The Yonker Lab at Mass. General Hospital studies neutrophilic airway inflammation, as seen in pediatric COVID-19, cystic fibrosis, and childhood pneumonia.
Does your child suffer from
#LongCovid
?
We are studying to see if larazotide improves symptoms in children 7-21 years old.
The study involves 2-3 in-person visits to MGH in Boston, plus 4 virtual visits over 8 weeks.
Contact ssossi
@mgh
.Harvard.edu
#LongCovidKids
Does your child suffer from
#LongCovid
?
We are studying to see if larazotide improves symptoms in children 7-21 years old.
The study involves 2-3 in-person visits to MGH in Boston, plus 4 virtual visits over 8 weeks.
Contact ssossi
@mgh
.Harvard.edu
#LongCovidKids
Thrilled to be a member of this Consortium and co-author on this paper. We are working very hard to move research on SARS-CoV-2 persistence and
#LongCovid
in children.
Tell
@ChrisCuomo
that 33 scientists from 14 institutions joined forces to write this paper documenting evidence for
#SARS
-CoV-2 persistence as a potential driver of
#LongCOVID
. We call for more clinical trials of drugs capable of clearing persistent virus:
So incredibly honored to be awarded the Robert B Mellins Outstanding Achievement Award
@ATSPeds
🙏☺️🙏☺️🙏
Pic with proud division chief, Bernard Kinane, and Ben Nelson, highly deserving recipient of Clinical Educator Award
@mghfc
@MghfcPulmFellow
#ATS2023
A must read summary of what we know and where things stand for Long COVID.
Importantly- this article acknowledges that kids, too, can suffer from viral persistence and
#LongCOVID
.
POV, poster sessions:
-10% telling people about your research
-10% catching up with friends and colleagues
-80% smiling at people as they walk by avoiding eye contact 😆
#PAS2024
Thank you for highlighting our work
@EricTopol
! mRNA vaccines work very well in kids! Definitely better immune response than from infection alone.
#VaccinesWork
Just out
@ScienceTM
The robust antibody immune response that an mRNA vaccine induces in children, including "highly preserved omicron-specific functional immunity"
@ragoninstitute
COVID vaccines clearly reduce risk of severe disease/complications. Rarely, post-vaccine myocarditis can occur.
Grateful for this collaborative effort to understand why this happens.
Hope this helps treatment/vaccine development.
@MGH_RI
@BrighamResearch
@BCH_Innovation
The
#larazotide
trial for pediatric
#LongCOVID
, as discussed in
@ScienceMagazine
.
Happy to talk to families and providers. Contact me at lyonker
@mgh
.harvard.edu if interested in learning more for your child/patients!
Congrats to
@ab_kane
on her latest publication highlighting a new biomarker for
#COVID19
severity in kids! 👏👏👏
Monocyte anisocytosis (MDW) corresponds with increasing severity of COVID-19 in children
Excited to be part of the
@mghfc
team working to advance treatments for children with
#MISC
after
#COVID19
. Larazotide has excellent safety profile and seems to resolve symptoms and antigenemia more quickly- now in placebo controlled trial. Stay tuned!
💊
@LaelYonker
and a team at
@MassGeneralNews
and
@BrighamWomens
identified a promising drug candidate for the treatment of multi-inflammatory syndrome in children (
#MISC
), a rare but potentially life-threatening condition that can develop after
#COVID19
.
The PolyBio Fall Symposium is this Friday! Join us for an afternoon of
#infection
-associated chronic disease project updates, insights, and discussion.
Check out the schedule & register here:
What about the
#LongCovidKids
that have to miss school? What will the long term economic cost be for the next generation??
We have to get these kids feeling better and back on track.
The economic cost of
#LongCovid
covid is staggering!
In the US,
#LongCovid
could result in 1.5 billion work hours lost in 2024 – a potential cost of more than US$152.6 billion
A report by
@TheEconomist
We found kids were most infectious in the first 5 days of
#COVID19
. The
#CDC
recommendation for a 5 day quarantine makes sense for children too.
@DrJLi
@AAPPres
via
@CDCgov
I worry about kids and COVID and MIS-C. Vaccinations (and boosters!) protect kids from severe Illness - urge your friends, neighbors, social media network to vaccinate their kids! (And wear masks) 🙏🙏🙏
Lael Yonker, MD,
@mghfc
, on the risks + potential
#COVID
complications for children, including acute COVID +
#MIS
-C--a rare but serious condition. As a pulmonologist + a parent, Dr. Yonker advises on how we can protect our kids.
@harvardmed
@LaelYonker
Amy Barczak, Jon Li
@DrJLi
, Julie Boucau, and team are incredible virologists/ID docs committed to advancing our understanding of COVID-19 in kids. Those kids’ high viral loads are from live, infectious virus! Mask up in schools/indoors, vaccinate!
@mghfc
@AAPNews
@MGH_RI
Another study showing that
#MISC
may originate in the gut- increased
#zonulin
and claudin are found in MISC. At
@mghfc
, we are studying the effect of zonulin inhibitor, larazotide, on the resolution of MISC.
Headed to
#PAS2024
!
My first time at PAS 🤩
Excited to meet/see pediatric friends and colleagues, share my poster on monocyte anisocytosis in pediatric sepsis, and learn from all you smart pediatricians out there!
#PASfootwear
Tagging
@mghfc
😊
Steps to Participate:
1. Share a shoe picture using
#PAS2024
and
#PASfootwear
2. Tag
@PASMeeting
3. Follow us (X)
As A Thank You for Participating:
1. One winner will be randomly selected and announced on Monday, May 13, 2024
2. Prize: $200 Amazon Gift Card
Maybe this is why kids have milder
#Covid_19
?
Kids have stronger nasal mucosal cytokine responses despite similar/milder systemic response.
Maybe vaccines should target nasal mucosal responses 🤔
Another lesson taught by kids!
Key points (
#2
)
- in MISC, Spike enters the blood (from the zonulin-mediated leak of GI reservoirs) —> spike:antibody complexes trigger
#NET
formation.
-IgA Spike immune complexes are most inflammatory.
-addressing GI Spike leak will be important for treatment for
#MISC
Looking for a research tech and a post doc to join our lab to study Pedi COVID/MIS-C!
Please contact me with leads/interest for either position. And please RT!
Pic from today’s lab outing 🎃
Please take a moment to read this beautifully written piece and get a glimpse of what it’s like to have
#LongCovid
@giorgialupi
Thank you for sharing your story!
@resiapretorius
@bpboribong
@MBVanElzakker
Yes! We’ve seen in other post-COVID syndromes in children (MIS-C) that Spike-immune complexes induce NETosis. We are looking to define neutrophil profiles in pediatric Long COVID as well.
Another great summary of COVID-19’s impact by
@LizSzabo
- this time on the effects of maternal COVID-19 on the baby (esp boys- so fascinating). The benefits of vaccinating pregnant moms are clear!
@EdlowLab
@evanbordt
Setting up a Pediatric COVID-19 biorepository was a ton of effort- hopefully this manuscript will make it easier for you! There is so much to learn about how kids are affected by
#COVID19
!
@MGH_RI
Celebrating >1 year of the Pediatric
#COVID19
Biorepository! 1000+ children enrolled, countless samples processed/charts reviewed, and numerous contributions to science. Proud of this team and all who’ve contributed!
@mghfc
@MGH_Mucosalists
Excellent and thought provoking hypothesis by
@BrodinPetter
of why kids can have mild COVID-19 then develop severe MIS-C weeks to months later. Tolerance to the initial infection may allow virus to stay in gut longer, leak thru gut wall, and trigger T cell activation.
How come
#COVID19
is mostly mild in children? and at the same time, why do the rare hyperinflammatory syndrome
#MISC
affect mostly young people, and not the elderly? thread🧵and a hypothesis:
So grateful to work with this incredible research group, it’s bittersweet when people move on! Congrats to
@MadeleineBurns_
CRC extraordinaire as she heads to med school!
@mghfc
@MGH_Mucosalists
An incredible honor to be amongst these women highlighting key advances in OSA (
@BrownOlufunke
), Pedi Pulm workforce issues (Jen Rama), pedi COVID (me 😁), and health care equity (Beverly Sheares). Thank you,
@KidsLungDoc
and
@terrilaguna
!
#ATS2022
Key points:
-even in mild Pedi COVID, neutrophils display IFN signaling
-Neutrophils in MISC show sepsis-like gene expression: high degranulation, TNF and IL-1 signaling
-Neutrophils in MISC *spontaneously* form
#NETS
intravascularly (can’t be good…)
(Read on…)
So thrilled to share the culmination of a lot of hard work, especially by research coordinator extraordinaire
@MadeleineBurns_
Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Infection via
@JAMA_current
@JAMANetwork
🧵
One of the things I love about
@MassGenBrigham
is the close collaboration between Pediatric and Adult clinics and research.
Pic of Adult CF Program Co-Director (Lenny Sicilian) and Pedi CF Program Director (me) at
#NACFC2023
😁🙏
@mghfc
@MGH_PCCM
In extreme cases, we see prolonged SARS-CoV-2 in the gut results in dysbiosis, zonulin release, increased permeability of the gut barrier, and Spike SuperAntigenemia—> results in MIS-C.
@ArditiMd
@MGH_Mucosalists
Extremely fortunate to work with postdoctoral fellow/future pediatrician,
@ab_kane
, who was featured in
#HumansofMGRI
She’s been instrumental in advancing our understanding of
#MISC
,
#COVID19
and pediatric respiratory mucosal immunity!
Loved seeing friends, colleagues, even some patients out on the
@CF_Foundation
Cycle for Life yesterday!
Such an incredible community- we’ve come a long way but still striving for the cure!
Plus a great break from grant writing 😁
@ab_kane
Thanks to
@CF_Foundation
for giving me the opportunity to make my plea! Children > 5yrs old with
#cysticfibrosis
should get vaccinated! (Along with their sibs and friends >5yrs old!)
Following the onset of the pandemic, Dr. Lael Yonker, a pediatric pulmonologist and director of the
@MassGeneralNews
CF Center, focused on studying how
#COVID19
affects children with CF. Today, she shares what she has learned from her research.
📌
#LongCovidKids
Study Announcement
Here is some information about the hypothesis behind the study led by
@LaelYonker
:
Zonulin is a protein that regulates intestinal permeability by controlling tight junctions in the intestines. When zonulin levels are higher than usual,
Do kids respond to mRNA vaccines like adults? How does the vaccine dose impact the quality/efficacy of the antibody response? We felt these were important questions too!
@mghfc
@MGH_RI
@ragoninstitute
We got tired of the usual line up for photos so we did something a little different for Jameson’s last day😁🤗.
Best wishes with your next adventure, Jameson!!
#ATS2023
🙌🙌🙌
Loved hearing the latest science, seeing colleagues and collaborators, and catching up with friends!
(And love the irony that conferences get the local MGH’ers together 😁)
@mghfc
@MghfcPulmFellow
Check out our amazing
Mucosal Immunity/Pediatric Research gingerbread house!!
Clearly this pediatric patient gummy worm has encountered a SARS-CoV-2 nerd cluster. 😁
#MGH
physicians
@DNBernsteinMD
and
@LaelYonker
MD were selected to participate in the
@theNAMedicine
Young Leaders Forum. This forum recognizes early- and mid-career professionals with exceptional professional promise, achievement and leadership in health and related fields.
In a May study in
@jclinicalinvest
,
@LaelYonker
showed that more than half of patients with MIS-C had genetic material — called RNA — from the coronavirus still in their stool, suggesting virus is living in their gut, even though it's gone from their nose.
I knew this day would come but how did it get here so fast?
@bpboribong
completed her post-doc and is moving up and moving on!
So incredibly grateful for her hard work, dedication, and teamwork. 🙏❤️🥰
This is so important-
#medtwitter
knows about MIS-C but a lot of non-medical families don’t. Help inform families.
#COVID
-19 is not aways mild for kids. ~6,000 cases and rising of MIS-C in US. As COVID cases go up, so will
#MISC
.
Eager to start Phase 2 study to see if we can improve care for children with
#MISC
following
#COVID19
by blocking GI leak of SARS-CoV-2 particles into blood
@mghfc
@MGH_RI
$NMTR's candidate larazotide will be evaluated as a potential therapy for
#COVID19
-induced MIS-C, a rare but serious pediatric condition, in a Ph 2a trial run by the European Biomedical Research Institute of Salerno, 🇮🇹 & led by
@LaelYonker
M.D.
@mghfc
:
At
#NACFC2023
loving:
- seeing colleagues and friends from near and far
- hearing about exciting progress
- learning of new priorities/tackling new challenges
- the Phoenix weather ☀️
Vaccines protect against symptomatic COVID in kids. (But titers wane!)
Here, we show BNT162b2 induces robust cross-variant SARS-CoV-2 immunity in children despite lower vaccine dose.
Time to vaccinate/boost kids for the winter season!