***Hot off the
@JAMANeuro
e-press***
While seeking to investigate clinicopathologic heterogeneity and glial activation patterns of
#Alzheimers
...we created a corticolimbic index (CLix) to better capture the individuality of tangle distribution.
The future has arrived. Despite (or because of) my tumultuous past, I would like to take the opportunity to introduce myself.
I
becAMe
Professor
Melissa
E.
Murray
Est. 2023
Guess who is the 2022 Investigator of the Year
@MayoClinic
in Florida ๐คฉ
Dreams really can come true. Not to say that there may have been a few mountains to climb and glass cielings to break๐ช Huge thank you to my team, collaborators, and mentors ๐ฅณ๐ฅฐ
Sooooo two pretty big things happened to me lately, my Associate Professor status finally went through and I received my first request from a grad student to rotate in my lab. I can't decide which I'm more excited about ๐ฅณ๐
It took nearly 20 years after graduating college to rise through the ranks from technician to full Consultant of
#Neuroscience
, but on this day let it be known that she started from the bottom now sheโs here
#FloridaWoman
#phdlife
Two roads diverged in the woods of
#AlzheimersDisease
where to study amyloid-ฮฒ was almost to the exclusion of tau (and vice versa). I took the road less taken...and until fluid biomarkers could not see the forest for the trees. New pub out with
@MolNeuro
So after triple checking we are not in the 26th percentile, I am ridiculously excited to share with you that
@grinberg_t
, Dino Ghetti, and me have the incredible opportunity to combine forces to tackle young-onset Alzheimer's disease. It is going to be a wild adventure
#endalz
First came science๐ฌ. Then came love. Then came wedding plans. Then came pandemic. Then came cancelled wedding. Then came no reason to wait๐ฅฐ. Now comes happily ever after sciencing and loving...
#MrsPhD
#AcademicChatter
#phdlife
<--- So the girl who struggled for years with linear thinking and scientific writing became a woman who is stunned to learn she is one of this year's
#HighlyCited2020
researchers. Not possible without the team science approach and all the eyeballs wanting to read our work. Whoa๐คฏ
NEWS >> Today we announce our annual Highly Cited Researchers list, recognizing true pioneers in their fields whose highly cited papers rank in the top 1% in the Web of Science. The U.S. still dominates the list but China's share continues to grow:
Apparently there is fun word for when your brain finds neurons in the road...I usually like finding shapes in the clouds, but good to get grounded every now and again ๐
#Pareidolia
Peter Davies you will go down in history for your giving spirit and wonderful laugh. Thank you for your contribution to science, advancement of knowledge, and friendship. You will be missed, but your legacy will endure through the life you bring to the postmortem brain.
Found myself in a conversation where there was surprise of my successes despite my lack of pedigree (i.e. my undergrad). I was not angry, but proud that "despite" all I turned it to fuel. The ladder may be slick and ceilings made of glass, but it is your choice to become a bada$$
JAX > ATL > AMS > GOT
Getting excited for my first plenary at
#ADPD2023
on Thursday๐คฉ Grateful to the organizers for giving me the opportunity to highlight how much
#neuropathology
rocks!
Congratulations to
@jmschott
for his well-deserved receipt of this year's
#AAIC23
Bill Thies Award for Distinguished Service to
@ISTAART
๐๐ we are soooooo proud of you!
I don't know who needs to hear this, but if you email a group of people who all have a doctorate... Either commit to first name familiarity or use Dr. for all
Yes, I am a youngish female PhD that loves clinical research. I do not have an MD, but still went to school for 21 years
(1/X) Wow, we are up to 33 Alzheimer's Disease Research Centers (ADRC). I have scientifically "grown up" embedded in an ADRC and in case you are unfamiliar wanted to share a few resources with you...๐งต
If looking to harmonize brain tissue sectioning across centers or generally looking for a high-resolution
#neuroanatomy
atlas, check out this open-access gem from
@AllenInstitute
๐๐ง
12 hours later๐คฉ very much enjoying the 3D brain printing updates... Apparently glow in the dark though is rough on the printer, so had to go with the next level of ridiculous
While stupid beauracracy kept my postdocs from being able to travel internationally, it warms my science heart to see my grad student present at her first conference. Thank you
#ADPD2022
for giving young scientists the opportunity to share science!!! Tiffany Sirmans Room 114 now
Wheels up for Amsterdamโ๏ธ. First stop a workshop dedicated Alzheimer's disease heterogeneity with
@bettytijms
and
@CharlotteTeuni1
๐คฉ and finally after three long years of waiting
#AAIC23
Amsterdam-style๐ Let me know what science I should not miss๐๐๐
At first I was afraid, I was petrified. Kept hearing I was not smart enough to become the scientist I knew I was inside. But then I spent so many nights thinking how I could prove them wrong. And I grew strong. And I learned about collaboration. Now I thrive๐ช๐ต
Time takes time. 40 years ago I was helping my mom to bed as she fell down drunk. Today. I gave her her 40th
#AA
chip. I am so grateful for all of her dedication and all the people there in the rooms supporting so many through sobriety.
A long journey, but we now present you with some exciting updates to the Alzheimer's disease subtypes saga๐ง
@thefadialshaikh
#ENDALZ
thank you
@JAMANeuro
!
Greater neurofibrillary tangle accumulation found in cholinergic hub (nucleus basalis of Meynert) of hippocampal sparing
#Alzheimerdisease
and young onset Alzheimer disease brains
Was wrapped up in study section on the
#TheLongestDay
, but would be remiss to not share in the fight against the darkness of
#Alzheimer
's disease for all those already lost to us and to ensure in future our loved ones' beautiful brains stay healthy ๐ช๐๐
#ENDALZ
"Find your people"... beautiful words from an incredible scientist. Parabรฉns
@erzimmer
on Blas Fragione Early Career Achievement Award, so very well deserved!!
#AAIC24
Happy
#InternationalWomensDay
๐ Grateful for all the sisterhood and support. Too many to thank for being awesome, so share or tag to amplify the elegance of working toward a future when all our sisters have a voice and we no longer need a day to bring awareness
@BaaylaB
What an amazing & inspiring day. Watched a live screening of Spark documentary that shows the strength and love of Susan Schneider Williams and
#RobinWilliams
through the tragedy of not gaining an accurate Lewy body dementia dx. Lovely lunch after w/ Susan
@DoctorQMd
@dennis_w_d
Fantastic discussion at
#Tau2024
on what we may need to do to consider inflammation in the
#Alzheimers
framework with
@MaluTansey
boldly suggesting we consider rearranging the acronym to iATN ๐
You ever meet someone who you know will help change the world just by existing...then you get to know them and see how much they're actively doing to make a
#betterworld
. Allow me to introduce you to my friend and inspiration for all of our upcoming
#MAPT
projects, Linde Lee๐คฉ
First day back from
#AAIC24
and could not think of a better way to celebrate my birthday than by ensuring progress to defeat
#Alzheimers
. The lab went all out and redecorated my office, I am so blessed. Hope you all enjoy this and make things day of my ๐๐
Soooo, our 5 year long journey to investigate molecular underpinnings of Alzheimer's disease subtypes has finally culminated into a publishable story.
@DrAngelaCrist
and I are trying for Nature...eek! Definite learning curve for manuscript prep.
Week 1 of our adventure
So excited for the
#AAIC2021
plenary by
@MaluTansey
. A leader in the field of innate immunity who was driven to study it before it was in vogue ๐ Compelling evidence for an inflamm-ageing hypothesis.
Moving opening at
#Tau2024
by Linde Jacobs on MAPT families fighting for a future. She and her sisters have already inspired work in my lab on MAPT mutation carriers and I hope her families' galvanizing story inspires more research
I will always remember and never forget you Grandma
#WorldAlzheimersDay
Thank you to all the scientists and clinicians for your tireless efforts, your late nights and weekends, resilience through rejection, and unwavering desire to work together to defeat
#AlzheimersDisease
I dedicate this
#TheLongestDay
to you Grandma. I will keep trying day and night to help
#ENDALZ
so that others will not know the devastation felt when you look into the eyes of a loved one who has forgotten you.
Such a great discussion at today's blood based biomarkers forum. Loved the opportunity to hear key questions asked by such a good looking audience ๐
@OskarHansson9
always a pleasure to co-moderate. Many thanks to the discussants for such a thought provoking discussion!
#ADPD2024
And the
#AntibodyAvenger
award this month goes to the team lead by
@SarahIBEx
and
@irina_stefana
. Large scale evaluation of high-performing antibodies for the reliable detection of
#Tau
proteoforms by Western blotting and immunohistochemistry. Well done ๐๐ง
Interested to learn more about how non-memory forms of Alzheimer's disease (atypical AD) more commonly affect younger individuals...Well look no further! Even more exciting for the next 50 days the article has been made freely available by
@TheLancetNeuro
Fascinated by evidence suggesting phospho-tau fluid
#biomarkers
elevate earlier than tau PET uptake, we embarked on a microscopic adventure hypothesizing phospho sites recognize earlier tangle maturity levels.
@DrChristinaMo
@sydney_labuzan
rocking it!๐ฌ
If you want the opportunity to literally feel scientific enthusiasm, check out
@BaaylaB
poster number 45 to learn how she is leveraging atypical clinical variants to understand spatial neuroinflammation patterns
#AAIC2021
#AtypicalPIA
@AlzheimerAms
Guess who gets to team up the
@RossollLab
for a bold new approach to Next Generation Neuropathology?!?!
---> !!!Murray lab!!! <---
Thank you to the team
@cziscience
for supporting our collaborative pairs project, we look forward to making you proud๐ง
#Neuropathology
#Proteomics
Weโre welcoming 60 new grantees to
@ChanZuckerberg
โs Neurodegeneration Challenge Network! These researchers are piloting innovative approaches to fighting neurodegenerative diseases like
#Alzheimers
,
#Parkinsons
+
#ALS
Guess who is a first time neuropathology core co-leader?!?
---> this lady ๐ฉโ๐ฌ๐ฌ<--
So excited to work with my co-PIs
@grinberg_t
and Dino Ghetti and the LEADS leadership of
@ApostolovaLiana
,
@DrMariaALZ
, Gil Rabinovici, and Brad Dickerson!
@DavidJonesBrain
hope your ready๐จโโ๏ธ
Day 3
#ADPD2024
I feel so hopeful sitting in an audience hearing about therapeutic comparisons with comparator data demonstrating improved amyloid clearance in early symptomatic
#AlzheimersDisease
with no new additional safety findings.
#ARIA
and
#APOE
remain in the forefront of
I don't know what's cuter, that my brother found me
#brain
socks for my birthday or that my childhood nickname now has a doctor in front of it๐ค๐ง ๐ซ But I could not agree more, All you need is lobe๐ฅฐ
Yours truly,
Dr. Moose E. Murray
Getting 3D brains printed for my
#neuronatomy
class. Kind of curious which one they'll want, the fixed looking specimen or the funky/fun looking specimen๐ค๐ง Printing at 50% for transportability
I just learned of a heart breaking loss to science. We go through so many ups and downs that personal crisis is often a tipping point that may feel unable to be endured. Reach out to a friend or colleague today just to say hi, so they know someone is thinking of them.
Looking forward to engaging science atย
#AAIC24
ย and excited for next Tuesday's After Hours reception. Check your registration..if missing go back through and sign up before free tickets get claimed. Hope to see you whether you self-identify as a wall flower or dancing fool๐
"From tragedy to potential therapy" ...Dr. Eddie Lee
@TNRLab
you are a true inspiration. Thank you for remaining hopeful and showing the impact of translational
#neuropathology
๐๐๐
#AAIC24
Congratulations to Parichita Choudhury and Brad Boeve for their recent study highlighting the clinicopathologic heterogeneity of Pickโs disease, a rare 3R-tauopathy.
@Parichita
@mayoneurores
@mayoneurores
Yes please! After 21 years of education it was hard to learn what I would be earning as a postdoc. While I always reminded myself that I was not getting into science for the money, it was hard to watch some of my friends leave science for better paying jobs with less internal
#AAIC22
here I come. Excited to hear everyone's science, see my lab family present
@DrChristinaMo
@BaaylaB
Tiffany Sirmans, and debate
@pedrorosaneto
on the merits of performing Braak stage under the microscope vs. Tau PET... should be a blast!
I love random facts and especially newfound science knowledge. So for a
#FunFactFriday
edition, wanted to share that there is a super rare APOE ฮต1 allele๐ฏ
Proud PI moment๐คฉ Having followed
@SaraRoseDunlop
career since she was a technician with
@grinberg_t
and Bill Seeley...now to see as a first year postdoc such maturity in her presentation style and thoughtful consideration of the science... Sky is the limit for this rising star
Arrived safely to Philly with only a few delays๐ Looking forward to a strong
#neuropathology
presence ๐ช we are gathering for our annual neuropath squad photo at 10:30am on Monday near registration, hoping to find the big
#AAIC24
sign
@grinberg_t
@TNRLab
@theREALaivisaur
Great way to wrap up a week with
#tau
goddess Karen Duff... so much knowledge to be gained on the clinical, cellular, molecular, and conformational diversity of one protein
@Duff_Lab
You ever love working on a study so much that you were not sick of the paper by the time it was submitted๐ค๐คฉ Our preprint is the result of taking someone from the insoluble world (
#neuropathology
) and letting them see
#Alzheimers
from the soluble perspective (
#plasma
)๐ง ๐ฉธ
Found this gem on physiologic roles of tau and Aฮฒ in
#Alzheimers
from
@Sarah_A_Kent
@ClaireDurrant1
@TSpiresJones
Check out figures 5&6 to help keep an open mind on the multiple roles of these proteins prior to their abnormal accumulation ๐ง
Just landed in Gรถteborg and excited for my first Swedish PhD defense by Srinivas Koutarapu. Fascinating research topic on "Amyloid maturation patterns in
#Alzheimer
โs Disease"
Looking forward to seeing you
@neurochem4
@_michael_scholl
The time has finally arrived,
@HAIconference
is back to gather the world's leaders and super fans of
#AlzheimersDisease
imaging & fluid biomarker research
โ๏ธOctober 10 abstract opens
โ๏ธ October 28 abstracts close
โ๏ธ January 11-13 meeting dates in Miami
Proud PI moment... Two of my fantastic postbac fellows just presented at our departmental AD Joint lab meeting. They did such a great job!!
@sydney_labuzan
and
@BillieJMatchett
you gals rock๐ค
Grateful for virtual opportunities like these to help propel our trainees forward!
Watch out world Dr. Henika Patel has flawlessly earned her PhD. Fantastic mentorship by
@LasagnaLab
and
@pbmartinc
coupled with
@PatelHenika
passion for science made for an engaging defense of her work. Brava๐๐๐
Attending
#CTAD22
for the first time and off to a great start. Well-deserved standing ovation for Reisa and Keith's lifetime achievement, followed by hot off the press
#lecanemab
data.
The Appropriate Use Criteria (AUC) for Amyloid and Tau PET Imaging is out for public comment until February 26th. So much progress was made by the field while working on this AUC!
Welcoming your feedback:
Grateful for the opportunity to participate with
Such a good looking audience๐คฉ Thank you for staying so late to hear us wax poetic on Braak staging.
@pedrorosaneto
very much enjoyed debating with you.
#AAIC2022
@bettytijms
Christina Young great job organizing!
Come join us at
#AAIC20
for a lively multi-disciplinary featured research session on Neurobiological subtypes of AD
Tuesday 8:30-9:30 (U.S. Central) live presentations and Q&A
Co-chairing with Eric Westman
Great speaker lineup Michel Grothe,
@bettytijms
, Daniel Ferreira