Jacob Smith @JacobSmithSci Twitter profile

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Jacob Smith

3 months

⏰️ Are you looking to start a PhD? Interested in circadian rhythms & inter-organ crosstalk? Up for living in Barcelona? (who isnt?). If 3 yes's, get in touch via my website (link in bio). Shares/RTs appreciated 🙏 #circadian #interorgan #metabolism #liver #muscle #PhD #newPI

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Jacob Smith

@JacobSmithSci

1 year

Very happy to see our new story out in @CellReports ! Led by myself and @chewinclock , we look at how liver and muscle clocks function independently (and together) to control glucose metabolism. Tweet 1/n #circadian #muscle #liver #metabolism #myotwitter

Liver and muscle circadian clocks cooperate to support glucose tolerance in mice

Smith et al. rescued circadian clock function in liver and muscle in otherwise clock-less mice, finding that glucose tolerance is achieved only when feeding rhythms and Bmal1 function in liver and...

www.cell.com

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Jacob Smith

@JacobSmithSci

1 year

Now online @molcellprot - we show a stronger role of local clocks vs feeding to support liver & muscle proteomes (zt16). Special thanks from myself + @chewinclock to @JeffMolendijk & @Ben_Leo_Parker Lab for great #proteomics ! #circadian #liver #myotwitter

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Jacob Smith

@JacobSmithSci

3 years

Out today in @ScienceAdvances - massive thanks to all involved at UCI and beyond! @sassonecorsilab Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabo...

The inner workings of the clock system rely on communicating signals between distal tissues to maintain daily metabolism.

www.science.org

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Jacob Smith

@JacobSmithSci

4 years

Paolo was a great mentor in the 2 years I spent under his guidance, pushing me whilst allowing freedom in my work. He was genuinely excited to talk science, every day. A really sad loss for his friends and family, UC Irvine, and the scientific community

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Jacob Smith

@JacobSmithSci

9 months

I'm happy to be part of the editorial board for #npjMetabHealth , an exciting new Open Access journal focussed on all things metabolism. Check out the first few papers online, upcoming collections, and how to submit! .

npj Metabolic Health and Disease

npj Metabolic Health and Disease is an online Open Access journal dedicated to publishing high-quality peer-reviewed content on all aspects of metabolism. We ...

www.nature.com

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Jacob Smith

@JacobSmithSci

3 years

How to celebrate a publication during the Covid era

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Jacob Smith

@JacobSmithSci

1 year

Los relojes circadianos del músculo y el hígado controlan el metabolismo de la glucosa

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Jacob Smith

@JacobSmithSci

5 years

Now online! “Clock-in, clock-out: circadian timekeeping between tissues” @PPPublishing @BiochemSoc @sassonecorsilab

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Jacob Smith

@JacobSmithSci

2 years

"Analyse RNA-seq data without writing a line of code" you say? I'm listening !

Guy Teichman

@GuyTeichman

2 years

I'm SO EXCITED to share our new pre-print! 🥳 You finally got your RNA-seq data. You open RStudio, stare at the screen for 5 mins...And realize you don't even remember how to import a table. How will you analyze your data?!😱We're here to help! A 🧵👇(1/9)

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Jacob Smith

@JacobSmithSci

1 year

@vale_eentina spreading the word about the importance of circadian rhythms at #OpenPRBB 2023

UPF Medicine and Life Sciences

@UPFbiomed

1 year

@UPFBarcelona @the_prbb @robertclab @Synbio_Lab_UPF I la @valen_n_tina_ explica per què és millor dinar a les dues del midia que a les dues de la matinada! Els responsables són els ritmes circadians! 😉⏰️🥗 #OpenPRBB

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Jacob Smith

@JacobSmithSci

1 year

Lastly, a sincere thanks 🙏 from Kevin ( @chewinclock ) and I to everyone involved! @masrilab @sassonecorsilab ( @UCIrvine ) @AznarLab ( @IRBBarcelona ) Muñoz Lab ( @UPFbiomed ). @Ben_Leo_Parker @paul_petrus @Mortimert91 @mireiavaca @vale_eentina @PengLiu77127054 (+the twitterless 👍)

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Jacob Smith

@JacobSmithSci

4 years

Great review out in Science authored by Kevin Koronowski and Paolo Sassone-Corsi. Paolo is dearly missed but his scientific legacy continues @sassonecorsilab

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Jacob Smith

@JacobSmithSci

3 years

Check out the latest @sassonecorsilab #bioRxiv addressing the role of autonomous muscle and liver clocks in vivo:

Interrogating Metabolic Interactions Between Skeletal Muscle and Liver Circadian Clocks In Vivo

Expressed throughout the body, the circadian clock system achieves daily metabolic homeostasis at every level of physiology, with clock disruption associated with metabolic disease ( [1][1] , [2][2]...

www.biorxiv.org

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Jacob Smith

@JacobSmithSci

1 year

Using myofiber-specific Bmal1 rescue in otherwise clockless mice, we show the muscle clock can oscillate alone (Muscle-RE), but is phase advanced with reduced amplitude versus wild type. The simultaneous restoration of the liver clock (Liver-Muscle-RE) didn't help. Tweet 2/n

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Jacob Smith

@JacobSmithSci

2 years

Super interesting- entrainment of glucose rhythms in humans in absence of changes of SCN clock activity, suggesting role(s) of peripheral clock(s) Human glucose rhythms and subjective hunger anticipate meal timing

Human glucose rhythms and subjective hunger anticipate meal timing

Isherwood et al. compare the effect of regular large- versus small-meal schedules in humans using high-resolution glucose monitoring and hunger scores. Glucose concentration lowers in anticipation of...

www.cell.com

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Jacob Smith

@JacobSmithSci

1 year

Super interesting #circadian preprint from @DrBatmo @ONeill_Lab !

Andrew (Batmo) Beale

@DrBatmo

1 year

I've put my take on a cellular basis model of the nocturnal to diurnal switch in mammals, to @biorxivpreprint . Here we go!

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Jacob Smith

@JacobSmithSci

1 year

🚨 Open postdoctoral position in the Lab of Paul Petrus @paul_petrus Karolinska @karolinskainst #circadian #metabolism #neuroscience please share and retweet 🙂

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Jacob Smith

@JacobSmithSci

2 years

This is awesome, I would vote for for Pavel's idea for fair and open author recognition in articles

Oded Rechavi

@OdedRechavi

2 years

Love it or hate it? Please share & give feedback! @PavelTomancak and I have an idea that could radically change how science papers are written so we know exactly who thought of each idea, who ran each experiment, and who analyzed the data 🧐🔥👇 @NatRevMCB

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Jacob Smith

@JacobSmithSci

5 years

Oct'19 @sciencemagazine (Tyagarajan, Robles & Brown Labs). Circadian clocks control oscillations in synaptic RNA but local translation and PTMs need intact sleep-wake cycle Acute influence on brain function for shift workers? #circadian #neuroscience

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Jacob Smith

@JacobSmithSci

10 months

@MViggars @GraphPad No but thanks as I'll avoid the new update for now ... 😅

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Jacob Smith

@JacobSmithSci

1 year

But what happens at the functional level in these liver, muscle or liver muscle dual clock restored mice? A partial rescue of local glucose metabolism (please read the paper 🙂) but systemic glucose tolerance is the same as KO (or worse) 6/n

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Jacob Smith

@JacobSmithSci

1 year

So are these clocks doing anything at the systemic level? Well, yes- but only when a feeding fasting rhythm is present (de novo introduced using dark phase-restricted feeding) 7/n

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Jacob Smith

@JacobSmithSci

1 year

This was work we initiated in the great environment of @sassonecorsilab @UCIrvine , also thanks to a fantastic collaboration with @AznarLab @IRBBarcelona & Patrick Welz (now @hospitaldelmar ) who generated these models (and collected some of the samples!) 🙏

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Jacob Smith

@JacobSmithSci

1 year

@LeadSculpt @ameliajimsan @carret_celine @AidanBudd @LifeSciLearn @FrederikeWinkel @CoanMichela @ClaudiaAloisi1 @AnnaSECuomo @LarissaKruger93 @simone_giaveri @vale_eentina For me, probably prioritisation by plotting tasks on the important (y axis) urgent (x axis) graph. And also tips on how to give and receive feedback. Thankfully no conflicts (at least that I'm aware of) to manage right this second

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Jacob Smith

@JacobSmithSci

3 years

@ar888 Thanks Antonella! Even including all the circadian harvests, I spent much less time doing experiments in the dark than I did for biotin-switch, which was a plus!

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Jacob Smith

@JacobSmithSci

1 year

@CellReports Find a mini summary of our key findings here:

Jacob Smith

@JacobSmithSci

1 year

Very happy to see our new story out in @CellReports ! Led by myself and @chewinclock , we look at how liver and muscle clocks function independently (and together) to control glucose metabolism. Tweet 1/n #circadian #muscle #liver #metabolism #myotwitter

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Jacob Smith

@JacobSmithSci

1 year

@simone_giaveri @Joule_CP @Shan2_Luo @erblabs @mpi_marburg Amazing cover art

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Jacob Smith

@JacobSmithSci

1 year

@palomasocas @NatureAging Congrats Paloma!! 🎉🏆

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Jacob Smith

@JacobSmithSci

1 year

@s8shogo @chewinclock @sassonecorsilab @altos_labs @TAMU_Biology @TAMU_CBCR Congrats Shogo, glad to see this out! And perfect synchronisation!

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Jacob Smith

@JacobSmithSci

5 years

@ar888 @rkuruvi1 @SamerHattar @cloutier_jf @LucaCrepaldiDNA @nottalexi @Jacobanderson87 The seaside is a smart choice for the Christmas outing due to the lower chances of getting lost. Hope you had fun- I miss you guys... and British pubs

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Jacob Smith

@JacobSmithSci

1 year

@masrilab @CellReports @chewinclock A massive thanks Selma for all your support and valued contributions from you and your lab to the paper! This was some journey we went on with this one as you know, very pleased with the finish!! Another @sassonecorsilab story to be proud of

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Jacob Smith

@JacobSmithSci

4 years

3'UTR remodelling in the axons of sympathetic neurons is necessary for local protein synthesis. Congratulations Catia Andreassi and the Riccio Lab @ar888 @CellReports

Antonella Riccio

@ar888

4 years

Our paper on the processing of 3'UTRs in axonal transcripts is now out with the beautiful Catia's picture on the cover! @rkuruvi1

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Jacob Smith

@JacobSmithSci

1 year

And a (better late than never) twitter thanks to @cholsoon_jang of course for performing the 13C metabolite fate mapping! 😎🙏

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Jacob Smith

@JacobSmithSci

1 year

@Ben_Leo_Parker Thanks Ben! It was a pleasure to work with the Parker lab!

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Jacob Smith

@JacobSmithSci

9 months

@CterminiPhD mostly drum and bass 😆, rising in intensity as it gets closer to the deadline/I get more tired

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Jacob Smith

@JacobSmithSci

11 months

Linked metabolic and transcriptional cycles- without cells. Nice work @simone_giaveri and colleagues!

Simone Giaveri

@simone_giaveri

11 months

Very excited to share my Metabolic and Genetic Linked in vitro Network (MGLN) that self-integrate in vitro, now on @biorxivpreprint !🥳Great collaboration with @nitinbohra3 , @Chrizzly_92 , @martine_balling , Nicole, Timo, and Tobi Erb @erblabs @mpi_marburg !

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Jacob Smith

@JacobSmithSci

1 year

@paola_tognini @molcellprot @chewinclock @JeffMolendijk @Ben_Leo_Parker Thanks Paola! Really big credit to @Ben_Leo_Parker Lab for proteomics analysis and @chewinclock (Koronowski Lab) for FGF1 characterisation

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Jacob Smith

@JacobSmithSci

8 months

@IvaZovkic @npp_journal @Gildastefy @MagosBiologis @pjmurphy249 @FiryalR @brimmmers Congrats! Super interesting

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Jacob Smith

@JacobSmithSci

1 year

And all this is happening as the absence of feeding-fasting rhythms as there is no clock in the SCN in the RE mice (we look at what happens if you bring back just that clock here- ). 5/n

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Jacob Smith

@JacobSmithSci

2 years

Very cool

De novo design of luciferases using deep learning

Nature - A deep-learning-based strategy is used to design artificial luciferases that catalyse the oxidative chemiluminescence of diphenylterazine with high substrate specificity and catalytic...

www.nature.com

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Jacob Smith

@JacobSmithSci

2 years

@masrilab @ScienceAdvances @UCIrvineSOM @UCIrvine Congratulations! Super interesting data

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Jacob Smith

@JacobSmithSci

2 years

Great opportunity for PhD and postdocs interested in immunometabolism

Laura Surace

@surace_laura

2 years

🔴 lab opening 🔴 It is finally official! I am very very happy to announce that the #SuraceLab is officially open. This is thanks to the support of the MaxEder Grant by @Krebshilfe_Bonn . 🚨 Phd and PostDoc positions soon available🚨 @UniBonn ..stay tuned!

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Jacob Smith

@JacobSmithSci

1 year

Genome wide, we find that the liver itself is more rhythmic in regards to number of 24h oscillating transcripts than muscle, and also that the local clock in liver successfully restores rhythmicity of more transcripts than the local clock in muscle 4/n

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Jacob Smith

@JacobSmithSci

1 year

@palomasocas @AznarLab @IRBBarcelona Best of luck for the future Paloma!!!

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Jacob Smith

@JacobSmithSci

2 years

@emily_h_b @vueling Similarly, I received the following, for a flight next wk. How long do I need to wait to see alternatives? .."inform you that, due to strike reasons, your flight ... will not operate. We will contact you again shortly to inform you of the best alternative for your flight"

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Jacob Smith

@JacobSmithSci

1 year

How is this occurring? See the paper for our initial suggestions (improved transcription of glucose related genes in both tissues, plus improved pyruvate/lactate processing by the liver). Now we're looking for the exact mediators 🧐 🤞 tweet 8/9

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Jacob Smith

@JacobSmithSci

1 year

Would pay to see this

Curious Refuge

@CuriousRefuge

1 year

We made a #StarWars trailer in the style of #wesanderson hope you guys enjoy it!

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Jacob Smith

@JacobSmithSci

7 months

@EBrookesNeuro Congrats Em!! 👏 🔥🔥🔥

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Jacob Smith

@JacobSmithSci

1 year

@Mortimert91 @chewinclock Thanks Tom! Aka dryR master💪😆

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Jacob Smith

@JacobSmithSci

1 year

@vale_eentina @CellReports @chewinclock Thanks Valentina, and thanks for your help with the hundreds of samples 🤯

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Jacob Smith

@JacobSmithSci

1 year

As we found 10.1016/j.cell.2019.04.025 + 10.1126/sciadv.abi7828, the liver clock can oscillate autonomously (Liver-RE). Overall, it does it better job than the muscle clock. At best, we see minor improvements of liver clock oscillations upon addition of the muscle clock 3/n

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Jacob Smith

@JacobSmithSci

3 years

Carolina Greco, @chewinclock , @masrilab , @MarcusSeldin , Pierre Baldi Lab, @superweili , @lutter_dominik , @DyarKen , Pura Munoz Lab, @SalvadorAznar3

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Jacob Smith

@JacobSmithSci

1 year

@PanasyukLab report a novel role for PI3K as a co-activator of the clock. Impressive work!

Panasyuk Lab

@PanasyukLab

1 year

Finally, our second tweet of 2023 holds super exciting NEWS:) Our story on a non-canonical role of class 3 PIK as a transcriptional co-activator of the circadian clock is out in Nature Cell Biology! One more secret of class 3 PI3K revealed and many more to discover.

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Jacob Smith

@JacobSmithSci

1 year

@MViggars Many thanks for the kind words Mark, and very much looking forward to reading more of your work!

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Jacob Smith

@JacobSmithSci

1 year

@EBrookesNeuro @OwenRackham @unisouthampton @UniofExeter @sotonbiosci Those rhododendrons look AI generated to me 😉

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Jacob Smith

@JacobSmithSci

2 years

@emily_h_b @vueling - and what are the options for refund?

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Jacob Smith

@JacobSmithSci

1 year

@jjkelu @CellReports @chewinclock Thanks Jeff mate, hope you're enjoying the GRC myogenesis conference! Hope to cross paths again soon

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Jacob Smith

@JacobSmithSci

1 year

@DyarKen Jajajaja ¡gracias amigo!

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Jacob Smith

@JacobSmithSci

11 months

@simone_giaveri @biorxivpreprint @nitinbohra3 @Chrizzly_92 @martine_balling @erblabs @mpi_marburg Congrats Simone 👏

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Jacob Smith

@JacobSmithSci

1 year

Incredible study from Lab of Jonathan Long: cell-type specific secretome analysis using 21 (!!) different cre lines with Turbo-ID... also +/- exercise🤯

Organism-wide, cell-type-specific secretome mapping of exercise training in mice

Wei et al. use proteomics to identify cellular secretome changes in response to exercise training at an organism-wide scale. Using this dataset, Wei et al. identified two exercise-inducible secreted...

www.cell.com

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Jacob Smith

@JacobSmithSci

3 years

@AndrewR_Physics @mbeisen I think 1966 is the only time England took part in a world cup right? Could be wrong about this but pretty sure 😉

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Jacob Smith

@JacobSmithSci

2 years

@awkwardbrowngal @emily_h_b @vueling The flight options were emailed after an hour or so, keep refreshing the page as more became available. Good luck

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Jacob Smith

@JacobSmithSci

1 year

@RafaelMoliner @castren_eero Fantastic work, super interesting!

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Jacob Smith

@JacobSmithSci

1 year

@palomasocas @CellReports @chewinclock Thanks Paloma, and congrats on your PhD! 🥇

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