Mullally Lab @MullallyLab Twitter profile | Pikagi

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Mullally Lab

@MullallyLab

2,423

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Heme Chief @StanfordDeptMed Physician-Scientist #bloodcancers #MPNsm @VAPaloAlto Formerly @BrighamHeme @DanaFarber @OslerResidency @UCDMedicine views my own

Palo Alto, CA

https://t.co/ykDrfJTGup

Joined February 2018

Don't wanna be here? Send us removal request.

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@MullallyLab

Mullally Lab

7 months

Thrilled to share that I've been appointed Chief of Hematology @StanfordDeptMed starting May 2024! Honored to take over this role from the phenomenal Dr. Bev Mitchell & to follow distinguished prior Chairs: Drs. Ravi Majeti @majetiLab , Linda Boxer, Larry Leung & Stan Schrier. /1

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@MullallyLab

Mullally Lab

4 years

Thrilled to share our JAK2 paper out now @CellStemCell ! @SahandHormoz @isidrolauscher @BrighamHeme @DanaFarber @emblebi #MPNsm Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms

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Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in...

Van Egeren et al. investigated the effect of the JAK2-V617F mutation in individuals with myeloproliferative neoplasms (MPNs) using single-cell profiling and found that the mutation occurs decades...

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@MullallyLab

Mullally Lab

2 years

Thrilled to share our latest paper out now @BloodJournal : Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs

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Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability...

Calreticulin (CALR) mutations are important disease-initiating drivers of myeloproliferative neoplasms (MPNs) and cause hyperproliferation by binding to th

ashpublications.org

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@MullallyLab

Mullally Lab

3 years

Our latest paper is out in First Ed @BloodAdvances ! Genomic Profiling of a Randomized Trial of Interferon-α versus Hydroxyurea in MPN Reveals Mutation-Specific Responses | Blood Advances | American Society of Hematology

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@MullallyLab

Mullally Lab

5 months

Hello California! ☀️ Excited to start next week @StanfordDeptMed as Heme Chief @StanfordMed My lab is actively recruiting, pls DM me if interested in joining us to study #MPN in sunny California! ☀️😎

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@MullallyLab

Mullally Lab

4 years

We studied newly diagnosed patients with ET and PV, reconstructing the lineage history & differentiation trajectories of individual JAK2V617F HSC - here is our preprint will full details #MPNsm

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Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in...

Some cancers originate from a single mutation event in a single cell. For example, blood cancers known as myeloproliferative neoplasms (MPN) are thought to originate through the acquisition of a...

www.biorxiv.org

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@MullallyLab

Mullally Lab

5 months

So thankful to everyone ⁦ @StanfordHeme ⁩ for such a warm welcome today, my first day as Heme Division Chief ⁦ @StanfordDeptMed ⁩ ⁦⁩ ⁦ @StanfordMed ⁩🌹🌸 🙏

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@MullallyLab

Mullally Lab

7 months

Very excited to join @StanfordDeptMed #StanDOM , looking forward to working with everyone! @StanfordMed @StanfordHeme @StanfordMedRes

@StanfordDeptMed

Stanford Department of Medicine

@StanfordDeptMed

7 months

We're ecstatic to welcome Ann Mullally ( @MullallyLab ) to #StanDOM as a professor of medicine & the new division chief of #Hematology ! She is known as a passionate advocate for #TeamScience & #PhysicianScientists in medicine!

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@MullallyLab

Mullally Lab

6 months

Thanks to all the wonderful mentors, colleagues, trainees & admin staff I've worked with @BrighamHeme , fun party last week, I will miss you all! @vangalenlab @NTConnell @MaureenAchebe @joanhowMD @TheBianchiLab @SandraMcAllist4 @adamssperling @KoduriLab @HollenhorstM @connors_md

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@MullallyLab

Mullally Lab

6 months

A highlight of my time @BrighamHeme has been scientific interactions with Dr. Peter van Galen @vangalenlab , one of the most generous, thoughtful & forwarding thinking scientists I know. Our labs have benefited so much from our joint lab meeting! @BrighamResearch @broadinstitute

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@MullallyLab

Mullally Lab

4 years

Fedratinib in myelofibrosis | Blood Advances | American Society of Hematology. Our review is out! ⁦ @BloodAdvances ⁦ @ASH_hematology ⁩ Co-authored with ⁦ @mpdrc ⁩ ⁦ @harrisoncn1 ⁩ ⁦⁦ @PrezCamacho ⁩ #MPNsm ⁦ @BrighamHeme ⁩

Fedratinib in myelofibrosis

Abstract. Following the discovery of the JAK2V617F mutation in myeloproliferative neoplasms in 2005, fedratinib was developed as a small molecular inhibito

ashpublications.org

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@MullallyLab

Mullally Lab

2 years

Huge honor to be part of @CellStemCell top 10 for 2021! Major kudos to @SahandHormoz @isidrolauscher @DebraVanEgeren et al for applying computational "smarts" to study #mpn @DanaFarber @emblebi @harvardmed @BrighamHeme @MGHCancerCenter @BCHStemCell #MPNsm

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Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in...

Some cancers originate from a single mutation event in a single cell. Blood cancers known as myeloproliferative neoplasms (MPNs) are thought to originate when a driver mutation is acquired by a...

pubmed.ncbi.nlm.nih.gov

@CellStemCell

Cell Stem Cell

2 years

9/10 #BestofCellStemCell Sahand Hormoz & Co @harvardmed use single-cell transcriptomics and whole-genome sequencing of stem cells from individuals with MPN and found evidence that a oncogenic mutation can occur in a single HSC decades before diagnosis.

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@MullallyLab

Mullally Lab

5 years

Targeting mutant CALR in MPN! Check out our Blood Spotlight ⁩published today! ⁦ @BloodJournal ⁩ ⁦ @GabyHobbs ⁩ #MPNsm

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@MullallyLab

Mullally Lab

2 years

Is mutant CALR immunogenic? New paper @ScienceTM led by @MathieuGigoux suggests YES! Great collaboration across @MSKCancerCenter @DanaFarber @BrighamHeme @CCITdk @IcahnMountSinai @MGHCancerCenter @broadinstitute @holmstrom_mo @merghout @wolchokj #MPNsm

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Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an...

A heteroclitic CALRMUT peptide cancer vaccine strategy counters MHC-I skewing in patients with MPN.

www.science.org

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@MullallyLab

Mullally Lab

3 years

Our latest using combined scRNAseq & JAK2 genotyping to decipher transcriptional differences between JAK2-V617F and wild-type bone marrow cells @DebraVanEgeren @Baransel_Kamaz @Chris_R_Reilly @GabyHobbs @isidrolauscher @SahandHormoz @ISEHSociety #MPNsm

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@MullallyLab

Mullally Lab

5 years

Not every day ⁦ @OslerResidency ⁩ alum wins ⁦ @NobelPrize ⁩! We are inspired by Bill ⁦ @kaelin_lab ⁩ (Thayer)! With Priscilla Brastianos (Barker), Jaclyn LoPiccolo (Janeway), Julie Losman (Longcope) ⁦ @DanaFarber ⁩ ⁦ @df_hcc ⁩ ⁦ @DamonRunyon ⁩ #OslerPride

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@MullallyLab

Mullally Lab

6 months

As incoming Heme Chief @StanfordDeptMed , a high priority is expanding the outstanding @StanfordHeme faculty! We're seeking a #physicianscientist in heme malignancies; candidates with experience in clinical trials and/or translational research with lab aspect encouraged to apply!

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@MullallyLab

Mullally Lab

2 years

First in-person @MullallyLab retreat since 2019! So great to come together in the beautiful @Harvard campus to brainstorm on science, learn more about each other's backgrounds & career goals & of course enjoy lunch together - fab day! @BrighamHeme @BrighamResearch @harvardmed

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@MullallyLab

Mullally Lab

11 months

As #ASH2023 approaches, I wanted to share some @ASH_hematology abstracts from our MPN cohort @DanaFarber @BrighamHeme now comprising approx 1300 patients on whom we have comprehensive molecular genetic profiling, clinical data, labs and pathology. Three abstracts to follow #MPNsm

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@MullallyLab

Mullally Lab

4 years

Just recorded my talk for @ISEHSociety virtual meeting! Very fun! What a phenomenal program: including: @TrowbridgeLab @TheKingLab @bloodgenes @AbdelWahablab @KenFigueroaLab @scienceadvocacy @MAFD110 @pietras_eric Looking forward! 😊

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@MullallyLab

Mullally Lab

11 months

Recent @MullallyLab retreat @Harvard Yard! Great day brainstorming on science, learning about our backgrounds, our career goals & developing new ideas for the future! @BrighamHeme @BrighamResearch @harvardmed @broadinstitute #MPNsm

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@MullallyLab

Mullally Lab

2 years

Excited to share these #ASH2022 abstracts from @MullallyLab - one will be presented by @AnnaMarneth , the other by Dr. Frederike Kramer: Excited to attend @ASH_hematology in-person this year! #MPNsm

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@MullallyLab

Mullally Lab

5 years

We discussed this superb paper from @AbdelWahablab in our lab journal club today. What a tour de force, so much data, congrats to all! 👍🏾

@AbdelWahablab

Abdel-Wahab Lab

5 years

Excited to share our new story in @nature on coordinated effects of alterations in RNA splicing and the epigenome in AML patients!

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@MullallyLab

Mullally Lab

3 years

Since I'm attending #ASH21 virtually this year & normally meet postdoc candidates in-person at the meeting, please email me if you're interested in joining @MullallyLab - we are recruiting! #MPNsm

@MullallyLab

Mullally Lab

3 years

@MullallyLab is recruiting postdocs to join our growing team ! Please send your CV & names of three referees to mullallylabbwh @gmail .com to apply. Please RT this! @BrighamHeme @BrighamResearch @DanaFarber @harvardmed @broadinstitute #mpnsm

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@MullallyLab

Mullally Lab

5 years

Mutant CALR is a phenomenal therapeutic target in MPN! Check out our Blood Spotlight, now out @BloodJournal in First Edition. Co-authored with @GabyHobbs & Dr. Joan How (awesome Heme/Onc Fellow). @BrighamHeme @DanaFarber @MGHCancerCenter #MPNsm Link here:

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@MullallyLab

Mullally Lab

4 years

What is the impact of JAK2V617F on native human hematopoiesis? Check out our abstract starting at 1.45pm PT today! #ASH20 #MPNsm @DanaFarber @BrighamHeme @MGHCancerCenter @BCHStemCell @embl @isidrolauscher @GabyHobbs @Baransel_Kamaz @LuskinMarlise

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@MullallyLab

Mullally Lab

1 year

Had a great visit to @WeillCornell yesterday! Huge thanks to Dr. Silver for inviting me to speak at MGR. Really enjoyed conversations with @DrJoeScandura @GhaithAbuZeinah @AnnaEnim & of course the fantastic @WeillCornell fellows! Super fun day discussing all things MPN! #MPNsm

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@MullallyLab

Mullally Lab

2 years

Our review "Biology & therapeutic targeting of molecular mechanisms in MPN" is out @BloodJournal , big thanks to my co-authors @joanhowMD & Dr. Jacqueline Garcia - hope all in MPN community find this useful, comments welcome! @BrighamHeme @DanaFarber #mpnsm

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Biology and therapeutic targeting of molecular mechanisms in MPNs

Our knowledge about the biology of myeloproliferative neoplasms (MPNs) has exploded in the last 20 years, and this increased knowledge has led to advances

ashpublications.org

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@MullallyLab

Mullally Lab

3 years

Final open access version of our article is now available @BloodAdvances ! @BrighamHeme @DanaFarber @ColemanLindsley @MPN_RF @LLSusa #MPNsm Genomic profiling of a randomized trial of interferon-α vs hydroxyurea in MPN reveals mutation-specific responses

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Genomic profiling of a randomized trial of interferon-α vs hydroxyurea in MPN reveals mutation-sp...

Key Points. Treatment with IFNα was associated with distinct molecular responses in patients with JAK2-mutated MPN compared with CALR-mutated MPN.Among pat

ashpublications.org

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@MullallyLab

Mullally Lab

10 months

This is soooo well deserved! Congrats Omar!! Science of the highest caliber since you started, bravo! @AbdelWahablab @MSKCancerCenter @ASH_hematology #ASH23

@DrAnasYounes

Anas Younes, M.D.

10 months

Congrats to ⁦Omar @AbdelWahablab ⁩ @msk for the #ASH23 Dameshek Award. Very well deserved !

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@MullallyLab

Mullally Lab

4 years

A fun aspect of our paper @CellStemCell was referencing 1991 paper from Dr. Gary Gilliland @fredhutch , then a postdoc @BrighamHeme , who used PCR (!) to show MPN are clonal & linking to seminal paper from @rosslevinemd , co-discoverer of #JAK2V617F in 2005 w/ Gary @BrighamResearch !

@CellStemCell

Cell Stem Cell

4 years

New Short Article online now CellStemCell: Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms

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@MullallyLab

Mullally Lab

11 months

Thank you @rosslevinemd for inviting me to speak @MSKCancerCenter y'day & for being so generous with your ideas & career advice, I always learn so much from you! Thanks also @KharasLab @AbdelWahablab @oleg8r @RaajitRampal @PedsHemeDoc @jzbos , so fun to talk science with you all!

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@MullallyLab

Mullally Lab

3 years

So proud of Drs. Anna Marneth & Jonas Jutzi, who led this work, collaborators @anandi_krishnan @JohnDoench & others! Also funding from @nih_nhlbi @CureCancerNow @LLSusa @BrighamHeme @DanaFarber @broadinstitute #ASH21 #MPNsm

@MPN_Hub

MPN_Hub

3 years

Congress| #ASH21 | Anna Marneth @harvardmed , describes data on a whole-genome CRISPR screen that identified N-glycosylation as an essential pathway for mutant CALR-driven oncogenesis; highlighting it as a potential novel therapeutic target for patients with CALR-mutant MPN. #MPNsm

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@MullallyLab

Mullally Lab

6 years

Farewell Dr. Shannon Elf! Off to start her own lab @UChicago . V. proud! Wish her every success. @MullallyLab is recruiting! #MPNSM #SHEmatology

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@MullallyLab

Mullally Lab

4 years

This video is awesome, congrats to Ben & everyone from the Ebert Lab who contributed to this great work!

@ScienceAcad_swe

The Royal Swedish Academy of Sciences

@ScienceAcad_swe

4 years

Benjamin Ebert receives this year’s Sjöberg Prize, worth one million US dollars, for his research into how lenalidomide works as a treatment for blood cancer. @DanaFarber @harvardmed @HHMINEWS @broadinstitute

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@MullallyLab

Mullally Lab

2 years

Congrats to Kate, Julie & everyone in @JulieLosman Lab, as well as collaborators, on this interesting study identifying KDM5 as a 2-HG target in IDH-mutant cancers - have seen this story develop in our shared lab meeting @DanaFarber - beautiful work, great to see it out @CD_AACR !

@ElizSMcKenna

Elizabeth McKenna

2 years

Now online in @CD_AACR : (R)-2-hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-mutant Cancers - by Kathryn Gunn, @JulieLosman , and colleagues @DanaFarber

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@MullallyLab

Mullally Lab

5 years

Beautiful Fall day y’day for ⁦ @MullallyLab ⁩ annual retreat ⁦⁦ @Harvard ⁩ yard. 🍁 Lots of brainstorming on science, career & collaborations ⁦ @BrighamHeme ⁩ ⁦ @df_hcc ⁩ ⁦ @broadinstitute ⁩ ! 🔬 Followed by bowling 🎳 & haute cuisine! 🍕🍔 Great day! 👍🏾

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@MullallyLab

Mullally Lab

4 months

Very proud to lead @StanfordHeme , read more about our great Division here!

@StanfordDeptMed

Stanford Department of Medicine

@StanfordDeptMed

4 months

Fresh faces & exciting developments in Hematology's Spring Newsletter! Meet @StanfordHeme 's new Division Chief Ann Mullally ( @MullallyLab ) & learn about the latest faculty awards & clinical trials:

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@MullallyLab

Mullally Lab

5 years

Very excited to speak @ Gender Equity in Science Forum ⁦⁦ @NDLR_conference ⁩ in 2020! #WomenInSTEM #girlsinSTEM

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@MullallyLab

Mullally Lab

5 years

⁦Comments in ⁦⁦ @CancerDiscover ⁩ ⁦from ⁦ @doctorpemm ⁩ & I on FDA approval for fedratinib in MF. ⁦ @StevenLane_QIMR ⁩ & I published pre-clinical studies of this drug (TG101348) in ⁦ @Cancer_Cell ⁩ in 2010. Its been a long road! 💊

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@MullallyLab

Mullally Lab

2 years

Postdoc candidates attending #ASH2022 , please email me if you're interested in joining us @MullallyLab - most recent lab photo below, we're expanding lab & I would love to hear from you & meet with you! @ASH_hematology @BrighamHeme @DanaFarber @harvardmed @broadinstitute #MPNsm

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@MullallyLab

Mullally Lab

2 years

Congrats to Dr. @jonas_jutzi , postdoc @MullallyLab on leading this study entitled, "CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response" now published in @LeukemiaJnl ! Read paper here:

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@MullallyLab

Mullally Lab

5 months

Shout out to @DrRolles @Cilomarf @MaxStahlMD with whom I'm studying TP53 mutations in MPN, a work in progress with much still to understand, great insights/feedback from MPN community @ESHaematology meeting #ESHMPN2024 , much appreciated! @BrighamHeme @BrighamResearch @DanaFarber

@ESHaematology

ESH (Haematology)

5 months

Thank you to Dr. Ann Mullally ( @MullallyLab ) for the fascinating talk on P53 in MPN. Dr. Mullally’s lab has worked to establish an incredible collection of P53 mutant MPN pt samples, using them to show P53 multi-hit mutations are associated with reduced survival. #ESHMPN2024

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@MullallyLab

Mullally Lab

2 years

Congrats to Dr. Frederike Kramer, postdoc @MullallyLab on presenting this poster @ #ASH22 characterizing Calr/Asxl1 co-mutant MPN, focusing on altered chromatin (histone H3) & aberrant megakaryopoiesis @AnnaMarneth @BrighamHeme @DanaFarber @broadinstitute @ASH_hematology #MPNsm

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@MullallyLab

Mullally Lab

3 years

Over 500 attendees @EHA_Hematology Mol Heme Workshop this morn' for a really fantastic & inspiring session! So thankful to all the presenters, to @EHA_Hematology staff, to my fab co-chairs Dr. Kim De Keersmaecker, @MilsomMick & especially to Dr. Thomas Mercher for leading us all!

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@MullallyLab

Mullally Lab

2 years

Congrats to @AnnaMarneth , co-authors @jonas_jutzi , & other @MullallyLab members; also @joanhowMD @LuskinMarlise @ColemanLindsley @MaxStahlMD & especially Dr. Edie Crosse @bradleybio lab for completing RNA-seq analysis before #ASH22 @ASH_hematology @BrighamHeme @DanaFarber #MPNsm

@MPN_Hub

MPN_Hub

2 years

#ASH22 | @AnnaMarneth @harvardmed gives a talk on how SRSF2mut lowers JAK2 erythrocytosis in mice and is linked with lower Hb in pts with chronic JAK2mut #MPN . She highlights that the data may help identify novel therapeutic targets to reduce anaemia #MPNsm #medicalcongress

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@MullallyLab

Mullally Lab

1 year

Congrats @RossLevineLab & colleagues on this great paper on CXCL8/CXCR2 in myelofibrosis: @StevenLane_QIMR , could it be that you're invoking Dylan in the @BloodJournal commentary? Shelter from the cytokine storm in myelofibrosis

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Shelter from the cytokine storm in myelofibrosis

Cytokines are key proinflammatory messenger molecules that help to regulate the immune system and inflammatory responses. They are well established in the

ashpublications.org

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@MullallyLab

Mullally Lab

10 months

@MullallyLab heading home after a fantastic #ASH23 ! So proud of our team & great to see our fab alum @AnnaMarneth ! An exciting time to be working in MPN with great science & new drugs! Thank you @MPN_RF @nih_nhlbi @LLSusa & others for your support! @BrighamHeme @DanaFarber #MPNsm

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@MullallyLab

Mullally Lab

1 year

Thrilled to share our review out now in @BloodJournal : Biology and therapeutic targeting of molecular mechanisms in MPNs

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Biology and therapeutic targeting of molecular mechanisms in MPNs

Our knowledge about the biology of myeloproliferative neoplasms (MPNs) has exploded in the last 20 years, and this increased knowledge has led to advances

ashpublications.org

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@MullallyLab

Mullally Lab

6 years

Energized after #ASH18 , @MullallyLab is recruiting postdocs to join our team!

@BrighamHeme

Brigham and Women’s Hematology

6 years

Dr. Ann Mullally from @BrighamHeme @MullallyLab provides introduction, background, and context for the #ASH18 plenary talk on calreticulin mutations in MPNs. @ASH_hematology @BrighamWomens

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@MullallyLab

Mullally Lab

5 years

Wonderful profile of former @MullallyLab postdoctoral fellow, Dr. Shannon Elf, now blazing her own trail @UChicago ! Congrats to Shannon on @LLSResearch CDP Achievement Award. So proud of Shannon’s accomplishments & honored to be in the esteemed group of her mentors.

@LLSResearch

Leukemia & Lymphoma Society Research

5 years

: CDP Achievement Award winner Shannon Elf is featured in our latest Spotlight! Having started her career dissecting mutant CALR in MPNs @BrighamWomens , Dr. Elf now leads a @UCCancerCenter lab @UChicago identifying other pathways critical for #MPN and #AML .

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@MullallyLab

Mullally Lab

5 months

Really enjoying transition to Cali living! Afro-Cuban jazz by @AlexCuba @BingTheater @Stanford Fri night (fab!) sponsored by @StanfordMed , hiking Foothills Nature Preserve @cityofpaloalto y'day! Did I mention @MullallyLab is recruiting? Come join us! @StanfordDeptMed @VAPaloAlto

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@MullallyLab

Mullally Lab

6 years

Inspired by @DavidSteensma , @MullallyLab is now on Twitter! #ASH18

@DavidSteensma

David Steensma, MD

6 years

Backstage, Green Room, #ASH18 Plenary Session, just a few minutes before “curtain”. Everyone acting composed... but trembling hands and rapid JVP waves speak of the fact that I am not the only one w/ sinus tach! Hanging out with Dr Ann Mullally @BrighamWomens in queue for makeup

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@MullallyLab

Mullally Lab

3 years

Fantastic to see women on the walls @harvardmed Women Before Me

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The Women Before Me

An online exhibit of portraits honors HMS alumnae

hms.harvard.edu

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@MullallyLab

Mullally Lab

4 years

Review from Dr. Jonas Jutzi ( @MullallyLab ) and I out now! #MPNsm Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN

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@MullallyLab

Mullally Lab

3 years

Very excited to chair a session in fantastic EHA Molecular Hematopoiesis Workshop, which takes place TOMORROW, June 9, from 9:00 to 12:00 CEST! (i.e. 3:00 to 6:00 EDT, ready for an early start!)

@EHA_Hematology

European Hematology Association

@EHA_Hematology

3 years

2 days left till🚀 #EHA2021 Virtual! Stay tuned for 9 exciting Congress days offering you the latest news and developments in #hematology and its sub specialties. (All sessions will be available on-demand on the Congress platform until August 15!) Register:

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@MullallyLab

Mullally Lab

11 months

Great to re-connect with the amazing @rschneiderlab , Scientific Committee Member for the Annual @oncodeinstitute Meeting, congrats to Rebekka & everyone involved this wonderful meeting!

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@MullallyLab

Mullally Lab

3 years

In 2018, I had honor of introducing @ASH_hematology plenary on CALR-mutant MPN, elegant work from @Stefan_constan & others! Tune in tomorrow @ 10.15 for #ASH21 abstract from @MullallyLab & others on whole-genome CRISPR screening in CALR-mutant MPN #MPNsm

@BrighamHeme

Brigham and Women’s Hematology

6 years

Dr. Ann Mullally from @BrighamHeme @MullallyLab provides introduction, background, and context for the #ASH18 plenary talk on calreticulin mutations in MPNs. @ASH_hematology @BrighamWomens

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Mullally Lab

3 years

Tis' the ASH season Mullally Lab presents CALRETICULIN! #ASH21 #ASHHaiku

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Mullally Lab

4 years

Thinking of all my patients today, #MPNAwarenessDay ! @MullallyLab is committed to advancing the understanding of MPN biology & in particular to developing new therapies with disease-modifying activity. Grateful to @MPN_RF , @CureCancerNow @LLSusa , @nih_nhlbi for funding! #mpnsm

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Mullally Lab

2 years

Congrats to Dr. @melo_cardenas1 & #CrispinoLab on their exciting study out now @BloodJournal Dr. @jonas_jutzi & I enjoyed writing the commentary, including movie reference! #mpnsm Two to tango! IL-13 and TGF-β drive myelofibrosis

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Two to tango! IL-13 and TGF-β drive myelofibrosis

In this issue of Blood, Melo-Cardenas et al explore the role of interleukin-13 (IL-13)/IL-4 signaling in myelofibrosis as an important pathway driving fibr

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@MullallyLab

Mullally Lab

5 years

Tonight at #ASH2019 , I will be discussing JAK-STAT signaling, ruxolitinib, fedratinib & an interesting case of PV from my clinic! Should be a great session on PV & MF! #mpnsm

@MullallyLab

Mullally Lab

5 years

My Friday night plans at #ASH2019 ! MPN Tumor Board: Application of Novel Agents for the Treatment of PV & MF. Fri. Dec 06, 6pm - 10pm Hyatt Regency Orlando, Plaza International I-K Chair: Ronald Hoffman, MD Speakers: Rami S. Komrokji, MD Ann Mullally, MD Abdulraheem Yacoub, MD

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@MullallyLab

Mullally Lab

2 years

Beautiful work from @TothovaLab uncovering therapeutic vulnerabilities in cohesin-mutant myeloid malignancies, presented by Dr. Zuzana Tothova in the fantastic myeloid workshop at #ASH22 in NOLA! @ASH_hematology @DanaFarber @broadinstitute

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@MullallyLab

Mullally Lab

4 years

Just recorded my talk for this meeting! Fantastic line up including @harrisoncn1 @Vikas_Gupta_1 @AaronGerds @PedsHemeDoc @jjkiladjian @KuykendallMd @mpdrc @lauracmichaelis @doctorpemm @RaajitRampal @AYACOUB7 @MPNlab amongst many others! Looking forward ! 😊 #MPNsm

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Mullally Lab

6 months

Great to be here for #ESHMPN2024 , fantastic meeting now underway! #MPNsm

@ESHaematology

ESH (Haematology)

6 months

🤝 Welcome to #ESHMPN2024 ! Stay tuned! ESH Young Scientific Reporters @r_gelfer & @Wang_Yu_Hung will provide regular updates on the conference! 10th Translational Research Conference on #MPN Chairs: @jjkiladjian , @rosslevinemd , @jyoti_nangalia #ESHCONFERENCES #HAEMATOLOGY #MPNsm

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@MullallyLab

Mullally Lab

2 years

Super excited & honored to speak in this #ASH22 session starting @ 9.30am today! I will talk about "MPN as a paradigm for clonal dominance & myeloid transformation" - thanks so much to @purton_louise & @FD_Camargo for organizing! @ASH_hematology @BrighamHeme @DanaFarber #MPNsm

@purton_louise

Prof Louise Purton

2 years

#ASH22 great sessions today! I am looking fwd to more tomorrow, excited to co-chair (with @FD_Camargo ) the scientific session on Cell Competition & Clonal Hematopoiesis! Speakers Dr Laura Johnston, @AlejoFraticelli @MullallyLab & Dominique Bonnet. New Orleans Theater AB 9.30am.

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Mullally Lab

5 years

So proud to have trained @OslerResidency #WeAreBaltimore

@OslerResidency

The Osler Medical Residency

@OslerResidency

5 years

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@MullallyLab

Mullally Lab

5 years

As physician-scientists we are an endangered species! Many potential reasons for this but early career funding specifically for this group is key I think. Grateful to @DamonRunyon and @LLSResearch for recognizing this & supporting us!

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@MullallyLab

Mullally Lab

4 years

Huge thanks to @RWinneker @MPN_RF @RaajitRampal @mpndoc for organizing inaugural MPN Progression Research Network Mtg & to everyone including @rschneiderlab @jjkiladjian @mpdrc @rosslevinemd @bloodgenes @Jyoti_Nangalia @KuykendallMd for fab input! Proud to participate! #MPNsm

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Mullally Lab

8 months

Thanks so much for the invitation @NYULH_DeptofMed , I really enjoyed engaging with everyone @nyugrossman !

@NYULH_DeptofMed

NYU Department of Medicine

@NYULH_DeptofMed

8 months

It was an honor to have Dr. Ann Mullally @nyugrossman today, giving an outstanding Med #GrandRounds to advance our understanding of JAK-2 mutant clonal hematopoiesis & MPN @MullallyLab @BrighamHeme @BrighamResearch @DanaFarber @broadinstitute

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@MullallyLab

Mullally Lab

10 months

Sharing our poster, now being presented by Dr. Swarna Bale, project led by ⁦ @AnnaMarneth ⁩ #ASH23 ⁦ @BrighamHeme ⁩ ⁦ @DanaFarber ⁩ ⁦ @ASH_hematology ⁩ #MPNsm

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@MullallyLab

Mullally Lab

2 years

Congrats to @jonas_jutzi & Anna Marneth @MullallyLab for leading this work @BloodJournal , thanks to our collaborators @BrighamHeme @DanaFarber @broadinstitute @UChicago @StanfordMed @CNIOStopCancer & our funders @nih_nhlbi @LLSusa @CureCancerNow #MPNsm

@jonas_jutzi

Jonas Jutzi

2 years

Very happy and grateful to share our latest publication in Blood, hot off the virtual press:

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@MullallyLab

Mullally Lab

5 years

Thankful to @MPN_RF for funding this important initiative on MPN Progression @DanaFarber @BrighamHeme . Fortunate to have genomics expertise from @ColemanLindsley & fantastic colleagues in MDS @DavidSteensma & myeloma @IreneGhobrial who have paved the way for this work! #MPNsm

@MPN_RF

MPN Research Foundation

5 years

Committed to investing in research that could lead to a better understanding & prevention of progression from PV/ET to MF, #MPNRF has made its first strategic investment in this area with a 1yr grant to Dr. Ann Mullally ( @MullallyLab ) at @DanaFarber #MPNSM

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Mullally Lab

4 years

Editorial from Dr. Anna Marneth ⁦(⁦ @MullallyLab ⁩ ) and I in ⁦ @Haematologica ⁩ on new paper exploring role of PDGF signaling in myelofibrosis #MPNsm

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@MullallyLab

Mullally Lab

2 years

Congrats to Dr. Jonas Jutzi @MullallyLab @BrighamHeme on a fantastic oral abstract presentation @EHA_Hematology #EHA2022 today! Thanks to our fab collaborators @AnnaEnim @falshahrour @vangalenlab & proteomics @broadinstitute , also funders @LLSusa @nih_nhlbi @CureCancerNow #MPNsm

@MPN_Hub

MPN_Hub

2 years

Congress| #EHA2022 Jonas Jutzi, @BrighamHeme discusses the mechanisms by which CALR mut cells alleviate ER stress and how to exploit this. He highlights that disrupted proteasis results in dependency on the IRE1-XPB1 axis of the UPR and proteasome activity #MPN #medicalcongress

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@MullallyLab

Mullally Lab

10 months

Congrats to Dr. Benjamin Rolles @DrRolles for summarizing his #ASH23 abstract w/ @Cilomarf on TP53 mutations in MPN so well in this video @Blood_Cancers ! We continue to work on this project with @MaxStahlMD & many others @DanaFarber . @BrighamHeme @ASH_hematology #MPNsm

@Blood_Cancers

Blood Cancers Today

10 months

Benjamin Rolles ( @DrRolles ), of @BrighamResearch at @HarvardMed , stopped to chat with Blood Cancers Today at #ASH23 ! Dr. Rolles discussed his abstract on TP53 mutations in patients with MPNs who were treated at @DanaFarber . Check it out ➡️

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@MullallyLab

Mullally Lab

4 years

Just wanted to introduce Dr. Joan How to @ESHaematology community. Joan is finishing heme/onc fellowship @df_hcc and will start as faculty @BrighamHeme this summer. She has a long track record of #mpn research with @mpndoc , @GabyHobbs & I. Please welcome Joan to our MPN group!

@joanhowMD

Joan How

4 years

Another great day of discussions! Particularly enjoyed participating in the Meet the Expert session with @MullallyLab and @jyoti_nangalia about clonal evolution in MPNs. Thank you @ESHaematology for putting together a great conference! #ESHCMLMPN2021

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@MullallyLab

Mullally Lab

4 months

Congrats to all the recipients of @ASH_hematology 2024 Honorific Awards! A big @StanfordHeme shout out to Dr. Ami Bhatt, recipient of the Dameshek Award. Our Division is so proud of Ami on this well deserved award & the honor it brings to her, to all of us & to @StanfordDeptMed !

@ASH_hematology

ASH

@ASH_hematology

4 months

A huge #ASHKudos to the 2024 ASH Honorific Award recipients! This year’s recipients are a group of pioneering scientists, innovative clinicians, and selfless mentors who have advanced hematology through vital contributions! #ASHAwards #ASH24 #hematology

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@MullallyLab

Mullally Lab

3 years

I am chairing part three of EHA Mol Heme Workshop on transcriptional & epigenetic regulation starting at 11am CEST tomorrow June 9 - speakers are Daniel Coleman, @JulesMeijerink , Cryril Broccardo, Marlies Rossmann & @lindemilesphd - promises to be a great session!

@EHA_Hematology

European Hematology Association

@EHA_Hematology

3 years

2 days left till🚀 #EHA2021 Virtual! Stay tuned for 9 exciting Congress days offering you the latest news and developments in #hematology and its sub specialties. (All sessions will be available on-demand on the Congress platform until August 15!) Register:

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@MullallyLab

Mullally Lab

4 years

Congrats - fantastic presentation! @jyoti_nangalia @ASH_hematology #ASH20 #MPNsm

@doctorpemm

Naveen Pemmaraju, MD

4 years

#ASH20 #LBA1 . Superb presentation and #ASHKudos to Dr . @jyoti_nangalia & team !!! Congratulations on the is amazing ground-breaking work in our #MPNSM field !! Driver mutation Acquisition in utero & childhood followed by lifelong Clonal evolution underlie MPNs @ASH_hematology

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Mullally Lab

4 years

Proud to contribute a recorded lecture on MPN for this Hematology Review Series organized by @ASH_hematology for fellows & trainees! #mpnsm Hematology Review Series -

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Mullally Lab

4 months

Proud to be a member of this fab group @StanfordDeptMed - super collegial & fun!

@JoyYWu

Joy Wu, MD, PhD

4 months

Bittersweet farewells to departing chiefs Upi Singh @Stanford_Med_ID + @WRayKimMD @Stanford_GI (thanks for hosting!) and warm welcomes for @LindaNguyenMD @Stanford_GI + @MullallyLab @StanfordHeme . Grateful for the camaraderie of this group of @StanfordDeptMed division chiefs!

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@MullallyLab

Mullally Lab

1 year

Fascinating biology also relevant to MPN where germline variants in TERT are associated with MPN risk, as reported by @bloodgenes & others and patients with MPN have shorter telomeres. Great Tweetorial @pnatarajanmd ! #MPNsm

@pnatarajanmd

Pradeep Natarajan

1 year

Super cool observation that a monogenic mechanism of longer telomeres yields familial clonal hematopoiesis of indeterminate potential. @NEJM This is super cool bc it's not the expectation as @ginakolata @nytimes explains () 🧵👇

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@MullallyLab

Mullally Lab

2 years

Thank you @BloodJournal @ASH_hematology for highlighting our paper! @jonas_jutzi @AnnaMarneth @BrighamHeme @BrighamResearch @DanaFarber @broadinstitute @ElfLabUChicago @anandi_krishnan @StanfordMed @falshahrour @CNIOStopCancer @nih_nhlbi @LLSResearch @CureCancerNow #MPNsm

@BloodJournal

Blood Journal

2 years

Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs

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@MullallyLab

Mullally Lab

11 months

I should also add that funding from @MPN_RF was important in helping advance MPN-related studies as part of the Heme Malignancies Data Repository (HMDR) @DanaFarber & in supporting the work of @joanhowMD @BrighamHeme & @SahandHormoz @dfcidatascience & of course @MullallyLab too!

@MullallyLab

Mullally Lab

11 months

As #ASH2023 approaches, I wanted to share some @ASH_hematology abstracts from our MPN cohort @DanaFarber @BrighamHeme now comprising approx 1300 patients on whom we have comprehensive molecular genetic profiling, clinical data, labs and pathology. Three abstracts to follow #MPNsm

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Mullally Lab

5 years

My Friday night plans at #ASH2019 ! MPN Tumor Board: Application of Novel Agents for the Treatment of PV & MF. Fri. Dec 06, 6pm - 10pm Hyatt Regency Orlando, Plaza International I-K Chair: Ronald Hoffman, MD Speakers: Rami S. Komrokji, MD Ann Mullally, MD Abdulraheem Yacoub, MD

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Mullally Lab

10 months

Highly recommend this Tweetorial and preprint dissecting the biology of blast phase MPN. @CKBrierley gave an outstanding presentation of this elegant and important work at #ASH23 , definitely one of my highlights of the meeting! Congrats to all involved! @ASH_hematology #MPNsm

@CKBrierley

Charlotte Brierley

10 months

Heading home from #ASH23 ? 👩‍💼🌞🌮Stuck in a line at security or facing a long layover? ✈️In withdrawal from all the amazing science? 🧪🧬 Read our preprint from my PhD work @UniofOxford @MRC_WIMM presented in the MPN session yesterday! 1/n

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@MullallyLab

Mullally Lab

4 years

MPN meets Montaigne! Nice commentary from Drs. Norfo & Mead - with new MPN insights come more questions! @AdamMead_Oxford @ASH_hematology #MPNsm Clonal Selection of Mutant HSC in MPN: “What Do I Know?” | The Hematologist | American Society of Hematology

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Mullally Lab

4 years

Nice commentary on recent paper from Dagher et al. @Institut_IRSL using MPN mouse models to show Jak2-mutant HSC are preferentially sensitive to IFN/ATO combination - direct translational relevance! @StevenLane_QIMR @jjkiladjian @MPN_RF #mpnsm

@JExpMed

JExpMed

4 years

Bywater & Lane @QIMRBerghofer provide insights into work by Dagher et al () who combine arsenic & interferon α to deliver a knockout punch to myeloproliferative neoplasm (MPN) stem cells & provide new hope to cure patients with MPNs

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Mullally Lab

3 years

Congrats to @HmzaCelik @challenlab @mpndoc & all authors of this detailed study @CD_AACR showing that MPN PDX models are feasible. Interesting that sub-clinical "aggressive" sub-clones were positively selected for in vivo. CD34+ cells injected via intra-tibial injection! #MPNsm

@challenlab

Grant Challen

3 years

The @HmzaCelik legacy paper. We hope all MPN researchers can adopt this model to study primary patient cells in vivo. Let us know if we can help. Big thanks to @CD_AACR , collaborators like @mpndoc , funding bodies @LLSusa @nih_nhlbi and of course our patients!

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@MullallyLab

Mullally Lab

5 months

Phenomenal meeting, huge thanks to @jyoti_nangalia @jjkiladjian @rosslevinemd for putting together such a superb program, I'm proud to have participated. Big thanks to @ESHaematology for superb organization. #MPNsm

@ESHaematology

ESH (Haematology)

5 months

🎉 #ESHMPN2024 Many thanks to @jjkiladjian , @rosslevinemd , @jyoti_nangalia & all the faculty members for this remarkable meeting in Mandelieu 🇫🇷 We also thank all the participants for their questions & comments! Don't miss upcoming #ESHCONFERENCES : visit

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@MullallyLab

Mullally Lab

5 years

Check out our poster at #ASH19 on genomics & interferon in MPN. Mon 6-8pm. Interesting findings on CALR & DNMT3A mutations. Great collaboration with Danish MPN investigators & ⁦ @ColemanLindsley ⁩, funded by ⁦ @MPN_RF ⁩ ⁦ @LLSResearch ⁩ #MPNSm

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@MullallyLab

Mullally Lab

5 years

@KharasLab describes innovative ways to study RNA binding proteins in HSC, kicking off a fantastic molecular hematopoiesis workshop this morning @EHA_Hematology in the wonderful city of Amsterdam! 🚲🇳🇱 #EHA24

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@MullallyLab

Mullally Lab

4 years

Big shout-out to all my phenomenal female colleagues & collaborators in hematology on #InternationalWomensDay ! @GabyHobbs @joanhowMD @connors_md @LuskinMarlise @TothovaLab @DebraVanEgeren @julieclng @rschneiderlab @ASH_hematology

@ASH_hematology

ASH

@ASH_hematology

4 years

Happy #InternationalWomensDay to all of our #shematologists who work with us! 🎉 Today we give a special thanks to our Women In Hematology Working Group who are dedicated to supporting the careers of women hematologists.

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@MullallyLab

Mullally Lab

1 year

Check out this review, co-authored with Dr. Frederike Kramer @MullallyLab @BrighamHeme @BrighamResearch #MPNsm Antibody targeting of mutant calreticulin in myeloproliferative neoplasms - Journal of Cellular and Molecular Medicine - Wiley Online Library

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Antibody targeting of mutant calreticulin in myeloproliferative neoplasms

Overview of pathogenic mechanisms of mutant calreticulin (CALR) in myeloproliferative neoplasms (MPN) and potential ways to target the mutant calreticulin neoantigen by therapeutic monoclonal...

onlinelibrary.wiley.com

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@MullallyLab

Mullally Lab

7 months

Honored to join the exceptional group of Division Chiefs @StanfordDeptMed @StanfordMed including @HwakeleeMD , @JoyYWu , @EldrinL , @taraichang , @Neera_Ahuja & many more not on X. Looking forward to working with @SCIDirector , Dr. Steven Artandi. /3

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Mullally Lab

3 years

Come join us @BrighamHeme @BrighamResearch Great environment, phenomenal colleagues, exceptional trainees and Boston winters really aren't that bad, haha!

@BrighamHeme

Brigham and Women’s Hematology

3 years

The Hematology Division @BrighamWomens @harvardmed is recruiting for clinical faculty as well as basic/translational science faculty positions. See attached description for details.

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@MullallyLab

Mullally Lab

3 years

@MullallyLab is recruiting POSTDOCS & RESEARCH TECHNICIANS to join our growing team ! Please send your CV & names of three referees to mullallylabbwh @gmail .com to apply. Please RT this! @BrighamHeme @BrighamResearch @DanaFarber @harvardmed @broadinstitute

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@MullallyLab

Mullally Lab

3 years

Congrats, Anna! @MullallyLab @BrighamHeme

@doctorpemm

Naveen Pemmaraju, MD

3 years

#ASH21 #MPNSM oral session. Dr Anna E Marneth Whole-genome #CRISPR screening : N-glycosylation as an essential pathway and a potential novel therapeutic target in #CALR -mutant MPN @mpndoc @AaronGerds @rschneiderlab @ASH_hematology

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@MullallyLab

Mullally Lab

11 months

Just finished putting together my slides for @MedscapeLIVE symposium on myelofibrosis #ASH23 Looking forward to this, to prep I re-read recent great work from @mpndoc @Vikas_Gupta_1 @AlbaRMeira @AdamMead_Oxford @RossLevineLab @RaajitRampal @jyoti_nangalia amongst others! #MPNsm

@MedscapeLIVE

MedscapeLIVE

1 year

❓ Did you know that epigenetic therapies can potentially change the path of a patient’s journey with myelofibrosis? Join experts @MullallyLab , John Mascarenhas, MD, MS, Claire N. Harrison, DM, FRCP, FRCPath & Ronald Hoffman, MD December 8 at #ASH2023 👉

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