Today the completion of the COVAC Uganda clinical trial was celebrated - the first trial of a self-amplifying RNA vaccine in all of Africa and the first trial of any COVID-19 vaccine candidate in Uganda
Today we had a team meeting where we discussed the successful closure and completion of COVAC Uganda vaccine trial. We reviewed and discussed the progress status and plans of this vaccine technology in the country and world at large.
A mythbusting notice that the
#lableak
#covidorigins
'theory' is absolutely rubbish.
Let me explain as simply as possible, using the most critical data to date. 🧵 1/n
Such an important point on
#covidorigins
: if it were a lab leak, Lineage A would have infected people earlier, and anyone within or closer to the WIV.
It didn't. 1/7
I'm motivated to speak out on
#covidorigins
because it's the clearest example, right after vaccines, where
#scicomm
is losing, with consequences likely to lead to more mistrust in data/research in general. 1/n
@guardian
Instead of supporting my 4-year-old watching one of her favourite movies, this article has shown me the light. From now on, we will watch Schindler's List 🤣
"Misinformation and disinformation proved to be the enemy of good public health implementation not only in the United States but also in many countries throughout the world."
The WIV is in Wuhan, though Wuhan is larger than London. The WIV is over 10 miles away from the Market, no evidence of WIV staff getting ill, and A didn't magically mutate to B by Dec 2019 without leaving intermediates.
That's why a
#lableak
didn't lead to
#SARS2
. [end]
There is no chance
#SARS2
escaped from a lab. Not only was this virus nearly impossible to engineer in 2019, this virus's epidemiology and genomic signatures in early 2020 make it - not just implausible, but impossible - to have research origins. 13/n
The elusive raccoon dog. A mammal susceptible to
#SARS2
, sold live at the Huanan Market by 2019 - could it or other mammals have caused the
#COVID
outbreak in December 2019?
More
#covidorigins
data indicates that yes, such animals remain the most likely culprit. 1/11
I'm almost amazed that this is still a discussion really. There isn't any evidence, compelling or otherwise, of a
#covidorigins
lab leak. It comes down to epi + genomic details of the 2 lineages found in Dec 2019 and early 2020. Nothing about that indicates lab leak, at all.
@WashburneAlex
@jbkinney
I have never been sold on where it comes from. I just don't see any compelling evidence for a lab leak. Sorry. I do, however, see a lot of nutcases that push lab leak and a lot of people who want to sell their books.
Objectively, this report is the most anti-science document I have ever read.
#OriginsofCovid
The veracity on WIV workers getting sick? Check out Feith's bogus reply at 1:12:30 - that allegation has no evidence and was drafted to raise interest
I don't know where to begin about yesterday's Senate report on COVID origins. Besides the vast volume exaggerated or outright fabricated "evidence" & the flagrant display of ineptitude at basic molecular biology, I can't get past this ghastly font choice.
Last weekend, I found a copy of the book “Viral” in the library. Screenshots and references to this book are often included in some nasty replies to some of my threads on
#COVIDOrigins
.
So, what does this book say? 🧵1/23
It's November 2023, what do we know about
#COVIDOrigins
? How strong is the evidence of a zoonotic spillover? Here, I'll sum up all the research and point out what some nefarious players are up to. 1/15
Claims that Proximal Origins was written to silence debate on
#covidorigins
, despite it clearly stating "More scientific data could swing the balance of evidence to favor one hypothesis over another."?
So much for silencing. 🧵1/n
Nearly 1 year on, if only
#covidorigins
#lableak
supporters would read
@MichaelWorobey
et al’s Science 2022 paper, in full.
How does it stand up against its critics? A 🧵. 1/20
A
#lableak
of A would require mutation to B, prior to Dec 2019, yet no evidence of
#COVID19
before then exists. If A and B were equally present in Dec 2019: getting B 12 times in a row has likelihood of 1 in 4,096 (probability = 0.000244).
B spilled over first. 3/n
Important: had a
#lableak
occurred, intermediates between A and B in humans that arose before late Jan 2020 would be "the" 💥 key evidence.
And yet: there is no evidence of early A/B intermediates in people. 5/n
Richard Ebright has never, not once, presented a rational hypothesis for a
#covidorigins
#lableak
. I have threads with dozens of articles supporting zoonotic spillover. He has thrown insults at me and others. He has added nothing to any discussion anywhere. Get well, Richard. 👍
It took but 3 min to exemplify why the new Rubio
#COVIDOrigins
"report" is a watered down Muddy Waters. On pg 63, "experts in the field" cannot find a project's finding.
It took 0.2 sec to find the paper , grant 31770175.
This is not difficult. (1/4)
Based on analysis of these 148 samples from Hubei not analysed in 2022, there are several interesting, similar findings:
➡️ no A/B intermediates
➡️ B arose earlier than A
➡️ mean tMRCA of early Dec 2019
➡️ Rooting of lineages growth stems from Wuhan strains
There's more. 10/n
People became ill in Wuhan in December 2019. Samples were sequenced, and 2
#SARS2
lineages were found (A and B). However, the first 12 were lineage B. 2/n
➡️ presence of D614G mutation
➡️ similar pathogenicity of A and B
D614G found so early (Jan 2020) counters any "pre-adaptation" argument. The virus facilitated better human transmission with this mutation. 11/n
What's next is critical: some sequences were indeed omitted from Pekar 2022 for quality reasons. Claims that these are crucial intermediates is rubbish: none of these 20 are prior to 23 Jan 2020 (most are from Feb 2020). 7/n
Yet A precedes B, doesn't it. The Market 2-spillover theory is simple: A and B arose in animals, and B spilled over first. Any A/B intermediates might remain in animals, though these were gone by 31 Dec 2019, which is why no live Market animals were sampled. 4/n
Despite reviewing mountains of emails and hearing hours of testimony about Fauci and the Proximal Origins
#covidorigins
paper,
@COVIDSelect
missed an actual cover-up.
Thanks to
@mstandaert
for his excellent insights.
A 🧵. This gets wild. 1/n
And similar pathogenicity of A and B is key. If they had different pathogenicity trajectories, one might argue that perhaps A was a quick burner and faded before B came to prominence.
Not the case: A remained and spread very well. 12/n
Lab leakers love emails to attack people because when the
#SARS2
sequence becomes the focus of discussion, well...
Experts know it was impossible to engineer in 2019. Wonderful🧵, from
@wanderer_jasnah
, who knows CoVs. Enjoy this expert insight, and unroll. 👇
#CovidOrigins
okay, here we go. so as i've said numerous times, DEFUSE could not have given us SARSCoV2 b/c:
1) there is no evidence that WIV had a viable progenitor sequence (something very clearly stated in the ODNI report)
2) it was not funded, i.e. the grant proposal went nowhere
An unpublished study analysed 125 samples from a hospital in Wuhan, not uploaded to GISAID and therefore unavailable for inclusion in Pekar 2022 and other studies. A further 42 are from Hubei, 23 of which were not included in Pekar 2022. 9/n
I'm shocked by anyone claiming that
@K_G_Andersen
has not explained the zoonotic spillover theory for
#covidorigins
. He's done it. He does not need to do it again and again.
👉
It’s…. not disinformation to tell him how to communicate information more effectively. If the “other side” has persuasive, easy to understand narratives, you aren’t going to combat that by pointing to scientific articles and congressional testimony.
Last month, this sad reply guy sent me what he called the "best evidence" of a
#covidorigins
lab leak - the June 2023 Times article that:
❌️named an index case as someone who graduated in April 2019
❌️but got their name wrong
❌️was debunked by the ODNI report 2 weeks later
Exciting preprint on
#CovidOrigins
- 1218 bats sampled in Viet Nam show recombinants and similar spikes to
#SARS2
, further supporting 🦇 origin. Phenomal effort and exciting research!
Just one question: 1/3
A sad day in American history. Anyone from this subcommittee is welcome to publish an article on a "cover-up", using US intel (oh, wait). Just remember that it's spelled "genera", not "genre".
Let's see how many scientists step up to help for the next pandemic.🤦
#CovidOrigins
🚨SUBPOENA ALERT🚨
@COVIDSelect
announces its FIRST subpoena for “Proximal Origins” author Kristian Andersen’s private communications with the paper's co-authors & related info on COVID-19 origins.
We are following the breadcrumbs of a COVID cover-up straight to the source!
Astonishingly misleading podcast from
@thetimes
on
#covidorigins
. Claims of uncovering already available info through FOI, unrelated SARS1 work (Mojiang again..) incapable of generating
#SARS2
, "weak" zoonotic evidence, and a hotspot of care for early cases next to the WIV? 1/2
If you don't trust this, you are stuck with a theory that WIV researchers isolated/engineered a new virus, inserted a noncanonical FCS (PRRA) and an RBD, without any knowledge of binding affinities to human ACE2, and passaged this in humanised mice. All in 2018-2019. 5/n
This site is terrific in filling my feed with posts from those that claim facts are missing from Quammen's nytime article on
#covidorigins
and that PO authors are bullies, without giving any examples of either, yet somehow are just fine with this guy.
Not only do virologists strongly dispute this theory, I don't know of ANY wet lab researcher that believes this. It's also exceptionally challenging/costly to do whole genome sequencing, let alone culturing. 6/n
If you don't, you are banking on all of WIV, PO authors, virologists, epidemiologists, and each evolutionary biologist coming to a secret agreement to cover up the LL theory. (Please...just try keeping a secret amongst 5 friends.) 9/n
So much vitriol against scientists on here - but, serious question, does a scientific critique, focusing on the content of the Proximal Origins paper (paper, not authors) even exist?
#covidorigins
Proximal Origins authors have given hours of interviews/explanations and even congressional testimonies, yet are still attacked, professionally and personally.
Strange, because the paper is inconsequential. It really is, because you can't prove a negative. 7/n
What an awful article. Andersen doubted himself as US Intel indicated
#lableak
evidence exists (yet none has been found).
#covidorigins
Disparate: Ladapo lied as he omitted evidence that disproved his desired outcome. That's not insincere, that's fraudulent.
Allegation that Ben Hu, Yu Ping & Yan Zhu fell ill in 2019: this comes from a blog. The US has not yet declassified anything. Ben Hu published a paper 1 month later. And Yu Ping was in Beijing in 2019. This image was taken on 15 Jan 2020, with Ben present.
#CovidOrigins
What utter nonsense. Malone confuses RNA with protein and Ab production.
RNA is detected as a control (for PPIB, NOT spike) for 60d. Vaccine RNA levels decrease in LN from 37d (Fig 7B).
Ab (NOT spike) levels for vaxxed is as high (NOT higher) as patients with severe COVID.
@paimadhu
I have said this elsewhere, but the misinformation is right in front of you - on the poster promoting this video. There are exactly ZERO injectable vaccines for children with 1.5mL doses.
Some
#scicomm
: I have seen the statement “75% of emerging pathogens are zoonotic” several times in media articles during the pandemic, often related to
#covidorigins
.
My Q: where did this stat come from? If true, where does the other 25% originate?
An explainer🧵 1/n
There's a special place in hell for people who engage in scientific misconduct, are also huge assholes about it on Twitter, and then are shamless enough to complain that *they're* the victims somehow.
An excellent summary of why we will be even more unprepared for the next pandemic: experts that stepped up to protect and inform on public health are attacked daily by people who have benefited from those contributions.
Thanks
@K_G_Andersen
.
This
#OriginofCovid
report confirms that no virologist was on the investigative team: the FCS is *not* a con to zoonotic spillover origins.
And what was that about recombination happens only between similar viruses?
📢
The pandemic appeared to originate from a lab accident, based on biosafety issues in the epicenter in Wuhan and factors observed in the nature and early spread of the virus, per a 302-page Senate report obtained by Axios.
If this crew is so happy to publish private messages, they should reveal the source(s) who wrongly identified 3 early career WIV researchers allegedly infected by
#SARS2
in Fall 2019 and accused as starting the pandemic.
And then apologise for that.
#covidorigins
It is NOT any virologist's duty to teach us all about the basics of their field. It's right in front of us; it just requires some reading. 📚
#scicomm
is a 2-way street: looking forward to it running more smoothly. 13/n
Importantly, the first identified furin cleavage site found in this coronavirus family, comes from samples taken in 2016 and 2017.
This further shows how much is unknown about the animal virosphere. Animal sampling and analyses can't keep up with zoonosis.
#covidorigins
1/2
New
#covidorigins
mythbuster: at 25min, George Gao states that maybe they "should have looked at the other"...
Sudworth hears the word "side" and even adds [of the river] i.e. the WIV.
That is NOT what George said. How do I know? Because he told me 1/2
And then? Read more on the wildlife trade in China until the end of 2019. Read more on recombination. Read more on how better nature is than us in creating viruses. Read about the incredible efforts researchers needed to identify animal hosts of other viruses. 12/n
Fascinating articles on
#covidorigins
in
@Virus_Evolution
. Flo Débarre explains her findings on 04 Mar 2023 of the raw sequencing data at the HSM in Jan 2020 👇
1/n
Despite reviewing mountains of emails and hearing hours of testimony about Fauci and the Proximal Origins
#covidorigins
paper,
@COVIDSelect
missed an actual cover-up.
Thanks to
@mstandaert
for his excellent insights.
A 🧵. This gets wild. 1/n
In full support of
#science
, Kristian Andersen and Bob Garry tomorrow. Best of luck to them in receiving 900+ questions about Fauci.
@COVIDSelect
(They could have added that Lineage B spread prior to Lineage A.)
#covidorigins
We don't need another pandemic, and entertaining the lab leak nonsense gets us nowhere. New research shows terrifically high risk of spillover of sarbecoviruses from bats -> livestock/wild mammals -> humans: central and southern China.
#covidorigins
🦠 New Research Alert! Using drivers and transmission pathways to identify SARS-like coronavirus spillover risk hotspots🌍 Where are the hotspots of landscape change, human exposure and host distribution in different scenarios?👇
#Coronavirus
#PandemicPrevention
#OneHealth
1/5
Multiple papers, theses and unpublished works, clarify how the WIV was not researching the progenitor to
#SARS2
. Want a summary of this? Just check out the book Viral, authored and touted by lab leakers.
It says that same: no known
#SARS2
progenitor. 2/n
Last weekend, I found a copy of the book “Viral” in the library. Screenshots and references to this book are often included in some nasty replies to some of my threads on
#COVIDOrigins
.
So, what does this book say? 🧵1/23
This virus had infected one of 161 pangolins smuggled from Southeast Asia into China in 2018–2019, which supports the hypothesis that many mammals were infected by bat viruses in SE Asia by 2019.
#covidorigins
What about unpublished papers? One was rejected in 2018 and summarises parts of genomes from samples on record until 2016. These sequences were released in 2022. None are
#SARS2
progenitors. I'm sharing this Figure again as
@edwardcholmes
has already shared it. 4/n
💥Elucidating explanation of *the* main
#originsofcovid
conundrum: the rooting methodology of
#SARS2
.
Thanks to Flo Débarre and Zach Hansel: an explanation of the flaws for rooting on Lineage A.
#scicomm
1/n
The % of non-bat animal virome that has been sampled is miniscule, yet it's really not challenging to find CGGCGG in natural CoV sequences.
It pops up twice here in a hedgehog sample.
#covidorigins
#SARS2
#covid
#virology
More nonsense calling for virologists to defend themselves, otherwise they caused +18 million deaths. No evidence of RE signature in SARS-COV-2, nor any evidence or plausibility of its glycosylation pattern being lab-engineered. Enough with this nonsense.
The LL theory is fun, it's exciting, but it's also easy. It's also calling many of these individuals liars: particularly when it comes to serological tests for WIV staff, PO authors with their assessment of the implausible engineering of
#SARS2
, and wet market authors. 10/n
A dozen
#COVID19
scientists have filed a formal complaint with Rutgers University alleging that two faculty members violated the university’s policies by posting “provably false” comments that are often defamatory and that could incite harm against them.
These guys blocked me because they could not provide any rational approach to synthesize
#SARS2
by 2019.
In fact, even after 4 yrs, we haven't seen any possible methodology behind a
#lableak
#covidorigins
.
Also, the following papers wouldn't make any sense. 1/10 🧵
Anyway, a
#scicomm
summary; important facts remain
➡️Lineage B cases were the first 12 sequenced
➡️
#SARS2
was not preadapted (D614G came early)
➡️Known cases (B then A) clustered around Market
➡️No A/B intermediates until 2020
➡️No recorded research or cases at WIV [end]
Several wildlife farms were liquidated upon urgent orders, possibly on 31 Dec 2019, leaving no chance to sample suspected hosts. I look forward to learning more about why/how the Market was cleared - more coming soon.
US Intel on
#CovidOrigins
is out. Astoundingly hollow of any
#lableak
evidence, or even indication of evidence.
Any apologies to WIV researchers, virologists, or to those of us that have defended their activities? 🦗🦗🦗
Or skip the book. The WIV isolated only three strains of SARS-related viruses, each of which is published: Nature [2013, 593(7477):535-538], the Journal of Virology [2016, 90(6), 3253-3256] and PLoS Pathogens [2017, 13(11):e1006698]. 3/n
I post on this stuff because I saw (and felt) the attacks on vaccine researchers. The same has happened for virologists. It's ad nauseum attacks on people, devoid of actually reading any papers and looking at data, and it's nonsense. Some examples: 12/15
Relatively little animal sampling has been carried out during the pandemic in Hubei. More from
@mstandaert
on this point here:
, about which Chinese researchers cannot speak: 17/n
To have found 1 (and other positive reads), days after the market was cleared of animals and cleaned, is amazing and indicative of just how much virus was scattered about. 6/7
Very interesting study, showing how mutations arise randomly upon long serial passage of
#SARS2
. What's interesting to me is that it again shows how unstable the FCS is - it's scrambled in all lines, even without immune pressure. 1/3
8⃣ The Market was not a superspreader. Worobey 2022 explicitly explains 2 sets of evidence: the lack of social media check-ins and the presence of Lineage A at the Market.
It's hard to hear lab leakers complain about being silenced b/c of their nonstop conspiratorial screaming over 4 yrs.
Here's Sachs, the leader of The Lancet's
#COVID
Commission, again with a misleading account of all we "know".
#OriginsofCOVID
It's difficult to understand why "we may never know"
#OriginOfCovid
when leaks suggest US has detailed intel on sick Wuhan scientists in fall 2019.
@joshrogin
told
@bariweiss
these scientists worked with bat coronaviruses, lost sense of smell and had lung ground glass opacities.
Despite reviewing mountains of emails and hearing hours of testimony about Fauci and the Proximal Origins
#covidorigins
paper,
@COVIDSelect
missed an actual cover-up.
Thanks to
@mstandaert
for his excellent insights.
A 🧵. This gets wild. 1/n
I have never been funded, directly or indirectly, for any of my
#covidorigins
#scicomm
.
Why do I do it? It interests me.
Who do I do it for? Me.
If anyone is interested and gets to learn anything, or wants a civil discussion, super!
Much of the problem in
#covidorigins
is the perception that there are holes in the PO and Market data that must be defended against the onslaught of nonexistent LL evidence.
Last weekend, I found a copy of the book “Viral” in the library. Screenshots and references to this book are often included in some nasty replies to some of my threads on
#COVIDOrigins
.
So, what does this book say? 🧵1/23
And there is much more to come from animal sampling: let’s be patient. There's certainly better tactics than spurring distrust of researchers in this area. [end]