Listen up dorks, you just found out Huberman has 6 girlfriends.
You think he’s never heard of peptides?
What's in the sexy toolbox?
For him?
For her???
For them.
𝗣𝗧-𝟭𝟰𝟭.
𝘈𝘯𝘥 𝘭𝘰𝘵𝘴 𝘰𝘧 𝘪𝘵.
What to say about PT-141. 𝗜𝘁 𝘄𝗼𝗿𝗸𝘀.
I’ve been prescribing it
My favorite berberine just got an upgrade
Berberine Phytosome
The phytosome enhances its metabolic activity
Clinical studies have shown that berberine phytosome benefits body composition and can reduce abdominal fat
Berberine phytosome also offers nutritional support for
Gut – Brain Axis
Gut – Joint Axis
Gut – Musculoskeletal Axis
Gut – Thyroid Axis
Gut – Lung Axis
Gut – Skin Axis
Gut – Heart Axis
Gut – Liver Axis
It's probably nothing.
Zinc
Magnesium
Selenium
Copper
MINERAL IMPACT & INTERPLAY
ON GH/IGF
Zinc
[Fundamental Element in GH/IGF-1 Axis]
— Regulates Basic Endocrine Function, ensuring optimal functioning of the GH/IGF-1 axis
— Essential for Production &
A comment I often hear from patients new to testosterone therapy is
I need more testosterone; it's not working!
When does it kick in?
From experience,
The magic number is 14 weeks.
You wake up,
Look in the mirror,
Everything is different.
Here are some things to look
💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙
Methylene blue is the cheapest and most effective brain-fog remover that you're not using
It also does 20 other things that you wouldn't imagine
You should question why you've never heard of it
Here's a few links to devour:
Peptides 💉🧬💉🧬💉
I get asked ALL the time 📲
Research/Chemical Grade 🛁
Pharmaceutical Grade 👩🔬
🤔 What's the difference?
🤷♂️ Is it a big deal?
👨⚕️ I've been prescribing these bad boys for 5+ years and have been using them for 10+
my $0.02👇
If someone is at zero, doesn't know where to start in health, longevity, fitness, or nutrition
but they really want to believe and have a taste
Here are the max ROI levers anyone can do
Vitamins
- FULL dose magnesium and/ or berberine will change your life and make you think
@Denis_protocol
You can offer one compound to an uninitiated friend for his birthday to pique his interest in optimization. Which one do you choose (with realistic constraints) ?
@BowTiedUM
Not alllll of my patients are rich, old, or famous…
But they are mostly all taking
Base:
- GHK-Cu
- BPC
- GH Secretagogue/ GH
- Sex Hormones
Ancillaries:
- MT2
- Methylene Blue
- NAD
- Thymulin
- Glutathione IM
And a handful of vitamins
Happily so, covering every basis
phone notes from 2017
still pretty useful today
first posts for IG
soOoo enthusiastic
bolded the goodies
enjoiii
GLUTAMINE GLUTAMINE GLUTAMINE
GLUTAMINE GLUTAMINE GLUTAMINE
GLUTAMINE GLUTAMINE GLUTAMINE
Let’s talk about glutamine – that pesky guy you may think does nothing…
Diogenes was eating bread and lentils for supper.
He was seen by the philosopher Aristippus,
who lived comfortably by flattering the king.
Said Aristippus
'If you would learn to be subservient to the king you would not have to live on lentils'
Said Diogenes
'Learn to live
Let’s upgrade some definitions…
SHBG isn’t stealing your testosterone
Understand how (& what) SHBG moves
Understand what SHBG means to you
But first… 𝙢𝙚𝙚𝙩 𝙢𝙚𝙜𝙖𝙡𝙞𝙣
— 𝘢 𝘮𝘦𝘮𝘣𝘦𝘳 𝘰𝘧 𝘵𝘩𝘦 𝘭𝘰𝘸 𝘥𝘦𝘯𝘴𝘪𝘵𝘺 𝘭𝘪𝘱𝘰𝘱𝘳𝘰𝘵𝘦𝘪𝘯 𝘳𝘦𝘤𝘦𝘱𝘵𝘰𝘳
There's a few reasons for low magnesium levels
I'm going to share 20 culprits with you
but there's ONE that you CAN'T avoid
It's probably not what you think
Ready?👇
What I find notable when I run in the 300-350 IGF range:
Sleep
— like actual sleep, like the perfect sleep, always. There is no "oops" or bad nights. You sleep. Justl like T regulates our sleep with circadian. GH makes it almost a given.
CON? If you are sensitive or running
@BowTiedOx
My nutrition professor convinced her children that salad was dessert and got them to the point where they would ask for it/ look forward to it at the end of dinner.
Until other families and children inevitably came in with it in the front end.
Without getting into right/
☀️GET YOUR SUNSHINE☀️
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
"Finally, there is evidence that circadian- rhythm disorders might be associated with diabetes, obesity, and cardiovascular disease"
A 🧵 to get you going:
Fitness/ Health
- is it really that easy?
It is when you zoom out
- sleep
- silence
- water
- magnesium
- protein
- good poops
- lift hard 3x per week
- HIIT 2x per week
- walk every day
- don't believe your thoughts
Consistently Simple,
Not Easy
Applied to Everything:
Should probably fix your training first
Should probably fix your testosterone first
Should probably fix your nutrition first
Should probably fix your minerals first
Should probably fix your gut first
Should probably fix your sleep first
Should probably fix your circadian first
@antidoc32
Eat less fats bro, get leaner bro
More carbs bro, more carbs bro
Take more AI bro, hold less water bro
Sell your skin make a leather purse bro
Super Hero Gut Stack
elite
BPC-157 oral
KPV
Larozitide
PepzinGI L-Carnosine
easy daily drivers
Glutamine
IgY Max
Collagen
Broth
These are extremely powerful players that all put in the work. Synergistically more-so.
But don't get it twisted. You don't need them. You don't
Melanocyte
Stimulating
Hormone
🔆[MSH]🔆
- Lifestyle Interventions for MSH
- Hormone Impact on MSH Activity
- Finding & Adapting the dose of MSH
- Too Much MSH: What it looks & feels like
Explore, Discover, Adapt - Now 🧵👇
Alpha-GPC resulted in improved neurological function and post-stroke functional recovery.
1,460 studies examined
15 studies comprising
8,357 subjects were used in the
systematic review
Citicoline did not improve the neurological or functional outcomes in acute stroke patients.
Every time someone flexes Zone 2,
cringe.
HIIT is HIIT
Keep It Simple Stupid
- Michael Scott
Give it everything you got.
Don't ease up.
There's a lion behind you.
He's hungry.
Are you?
100% effort or die.
Adapt or die.
Do you want change on a cellular level?
Give
If you ask someone for help
Show them that you've tried to solve it on your own first
You won't believe how much quicker they will help you - how much more enthusiasm you will receive
We all love to help people who, first of all, tried to help themselves
The best time to do labs,
is when you're feeling amazing.
The best time to do labs,
is when you're feeling like 💩.
The best time to do labs,
is when you want a snapshot of what is going on.
Sometimes we get lost,
This is how you come home.
Live in your sweet spot.
Peptides have been around since the '70s
Bodybuilders have been using them since the '90s
Medicine has been, publicly, using them since '17
It's 2023 & you're worried peptides are disappearing?
The party is just getting started
Pay attention & Chill
@DoctorAnarchist
Word. During 24-36 hour fasts, every 6 hours or as desired, I'll dose into 32oz:
- 5g Glutamine
- 2g Betaine Anhydrous
- 2g Taurine
- 500mg Sodium
- 400mg Potassium [even though it won't really load because no insulin]
- 250-500mg elemental Mg
- lemon juice or CALM powder
You have a stress surplus
& an endogenous BPC deficiency
You have an oxidative environment toxin surplus
& an endogenous GHK deficiency
You have immune-challenge surplus
& an endogenous thymus deficiency
You don't go outside, live under ALAN
& an endogenous α-MSH deficiency
10,000+ steps daily
LISS 2x per week
HIIT 2x per week
LIFT 4x per week
Stress management
Sleep
Water
Protein
Fats
Micronutrients
Vitamins
Hormones
Supplements
Peptides
For 10+ years
👶 Fertility Starter Pack for a Guy
Circadian health w AM sun
Hydration/ Electrolytes
Optimized Minerals
👁️Focus Always
Insulin Sensitivity
Mitochondria
Adrenal health
MAX SLEEP
MIN STRESS
Convince your body you're fertile
↗️Boost
Enclomiphene
pulse HCG
pulse GHRP/ GHRH
I’m a simple man
* Testosterona
* Thymosin Alpha 1
* BPC-157
* GHK-Cu
* Magnesium
Testosterone
- All systems will be challenged, I cannot be in an internal low T environment while whatever is going on. Go into supraphysiological doses that wouldn’t make me need to donate blood
Who Am I,
Guess My Name
In muscles I play quite the part,
Cramps and twitches, that's just the start.
Sleep eludes when I'm not near,
And constipation might appear.
Anxious feelings, headaches too,
Vitamin D feels rather blue.
Crave some chocolate? I'm the reason why,
Bones
TRT = no more LH
HCG = mimics LH
LH = has other benefits outside of keeping your testes sized, voluminous, and somewhat maintaining your fertility
Examples
— keeps machinery lubed up if you decide to reverse off of T; it will be easier
— psychological increase in desire for
Berberine has been shown to improve health markers in patients with non-alcoholic fatty liver disease (NAFLD)
A comprehensive review of 10 randomized clinical trials involving 811 participants was conducted
The focus was on the impact of berberine on various health indicators,
My favorite berberine just got an upgrade
Berberine Phytosome
The phytosome enhances its metabolic activity
Clinical studies have shown that berberine phytosome benefits body composition and can reduce abdominal fat
Berberine phytosome also offers nutritional support for
There are 10,000 things that interact with estrogen.
Within YOUR PROTOCOL you must master your relationship with estrogen before it masters you.
The issue for most people in this space is that they simply have a surplus of estradiol (E2).
Understanding and managing
𝘕𝘰𝘵 𝘴𝘰𝘭𝘥 𝘰𝘯 𝘉𝘦𝘳𝘣𝘦𝘳𝘪𝘯𝘦?
𝘚𝘵𝘪𝘭𝘭 𝘶𝘴𝘪𝘯𝘨 𝘳𝘦𝘨𝘶𝘭𝘢𝘳-𝘴𝘩𝘮𝘦𝘨𝘶𝘭𝘢𝘳 𝘉𝘦𝘳𝘣𝘦𝘳𝘪𝘯𝘦?
The 2023 study assessed the effects of a
𝟮-𝗺𝗼𝗻𝘁𝗵-𝗹𝗼𝗻𝗴 supplementation of
𝗕𝗲𝗿𝗯𝗲𝗿𝗶𝗻𝗲 𝗣𝗵𝘆𝘁𝗼𝘀𝗼𝗺𝗲
𝟱𝟱𝟬𝗺𝗴 𝗯𝗲𝗳𝗼𝗿𝗲 𝗳𝗼𝗼𝗱,
Before reaching for the theanine and magnesium glycinate or the glycine itself...
have you tried hygiene?
- waking up earlier, consistently, every day
- avoiding electronics till 8am
- turning off electronics at 8pm
- creating a restful environment, consistently, every night
/rant
look in the mirror
do you need more size?
do you need to be leaner?
it's that simple.
why are guys in their 40's still stuck
THEY DO NOT GET LEAN
THEY DO NOT STAY LEAN
outside of the FEW everyone is stuck in the same state
and opt for eating like pigs
and chasing
Pro tip
You need an anti-aging guy
Every single one of you needs that person in your corner monitoring your protocol
👀 If you're not living in your sweet spot
👉 You're robbing the whole of society with what you bring to the table: an undistracted you
These guys
Control you estrogen
DON'T CRASH YOUR ESTROGEN
Symptoms include but are not limited to:
- zero drive or zest for life aka a zombie
- disinterest in all matters sex
- apathetic communication
- erectile dysfunction
- painful joints
- constipated
- dry skin
You're basically
Melanocortin Receptors
Five known different melanocortin receptors have been discovered, each with differing specificities for melanocortins:
MC1R
— is associated with pigmentation genetics
MC2R
— is also known as the ACTH receptor
or corticotropin receptor because it is
Listen up dorks, you just found out Huberman has 6 girlfriends.
You think he’s never heard of peptides?
What's in the sexy toolbox?
For him?
For her???
For them.
𝗣𝗧-𝟭𝟰𝟭.
𝘈𝘯𝘥 𝘭𝘰𝘵𝘴 𝘰𝘧 𝘪𝘵.
What to say about PT-141. 𝗜𝘁 𝘄𝗼𝗿𝗸𝘀.
I’ve been prescribing it
You're not you when your hormones are off.
Each combination of hormones is a unique unlock of a 'you'
You can tag these as frequencies.
Some combinations are better than others
- goal dependent one might say.
This is your sweet spot.
Live there.
Your Protocol keeps you
Androgens are everything
You can not reach your potential as a man without thriving hormones:
- High T + DHT
- Low Prolactin
- Balanced estrogen
- Low SHBG
- Androgen receptor sensitivity
These hormones dictate EVERYTHING
- How you perceive yourself
- How others percieve you
-
The best time to do labs,
is when you're feeling amazing.
The best time to do labs,
is when you're feeling like 💩.
The best time to do labs,
is when you want a snapshot of what is going on.
Sometimes we get lost,
This is how you come home.
Live in your sweet spot.
You better have a pair of second eyes,
because more often than not,
yours are telling you lies
the leaner I get
the more "I call myself fat"
the poofier I get
the more "rational my explanations become"
these are signals, not reality
16 years and I still have to
follow a
On the 'need' for TRT
From someone who's managed 1,000+ testosterone patients:
1 - no one should go on T unless they need to
2 - everyone should take steps to optimize T health at all times (maintain, sustain, optimize)
3 - once you have low T, most should exhaust step
There are 10,000 things that interact with estrogen.
Within YOUR PROTOCOL you must master your relationship with estrogen before it masters you.
The issue for most people in this space is that they simply have a surplus of estradiol (E2).
Understanding and managing
Do I need to donate?
You’ll know hemoglobin/ hematocrit is high & when it offsets your quality of life enough:
When you feel blood pressure 🥵 throbs, can’t walk upstairs without being 😮💨, & have anxiety with brain fog for no reason looking like a 🍅 seeing 🫧 tying your 👟
HCG monotherapy is my absolute favorite thing
— and for most people, it's an incredible option
unless you are 'broken'
You can absolutely run HCG monotherapy as a stand-alone HRT
The other options are clomid, but better than clomid would be enclomiphene
Subjectively
Harvest season is upon us!
Time to get to work with my family:
- jams and preserves: quince, strawberry, abricot.
- pickle: cabbage, cucumbers, green tomatoes.
- cook and can tomato sauce and cooked tradional Romanian salads.
- make homemade wine.
Anyone else will be
Hormone & Gut Balance Galore
Simple Solutions I Adore
☀️Sun☀️
🧈Vitamin A🧈
🦪Zinc🦪
🌊Salt water🌊
I think this is a key component
When someone was truly sick, they would take the person to the Black Sea
☀️the sun, the breeze
🌬️healing
💧The water
😪swallow some even
EVERY SINGLE acne case I've ever had has been fixed with the following
Fix your hormones
- Estradiol/ DHT
Fix your gut
- you leaking?
Increase
- water intake
- sun exposure
Decrease
- processed foods
- stress
Bonus
- ocean water
#1
way to avoid “food intolerance” & “food allergy” is ↘️…
Rotate your proteins
Rotate your carbs
Rotate your fats
Rotate everything
New foods lead to waking up enzymes
Emphasize nutrient variety, not just nutrient density
Don’t just eat the same protein, fat, and carb sources for weeks at a time
Switch from beef to bison
Rice to Potatoes
Chicken to Turkey
Switch up where you source your food too
This hedges you against unintended toxin
Test. Don't. Guess.
I don't care how much magnesium you take.
— test don’t guess
I don't care how much testosterone you take.
— test don’t guess
I don't care how much growth hormone you take.
— test don’t guess
10 of the MOST COMMON MAGNESIUM DEFICIENCY SYMPTOMS YOU'LL FEEL
① Headaches
② Low energy
③ Weak bones
④ Eye twitches
⑤ Trouble sleeping
⑥ Chocolate cravings
⑦ Feelings of anxiousness
⑧ Occasional constipation
⑨ Leg cramps and muscle tension
👇You take any of these
Up-to-date
it is established that GHK-Cu peptide is able to:
- Smooth rough skin
- Stimulate wound healing
- Improve overall skin appearance
- Protect skin cells from UV radiation
- Repair protective skin barrier proteins
- Improve skin firmness, elasticity, and clarity
-
In the hush of twilight's gleam,
Take your magnesium, start the dream.
Theanine whispers, soft and fine,
Guiding you to the stars that shine.
Glycine's touch, gentle and true,
Prepares a peaceful night for you.
Turn off this gadget, let it rest,
In slumber's land, you'll be the
You are not sad,
sadness arises.
You are not humble,
humility arises.
You are not depressed,
depression arises.
You are not fatigued,
fatigue arises.
You are not hungry,
hunger happens.
You are not acting,
action happens.
You are not thinking,
thoughts happen.
Are you listening Anon?
It's that simple.
High Carb -> then keep fats low
High Fat -> then keep carbs low
You're fat because all the tasties are a mix of carbs and fats.
Triple OG Nutrition Lore:
are you ready for it?
DO NOT MIX CARBS AND FATS TOGETHER
DO NOT MIX
I rarely have high-carb + high-fat meals
Carbs signal insulin release, helping your cells take in glucose (important)
BUT Insulin also promotes fat storage (converts fatty acids into fat molecules)
I still eat fats. Super necessary. I designate one meal a day to being high fat
[INTRO TO PEPTIDES SERIES]
What is Peptide Therapy
(And How Does it Work?)
🧬 🔬 🧬 🔬 🧬 🔬 🧬 🔬 🧬 🔬
Peptides
— Your Body’s Signaling System
🧬 💉 🧬 💉 🧬 💉 🧬 💉 🧬 💉
A continuation of 👇
Can confirm
YOU are not your body.
YOU is indifferent
Little 'you' goes for a ride.
Testosterone and it's ratio to estrogen as well as relationship with DHT may bring out various frequencies of emotions from within
Little 'you' acts on these fluctuations
High E, Low T
Unpopular Opinion: it's a myth that testosterone makes you angry.
''In fact, people with low testosterone levels are much angrier people" said Dr. Ronald S. Swerdloff, chief of endocrinology at Harbor-U.C.L.A.
It can lift depression defuse aggression."
Can't afford prescription GH?
Don't believe in peptides being enough?
Got yourself some generics,
wondering if it's too good to be true?
𝗧𝗲𝘀𝘁 𝗗𝗼𝗻'𝘁 𝗚𝘂𝗲𝘀𝘀
𝗟𝗶𝘃𝗲 𝗶𝗻 𝗬𝗼𝘂𝗿 𝗦𝘄𝗲𝗲𝘁 𝗦𝗽𝗼𝘁
𝙂𝙚𝙣𝙚𝙧𝙞𝙘 𝙂𝙧𝙤𝙬𝙩𝙝 𝙃𝙤𝙧𝙢𝙤𝙣𝙚 𝙀𝙙𝙞𝙩𝙞𝙤𝙣
y'all sleeping on copper while popping zinc like pez
IDK which phase it is... but eventually, you realize your magnesium is insufficient, and you actually need to work to keep it up...
Just wait until you find out about copper...
5000 FRIENDS!?!
WOW!
THANK YOU <3
Let's do an AMA
For 24 hours - ask whatever you wish, I will do my best to respond to the best of my ability or find you the right person to talk to :)!
How to travel with PT-141
or any peptide for that matter
PT-141 is an inexpensive peptide, mix it for maximum freshness, and use as much as you can... it's your honeymoon, after all...
Grab the room-temperature stable version of PT-141 via SubQ or Intranasal
For other peptides
Summary
𝗟𝗲𝘀𝘀𝗼𝗻 𝗼𝗻 𝗦𝘂𝗻𝗹𝗶𝗴𝗵𝘁 𝗪𝗶𝗻𝗱𝗼𝘄𝘀 𝗮𝗻𝗱 𝗧𝗿𝘂𝗰𝗸 𝗗𝗿𝗶𝘃𝗲𝗿 𝗪𝗿𝗶𝗻𝗸𝗹𝗲𝘀
𝙄𝙣𝙩𝙧𝙤𝙙𝙪𝙘𝙩𝙞𝙤𝙣
*𝗢𝗯𝘀𝗲𝗿𝘃𝗮𝘁𝗶𝗼𝗻: A truck driver has a wrinkled left side of the face, attributed by dermatologists to 20 years of sunlight exposure through
Vitamin A is toxic
Sepsis doesn’t need antibiotics
Leaky gut isn’t real
Neither are auto-immune diseases
Don’t ever change 😘
…having the wrong conversations
You’re scared of needles because of the stories you have behind them
- heroin
- steroids
- shots as a kid
As you rewrite the story, as all the other traumatic stories in your life, to a positive perspective
You can join us in being pin cushions
This injection is nourishing me
Many people have a FEAR of needles 💉
Get into health to avoid being diabetic and on insulin 💉
End up injecting multiple peptides and hormones daily instead 😂
Leaving for later, been too quiet about this one
Testosterone Undecanoate Capsules
Getting closer to mimicing nature in those who are having a hard time harmonizing with nature...
If you can't synch with the☀️& enclom doesn't work, this is your next best shot.
Minus the shot
Got low Testosterone?
Everything in your life up until this point has led you
— to not need T
— not having the resilience to defend your T
So everything moving forward in your life until the end of it should lead you to
— need T
— having the resilience to defend your T
If you want to know what’s going on in the longevity space. Listen to this.
Pay attention.
The amount of truth here is wildly unreachable to most, this is what’s happening on the battle lines to those who are in the game.
The doctor/ clinic writing your script has no idea.
This is a motherfucker of an episode on peptides, regulations, Big Pharma, so forth. Mind blowing stuff
I’m sure
@AbudBakri
and
@Denis_protocol
would love this
My favorite supplements to make amazing GAINS 💪
- L-SLEEPanine
- Acetyl-go-to-gym
- Omega-proper-macros-3
Link in bio to purchase these supplements. Use code GAINS for 100% off.
Imma save you an expensive phone call
Q&A
Will boron & magnesium fix my testosterone?
Will zinc & DIM be enough to manage my gyno?
Maybe
Probably
Most likely 👇🏼
Natural testosterone optimization in forms of giant fat loss, dramatic sleep/circadian changes, or cessation of physical stress (illness)/mental stress, or fixing SEVERE deficiencies
These all could cause a big jump
Otherwise, this kind of jump sounds more like Enclomiphene
Peptides, cheap.
Testing, cheap.
Cutting corners & risking your health,
expensive [see attached DM]
Compounding pharmacies go through quite a bit to get it in your hands...
Research can literally do the same.
Quality research companies doing 3rd party testing can do all
There are no rules but those you impose upon yourself
You are the experiment
Protein?
Water?
Workouts?
Sleep?
Steps?
Overall design?
Some more thoughts on the basics:
Labs may not be enough
Labs provide partial information, reflecting and representing a step or two within the chain of biochemical reactions before a hormone enters a cell
Labs give an idea of the production
Labs give an idea of the amount in the blood
Labs give an idea of the
The best time to do labs is when you’ve been yourself consistently for 2 weeks
2 weeks normal life means whatever-it- means -> for you
Not trying to be clean
Not trying to be perfect
Actual life
Actual sun
Actual travel
Actual sleep
Actual stress
Actual training
Actual