMBOepigenome

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

On this #InternationalWomensDay I salute all the women studying #transposons , carrying the torch lit by Barbara McClintock, who remains the only woman awarded an unshared Nobel prize in physiology or medicine, for her discovery of mobile genetic elements. #IWD23 #WomenInSTEM

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 months

💥Our new preprint! Transposon ADDICTION in development! Gag proteins of endogenous retroviruses are required for zebrafish development Study led heroically by @sylviaandbu & @JN_Wells This work has transformed my view of transposons, no less! 🧵1/n

Gag proteins encoded by endogenous retroviruses are required for zebrafish development

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. The process by which TEs become coopted remains...

www.biorxiv.org

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

When you write your own recommendation letter

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

10 months

Barbara McClintock is my idol so I was stoked to write this piece commemorating the 40-year anniversary of her Nobel Prize for the discovery of mobile genetic elements. What a legacy! Still so much we need to understand about these most fascinating elements!

Nature Reviews Genetics

@NatureRevGenet

10 months

Transposable elements: McClintock’s legacy revisited #Perspective #Essay by @cedricfeschotte

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

6 years

I printed mine on toilet paper. It was super useful at first but now it's gone.

Grace Lindsay

@neurograce

6 years

I said I'd do it and I did. I got my thesis printed on a scarf.

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

Teaser! ...from our upcoming @AnnualReviews with @JN_Wells (😍 his art) A Field Guide to Eukaryotic Transposable Elements

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

The committee unanimously recommended promotion and tenure

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

omg the views from @cornell today 😍🍁🍂🎃

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

Sad to hear of the passing of Haig Kazazian, a giant in the field of human genetics. After identifying a LINE1 insertion causing hemophilia, his lab trail-blazed 30+ yrs of key discoveries on human transposons. An amazing career he narrated here:

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

The data presented in this preprint are unconvincing and insufficient to claim SARS-CoV-2 is reverse-transcribed and integrated in the human genome. Many have already pointed out the flaws, but here is a summary. 1/n

bioRxiv Genomics

@biorxiv_genomic

4 years

SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome #biorxiv_genomic

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Woohoo💥we have TWO new NIH-funded projects on human endogenous retroviruses and HIV! Both are part of exciting international collaborations. If you’re looking for a postdoc or tech position in this area, do reach out! Or RT & spread the word 🙏✖️💯

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

10 months

💥Excited to unleash ENCOTE: Encyclopedia of Transposable Elements with cis-regulatory activity in the human genome! Collab w @twang5 for #ENCODE led by🔥trio Alan Du, Jason Chobirko & @XiaoyuZhuo TEs = 25% of all cCREs = 200,000+ elements!! Deep dive! 1/n

Regulatory Transposable Elements in the Encyclopedia of DNA Elements

Transposable elements (TEs) make up about half of the human genome and many have the biochemical hallmarks of tissue- or cell type-specific cis -regulatory elements. While some TEs have been rigoro...

www.biorxiv.org

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

5 years

Greatly honored to join this group of scientists, alongside some who have influenced me for many many years. Thanks to all of my mentors AND my trainees with whom I share the honor☺️

AAAS

@aaas

5 years

Congratulations to the newly elected 2019 AAAS Fellows!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

I have a transposon joke but it’s kinda repetitive.

Alyssa Emig

@AlyssaEmig

1 year

Thought of an embryo joke but it never fully developed.

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Live footage of PI making a return at the bench

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

When reviewer ask to validate RNA-seq by qRT-PCR

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

When the PI adds a personal touch to the experiment

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 months

A genetic element aka a transposable element. Just say it ffs!! 😜🐒

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

Can't resist sharing this fig preview of an upcoming review on transposons & gene reg @judd_julius and I had great fun writing with @FueyoRaquel & Joanna Wysocka. Seeing these proofs put a big smile on my face! #ThursdayTease

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

Me after the first three weeks of semester

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Co-senior authors

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Supplemental data for Nature paper

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

Our new review on Transposons & Gene Regulation is out! A huge treat to write with @FueyoRaquel @judd_julius & Joanna Wysocka 🙌🥂

Julius Judd

@judd_julius

2 years

Super excited to share this review that I wrote with @FueyoRaquel @CedricFeschotte and Joanna Wysocka!! This was a lot of fun to write and I hope you all enjoy it!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

PI: “okay, but did you replicate the results?”

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

5 years

I started a list of 100+ #WomenInScience running an active lab and recently studying #transposons or #repetitiveDNA . RT & help grow the list! 1/n #WomenInSTEM #McClintockDay #TransposonDay2019

Women_PI_TEs_list_created_by_CedricFeschotte_June2019

Sheet1 Last Name,First Name,Affiliation,Country,Primary Focus,Primary Model,Junior PI? (>=5 yr),Website,Twitter handle Aktas,Tugce,Max Planck Institute for Molecular Genetics, Berlin,Germany,Evolut...

docs.google.com

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

Today I aced my 🇺🇸citizenship interview! Cosmo celebration!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 month

The Feschotte Lab turns 20!🎂❣️🍾 Extra special to reunite with alum and celebrate all who have gotten us there: mentors, mentees, colleagues, friends, and of course my loving family🥰 🫶

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

8 years

Geek out: original maize ears used by McClintock to discover #transposons . Complete With her handwritten tags!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

When the data reject your hypothesis but you won’t admit it

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

If that’s what’s meant by groundbreaking research, then yes, all the time

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

Wow Fall, just wow.

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

6 years

Never too early to celebrate transposon day!! June 16, birthday of Barbara McClintock #transposonday2018

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

When the PI insists on giving a hand to organize the lab

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

. @cornell campus today just wow 😍❄️🌞

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

How a resident retrovirus sneaks through the human embryo! 🧨💥 Now out in @eLife ! Work brilliantly led by @LordLump w. super squad @manvendr7 @Gabrijela_D @Noncodarnia & Jason Chobirko. Find out why we're excited about it! 🧵👇Kinda wild!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

6 years

10 Things You Should Know About #Transposons A collective piece emerged from brainstorming with a fantastic bunch... 1/n

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Late to it, but this story of sex chromosome evolution in the creeping vole is ABSOLUTELY WILD! 🤯🤯🤯 Y was lost and replaced by male-determining X! Part of Y moved to X so females express ancestral male-spe genes and X is inactivated in male soma!!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 months

Somethin’ else: celebration time! 🥂Honored + grateful to receive this award from @CornellCALS today. THANKS to those who put forth and supported my nomination, to mentors and mentees, and to my family for making it all possible. This is dedicated to y’all 🥹🥰

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Can we just now all agree that transposons are the head or tail of EVERYTHING

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

When it’s your turn to edit the manuscript

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

Our latest review, led masterfully by @JN_Wells

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Happy #TransposonDay2021 ! Happy b-day Barbara! To celebrate the lab took a pilgrimage to McClintock shed on our beautiful @cornell campus!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

Why some animals can regrow a limb but others like humans can't? Krista Angileri brings expertise & creativity to develop the hypothesis that transposon control is key to tissue regeneration - with help from💎undergrad, Nornu Bagia @Dev_journal 🧵1/n

Transposon control as a checkpoint for tissue regeneration

Summary: This Hypothesis argues that the process of tissue regeneration is conducive to transposable element activities that, if left uncontrolled, create an insurmountable barrier to tissue repair.

journals.biologists.com

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

@McKnightLab_UO Jeff, you don’t know me but I’ve been thinking about you all day. On my way back home this evening I stopped to take this photo because the colors brought some inner peace. I am heartbroken tonight but forever inspired by your courage, strength, and honesty.

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

29 days

Huge loss for science. RIP Mary-Lou Pardue, one of my heroes. Many groundbreaking contributions including: 🧬 in situ hybridization 🪰 Drosophila uses retrotransposons instead of telomerase to cap chromosomes ✊ spearheaded fight against discrimination of women faculty at MIT

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

Happy #TransposonDay2023 y’all! Celebrate the visionary and deeply influential work of Barbara McClintock with a few delicacies we owe to transposons 🍷🧀🍊🍹as wisely recommended by @MollyHammell :

Mobile DNA

@MobDNAjournal

1 year

Happy Transposon Day 2023! Today is the 121st birthday of Barbara McClintock, founder of the #transposon field and Nobel laureate. Please celebrate with us by using the hashtag #TransposonDay2023 . How has Barbara McClintock or her work influenced you?

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

When you realize your talk must be cut by half

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Experimental design, 99% of the time

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

PI trying to sell yet another new project to grad student

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

I ❤️ GIANT GENOMES @profaxelmeyer : lungfish genome is 14x larger than human and keeps on growing via transposition. 90% repeats! Just in past few million years LINE expansion resulted in DNA gain equivalent to an entire human genome! 🤯 Where’s the limit? #EMBOEvolAnimalGenomes

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

When the data tell you the exact opposite of your hypothesis

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

We believe in a spirited yet collaborative environment

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Another gorge-ous day in Ithaca

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Got a nice birthday present! 💉💕🎉

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

ACCEPTED!🍾🍾🍾 Merry Xmas @rachellcosby et al! 🎁🎄🙏

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

Welcome to the wild world of transposons! Mavericks viral-like elements captured and transferred genes across 🪱 species. One transferred gene then evolved into toxin-antitoxin system carried by yet another transposon! Very cool work by @arburga et al!

Virus-like transposons cross the species barrier and drive the evolution of genetic incompatibili...

Mavericks, virus-like transposons, gained a fusogen in nematodes and became a recurrent vector of horizontal gene transfer.

www.science.org

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

CRISPR is amazing

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

1 year

Immensely proud of @sylviaandbu who defended her PhD today with typical brilliance, energy and joy! Congrats Dr. Chang!! Her work has transformed the way I think of transposons! 🥹🍾👏

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

I am away from my desk and will reply to your email as soon as I return

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Research, 1% of the time

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

On this #TransposonDay2022 , I am returning to this wonderful bio of #BarbaraMcClintock by Evelyn Fox Keller. Barbara is a perpetual source of awe and inspiration! Yet her impact remains grossly under appreciated 🧵1/n

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

How swimming pools look like in Ithaca 😍

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

8 months

I VOTED! ✔️🗳️ First time as an American!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

Beyond thrilled to unveil our latest preprint! 🧨💥 Birth of transcription factors via transposase capture An epic led masterfully by @rachellcosby . 6 yrs of work boiled down in one thread👇

Rachel Cosby

@rachellcosby

4 years

Ever wonder where new genes come from? In this preprint we 1) characterize transposase capture, an evolutionary process promoting gene birth from DNA TEs, 2) determine principles of how this occurs, and 3) that many are transcriptional regulators 1/12

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

y’all be amazed of what the PI can do when making a comeback to the bench

Luc Roberts

@ScienceLuc

4 years

Bad stock photo or innovative new method? #science #pipette

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

When two lab members tie the knot in Ithaca 🥰💕Congratulations @sylviaandbu & @JN_Wells ! So so so happy for you!!!

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

3 years

Me every time I overthink it

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

4 years

I am deeply honored to be running for President of @OfficialSMBE this year. I am still pinching myself to see my name on the ballot alongside others I admire. Members, cast your vote by June 26! My candidacy statement 👇

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

💥our latest preprint is out! 750 million years of coevolution between Transposable Elements and Zinc-Finger genes!! Brilliantly led by @HFSP fellow @JN_Wells with 🔥 team @sylviaandbu @TE_penthouse Bozhou Jin +2 terrific UGs Caitlyn Coleman & Nathalie Ramos👇 #proudPI

Jonathan Wells

@JN_Wells

2 years

Excited to finally be able to share some new work on the evolution of zinc finger genes! Zinc finger genes are a deeply conserved family of eukaryotic transcription factors. But in animals, the copy number of these genes has exploded 💥 (1/10)

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Cedric🧬➰🧬Feschotte

@CedricFeschotte

2 years

Our 1st paper on #zebrafish #transposons now out at @genomeresearch ! Wonderful collab w @Vaquerizas_lab co-led by @sylviaandbu @quirze92 @JN_Wells 🙏prodigious effort prior & thru pandemic! THX to reviewers who help improve upon preprint unpacked👇🧵

Vaquerizas Lab

@vaquerizas_lab

3 years

We’re delighted to share our latest work in collaboration with @CedricFeschotte ‘s lab on #TransposableElements in #zebrafish development! @vaquerizasjm @MRC_LMS @MPI_Muenster Find out more in the @biorxivpreprint Summary below 👇 1/9

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