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RikOssenkoppele

@RikOssenkoppele

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Neuroscientist | Alzheimer's disease | Dementia | PET, MRI, Fluid biomarkers | Cognition | Associate Professor @AlzheimerAms & @lunduniversity

Amsterdam, The Netherlands
Joined June 2010
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@RikOssenkoppele
RikOssenkoppele
@RikOssenkoppele
6 months
The Alzheimer's disease 2024 drug development pipeline An often heard critique is that the Alzheimer field is too “amyloid-centric”. The Figure below actually shows a well-diversified drug pipeline, which is highly needed. The mechanisms of action (CADRO) for agents currently
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@RikOssenkoppele
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1 year
What an amazing honor to be giving the opening plenary on tau PET at #AAIC23 !
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3 years
Nice overview of the current Alzheimer's disease drug development pipeline, .
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2 years
Are #Amyloid and #Tau #PET positive cognitively unimpaired individuals destined to decline? Find out in our new preprint: . See a thread👇1/11
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4 years
Must read for all researchers and clinicians in the field of #Alzheimer 's: "Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials", . @JNNP_BMJ
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3 months
The figure we all have to learn by heart: The updated Lancet Commission on potentially modifiable risk factors for dementia. #AAIC24
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4 years
Delighted to announce that I have received an @ERC_Research starting grant ( #ERCStG ) for the project “TAU-NOW”, in which we will investigate the #spreading of and #resilience against #tau pathology in #Alzheimer ’s disease. @biofinder_study @lunduniversity @AlzheimerAms
@ERC_Research
European Research Council (ERC)
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4 years
NEWS: ERC Starting Grants worth €677 million awarded to 436 excellent early-career researchers. Discover the details. #ERCStG 🇪🇺 #EUfunded
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6 months
A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution Just published in Science. This is spectacular work! The authors obtained a 1 mm3 sample of the human temporal cortex from an individual undergoing epileptic surgery. This sample was then
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3 years
Very pleased to present the first (research) #criteria for the behavioral variant of #Alzheimer 's disease, based on systematic review and meta-analysis of the literature: . @JAMANeuro @AlzheimerAms @UCSFmac @RabLab_UCSF @AlzheimerEMC @ZonMw
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2 years
Thanks to the @alzassociation for the invite to give a plenary talk at #AAIC23 on tau PET in my hometown Amsterdam!
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4 years
Fantastic work by @_JakeVogel_ who identified four distinct trajectories of #tau deposition identified in #Alzheimer ’s disease, . @NatureMedicine @biofinder_study @OskarHansson9 @UCSFmac @relajoie @NeilOxtoby @MedinYasser .
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3 years
What an honor to receive the Queen Silvia Research Prize from HM at Drottningholm Palace in Stockholm! Big congratz to co-recipient @NicholasAshton and many thanks to Alzheimerfonden and to my brilliant colleagues @biofinder_study , @AlzheimerAms & elsewhere!
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1 year
Exciting presentation of the phase 3 Donanemab results. Very effective removal of amyloid-beta pathology, a modest slowing of cognitive decline, but NO impact on tau PET signal over time (!). #AAIC23
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3 years
NEW: We discuss a probabilistic model of #Alzheimer 's disease as an alternative to the deterministic amyloid cascade hypothesis, . @NatRevNeurosci
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6 months
When does Alzheimer’s disease start? (i.e., their provocative title, not mine) Recent preprint at Lancet Neurology The main results of this large-scale analysis across 3 cohorts (n=1,088 w/4,383 Amyloid PET scans): 1⃣ There is a time window of ~16.5 years between crossing the
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2 years
Our meta-analysis @BiolPsychology revealed significant anatomical overlap between behavioral variant frontotemporal dementia ( #FTD ), schizophrenia, bipolar disorder & autism spectrum disorder: . @AlzheimerAms @Colin__Groot @bettytijms @PhilipAlz @FBarkhof
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4 months
Multifaceted roles of APOE in Alzheimer disease Review summarizing the state-of-the-art literature on APOE and the potential of APOE-directed therapeutics. Link >
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6 months
Should APOE ε4/ε4 be considered a genetic form of AD? Just published at Nature Medicine. "By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive amyloid scans, with the prevalence of these markers increasing with age, indicating
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4 years
NEW IWG criteria @TheLancetNeuro : "We recommend that #Alzheimer ’s disease diagnosis be restricted to people w/positive biomarkers & specific AD phenotypes, while biomarker+ cognitively unimpaired individuals are considered at- #risk for progression to AD".
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3 years
Very proud to present our @medrxivpreprint including the first-ever research #criteria for the behavioral variant of #Alzheimer 's disease, . @EllenSingletonn @jannepapma @PhilipAlz @UCSFmac @RabLab_UCSF @AlzheimerEMC @AlzheimerAms
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3 months
The median time interval between becoming Tau PET positive and developing dementia is ~7 years and no T+ participant remained dementia-free after 15 years.
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3 years
Pleased to share our multicenter study in >1400 persons across the #Alzheimer 's disease spectrum, showing that #tau #PET is a promising #prognostic marker in #preclinical and #prodromal AD - outperforming #amyloid PET and #MRI , @JAMANeuro @OskarHansson9
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3 years
Our first preprint of 2022: " #Amyloid -associated increases in soluble #tau is a key driver in accumulation of tau aggregates and cognitive decline in early #Alzheimer ", . co-lead by @alexa_pichetb & @nfranzme , w/ @OskarHansson9 @biofinder_study and others.
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3 months
It was pleasure to present our head-to-head comparison between plasma p-tau217 and Tau-PET for predicting future cognitive decline in >1500 cognitively unimpaired individuals from 9 cohorts. #AAIC24
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2 years
Incredibly proud to share our latest work published @NatureMedicine , . Many thanks to all authors and cohorts ( @biofinder_study , @AlzheimerAms and others) for making this work possible, especially @alexa_pichetb , @Colin__Groot , Cliff Jack & @OskarHansson9 .
@biofinder_study
BioFINDER
@biofinder_study
2 years
The @biofinder_study is proud to present our latest paper by @RikOssenkoppele , @alexa_pichetb et al. published in @NatureMedicine today! Link (open access): Thread below 👇
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1 year
🚨NEW: our paper “ Interactions between #vascular burden and #amyloid -β pathology on trajectories of #tau accumulation” led by @EmmaCoomans is now published @Brain1878 . @biofinder_study @AlzheimerAms @OskarHansson9
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5 years
I'm very proud to have received the Christopher Clark Award at #HAI2020 ! It was extra special because my dear friend @_JakeVogel_ got the Young Investigator Award. Many thanks to all my colleagues and this great research community. @HAIconference @biofinder_study @AlzheimerAms
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4 years
FDA approval for Flortaucipir ( #tau ) PET!
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2 years
This is the Alzheimercenter Amsterdam! #AAIC22 @AlzheimerAms
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1 year
Still overwhelmed by all the kind words after my plenary at #AAIC23 yesterday, thank you all! Also, many thanks to the @alzassociation (especially @claire_e_sexton ) for facilitating that my wife and parents could attend.
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5 months
A lipidome atlas of the adult human brain Link > @NatureComms
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3 years
More evidence that #plasma p-tau differentiates between #Alzheimer 's disease and frontotemporal lobar degeneration ( #FTLD ), with p-tau217 > p-tau181. @TheLancetNeuro @UCSFmac
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3 years
NEW @Brain1878 : @EmmaCoomans showed that identical #twins had comparable #tau load and distributions, highlighting the important role of #genetic factors in early accumulation & spreading of tau pathology, . @Brain1878 @AnoukBraber @PhilipAlz @AlzheimerAms
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3 years
Looks interesting: "The human #connectome in #Alzheimer disease — relationship to #biomarkers and #genetics " by @meichen_yu , @spornslab and Andy Saykin. , @NatRevNeurol .
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3 years
Our latest work shows differential #FDG #PET trajectories across cognitively-defined #Alzheimer ’s disease subgroups", . @AlzheimerAms @Colin__Groot @RisacherShannon @PhilipAlz @pcrane_paul
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2 years
📌NEW PAPER @Brain1878 : Proud to present our multicenter study "Determinants of cognitive and brain #resilience to #tau pathology: A longitudinal analysis" led by Diana Bocancea. @biofinder_study @AlzheimerAms @RabLab_UCSF @relajoie @OskarHansson9
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2 months
Proteomic changes in Alzheimer disease associated with progressive Aβ plaque and tau tangle pathologies Very elegant work from @biofinder_study , led by @alexa_pichetb , @_JakeVogel_ & @OskarHansson9 . Link at @NatureNeuro >
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4 years
Pleased to share our diagnostic study using the #tau #PET tracer [18F]RO948 in 613 participants with a variety of clinical syndromes, led by @AntoineLeuzy : (open access). @JAMANeuro @biofinder_study
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5 months
Physical exercise, cognition, and brain health in aging Key takes: 1⃣ The effects of exercise on cognition are mediated, in part, by structural and functional adaptations in the brain, including changes in gray matter volumes and white matter microstructural integrity. 2⃣
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8 months
🚨 NEW: @IsmaelLCalandri shows that Argentina has a higher population-attributable fraction (PAF) for dementia + different risk factor weights vs worldwide estimates. PDF: w/ @Gill_Livingston @reparadela @luCrivelliOk @NeuroAllegri @clausuemoto
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1 year
A clinico-pathological masterclass by Marsel Mesulam about primary progressive aphasia in Alzheimer’s disease. #AAIC23
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4 years
Proud to share our #PET and #autopsy work on #tau pathology in the behavorial variant of #Alzheimer 's disease @JNNP_BMJ by @EllenSingletonn . @AlzheimerAms @UCSFmac @biofinder_study @AlzheimerEMC @relajoie @OskarHansson9 @RabLab_UCSF @PhilipAlz @jannepapma @DrAnkeDijkstra @ZonMw
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3 years
Just submitted a review w/ @rikvanderkant & @OskarHansson9 on #plasma , #CSF and #PET biomarkers of #tau pathology in #Alzheimer 's disease and their utility for clinical practice and trials. Here's a sneak peek, image credits to @david_berron , @_JakeVogel_ and Olof Strandberg.
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4 years
NEW: we show that the protective effect of #APOE -ε2 against developing clinical #Alzheimer 's is primarily linked to #resistance against #A β rather than #tau pathology. Congratz @gesalbla and Michel Grothe! w/ @_michael_scholl @AlexisMoscoso9 @JuandoGispert
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5 years
When stem cell researchers ( @alzheimerondrzk and Larry Goldstein) and neuroimagers (me) meet. Check our review “ #Amyloid -independent regulators of #Tau pathology in #Alzheimer ’s disease” @NatRevNeurosci ! @AlzheimerAms
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5 years
Working from home...
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Lecanemab attenuates the rate of tau (PET) accumulation. #AAIC24
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4 months
Revised criteria for diagnosis and staging of Alzheimer’s disease The criteria will obviously have a profound impact on the field. Couple of key points: 1⃣ Alzheimer's disease is defined as a biological process that begins with the appearance of AD neuropathologic change while
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1 year
Great to see our paper on determinants of cognitive and brain resilience agaist tau pathology being published! @AlzheimerAms @biofinder_study @RabLab_UCSF @UCSFmac @OskarHansson9
@Brain1878
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1 year
Bocancea et al. investigate the factors that allow some individuals to maintain intact brain structure and cognitive performance despite abundant tau pathology.
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Today is a special day: we celebrate the impactful career of @PhilipAlz with a symposium and his valedictory lecture. Thanks for everything Philip!
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5 months
Key milestones in AD research Great Figure, but I am really missing the discovery of Aβ (and Tau) PET and plasma p-tau. 1⃣ These markers have taught us a lot about disease progression in AD. 2⃣ We would not be able to run efficient clinical trials without them. 3⃣ The Aβ
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3 years
NEW: @OskarHansson9 and I argue that #tau #PET can improve the differential diagnosis of #dementia syndromes where #Alzheimer disease is among the major possible underlying diseases, ( @alzdemjournals ). Agree or disagree?
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🚨 NEW PREPRINT! "Prediction of future cognitive decline among cognitively unimpaired individuals using measures of soluble phosphorylated tau or tau tangle pathology" I am very pleased to present our most recent work! It concerns a large multi-cohort study in which we
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5 years
Pleased to share our article "Assessment of Demographic, #Genetic , and #Imaging Variables Associated With Brain and Cognitive #Resilience to Pathological #Tau in Patients With #Alzheimer Disease" @JAMANeuro , . @biofinder_study @UCSFmac
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3 years
Check out this authoritative review by @OskarHansson9 on #biomarkers of #neurodegenerative diseases, published today @NatureMedicine : .
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2 years
Cognitive reserve has been boosted, now fully ready for day 2 of #AAIC22 ! W/ @jmschott , @OskarHansson9 and Henrik Zetterberg.
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1 year
Dear Twitter friends. Please help @vermeiren_marie and me with completing this survey on the use of #tau #PET in clinic and trials. The results will be used in my #AAIC plenary and eventually published. Please also SHARE and/or RETWEET!
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“The future role of tau PET in clinical practice and trials” - Alzheimercentrum Amsterdam

Delen In the rapidly evolving field of Alzheimer’s Disease biomarkers, scientists strive to improve trial designs and diagnostic processes in clinical practice. With...

www.alzheimercentrum.nl
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The implications of Aβ pathology: Only time will tell 🚨 Our scientific commentary is just out in Brain! @EmmaCoomans and I had the privilege to write an editorial on the recent publication "Characterizing brain tau and cognitive decline along the amyloid timeline in
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What an excellent PhD defense of an extraordinary thesis yesterday! Proud and pleased that @EmmaCoomans will continue as a postdoctoral researcher on my @ERC_Research project TAU-NOW. @AlzheimerAms
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2 years
Great plenary by Thomas Beach about neuropathology in the era of biomarkers. #AAIC22 (And I got lucky capturing the transitioning of slides)
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4 years
Grateful to the Dutch Alzheimer foundation ( @alzheimernl ) for receiving the Young Outstanding Researcher award! A great boost for our research. Many thanks to all collaborators over the past years and congratz to the other winner, @RensBrankaert .
@alzheimernl
Alzheimer Nederland
@alzheimernl
4 years
Voor de 3e keer reikten wij de Young Outstanding Researcher Award uit aan twee jonge, talentvolle onderzoekers. En de winnaars zijn... @RensBrankaert ( @Center_HT en @Fontys ) en @RikOssenkoppele ( @alzheimerams ). Van harte gefeliciteerd met de #YORaward ! 👉
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9 months
Great to see our large multi-cohort, @UCSFmac -led, study published @TheLancetNeuro (open-access)! It shows that the clinical phenotype "posterior cortical atrophy [PCA]" is highly specific for #Alzheimer 's disease pathology.
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Check out our detailed characterisation of the right temporal variant of frontotemporal dementia @Brain1878 , ! Great work by Hulya Ulugut Erkoyun @AlzheimerAms . @PhilipAlz
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2 years
Some highlights from a terrific multimodal neuroimaging session covering tau spreading, neuroinflammation, diaschisis, twin design to test causality and tau PET vs plasma p-tau comparisons. #AAIC22
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@RikOssenkoppele
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Harmonizing tau PET in Alzheimer’s disease: The CenTauR scale and the joint propagation model A first step towards a Centiloid equivalent for Tau PET. Great to see this published; I really enjoyed the discussions with the Working Group (and look forward to the next steps).
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3 years
Excellent first plenary talk by Henrik Zetterberg, who provided a great summary of the major developments with respect to #CSF and blood-based #biomarkers in #Alzheimer 's disease (and other neurodegenerative disorders). #AAIC2021
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2 years
Although they are delicious and beautifully designed, I look forward seeing my girls in vivo - rather than in cappuccino. Heading back to Amsterdam now, thanks everyone for a fantastic #AAIC22 !
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6 months
Cognitively healthy centenarians have lower AD polygenic risk scores. The genetic effects for maintaining cognitive health until extreme ages were specifically concentrated on genes associated with the endolysosomal and immune system (i.e., alleles in/near ANKH, GRN, TMEM106B,
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4 years
I'm very honored to be part of this fantastic line-up for a symposium about #tau accumulation and progression (tomorrow [Tuesday] at 11:30am CDT). I will discuss evidence from the tau #PET literature and some of our ongoing/unpublished work. #AAIC20 @biofinder_study @AlzheimerAms
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2 years
What a pleasure to host @bucklr01 and @nfranzme in Amsterdam! Very much looking forward to our future project(s).
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1 year
Reisa Sperling showing the A4-study neuroimaging results, showing that solanezumab did not lower amyloid levels (slide 1), hence tau PET signal kept increasing (slide 2) and cognition went down, especiallly in the highest amyloid tertile (slide 3). #AAIC23
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2 years
On the day of the Aducanumab FDA approval I went for a long run to contemplate my lack of enthusiasm regarding this milestone, but today I am genuinly excited about the #lecanemab phase III outcome! (And curious to see more data @CTADconference )
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2 years
Check our our latest @medrxivpreprint led by @gesalbla , . "Specific associations between #plasma biomarkers and post-mortem #amyloid plaque and neurofibrillary #tau tangle loads" w/ @NicholasAshton , @OskarHansson9 @biofinder_study and many others.
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1 year
It was a pleasure to write this editorial together w/Wiesje vd Flier @JAMANeuro Key sentence: "While assessment of APOE status has never been an ancillary diagnostic test in the clinical workup of AD, this is likely to change in the dawning era of disease-modifying treatment."
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1 year
And another impressive plenary lecture on the role of complement in Alzheimer’s disease by Cynthia Lemere. Very good basic neuroscience session today at #AAIC23 !
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1 year
And after a talk (in Dutch (!)) at the public session organized by the Dutch Alzheimer Association ( @alzheimernl ) #AAIC23 has now ended…! What an fantastic week it has been, thanks everyone and have a safe trip back home!
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Nick Fox making the case that excess brain volume loss associated with Lecanemab (or other effective mAB’s) is associated with the removal of “space-occupying” structures, as amyloid plaques occupy ~6-8% of the cortex in autopsy studies. #AAIC24
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3 years
Pleased to share our latest work showing that #Tau #PET correlates with different #Alzheimer ’s disease-related features compared to #CSF and #plasma p-tau biomarkers, . @EmboMolMed @biofinder_study @AlzheimerAms @NiklasMattsson4 @PhilipAlz @OskarHansson9
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5 months
Pleased to present our latest work "Tau PET for predicting dementia in individuals with MCI", led by @Colin__Groot ! Open access link @JAMANeuro > @SEMastenbroek @EStomrud @alexa_pichetb @AntoineLeuzy @SebastianPalmqv @NiklasMattsson4 @VGaribotto
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4 years
New @medrxivpreprint by @EllenSingletonn : Multicenter study ( @AlzheimerAms , @biofinder_study , @UCSFmac )shows heterogeneous distribution of #tau pathology ( #PET and #autopsy ) in the #behavioral variant of #Alzheimer 's disease.
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2 years
New study estimates a global prevalence of 416 million people across the #Alzheimer 's disease continuum (32M w/AD dementia, 69M w/prodromal AD, and 315M w/preclinical AD), . @alzdemjournals @JeanGeorgesAE @MaTeFerretti @AlzheimerAms .
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4 years
I JUST GOT THREE PAPERS ACCEPTED @nature !
@realDonaldTrump
Donald J. Trump
@realDonaldTrump
4 years
I WON THE ELECTION!
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1 year
This is Team Alzheimer! We ran 16.1km and raised €20K for research into the genetic underpinnings of Alzheimer’s disease. Well done all!
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2 years
On my way to my second home for @CTADconference , looking very much forward to it!
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1 year
Below is an opportunity to provide feedback on the updated NIA-AA criteria, presented today by Cliff Jack at #AAIC23 . NIA-AA Revised Clinical Guidelines for Alzheimer’s | AAIC
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5 years
Happy to announce that I have been elected as program chair for the @ISTAART #AtypicalPIA ! I will give it my best to make an impact for this under-recognized and -studied group.
@DrNeuroChic
Prof. Melissa E. Murray 📸🔬
@DrNeuroChic
5 years
#AtypicalPIA elections are now open with an impressive candidate list! @ApostolovaLiana , Jennifer Whitwell, @cfredericksmd , @conyike , @RikOssenkoppele , Sandra Weintraub, @Colin__Groot , @KeirYong . Vote here: 🗳️
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4 years
NEW: in a large multicenter #tau #PET study (n=2,338), we investigated the impact of several demographic, clinical, genetic and imaging variables on tau PET status, . w/ @biofinder_study @OskarHansson9 @UCSFmac @sylv_villeneuve @RabLab_UCSF and many others!
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4 years
The latest @biofinder_study publication led by @JoanaBPereira1 : "Untangling the association of #amyloid -β and #tau with #synaptic and #axonal loss in #Alzheimer 's disease", ( @Brain1878 ). @NiklasMattsson4 @ErikRubenSmith @OskarHansson9
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On my way back to Amsterdam after an excellent #AAIC24 in Philly.
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5 years
Our latest: " #A β deposition is associated with increases in soluble and phosphorylated #tau that precede a positive Tau #PET in #Alzheimer ’s disease" @ScienceAdvances . @biofinder_study @NiklasMattsson4
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3 years
NEW: Updated prevalence estimates of #amyloid abnormality across the #Alzheimer disease clinical spectrum based on #PET and/or #CSF in 19K+ individuals, . @JAMANeuro Many thanks to all our collaborators!
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3 years
The Atypical Alzheimer's disease PIA proudly presents this webinar on Mar 21 2022 10:00am CT (USA) on the "overlap between the language variant of AD and primary progressive aphasia" with an excellent speaker line-up! @alzassociation @ISTAART @KeirYong @BaaylaB @Rosaleena_M
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4 years
Big day! Today both Tessa Timmers and Emma Wolters (aka “the tau twins”) will defend their #PhD thesis on #tau #PET . @AlzheimerAms @PhilipAlz
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3 years
Check out our latest #tau #PET study across various #MAPT mutations in presymptomatic and symptomatic carriers led by Emma Wolters, . @GreenJournal @AlzheimerAms @AlzheimerEMC @jannepapma @PhilipAlz @HarroSeelaar
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2 months
The BeyeOMARKER study design paper is out! In BeyeOMARKER we will screen 700 individuals with plasma p-tau217 at an eye clinic, and further characterize 150 of them with Amyloid & Tau PET, MRI, retinal imaging and cognitive & cortical vision assessment. Thanks to the great team
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10 months
On my way to the Human Amyloid Imaging conference in Miami, looking forward to great science and catching up with colleagues and friends! #HAI24 @HAIconference
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5 years
Our latest work " #Amyloid and #tau accumulate across distinct spatial #networks and are differentially associated with brain #connectivity " @eLife : . @biofinder_study
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Head-to-Head Comparison of Tau and Amyloid PET Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study Pleased to share our multicenter study led by David Soleimani-Meigooni @UCSFmac . We found that Amyloid-PET and tau-PET
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5 months
APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease @ytquiroz ; I vividly remember you presenting this at our @AtypicalPIA symposium at AAIC. Great to see it published @NEJM , congrats!!! Background: In a person with autosomal dominant Alzheimer’s disease
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6 years
Very honored to receive the European Grand Prix for #Alzheimer Research on behalf of many (inter)national collaborators, my team and mentors! #teamwork @SCOR_SE @Alzh_Fondation
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